Nir Barzilai
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(Suggest an Edit or Addition)Nir Barzilai's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Chronic inflammation in the etiology of disease across the life span (2019) (1434)
- The genetic architecture of type 2 diabetes (2016) (927)
- A nutrient-sensing pathway regulates leptin gene expression in muscle and fat (1998) (869)
- Functionally significant insulin-like growth factor I receptor mutations in centenarians (2008) (694)
- Metformin as a Tool to Target Aging. (2016) (656)
- The Critical Role of Metabolic Pathways in Aging (2012) (643)
- Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? (2002) (577)
- Unique lipoprotein phenotype and genotype associated with exceptional longevity. (2003) (562)
- The Hyperglycemia-induced Inflammatory Response in Adipocytes (2005) (516)
- Interventions to Slow Aging in Humans: Are We Ready? (2015) (462)
- Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis (2009) (407)
- Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1991) (402)
- Surgical removal of visceral fat reverses hepatic insulin resistance. (1999) (392)
- Leptin selectively decreases visceral adiposity and enhances insulin action. (1997) (365)
- Overfeeding rapidly induces leptin and insulin resistance. (2001) (348)
- Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action* (1997) (336)
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity (2009) (330)
- Undulating changes in human plasma proteome profiles across the lifespan (2019) (317)
- Role of the glucosamine pathway in fat-induced insulin resistance. (1997) (316)
- In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. (1995) (279)
- Pilot study of resveratrol in older adults with impaired glucose tolerance. (2012) (270)
- Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity (2005) (268)
- Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue* (2001) (262)
- Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. (1998) (254)
- Genome-wide analysis identifies 12 loci influencing human reproductive behavior (2016) (250)
- Benefits of Metformin in Attenuating the Hallmarks of Aging. (2020) (245)
- Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. (2011) (242)
- Extreme longevity is associated with increased serum thyrotropin. (2009) (235)
- Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease (2018) (233)
- Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians (2009) (231)
- Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes* (1998) (228)
- Motoric cognitive risk syndrome (2014) (222)
- Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. (1993) (207)
- Tissue‐specific dysregulation of DNA methylation in aging (2010) (207)
- Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans (2006) (206)
- Humanin: A Novel Central Regulator of Peripheral Insulin Action (2009) (198)
- Visceral adipose tissue modulates mammalian longevity (2008) (196)
- Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. (2007) (187)
- Clinical Phenotype of Families with Longevity (2004) (182)
- Differential gene expression between visceral and subcutaneous fat depots. (2002) (173)
- Glucose Regulates in Vivo Glucose-6-phosphatase Gene Expression in the Liver of Diabetic Rats (*) (1996) (173)
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup (2018) (172)
- Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of Rats* (2010) (172)
- Role of visceral adipose tissue in aging. (2009) (171)
- Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin. (1993) (171)
- Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity (2014) (164)
- Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers (2016) (164)
- Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats. (2008) (159)
- A meta-analysis of genome-wide association studies identifies multiple longevity genes (2019) (158)
- Plasma HDL levels highly correlate with cognitive function in exceptional longevity. (2002) (154)
- Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. (2019) (153)
- Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls (2019) (153)
- Revisiting the role of fat mass in the life extension induced by caloric restriction. (1999) (151)
- A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci (2012) (148)
- Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-α in adipose tissue (2002) (146)
- Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins (2014) (146)
- Leptin resistance during aging is independent of fat mass. (2002) (146)
- Efficacy and Safety of Sitagliptin Versus Glipizide in Patients With Type 2 Diabetes and Moderate-to-Severe Chronic Renal Insufficiency (2013) (145)
- Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. (2001) (143)
- Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction (2010) (140)
- Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene (*) (1995) (139)
- Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. (2009) (133)
- Induction of Hepatic Glucose-6-Phosphatase Gene Expression by Lipid Infusion (1997) (131)
- Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial (2011) (131)
- Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. (2004) (130)
- The Tissue Concentration of UDP-N-acetylglucosamine Modulates the Stimulatory Effect of Insulin on Skeletal Muscle Glucose Uptake* (1997) (129)
- Differential responses of visceral and subcutaneous fat depots to nutrients. (2005) (128)
- Adiponectin levels and genotype: a potential regulator of life span in humans. (2008) (127)
- Caloric restriction, body fat and ageing in experimental models (2004) (119)
- Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities (2007) (118)
- Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity (2015) (117)
- Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging (2007) (116)
- Offspring of Centenarians Have a Favorable Lipid Profile (2001) (115)
- Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. (2010) (104)
- Strategies and Challenges in Clinical Trials Targeting Human Aging (2016) (103)
- The insulin/IGF-1 signaling in mammals and its relevance to human longevity (2005) (103)
- Biological evidence for inheritance of exceptional longevity (2005) (102)
- Lifestyle Factors of People with Exceptional Longevity (2011) (100)
- The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. (2016) (98)
- A genotype of exceptional longevity is associated with preservation of cognitive function (2006) (98)
- Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. (1997) (96)
- RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans (2009) (96)
- The paradox of the insulin/IGF-1 signaling pathway in longevity (2004) (92)
- Carbon Flux via the Pentose Phosphate Pathway Regulates the Hepatic Expression of the Glucose-6-phosphatase and Phosphoenolpyruvate Carboxykinase Genes in Conscious Rats* (1998) (92)
- Genetics, lifestyle and longevity: Lessons from centenarians (2015) (90)
- Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice (2018) (90)
- The role of fat depletion in the biological benefits of caloric restriction. (2001) (89)
- Impaired IGF1R signaling in cells expressing longevity‐associated human IGF1R alleles (2011) (88)
- Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults (2018) (88)
- Searching for human longevity genes: the future history of gerontology in the post-genomic era. (2001) (88)
- Relationship between changes in body composition and insulin responsiveness in models of the aging rat. (1995) (87)
- The effect of leptin on Lep expression is tissue-specific and nutritionally regulated (1999) (86)
- Disease drivers of aging (2016) (84)
- Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. (2002) (84)
- System-wide Benefits of Intermeal Fasting by Autophagy. (2017) (83)
- Four Genome-Wide Association Studies Identify New Extreme Longevity Variants (2017) (81)
- Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. (2004) (79)
- Dose-Dependent Effects of Glyburide on Insulin Secretion and Glucose Uptake in Humans (1991) (78)
- Aging is associated with resistance to effects of leptin on fat distribution and insulin action. (2002) (77)
- Central and Opposing Effects of IGF-I and IGF-Binding Protein-3 on Systemic Insulin Action (2006) (73)
- Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity (2016) (73)
- APOE Alleles and Extreme Human Longevity (2018) (73)
- Interaction between Aging and Syndrome X: New Insights on the Pathophysiology of Fat Distribution (1999) (71)
- Insulin resistance and aging: a cause or a protective response? (2012) (69)
- Glucosamine-Induced Inhibition of Liver Glucokinase Impairs the Ability of Hyperglycemia to Suppress Endogenous Glucose Production (1996) (69)
- Disrupting Mitochondrial–Nuclear Coevolution Affects OXPHOS Complex I Integrity and Impacts Human Health (2014) (69)
- Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms (2003) (69)
- Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. (2009) (68)
- Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study. (2016) (67)
- Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (66)
- Aging as a Biological Target for Prevention and Therapy. (2018) (66)
- Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults (2017) (65)
- Hyperglycemia modulates angiotensinogen gene expression. (2001) (65)
- Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population (2016) (64)
- Motoric cognitive risk syndrome (2014) (64)
- Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats (2011) (63)
- Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. (2000) (62)
- Genetic studies reveal the role of the endocrine and metabolic systems in aging. (2010) (62)
- Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population (2010) (62)
- Serum heat shock protein 70 level as a biomarker of exceptional longevity (2006) (61)
- Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo (2007) (60)
- Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. (2002) (59)
- Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes (2016) (58)
- Surgical removal of visceral adipose tissue: Effects on insulin action (2003) (58)
- Exceptional longevity is associated with decreased reproduction (2011) (57)
- Potent humanin analog increases glucose‐stimulated insulin secretion through enhanced metabolism in the β cell (2013) (57)
- Screening Human Embryos for Polygenic Traits Has Limited Utility (2019) (57)
- Inflammatory peptides derived from adipose tissue (2005) (56)
- Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults. (2017) (54)
- Disease variants in genomes of 44 centenarians (2014) (54)
- Hepatic Overexpression of Insulin-like Growth Factor-II in Adulthood Increases Basal and Insulin-stimulated Glucose Disposal in Conscious Mice (*) (1996) (53)
- Insulin-Like Growth Factor Binding Protein-3 Induces Insulin Resistance in Adipocytes In Vitro and in Rats In Vivo (2007) (53)
- Enhanced activation of a “nutrient‐sensing” pathway with age contributes to insulin resistance (2008) (53)
- Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement. (2014) (51)
- Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults (2009) (51)
- Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes. (2014) (50)
- Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats. (1996) (49)
- Correlation between insulin clearance and insulin responsiveness: studies in normal, obese, hyperthyroid, and Cushing's syndrome patients. (1986) (48)
- A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. (2016) (47)
- Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal (1996) (47)
- The place of genetics in ageing research (2012) (47)
- Aging per se increases the susceptibility to free fatty acid-induced insulin resistance. (2010) (46)
- Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. (1999) (46)
- 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain. (2018) (45)
- Exceptional Parental Longevity Associated with Lower Risk of Alzheimer's Disease and Memory Decline (2010) (45)
- Development of clinical trials to extend healthy lifespan (2018) (45)
- Role of APOE genotype in gait decline and disability in aging. (2013) (45)
- A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk (2017) (43)
- Clinical Trials Targeting Aging and Age-Related Multimorbidity (2016) (42)
- The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan (2020) (42)
- Contribution of adipose tissue to health span and longevity. (2010) (40)
- Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians (2016) (40)
- Discordant Effects of Glucosamine on Insulin-stimulated Glucose Metabolism and Phosphatidylinositol 3-Kinase Activity* (1999) (39)
- The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature (2017) (38)
- Longevity genes: from primitive organisms to humans. (2003) (38)
- Human longevity and common variations in the LMNA gene: a meta‐analysis (2012) (36)
- Accretion of visceral fat and hepatic insulin resistance in pregnant rats. (2008) (36)
- Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline (2015) (36)
- Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. (1997) (36)
- Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study (2013) (35)
- The regulation of body fat distribution and the modulation of insulin action (2000) (35)
- Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience (2016) (35)
- Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. (2015) (34)
- Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity (2017) (34)
- Genetic landscape of APOE in human longevity revealed by high-throughput sequencing (2016) (34)
- Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. (2017) (33)
- Post-challenge hyperglycemia in older adults is associated with increased cardiovascular risk profile. (2009) (33)
- Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease (2012) (32)
- GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence (2014) (31)
- Expanded genetic screening panel for the Ashkenazi Jewish population (2015) (31)
- Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. (1995) (31)
- Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. (1999) (30)
- Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes (2020) (29)
- Positive attitude towards life and emotional expression as personality phenotypes for centenarians (2012) (29)
- ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups (2016) (28)
- Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. (2012) (28)
- Plasma proteomic profile of age, health span, and all‐cause mortality in older adults (2020) (27)
- Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional Longevity without compromise to muscle mass and function (2016) (26)
- Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats. (2000) (26)
- Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms (2016) (25)
- Phenotypes and genotypes of high density lipoprotein cholesterol in exceptional longevity. (2013) (25)
- The role of fat cell derived peptides in age-related metabolic alterations (2001) (25)
- ARDD 2020: from aging mechanisms to interventions (2020) (25)
- Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2017) (25)
- The effect of age-dependent increase in fat mass on peripheral insulin action is saturable. (1998) (24)
- Exploring the Promise of Resveratrol: Where Do We Go From Here? (2013) (24)
- Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies (2018) (24)
- Targeting senescence (2018) (23)
- Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion. (1995) (23)
- Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults (2020) (23)
- Genetics of extreme human longevity to guide drug discovery for healthy ageing (2020) (22)
- Personality, self-rated health, and cognition in centenarians: Do personality and self-rated health relate to cognitive function in advanced age? (2013) (22)
- The challenges in moving from ageing to successful longevity. (2013) (22)
- Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing (2013) (21)
- Geroscience in the Age of COVID-19 (2020) (21)
- Frailty and Risk of Incident Motoric Cognitive Risk Syndrome. (2019) (21)
- A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin (2020) (21)
- Insulin effects on glucose and potassium metabolism in vivo: evidence for selective insulin resistance in humans. (1991) (20)
- Association of exceptional parental longevity and physical function in aging (2014) (19)
- Insulin resistance in Cushing's syndrome. (1985) (18)
- Fat accretion and the regulation of insulin-mediated glycogen synthesis after puberty in rats. (1997) (18)
- TARGETING AGING WITH METFORMIN (TAME) (2017) (18)
- Ashkenazi Jewish Centenarians Do Not Demonstrate Enrichment in Mitochondrial Haplogroup J (2008) (17)
- Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. (2017) (17)
- Plasma proteomic profile of frailty (2020) (17)
- Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. (2007) (17)
- Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults (2020) (16)
- IGF-1 : The Jekyll & Hyde of the aging brain (2018) (16)
- High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation (2018) (16)
- Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population (2017) (16)
- The antagonistic pleiotropy of insulin‐like growth factor 1 (2021) (16)
- Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging (2006) (16)
- Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition (2016) (16)
- Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension. (2010) (15)
- Individuals with Exceptional Longevity Manifest a Delayed Association Between Vitamin D Insufficiency and Cognitive Impairment (2014) (15)
- Food Deprivation Limits Insulin Secretory Capacity in Postpubertal Rats (2001) (15)
- Lack of suppression of insulin secretion by hyperinsulinemia in a patient with an insulinoma. (1986) (15)
- Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty (2018) (15)
- Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series (2019) (14)
- Insulin resistance and acanthosis nigricans: evidence for a postbinding defect in vivo. (1990) (14)
- Latest advances in aging research and drug discovery (2019) (14)
- The influence of gender on inheritance of exceptional longevity (2015) (14)
- Aging Health and R&D for Healthy Longevity Must Be Included into the WHO Work Program (2018) (13)
- Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility (2022) (13)
- Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation (2021) (12)
- Intracellular Pathways of Insulin-Mediated Glucose Uptake before and after Puberty in Conscious Rats1 (1997) (12)
- Creating the Next Generation of Translational Geroscientists (2019) (12)
- Treatment of Diabetes Mellitus in Older People: Oral Therapy Options (2003) (12)
- Rare genetic coding variants associated with human longevity and protection against age-related diseases (2021) (12)
- Perinephric and Epididymal Fat Affect Hepatic Metabolism in Rats (2012) (12)
- Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. (2016) (12)
- The Rationale for Delaying Aging and the Prevention of Age-Related Diseases (2012) (11)
- A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production. (2016) (11)
- Pennington Scientific Symposium on Mechanisms and Retardation of Aging (2003) (11)
- Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia (2020) (11)
- Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in Ashkenazi Jews (2012) (11)
- Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers (2020) (11)
- Discovering the secrets of successful longevity. (2003) (11)
- Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging (2017) (10)
- Trajectories of frailty in aging: Prospective cohort study (2021) (10)
- Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. (2019) (10)
- Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization (2022) (9)
- Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes (2021) (9)
- A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin (1995) (9)
- Extending human healthspan and longevity: a symposium report (2021) (8)
- Suppression of insulin secretion by C-peptide infusion in humans. (1995) (8)
- Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes (2020) (8)
- Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. (2015) (8)
- Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility (2021) (8)
- Increased insulin responsiveness and insulin clearance in thyrotoxicosis. (1985) (8)
- New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins (2016) (8)
- Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance (2019) (8)
- Effect of Longevity Genetic Variants on the Molecular Aging Rate (2020) (8)
- Relative Trajectories of Gait and Cognitive Decline in Aging. (2021) (7)
- Elevated Common Variant Genetic Risk for Tourette Syndrome in a Densely Affected Pedigree (2021) (7)
- Genetic signature of human longevity in PKC and NF‐κB signaling (2021) (7)
- Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons (2021) (7)
- Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans (2009) (7)
- Obesity: age-associated weight gain and the development of disease. An interview with Nir Barzilai. Interview by Marc E. Weksler. (1999) (7)
- Case report: increased insulin sensitivity in tumor hypoglycemia in a diabetic patient: glucose metabolism in tumor hypoglycemia. (1991) (7)
- The Second International Conference “Genetics of Aging and Longevity” (2012) (7)
- Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries (2018) (6)
- Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants. (2012) (6)
- Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A (2020) (6)
- Einstein's institute for aging research: collaborative and programmatic approaches in the search for successful aging (2004) (6)
- Correlation between glucose disposal and amino acids levels in hyperthyroidism. (1993) (6)
- A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A (2021) (6)
- Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality (2021) (6)
- Association Between the Functional Variant of KLOTHO Allele and High-Density Lipoprotein Cholesterol , Blood Pressure , Stroke , and Longevity (2005) (6)
- Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation (2021) (5)
- Association between Sleep Patterns and Health in Families with Exceptional Longevity (2017) (5)
- Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population (2019) (5)
- Undulating changes in human plasma proteome across lifespan are linked to disease (2019) (5)
- Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century (2022) (4)
- Meeting Report: Aging Research and Drug Discovery (2022) (4)
- Sternoclavicular septic arthritis: a novel cause of pleural effusion. (1998) (4)
- Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2018) (4)
- New horizons in life extension, healthspan extension and exceptional longevity (2022) (4)
- Disruption of one allele of the murine glut 4 gene causes marked resistance to the action of insulin (1996) (4)
- Glucoregulatory hormone influence on hepatic glucose production in the elderly (2006) (3)
- PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects (2019) (3)
- Adiponectin levels and genotype (2008) (3)
- In vivo insulin action in hepatocellular and cholestatic liver cirrhosis (1991) (3)
- Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity (2020) (3)
- OR05-1 THE GROWTH HORMONE RECEPTOR EXON-3 DELETION IS A MARKER FOR EXCEPTIONAL LONGEVITY (2006) (3)
- Genetic Factors in Exceptional Longevity—Reply (2004) (3)
- Aging, Body Fat, and Carbohydrate Metabolism (2005) (2)
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup (2018) (2)
- Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes (2021) (2)
- EXPERIMENTAL IUGR INDUCES ALTERATIONS IN DNA METHYLATION AND GENE EXPRESSION IN PANCREATIC ISLETS OF RATS (2010) (2)
- Does the brain lead the metabolic decline in aging? Lessons from animal models and human centenarians (2003) (2)
- *100 Semi-supercentenarians and older as a proposed sample set for the Archon Genomics X PRIZE Validation Protocol* (2011) (2)
- A Regulatory Pathway for Medicines That Target Aging (2019) (2)
- Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes (2014) (2)
- Effect of Age on the Emergence of Insulin Resistance (2002) (2)
- Ef fi cacy and Safety of Sitagliptin Versus Glipizide in PatientsWith Type 2 Diabetes andModerate-to-Severe Chronic Renal Insuf fi ciency (2012) (2)
- Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats. Diabetes 2011;60:2691–2700 (2017) (2)
- Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span (2021) (1)
- Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing (2020) (1)
- Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey (2022) (1)
- High-depth whole genome sequencing of a large population-specific reference panel: Enhancing sensitivity, accuracy, and imputation (2017) (1)
- The voyage to healthy longevity: from experimental models to the ultimate goal (2005) (1)
- Genes for Exceptional Longevity (2014) (1)
- Faculty Opinions recommendation of Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. (2012) (1)
- The pathophysiology of diabetes in aging (1999) (1)
- The role of dietary patterns and exceptional parental longevity in healthy aging (2017) (1)
- ETHNIC-SPECIFIC EFFECT OF APOE ALLELES ON EXTREME LONGEVITY (2018) (1)
- 810: Differentially methylated Regions as targets of adverse intrauterine environment (2014) (1)
- The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span (2010) (1)
- Symposium : Calorie Restriction : Effects of Body Composition , Insulin Signaling and Aging The Role of Fat Depletion in the Biological Benefits of Caloric Restriction 1 , 2 (2001) (1)
- Integrity of hypothalamic–pituitary‐testicular axis in exceptional longevity (2022) (1)
- High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity (2022) (1)
- 204 Impact of maternal diet on peripheral vs hepatic insulin resistance in young female offspring (2011) (0)
- Genetic factors in exceptional longevity. Authors' reply (2004) (0)
- SA51THE LIMITS OF POLYGENIC EMBRYO SELECTION FOR COGNITIVE ABILITY (2019) (0)
- Exome-wide association studies in general and long-lived populations identify genetic variants related to human age (2020) (0)
- METFORMIN’S METABOLIC AND NON-METABOLIC EFFECTS LINKED TO AGING (2018) (0)
- Disease drivers of aging Which mechanisms do or do not drive aging in diabetics ? (2017) (0)
- Biological Age Acceleration and Motoric Cognitive Risk Syndrome. (2023) (0)
- Masthead: (Advanced Genetics 2/03) (2022) (0)
- A-17 Examining Cognitive Trajectories in SuperAgers within the LonGenity Study (2021) (0)
- Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome (2022) (0)
- 539: Hepatic and peripheral insulin resistance of pregnancy are not reversed in early postpartum rats (2008) (0)
- Erratum: Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion (Diabetes (1997) 46 (153-157)) (1997) (0)
- AN UPDATE ON ANTI-AGING DRUG TRIALS (2018) (0)
- INVESTIGATING DYNAMICS OF AGE-ASSOCIATED TRANSCRIPTIONAL NETWORKS WITH INTERVENTIONS TARGETING AGING (2019) (0)
- UNFOLDING THE SECRETS OF EXCEPTIONAL LONGEVITY (2018) (0)
- Marked Increase in the Ability of the β-Cells to Secrete Insulin in Response to Glucose and FFA Occurs Post-Puberty (1999) (0)
- Prevention of Fat Accretion through Puberty restores Insulin Action on Glycogen Synthesis to Prepubertal Levels in Conscious Rats. † 373 (1997) (0)
- Quantum Healthy Longevity for healthy people, planet, and growth. (2022) (0)
- Induced by Caloric Restrietion" (2010) (0)
- Proxy measures of cognitive reserve and trajectories of gait and cognitive decline in older adults (2022) (0)
- with a disrupted glucokinase allele Abnormal regulation of HGP by hyperglycemia in mice (2016) (0)
- Central regulation of peripheral insulin action (2009) (0)
- Trajectories of gait and cognitive decline in aging, and as a function of parental longevity and the motoric cognitive risk syndrome (2021) (0)
- Th-W54:2 Why metuselah lived to be 969: Longetivity genes and a novel lipoprotein connection (2006) (0)
- Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet, Diabetes, 59(11): 2898–2903. https://doi.org/10.2337/db10-0362 (2019) (0)
- Genetic variability in the cholesteryl ester transfer protein (CETP) gene may buffer the effect of APOE-ε4 on incidence of amnestic mild cognitive impairment (aMCI): Results for the Einstein Aging Study (EAS) (2012) (0)
- Masthead: (Advanced Genetics 1/03) (2022) (0)
- Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats. Diabetes 2011;60:2691–2700 (2017) (0)
- HOW TO PROVE THAT AGING CAN BE TAMED AND THAT APPROPRIATE REGULATION CAN BE FOLLOWED? (2018) (0)
- Faculty Opinions recommendation of Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. (2014) (0)
- HDL cholesterol levels mediate association of CETP genotype with mortality (2012) (0)
- Role of visceral fat in insulin resistance of pregnancy (2005) (0)
- The Hypothalamic-Pituitary-Testicular Axis in Exceptionally Old Men (2021) (0)
- Cerebral Small Vessel Disease and Gait Speed in Older Adults without Dementia (2022) (0)
- 212: Metabolic alterations in visceral fat and liver contribute to persistent insulin resistance early postpartum (2011) (0)
- Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies. (2022) (0)
- Why did Moses live to be 120 (2008) (0)
- A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations (2021) (0)
- Novel neuro‐regulation of peripheral metabolism in aging (2009) (0)
- Correction to: Effect of longevity genetic variants on the molecular aging rate (2021) (0)
- Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews (2015) (0)
- Advances in diabetes management: Application to the geriatric patient (2000) (0)
- Longevity genotype is associated with a reduced rate of memory decline and reduced incidence of dementia: Results from the Einstein Aging Study (2009) (0)
- A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A (2023) (0)
- LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING (2017) (0)
- Editorial Board: (Advanced Genetics 4/03) (2022) (0)
- Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. (1997) (0)
- Aging as a mechanism for type 2 diabetes mellitus (2018) (0)
- 377: MicroPET Imaging in pregnancy: a novel way to visualize and quantify in vivo glucose uptake in pregnancy (2011) (0)
- Editorial Board: (Advanced Genetics 3/03) (2022) (0)
- Genetics of extreme human longevity to guide drug discovery for healthy ageing (2020) (0)
- 38 Plasma proteomic signature of motoric cognitive risk syndrome (2023) (0)
- Decreased capacity to sustain glucose stimulated insulin secretion in aging rodents (2003) (0)
- Abstract ED04-02: The role of genes in protecting against age-related disease in cancer (2008) (0)
- ETHNICITY-SPECIFIC EXTREME LONGEVITY VARIANTS IN A CONSORTIUM OF FOUR CENTENARIAN STUDIES (2022) (0)
- Healthy Ashkenazi centenarians have higher serum TSH levels than healthy normal controls. (2009) (0)
- Prevalent skin cancer and conservative faith may be linked with cognitive impairment in Ashkenazi Jewish exceptionally long‐lived individuals (2020) (0)
- BIOMARKER STRATEGIES FOR GEROSCIENCE-GUIDED CLINICAL TRIALS (2019) (0)
- High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation (2018) (0)
- 600: Abnormal intrauterine growth induces global epigenetic changes in human stem cells (2008) (0)
- Body-mass index and mortality in a prospective cohort: Commentary (2000) (0)
- Guest Editorial Discovering the Secrets of Successful Longevity (2003) (0)
- To what extent is ageing genetic ? (2012) (0)
- Correction (2015) (0)
- Irving S. Wright Award of Distinction Lecture (2020) (0)
- Pregnancy alters adipose biology and its conribution to thrombosis, insulin action and inflammation (2006) (0)
- Fat accretion and the regulation of insulin-mediated glycogen synthesis after puberty in rats. (1997) (0)
- MEGA-ANALYSIS OF A CONSORTIUM OF FOUR CENTENARIAN STUDIES IDENTIFIES NOVEL EXTREME LONGEVITY VARIANTS (2022) (0)
- Masthead: (Advanced Genetics 4/12) (2021) (0)
- Association of exceptional parental longevity and physical function in aging (2014) (0)
- A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants (2022) (0)
- OR13-4 DIRECT, CENTRAL, AND OPPOSING EFFECTS OF IGF-1 AND IGFBP-3 ON SYSTEMIC INSULIN ACTION (2006) (0)
- Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice (2018) (0)
- Editorial Board: (Advanced Genetics 1/04) (2023) (0)
- Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (0)
- Cognitive reserve moderates the relationship between hippocampal volume and cognitive decline – but not gait decline (2022) (0)
- Genetic and Epigenetic Contributions to Longevity (2010) (0)
- Increased hepatic insulin resistance is detemined by visceral fat accretion and accumulation of hepatic triglycerides during pregnancy (2006) (0)
- Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls (2019) (0)
- Faculty Opinions recommendation of Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. (2013) (0)
- 51: Moderate voluntary running protects against hepatic insulin resistance and restores the placenta-pup glucose uptake gradient in diet-induced obese pregnant rats (2012) (0)
- Targeting senescence (2018) (0)
- OR6,1 Telomere length is associated with exceptional longevity and is modulated by the IGF system (2008) (0)
- Vincent Cristafalo Award Lecture (2020) (0)
- A metabolomic signature of the APOE2 allele (2022) (0)
- Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span. (2023) (0)
- Distinct Patterns of Brain Atrophy in MCR and amnestic MCI pre‐dementia syndromes (2022) (0)
- 717: Physiological insulin resistance of pregnancy leads to increased glucose uptake rat pups (2008) (0)
- 43: Recurrent pregnancy is associated with visceral adiposity and insulin resistance, but not beta-cell dysfunction in a rodent model (2007) (0)
- Original article Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial (2011) (0)
- Advances in the field of geroscience [Transcript]: (514942018-001) (2017) (0)
- INCREASED BURDEN OF RARE LOSS-OF-FUNCTION VARIANTS IN ALZHEIMER’S DISEASE PATIENTS COMPARED TO CENTENARIANS (2017) (0)
- Mechanism of Metf ormin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects* (2008) (0)
- Effect of Polygenic Risk Score on Alzheimer's Disease Risk Depends on Age and APOE4 Status (2020) (0)
- Irving S. Wright Award of Distinction Lecture, Vincent Cristafalo Award Lecture, and Terrie Fox Wetle Award Lecture (2021) (0)
- 233: Hexosamine biosynthetic pathway: does it contribute to insulin resistance of pregnancy? (2009) (0)
- Age-related changes in gait domains: Results from the LonGenity study. (2022) (0)
- 205: Sedentary behavior during pregnancy does not alter maternal fat distribution or insulin action (2011) (0)
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What Schools Are Affiliated With Nir Barzilai?
Nir Barzilai is affiliated with the following schools:
