Norbert Perrimon
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#2093
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#633
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#149
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Biology
Norbert Perrimon's Degrees
- PhD Genetics Université Paris Cité
- Bachelors Biochemistry Université Paris Cité
Why Is Norbert Perrimon Influential?
(Suggest an Edit or Addition)According to Wikipedia, Norbert Perrimon is a French geneticist and developmental biologist. He is the James Stillman Professor of Developmental Biology in the Department of Genetics at Harvard Medical School, an Investigator at the Howard Hughes Medical Institute, and an Associate of the Broad Institute. He is known for developing a number of techniques for used in genetic research with Drosophila melanogaster, as well as specific substantive contributions to signal transduction, developmental biology and physiology.
Norbert Perrimon's Published Works
Published Works
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. (1993) (9420)
- Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE (2010) (1211)
- Highly-efficient Cas9-mediated transcriptional programming (2014) (1084)
- Evidence that stem cells reside in the adult Drosophila midgut epithelium (2006) (988)
- Droplet microfluidic technology for single-cell high-throughput screening (2009) (977)
- Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. (2000) (922)
- The Promise and Perils of Wnt Signaling Through β-Catenin (2002) (919)
- The Developmental Transcriptome of Drosophila melanogaster (2010) (766)
- Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells (2004) (762)
- A genome-scale shRNA resource for transgenic RNAi in Drosophila (2011) (728)
- Specificities of heparan sulphate proteoglycans in developmental processes (2000) (722)
- Efficient proximity labeling in living cells and organisms with TurboID (2018) (710)
- Localization of apical epithelial determinants by the basolateral PDZ protein Scribble (2000) (705)
- An endogenous small interfering RNA pathway in Drosophila (2008) (693)
- The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. (1996) (687)
- Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. (1998) (659)
- Developmental cell biology: Heparan sulphate proteoglycans: the sweet side of development (2005) (648)
- Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo (2009) (622)
- Diversity and dynamics of the Drosophila transcriptome (2014) (558)
- FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging (2010) (554)
- Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion (1998) (538)
- An integrative approach to ortholog prediction for disease-focused and other functional studies (2011) (525)
- Sequential activation of signaling pathways during innate immune responses in Drosophila. (2002) (519)
- Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila. (1992) (512)
- Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. (1995) (493)
- Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes (2008) (489)
- Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling (1999) (477)
- A functional genomic analysis of cell morphology using RNA interference (2003) (464)
- The promise and perils of Wnt signaling through beta-catenin. (2002) (461)
- Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. (2003) (456)
- Minimizing the risk of reporting false positives in large-scale RNAi screens (2006) (454)
- Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled (1996) (448)
- Integrated activity of PDZ protein complexes regulates epithelial polarity (2003) (442)
- wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate (1992) (417)
- The Transgenic RNAi Project at Harvard Medical School: Resources and Validation (2015) (411)
- The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. (1994) (409)
- The emergence of geometric order in proliferating metazoan epithelia (2006) (404)
- dishevelled and armadillo act in the Wingless signalling pathway in Drosophila (1994) (394)
- High-throughput RNAi screening in cultured cells: a user's guide (2006) (392)
- Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. (1999) (388)
- Drosophila RNAi Screen Reveals CD36 Family Member Required for Mycobacterial Infection (2005) (381)
- marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs (1996) (378)
- Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. (1999) (372)
- corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso (1992) (366)
- Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. (2001) (363)
- Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. (1998) (359)
- Drosophila Cytokine Unpaired 2 Regulates Physiological Homeostasis by Remotely Controlling Insulin Secretion (2012) (358)
- Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9 (2013) (357)
- The roles of JAK/STAT signaling in Drosophila immune responses (2004) (347)
- The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. (1996) (341)
- Functional genomics reveals genes involved in protein secretion and Golgi organization (2006) (337)
- Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway (2005) (337)
- GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. (2007) (336)
- Components of wingless signalling in Drosophila (1994) (334)
- The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. (1990) (334)
- Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets (2004) (330)
- A Drosophila Resource of Transgenic RNAi Lines for Neurogenetics (2009) (324)
- Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. (1994) (319)
- Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology (2007) (319)
- DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. (1998) (319)
- Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. (1993) (317)
- Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling (2013) (317)
- Signaling mechanisms controlling cell fate and embryonic patterning. (2012) (307)
- Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster (2008) (305)
- Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection (2005) (299)
- RNAi screening comes of age: improved techniques and complementary approaches (2014) (293)
- Genomic screening with RNAi: results and challenges. (2010) (290)
- The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. (1997) (290)
- The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. (1992) (286)
- Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays (2006) (281)
- The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development (1990) (276)
- Hierarchical rules for Argonaute loading in Drosophila. (2009) (269)
- Comparative Analysis of the Transcriptome across Distant Species (2014) (268)
- FlyBase: updates to the Drosophila melanogaster knowledge base (2020) (266)
- Molecular mechanisms of epithelial morphogenesis. (2002) (263)
- Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. (2015) (262)
- Seipin is required for converting nascent to mature lipid droplets (2016) (261)
- Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. (1993) (254)
- Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts (2001) (252)
- The PDGF/VEGF receptor controls blood cell survival in Drosophila. (2004) (247)
- Comparative Analysis of Cas9 Activators Across Multiple Species (2016) (247)
- The Jak/STAT pathway in model organisms: emerging roles in cell movement. (2002) (243)
- The transcriptional diversity of 25 Drosophila cell lines. (2011) (241)
- Safeguarding gene drive experiments in the laboratory (2015) (234)
- Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. (2011) (232)
- Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. (2005) (231)
- A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling (2006) (228)
- The Transmembrane Molecule Kekkon 1 Acts in a Feedback Loop to Negatively Regulate the Activity of the Drosophila EGF Receptor during Oogenesis (1999) (225)
- Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. (2005) (223)
- Multiple functions of segment polarity genes in Drosophila. (1987) (221)
- Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome. (1989) (216)
- Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity (2005) (213)
- Identifying loci required for follicular patterning using directed mosaics. (1998) (213)
- Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models (2013) (207)
- Altering the insertional specificity of a Drosophila transposable element. (1992) (206)
- Activation of posterior gap gene expression in the Drosophila blastoderm (1995) (204)
- Ectopic expression in Drosophila. (1994) (203)
- Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets (2015) (201)
- The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz (1997) (196)
- Synergy between bacterial infection and genetic predisposition in intestinal dysplasia (2009) (195)
- In vivo RNAi: today and tomorrow. (2010) (194)
- Frizzled signaling and the developmental control of cell polarity. (1998) (194)
- Hedgehog signal transduction: recent findings. (2002) (193)
- Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. (1994) (193)
- A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway (2005) (192)
- Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. (1996) (190)
- Extrusion and Death of DPP/BMP-Compromised Epithelial Cells in the Developing Drosophila Wing (2005) (190)
- Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. (1994) (186)
- Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. (2012) (185)
- Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. (1997) (183)
- Dual functions of wingless in the Drosophila leg imaginal disc. (1995) (183)
- Temperature-sensitive control of protein activity by conditionally splicing inteins (2004) (183)
- The genetic basis of patterned baldness in Drosophila (1994) (182)
- Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2. (2015) (180)
- Drosophila and the genetics of the internal milieu (2007) (178)
- Control of the Mitotic Cleavage Plane by Local Epithelial Topology (2011) (177)
- neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions (2003) (174)
- X-linked female-sterile loci in Drosophila melanogaster. (1986) (173)
- Genetic Screening for Signal Transduction in the Era of Network Biology (2007) (171)
- Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel (2018) (169)
- Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. (1995) (169)
- A Screen for Morphological Complexity Identifies Regulators of Switch-like Transitions between Discrete Cell Shapes (2013) (167)
- Drosophila wingless: A paradigm for the function and mechanism of Wnt signaling (1994) (166)
- The influence of skeletal muscle on systemic aging and lifespan (2013) (165)
- Requirement of the Drosophila raf homologue for torso function (1989) (165)
- The roles of the Drosophila JAK/STAT pathway (2000) (164)
- The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration (2010) (164)
- The ovo locus is required for sex-specific germ line maintenance in Drosophila. (1987) (163)
- Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila (2009) (162)
- The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration (2010) (161)
- Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. (1999) (159)
- γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila (2003) (156)
- Simple and efficient generation of marked clones in Drosophila (1993) (154)
- Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3′UTRs (2010) (153)
- A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster. (1997) (153)
- Hedgehog and beyond (1995) (153)
- The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification (1999) (151)
- Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3 (1990) (149)
- MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. (2017) (148)
- Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. (2002) (148)
- Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. (2002) (147)
- Recruitment of Scribble to the Synaptic Scaffolding Complex Requires GUK-holder, a Novel DLG Binding Protein (2002) (145)
- A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila (2010) (144)
- A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. (2003) (144)
- The Hippo Signaling Pathway Interactome (2013) (142)
- Control of lipid metabolism by tachykinin in Drosophila. (2014) (141)
- The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis. (1996) (140)
- Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. (2012) (140)
- Interorgan Communication Pathways in Physiology: Focus on Drosophila. (2016) (138)
- Apicobasal polarization: epithelial form and function. (2003) (136)
- Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. (2011) (136)
- Multiple roles for four-jointed in planar polarity and limb patterning. (2000) (136)
- Loss-of-function genetic tools for animal models: cross-species and cross-platform differences (2016) (136)
- RNAi screening: new approaches, understandings, and organisms (2012) (136)
- There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor (1997) (135)
- Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. (2008) (135)
- Negative Feedback Mechanisms and Their Roles during Pattern Formation (1999) (135)
- Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis (2004) (135)
- Spatial control of the actin cytoskeleton in Drosophila epithelial cells (2001) (135)
- Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis. (1997) (135)
- Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. (1983) (135)
- Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. (2014) (135)
- COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication (2006) (133)
- Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. (2003) (132)
- Phosphorylation Networks Regulating JNK Activity in Diverse Genetic Backgrounds (2008) (132)
- The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. (2000) (129)
- Integrating protein-protein interaction networks with phenotypes reveals signs of interactions (2013) (126)
- A gene-specific T2A-GAL4 library for Drosophila (2018) (126)
- Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. (2013) (125)
- Cellular functions of proteoglycans--an overview. (2001) (124)
- FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents (2013) (123)
- Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases (2014) (122)
- Design and implementation of high-throughput RNAi screens in cultured Drosophila cells (2007) (121)
- The torso receptor tyrosine kinase can activate raf in a ras-independent pathway (1995) (121)
- Stress signaling in Drosophila (1999) (120)
- A regulatory network of Drosophila germline stem cell self-renewal. (2014) (120)
- A cell atlas of the adult Drosophila midgut (2018) (120)
- Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. (2002) (118)
- The molecular genetics of head development in Drosophila melanogaster. (1991) (117)
- Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (2015) (116)
- The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. (1994) (116)
- The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. (1996) (116)
- l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. (1986) (116)
- Developmental genetics of the 2C-D region of the Drosophila X chromosome. (1985) (115)
- The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. (1996) (115)
- Mechanisms of muscle growth and atrophy in mammals and Drosophila (2014) (115)
- The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. (2004) (115)
- Alliance of Genome Resources Portal: unified model organism research platform (2019) (113)
- Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. (1994) (113)
- Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2 (1996) (112)
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi (2015) (112)
- Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events (2001) (112)
- Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila. (2014) (112)
- Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase (2015) (111)
- A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist (1995) (111)
- Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly (2022) (111)
- Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. (1993) (110)
- Applications of High-Throughput RNA Interference Screens to Problems in Cell and Developmental Biology (2007) (110)
- Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. (2000) (110)
- In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography (2007) (107)
- Generating lineage-specific markers to study Drosophila development. (1991) (107)
- Genetic evidence that the sans fille locus is involved in Drosophila sex determination. (1988) (107)
- The effects of zygotic lethal mutations on female germ-line functions in Drosophila. (1984) (106)
- The torso receptor protein-tyrosine kinase signaling pathway: An endless story (1993) (106)
- The Circadian Clock Gates the Intestinal Stem Cell Regenerative State (2013) (105)
- In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila (2015) (105)
- Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. (1993) (104)
- Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species (2019) (103)
- Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. (2009) (103)
- A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast (2000) (102)
- Role of heparan sulfate proteoglycans in cell-cell signaling in Drosophila. (2000) (102)
- wingless refines its own expression domain on the Drosophila wing margin (1996) (101)
- Identification of Neural Outgrowth Genes using Genome-Wide RNAi (2008) (101)
- Autosomal P [ ovo D 1 ] dominant female-sterile insertions in Drosophila and their use in generating germline chimeras (1996) (101)
- Analysis of twenty‐four Gal4 lines in Drosophila melanogaster (2002) (100)
- A Drosophila Homolog of Cyclase-Associated Proteins Collaborates with the Abl Tyrosine Kinase to Control Midline Axon Pathfinding (2002) (100)
- Systematic screen of chemotherapeutics in Drosophila stem cell tumors (2014) (100)
- Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. (1998) (99)
- mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. (2017) (98)
- Intertissue control of the nucleolus via a myokine-dependent longevity pathway. (2014) (97)
- Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling (2011) (97)
- BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. (2005) (95)
- Depleting Gene Activities in Early Drosophila Embryos with the “Maternal-Gal4–shRNA” System (2013) (94)
- Protein Complex–Based Analysis Framework for High-Throughput Data Sets (2013) (92)
- Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy (2013) (91)
- A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. (1999) (91)
- Evidence for engrailed-independent wingless autoregulation in Drosophila. (1995) (91)
- A genome-wide transgenic resource for conditional expression of Drosophila microRNAs (2012) (90)
- High-throughput RNA interference screens in Drosophila tissue culture cells. (2005) (90)
- The maternal effect of lethal(1)discs-large-1: a recessive oncogene of Drosophila melanogaster. (1988) (89)
- FlyRNAi: the Drosophila RNAi screening center database (2005) (88)
- Stringent Analysis of Gene Function and Protein–Protein Interactions Using Fluorescently Tagged Genes (2012) (87)
- Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model (2009) (86)
- The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila (2003) (85)
- Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. (2015) (85)
- Functional screening identifies miR-315 as a potent activator of Wingless signaling (2007) (84)
- Of flies and men: insights on organismal metabolism from fruit flies (2013) (84)
- Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. (2002) (84)
- Collective nomenclature for LAP proteins (2000) (82)
- Tailoring the genome: the power of genetic approaches (2003) (81)
- Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control. (2017) (81)
- ESCRT factors restrict mycobacterial growth (2008) (80)
- slalom encodes an adenosine 3′‐phosphate 5′‐phosphosulfate transporter essential for development in Drosophila (2003) (80)
- A single-cell survey of Drosophila blood (2019) (80)
- A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila. (2018) (78)
- The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. (1989) (78)
- Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes (2010) (77)
- Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel (2018) (76)
- Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis. (2011) (75)
- Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster (1990) (75)
- CKA, a Novel Multidomain Protein, Regulates the JUN N-Terminal Kinase Signal Transduction Pathway in Drosophila (2002) (74)
- A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster. (1985) (74)
- Serpentine Proteins Slither into the Wingless and Hedgehog Fields (1996) (74)
- Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. (1989) (73)
- A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression (2007) (73)
- Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex (2018) (73)
- RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance (2008) (73)
- Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1 (2003) (72)
- Cellular Phenotype Recognition for High-Content RNA Interference Genome-Wide Screening (2008) (72)
- polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila. (1988) (72)
- orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. (1992) (72)
- Retraction of the Drosophila germ band requires cell-matrix interaction. (2003) (71)
- Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut (2017) (70)
- Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling (2010) (69)
- Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses (2013) (69)
- I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila. (1999) (68)
- Roles of myosin phosphatase during Drosophila development (2003) (68)
- An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms (2019) (68)
- Developmental roles of heparan sulfate proteoglycans in Drosophila (2002) (67)
- SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. (2007) (67)
- Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. (1986) (67)
- Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype (2011) (67)
- Cellular processes associated with germ band retraction in Drosophila. (2002) (67)
- Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER. (1984) (66)
- Resources for Functional Genomics Studies in Drosophila melanogaster (2014) (66)
- The JAK-STAT pathway in Drosophila. (1997) (66)
- The Twin Spot Generator for differential Drosophila lineage analysis (2009) (66)
- FlyBase: a guided tour of highlighted features (2022) (65)
- Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry (2013) (65)
- Drosophila melanogaster homologs of the raf oncogene (1987) (65)
- Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila (2020) (65)
- CRISPR guide RNA design for research applications (2016) (65)
- Receptor tyrosine kinases in Drosophila development. (2013) (64)
- The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. (1997) (63)
- Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes (2018) (62)
- An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. (2016) (62)
- A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. (1994) (61)
- The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. (2002) (61)
- The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway. (2001) (61)
- Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila (2016) (60)
- Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes. (1984) (60)
- Use of a yeast site-specific recombinase to generate embryonic mosaics in Drosophila. (1992) (60)
- Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens (2008) (59)
- Drosophila as a Model for Context‐Dependent Tumorigenesis (2013) (59)
- Genome-wide high-throughput screens in functional genomics. (2004) (58)
- The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. (2001) (58)
- Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. (2014) (58)
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- Mammalian and Drosophila Blood : Minireview JAK of All Trades ? essential (1998) (0)
- Signaling in time and space (2014) (0)
- A Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors (2020) (0)
- Similar phenotypic profiles identified genes in pathways and protein complexes (2011) (0)
- Diversity and dynamics of the Drosophila transcriptome Please share how this access benefits you. Your story matters (2014) (0)
- A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stress (2021) (0)
- Enabling IMaC purification of low abundance recombinant proteins from E . coli lysates (2009) (0)
- Toward a Systems Understanding of Signaling Pathway Function. (2016) (0)
- Chapter 8 – Functional Genomics Screens in Drosophila Cells (2018) (0)
- Cells by Soaking with dsRNA Drosophila Inducing RNAi in (2014) (0)
- Title: TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data (2020) (0)
- Roles of Insect Oenocytes in Physiology and Their Relevance to Human Metabolic Diseases (2022) (0)
- The Segment Polarity Gene porcupine Encodes an Evolutionary Conserved Transmembrane Protein Acting Non-autonomously in the Wingless Signaling Pathway (1996) (0)
- Faculty Opinions recommendation of Dynamics of Dpp signaling and proliferation control. (2011) (0)
- REPTOR/CREBRF encode key regulators of muscle energy metabolism (2021) (0)
- Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis (2014) (0)
- No sugar, just protein please — says the fly (2022) (0)
- Erratum: Integrating protein-protein interaction networks with phenotypes reveals signs of interactions (2014) (0)
- Faculty Opinions recommendation of Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. (2004) (0)
- pathways specificity in the planar cell polarity and Wingless signaling Differential recruitment of Dishevelled provides signaling (1998) (0)
- Liz and Norbert at the movies (2003) (0)
- Resource An Integrative Analysis of the InR / PI 3 K / Akt Network Identifies the Dynamic Response to Insulin Signaling Graphical (0)
- Inter-Organ Communication Network (2017) (0)
- Midgut-Derived Activin Re gulates Glucagon-like Action in the Fat Body and Glycemic Control Graphical Abstract Highlights (0)
- DmRaf: Raf homologue (D. melanogaster) (1995) (0)
- Faculty Opinions recommendation of Systems survey of endocytosis by multiparametric image analysis. (2010) (0)
- Ras to Extracellular Signal-Regulated Kinase Signaling Proteomic and Functional Genomic Landscape of Receptor Tyrosine (2011) (0)
- CHAPTER 251 – Developmental Signaling: JNK Pathway in Drosophila Morphogenesis (2003) (0)
- Key Experiments in Practical Developmental Biology: The UAS/GAL4 system for tissue-specific analysis of EGFR gene function in Drosophila melanogaster (2005) (0)
- Supplemental Data Document S 1 . Supplemental Experimental Procedures and Three Figures ( see next (2016) (0)
- Open questions: completing the parts list and finding the integrating signals (2017) (0)
- Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions (2017) (0)
- Faculty Opinions recommendation of A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. (2008) (0)
- Wiring and Rewiring in Signal Transduction Spatial and temporal organization of signaling pathways (2014) (0)
- The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions (2019) (0)
- Interorgan crosstalk and metabolism regulation in Drosophila (2022) (0)
- Correction: Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue (2021) (0)
- A test of RNAi screen efficacy: identifying genes involved in cell-cycle progression (2011) (0)
- Faculty Opinions recommendation of Planar polarity and actin dynamics in the epidermis of Drosophila. (2002) (0)
- Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling (2016) (0)
- Connecting up the pathways in Drosophila development. (1997) (0)
- Faculty Opinions recommendation of Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. (2006) (0)
- Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue. (2020) (0)
- Stable Force Balance betweenEpithelial Cells Arises from F-Actin Turnover Graphical Abstract Highlights (2015) (0)
- Unbiased Combinatorial Genomic Approaches to Identify Alternative Therapeutic Targets within the TSC Signaling Network (2014) (0)
- Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila (2022) (0)
- morphological data from a combinatorial RNAi screen Inference of RhoGAP / GTPase regulation using single-cell Material (2010) (0)
- New Sodern's APS Based Autonomous Multiple Heads Star Sensor (hydra): Three Heads are Better than One (2006) (0)
- Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome (2023) (0)
- Science Signaling Podcast: 25 October 2011 (2011) (0)
- The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos (2015) (0)
- A membrane transporter is required for steroid hormone uptake in Drosophila (2019) (0)
- NanoTag Nanobody Tools for Drosophila In Vitro and In Vivo Studies (2022) (0)
- Regulation of ErbB Receptor Tyrosine Kinase Activities in Breast Cancer by the Kek Proteins (1999) (0)
- Airway RemodelingDrosophilaGrowth During The Homeobox Transcription Factor Cut Coordinates Patterning and ` (2013) (0)
- Faculty Opinions recommendation of Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. (2005) (0)
- The Twin Spot Generator technique for differential labeling of daughter cell lineages in Drosophila (2008) (0)
- cell lines Drosophila The transcriptional diversity of 25 Material Supplemental (2010) (0)
- Faculty of 1000 evaluation for Guidance of cell migration by the Drosophila PDGF/VEGF receptor. (2012) (0)
- Expanding the horizons of genome editing in the fruit fly with Cas12a (2020) (0)
- CRISPR-Based Perturbation of Gene Function in Drosophila Cells (2018) (0)
- The activity of smooth muscle/non-muscle myosin II is regulated by the phosphorylation of MRLC that is modulated by the antagonistic activity of myosin light chain kinase (MLCK) and myosin light chain phosphatase (MLCP). MLCP (2002) (0)
- Supplemental Information A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal (2014) (0)
- Chromosome of Drosophila melanogaster (2002) (0)
- A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues. (2010) (0)
- Development of CRISPR knockout screening in mosquito cell lines (2020) (0)
- Abstract IA4: Synthetic lethal screens in Drosophila (2013) (0)
- An Instrumental and Software Platform for The Targeted Protein-Protein Interact-ome of Signaling Pathways from Drosophila to Human Cancer Cells (2010) (0)
- The TORC 1-Regulated CP A Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming Graphical (0)
- Live-cell imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography (2007) (0)
- A genetic dissection of cell morphogenesis in Drosophila (2004) (0)
- A sharp end to sugary Wingless travels (2014) (0)
- Conserved phosphorylation hotspots in eukaryotic protein domain families (2019) (0)
- Levels of gene expression do not necessarily correlate with gene function (2011) (0)
- RNAi profiles identify known and novel genes with related morphogenetic functions (2011) (0)
- Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy Under Nutrient Stress via Drosophila Upd2 Repression (2020) (0)
- Meeting Review Formation and Remodeling of Epithelial Polarity (2004) (0)
- 3494 Two RTK pathways , the Platelet-Derived Growth Factor / Vascular Endothelial Growth (2005) (0)
- Editorial board members (2007) (0)
- Faculty Opinions recommendation of Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003) (0)
- regions of mammalian mRNAs Unusually effective microRNA targeting within repeat-rich coding Material Supplemental (2011) (0)
- Prioritizing transcription factor perturbations from single-cell transcriptomics (2023) (0)
- Author Correction: Efficient proximity labeling in living cells and organisms with TurboID (2019) (0)
- The mammalian epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases (2001) (0)
- Analyses Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic ` (2013) (0)
- Developmental Cell PaperPick Deciphering Gene Expression Patterns (2011) (0)
- Supporting Online Material for Local Signaling Networks That Regulate Cell Morphology Defined by Quantitative Morphological Signatures (2007) (0)
- Abstract IA11: Combinatorial screens in Drosophila cells (2017) (0)
- Inferring genetic architecture from systems genetics studies (2015) (0)
- Sets Protein Complex-Based Analysis Framework for High-Throughput Data ` (2013) (0)
- Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies (2011) (0)
- Glycosylation and Notch signaling (2001) (0)
- Faculty Opinions recommendation of Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. (2003) (0)
- Modeling exercise using optogenetically contractible Drosophila larvae (2022) (0)
- One-eyed pinhead dependent cell motility in the zebrafish blastula (2000) (0)
- Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research (2023) (0)
- Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila (2020) (0)
- A role for actomyosin contractility in Notch signaling (2019) (0)
- 7 PRIME TIME FOR THE DROSOPHILA JAK / STAT PATHWAY (2004) (0)
- Drosophila.ovo locus is required for sex-specific germ line maintenance in (2010) (0)
- PANGEA: A New Gene Set Enrichment Tool for Drosophila and Common Research Organisms (2023) (0)
- Optimal transport analysis of single-cell transcriptomics directs hypotheses 1 prioritization and validation (2022) (0)
- Damage Checkpoint-M DNA 2 A Genome-Wide RNAi Screen Identifies Core Components of the G (2010) (0)
- 8 Inferring Genetic Architecture from Systems Genetics Studies (2014) (0)
- 1-1 Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington ’ s disease model (2010) (0)
- Perrimon tyrosine kinases . conservation of the signaling pathways activated by receptor A temperature-sensitive MEK mutation demonstrates the (2007) (0)
- Faculty Opinions recommendation of Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway. (2006) (0)
- Author Reagent Table: a proposal (2017) (0)
- Molecular and functional characterization of the Drosophila melanogaster conserved smORFome (2022) (0)
- The Drosophila EGF receptor (DER) belongs to a large family of transmembrane receptors with intrinsic kinase activity known as receptor tyrosine kinases (RTKs). Following ligand (1999) (0)
- SEGMENTATIONOFDROSOPHILARNAIFLUORESCENCEIMAGES USINGLEVEL SETS (2006) (0)
- RNAi screens identified a wide range of gene functions based on diverse morphological phenotypes (2011) (0)
- Studies of the PS-1 pedigree from Columbia (2000) (0)
- Faculty Opinions recommendation of Regulation of Lethal giant larvae by Dishevelled. (2005) (0)
- Gene knock-ins in Drosophila using homology-independent insertion of universal 1 donor plasmids 2 3 (2019) (0)
- Trans-omic Analysis of Insulin Action Reveals a Sub-Network Required for Cell Growth Through Co-Regulated Gene Expression of Anabolic Processes (2022) (0)
- Hedgehog and Heparan Sulfate Proteoglycans (2004) (0)
- Faculty Opinions recommendation of Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. (2005) (0)
- Body composition and lung cancer-associated cachexia in TRACERx (2023) (0)
- Author Correction: Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos (2022) (0)
- Prime Editing for Precise Genome Engineering in Drosophila. (2022) (0)
- ARY functions of wingless in the Drosophila leg imag (1995) (0)
- Faculty Opinions recommendation of Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. (2004) (0)
- Deciphering Gene Expression Patterns (2011) (0)
- Parallel Genomic and Chemical Screens to Identify Both Therapeutic Targets and Inhibitors of These Targets in the Treatment of Neurofibromatosis (2006) (0)
- Synthetic Notch receptors and their applications to study cell-cell contacts in vivo. (2023) (0)
- The Septate Junction Prot ein Tsp 2 A Restricts Intestinal StemCell Activity via Endocytic Regulation of aPKC and Hippo Signaling Graphical (2019) (0)
- N Perrimon dorsoventral polarity during Drosophila oogenesis . Raf acts downstream of the EGF receptor to determine (2007) (0)
- Developmental Cell Previews The Multidimensional Organization of Interorgan Communication Networks (0)
- factor involved in dorsal-ventral axis formation and neurogenesis . The Drosophila spitz gene encodes a putative EGF-like growth (2007) (0)
- A phosphate-sensing organelle regulates phosphate and tissue homeostasis. (2023) (0)
- N Perrimon dorsoventral polarity during Drosophila oogenesis . Raf acts downstream of the EGF receptor to determine (2007) (0)
- Developmental Cell Resource A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal (0)
- Introduction to the Second Edition (2018) (0)
- RNA interference : Mechanisms and Applications (2006) (0)
- split-intein Gal4 provides intersectional genetic labeling that is fully repressible by Gal80 (2023) (0)
- Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells (2022) (0)
- 54 th Annual Drosophila Research Conference Late Abstracts (2013) (0)
- Long-range Notch-mediated tissue patterning requires actomyosin contractility (2018) (0)
- Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling (2022) (0)
- Cachexia: A systemic consequence of progressive, unresolved disease (2023) (0)
- Synthetic lethal screening identifies existing autophagy drugs with selective viability effects on Neurofibromatosis type-1 model systems (2021) (0)
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