Nigel W Bunnett
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Nigel W Bunnett's Degrees
- PhD Neuroscience University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
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(Suggest an Edit or Addition)Nigel W Bunnett's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. (2004) (1326)
- Protease-activated receptors: contribution to physiology and disease. (2004) (1042)
- Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism (2000) (932)
- β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2 (2000) (841)
- 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 (2007) (703)
- Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. (2007) (674)
- Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. (1998) (641)
- T cell gelatinases mediate basement membrane transmigration in vitro. (1995) (545)
- Role for protease activity in visceral pain in irritable bowel syndrome. (2007) (540)
- Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. (2006) (533)
- Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. (1997) (522)
- Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. (1996) (460)
- Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway (2001) (457)
- Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes (1996) (447)
- Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. (2014) (423)
- The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. (2000) (413)
- Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia (2004) (400)
- Protease-activated receptors in inflammation, neuronal signaling and pain. (2001) (378)
- Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. (2002) (374)
- Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice (2007) (363)
- Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. (2008) (347)
- Endosomes: A legitimate platform for the signaling train (2009) (346)
- Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. (1997) (325)
- Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. (1996) (324)
- Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. (1997) (308)
- Mast Cell Tryptase Controls Paracellular Permeability of the Intestine (2005) (307)
- Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution (2008) (295)
- The TGR5 receptor mediates bile acid-induced itch and analgesia. (2013) (290)
- Mechanisms of Desensitization and Resensitization of Proteinase-activated Receptor-2* (1996) (269)
- Proteinase-activated Receptors, Targets for Kallikrein Signaling* (2006) (240)
- The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. (2013) (237)
- Protease‐activated receptor 2 sensitizes TRPV1 by protein kinase Cɛ‐ and A‐dependent mechanisms in rats and mice (2006) (236)
- Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. (1995) (231)
- Protease-Activated Receptor 2 Mediates Eosinophil Infiltration and Hyperreactivity in Allergic Inflammation of the Airway1 (2002) (225)
- Characterization of Antisera Specific to NK1, NK2, and NK3 Neurokinin Receptors and their Utilization to Localize Receptors in the Rat Gastrointestinal Tract (1996) (213)
- Biased Signaling of Protease-Activated Receptors (2014) (207)
- Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. (2002) (207)
- Skin-nervous system interactions. (1996) (205)
- Thrombin and mast cell tryptase regulate guinea‐pig myenteric neurons through proteinase‐activated receptors‐1 and −2 (1999) (193)
- Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. (1999) (184)
- Trypsin IV, a Novel Agonist of Protease-activated Receptors 2 and 4* (2004) (182)
- Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA Receptors (1997) (181)
- Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. (1999) (180)
- The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. (2014) (179)
- Mast cell tryptase and proteinase‐activated receptor 2 induce hyperexcitability of guinea‐pig submucosal neurons (2003) (174)
- Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system (2010) (172)
- Trafficking of Proteinase-activated Receptor-2 and β-Arrestin-1 Tagged with Green Fluorescent Protein (1999) (169)
- Interactions of the skin and nervous system. (1997) (165)
- The control of microvascular permeability and blood pressure by neutral endopeptidase (1997) (159)
- Cellular sites of expression of the neurokinin‐1 receptor in the rat gastrointestinal tract (1995) (158)
- Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1 (2008) (155)
- Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. (1998) (152)
- Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. (1994) (148)
- Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. (2003) (145)
- Agonists of proteinase‐activated receptor 1 induce plasma extravasation by a neurogenic mechanism (2001) (142)
- Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4* (2014) (142)
- c-Cbl Mediates Ubiquitination, Degradation, and Down-regulation of Human Protease-activated Receptor 2* (2005) (141)
- Protease-activated receptor 2: activation, signalling and function. (2003) (139)
- Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. (2005) (137)
- Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. (2002) (135)
- Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice (2017) (134)
- Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. (2008) (132)
- Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain* (2015) (130)
- Proinflammatory role of proteinase‐activated receptor‐2 in humans and mice during cutaneous inflammation in vivo (2003) (127)
- Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling* (2013) (126)
- Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief (2017) (125)
- Protease-activated receptors: how proteases signal to cells to cause inflammation and pain. (2006) (123)
- The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation (2015) (119)
- Protease-activated receptors: novel PARtners in innate immunity. (2007) (116)
- Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. (2010) (114)
- Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin‐1 receptor in rats and mice (2000) (113)
- Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission (2017) (110)
- Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization. (1999) (109)
- American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and Comparative Physiology American Journal of Physiology: Renal, Fluid and Electrolyte (2003) (108)
- Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. (2006) (106)
- G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch (2015) (106)
- Trypsin IV or Mesotrypsin and p23 Cleave Protease-activated Receptors 1 and 2 to Induce Inflammation and Hyperalgesia* (2007) (105)
- Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. (2015) (104)
- Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome (2018) (103)
- Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. (2006) (103)
- Protease-activated receptors: how proteases signal to cells. (2001) (102)
- Localization of calcitonin receptor‐like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat (2005) (101)
- Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor. (1999) (99)
- Neutral Endopeptidase Terminates Substance P-Induced Inflammation in Allergic Contact Dermatitis1 (2001) (98)
- VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P. (1999) (98)
- Proteinase-Activated Receptor-2-Induced Colonic Inflammation in Mice: Possible Involvement of Afferent Neurons, Nitric Oxide, and Paracellular Permeability1 (2003) (97)
- Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase (1991) (94)
- A role for proteinase-activated receptor-1 in inflammatory bowel diseases. (2004) (92)
- Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors. (1997) (92)
- Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2 (2013) (91)
- Neurogenic inflammation. A model for studying efferent actions of sensory nerves. (1996) (90)
- Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor (*) (1995) (89)
- Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum (2015) (88)
- Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and β-arrestins (2007) (88)
- Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. (2007) (87)
- Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. (2003) (87)
- Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. (2010) (86)
- TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice (2018) (86)
- Neutral endopeptidase expression and distribution in human skin and wounds. (1999) (85)
- Recycling and Resensitization of the Neurokinin 1 Receptor (2004) (85)
- Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2* (2009) (84)
- Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract (1996) (83)
- Identification of Potential Tyrosine-containing Endocytic Motifs in the Carboxyl-tail and Seventh Transmembrane Domain of the Neurokinin 1 Receptor* (1997) (83)
- Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. (2003) (82)
- Protease-activated receptors (2002) (81)
- Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling (2007) (80)
- The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts* (2013) (78)
- Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. (2011) (78)
- Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function. (1998) (78)
- Dynamin and Rab5a-dependent Trafficking and Signaling of the Neurokinin 1 Receptor* (2001) (76)
- Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. (2011) (75)
- Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling (2016) (74)
- A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain (2019) (74)
- Basolateral proteinase‐activated receptor (PAR‐2) induces chloride secretion in M‐1 mouse renal cortical collecting duct cells (1999) (73)
- Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome. (2011) (73)
- The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence. (1994) (73)
- Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors. (2018) (72)
- Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor. (1999) (72)
- Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1* (2007) (72)
- Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. (2014) (72)
- Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs. (2006) (72)
- Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABAB receptors (1999) (71)
- Ubiquitin-dependent Down-regulation of the Neurokinin-1 Receptor* (2006) (71)
- Intestinal type 2 proteinase-activated receptors: expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport. (2000) (69)
- Neuro‐humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract (2014) (68)
- Heterologous regulation of trafficking and signaling of G protein-coupled receptors: β-Arrestin-dependent interactions between neurokinin receptors (2002) (68)
- Transient Receptor Potential Vanilloid (TRPV-1) Promotes Neurogenic Inflammation in the Pancreas Via Activation of the Neurokinin-1 Receptor (NK-1R) (2005) (65)
- Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Mediates Post-endocytic Trafficking of Protease-activated Receptor 2 and Calcitonin Receptor-like Receptor* (2007) (65)
- Neutral endopeptidase inhibition in diabetic wound repair (2002) (65)
- Substance P Regulates Th1-Type Colitis in IL-10 Knockout Mice1 (2003) (64)
- Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine. (1993) (63)
- Basolateral PAR‐2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon (2002) (63)
- Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells. (1994) (62)
- Pungent General Anesthetics Activate Transient Receptor Potential-A1 to Produce Hyperalgesia and Neurogenic Bronchoconstriction (2010) (62)
- Neurogenic plasma leakage in mouse airways (1999) (61)
- Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. (2013) (60)
- Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression. (2019) (60)
- Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. (2011) (60)
- Neutral endopeptidase activity is increased in the skin of subjects with diabetic ulcers. (2002) (60)
- N-Glycosylation Determines Ionic Permeability and Desensitization of the TRPV1 Capsaicin Receptor* (2012) (59)
- Endosomal Endothelin-converting Enzyme-1 (2009) (57)
- Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S (2012) (56)
- Proteinase-activated receptors: a growing family of heptahelical receptors for thrombin, trypsin and tryptase. (1999) (55)
- Protease-activated receptors: protease signaling in the gastrointestinal tract. (2004) (54)
- Mechanisms of protease‐activated receptor 2‐evoked hyperexcitability of nociceptive neurons innervating the mouse colon (2007) (54)
- Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage (2004) (54)
- The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. (2003) (53)
- Impaired pain sensation in mice lacking prokineticin 2 (2006) (53)
- Inhibition of gastric and pancreatic secretion in dogs by CGRP: role of somatostatin. (1989) (52)
- Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. (2007) (52)
- Stimulation of proteinase‐activated receptor 2 excites jejunal afferent nerves in anaesthetised rats (2003) (49)
- Catabolism of gastrin releasing peptide and substance P by gastric membrane-bound peptidases (1985) (48)
- Proteinase-activated receptor-2: physiological and pathophysiological roles. (2003) (47)
- Protease-activated receptors: the role of cell-surface proteolysis in signalling. (2002) (47)
- Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. (2013) (47)
- Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via β-Arrestin-2-Mediated Cross-Talk (2014) (47)
- Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons. (2001) (46)
- Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain (2020) (46)
- GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation (2014) (45)
- Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner* (2015) (43)
- Proteinase-activated Receptor-2 Induces Cyclooxygenase-2 Expression through β-Catenin and Cyclic AMP-response Element-binding Protein* (2008) (43)
- GPCR‐mediated EGF receptor transactivation regulates TRPV4 action in the vasculature (2015) (42)
- Endothelin-converting enzyme-1 degrades internalized somatostatin-14. (2008) (42)
- Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. (2019) (42)
- Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum. (1997) (41)
- Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors. (2000) (40)
- P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells* (2015) (40)
- Protein kinase C-mediated desensitization of the neurokinin 1 receptor. (2001) (40)
- A Role for Calcitonin Gene‐Related Peptide in Protection Against Gastric Ulceration (1994) (39)
- Rab 5 a and rab 11 a mediate agonist-induced trafficking of protease-activated receptor 2 (2003) (39)
- CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. (2011) (38)
- Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity (2019) (38)
- The tyrosine kinase inhibitor bafetinib inhibits PAR2‐induced activation of TRPV4 channels in vitro and pain in vivo (2014) (38)
- Proteinase-Activated Receptors: New Functions for Old Enzymes. (1998) (38)
- Human corneal epithelial cells express functional PAR-1 and PAR-2. (2002) (38)
- Neural Regulation of Endothelial Cell-Mediated Inflammation (2000) (36)
- Active cathepsins B, L, and S in murine and human pancreatitis. (2012) (36)
- Endothelin‐converting enzyme‐1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones (2011) (36)
- Dopamine and norepinephrine in the alimentary tract changes after chemical sympathectomy and surgical vagotomy. (1985) (36)
- Neurokinin 1 receptor distribution in cholinergic neurons and targets of substance P terminals in the rat nucleus accumbens (2000) (35)
- Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin. (1988) (35)
- Characterization of receptors using cyanine 3-labeled neuropeptides (1995) (34)
- Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons* (2013) (33)
- Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites* (2014) (33)
- Postsecretory metabolism of peptides (1987) (33)
- Somatostatin inhibits pancreatic exocrine secretion via a neural mechanism. (1990) (33)
- Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors. (1993) (31)
- Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease‐activated receptor 2 (2009) (31)
- Human mast cell proteases hydrolyze neurotensin, kinetensin and Leu5-enkephalin (1991) (31)
- Canine bombesin‐like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog. (1985) (31)
- Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1* (2012) (31)
- Differences in Receptor Binding and Stability to Enzymatic Digestion Between CCK-8 and CCK-58 (2002) (31)
- Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. (2012) (30)
- Serine proteases mediate inflammatory pain in acute pancreatitis. (2011) (30)
- Measurement of prostaglandin E2 in interstitial fluid from the dog stomach after feeding and indomethacin. (1983) (29)
- Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis (2016) (28)
- Legumain is activated in macrophages during pancreatitis. (2016) (28)
- Cigarette smoke – induced neurogenic inflammation is mediated by α , β-unsaturated aldehydes and the TRPA 1 receptor in rodents (2008) (28)
- Substance P inhibits pancreatic exocrine secretion via a neural mechanism. (1999) (27)
- G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease (2017) (27)
- Serine proteases and protease‐activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants (2014) (27)
- Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission (2015) (26)
- Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. (2011) (26)
- Identification of neuropeptide-degrading enzymes in the pancreas (1992) (26)
- Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice (2022) (25)
- Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation. (2017) (25)
- Metabolism of gastrin and cholecystokinin by endopeptidase 24.11 from the pig stomach. (1988) (24)
- The stressed gut: contributions of intestinal stress peptides to inflammation and motility. (2005) (24)
- Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse (2003) (23)
- Endothelin-converting Enzyme 1 and β-Arrestins Exert Spatiotemporal Control of Substance P-induced Inflammatory Signals* (2014) (23)
- Catabolism of substance P and neurotensin in the rat stomach wall is susceptible to inhibitors of angiotensin converting enzyme (1986) (22)
- Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors. (1993) (21)
- Evidence that PAR‐1 and PAR‐2 mediate prostanoid‐dependent contraction in isolated guinea‐pig gallbladder (2000) (21)
- Inflammation-associated changes in DOR expression and function in the mouse colon. (2018) (21)
- Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease (2019) (20)
- Catabolism of neurotensin in interstitial fluid of the rat stomach. (1984) (20)
- Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. (2008) (20)
- Distribution and abundance of neutral endopeptidase (EC 3.4.24.11) in the alimentary tract of the rat. (1993) (20)
- Isolation of a neuropeptide-degrading carboxypeptidase from the human stomach. (1992) (20)
- CGRP stimulates the release of pro-somatostatin-derived peptides from the gastric fundus. (1990) (20)
- The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma. (1984) (20)
- Mechanisms attenuating cellular responses to neuropeptides: extracellular degradation of ligands and desensitization of receptors. (1997) (19)
- Trafficking and signaling of G protein-coupled receptors in the nervous system: implications for disease and therapy. (2010) (19)
- Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects (2021) (19)
- Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane* (2016) (19)
- A role for proteinase-activated receptor-1 in inflammatory bowel diseases. (2004) (18)
- G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases. (2019) (17)
- Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals. (2018) (17)
- Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2 (2020) (17)
- Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig. (2016) (17)
- Neural regulation of endothelial cell-mediated inflammation. (2008) (17)
- Neutral endopeptidase determines the severity of pancreatitis-associated lung injury. (2005) (17)
- Protease-Activated Receptors: Mechanisms by Which Proteases Sensitize TRPV Channels to Induce Neurogenic Inflammation and Pain (2007) (16)
- Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2 (2016) (16)
- Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system. (2015) (16)
- Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system (2020) (16)
- Degradation of endogenous heptadecapeptide gastrin by endopeptidase 24.11 in the pig. (1987) (16)
- Co‐expression of μ and δ opioid receptors by mouse colonic nociceptors (2018) (16)
- Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain (2021) (15)
- Agonist-induced endocytosis of rat somatostatin receptor 1. (2007) (15)
- Expression of the neurokinin type 1 receptor in the human colon (2006) (15)
- Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. (2007) (14)
- Substance P-induced Trafficking of β-Arrestins (1999) (14)
- Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease. (2013) (14)
- Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons. (2008) (13)
- Neural and hormonal mechanisms mediate the enterogastric reflex: a study in intestinal transplants in rats. (1991) (13)
- Immunocytochemical localization of gastric inhibitory peptide and glucagon in the alimentary tract of ruminants. (1986) (13)
- Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanisms in rats. (1992) (13)
- Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (2014) (13)
- Stimulation by low phosphorus and low calcium diets of duodenal absorption of phosphate in betamethasone-treated chicks. (1981) (13)
- Nanotechnology for pain management: Current and future therapeutic interventions (2021) (13)
- Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain (2020) (12)
- Isolation of Endopeptidase-24.11 (EC 3.4.24.11, "Enkephalinase") From the Pig Stomach (1988) (11)
- Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury. (2002) (11)
- Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. (2014) (11)
- Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon (2014) (11)
- Actions of somatostatins on gastric smooth muscle cells. (1992) (11)
- Selective Release of Somatostatin by Calcitonin Gene—Related Peptide and Influence on Pancreatic Secretion a (1992) (11)
- Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells. (1991) (10)
- Catabolism of neurotensin in the epithelial layer of porcine small intestine (1987) (10)
- Catabolism of substance P in the stomach wall of the rat. (1985) (9)
- Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro. (2003) (9)
- Catabolism of bombesin in the interstitial fluid of the rat stomach (1983) (8)
- The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability (2020) (8)
- A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes (2021) (8)
- Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models (2021) (8)
- Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin (2016) (8)
- Contributions of Bile Acids to Gastrointestinal Physiology as Receptor Agonists and Modifiers of Ion Channels. (2021) (7)
- Application of a sulfoxonium ylide electrophile to generate cathepsin X-selective activity-based probes. (2020) (7)
- G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future. (2016) (7)
- Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe (2015) (6)
- An American Physiological Society cross-journal Call for Papers on "Inter-Organ Communication in Homeostasis and Disease". (2021) (6)
- Peptide G protein-coupled receptors meet at Erice. (1998) (6)
- The localization of gastrin-like immunoreactivity (GIR) in the alimentary tract of the sheep. (1984) (6)
- Metabolism of enkephalin in stomach wall of rats. (1990) (6)
- Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. (2014) (6)
- Corrigendum: Biased Signaling of Protease-Activated Receptors (2015) (6)
- Oral cancer induced TRPV1 sensitization is mediated by PAR2 signaling in primary afferent neurons innervating the cancer microenvironment (2022) (6)
- A proteinase-activated receptor subtype 2 (PAR-2) agonist stimulates mesenteric afferent nerve discharge (2000) (6)
- An American Physiological Society cross-journal Call for Papers on "Deconstructing organs: Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models". (2020) (6)
- Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: peripheral interaction between vagal and spinal afferents? (2014) (6)
- MECHANISMS REGULATING THE RESPONSIVENESS OF CELLS TO SUBSTANCE P : CELL-SURFACE DEGRADATION OF SUBSTANCE P AND NK-1 RECEPTOR ENDOCYTOSIS (1994) (5)
- Chromatographic and immunochemical studies on postsecretory processing of gastrin in the pig. (1986) (5)
- Intestinal activation of proteinase-activated receptor 1 (PAR1) reduces visceral nociception associated to rectal distension (RD) in rats (2003) (5)
- Characterization of an antibody to the human melatonin mt1 receptor. (2001) (5)
- Protease-Activated Receptors in Health and Disease. (2022) (5)
- Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain–associated conditions (2019) (5)
- Mechanisms by which Lipid Derivatives and Proteinases Signal to Primary Sensory Neurons: Implications for Inflammation and Pain (2003) (5)
- G protein-coupled receptors in gastrointestinal physiology. II. Regulation of neuropeptide receptors in enteric neurons. (1998) (5)
- Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. (2019) (5)
- Stimulation of the neurokinin 3 receptor activates protein kinase Cε and protein kinase D in enteric neurons (2008) (4)
- Metabolism and inactivation of gastrin releasing peptide by endopeptidase-24.11 in the dog. (1989) (4)
- Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain (2022) (4)
- Protease-activated receptor 2 sensitizes TRPV 1 by protein kinase C ε-and A-dependent mechanisms in rats and mice (2017) (4)
- II. Regulation of neuropeptide receptors in enteric neurons. (1998) (4)
- G protein-coupled receptor signaling: implications for the digestive system. (1997) (4)
- Rat dorsal root ganglion (DRG) neurons express proteinase activated receptors (PARS) 1 and 2 (2000) (4)
- Endocrine cells in the alimentary tract of the sheep. (1979) (4)
- Effects of Cholecystokinin and Gastrin Antagonists on Pancreatic Exocrine Secretion Stimulated by Gastrin‐Releasing Peptide (1992) (4)
- Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2 (2019) (4)
- Erratum (Retracted article): A role for proteinase-activated receptor-1 in inflammatory bowel diseases (Journal of Clinical Investigation (2004) 114 (1444-1456) DOI:10.1172/JCI200421689) (2006) (4)
- Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain. (2022) (3)
- 202 Hydrogen Sulfide (H2S) Inhibits Bile Acid Receptor TGR5-Mediated GLP-1 Release From Enteroendrocrine Cells: Possible Involvement of H2S in Altered Glucose Metabolism in Diabetes (2012) (3)
- Activation and internalization of the μ-opioid receptor (MOR) by endomorphin-1 and -2 (1998) (3)
- Erratum to “Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury” [Free Radic. Biol. Med. 43 (2007) 581–589] (2007) (3)
- Antibodies: friend or foe? (2015) (3)
- Proteinase-activated receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (3)
- 512 The Transient Receptor Potential (Trp) Ion Channels TRPA1 and TRPV4 Mediate Inflammatory Pain in the Pancreas (2008) (3)
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice (2021) (3)
- The role of neuropeptides in regulating airway function. Postsecretory metabolism of peptides. (1987) (2)
- Detection of naturally expressed receptors for gastrin-releasing peptide and tachykinins using cyanine 3-labelled neuropeptides (1996) (2)
- 34 – Inhibitory Mechanisms of the Exocrine Pancreas (1990) (2)
- 1085 – Neuronal Serotonin As a Link Between Depression and Constipation: A Role for Simultaneous Treatment with a Novel Slow-Release Formulation of the Serotonin Precursor, 5-Hydroxytryptophan (2019) (2)
- Antibodies to the rat substance P receptor: production and characterization (1992) (2)
- Aspirated bile acids affect lung immunity and function (2019) (2)
- Cysteine Proteases in Supernatants From Colonic Biopsies Obtained From Diarrhea-Predominant IBS Patients Evoke Sustained Hyperexcitability of Colonic Dorsal Root Ganglia Neurons (2011) (2)
- Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2 (2022) (2)
- Targeting of Transient Receptor Potential Channels in Digestive Disease (2015) (2)
- Cell Surface Receptors: Mechanisms of Signaling and Inactivation (1999) (2)
- A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS (2019) (2)
- Mechanisms That Attenuate Signaling By Regulatory Peptides (1999) (1)
- 519 Neutrophil Elastase Activates a PAR2/TRPV4 Signaling Complex to Cause Inflammatory Pain (2015) (1)
- Mediators of Chronic Stress and Tissue Proteases Interact to Potentiate the Excitability of Colonic Nociceptive Dorsal Root Ganglia Neurons in a Model of Post-Infectious IBS (2011) (1)
- Neutral endopeptidase (NEP) expression in normal human skin and in selected disease states (1998) (1)
- INVOlVeMeNT Of PrOTeINASe-AcTIVATeD recePTOr-2 IN SPONTANeOUS ScrATchING Of MIce WITh ATOPy-lIKe DerMATITIS ( P 15 ) (2007) (1)
- INVOlVeMeNT Of PrOTeINASe-AcTIVATeD recePTOr-2 IN SPONTANeOUS ScrATchING Of MIce WITh ATOPy-lIKe DerMATITIS ( P 15 ) (2007) (1)
- Catabolism of substance P in the rat stomach (1985) (1)
- Inhibition of nitric oxide synthesis prevents nonadrenergic, noncholinergic relaxation of human esophageal circular muscle (1992) (1)
- Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling (2022) (1)
- TGR5 agonists induce peripheral and central hypersensitivity to bladder distension (2022) (1)
- Proteolytic activation of the human epithelial sodium channel by trypsin and trypsin IV involves distinct cleavage sites (1181.2) (2014) (1)
- Insights for Targeting Disorders of Sensation and Inflammation Transient Receptor Potential Channel Axis: Molecular (2015) (1)
- Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S (2012) (1)
- 860 The TGR5 Receptor Mediates the Effects of Bile Acids on Intestinal Motility in Mice (2012) (1)
- Expression and potential functions of proteinase activated receptor-2 (PAR-2) in pancreatic acinar cells (1998) (1)
- 702 Transient Receptor Potential Ankyrin-1 (TRPA1) Has a Major Role in Visceral Pain (2009) (1)
- Proteinase-activated receptors (PARs) on myenteric neurons: Activation by thrombin and mast cell tryptase* (1998) (1)
- 155 Protein Kinase D1 Regulates Agonist-Evoked Translocation of Protease-Activated Receptor-2 From the Golgi Apparatus to the Plasma Membrane (2015) (1)
- CHAPTER 3 – Transmembrane Signaling by G Protein–Coupled Receptors (2006) (1)
- Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon (2014) (1)
- CGRP Signals from Endosomes of Schwann Cells to Elicit Migraine Pain (2021) (1)
- Functional Expression of TRPV4 in the Mouse Colon (2017) (1)
- Up-Regulated by Substance P Microvascular Endothelial Cells Is Directly VCAM-1 Expression on Human Dermal (1999) (1)
- Protease-activated receptor-2 (PAR-2) in human skin: Mast cell tryptase activates keratinocytes and endothelial cells through PAR-2 (1998) (1)
- Protease-Activated Receptors in Gastrointestinal Function and Disease (2006) (1)
- Oxide, and Paracellular Permeability Involvement of Afferent Neurons, Nitric Colonic Inflammation in Mice: Possible Proteinase-Activated Receptor-2-Induced (2003) (1)
- A role for calcitonin gene-related peptide-containing neurons in gastric cytoprotection (1989) (1)
- 431 Protease-Activated Receptor 2 Signals from Endosomes to Control Sensitivity of Nociceptors (2016) (0)
- A Novel G-Protein Coupled Receptor Responsive to Bile Acids Regulates Intestinal Motility (2011) (0)
- 182 Inflammation-Associated Changes in Delta Opioid Receptor Function and Distribution in the Mouse Colon (2016) (0)
- 1 G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases Short Title : GPCRs and Digestive Disease (2019) (0)
- The Mechanism and Function of Agonist-Induced Trafficking of Tachykinin Receptors (2004) (0)
- Trafficking of neurokinin receptors: regulation, mechanism and function (2008) (0)
- 782 β-Arrestin2 and Endothelin-Converting Enzyme-1 Control Substance P-Mediated Inflammatory Signaling and Colitis in Mice (2012) (0)
- Unraveling the Identity of Active Serine Proteases in Inflammatory Bowel Diseases (2017) (0)
- neurokinin 1 receptor Protein kinase C-mediated desensitization of the (2016) (0)
- W1730 Attenuation of Colonic Afferent Nerve Recordings But Not Visceromotor Response in Acute Citrobacter rodentium Colitis (2009) (0)
- SIGNALING-ARRESTIN-DEPENDENT ERK β Enzyme-1 : A REGULATOR OF Endosomal Endothelin-converting Mechanisms of Signal Transduction : (2009) (0)
- S1705 Corticotropin-Releasing Factor (CRF) and Urocortin 1 (UCN1) Differentially Regulate Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 (CRF-R1) (2010) (0)
- Proteinase-activated receptors in GtoPdb v.2021.3 (2021) (0)
- Aroleforproteinase-activatedreceptor-1ininflammatoryboweldiseases (2006) (0)
- Mo1638 Agonist- and Peptidase-Dependent Regulation of Somatostatin Receptor 2A Trafficking in Myenteric Neurons of the Mouse (2012) (0)
- Tu1247 DELTA OPIOID RECEPTOR SIGNALING IN ENDOSOMES: A NOVEL THERAPEUTIC TARGET FOR TREATING VISCERAL PAIN (2020) (0)
- Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (2014) (0)
- Distribution of neurokinin type 1 receptor in neurons and interstitial cells of cajal of the human distal colon (2003) (0)
- Mo1778 Agonist-Dependent Delta Opioid Receptor Trafficking and Signaling in Myenteric Neurons (2014) (0)
- Su1546 Mu and Delta Opioid Receptors are Co-expressed by Myenteric Neurons of the Mouse Intestine (2016) (0)
- Mice Expressing Fluorescent Protease‐Activated Receptor‐2 as a Novel Tool to Visualize Intracellular Receptor Trafficking (2020) (0)
- 934 Neurotensin-Induced Tumor Formation Is Regulated by Neurotensin Receptor 1 (NTR1)/MicroRNA-133a-Associated NTR1 Recycling Involving the Negative Regulator Zinc Finger E-Box-Binding Homeobox 1 (ZEB1) (2013) (0)
- Abstract 2696: Distinct roles for clathrin and dynamin in real-time TrkA trafficking and NGF-induced pain (2023) (0)
- Tachykinins 2005 Meeting (2006) (0)
- Substance P modulation of human dermal microvascular endothelial cell vascular cell (HDMEC) adhesion molecule-1 (VCAM-1) expression and function (1998) (0)
- Dynamin, B-arrestin and Rab5a mediated trafficking and signaling of the neurokinin 1 receptor (NK-1R) (2000) (0)
- Bile Acids Aspiration Modulates Cholinergic and Serotonergic Responses of the Distal Airways (2018) (0)
- Compensatory Induction of Cgrp in Cystic Fibrosis Airways Alters the Biologic Properties of the Submucosal Gland Progenitor Cell Niche (2011) (0)
- Protein kinase c (PKC)-induced desensitization of the neurokinin 1 receptor (NK1R): Diminished desensitization of a naturally occurring truncated receptor (2000) (0)
- Su1892 Cystatin C Attenuates Cathepsin S-Evoked and PAR2-Mediated Inflammation and Pain (2015) (0)
- Endothelin‐converting enzyme‐1 (ECE‐1)‐dependent trafficking of corticotropin‐releasing factor receptor 1 (CRF‐R1). (2010) (0)
- T1439 Reactive Prostaglandins (PG) Activate Transient Receptor Potential (TRP) A1 On Nociceptive Neurons to Induce Pain (2008) (0)
- Improving Cellular Uptake and Endosomal Targeting of Neurokinin 1 Receptor Antagonists (2017) (0)
- 993 Expression and Function of the Bile Acid Receptor GpBAR1 in the Enteric Nervous System (2009) (0)
- 401 Compartmentalized Delta Opioid Receptor Signaling in Sensory Neurons (2014) (0)
- 675 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT SELECTIVELY INHIBITS COLONIC INFLAMMATORY PAIN (2021) (0)
- Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (2017) (0)
- S1798 Protease-Activated Receptor 2 (PAR2) Directly Activates Transient Receptor Potential (TRP) Vanilloid 1 and 4 Channels to Induce Neurogenic Inflammation (2010) (0)
- 386 Endothelin Converting Enzyme-1 (ECE-1) Degrades Substance P (SP) in Endosomes and Regulates Mitogenic Signaling of the Neurokinin 1 Receptor (NK1R) (2008) (0)
- A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS (2018) (0)
- Localization and identification of protease activity in acute pancreatitis using in vivo molecular imaging (2010) (0)
- CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. (2015) (0)
- Activated Cathepsin S is a Biomarker and Therapeutic Target in Experimental Colitis (2017) (0)
- 214 Protein Phosphatase 2a (PP2A) and β-Arrestin1 Mediate Recycling-Independent Resensitization of the Neurokinin 1 Receptor (NK1R) (2010) (0)
- Endothelin converting enzyme 1 degrades internalized somatostatin (2018) (0)
- Neuroinin 1 and 2 receptors in murine enteric primary afferent neurons (2003) (0)
- Role of Neutral Endopeptitidase (NEP) and Substance P in Cutaneous Inflammation: Increased Plasma Extravasation in NEP-Deficient Mice. (2001) (0)
- The neuropathic pain mediator Cathepsin S (CatS) promotes activation of nociceptive pathways in mouse pancreas (2011) (0)
- Characterisation of rat mesenteric afferent responses to ligands selective at protease-activated receptor (PAR)-1, -2 and -4 (2003) (0)
- Mo1876 A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways (2015) (0)
- S156 Neurocutaneous interactions-general aspects (1997) (0)
- A213 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT IS SELECTIVELY ACTIVATED IN ACIDIC INFLAMMATORY ENVIRONMENTS (2020) (0)
- Rab5a and dynamin GTPases mediate substance P (SP)-induced trafficking of the neurokinin-1 receptor (NK-1R) (2000) (0)
- Measurement of gastric secretion in the conscious rat (1981) (0)
- 39. Transient Receptor Potential A1 (TRPA1) Mediates Pancreatic Inflammatory Pain (2008) (0)
- RAB4a‐ and RAB11a‐dependent recycling and resensitization of the neurokinin 1 receptor (2008) (0)
- The role of cutaneous neutral endopeptidase (NEP) and neuropeptides in modulating inflammatory responses in the skin (1998) (0)
- A novel cell surface receptor responsive to bile acids mediates itch (2010) (0)
- Mo1101 Beta-Arrestins and Endothelin-Converting Enzyme-1 Activity Mediate Neurotensin-Induced PRO-Inflammatory Signaling in Human Colonocytes (2012) (0)
- 152 Endosomal Platforms for Signaling Pain (2015) (0)
- The onset and chronicity of experimental colitis is modulated by pro-inflammatory peptides (1998) (0)
- Protease-activated receptors (PAR)-1 and-4 mediated stimulation of rat intestinal afferent sensitivity (2003) (0)
- Mo1604 - Colonic Proteases Evoke Sustained Pain Signaling via a Novel Endosomal Pathway in Neurons (2018) (0)
- W1167 Fluorescence Molecular Tomographic (FMT) Imaging of Protease Activities and Integrins in the Inflamed Gastrointestinal Tract of Mice (2010) (0)
- B-Arrestin-dependent endocytosis of the neurokinin 1 receptor (NK1R) is required for activation of p42/44 map kinases (2000) (0)
- pancreatitis Active cathepsins B , L , and S in murine and human (2012) (0)
- Substance P (SP)-induced desensitization of the neurokinin-1 receptor (NK1-R) and trafficking of G-protein receptor kinases (GRK) and β-arrestin in neurons* (1998) (0)
- neural mechanism Substance P inhibits pancreatic exocrine secretion via a (2016) (0)
- 2017 AGA Council Section Research Mentor Awardees (2017) (0)
- Proteases in Colonic Tissue from IBS Patients Evoke Sustained Excitability of Nociceptive DRG Neurons via Endosomal Signaling (2017) (0)
- Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2 (2022) (0)
- infected mouse nematode the onset of intestinal inflammation in the Neutral endopeptidase (EC 3.4.24.11) downregulates (2009) (0)
- New Editorial Team (2015) (0)
- Acknowledgment to reviewers (1996) (0)
- Hydrolysis of procine gastrin in vitro and in vivo by endopeptidase 24.11 (enkephalinase) (1985) (0)
- Title Impaired pain sensation in mice lacking prokineticin 2 Permalink (2006) (0)
- Mo1873 The Impact of Internalization on Compartmentalized Signaling of the Delta Opioid Receptor (2015) (0)
- 216 The Bile Acid Receptor GpBAR1 is Regulated by β-Arrestin-Independent Mechanisms and Transactivates the Epidermal Growth Factor Receptor Within Plasma Membrane Microdomains (2010) (0)
- PROTEASE-ACTIVATED RECEPTORS: NOVEL FUNCTIONS FOR SERINE PROTEASES (1999) (0)
- Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice (2017) (0)
- 896 Protease-Activated Receptor 2 Activates Transient Receptor Potential Vanilloid 4 by SRC Kinase-Mediated Tyrosine Phosphorylation (2012) (0)
- Sa1840 Endogenous Opioids Evoke a Sustained Antinociceptive Effect via Endosomal Signaling in Nociceptive DRG Neurons (2016) (0)
- Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo (2003) (0)
- Mo1732 Detection of Active Cathepsin S Using a Novel Activity-Based Probe in Dextran Sulfate Sodium Colitis (2015) (0)
- A201 ENDOGENOUS OPIOIDS AND NANOPARTICLES TARGETING SIGNALING FROM DELTA OPIOID RECEPTORS IN ENDOSOMES INDUCE SUSTAINED INHIBITION OF NOCICEPTIVE AFFERENT NERVES INNERVATING THE INFLAMED MOUSE COLON (2020) (0)
- 966 Localization and Function of Fluorescently-Tagged Delta Opioid Receptor (DOR) Expressed in Enteric Neurons of Knockin Mice (2010) (0)
- 699 The Role of Endothelin Converting Enzyme 1 (ECE1) in Intestinal Inflammation (2009) (0)
- 387 Endosomal Deubiquitinating Enzymes (DUBS) Control Ubiquitination and Post-Endocytic Sorting of Protease-Activated Receptor 2 (PAR2) (2008) (0)
- The contribution of endocytosis to sensitization of nociceptors and synaptic transmission in nociceptive circuits. (2022) (0)
- Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function. (1998) (0)
- Tu1879 Legumain Is a Novel Biomarker and Therapeutic Target in Inflammatory Bowel Disease (2016) (0)
- 242: A NOVEL PH-SENSITIVE OPIOID PROVIDES SUSTAINED ANALGESIA DURING COLONIC INFLAMMATION AND LACKS COMMON SIDE EFFECTS (2022) (0)
- Use of small intestine transplantation to study the mechanisms involved in the enterogastric reflex in rats (1990) (0)
- 562 Protein Kinase D and Gβγ Mediate Protease-Biased Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane (2016) (0)
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice. (2021) (0)
- T1429 Protease Activated Receptor 2 Sensitizes Transient Receptor Potential Vanilloid 4 On Mouse Colonic Dorsal Root Ganglia Neurons (2008) (0)
- T1764 Endothelin Converting Enzyme-1 (ECE-1) Promotes Recycling and Resensitization of the Substance P (SP) Neurokinin 1 Receptor (NK1R) in Enteric Neurons (2010) (0)
- Mo1637 Inflammation and β-Arrestin-Mediated Trafficking of the Neurokinin 1 Receptor in Myenteric Neurons of Mouse Colon (2012) (0)
- Enzymesated Receptors: New Functions for Old (2016) (0)
- 392 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT IS SELECTIVELY ACTIVATED IN ACIDIC INFLAMMATORY ENVIRONMENTS (2020) (0)
- Agonists of proteinase activated receptor 2 (PAR2) increase the excitability of guinea pig ileal myenteric neurons (2001) (0)
- T1438 Endosomal Endothelin Converting Enzyme-1 (ECE-1) Controls Resensitization the Proinflammatory and Nociceptive Effects of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) (2008) (0)
- 677 Serine and Cysteine Proteases in the Inflamed Murine Colon: Detection and Imaging Using Activity-Based Probes, and Causative Role in Inflammatory Pain (2010) (0)
- Tu1963 The Bile Acid Receptor TGR5 Sensitizes the TRPA1 Channel to Induce Cholestatic Itch (2014) (0)
- S1620 Trafficking of Corticotropin-Releasing Factor Receptors in Epithelial Cells in Response to Urocortin 1 (2009) (0)
- Su1893 Colonic Inflammation Induces Upregulation and Activation of the Delta Opioid Receptor, Which Ameliorates Colitis (2015) (0)
- Su1887 – Endogenous Opioids in Chronic Colitis Induce Sustained Antinociceptive Effect Via an Opioid Receptor - Compartmentalized Endosomal Signaling Pathway (2019) (0)
- Transient receptor potential vanilloid 1, substance P and reactive oxygen species mediate ethanol – induced gastric injury in mice (2008) (0)
- The role of pro-inflammatory peptides in the onset of intestinal inflammation (1998) (0)
- Proteinase-activated receptor-2 stimulates CCK secretion via Gq/11 and PLC/cPLA2 pathways: Evidence for positive feedback regulation of pancreatic secretion (2003) (0)
- Role of proteinases and proteinase‐activated receptors in pain pathways (2008) (0)
- Bunnett named editor of AJP–GI (2015) (0)
- Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (2017) (0)
- 400 Cathepsin S Induces Inflammation and Pain via Biased Agonism of PAR2 and TRPV4 (2014) (0)
- Heterologous desensitization and trafficking of neurokinin 1 and 3 receptors (NK1R, NK3R) (2000) (0)
- 889 Cathepsin Activity in Pancreatitis: Imaging, Identification and Contribution to Disease (2010) (0)
- This information is current as Dermatitis P-Induced Inflammation in Allergic Contact Neutral Endopeptidase Terminates Substance (2000) (0)
- PAR2 agonists evoke long-term exeitation in submucosal neurons in guinea pig lleum (2001) (0)
- 650 Localization and Function of Transient Receptor Potential (Trp) A1 Ion Channel in the Enteric Nervous System (2008) (0)
- Immunocytochemical identification of gastrin cells in the alimentary tract of the sheep [proceedings]. (1979) (0)
- 9 PS Protease-activated receptor-2 (PAR-2) and mast cell tryptase in irritable bowel syndrome (2002) (0)
- T1818 Profiling Protease Activation with Novel Activity-Based Probes in Experimental Acute Pancreatitis (2009) (0)
- Role of mast cells in surgically-induced gastro-intestinal ileus in mice* (1998) (0)
- Catabolism of substance P (SP1–11), and gastrin releasing peptide (GRP1–10) by membrane-bound peptidases of the stomach wall (1984) (0)
- neurons to chemical and electrical stimuli sensitizes cultured pulmonary vagal sensory (2015) (0)
- Protease-Activated Receptor 2 Mediates Eosinophil Infiltration and Hyperreactivity in Allergic Inflammation of the Airway 1 (2002) (0)
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- A45 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT SELECTIVELY INHIBITS NOCICEPTION IN DSS-INDUCED COLITIS (2021) (0)
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- The Mechanism and Function of Agonist-Induced Trafficking of G-protein Coupled Receptors (2000) (0)
- Knockout Mice Substance P Regulates Th1-Type Colitis in IL-10 (2003) (0)
- Mesotrypsin/Trypsin IV Expression and Role of Serine Protease Activity in Response to Pathogenic or Commensal Forms of E. coli (2011) (0)
- NMDA receptors are present in primary afferent fibers in the gut (2000) (0)
- cAMP/PKA Signaling Pathway in Vagal Sensory Neurons: Role of 2 Enhanced by PGE Transient Evoked by Chemical Stimulation Is (2015) (0)
- Heterologous regulation of signaling and trafficking of the neurokinin-1 and neurokinin-3 receptors (2000) (0)
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What Schools Are Affiliated With Nigel W Bunnett?
Nigel W Bunnett is affiliated with the following schools:
