Nobuhiro Harada
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Nobuhiro Harada's Degrees
- PhD Pharmacology University of Tokyo
- Doctorate Medicine University of Tokyo
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(Suggest an Edit or Addition)Nobuhiro Harada's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. (2004) (652)
- Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. (1993) (360)
- Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors (2009) (332)
- Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. (2005) (314)
- Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. (1998) (299)
- Aromatase in Human Bone Tissue (1997) (267)
- Brain aromatase is neuroprotective. (2001) (259)
- Aromatase immunoreactivity in axon terminals of the vertebrate brain. An immunocytochemical study on quail, rat, monkey and human tissues. (1996) (243)
- Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction (2005) (238)
- Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. (1998) (225)
- The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood (2002) (196)
- Distribution of aromatase in the brain of the Japanese quail, ring dove, and zebra finch: An immunocytochemical study (1990) (194)
- The Androgen Receptor Governs the Execution, but Not Programming, of Male Sexual and Territorial Behaviors (2010) (192)
- Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. (1996) (187)
- Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. (1994) (183)
- Immunocytochemical localization of aromatase in the brain (1990) (175)
- Stromal spindle cells contain aromatase in human breast tumors. (1994) (163)
- Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis. (1988) (157)
- Sexual Partner Preference Requires a Functional Aromatase (Cyp19) Gene in Male Mice (2002) (156)
- Localized expression of aromatase in human vascular tissues. (1999) (154)
- Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. (1994) (152)
- Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. (1999) (149)
- Aberrant expression of aromatase in breast cancer tissues (1997) (148)
- Structural characterization of the human estrogen synthetase (aromatase) gene. (1990) (147)
- Novel properties of human placental aromatase as cytochrome P-450: purification and characterization of a unique form of aromatase. (1988) (146)
- Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme (1995) (145)
- Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice (2004) (138)
- Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive “limbic ring” of the lateral septum-bed nucleus-amygdala complex (1993) (137)
- Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy. (1999) (134)
- Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. (1995) (132)
- Neuroanatomical specificity in the co-localization of aromatase and estrogen receptors. (1991) (131)
- Acute effects of oestrogen on the guinea pig and human IKr channels and drug‐induced prolongation of cardiac repolarization (2008) (130)
- Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus. (1996) (123)
- Mode of Action and Functional Significance of Estrogen-Inducing Dendritic Growth, Spinogenesis, and Synaptogenesis in the Developing Purkinje Cell (2007) (122)
- Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction. (1992) (119)
- Presence of alternatively spliced transcripts of aromatase gene in human breast cancer. (1996) (117)
- Brain aromatase expression after experimental stroke: Topography and time course (2005) (111)
- Bcl-2 gene is highly expressed during neurogenesis in the central nervous system. (1993) (109)
- Genetic variants of CYP19 (aromatase) and breast cancer risk (2000) (108)
- Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis (2014) (106)
- A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN). (2004) (106)
- Functional aromatase expression in porcine adrenal gland and testis. (1996) (105)
- Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. (1993) (104)
- Elevated steroid sulfatase expression in breast cancers (2000) (102)
- Expression and Cellular Localization of Estrogen Receptors α and β in the Human Fetus1 (2001) (100)
- Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone. (1992) (100)
- Alteration in Sex-Specific Behaviors in Male Mice Lacking the Aromatase Gene (2003) (99)
- A unique aromatase (P-450AROM) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts. (1992) (98)
- Synergism between androgens and estrogens in the induction of aromatase and its messenger RNA in the brain (1993) (96)
- Activation of Peroxisome Proliferator-Activated Receptor-γ and Retinoid X Receptor Inhibits Aromatase Transcription via Nuclear Factor-κB (2005) (94)
- Macrophages, estrogen and the microenvironment of breast cancer (1998) (88)
- Selective induction of two different molecular species of cytochrome P-450 by phenobarbital and 3-methylcholanthrene. (1981) (87)
- Genetic variants of CYP19 (aromatase) and breast cancer risk (2000) (86)
- Aromatase in hyperplasia and carcinoma of the human prostate (1997) (85)
- Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen. (1993) (84)
- Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency. (1992) (81)
- Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment (2010) (80)
- Aromatase as a cellular marker of testosterone action in the preoptic area (1992) (76)
- Human and quail aromatase activity is rapidly and reversibly inhibited by phosphorylating conditions. (2011) (74)
- Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain (1994) (70)
- Participation of cytochrome P-450 in the reduction of nitro compounds by rat liver microsomes. (1980) (70)
- Localization of testosterone-sensitive and sexually dimorphic aromatase-immunoreactive cells in the quail preoptic area (1996) (68)
- Aromatase-immunoreactive cells in the quail brain: Effects of testosterone and sex dimorphism (1994) (67)
- Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice (2013) (67)
- Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448. (1984) (66)
- Regulation of Placenta-specific Expression of the Aromatase Cytochrome P-450 Gene (1995) (66)
- A GCM Motif Protein Is Involved in Placenta-specific Expression of Human Aromatase Gene* (1999) (66)
- The Aromatase Knockout (ArKO) Mouse Provides New Evidence That Estrogens Are Required for the Development of the Female Brain (2003) (65)
- Genetic studies to characterize the origin of the mutation in placental aromatase deficiency. (1992) (65)
- Estradiol Promotes Purkinje Dendritic Growth, Spinogenesis, and Synaptogenesis During Neonatal Life by Inducing the Expression of BDNF (2012) (63)
- Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy. (2001) (63)
- Changes in the Arginine‐Vasopressin Immunoreactive Systems in Male Mice Lacking a Functional Aromatase Gene (2002) (63)
- Mouse liver testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha). Purification, regioselectivity, stereospecificity, and sex-dependent expression. (1984) (63)
- Neuroanatomical specificity in the autoregulation of aromatase-immunoreactive neurons by androgens and estrogens: an immunocytochemical study (1992) (62)
- Localization and controls of aromatase in the quail spinal cord (2000) (61)
- Effects of testosterone and its metabolites on aromatase-immunoreactive cells in the quail brain: Relationship with the activation of male reproductive behavior (1996) (60)
- Immunochemical study on the role of different types of microsomal cytochrome P-450 in mutagenesis by chemical carcinogens. (1980) (60)
- Expression of synthetic human-lysozyme gene in Saccharomyces cerevisiae: use of a synthetic chicken-lysozyme signal sequence for secretion and processing. (1986) (60)
- Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. (1999) (58)
- Presence of aromatase and estrogen receptor alpha in the inner ear of zebra finches (2009) (58)
- The Japanese quail: a model for studying reproductive aging of hypothalamic systems (2004) (56)
- Tumor-stromal interaction through the estrogen-signaling pathway in human breast cancer. (2005) (55)
- Distribution and effects of testosterone on aromatase mRNA in the quail forebrain: A non-radioactive in situ hybridization study (1998) (55)
- The Analyses of 17β-Hydroxysteroid Dehydrogenase Isozymes in Human Endometrial Hyperplasia and Carcinoma1 (2001) (54)
- Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice (2005) (53)
- Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status (2003) (53)
- The alternative exons 1 of the mouse aromatase cytochrome P-450 gene. (1996) (53)
- Aromatase in atherosclerotic lesions of human aorta (2001) (52)
- Neuroanatomical Distribution and Variations across the Reproductive Cycle of Aromatase Activity and Aromatase-Immunoreactive Cells in the Pied Flycatcher (Ficedula hypoleuca) (1998) (51)
- Expression and cellular localization of estrogen receptors alpha and beta in the human fetus. (2001) (49)
- Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease? (2008) (49)
- Reciprocal expression of 17alpha-hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis. (2006) (49)
- Distribution of aromatase-immunoreactive cells in the mouse forebrain (2004) (48)
- Mouse liver testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha). Purification, regioselectivity, stereospecificity, and immunochemical characterization. (1984) (48)
- Morphometric studies demonstrate that aromatase-immunoreactive cells are the main target of androgens and estrogens in the quail medial preoptic nucleus (1994) (48)
- Aromatase mRNA Levels in Benign Prostatic Hyperplasia and Prostate Cancer (1996) (48)
- Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity (1995) (48)
- Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain: Double‐label immunocytochemical studies (1998) (47)
- Aromatase and sex steroid receptors in human vena cava. (1999) (46)
- Aromatase inhibitors and enzyme stability. (1999) (45)
- Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer (2003) (44)
- Adrenocortical and gonadal expression of the mammalian Ftz-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control. (1998) (43)
- Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging (1995) (43)
- Analysis of Estrogen Receptor α and β in Endometrial Carcinomas: Correlation with ERβ and Clinicopathologic Findings in 45 Cases (2000) (41)
- Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast (2002) (41)
- 17β-Hydroxysteroid Dehydrogenase Type 1 and 2 Expression in the Human Fetus1 (2000) (39)
- Molecular and epidemiological analyses of abnormal expression of aromatase in breast cancer. (1995) (39)
- Purification and characterization of four forms of cytochrome P-450 from liver microsomes of phenobarbital-treated and 3-methylcholanthrene-treated rats. (1984) (38)
- Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2',5'-tetrachlorobiphenyl in hamster liver. (1995) (37)
- Estrogen secreting adrenal adenocarcinoma in an 18-month-old boy: aromatase activity, protein expression, mRNA and utilization of gonadal type promoter. (2000) (37)
- Sex Differences in Brain Aromatase Activity: Genomic and Non-Genomic Controls (2011) (36)
- The analyses of 17beta-hydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma. (2001) (36)
- Immunoelectron microscopic localization of aromatase in human placenta and ovary using microwave fixation. (1990) (36)
- Aromatase in human common epithelial ovarian neoplasms. (1996) (36)
- Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years. (2006) (36)
- Aromatase cytochrome P450 gene expression in endometrial carcinoma. (1996) (35)
- Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene‐3β, 17β‐diol (2011) (35)
- Forebrain Fos responses to reproductively related chemosensory cues in aromatase knockout mice (2003) (34)
- Effect of Vorozole, an Aromatase Enzyme Inhibitor, on Sexual Behavior, Aromatase Activity and Neural Immunoreactivity (1996) (34)
- Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications. (2005) (34)
- Synergistic control by androgens and estrogens of aromatase in the quail brain. (1994) (34)
- RETRACTED: Neurological effects of aromatase deficiency in the mouse (2003) (34)
- Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice. (2002) (34)
- Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. (1985) (33)
- An association between lipid peroxidation and alpha-naphthylisothiocyanate-induced liver injury in rats. (1999) (33)
- Aromatase- (estrogen synthetase) immunoreactive neurons in the rat septal area. A light and electron microscopic study (1994) (32)
- Pre- and post-translational regulation of aromatase by steroidal and non-steroidal aromatase inhibitors (1995) (32)
- Analysis of estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic findings in 45 cases. (2000) (32)
- Unique regulation of expression of human aromatase in the placenta (2003) (31)
- Protective effect of melatonin against α‐naphthylisothiocyanate‐induced liver injury in rats (2000) (31)
- Immunocytochemical localization of aromatase in sensory and integrating nuclei of the hindbrain in Japanese quail (Coturnix japonica) (2004) (31)
- Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist. (2007) (30)
- Immunochemical study on the participation of cytochrome b5 in drug oxidation reactions of mouse liver microsomes. (1979) (30)
- Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients (2009) (30)
- Targeting steroid receptor coactivator-1 expression with locked nucleic acids antisense reveals different thresholds for the hormonal regulation of male sexual behavior in relation to aromatase activity and protein expression (2006) (30)
- Identification of cis-acting elements in the proximal promoter region for brain-specific exon 1 of the mouse aromatase gene. (1999) (29)
- Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts (2004) (29)
- Change in hepatic antioxidant defense system with liver injury development in rats with a single alpha-naphthylisothiocyanate intoxication. (1999) (29)
- Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes. (1980) (28)
- Correlation of cyclin D1 mRNA levels with clinico‐pathological parameters and clinical outcome in human breast carcinomas (2000) (28)
- Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. (2015) (27)
- Cell type- and region-specific expression of aromatase mRNA in cultured brain cells. (1994) (26)
- Oestrogen receptor‐β1 but not oestrogen receptor‐βcx is of prognostic value in apocrine carcinoma of the breast (2008) (26)
- Effects of changes in gonadal hormones on the amount of aromatase messenger RNA in mouse brain diencephalon. (1993) (26)
- Distribution of aromatase immunoreactivity in the forebrain of red-sided garter snakes at the beginning of the winter dormancy (2002) (25)
- Aromatase and Intracrinology of Estrogen in Hormone-Dependent Tumors (1999) (25)
- Regulation of progestin receptors in medial amygdala: Estradiol, phytoestrogens and sex (2009) (25)
- Porcine Hypothalamic Aromatase Cytochrome P450: Isoform Characterization, Sex-Dependent Activity, Regional Expression, and Regulation by Enzyme Inhibition in Neonatal Boars1 (2009) (25)
- Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues. (2004) (24)
- Expression of synthetic human lysozyme gene in Escherichia coli. (1985) (24)
- Molecular cloning of a cDNA encoding human histidase. (1993) (24)
- 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus. (2000) (24)
- Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells. (1988) (23)
- Activation of peroxisome proliferator-activated receptor-gamma and retinoid X receptor inhibits aromatase transcription via nuclear factor-kappaB. (2005) (23)
- Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver. (1998) (23)
- Relationships Between Aromatase Activity in the Brain and Gonads and Behavioural Deficits in Homozygous and Heterozygous Aromatase Knockout Mice (2004) (23)
- 17β-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract (2001) (22)
- Neurotransmitter‐Mediated Regulation of Brain Aromatase: Protein Kinase C‐ and G‐Dependent Induction (1996) (22)
- Rate-limiting steps in cytochrome P-450-catalysed reactions: studies on isotope effects in the O-de-ethylation of 7-ethoxycoumarin. (1984) (22)
- In vitro increase of aromatase mRNA in diencephalic neurons. (1996) (21)
- Neurological effects of aromatase deficiency in the mouse. (2003) (21)
- Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters. (1985) (21)
- Insulin-like growth factor I enhances the expression of aromatase P450 by inhibiting autophagy. (2010) (20)
- Post‐translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation (2014) (20)
- Inhibitors of aromatase prevent degradation of the enzyme in cultured human tumour cells. (1998) (20)
- Molecular analysis of aberrant expression of aromatase in breast cancer tissues (2004) (20)
- Dietary Isothiocyanates Modify Mitochondrial Functions through Their Electrophilic Reaction (2005) (20)
- From endocrinology to intracrinology (1998) (19)
- Baculovirus mediated high level expression of human placental aromatase (CYP19A1). (1994) (19)
- Genetic susceptibility and environmental estrogen-like compounds. (2001) (19)
- Significance of steroid sulfatase expression in human breast cancer (1999) (19)
- Calcineurin and CRTC2 mediate FSH and TGFβ1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. (2014) (19)
- Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice (2003) (18)
- A calcium-deficient diet caused decreased bone mineral density and secondary elevation of estrogen in aged male rats-effect of menatetrenone and elcatonin. (2002) (17)
- Genetic analysis of human placental aromatase deficiency (1993) (17)
- Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer (2005) (17)
- Expression of oestrogen receptor‐β in apocrine carcinomas of the breast (2007) (17)
- Inhibitory action of Oren-gedoku-to extract on enzymatic lipid peroxidation in rat liver microsomes. (2001) (16)
- Immunohistochemical localization of steroidogenic enzymes in the corpus luteum and the placenta of the ribbon seal (Phoca fasciata) and steller sea lion (Eumetopias jubatus). (2001) (16)
- Expression of estrogen synthetase (P-450 aromatase) during adipose differentiation of 3T3-L1 cells. (1990) (16)
- Expression of aromatase CYP19 and its relationship with parameters in NSCLC. (2009) (15)
- Behavioral Analysis of Genetically Modified Mice Indicates Essential Roles of Neurosteroidal Estrogen (2011) (15)
- [Aromatase deficiency]. (2004) (14)
- HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells (2018) (14)
- Distribution and steroid dependence of aromatase enzyme immunoreactivity in limbic nuclei of the female musk shrew brain (1994) (14)
- Phenobarbital- and 3-methylcholanthrene-induced synthesis of two different molecular species of microsomal cytochrome P-450 in rat liver. (1983) (14)
- Protective Effect of Brazilian Propolis Against Hepatic Oxidative Damage in Rats with Water‐immersion Restraint Stress (2012) (14)
- Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters (1997) (14)
- Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects (2018) (13)
- Aromatase and estrogen receptor beta expression in the rat olfactory bulb: Neuroestrogen action in the first relay station of the olfactory pathway? (2014) (13)
- Intraovarian immunolocalization of steroidogenic enzymes in a Hokkaido brown bear, Ursus arctos yesoensis during the mating season. (1996) (13)
- Specific innervation of aromatase neurons by substance P fibers in the dorsal horn of the spinal cord in quail (2003) (13)
- Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice (2005) (13)
- Aromatase expression in the brain of the ruffed grouse (Bonasa umbellus) and comparisons with other galliform birds (Aves, Galliformes) (2013) (13)
- HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5′ Splice Site (2018) (12)
- Protective Effect of Brazilian Propolis against Liver Damage with Cholestasis in Rats Treated with α-Naphthylisothiocyanate (2013) (12)
- Expression of oestrogen receptor-beta in apocrine carcinomas of the breast. (2007) (12)
- Characterization of testosterone 16 alpha-hydroxylase (I-P-450(16) alpha) induced by phenobarbital in mice. (1985) (12)
- Effects of Organisational Oestradiol on Adult Immunoreactive Oestrogen Receptors (α and β) in the Male Mouse Brain (2007) (12)
- Possible Involvement of Aromatase Overexpression Induced by Cyclo-Oxygenase-2 in the Pathogenesis of Idiopathic Gynecomastia (2005) (12)
- 17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract. (2001) (12)
- Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters. (2015) (12)
- Functional Analysis of Neurosteroidal Oestrogen Using Gene‐Disrupted and Transgenic Mice (2009) (11)
- Ontogeny of Aromatase and Tyrosine Hydroxylase Activity and of Aromatase‐Immunoreactive Cells in the Preoptic Area of Male and Female Japanese Quail (2000) (11)
- Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development (2006) (11)
- Incomplete testicular feminization syndrome: studies on androgen receptor(AR) function, AR gene analysis, and aromatase activities at puberty and long-term observations of clinical and hormonal features from infancy to puberty. (1996) (10)
- Estrogen-Related Factors in the Frontal Lobe of Alzheimer’s Disease Patients and Importance of Body Mass Index (2017) (10)
- Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (alpha and beta) in the male mouse brain. (2007) (9)
- Human Osteoblast-Like Cells Express Aromatase Immunoreactivity (1994) (8)
- LIM‐Homeodomain Transcription Factor, Lhx2, is involved in Transcriptional Control of Brain‐Specific Promoter/Exon 1f of the Mouse Aromatase Gene (2012) (8)
- 1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylpheny)propane inhibits melanin synthesis by dual mechanisms. (2011) (7)
- Expression and transport into mitochondria of bovine cytochrome P-450(SCC) in insect cells using the baculovirus expression system. (1992) (7)
- Immunohistochemical localization of steroidogenic enzymes and prolactin receptors in the corpus luteum and placenta of spotted seals (Phoca largha) during late pregnancy. (2002) (7)
- Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells (2018) (7)
- Identification of a Polymyxin Produced by a Symbiotic Microorganism Isolated from the Brown Planthopper, Nilaparavata lugens (1986) (7)
- Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies (2001) (7)
- The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene (2015) (6)
- Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells. (2017) (6)
- The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin (2008) (6)
- Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation. (1985) (6)
- Localization of estrogen-synthase (aromatase) in the rat spinal cord (2001) (6)
- Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities (2019) (5)
- Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene (2001) (5)
- Mutations in the aromatase gene and their effect. (1992) (5)
- Distribution and sex differences in aromatase-producing neurons in the brain of Japanese quail embryos (2010) (4)
- Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years (2009) (4)
- [The structural and functional characterization of P-450.aromatase (estrogen synthetase)]. (1992) (4)
- [Estrogen synthetase (P-450 . aromatase) as a regulatory factor concerning sexual differentiation of brain and sexual behavior--physiological functions and regulation of gene expression of aromatase]. (1993) (4)
- DISTRIBUTION OF ELECTRON TRANSFER COMPONENTS ON THE SURFACE OF MICROSOMAL MEMBRANE (1980) (3)
- Aromatase expression in the cerebellum of the dog infected with canine distemper virus. (2010) (3)
- Structure, Regulation and Polymorphisms of the Aromatase Gene (2015) (3)
- Molecular cloning of human UMP synthase. (1988) (3)
- Calcineurin and CRTC 2 mediate FSH and TGF b 1 upregulation of Cyp 19 a 1 and Nr 5 a in ovary granulosa cells (2014) (3)
- [A new aspect of the pharmacological and physiological significance of the aromatase/estrogen system]. (1998) (3)
- ARP-1 Regulates the Transcriptional Activity of the Aromatase Gene in the Mouse Brain (2020) (3)
- Inhibition of PP2A in MCF-7 cells leads to hormone-independent growth (2016) (2)
- Upregulation of CIP2A in estrogen depletion‐resistant breast cancer cells treated with low‐dose everolimus (2020) (2)
- Molecular Mechanisms Controlling Brain Aromatase Expression (2012) (2)
- Analysis of Estrogen Receptor &agr; and &bgr; in Endometrial Carcinomas: Correlation with ER&bgr; and Clinicopathologic Findings in 45 Cases (2000) (1)
- [Gene structure and gene expression regulation of estrogen synthetase]. (1989) (1)
- International Congress on Hormonal Steroids and Hormones and Cancer New approaches to the understanding of tamoxifen action and resistance (2003) (1)
- COMPARATIVE BIOCHEMISTRY OF ANIMAL, PLANT, AND MICROORGANISM OXIDASES (1983) (1)
- Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study. (2008) (1)
- Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus. (1999) (1)
- Sex-dependent expression of mouse testosterone 16 a-hydroxylase ( cytochrome P-45016 a ) : cDNA cloning and pretranslational regulation ( sexual dimorphisms / recombinant DNA / hybrid protein ) (1)
- Substrate specificities of cytochrome P-450, C-P-450(16)alpha and P-450(15)alpha, and contribution to steroid hydroxylase activities in mouse liver microsomes. (1988) (1)
- [Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]. (2001) (1)
- Aromatase Controls Sjögren ’ s Syndrome-like Lesions through MCP-1 in Target Organ and Adipose Tissue-Associated Macrophages (2019) (0)
- Recurrence in Human Breast Cancer Steroid Sulfatase Expression Is an Independent Predictor of Updated (1999) (0)
- 2P387 Synthesis of brain steroids and localization of P450s in the hippocampal synapses(44. Neuro-biophysics,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- [Aromatase deficiency]. (2006) (0)
- Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells (2021) (0)
- Activational effects of estradiol on the arginine-vasopressin immunoreactive system in the forebrain of male mice (2004) (0)
- Short Communication Aromatase inHumanCommonEpithelial Ovarian Neoplasms (1996) (0)
- Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of DL-alpha-amino-beta-pyridinepropanoic acid (pyridylalanine) analogs. (1987) (0)
- 17beta-estradiol (E2) abrogated osteolysis induced by HTLV-1 Env protein in vivo (2011) (0)
- Genetic Studies toCharacterize theOrigin oftheMutation in Placental AromataseDeficiency (1992) (0)
- Recent Progress in the Study about Aromatase. (1996) (0)
- EFFECT OF POSTNATAL EXPOSURE OF CIMETIDINE ON BLOOD TESTOSTERONE LEVEL AND HEPATIC MICROSOMAL TESTOSTERONE HYDROXYLATION ACTIVITY IN THE RAT (1984) (0)
- Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters , and switching of tissue-specific exons 1 in carcinogenesis ( alternative splicHng / estrogen synthetase / tissue-specific promoter ) (2005) (0)
- Neurosteroid synthesis and synaptocrinology in the hippocampal synapses (2009) (0)
- Basic Examination of the Developing Mechanism of Atopic Cataract (2002) (0)
- Isolation of a cDNA Clone Encoding Bovine Poly(ADP-Ribose) Synthetase by Immunological Screening of a cDNA Expression Library and its Application as a Probe (1989) (0)
- M089 AN INVESTIGATION OF OBESITY‐RELATED GENE IN AROMATASE KNOCKOUT (ARKO) MICE (2012) (0)
- Structural biology in immunology (PP-041) (2010) (0)
- Endocrine-Related Cancer ( 2003 ) 10 267 – 277 International Congress on Hormonal Steroids and Hormones and Cancer New approaches to the understanding of tamoxifen action and resistance (2003) (0)
- 2P-249 Steroid synthesis and synaptocrinology in the hippocampal synapses(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
- Crucial Involvement of CREB-Regulated Transcription Coactivator (CRTC2) and Calcineurin in FSH and TGFβ1 Upregulation of Cyp19 Expression. (2012) (0)
- 152 MOLECULAR CLONING OF HUMAN UMP SYNTHASE (1988) (0)
- Effects Of Estrogen On The I Kr Channel And Cardiac Repolarization (2009) (0)
- Pathway in Human Breast Cancer Tumor-Stromal Interaction through the Estrogen-Signaling (2005) (0)
- Sexual dimorphism in aromatase-containing neurons in quail embryos (2009) (0)
- Corrigendum to “The Japanese quail: a model for studying reproductive aging of hypothalamic systems” [Experimental Gerontology 39/11–12 (2004) 1679–1693]☆ (2005) (0)
- Abstract 289: Receptor-independent Effects of Estrogen on the HERG Channel Predispose Women to Drug-induced Arrhythmias. (2007) (0)
- Estradiol Promotes Purkinje Dendritic Growth, Spinogenesis, and Synaptogenesis During Neonatal Life by Inducing the Expression of BDNF (2011) (0)
- Expression Levels of Enzymes Related to In Situ Estrogen Synthesis and Clinicopathological Parameters in Breast Cancer Patients. (2009) (0)
- FACTORS INVOLVED IN THE INDUCTION OF THE CYP2B SUBFAMILY P450: SEARCH FOR THE TARGET OF INDUCERS USING PHOTOAFFINITY PROBE AND THE ROLE OF STEROLS IN THE INDUCTION (1999) (0)
- 1P190 The differnces in physiological significance for androgen and estrogen in the rat hippocampus(Neurons and sensory system,Poster Presentations) (2007) (0)
- Expression of Synthetic HumanLysozymeGene in Escherichia coli (2007) (0)
- 3P252 Is there sex difference in the hippocampus, the center of learning and memory? Part2(Neuroscience & Sensory systems,The 48th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- Sex hormone synthesis and synaptocrinology in the hippocampal synapses of adult male rats (2010) (0)
- [The molecular mechanism of IL-4]. (1991) (0)
- The fast regulation of aromatase activity by phosphorylations is species and tissue-independent. (2009) (0)
- Species and tissue-independent rapid regulation of aromatase activity by phosphorylations. (2009) (0)
- Regulatory mechanism of tissue-specific expression of aromatase (estrogen synthetase) and its physiological significance (1998) (0)
- ANALYSIS OF THE ROLE OF ESTROGEN IN THE GROWTH OF CEREBELLAR PURKINJE CELLS USING AROMATASE-DEFICIENT MICE (2003) (0)
- Retraction notice to “Neurological effects of aromatase deficiency in the mouse” [J. Steroid Biochem. Mol. Biol. 86 (2003) 357–365] (2012) (0)
- COMPARATIVE ENDOCRINOLOGY OF THE GENETIC REGULATION SYSTEMS AND THE PHYSIOLOGICAL FUNCTIONS OF ESTROGEN SYNTHETASE (AROMATASE) (1999) (0)
- Sex hormone synthesis and synaptocrinology in rat hippocampal synapses (2011) (0)
- Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice (2012) (0)
- Estrogen-Related Factors in the Frontal Lobe of Alzheimer’s Disease Patients and Importance of Body Mass Index (2017) (0)
- Steroid synthesis and synaptocrinology in the hippocampal synapses (2007) (0)
- Steroid hormone action and sex differences in brain function (2011) (0)
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What Schools Are Affiliated With Nobuhiro Harada?
Nobuhiro Harada is affiliated with the following schools:
