Nicolas H. Thomä
#183,322
Most Influential Person Now
German scientist
Nicolas H. Thomä's AcademicInfluence.com Rankings
Nicolas H. Thomächemistry Degrees
Chemistry
#5761
World Rank
#6985
Historical Rank
Organic Chemistry
#1047
World Rank
#1180
Historical Rank
Nicolas H. Thomäbiology Degrees
Biology
#15529
World Rank
#19531
Historical Rank
Molecular Biology
#2733
World Rank
#2775
Historical Rank
Biochemistry
#2754
World Rank
#2942
Historical Rank
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Chemistry Biology
Why Is Nicolas H. Thomä Influential?
(Suggest an Edit or Addition)According to Wikipedia, Nicolas H. Thomä is a German researcher, full professor at the EPFL School of Life Sciences and Director of the Paternot Chair for Cancer Research in Lausanne, Switzerland. He is a biochemist and structural biologist and a leading researcher in the fields of ubiquitin ligase biology and DNA repair.
Nicolas H. Thomä's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Histone methylation by PRC2 is inhibited by active chromatin marks. (2011) (635)
- Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide (2014) (618)
- Determinants and dynamics of genome accessibility (2011) (453)
- Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex (2008) (390)
- The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation (2011) (358)
- Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase (2016) (319)
- Regulation of Heterochromatic Silencing and Histone H 3 Lysine-9 Methylation by RNAi (2002) (272)
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN (2018) (229)
- The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. (2011) (223)
- Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54 (2005) (191)
- Crystal structure of the human COP9 signalosome (2014) (189)
- Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7. (2014) (152)
- Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome (2016) (151)
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (139)
- Rational discovery of molecular glue degraders via scalable chemical profiling (2020) (125)
- Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. (2003) (120)
- Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains* (2003) (119)
- Structural mechanism of cGAS inhibition by the nucleosome (2020) (112)
- Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes (2018) (110)
- Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions (2013) (92)
- Mechanisms of OCT4-SOX2 motif readout on nucleosomes (2020) (90)
- An N‐terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks (2012) (81)
- Crystal structures of human cardiac β-myosin II S2-Δ provide insight into the functional role of the S2 subfragment (2006) (77)
- Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins. (2001) (76)
- Thoma, N.H. et al. Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54. Nat. Struct. Mol. Biol. 12, 350-356 (2005) (71)
- Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1 (2014) (67)
- DNA damage detection in nucleosomes involves DNA register shifting (2019) (62)
- Detecting UV‐lesions in the genome: The modular CRL4 ubiquitin ligase does it best! (2011) (59)
- Regulatory control of DNA end resection by Sae2 phosphorylation (2018) (56)
- Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein (2015) (48)
- Double Prenylation by RabGGTase Can Proceed without Dissociation of the Mono-prenylated Intermediate* 210 (2001) (48)
- Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II. (2001) (47)
- Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. (2006) (44)
- Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends (2017) (43)
- Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins. (2001) (43)
- Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome (2015) (39)
- PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. (2020) (37)
- Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase. (2000) (36)
- Haven't got a glue: Protein surface variation for the design of molecular glue degraders. (2021) (35)
- Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II. (2000) (35)
- Semi‐synthetic Rab proteins as tools for studying intermolecular interactions (2000) (34)
- Phosphoisoprenoids Modulate Association of Rab Geranylgeranyltransferase with REP-1* (2001) (34)
- Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase. (1998) (34)
- Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation (2019) (32)
- BANP opens chromatin and activates CpG-island-regulated genes (2021) (29)
- SPLINTS: small-molecule protein ligand interface stabilizers. (2016) (29)
- Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane (2019) (26)
- Reading the chromatinized genome (2021) (23)
- Tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-CoA mutase. (1996) (20)
- Minishelterins separate telomere length regulation and end protection in fission yeast (2015) (20)
- Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. (2002) (20)
- Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks (2018) (18)
- In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex. (2002) (15)
- Quality control of protein complex assembly by the ubiquitin-proteasome system. (2022) (13)
- Structural insights into Fe–S protein biogenesis by the CIA targeting complex (2020) (10)
- Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE. (2020) (10)
- Mechanistic and structural studies on methylmalonyl-CoA mutase. (1998) (8)
- Targeted protein degradation: You can glue it too! (2017) (7)
- What to do if there is no signal: using competition experiments to determine binding parameters (2003) (7)
- RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1 (2021) (7)
- Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes (2018) (6)
- Live analysis and reconstruction of single-particle cryo-electron microscopy data with CryoFLARE (2019) (6)
- Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase. (2001) (5)
- The CRL4DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state (2021) (5)
- Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase III α and RMI 1 (5)
- RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1. (2022) (4)
- Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid (2003) (3)
- Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting (2019) (1)
- Recognition of the CCT5 di‐Glu degron by CRL4DCAF12 is dependent on TRiC assembly (2023) (1)
- Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report (2022) (1)
- Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron. (2022) (1)
- Mechanism of substrate binding and product release by geranylgeranyl-transferase type II (2000) (1)
- Global control of DNA replication timing by the budding yeast telomere protein Rif1 (2013) (1)
- Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling (2021) (1)
- Crystal structure of the Rap1 C-terminal domain (Rap1-RCT) in complex with the Rap1 binding module of Rif1 (Rif1-RBM) (2013) (0)
- RIF 1 acts in DNA repair through phosphopeptide recognition of 53 BP 1 (0)
- Structural mechanism of cGAS inhibition by the nucleosome (2020) (0)
- STRUCTURE OF A BRCA2-DSS1 COMPLEX (2002) (0)
- A deep dive into degrader-induced protein-protein interfaces. (2023) (0)
- The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective (2016) (0)
- STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX (2002) (0)
- Crystal Structure of the Cop9 Signalosome (2014) (0)
- Structure of the hsDDB1-drDDB2 complex (2009) (0)
- Cryo-EM structure of NCP_THF2(-3) (2019) (0)
- Crystal structure of Nurf55 in complex with Su(z)12 (2011) (0)
- Abstract PL02-03: The zinc-finger degrome (2019) (0)
- Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae (2013) (0)
- Readout of histone methylation by Trim24 locally restricts chromatin opening by p53 (2022) (0)
- Volpe Methylation by RNAi Regulation of Heterochromatic Silencing and Histone H 3 Lysine-9 (2010) (0)
- Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB (2019) (0)
- Crystal structure of the human nucleosome containing 6-4PP (outside) (2015) (0)
- Crystal structure of the human topoisomerase III alpha-RMI1 complex with bound calcium ion (2014) (0)
- OCT4-SOX2-bound nucleosome - SHL-6 (2020) (0)
- FANally…A Structure Emerges of the Fanconi Anemia Core Complex. (2020) (0)
- Cryo-EM structure of NCP_THF2(-1)-UV-DDB (2019) (0)
- Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting (2019) (0)
- Crystal structure of Nurf55 in complex with histone H3 (2011) (0)
- Taking the Brakes Off Targeted Protein Degradation. (2020) (0)
- Kobe University Repository : Kernel タイトル Tit le DNA damage detect ion in nucleosomes involves DNA register shift (2020) (0)
- STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX (2011) (0)
- UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability (2022) (0)
- Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A (2019) (0)
- Crystal structure of Saccharomyces cerevisiae RIF2 (2013) (0)
- Cryo-EM structure of NCP-6-4PP (2019) (0)
- Structure of hsDDB1-drDDB2 bound to a 14 bp 6-4 photoproduct containing DNA-duplex (2009) (0)
- Crystal structure of the COP9 signalosome, a P1 crystal form (2015) (0)
- Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings (2023) (0)
- Structure of the CAND1-CUL4B-RBX1 complex (2011) (0)
- Cryo-EM structure of the BRISC complex bound to SHMT2 (2019) (0)
- DNA damage detection in nucleosomes involves DNA register shifting (2019) (0)
- Global control of DNA replication timing by the budding yeast telomere protein Rif1 (2013) (0)
- Regulatory control of DNA end resection by Sae2 phosphorylation (2018) (0)
- Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane (2019) (0)
- X-Ray Diffraction data from Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae in complex with DNA, source of 5NW5 structure (2017) (0)
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (0)
- Cryo-EM structure of NCP_THF2(-3)-UV-DDB (2019) (0)
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