Nico Van Van Rooijen

Nico Van Van Rooijen's AcademicInfluence.com Rankings

Biology

#4052

World Rank

#6101

Historical Rank

Immunology

#165

World Rank

#173

Historical Rank

biology Degrees

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Biology

Nico Van Van Rooijen's Degrees

PhD Biomedical Sciences University of Amsterdam
Masters Biomedical Sciences University of Amsterdam
Bachelors Biomedical Sciences University of Amsterdam

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Nico Van Van Rooijen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. (1994) (1804)
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. (2013) (1741)
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis (2007) (1706)
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation (2011) (1293)
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. (2007) (1267)
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1 (2004) (1208)
Local proliferation dominates lesional macrophage accumulation in atherosclerosis (2013) (890)
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011) (760)
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis (2012) (739)
Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis (2011) (733)
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. (2010) (729)
Role of macrophage targeting in the antitumor activity of trabectedin. (2013) (682)
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. (2005) (677)
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation1 (2009) (668)
Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. (2013) (664)
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. (2007) (607)
Control of TH17 cells occurs in the Small Intestine (2011) (600)
Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. (2013) (582)
Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice (2005) (532)
Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages (1990) (524)
Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. (1994) (515)
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis (2006) (501)
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. (2010) (488)
Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. (2007) (481)
Macrophage depletion inhibits experimental choroidal neovascularization. (2003) (475)
Major histocompatibility complex class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity (2009) (470)
Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice (1989) (468)
Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues (2008) (436)
Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions (2012) (426)
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. (2012) (415)
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. (2006) (413)
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo (2012) (400)
Kupffer cells promote hepatic steatosis via interleukin‐1β–dependent suppression of peroxisome proliferator‐activated receptor α activity (2010) (391)
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. (2006) (388)
CCR2 promotes hepatic fibrosis in mice (2009) (383)
Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity1 (2009) (382)
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model (2011) (374)
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. (2011) (372)
Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. (1996) (369)
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. (1998) (361)
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. (2009) (360)
Monocyte Chemoattractant Protein-1 Regulation of Blood–Brain Barrier Permeability (2005) (359)
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion (2009) (354)
Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. (1999) (353)
Macrophages in bone fracture healing: Their essential role in endochondral ossification. (2018) (352)
Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin‐induced demyelination (2001) (344)
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. (2011) (333)
Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes (2004) (331)
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. (2004) (327)
TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. (2011) (322)
Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis (2008) (318)
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP (2008) (313)
Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. (2003) (312)
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. (2007) (312)
Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. (1998) (311)
Helminth Infection Protects Mice from Anaphylaxis via IL-10-Producing B Cells1 (2004) (308)
Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination (2008) (304)
Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions (2008) (303)
Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery (2006) (302)
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. (2007) (300)
Importance of Kupffer cells for T-cell-dependent liver injury in mice. (2000) (296)
Liposomes for specific depletion of macrophages from organs and tissues. (2010) (293)
The Role of Macrophages in T Cell–mediated Autoimmune Diabetes in Nonobese Diabetic Mice (1999) (293)
Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. (2007) (286)
Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study. (2006) (277)
The liposome-mediated macrophage 'suicide' technique. (1989) (273)
Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism1 (2007) (272)
Modulation of Dendritic Cell Trafficking to and from the Airways (2006) (271)
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. (2010) (270)
Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection (2011) (269)
Mouse and human neutrophils induce anaphylaxis. (2011) (260)
Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103− Pulmonary Dendritic Cell Populations1 (2008) (258)
Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs (2008) (258)
Liver inflammation abrogates immunological tolerance induced by Kupffer cells (2015) (256)
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. (2002) (254)
Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection (2014) (251)
Suppression of experimental colitis by intestinal mononuclear phagocytes (2006) (248)
Critical Roles of Macrophages in the Formation of Intracranial Aneurysm (2011) (245)
Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. (1994) (240)
Kupffer cell activation is a causal factor for hepatic insulin resistance. (2010) (239)
Neuroprotective function for ramified microglia in hippocampal excitotoxicity (2009) (235)
Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. (2006) (234)
Macrophages prevent hemorrhagic infarct transformation in murine stroke models (2012) (234)
Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice (2013) (229)
CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice (2013) (226)
Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice1 (2001) (224)
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ (1997) (223)
Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice (2010) (221)
Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. (2000) (214)
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. (2006) (214)
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. (2015) (212)
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. (2013) (210)
A Conduit System Distributes Chemokines and Small Blood-borne Molecules through the Splenic White Pulp (2003) (208)
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. (2010) (207)
TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus (2008) (205)
Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia (2013) (204)
Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs (2008) (204)
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. (2010) (204)
An essential role for the Th2-type response in limiting tissue damage during helminth infection (2011) (203)
Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection (1996) (201)
Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity (2009) (201)
Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. (2009) (200)
Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo1 (2008) (200)
Complete protective immunity induced in mice by immunization with the 19-kilodalton carboxyl-terminal fragment of the merozoite surface protein-1 (MSP1[19]) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: correlation of protection with antigen-specific antibody titer, but not with effect (1997) (199)
Kupffer cell depletion by liposome‐delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid (1996) (196)
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. (2016) (193)
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. (2008) (192)
Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. (2007) (191)
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. (2009) (189)
An antigen-specific pathway for CD8 T cells across the blood-brain barrier (2007) (188)
Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats (2010) (185)
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. (2010) (185)
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. (2004) (184)
CD169+ MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES (2010) (177)
ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. (2003) (177)
Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism1 (2001) (175)
IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction (2011) (174)
Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity (2011) (173)
Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. (2000) (169)
Role of host cell traversal by the malaria sporozoite during liver infection (2013) (169)
Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain (2005) (166)
Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma (2014) (165)
Elimination, blocking, and activation of macrophages: three of a kind? (1997) (163)
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. (2011) (163)
Ulcerative colitis exacerbates lipopolysaccharide‐induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease (2010) (163)
Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. (1997) (163)
On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria. (2002) (160)
The Ly-6Chigh Monocyte Subpopulation Transports Listeria monocytogenes into the Brain during Systemic Infection of Mice1 (2004) (157)
The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes. (2006) (156)
Vascular endothelial growth factor‐induced skin carcinogenesis depends on recruitment and alternative activation of macrophages (2012) (156)
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. (2007) (155)
Helminth-Modified Pulmonary Immune Response Protects Mice from Allergen-Induced Airway Hyperresponsiveness1 (2006) (155)
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells. (2012) (154)
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation (2012) (152)
Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone (2014) (152)
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice (2012) (150)
Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. (2010) (150)
The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging. (2013) (149)
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice (2009) (149)
Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors. (2003) (147)
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. (2009) (146)
Inescapable Need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia (2009) (146)
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection (2010) (146)
Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors. (2003) (145)
Systemic Analysis of PPARγ in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity (2012) (145)
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages (2010) (144)
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation (2011) (144)
Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study. (1984) (143)
Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation (2007) (142)
Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. (2013) (142)
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. (2008) (142)
Kupffer cell and interleukin‐12–dependent loss of natural killer T cells in hepatosteatosis (2010) (142)
Macrophages promote polycystic kidney disease progression (2013) (141)
Roles of Macrophages and Neutrophils in the Early Host Response to Bacillus anthracis Spores in a Mouse Model of Infection (2006) (140)
Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells (2009) (138)
Role of macrophages during Theiler's virus infection (1997) (138)
Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus. (2008) (137)
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. (2015) (137)
Hepatocyte entry leads to degradation of autoreactive CD8 T cells (2011) (137)
Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells (2012) (136)
Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. (1995) (135)
Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response (2008) (135)
Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes. (2006) (134)
Macrophages Induce the Inflammatory Response in the Pulmonary Arthus Reaction through Gαi2 Activation That Controls C5aR and Fc Receptor Cooperation1 (2005) (134)
Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus (2010) (134)
Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages1 (2008) (134)
Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver (1996) (133)
Meningeal and Perivascular Macrophages of the Central Nervous System Play a Protective Role During Bacterial Meningitis (2001) (133)
Improved Innate Immunity of Endotoxin-Tolerant Mice Increases Resistance to Salmonella enterica Serovar Typhimurium Infection despite Attenuated Cytokine Response (2001) (130)
Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen (1993) (129)
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. (2005) (129)
Depletion of Bone Marrow–derived Macrophages Perturbs the Innate Immune Response to Surgery and Reduces Postoperative Memory Dysfunction (2013) (129)
Macrophages act as effectors of tissue damage in acute renal allograft rejection (2003) (129)
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. (2005) (127)
Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling. (1997) (127)
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence (2018) (127)
"In vivo" depletion of macrophages by liposome-mediated "suicide". (2003) (127)
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. (2011) (127)
C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis1 (2004) (125)
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. (2013) (125)
The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. (2009) (125)
Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses (2012) (125)
Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury. (2003) (124)
A Novel Type I IFN-Producing Cell Subset in Murine Lupus1 (2008) (123)
Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, doses of bacterial endotoxin in rats. (1991) (123)
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection. (2006) (123)
Macrophages direct tumour histology and clinical outcome in a colon cancer model (2005) (122)
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts (2012) (121)
Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection (2014) (121)
Complementary Adhesion Molecules Promote Neutrophil- Kupffer Cell Interaction and the Elimination of Bacteria Taken Up by the Liver1 (2002) (121)
Flow-Dependent Remodeling of Small Arteries in Mice Deficient for Tissue-Type Transglutaminase: Possible Compensation by Macrophage-Derived Factor XIII (2006) (121)
Transient suppression of macrophage functions by liposome-encapsulated drugs. (1997) (119)
Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice (2011) (119)
Resident macrophages influence stem cell activity in the mammary gland (2009) (118)
Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. (2009) (118)
Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver (2007) (116)
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high‐fat diet (2011) (116)
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. (2012) (114)
Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites (2010) (113)
Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein (2008) (113)
Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. (1995) (112)
Stat3 Activation in Acute Lung Injury1 (2004) (111)
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma (2008) (110)
Requirement for testicular macrophages in Leydig cell proliferation and differentiation during prepubertal development in rats. (1994) (110)
Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype (2011) (110)
A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells. (2003) (110)
A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. (2013) (109)
Liver-stage development of Plasmodium falciparum, in a humanized mouse model. (2006) (108)
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. (2010) (107)
Kupffer Cells Hasten Resolution of Liver Immunopathology in Mouse Models of Viral Hepatitis (2011) (107)
Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. (1995) (107)
Prostaglandin E₂ signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. (2011) (106)
An early complement‐dependent and TLR‐4–independent phase in the pathogenesis of ethanol‐induced liver injury in mice (2009) (104)
Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30. (2007) (104)
Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice (2006) (103)
CLEC‐2 signaling via Syk in myeloid cells can regulate inflammatory responses (2011) (102)
Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function (2012) (101)
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities. (2007) (101)
Depletion and reconstitution of macrophages in mice. (2012) (101)
Macrophage Depletion Abates Porphyromonas gingivalis–Induced Alveolar Bone Resorption in Mice (2014) (101)
T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts1 (2003) (101)
The trans-Sialidase from Trypanosoma cruzi Induces Thrombocytopenia during Acute Chagas' Disease by Reducing the Platelet Sialic Acid Contents (2005) (101)
Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis (1999) (101)
CCR2 Mediates Homeostatic and Inflammatory Release of Gr1high Monocytes from the Bone Marrow, but Is Dispensable for Bladder Infiltration in Bacterial Urinary Tract Infection1 (2008) (100)
Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo (2013) (99)
IgA EGFR antibodies mediate tumour killing in vivo (2013) (99)
Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model. (2009) (99)
IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis. (2010) (99)
Human FcγRIIA induces anaphylactic and allergic reactions. (2012) (98)
An Innate Response to Allogeneic Nonself Mediated by Monocytes1 (2009) (98)
A new method for removal of mononuclear phagocytes from heterogeneous cell populations in vitro, using the liposome-mediated macrophage 'suicide' technique. (1990) (97)
MHC class I–specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice (2011) (97)
The location of splenic NKT cells favours their rapid activation by blood-borne antigen (2012) (95)
Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. (2000) (95)
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. (2009) (94)
Epilysin (MMP-28) Restrains Early Macrophage Recruitment in Pseudomonas aeruginosa Pneumonia1 (2009) (94)
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing (2005) (94)
Role of Macrophages in Early Host Resistance to Respiratory Acinetobacter baumannii Infection (2012) (93)
The role of macrophages in Acanthamoeba keratitis. (1996) (93)
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation (2013) (92)
Oncogenic Properties of Apoptotic Tumor Cells in Aggressive B Cell Lymphoma (2015) (91)
Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection. (2000) (90)
Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis (1998) (90)
Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone. (2008) (90)
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells (2007) (90)
Cutting Edge: The Murine High-Affinity IgG Receptor FcγRIV Is Sufficient for Autoantibody-Induced Arthritis (2011) (90)
Monocytes control natural killer cell differentiation to effector phenotypes. (2011) (89)
Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. (2009) (89)
CLODRONATE LIPOSOMES: PERSPECTIVES IN RESEARCH AND THERAPEUTICS (2002) (89)
The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores. (2004) (89)
Early Vascular Permeability in Murine Experimental Peritonitis Is Comediated by Resident Peritoneal Macrophages and Mast Cells: Crucial Involvement of Macrophage-Derived Cysteinyl-Leukotrienes (2002) (89)
Pertussis Toxin Targets Airway Macrophages To Promote Bordetella pertussis Infection of the Respiratory Tract (2007) (89)
Macrophage‐derived osteopontin induces reactive astrocyte polarization and promotes re‐establishment of the blood brain barrier after ischemic stroke (2015) (89)
Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model. (2003) (87)
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis, myeloablation and in JAK2V617F-induced polycythemia vera (2012) (86)
Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X (2010) (86)
Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis (2008) (86)
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon‐I‐dependent manner in mice (2010) (86)
Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells. (1998) (85)
Macrophages Restrict Pseudomonas aeruginosa Growth, Regulate Polymorphonuclear Neutrophil Influx, and Balance Pro- and Anti-Inflammatory Cytokines in BALB/c Mice1 (2003) (85)
Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection1 (2009) (85)
Macrophage-Mediated but Gamma Interferon-Independent Innate Immune Responses Control the Primary Wave of Plasmodium yoelii Parasitemia (2007) (85)
Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections (2000) (84)
A1 adenosine receptors in microglia control glioblastoma-host interaction. (2006) (84)
Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. (1998) (82)
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. (2011) (82)
Liposome-mediated macrophage depletion: an experimental approach to study the role of testicular macrophages in the rat. (1993) (82)
Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression. (2016) (82)
Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats. (1997) (81)
Intrabursal Injection of Clodronate Liposomes Causes Macrophage Depletion and Inhibits Ovulation in the Mouse Ovary1 (2000) (81)
Pig islet xenograft rejection is markedly delayed in macrophage‐depleted mice: a study in streptozotocin diabetic animals (2000) (80)
Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model. (2000) (80)
Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. (2008) (80)
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. (2008) (80)
NK Cells, but Not NKT Cells, Are Involved in Pseudomonas aeruginosa Exotoxin A-Induced Hepatotoxicity in Mice1 (2004) (80)
Analysis of Eosinophil Turnover In Vivo Reveals Their Active Recruitment to and Prolonged Survival in the Peritoneal Cavity1 (2007) (79)
Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40 (2008) (79)
In Aged Mice, Outgrowth of Intraocular Melanoma Depends on Proangiogenic M2-Type Macrophages (2010) (79)
Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice (2008) (78)
Macrophages Subvert Adaptive Immunity to Urinary Tract Infection (2015) (78)
Macrophages play a dual role during pulmonary tuberculosis in mice. (2005) (78)
Murine Kupffer Cells Are Protective in Total Hepatic Ischemia/Reperfusion Injury with Bowel Congestion through IL-10 (2010) (77)
Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. (2011) (77)
Tumor Necrosis Factor (TNF) Protects Resistant C57BL/6 Mice against Herpes Simplex Virus-Induced Encephalitis Independently of Signaling via TNF Receptor 1 or 2 (2006) (77)
Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate (2010) (75)
Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection (1997) (75)
Prevention of corneal allograft rejection in rats treated with subconjunctival injections of liposomes containing dichloromethylene diphosphonate. (1994) (75)
Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. (1996) (74)
Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80(+)VCAM1(+)CD169(+)ER-HR3(+)Ly6G(+) erythroid island macrophages in the mouse. (2014) (74)
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. (2013) (74)
Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB. (1999) (74)
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa. (2011) (74)
Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury. (2009) (73)
Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer (2008) (72)
In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. (1993) (72)
The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen. (1989) (72)
Macrophage derived Wnt signalling opposes Notch signalling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse (2012) (72)
Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control (2009) (72)
Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration. (2007) (72)
Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury. (2011) (72)
Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver. (2009) (72)
Macrophage-depletion influences the course of murine HSV-1 keratitis. (2000) (71)
Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. (1999) (71)
Influence of carriers on the development and localization of anti‐2,4,6‐trinitrophenyl (TNP) antibody‐forming cells in the murine spleen: II. Suppressed antibody response to TNP‐Ficoll after elimination of marginal zone cells (1986) (71)
The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. (2011) (70)
Is there a single differentiation pathway for all antibody-forming cells in the spleen? (1986) (70)
Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins. (1994) (69)
Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats (2003) (69)
Effects of macrophage depletion at different times after treatment with ethylene dimethane sulfonate (EDS) on the regeneration of Leydig cells in the adult rat. (1994) (69)
CD8− Dendritic Cells and Macrophages Cross-Present Poly(D,L-lactate-co-glycolate) Acid Microsphere-Encapsulated Antigen In Vivo (2011) (69)
Gr1+ Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague (2009) (68)
c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis (2012) (68)
Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice. (2007) (68)
Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune-Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression (2009) (68)
Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid (2016) (68)
Modulation of Macrophage Activation State Protects Tissue from Necrosis during Critical Limb Ischemia in Thrombospondin-1-Deficient Mice (2008) (68)
Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. (2010) (68)
Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection (2010) (67)
Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk. (2005) (67)
SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis. (2010) (67)
Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection (2017) (67)
An Innate Immune System Cell Is a Major Determinant of Species-Related Susceptibility Differences to Fungal Pneumonia1 (2005) (67)
Macrophage depletion alters vein graft intimal hyperplasia. (1999) (65)
Mobilization and Margination of Bone Marrow Gr-1high Monocytes during Subclinical Endotoxemia Predisposes the Lungs toward Acute Injury1 (2009) (65)
IgG subclasses determine pathways of anaphylaxis in mice (2017) (65)
Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. (1995) (65)
Kupffer cell–monocyte communication is essential for initiating murine liver progenitor cell–mediated liver regeneration (2015) (64)
Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. (2000) (64)
Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. (2004) (64)
Cell-Type-Specific Type I Interferon Antagonism Influences Organ Tropism of Murine Coronavirus (2011) (64)
Iron‐ and inflammation‐induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo (2005) (63)
Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility. (2010) (63)
Microglia and a Functional Type I IFN Pathway Are Required To Counter HSV-1–Driven Brain Lateral Ventricle Enlargement and Encephalitis (2013) (63)
MCP-1 Expression in CNS-1 Astrocytoma Cells: Implications for Macrophage Infiltration into Tumors In vivo (2004) (63)
Critical Role of Macrophages and Their Activation via MyD88-NFκB Signaling in Lung Innate Immunity to Mycoplasma pneumoniae (2010) (62)
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. (2009) (62)
Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria (2015) (62)
Urokinase-Type Plasminogen Activator Plays Essential Roles in Macrophage Chemotaxis and Skeletal Muscle Regeneration1 (2008) (62)
Macrophages play a key role in angiogenesis and adipogenesis in a mouse tissue engineering model. (2013) (62)
Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles. (2012) (61)
Technical Advance: Autofluorescence as a tool for myeloid cell analysis (2010) (61)
MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries (2008) (61)
The Role of Host and Microbial Factors in the Pathogenesis of Pneumococcal Bacteraemia Arising from a Single Bacterial Cell Bottleneck (2014) (60)
TNF-induced target cell killing by CTL activated through cross-presentation. (2012) (60)
IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. (1998) (60)
PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury (2007) (60)
Human Malaria in Immunocompromised Mice: New In Vivo Model for Chemotherapy Studies (2001) (59)
Circulation of human hematopoietic cells in severe combined immunodeficient mice after Cl2MDP-liposome-mediated macrophage depletion. (1995) (59)
Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulfonate in rats. (1994) (59)
Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency (2012) (59)
CXCL10/CXCR3 signaling in glia cells differentially affects NMDA‐induced cell death in CA and DG neurons of the mouse hippocampus (2009) (59)
CD11b+, Ly6G+ Cells Produce Type I Interferon and Exhibit Tissue Protective Properties Following Peripheral Virus Infection (2011) (59)
Liposome mediated affection of monocytes. (1992) (58)
The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens (1998) (58)
Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross‐sensitization effects (2001) (58)
Depletion of Blood-Borne Macrophages Does Not Reduce Demyelination in Mice Infected with a Neurotropic Coronavirus (1999) (57)
Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. (2004) (57)
Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. (1999) (57)
IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals (2013) (56)
Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye. (2012) (56)
Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats. (2005) (56)
The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. (2012) (56)
Differential in vivo effects of a superantigen and an antibody targeted to the same T cell receptor. Activation-induced cell death vs passive macrophage-dependent deletion. (1994) (56)
Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats. (2000) (56)
Humoral Immune Responses Against Particulate Bacterial Antigens are Dependent on Marginal Metallophilic Macrophages in the Spleen (1996) (56)
Macrophage Depletion in Hypertensive Rats Accelerates Development of Cardiomyopathy (2009) (55)
Small Artery Remodeling and Erythrocyte Deformability in L-NAME-Induced Hypertension: Role of Transglutaminases (2007) (55)
Tissue Tropism and Target Cells of NSs-Deleted Rift Valley Fever Virus in Live Immunodeficient Mice (2011) (54)
Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages. (1985) (54)
Interferon‐gamma–mediated tissue factor expression contributes to T‐cell‐mediated hepatitis through induction of hypercoagulation in mice (2013) (54)
Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation. (1997) (53)
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. (2011) (52)
Distinctive roles of neutrophils and monocytes in anti-thy-1 nephritis. (2000) (52)
Cytological basis of immune functions of the spleen. Immunocytochemical characterization of lymphoid and non-lymphoid cells involved in the 'in situ' immune response. (1989) (52)
CEACAM1+ myeloid cells control angiogenesis in inflammation. (2009) (52)
A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis (2000) (52)
Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model. (2002) (52)
Roles of Macrophages in Flow-Induced Outward Vascular Remodeling (2009) (51)
Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. (2002) (51)
Bone Marrow B Cell Apoptosis During In Vivo Influenza Virus Infection Requires TNF-α and Lymphotoxin-α1 (2002) (50)
Liposome mediated depletion of macrophages: an approach for fundamental studies. (1994) (50)
Marginal zone of the spleen and the development and localization of specific antibody-forming cells against thymus-dependent and thymus-independent type-2 antigens. (1986) (50)
Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection (2017) (50)
Multiple Helminth Infection of the Skin Causes Lymphocyte Hypo-Responsiveness Mediated by Th2 Conditioning of Dermal Myeloid Cells (2011) (50)
Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. (2011) (50)
Elimination of spleen and of lymph node macrophages and its difference in the effect on the immune response to particulate antigens. (1990) (50)
Liver endothelial cells participate in T‐cell‐dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo (1995) (50)
Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus. (2012) (50)
Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection. (2008) (49)
Bone Fracture Exacerbates Murine Ischemic Cerebral Injury (2013) (49)
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein (2014) (49)
Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats (1993) (49)
Specific Depletion of Ly6Chi Inflammatory Monocytes Prevents Immunopathology in Experimental Cerebral Malaria (2015) (48)
Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome (2008) (48)
Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures (2012) (48)
The influence of macrophage depletion on ligament healing (2011) (47)
Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma (2014) (47)
Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events (2013) (47)
Activator protein-1 activation in acute lung injury. (2002) (47)
Macrophage depletion alters the blood–nerve barrier without affecting Schwann cell function after neural injury (2007) (47)
Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. (2013) (46)
Type 1 IFN Deficiency in the Absence of Normal Splenic Architecture during Lymphocytic Choriomeningitis Virus Infection1 (2006) (46)
Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons (2014) (46)
CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation. (2012) (46)
Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. (2008) (46)
In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects. (1996) (45)
CSF-1–Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses (2011) (45)
Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon. (2005) (45)
T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells. (1997) (44)
Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response (2014) (44)
Neutrophils Sequestered in the Liver Suppress the Proinflammatory Response of Kupffer Cells to Systemic Bacterial Infection1 (2009) (44)
T‐zone localized monocyte‐derived dendritic cells promote Th1 priming to Salmonella (2011) (44)
CD68 acts as a major gateway for malaria sporozoite liver infection (2015) (44)
Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: a quid pro quo in pancreatic cancer. (2013) (44)
Cytokine‐independent repression of rodent Ntcp in obstructive cholestasis (2005) (44)
CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF-β (2013) (43)
A protective role for interleukin 18 in interferon γ-mediated innate immunity to Cryptosporidium parvum that is independent of natural killer cells. (2012) (43)
Heart Grafts Tolerized Through Third‐Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression (2013) (42)
The role of Kupffer cells in the differentiation process of hepatic natural killer cells (1995) (42)
Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex. (2005) (42)
Biodistribution of clodronate and liposomes used in the liposome mediated macrophage 'suicide' approach. (1996) (42)
Splenic B Cells from Hymenolepis diminuta–Infected Mice Ameliorate Colitis Independent of T Cells and via Cooperation with Macrophages (2015) (42)
A Protease-Dependent Mechanism for Initiating T-Dependent B Cell Responses to Large Particulate Antigens (2010) (42)
Macrophage‐dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat (2002) (42)
Mechanisms of anaphylaxis in human low‐affinity IgG receptor locus knock‐in mice (2016) (42)
Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury (2013) (42)
Intratumoral But Not Systemic Delivery of CpG Oligodeoxynucleotide Augments the Efficacy of Anti-CD20 Monoclonal Antibody Therapy Against B Cell Lymphoma (2009) (41)
A Novel Model of Demyelinating Encephalomyelitis Induced by Monocytes and Dendritic Cells1 (2006) (41)
Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria (2003) (41)
Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis (2007) (41)
MUCOSAL IMMUNOADJUVANT ACTIVITY OF LIPOSOMES: ROLE OF ALVEOLAR MACROPHAGES (1996) (41)
Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice (2009) (40)
Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice. (2008) (40)
TNP-enzyme conjugates for the detection of anti-TNP antibody producing cells in vivo. (1984) (40)
Kupffer Cell-Expressed Membrane-Bound TNF Mediates Melphalan Hepatotoxicity via Activation of Both TNF Receptors1 (2005) (40)
The effect of elimination of macrophages on the tissue distribution of liposomes containing [3H]methotrexate. (1984) (40)
Febrile-Range Temperature Modifies Early Systemic Tumor Necrosis Factor Alpha Expression in Mice Challenged with Bacterial Endotoxin (1999) (39)
Lethal Hepatitis After Gene Transfer of IL-4 in the Liver Is Independent of Immune Responses and Dependent on Apoptosis of Hepatocytes: A Rodent Model of IL-4-Induced Hepatitis1 (2001) (39)
Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation (2014) (39)
Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats. (1993) (39)
Highly Biased Type 1 Immune Responses in Mice Deficient in LFA-1 in Listeria monocytogenes Infection Are Caused by Elevated IL-12 Production by Granulocytes 1 (2003) (38)
Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice (2006) (38)
Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event. (2008) (38)
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses (2012) (38)
INNATE INFLAMMATORY CELLS ARE NOT RESPONSIBLE FOR EARLY DEATH OF DONOR MYOBLASTS AFTER MYOBLAST TRANSFER THERAPY (2004) (37)
Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia. (2019) (37)
Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow. (2013) (37)
Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59. (1997) (37)
Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction. (2004) (37)
Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 (2014) (37)
Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. (2002) (37)
Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. (2005) (37)
Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. (1995) (36)
Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5. (2012) (36)
Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosa. (2014) (36)
Intravenous Immunoglobulin Promotes Antitumor Responses by Modulating Macrophage Polarization (2014) (36)
Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia (2018) (36)
Macrophages are vital in spontaneous intraocular tumor eradication. (2006) (36)
Elimination of resident macrophages from the livers and spleens of immune mice impairs acquired resistance against a secondary Listeria monocytogenes infection (1997) (36)
Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity. (2011) (36)
Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model (2013) (35)
Cutting Edge: Contribution of NK Cells to the Homing of Thymic CD4+NKT Cells to the Liver1 (2000) (35)
Analysis of innate defences against Plasmodium falciparum in immunodeficient mice (2010) (35)
Dietary n-3 fatty acids increase spleen size and postendotoxin circulating TNF in mice; role of macrophages, macrophage precursors, and colony-stimulating factor-1. (1996) (35)
Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta1 in healing rat vein grafts. (2004) (35)
Macrophage subpopulations in the mouse spleen renewed by local proliferation. (1994) (35)
Liposomes in immunology: multilamellar phosphatidylcholine liposomes as a simple, biodegradable and harmless adjuvant without any immunogenic activity of its own. (1980) (34)
Conjunctival macrophage‐mediated influence of the local and systemic immune response after corneal herpes simplex virus‐1 infection (2002) (34)
The role of macrophages in the pathogenesis of HSV-1 induced chorioretinitis in BALB/c mice. (1994) (34)
On the influence of neutrophils in corneas with necrotizing HSV-1 keratitis following amniotic membrane transplantation. (2007) (34)
Induction of CD8+ T Lymphocytes by Salmonella typhimurium Is Independent of Salmonella Pathogenicity Island 1-Mediated Host Cell Death1 (2002) (33)
Increased Resistance of LFA-1-Deficient Mice to Lipopolysaccharide-Induced Shock/Liver Injury in the Presence of TNF-α and IL-12 Is Mediated by IL-10: A Novel Role for LFA-1 in the Regulation of the Proinflammatory and Anti-Inflammatory Cytokine Balance1 (2003) (33)
Immunomodulation with liposomes: the immune response elicited by liposomes with entrapped dichloromethylene-diphosphonate and surface-associated antigen or hapten. (1987) (33)
Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection. (1996) (33)
Importance of Bacterial Replication and Alveolar Macrophage-Independent Clearance Mechanisms during Early Lung Infection with Streptococcus pneumoniae (2015) (33)
JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions. (2007) (32)
Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis. (1998) (32)
Exercise Promotes Collateral Artery Growth Mediated by Monocytic Nitric Oxide (2015) (32)
Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. (2000) (32)
MACROPHAGES PLAY A ROLE IN THE EARLY PHASE OF CORNEAL ALLOGRAFT REJECTION IN RATS (2004) (31)
Role of macrophages in early protective immune responses induced by two vaccines against foot and mouth disease. (2011) (31)
Dexamethasone promotes tolerance in vivo by enriching CD11cloCD40lo tolerogenic macrophages (2013) (31)
The development of specific antibody‐containing cells and the localization of extracellular antibody in the follicles of the spleen of rabbits after administration of free or liposome‐associated albumin antigen (1983) (31)
Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo. (2010) (31)
Marginal zone of the murine spleen in autotransplants: functional and histological observations in the response against a thymus-independent type 2 antigen. (1989) (31)
NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model. (2011) (31)
SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. (2009) (31)
The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates. (2006) (31)
Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats. (2015) (30)
Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat (2012) (30)
Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells. (2007) (30)
Intra-intestinal priming leads to antigen-specific IgA memory cells in peripheral lymphoid organs. (1985) (30)
A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol-linked proteins. (2004) (30)
Use of liposomes as biodegradable and harmless adjuvants. (1983) (30)
Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN (2010) (30)
Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade. (2004) (30)
Pulmonary immunity to Listeria is enhanced by elimination of alveolar macrophages. (1999) (30)
Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. (2012) (30)
Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere. (2008) (29)
The human chorionic gonadotrophin-induced inflammation-like response is enhanced in macrophage-depleted rat testes. (1993) (29)
Double-enzyme conjugates, producing an intermediate color, for simultaneous and direct detection of three different intracellular immunoglobulin determinants with only two enzymes. (1986) (29)
No attenuation of ischemic and reperfusion injury in Kupffer cell-depleted, cold-preserved rat livers. (1997) (29)
Unique Requirements for Reactivation of Virus-Specific Memory B Lymphocytes (2010) (29)
Myofiber damage precedes macrophage infiltration after in vivo injury in dysferlin-deficient A/J mouse skeletal muscle. (2015) (29)
Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia. (2007) (29)
Role of Macrophages in the Altered Epithelial Function during a Type 2 Immune Response Induced by Enteric Nematode Infection (2014) (29)
Liposomes as antigen carriers and adjuvants in vivo. (1992) (29)
Key role of macrophages in hypotensive side effects of immunoglobulin preparations. Studies in an animal model. (1989) (29)
Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages. (2001) (29)
Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice. (2007) (29)
Host Genetics and Chlamydia Disease: Prediction and Validation of Disease Severity Mechanisms (2012) (28)
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. (2013) (28)
Block of Death-Receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and Is a Determinant of Virulence in Immunodeficient Hosts (2012) (28)
CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. (2008) (28)
Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment. (1999) (28)
Lymphocyte migration in the spleen: the effect of macrophage elimination. (1989) (28)
The development of specific antibody‐containing cells in the spleen of rabbits during the secondary immune response against free or liposome‐associated albumin antigen (1984) (28)
A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcγ Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice (2012) (28)
Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts (2003) (28)
Double immunocytochemical staining in the study of antibody-producing cells in vivo. Combined detection of antigen specificity (anti-TNP) and (sub)class of intracellular antibodies. (1985) (28)
Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2low Bimhigh phenotype, poor CTL function and cell death. (2012) (27)
Secondary Intracerebral Hemorrhage Due to Early Initiation of Oral Anticoagulation After Ischemic Stroke: An Experimental Study in Mice (2012) (27)
Mechanism of follicular trapping: localization of immune complexes and cell remnants after elimination and repopulation of different spleen cell populations. (1990) (27)
Vesicular Stomatitis Virus Genomic RNA Persists In Vivo in the Absence of Viral Replication (2009) (27)
Macrophages in host defense mechanisms. (1996) (27)
Effects of clodronate and pamidronate on splenic and hepatic phagocytic cells of mice. (1991) (26)
Inadequate anti-polysaccharide antibody responses in the chicken. (1998) (26)
The in situ immune response of the rat after intraperitoneal depletion of macrophages by liposome-encapsulated dichloromethylene diphosphonate. (1991) (26)
The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig‐to‐C6‐deficient rat heart transplantation model (1999) (26)
Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium. (2007) (26)
Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen, II. Cellular, but not humoral, systemic immune responses against rabies virus immune‐stimulating complexes are macrophage dependent (1998) (26)
Immune complexes on follicular dendritic cells as a target for cytolytic cells in AIDS. (1989) (25)
Different responses of macrophages in retinal ganglion cell survival after acute ocular hypertension in rats with different autoimmune backgrounds. (2007) (25)
Selective role for tumor necrosis factor-α, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. (2011) (25)
Role of the testis in the response of the pituitary-testicular axis to nitric oxide-related agents. (1997) (25)
A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. (2012) (25)
5-Azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia (2010) (25)
Delayed graft rejection in pre-vascularised corneas after subconjunctival injection of clodronate liposomes. (2000) (25)
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer. (2012) (24)
Antigen processing and presentation in vivo: the microenvironment as a crucial factor. (1990) (24)
Antigen trapping in the spleen of the turtle, Chrysemys scripta elegans. (1983) (24)
Macrophage Depletion Attenuates Chronic Cyclosporine A Nephrotoxicity (2010) (24)
Systemic Macrophage Depletion Inhibits Helicobacter bilis-Induced Proinflammatory Cytokine-Mediated Typhlocolitis and Impairs Bacterial Colonization Dynamics in a BALB/c Rag2 −/− Mouse Model of Inflammatory Bowel Disease (2012) (24)
Liposome-mediated elimination of macrophages. (1992) (24)
Surfactant Protein A Suppresses Lipopolysaccharide-Induced IL-10 Production by Murine Macrophages1 (2001) (24)
Autoradiography and immunohistoperoxidase techniques applied to the same tissue section. (1976) (23)
Generation of a dual-functioning antitumor immune response in the peritoneal cavity. (2013) (23)
Direct intrafollicular differentiation of memory B cells into plasma cells. (1990) (23)
Double immunocytochemical staining in the study of antibody-producing cells in vivo. Detection of specific antibody-producing cells in the spleen and simultaneous determination whether or not they produce immunoglobulin G antibodies. (1984) (23)
Islet transplantation in the discordant tilapia-to-mouse model: a novel application of alginate microencapsulation in the study of xenograft rejection (2003) (23)
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract. (2015) (23)
Primary sity immune response in popliteal lymph nodes and spleen of mice after subcutaneous immunization with thymus‐dependent or thymus‐independent (type 1 and 2) antigens (1989) (23)
Binding of Candida albicans yeast cells to mouse popliteal lymph node tissue is mediated by macrophages (1993) (23)
In vivo distribution of particulate antigens and liposomes in murine spleen. A possible role in the humoral immune response. (1993) (23)
Effects of neutrophil, natural killer cell, and macrophage depletion on murine Clostridium piliforme infection (1997) (23)
Double immunocytochemical evidence for a clonal development of specific antibody‐containing cells in the rabbit spleen (1984) (22)
Mouse adenovirus type 1 infection of macrophages. (2009) (22)
Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. (2002) (22)
Splenic Phagocytes Promote Responses to Nucleosomes in (NZB × NZW) F1 Mice1 (2008) (22)
Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity. (2012) (22)
Enhanced T-cell-independent Antitumor Effect of Cyclophosphamide Combined With Anti-CD40 mAb and CpG in Mice (2011) (22)
Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease. (2016) (21)
Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen caused by opioidergic transmission. (1998) (21)
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis (2013) (21)
Mechanism of follicular trapping: similarities and differences in trapping of antibody-complexed antigens and carbon particles in the follicles of the spleen. (1983) (21)
Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses. (2014) (21)
Role of testicular macrophages in the response of Leydig cells to gonadotrophins in young hypophysectomized rats. (1995) (21)
Critical Role of Effector Macrophages in Mediating CD4-Dependent Alloimmune Injury of Transplanted Liver Parenchymal Cells1 (2008) (21)
Regulatory T Cells Suppress Natural Killer Cells during Plasmid DNA Vaccination in Mice, Blunting the CD8+ T Cell Immune Response by the Cytokine TGFβ (2010) (21)
Hyperglycemia and PPAR&ggr; Antagonistically Influence Macrophage Polarization and Infarct Healing After Ischemic Stroke (2015) (21)
A trinitrophenyl(TNP)-poly-L-lysine-horseradish peroxidase conjugate for the detection of anti-TNP antibodies in vivo. (1985) (21)
The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1. (2008) (21)
The role of macrophages in LPS-induced lethality and tissue injury. (1988) (20)
Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages – studies in a rat model (2001) (20)
Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. (2013) (20)
The in situ immune response in popliteal lymph nodes of mice after macrophage depletion. Differential effects of macrophages on thymus-dependent and thymus-independent immune responses. (1990) (20)
Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47 (2011) (20)
Hepatocyte cytoskeleton during ischemia and reperfusion--influence of ANP-mediated p38 MAPK activation. (2005) (20)
Fate of endothelialized modular constructs implanted in an omental pouch in nude rats. (2009) (20)
TLR7/9-mediated monocytosis and maturation of Gr-1(hi) inflammatory monocytes towards Gr-1(lo) resting monocytes implicated in murine lupus. (2011) (19)
Cross-Activating Invariant NKT Cells and Kupffer Cells Suppress Cholestatic Liver Injury in a Mouse Model of Biliary Obstruction (2013) (19)
Double immunocytochemical staining in the study of antibody-producing cells in vivo. Simultaneous detection of anti-hapten and anti-carrier antibody-producing cells in lymphoid tissue. (1984) (19)
Response to Leydig cell apoptosis in the absence of testicular macrophages. (1995) (18)
A Novel Animal Model of Borrelia recurrentis Louse-Borne Relapsing Fever Borreliosis Using Immunodeficient Mice (2009) (18)
Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium (2007) (18)
The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages. (2010) (18)
Pituitary-testicular axis in rats lacking testicular macrophages. (1995) (18)
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions. (2009) (18)
Liposomes for targeting of antigens and drugs: Immunoadjuvant activity and liposome-mediated depletion of macrophages (2008) (18)
Selective Depletion of Alveolar Macrophages in Polymicrobial Sepsis Increases Lung Injury, Bacterial Load and Mortality but Does Not Affect Cytokine Release (2008) (18)
Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice. (2013) (18)
Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. (2011) (17)
Delayed graft rejection in pre-vascularised corneas after subconjunctival injection of clodronate liposomes (2000) (17)
Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds (2008) (17)
Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses. (2005) (17)
Mechanism of follicular antigen trapping. Migration of antigen-antibody complexes from marginal zone towards follicle centres. (1973) (17)
Role of phagocytic macrophages in induction of contact hypersensitivity and tolerance by hapten applied to normal and ultraviolet B-irradiated skin. (1994) (16)
Macrophage depletion following liposomal‐encapsulated clodronate (LIP‐CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice (2003) (16)
Are bacterial endotoxins involved in autoimmunity by CD5+ (Ly-1+) B cells? (1989) (16)
Macrophages as accessory cells in the in vivo humoral immune response: from processing of particulate antigens to regulation by suppression. (1992) (16)
Transient depletion of specific immune cell populations to improve adenovirus‐mediated transgene expression in the liver (2015) (16)
Phagocytosis and lymphocyte migration: evidence that lymphocyte trapping in the spleen following carbon injection is not due to direct lymphocyte-macrophage adherence. (1980) (16)
Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy. (2007) (16)
Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. (2011) (16)
Role of synovial macrophages in experimental arthritis. (1992) (16)
Depletion of Systemic Macrophages by Liposome‐Encapsulated Clodronate Attenuates Increases in Brain Quinolinic Acid During CNS‐Localized and Systemic Immune Activation (1999) (16)
The architecture of the spleen of the red‐eared slider, Chrysemys scripta elegans (reptilia, testudines) (1982) (16)
Effects of chronic injection of sphingomyelin-containing liposomes on lymphoid and non-lymphoid cells in the spleen. Transient suppression of marginal zone macrophages. (1988) (15)
Elimination of various subpopulations of macrophages and the development of multiple-organ dysfunction syndrome in mice. (1997) (15)
Double immunocytochemical staining for in vivo detection of epitope specificity and isotype of antibody-forming cells against synthetic peptides homologous to human immunodeficiency virus-1. (1990) (15)
Liposomes in immunology: evidence that their adjuvant effect results from surface exposition of the antigens. (1980) (15)
Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function. (2009) (15)
Clodronate treatment significantly depletes macrophages in chickens. (2014) (15)
Preparation and characteristics of dichloromethylene diphosphonate-containing liposomes. (1986) (15)
Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN-dependent anti-GBM nephritis in mice. (1997) (14)
Effects of macrophage depletion on peritoneal inflammation in swiss mice, edible frogs and goldfish. (2004) (14)
A systemic macrophage response is required to contain a peripheral poxvirus infection (2017) (14)
Brucella abortus causes an accelerated repopulation of the spleen and liver of mice by macrophages after their liposome-mediated depletion. (1995) (14)
Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon (2010) (14)
Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse. (1996) (14)
Cytotoxic T lymphocytes and antibodies after orthotropic penetrating keratoplasty in rats treated with dichloromethylene diphosphonate encapsulated liposomes. (1998) (14)
Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice. (2014) (14)
Inflammatory Ly-6Chi monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients (2012) (13)
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. (2011) (13)
Antigen processing of vesicular stomatitis virus in situ. Interdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4(+) and CD8(+) T cells. (2000) (13)
Chronic inflammation induces the expression of dendritic cell markers not related to functional antigen presentation on peritoneal exudate macrophages. (1991) (13)
Combination of Cyclophosphamide, Rituximab, and Intratumoral CpG Oligodeoxynucleotide Successfully Eradicates Established B cell Lymphoma (2012) (13)
Role of macrophages and natural killer cells in the rejection of pig islet xenografts in mice. (2000) (13)
Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury. (2014) (13)
Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. (1999) (13)
Macrophages are involved in hexachlorobenzene-induced adverse immune effects. (2005) (12)
Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis. (2012) (12)
Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. (2003) (12)
Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage "suicide" technique. (1992) (12)
The secondary immune response against liposome associated antigens. (1981) (12)
Differential requirements for CTL generation by novel immunostimulants: APC tropism, use of the TAP-independent processing pathway, and dependency on CD80/CD86 costimulation. (2003) (12)
Circulating tumor necrosis factor-alpha does not mediate endotoxin-induced hypothermia in rats. (1995) (12)
Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation (2013) (11)
Antigens in the spleen. The non-specificity of the follicles in the process of antigen trapping and the role of antibody. (1972) (11)
A comparative study on the effectiveness of various procedures for attachment of two proteins (L-asparaginase and horse radish peroxidase) to the surface of liposomes. (1983) (11)
Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents (2008) (11)
Evidence that macrophages in the marginal zone have no role in the migration of lymphocytes into the periarteriolar lymphocyte sheaths (PALS). (1985) (11)
Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats. (2018) (11)
Double immunocytochemical staining in the study of antibody-producing cells in vivo. Simultaneous detection of cells producing monospecific antibodies and cells producing cross-reacting antibodies in the spleen of rabbits after injection of two related antigens. (1984) (11)
Mechanism of follicular antigen trapping. Evidence for a two cell mechanism using double isotope autoradiography. (1974) (11)
Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis (2010) (11)
Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum (2017) (11)
The immune response in the rat to Streptococcus pneumoniae type 3 and type 4 capsular polysaccharide. Detection by double immunocytochemical staining of antibody-containing cells in situ and ELISA. (1991) (11)
Enhanced triggering of mucosal immune responses by reducing splenic phagocytic functions (1993) (11)
Effects of Ischemia on Lung Macrophages (2011) (10)
Macrophage-Produced IL-12p70 Mediates Hemorrhage-Induced Damage in a Complement-Dependent Manner (2011) (10)
Enhancement of Bordetella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract. (2011) (10)
Mechanism of follicular trapping: double immunocytochemical evidence for a contribution of locally produced antibodies in follicular trapping of immune complexes. (1985) (10)
Effects of liposome-encapsulated drugs on macrophages: comparative activity of the diamidine 4',6-diamidino-2-phenylindole and the phenanthridinium salts ethidium bromide and propidium iodide. (1998) (10)
Macrophages and nitric oxide are involved in primary nonfunction of islet xenografts. (1995) (10)
In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. (2011) (10)
The role of natural antibodies and ABO (H) blood groups in transplantation of human lymphoid cells into mice (1993) (10)
Peroxidase immunocytochemistry for the detection of specific anti-hapten (penicilloyl) antibody producing cells in the spleen, after injection of a hapten-carrier conjugate. (1984) (10)
Liposomes as an in vivo tool to study and manipulate macrophage function. (1992) (10)
The “in situ” immune response in lymph nodes: A review (1987) (9)
Liposome mediated modulation of macrophage functions. (1994) (9)
Combination therapy with hepatocyte growth factor and oseltamivir confers enhanced protection against influenza viral pneumonia. (2014) (9)
Bone marrow transplant conditioning intensified with liposomal clodronate to eliminate residual host antigen presenting cells fails to ameliorate GVHD and increases PERI-BMT mortality. (2001) (9)
Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC). (2008) (9)
Negligible role for NK cells and macrophages in delayed xenograft rejection (2000) (9)
Macrophage-depletion influences the course of murine HSV-1 keratitis (2000) (9)
Lethality in an anti‐angiogenic tumor gene therapy model upon constitutive but not inducible expression of the soluble vascular endothelial growth factor receptor 1 (2008) (8)
Rapid recovery of platelet count following administration of liposome‐encapsulated clodronate in a mouse model of immune thrombocytopenia (2002) (8)
Tumor transition zone: a putative new morphological and functional hallmark of tumor aggressiveness. (2005) (8)
The Role of CD1d-Restricted NKT Cells in the Clearance of Pseudomonas aeruginosa from the Lung Is Dependent on the Host Genetic Background (2015) (8)
The humoral immune response in the spleen. (1991) (8)
T cells and macrophages in Trypanosoma brucei-related glomerulopathy (1994) (7)
Mouse spleen dendritic cells. Phagocytic activity and expression of macrophage markers. (1997) (7)
F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo (2016) (7)
Interference with Dendritic Cell Populations Limits Early Antigen Presentation in Chronic γ-Herpesvirus-68 Infection (2010) (7)
Casein kinase‐II inhibition promotes retinal ganglion cell survival and axonal regeneration (2018) (7)
Monoclonal antibody mediated targeting of enzymes. A comparative study using the mouse spleen as a model system. (1992) (7)
Complement enhances the elimination of soluble aggregates of IgG by rat liver endothelial cells in vivo (1993) (7)
The role of macrophages in the hypothalamic-pituitary-adrenal activation in response to endotoxin (LPS). (1992) (6)
The vascular pathways in the white pulp of the rabbit spleen. (1972) (6)
Liposomes as immunological adjuvants. (1982) (6)
Suppression of T cells results in long‐term survival of mouse heart xenografts in C6‐deficient rats (2001) (6)
TRAIL-Dependent Resolution of Pulmonary Fibrosis (2018) (6)
Liposomes in immunology: the immune response against antigen-containing liposomes. (1977) (6)
Local immunologic factors determine the occurrence of primary nonfunction of islet xenografts. (1994) (6)
Relative roles of T cells and macrophages in cytokine-mediated functional transformation of cultured splenic dendritic cells. (1995) (6)
Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (C12MBP)suppresses nitric oxide production and reduces genetic resistance to Marek's disease (2003) (6)
Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy. (2007) (5)
Binding of labelled antigens and immune complexes to macrophages and dendritic cells in cryostat sections of normal mouse spleen. (1978) (5)
A new model for limbal transplantation using E-GFP for follow-up of transplant survival. (2006) (5)
Role of liver endothelial and Kupffer cells in clearance of human Clq in rats (1993) (5)
The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells. (2005) (5)
Role of phagocytic synovial lining cells in experimental arthritis. (1993) (5)
Immunoglobulin M antiplatelet autoantibodies from mice immunized with rat platelets induce thrombocytopenia and platelet function impairment (2010) (5)
Development of specific antibody‐forming cells in various lymphoid organs of rabbit after intravenous antigen administration (1987) (5)
Immunoadjuvant activities of liposomes: two different macrophage-mediated mechanisms. (1993) (5)
Macrophage derived signalling regulates negatively the megakaryocyte compartment. (2004) (4)
Cancer-induced Expansion and Activation of CD11b+Gr-1+ Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions. (2009) (4)
Combined autoradiography and reticulin staining by silver impregnation or T-B lymphocyte staining by immunoperoxidase techniques in the study of migration of labeled lymphocytes. (1982) (4)
Liposomes as carrier for antibiotics: a comparative study on the immune response against liposome-encapsulated penicillin and other penicillin preparations. (1986) (4)
Fluorochrome staining of multilamellar liposomes. (1978) (4)
Inhibition of Recall Responses through Complementary Therapies Targeting CD8+ T-Cell- and Alloantibody-Dependent Allocytotoxicity in Sensitized Transplant Recipients (2013) (4)
Blood pressure control: a facelift for macrophages? (2010) (4)
Microglia/Macrophages and CD4+CD25+ T Cells Enhance the Ability of Injury-Activated Lymphocytes to Reduce Traumatic Optic Neuropathy In Vitro (2021) (4)
Liposomes as carrier and immunoadjuvant of vaccine antigens. (1990) (4)
Manipulation of Macrophage Activities Using Liposomes (2000) (3)
Characterization of cell populations, reappearing in the mouse spleen after elimination by liposome encapsulated dichloromethylene diphosphonate: reappearance of marginal zone lymphocytes is independent of marginal zone macrophages. (1988) (3)
Association of an albumin antigen with phosphatidylcholine liposomes alters the nature of immunoglobulins produced during the immune response against the antigen. (1983) (3)
Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis (2020) (3)
Six methods for separate detection of two different antigens in the same tissue section. (1980) (3)
In vivo activity of rituximab-CpG oligodeoxynucleotide conjugate against rituximab-resistant human CD20+ B-cell lymphoma. (2009) (2)
Human Malaria in Immunocompromised Mice (2000) (2)
The separate detection of two radioactively labelled compounds in tissue sections or cell smears on a lightmicroscopic level: a review on double radionuclide autoradiography. (1976) (2)
Effect of plasma exchange in combination with deoxyspergualin on the survival of guinea‐pig hearts in macrophage‐depleted C6‐deficient rats (2003) (2)
Use of dichloromethylene bisphosphonate (Cl2MBP) to deplete macrophage function in the chicken. (2003) (2)
Follicular dendritic cell-B cell interactions in virus disease. Common localization but different cell damage caused by antibody immobilized virus? (1992) (2)
Nonspecific nature of antigen trapping in lymphoid follicles. (1973) (2)
Detection of specific anti-hapten antibody-producing hybridoma cells in tissue sections of spleen and liver by hapten-enzyme conjugates using an immunoenzyme approach. (1986) (2)
High and low cytosolic Ca2+ induced macrophage death? Hypothesis. (1991) (2)
The development of specific antibody producing cells in the spleen of rabbits during the primary and secondary immune response. (1985) (2)
Immune complexes in the spleen. The difference between competitive inhibition of immune complex trapping in spleen follicles and inhibition by paratyphoid vaccine. (1975) (2)
The immune response to staphylococcal antigens in mice depleted of macrophages by Cl2MDP-liposomes. (1997) (2)
Endotoxin enhanced adjuvant effect of liposomes, particularly when antigen and endotoxin are incorporated within the same liposome. (1980) (2)
A method for the separate detection of two labelled antigens in lymphoid tissues, using two different radioisotopes and a double autoradiographic stripping technique. (1973) (2)
Attempts to study the localization of liposomes and liposome entrapped antigen in the spleen. (1979) (2)
Platelet-activating Factor Contributes to Bacillus anthracis Lethal Toxin-associated Damage* (2014) (2)
The role of the FDC-retained immune complex network and its dynamics in the activity of germinal centres. (1993) (1)
Specific antibody forming cells in lymphoid follicles of spleen: an aspect of the late immune response. (1988) (1)
Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures (2012) (1)
Liver Fetuin-A at Initiation of Insulin Resistance (2022) (1)
Neuroprotective function for ramified microglia in hippocampal excitotoxicity (2012) (1)
Applicabilities of some modifications of a double isotope autoradiographic method for separate detection of 3H and 131I or 32P in tissue sections or cell smears. (1977) (1)
Labelling of lymphocytes with various radiosotopes for in vivo tracer studies; a review. (1977) (1)
Liposomes in immunology: further evidence for the adjuvant activity of liposomes. (1978) (1)
The role of antigens, antibodies and immune complexes in the functional activity of germinal centres. (1991) (1)
Antigen processing of vesicular stomatitis virus in situ. Interdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4+ and CD8+ T cells (2000) (1)
Glioma Induce and Exploit Microglial Membrane Type 1 Metalloprotease Expression for Tumor Expansion: 974 (2009) (1)
The limitations of immunoenzyme approaches to distinguish between 'specific' and 'non-specific' antibody-forming cells, with particular respect to immunocytochemical studies on the in situ immune response. (1987) (1)
The application of autoradiography and other immunohistochemical techniques to the same tissue section or cell smear. (1981) (0)
The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins (2012) (0)
Overcoming brain immune privilege with Flt3L and TK treatment in a recurrent rat glioma model (2008) (0)
Evidence for a clonal development of specific antibody forming cells in the spleen. (1985) (0)
Development of antibody-forming cells in follicles of lymph nodes of mice after continuous antigenic stimulation. (1991) (0)
A method for the separate detection of tritium and iodine radioisotopes in the same cell smear using a double autoradiographic stripping technique. (1973) (0)
Immune complexes in the spleen. Replacement of immune complexes trapped in spleen follicles by new immune complexes from the circulation. (1975) (0)
BONE MARROW TRANSPLANT CONDITIONING INTENSIFIED WITH LIPOSOMAL CLODRONATE TO ELIMINATE RESIDUAL HOST ANTIGEN PRESENTING CELLS FAILS TO AMELIORATE GVHD AND INCREASES PERI-BMT MORTALITY1 (2001) (0)
In vivo effects of lipopolysaccharide on lymphoid and non-lymphoid cells in the mouse spleen. Suppressive and adjuvant effects of LPS on the development of specific antibody forming cells in situ. (1987) (0)
The interplay of macrophages and dendritic cells with WNV-specific T cells during single-cycle flavivirus immunization. (P6332) (2013) (0)
Immune complexes in the spleen: three concentric follicular areas of immune complex trapping, their interrelationships and possible function. (1977) (0)
Kupffer cell function is important to overcome septic complications after partial liver resection (1998) (0)
ELIMINATION OF VARIOUS SUBPOPULATIONS OF MACROPHAGES AND THE DEVELOPMENT OF THE MULTIPLE ORGAN DYSFUNCTION SYNDROME IN MICE: 144 (1997) (0)
Immunomodulation Using Peripheral Macrophage Depletion and cAMP Elevation Promotes Neuroprotection and Improves Locomotor Recovery after Contusive Spinal Cord Injury: 932 (2009) (0)
Liposomes in immunology: impairment of the adjuvant effect of liposomes by incorporation of the adjuvant lysolecithin and the role of macrophages. (1979) (0)
The problematic detection of 51Cr-labelled lymphocytes by autoradiography. (1978) (0)
Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen caused by opioidergic transmission. (1998) (0)
Antigens in the spleen: localization of labelled antigen in the spleen of normal rabbits and rabbits preimmunized with a non related antigen. (1973) (0)
The effectiveness of 3H-uridine and 3H-leucine for labeling of T and B cells of rats and mice. (1983) (0)
Subcapsular sinus macrophages prevent lethal vesicular stomatitis virus (VSV) infection (43.11) (2009) (0)
The location of splenic NKT cells favours their rapid activation by blood‐borne antigen (2013) (0)
New Approaches to Pathogenesis and Management of Hypertension (2009) (0)
Antigen trapping and lymphoid cell retention in spleen follicles: a comparative study on the localization in mouse spleen of 131I-HGG-anti-HGG and 3H-labelled spleen cells from syngeneic donor mice preinjected with HGG-anti-HGG. (1974) (0)
Extracellular and intracellular action of clodronate in osteolytic bone diseases? A hypothesis. (1993) (0)
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation (2012) (0)

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What Schools Are Affiliated With Nico Van Van Rooijen?

Nico Van Van Rooijen is affiliated with the following schools:

Tohoku University
Chiba University
Vrije Universiteit Amsterdam
University of Sydney
Montana State University
Eastern Virginia Medical School