Nikolaus Rajewsky | Academic Influence

Nikolaus Rajewsky's AcademicInfluence.com Rankings

Nikolaus Rajewsky

Biology

#1330

World Rank

#2253

Historical Rank

Systems Biology

#10

World Rank

#10

Historical Rank

Molecular Biology

#313

World Rank

#318

Historical Rank

biology Degrees

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Biology

Nikolaus Rajewsky's Degrees

PhD Molecular Biology Humboldt University of Berlin

Why Is Nikolaus Rajewsky Influential?

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According to Wikipedia, Nikolaus Rajewsky is a German system biologist at the Max-Delbrück-Center for Molecular Medicine and at the Charité in Berlin. He founded and directs the “Berlin Institute for Medical Systems Biology” . He leads the Rajewsky lab, where he studies how RNA regulates gene expression. He also co-chairs LifeTime, a pan-European research initiative of more than 90 academic institutions and 70 companies, which aims to revolutionize healthcare by mapping, understanding, and targeting cells during disease progression. LifeTime integrates several technologies: single-cell multiomics, machine learning, and personalized disease models such as organoids. Rajewsky has received numerous awards and honors, including the most prestigious German award, the Gottfried Wilhelm Leibniz Prize, endowed with 2.5 million euros by the German Research Foundation .

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Nikolaus Rajewsky's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Circular RNAs are a large class of animal RNAs with regulatory potency (2013) (5820)
Combinatorial microRNA target predictions (2005) (4715)
Silencing of microRNAs in vivo with ‘antagomirs’ (2005) (3953)
Widespread changes in protein synthesis induced by microRNAs (2008) (3471)
circRNA biogenesis competes with pre-mRNA splicing. (2014) (2181)
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades (2011) (2112)
A pancreatic islet-specific microRNA regulates insulin secretion (2004) (2061)
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. (2015) (1656)
Regulation of the Germinal Center Response by MicroRNA-155 (2007) (1553)
The evolution of gene regulation by transcription factors and microRNAs (2007) (1493)
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis (2017) (1446)
circBase: a database for circular RNAs (2014) (1213)
Translation of CircRNAs (2017) (1176)
Discovering microRNAs from deep sequencing data using miRDeep (2008) (1129)
microRNA target predictions in animals (2006) (1121)
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project (2010) (931)
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment (2020) (894)
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function (2017) (836)
A human snoRNA with microRNA-like functions. (2008) (786)
Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. (2015) (783)
Cell-type-specific signatures of microRNAs on target mRNA expression. (2006) (675)
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells (2019) (641)
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. (2011) (623)
Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage (2008) (617)
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. (2003) (546)
Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer (2004) (527)
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation (2014) (518)
Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood (2015) (515)
microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets (2005) (483)
Natural selection on human microRNA binding sites inferred from SNP data (2006) (476)
MicroRNA profiling of the murine hematopoietic system (2005) (471)
A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans (2006) (453)
Circadian Regulation of Gene Expression Systems in the Drosophila Head (2001) (442)
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb (2007) (383)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb (2007) (352)
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes (2010) (329)
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity (2014) (328)
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. (2004) (327)
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics (2018) (325)
The Translational Landscape of the Human Heart (2019) (303)
The Drosophila embryo at single-cell transcriptome resolution (2017) (301)
The Impact of miRNA Target Sites in Coding Sequences and in 3′UTRs (2011) (271)
The Landscape of C. elegans 3′UTRs (2010) (270)
Unambiguous identification of miRNA:target site interactions by different types of ligation reactions. (2014) (265)
Transcriptional Control in the Segmentation Gene Network of Drosophila (2004) (262)
Computational identification of microRNA targets (2004) (241)
Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo (2002) (241)
Modeling the Initiation and Progression of Human Acute Leukemia in Mice (236)
The Asymmetric Exclusion Process: Comparison of Update Procedures (1997) (235)
A map of human circular RNAs in clinically relevant tissues (2017) (234)
Competition between target sites of regulators shapes post-transcriptional gene regulation (2014) (230)
Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development (1987) (225)
doRiNA: a database of RNA interactions in post-transcriptional regulation (2011) (197)
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex (2017) (181)
Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (170)
Cell fixation and preservation for droplet-based single-cell transcriptomics (2017) (166)
Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. (2016) (159)
Gene expression cartography (2019) (157)
In vivo and transcriptome-wide identification of RNA binding protein target sites. (2011) (155)
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. (2014) (153)
Extensive identification and analysis of conserved small ORFs in animals (2015) (152)
RNA localization is a key determinant of neurite-enriched proteome (2017) (150)
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells (2012) (142)
High-resolution profiling and discovery of planarian small RNAs (2009) (141)
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy (2021) (139)
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells (2017) (136)
Exact Solution of a Cellular Automaton for Traffic (1998) (126)
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. (2011) (123)
Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis. (2018) (122)
Deep conservation of microRNA-target relationships and 3'UTR motifs in vertebrates, flies, and nematodes. (2006) (121)
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients (2020) (119)
Computational identification of microRNA targets. (2004) (110)
The evolution of DNA regulatory regions for proteo-gamma bacteria by interspecies comparisons. (2002) (109)
DoRiNA 2.0—upgrading the doRiNA database of RNA interactions in post-transcriptional regulation (2014) (107)
A Variety of Dicer Substrates in Human and C. elegans (2014) (106)
Conservation of regulatory elements between two species of Drosophila (2003) (102)
A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. (2018) (100)
The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway. (2016) (94)
Conservation of mRNA and protein expression during development of C. elegans. (2014) (93)
Large scale sorting of C. elegans embryos reveals the dynamics of small RNA expression (2009) (89)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (87)
FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control (2019) (87)
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 (2021) (86)
A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer (2004) (79)
Deciphering the porcine intestinal microRNA transcriptome (2010) (79)
The SNF2‐like helicase HELLS mediates E2F3‐dependent transcription and cellular transformation (2012) (74)
Probabilistic clustering of sequences: Inferring new bacterial regulons by comparative genomics (2002) (72)
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program (2019) (71)
Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (70)
Translational regulation shapes the molecular landscape of complex disease phenotypes (2015) (69)
Global characterization of the oocyte‐to‐embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism (2014) (68)
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation (2013) (66)
Spatial particle condensation for an exclusion process on a ring (1999) (64)
Select microRNAs are essential for early development in the sea urchin. (2012) (63)
Paternal RNA contributions in the Caenorhabditis elegans zygote (2014) (58)
Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function (2015) (58)
modENCODE Project Genome by the Caenorhabditis elegans Integrative Analysis of the (2011) (57)
The Human Cell Atlas White Paper (2018) (55)
Exact solution of an exclusion process with three classes of particles and vacancies (1999) (51)
miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim (2015) (50)
Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians (2016) (44)
A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain. (2020) (44)
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts (2020) (41)
Exact results for one-dimensional cellular automata with different types of updates (1996) (39)
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome (2021) (39)
The asymmetric exclusion model with sequential update (1996) (37)
Tracing tumorigenesis in a solid tumor model at single-cell resolution (2020) (36)
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection (2017) (35)
Correlating Gene Expression Variation with cis-Regulatory Polymorphism in Saccharomyces cerevisiae (2010) (35)
Binding site discovery from nucleic acid sequences by discriminative learning of hidden Markov models (2014) (32)
Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention (2020) (32)
Roles of Long Noncoding RNAs and Circular RNAs in Translation. (2018) (30)
The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation (2013) (29)
L(ou)sy miRNA targets? (2006) (29)
NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport (2021) (28)
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7 (2019) (28)
Spatiotemporal m(i)RNA Architecture and 3' UTR Regulation in the C. elegans Germline. (2018) (26)
Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo (2017) (25)
The transcriptome dynamics of single cells during the cell cycle (2019) (22)
RNA-bioinformatics: Tools, services and databases for the analysis of RNA-based regulation. (2017) (22)
microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes (2015) (22)
Single-Molecule Fluorescence In Situ Hybridization (FISH) of Circular RNA CDR1as. (2018) (21)
Identification of proteins and miRNAs that specifically bind an mRNA in vivo (2019) (21)
RCAS: an RNA centric annotation system for transcriptome-wide regions of interest (2017) (21)
SMASHing regulatory sites in DNA by human-mouse sequence comparisons (2003) (19)
Post-transcriptional Regulation by 3' UTRs Can Be Masked by Regulatory Elements in 5' UTRs. (2018) (18)
Best practice standards for circular RNA research (2022) (17)
Insm 1 cooperates with Neurod 1 and Foxa 2 to maintain mature pancreatic b-cell function (2015) (16)
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data (2020) (15)
Reexamining microRNA Site Accessibility in Drosophila: A Population Genomics Study (2009) (15)
Charting a tissue from single-cell transcriptomes (2018) (14)
MicroRNAs and the Operon paper. (2011) (13)
Cell type diversity in a developing octopus brain (2022) (12)
Anomalous roughening in three-dimensional polynucleation growth (1990) (11)
SURF1 mutations causative of Leigh syndrome impair human neurogenesis (2019) (11)
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting (2021) (9)
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat (2019) (9)
Essentials of miRNA-dependent control of mRNA translation and decay, miRNA targeting principles, and methods for target identification (2017) (8)
MicroRNAs are deeply linked to the emergence of the complex octopus brain (2022) (8)
Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients. (2020) (7)
Predicting cellular position in the Drosophila embryo from Single-Cell Transcriptomics data (2019) (7)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (7)
A deterministic sandpile automaton revisited (1999) (7)
Spacemake: processing and analysis of large-scale spatial transcriptomics data (2021) (7)
SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution (2022) (6)
Parallel genetics of regulatory sequences using scalable genome editing in vivo. (2021) (6)
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury (2022) (6)
The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer’s disease-like pathology by perturbing oligodendrocyte survival and neuronal homeostasis (2021) (6)
Spatio-temporal, optogenetic control of gene expression in organoids (2022) (6)
Neurodegeneration in human brain organoids infected with herpes simplex virus type 1 (2021) (5)
Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy (2020) (5)
Nuclei Isolation from Adult Mouse Kidney for Single-Nucleus RNA-Sequencing. (2021) (5)
Estimation of C. elegans cell- and tissue volumes (2021) (5)
Characterization of Transcription Termination-Associated RNAs: New Insights into their Biogenesis, Tailing, and Expression in Primary Tumors (2018) (4)
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury. (2022) (4)
Optogenetic perturbations of RNA expression in tissue space (2021) (4)
Rapid nuclear deadenylation of mammalian messenger RNA (2021) (3)
Computional prediction of microRNA targets in vertebrates, fruitflies and nematodes (2008) (3)
Plant Epigenetics (2017) (3)
Mixed messages: Re-initiation factors regulate translation of animal mRNAs (2014) (3)
Image-based representation of massive spatial transcriptomics datasets (2021) (3)
Kurzbiographien (2018) (2)
Generation of Human Brain Organoids for Mitochondrial Disease Modeling. (2021) (2)
Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program (2019) (2)
Regulation of spatial and temporal gene expression in an animal germline (2018) (2)
A Probabilistic Cellular Automaton for Evolution (1995) (2)
Global characterization of the oocyte-to-embryo transition in C . elegans uncovers a novel mRNA clearance mechanism (2014) (2)
COVID-19 infection dynamics revealed by SARS-CoV-2 wastewater sequencing analysis and deconvolution (2021) (2)
Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (2)
Identification of Transcription Factor EGL-27::GFP Binding Regions in L1 (2011) (1)
Identification of Transcription Factor LIN-15B::GFP Binding Regions in L3 (2011) (1)
A guide to naming eukaryotic circular RNAs (2023) (1)
Full-length poly(A) and mRNA sequencing (FLAM-seq) (2019) (1)
Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects underlying impaired adult neurogenesis (2018) (1)
Identification of Transcription Factor GEI-1::GFP Binding Regions in L4 (2011) (1)
SMASHing regulatory sites in DNA by human. (2003) (1)
Optocoder: computational decoding of spatially indexed bead arrays (2022) (1)
Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology (2022) (1)
Inhibition of miR-182 decreases OVA-induced arthritis in mice (2011) (1)
Transcriptomic responses of the human kidney to acute injury at single cell resolution (2021) (1)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (1)
XII Annual Meeting of the Interuniversity Institute of Myology (2016) (1)
MicroRNA-182 promotes clonal expansion of activated T helper cells (2010) (1)
MicroRNA-182 is induced by IL-2 and promotes clonal expansion of 1 activated helper T lymphocytes 2 (2019) (0)
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury (2022) (0)
Inferring geometric embeddings for single cell data (2019) (0)
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex (2017) (0)
Author response: Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians (2016) (0)
Gene expression cartography (2019) (0)
A map of human circular RNAs in clinically relevant tissues (2017) (0)
A3.19 The miR-148a is Induced by TWIST1 and TBET and Promotes the Survival of Effector Memory T Helper 1 Lymphocytes by Regulating the Proapoptotic Gene BIM (2013) (0)
miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner (2023) (0)
RNA as a regulator of gene expression in our brain: from circular RNAs to single cell sequencing (2017) (0)
Post-transcriptional Regu lation by 3 0 UTRs Can Be Masked by Regulatory Elements in 5 0 UTRs (0)
Parallel genetics of regulatory sequences in vivo (2020) (0)
C. elegans Gene Regulatory Alleles and Reporter Bashing Studies (2023) (0)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (0)
Identification of Transcription Factor MEP-1::GFP Binding Regions in Embryos (2011) (0)
Decoding the genome- computational identification of microRNA targets (2005) (0)
Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy. (2022) (0)
Cell fixation and preservation for droplet-based single-cell transcriptomics (2017) (0)
Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
Urinary single-cell sequencing captures intrarenal injury and repair processes in human acute kidney injury (2022) (0)
Genomes & Developmental Control Computational identification of microRNA targets (2004) (0)
ciRS-7-miR7 regulate ischemia induced neuronal death via glutamatergic signaling (2023) (0)
Identification of Transcription Factor CEH-30::GFP Binding Regions in Late Embyros (2011) (0)
Prox2+ and Runx3+ neurons regulate esophageal motility (2022) (0)
Session Introduction (2008) (0)
Sites of Transcription Initiation Drive mRNA Isoform Selection (2022) (0)
A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development (2023) (0)
MOESM2 of Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
Identifying MicroRNAs and their Targets (2007) (0)
Comprehensive identification and characterization of conserved small ORFs in animals (2015) (0)
Extensive identification and analysis of conserved small ORFs in animals (2015) (0)
Analysis of Intron Sequenc es Reveals Hallmarks of Circular RNA Biogenesis in Animals Graphical (2015) (0)
Tracing tumorigenesis in a solid tumor model at single-cell resolution (2020) (0)
A2.22 Microrna-31 modulates the expression of mobility related genes and the motility of T helper 1 lymphocytes (2016) (0)
Regulation of pathogenic effector/memory T helper 1 lymphocyte survival by microRNA (2012) (0)
MOESM11 of Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
Long-term imaging reveals behavioral plasticity during C. elegans dauer exit (2022) (0)
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection (2017) (0)
E-GEOD-25798.processed.2.zip (2011) (0)
MOESM7 of Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
Advanced Topics in Bioinformatics and Computational Biology (2013) (0)
Circular RNAs in the Mam malian Brain Are Highly Abundant , Conserved , and Dynamically Expressed Graphical (2015) (0)
Identification of microRNA Targets by Azra Krek (2009) (0)
MOESM14 of Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
MOESM13 of Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (0)
RBM 20 orchestrates pre-mRNA processing by targeting distinct intronic splicing silencers in the heart (2014) (0)
RNA localization is a key determinant of neurite-enriched proteome (2017) (0)
COMPUTATIONAL CHALLENGES IN THE STUDY OF SMALL REGULATORY RNAS (2007) (0)
E-GEOD-25798.additional.1.zip (2011) (0)
E-GEOD-25800.processed.1.zip (2011) (0)

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