Nissim Hay
#131,856
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Biochemistry researcher
Nissim Hay's AcademicInfluence.com Rankings
Nissim Haybiology Degrees
Biology
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#11897
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Molecular Biology
#1139
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#1165
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Biochemistry
#1294
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#1413
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Chemistry Biology
Nissim Hay's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
Why Is Nissim Hay Influential?
(Suggest an Edit or Addition)Nissim Hay's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Upstream and downstream of mTOR. (2004) (4165)
- The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. (1997) (1133)
- Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. (2001) (962)
- The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. (1999) (939)
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress (2012) (934)
- Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. (2001) (924)
- 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. (1998) (909)
- The pentose phosphate pathway and cancer. (2014) (891)
- Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (2003) (824)
- The two TORCs and Akt. (2007) (815)
- The Akt-mTOR tango and its relevance to cancer. (2005) (786)
- Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. (2008) (705)
- Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria (1999) (688)
- Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? (2016) (678)
- Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. (2013) (650)
- Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. (2004) (632)
- Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. (1994) (587)
- Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. (2009) (533)
- Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity* (2005) (530)
- Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt (2006) (501)
- Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo (2005) (427)
- Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3 (2001) (406)
- Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy (2013) (387)
- FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. (2010) (313)
- Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases (2004) (307)
- Activation of Akt/Protein Kinase B Overcomes a G2/M Cell Cycle Checkpoint Induced by DNA Damage (2002) (300)
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin (2018) (274)
- Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. (1998) (263)
- Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation. (1994) (260)
- Interplay between FOXO, TOR, and Akt. (2011) (259)
- Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2 (1993) (244)
- ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. (2013) (239)
- Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. (2006) (235)
- FoxM1, a critical regulator of oxidative stress during oncogenesis (2009) (230)
- Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. (2004) (229)
- Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling (2007) (225)
- Down‐regulation of Notch‐1 and Jagged‐1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF‐κB signaling pathways (2010) (220)
- The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. (2006) (214)
- Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line (1998) (208)
- FGF-dependent metabolic control of vascular development (2017) (207)
- Role of the Akt pathway in mRNA translation of interferon-stimulated genes (2008) (198)
- Akt1 governs breast cancer progression in vivo (2007) (195)
- c-Myc induces the expression and activity of ornithine decarboxylase. (1993) (172)
- Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death (2002) (171)
- Attenuation in the control of SV40 gene expression (1982) (151)
- Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB (1999) (146)
- Activation of NF-κB by Bradykinin through a Gαq- and Gβγ-dependent Pathway That Involves Phosphoinositide 3-Kinase and Akt* (2000) (140)
- Deregulation of FoxM1b leads to tumour metastasis (2011) (139)
- Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons* (2003) (139)
- Increased Hexokinase Activity, of Either Ectopic or Endogenous Origin, Protects Renal Epithelial Cells against Acute Oxidant-induced Cell Death* (2002) (136)
- The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts (2005) (129)
- A Phosphoinositide 3-Kinase-AKT-Nitric Oxide-cGMP Signaling Pathway in Stimulating Platelet Secretion and Aggregation* (2006) (128)
- The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. (2008) (128)
- Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc* (2004) (127)
- Sequence-specific transcriptional activation by Myc and repression by Max (1993) (122)
- Regulatory Effects of Mammalian Target of Rapamycin-activated Pathways in Type I and II Interferon Signaling* (2007) (122)
- Induction of Cell Cycle Progression and Acceleration of Apoptosis Are Two Separable Functions of c-Myc: Transrepression Correlates with Acceleration of Apoptosis (2000) (121)
- Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters (1993) (118)
- Neoplastic transformation by the human gene N-myc (1987) (118)
- Akt1 Signaling Regulates Integrin Activation, Matrix Recognition, and Fibronectin Assembly* (2007) (115)
- Akt isoforms differentially regulate neutrophil functions. (2010) (111)
- Regulatory elements that modulate expression of human c-myc. (1987) (109)
- Mitochondrial Hexokinases: Guardians of the Mitochondria (2005) (109)
- A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. (2005) (107)
- p21 Disrupts the interaction between cdk2 and the E2F-p130 complex (1996) (102)
- An important role for Akt3 in platelet activation and thrombosis. (2010) (99)
- A FOS protein is present in a complex that binds a negative regulator of MYC. (1989) (97)
- Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. (2004) (96)
- Akt as a target for cancer therapy: more is not always better (lessons from studies in mice) (2017) (92)
- A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function (2001) (91)
- Inhibition of Chk1 by Activated PKB/Akt (2004) (91)
- Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis (2018) (90)
- Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. (2016) (89)
- Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression (1997) (82)
- Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. (2003) (81)
- The double-edged sword of AMPK signaling in cancer and its therapeutic implications (2015) (80)
- Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo (2013) (77)
- Akt isoforms and glucose homeostasis – the leptin connection (2011) (77)
- The deficiency of Akt1 is sufficient to suppress tumor development in Pten mice (2006) (75)
- Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. (1996) (75)
- Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. (2018) (72)
- Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. (2012) (72)
- A kinetic analysis of the nucleotide-induced allosteric transitions of GroEL. (1999) (72)
- Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa (2018) (71)
- Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium (2016) (68)
- ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3&bgr; (2012) (66)
- Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma (2008) (65)
- Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. (2014) (65)
- Protein Kinase C-δ and Phosphatidylinositol 3-Kinase/Akt Activate Mammalian Target of Rapamycin to Modulate NF-κB Activation and Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Endothelial Cells* (2009) (65)
- The dark face of AMPK as an essential tumor promoter (2012) (65)
- Apoptosis Induced by Differentiation or Serum Deprivation in an Immortalized Central Nervous System Neuronal Cell Line (1996) (63)
- Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. (2011) (63)
- Identifying strategies to target the metabolic flexibility of tumours (2020) (60)
- Leptin Deficiency and Beta-Cell Dysfunction Underlie Type 2 Diabetes in Compound Akt Knockout Mice (2009) (59)
- mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition (2009) (55)
- Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. (2000) (55)
- AMPK as a therapeutic target in renal cell carcinoma (2010) (55)
- c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1* (2004) (55)
- p53 strikes mTORC1 by employing sestrins. (2008) (49)
- Mnk earmarks eIF4E for cancer therapy (2010) (49)
- Expression, regulation, and chromosomal localization of the Max gene. (1992) (49)
- Regulatory Effects of Mammalian Target of Rapamycin-mediated Signals in the Generation of Arsenic Trioxide Responses* (2008) (44)
- Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. (2005) (43)
- Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma (2015) (43)
- Control of late simian virus 40 transcription by the attenuation mechanism and transcriptionally active ternary complexes are associated with the nuclear matrix. (1984) (40)
- Akt Activation Emulates Chk1 Inhibition and Bcl2 Overexpression and Abrogates G2 Cell Cycle Checkpoint by Inhibiting BRCA1 Foci* (2010) (38)
- Akt-phosphorylated Mitogen-activated Kinase-activating Death Domain Protein (MADD) Inhibits TRAIL-induced Apoptosis by Blocking Fas-associated Death Domain (FADD) Association with Death Receptor 4* (2010) (38)
- PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer. (2013) (37)
- Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover (2016) (37)
- PI3K-AKT-FoxO axis in cancer and aging. (2011) (37)
- Distribution of mouse sulfated glycoprotein-1 (prosaposin) in the testis and other tissues. (1998) (36)
- Combination of oxidative stress and FOXM1 inhibitors induces apoptosis in cancer cells and inhibits xenograft tumor growth. (2013) (36)
- The effect Akt2 deletion on tumor development in Pten+/− mice (2011) (36)
- Attenuation of late simian virus 40 mRNA synthesis is enhanced by the agnoprotein and is temporally regulated in isolated nuclear systems (1985) (36)
- Hexokinase 2 as oncotarget (2013) (36)
- The role of RNA molecules in transduction of the proto-oncogene c-fps (1986) (33)
- The Akt1 Isoform Is Required for Optimal IFN-β Transcription through Direct Phosphorylation of β-Catenin (2012) (33)
- Site of premature termination of late transcription of simian virus 40 DNA: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. (1982) (32)
- Hepatic HKDC1 Expression Contributes to Liver Metabolism (2018) (30)
- Attenuation in SV40 as a mechanism of transcription-termination by RNA polymerase B. (1984) (28)
- Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation (2018) (26)
- Attenuation may regulate gene expression in animal viruses and cells. (1985) (26)
- Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus (2018) (24)
- Akt‐dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis (2012) (23)
- Hexokinase 2 is dispensable for T cell-dependent immunity (2018) (23)
- Immunohistochemical Expression of Components of the Akt-mTORC1 Pathway is Associated with Hepatocellular Carcinoma in Patients with Chronic Liver Disease (2008) (22)
- Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1. (2012) (20)
- Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin (2018) (18)
- In vitro premature termination in SV40 late transcription. (1983) (17)
- Transcription termination in animal viruses and cells. (1988) (17)
- Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy (2005) (17)
- Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer (2020) (15)
- Blockage of the Early Events of Mitogenic Signaling by Interferon-γ in Macrophages in Response to Colony-Stimulating Factor-1 (1995) (13)
- SV40 deletion mutant (d1861) with agnoprotein shortened by four amino acids. (1984) (13)
- MADD Is a Downstream Target of PTEN in Triggering Apoptosis (2014) (12)
- Cancer genomics: the post-transcriptional era. (2013) (12)
- Requirement of E. coli DNA synthesis functions for the lytic replication of bacteriophage P1. (1983) (11)
- Myc drives apoptosis in PC12 cells in the absence of Max (2001) (11)
- Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. (2015) (9)
- Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids. (2008) (9)
- A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis (2022) (8)
- Hexokinase II may be dispensable for CD4 T cell responses against a virus infection (2018) (8)
- Expanding the concepts of cancer metabolism (2018) (8)
- Erratum to Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer [Cancer Cell 24, (2004) 213-228] (2013) (8)
- Fuelling cancer cells (2018) (7)
- Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1. (1995) (7)
- Erratum: The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB (Experimental Cell Research (1999) 253:1 (210-229)) (2000) (6)
- p 21 Disrupts the Interaction between cdk 2 and the E 2 Fp 130 Complex (1996) (6)
- Efficient and accurate in vitro processing of simian virus 40-associated small RNA (1986) (4)
- Attenuation in the Control of Gene Expression in Animal Viruses (1984) (4)
- Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain (2020) (3)
- Identifying strategies to target the metabolic flexibility of tumours (2020) (3)
- Erratum: Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy (Drug Discovery Today: Disease Mechanism (2005) vol. 2 (2) (239-246) 10.1016/j.ddmec.2005.05.021) (2005) (2)
- Abstract 315: S100B regulates IL-6 signaling via the p90 ribosomal S6 kinase (RSK) in malignant melanoma (2017) (1)
- Vivo In and Wound Healing In Vitro Migration Circuit Essential for Promoting Skin Cell of LRP-1 Receptor to Akt 1 and Akt 2 : a through Subdomain II and the NPVY Motif Extracellular Heat Shock Protein 90 Signals (2013) (1)
- Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia (2019) (1)
- Neutrophil Akt2 Plays a Critical Role In Heterotypic Neutrophil-Platelet Interactions During Vascular Inflammation (2013) (1)
- Gadd45 (cid:1) mediates the protective effects of CD40 costimulation against Fas-induced apoptosis (2003) (1)
- Attenuation and modulation of mRNA secondary structure in a feedback control system regulating SV40 gene expression (1983) (1)
- Akt1 in Osteoblasts and Osteoclasts Controls Bone (2007) (1)
- Abstract 25: Neutrophil Akt2 Regulates Heterotypic Cell-Cell Interactions During Vascular Inflammation (2014) (0)
- The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling (2021) (0)
- Part 3: Targeting Cancer Pathways: Tumor Metabolism and Proliferation (2015) (0)
- Abstract IA07: Exploiting cancer metabolism for cancer therapy (2016) (0)
- Retraction. Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1. (1996) (0)
- Nucleic Acids Research (2003) (0)
- The double-edged sword of AMPK signaling in cancer and its therapeutic implications (2015) (0)
- University of Birmingham Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis (2018) (0)
- Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin (2018) (0)
- A novel non-catalytic scaffolding activity of Hexokinase 2 contributes to EMT and metastasis (2021) (0)
- Su1006 Nitrosative Stress Marker (iNOS) Is Positively Correlated With Hepatocellular Carcinoma Tumor Grade, Oxidative Damage Marker (O8HdG) and High Metabolic Marker (HK2) Levels (2013) (0)
- This information is current as-Catenin β Phosphorylation of Transcription through Direct β IFN-The Akt 1 Isoform Is Required for Optimal (2012) (0)
- Expanding the concepts of cancer metabolism (2018) (0)
- How to inhibit breast cancer and breast cancer metastasis with Akt inhibitors: Lessons learned from studies in mice (2022) (0)
- Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia (2023) (0)
- Author response: Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation (2018) (0)
- Molecular Pathways Molecular Pathways : Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy (2013) (0)
- mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3 (cid:2) Inhibition (cid:1) (2009) (0)
- Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover (2016) (0)
- CS3-1 Interplay between Akt, mTOR complexes, and FoxO (2010) (0)
- Progression of LNCaP Human Prostate Carcinoma Cells: Androgen Receptor Activity and c-myc Gene Expression (1996) (0)
- SS2-2 Roles of mTOR complexes in IFN-signaling and IFN-dependent biological responses (2010) (0)
- The Roles of Akt1 and Akt2 in GPIb-IX-Mediated Platelet Activation Signaling. (2007) (0)
- The Role of Akt3 in Mediating Outside-in Signaling of the Platelet Integrin αIIbβ3 (2011) (0)
- Heightened HKII Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma 1 Title : Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma (2015) (0)
- Editorial Board (2009) (0)
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin (2018) (0)
- [146] IMMUNOHISTOCHEMICAL EVIDENCE OF mTOR ACTIVITY IN HEPATOCELLULAR CARCINOMA (HCC) FROM LIVER EXPLANTS IS ASSOCIATED WITH HCC RECURRENCE AFTER LIVER TRANSPLANTATION (OLT) (2007) (0)
- A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis (2022) (0)
- Activation of the p 70 S 6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells (2004) (0)
- Hexokinase 2 is dispensable for T cell-dependent immunity (2018) (0)
- Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development. (2020) (0)
- The Role of Akt3 in Platelet Activation (2008) (0)
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What Schools Are Affiliated With Nissim Hay?
Nissim Hay is affiliated with the following schools: