Norma Andrews
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American cell biologist and Professor at the University of Maryland Department of Cell Biology and Molecular Genetics
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Norma Andrewsbiology Degrees
Biology
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Cell Biology
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#478
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#69
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Molecular Biology
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#2437
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#244
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Biology
Why Is Norma Andrews Influential?
(Suggest an Edit or Addition)According to Wikipedia, Norma W. Andrews is a cell biologist and professor at the University of Maryland Department of Cell Biology and Molecular Genetics. She chaired the department from 2009 to 2014. Education and career Norma Andrews received her B.S. in 1977 and Ph.D. in 1983, both from the University of São Paulo. She then went on to a postdoctoral fellowship in the laboratory of Victor Nussenzweig at New York University, which she completed in 1990. She then began her own laboratory at Yale University, where she joined the Department of Cell Biology and the Section of Microbial Pathogenesis becoming a Full Professor in 1999. In 2009, Andrews moved her lab to the University of Maryland to chair the Department of Cell Biology and Molecular Genetics. She stepped down from that position in 2014.
Norma Andrews's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Plasma Membrane Repair Is Mediated by Ca2+-Regulated Exocytosis of Lysosomes (2001) (930)
- Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells (1997) (526)
- Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells (1992) (398)
- Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis (2008) (391)
- Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells (2002) (361)
- Regulated secretion of conventional lysosomes. (2000) (348)
- Synaptotagmin VII Regulates Ca2+-Dependent Exocytosis of Lysosomes in Fibroblasts (2000) (315)
- Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis* (2004) (308)
- Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair (2010) (303)
- Damage control: cellular mechanisms of plasma membrane repair. (2014) (236)
- The Trypanosoma cruzi–host-cell interplay: location, invasion, retention (2005) (226)
- Stage-specific surface antigens expressed during the morphogenesis of vertebrate forms of Trypanosoma cruzi. (1987) (224)
- The mechanisms of Trypanosoma cruzi invasion of mammalian cells. (1995) (223)
- A T. cruzi-secreted protein immunologically related to the complement component C9: Evidence for membrane pore-forming activity at low pH (1990) (208)
- Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients (1994) (207)
- Oligopeptidase B‐dependent signaling mediates host cell invasion by Trypanosoma cruzi (1998) (200)
- Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice (2003) (200)
- The exit of Trypanosoma cruzi from the phagosome is inhibited by raising the pH of acidic compartments (1990) (184)
- A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells (1995) (184)
- Adhesion and interiorization of Trypanosoma cruzi in mammalian cells. (1982) (183)
- A Cytosolic Serine Endopeptidase from Trypanosoma cruzi Is Required for the Generation of Ca2+ Signaling in Mammalian Cells (1997) (168)
- Host cell invasion by trypanosomes requires lysosomes and microtubule/kinesin-mediated transport (1996) (165)
- Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. (1993) (158)
- A Role for Synaptotagmin VII-Regulated Exocytosis of Lysosomes in Neurite Outgrowth from Primary Sympathetic Neurons (2006) (158)
- Ca2+ and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes (2006) (148)
- Two-way traffic on the road to plasma membrane repair. (2008) (143)
- A Process for Controlling Intracellular Bacterial Infections Induced by Membrane Injury (2004) (142)
- A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes (2006) (142)
- Amastigotes of Trypanosoma cruzi sustain an infective cycle in mammalian cells (1988) (140)
- cAMP Regulates Ca2+-dependent Exocytosis of Lysosomes and Lysosome-mediated Cell Invasion by Trypanosomes* (1999) (139)
- Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells. (2004) (138)
- Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm (1992) (132)
- Lysosomal Fusion Is Essential for the Retention of Trypanosoma cruzi Inside Host Cells (2004) (129)
- Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion (2011) (126)
- Caveolae internalization repairs wounded cells and muscle fibers (2013) (124)
- Signaling and host cell invasion by Trypanosoma cruzi. (1998) (117)
- Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein (1986) (116)
- A 120-kDa Alkaline Peptidase from Trypanosoma cruzi Is Involved in the Generation of a Novel Ca2+-signaling Factor for Mammalian Cells (*) (1995) (116)
- Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. (2008) (115)
- Plasma membrane repair (2018) (114)
- Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels (2013) (110)
- Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence. (2012) (105)
- Synaptotagmin VII Restricts Fusion Pore Expansion during Lysosomal Exocytosis (2004) (104)
- Developmentally regulated, phospholipase C-mediated release of the major surface glycoprotein of amastigotes of Trypanosoma cruzi (1988) (95)
- Secretion by Trypanosoma cruzi of a hemolysin active at low pH. (1989) (95)
- Synaptotagmin-mediated vesicle fusion regulates cell migration (2010) (95)
- Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1 (2012) (87)
- Toxin Pores Endocytosed During Plasma Membrane Repair Traffic into the Lumen of MVBs for Degradation (2012) (87)
- Iron acquisition within host cells and the pathogenicity of Leishmania (2007) (84)
- There's more to life than neurotransmission: the regulation of exocytosis by synaptotagmin VII. (2005) (83)
- Cell surface antigens of Trypanosoma cruzi: possible correlation with the interiorization process in mammalian cells. (1982) (82)
- Oligopeptidase B from Trypanosoma brucei, a New Member of an Emerging Subgroup of Serine Oligopeptidases* (1999) (81)
- The Exocytosis-Regulatory Protein Synaptotagmin VII Mediates Cell Invasion by Trypanosoma cruzi (2001) (79)
- Trypanosoma cruzi invade a mammalian epithelial cell in a polarized manner (1988) (78)
- Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes (2010) (74)
- Dual Role of Signaling Pathways Leading to Ca2+ and Cyclic AMP Elevation in Host Cell Invasion byTrypanosoma cruzi (2000) (73)
- Mapping of surface glycoproteins of Trypanosoma cruzi by two-dimensional electrophoresis. A correlation with the cell invasion capacity. (1984) (73)
- Cell Invasion by Un‐Palatable Parasites (2000) (72)
- Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII. (2007) (68)
- LFR1 Ferric Iron Reductase of Leishmania amazonensis Is Essential for the Generation of Infective Parasite Forms* (2011) (65)
- Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts. (1997) (65)
- Control of Parasitophorous Vacuole Expansion by LYST/Beige Restricts the Intracellular Growth of Leishmania amazonensis (2008) (64)
- Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes (2015) (59)
- Lysosome recruitment during host cell invasion by Trypanosoma cruzi. (1995) (58)
- Leishmania-Mediated Inhibition of Iron Export Promotes Parasite Replication in Macrophages (2014) (58)
- The small chemical vacuolin‐1 alters the morphology of lysosomes without inhibiting Ca2+‐regulated exocytosis (2005) (56)
- Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. (2011) (56)
- PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. (2016) (53)
- Membrane Cholesterol Removal Changes Mechanical Properties of Cells and Induces Secretion of a Specific Pool of Lysosomes (2013) (51)
- Substrate Recognition Properties of Oligopeptidase B from Salmonella enterica Serovar Typhimurium (2002) (49)
- Surface‐targeted lysosomal membrane glycoprotein‐1 (Lamp‐1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi (2000) (45)
- Membrane repair and immunological danger (2005) (44)
- Lysosomes and the plasma membrane (2002) (43)
- From lysosomes into the cytosol: the intracellular pathway of Trypanosoma cruzi. (1994) (42)
- The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence (2017) (42)
- Above the fray: Surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair. (2015) (42)
- Heme Uptake Mediated by LHR1 Is Essential for Leishmania amazonensis Virulence (2013) (41)
- Characterization of a 21kDa protein from Trypanosoma cruzi associated with mammalian cell invasion. (2009) (39)
- Pathways of iron acquisition and utilization in Leishmania. (2013) (39)
- Cytolysins from intracellular pathogens. (1994) (38)
- Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei (2005) (37)
- Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells (2013) (36)
- Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter. (2010) (36)
- IRONy OF FATE: role of iron-mediated ROS in Leishmania differentiation. (2013) (36)
- Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development. (2010) (35)
- A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence (2016) (35)
- Opsonization Modulates Rac-1 Activation during Cell Entry by Leishmania amazonensis (2002) (34)
- A factor from Trypanosoma cruzi induces repetitive cytosolic free Ca2+ transients in isolated primary canine cardiac myocytes (1996) (33)
- Trypanosoma cruzi: protection in mice immunized with 8-methoxypsoralen-inactivated trypomastigotes. (1985) (33)
- The acid-active hemolysin of Trypanosoma cruzi. (1990) (29)
- Developmentally regulated expression of ceramide in Trypanosoma cruzi. (1996) (28)
- Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity. (2003) (28)
- Lipid raft–dependent plasma membrane repair interferes with the activation of B lymphocytes (2015) (27)
- Membrane Resealing: Synaptotagmin VII Keeps Running the Show (2005) (27)
- Approaches for plasma membrane wounding and assessment of lysosome-mediated repair responses. (2015) (25)
- Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes. (1998) (25)
- Don't bother to knock--the cell invasion strategy of Trypanosoma cruzi. (2002) (25)
- Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition (2018) (24)
- Phagolysosomal escape by intracellular pathogens. (1991) (23)
- The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis (2015) (23)
- Expression and Function of Synaptotagmin VII in CTLs (2007) (21)
- Expression and Function of Synaptotagmin VII in CTLs1 (2007) (21)
- Role for sialic acid in the formation of tight lysosome-derived vacuoles during Trypanosoma cruzi invasion. (2002) (21)
- Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells. (2009) (20)
- Living dangerously: how Trypanosoma cruzi uses lysosomes to get inside host cells, and then escapes into the cytoplasm. (1993) (20)
- Oxidative stress and intracellular infections: more iron to the fire. (2012) (20)
- A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity (2018) (19)
- Detection of Lysosomal Exocytosis by Surface Exposure of Lamp1 Luminal Epitopes. (2017) (19)
- Behave as Ca 2 1-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells (1997) (18)
- Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei (2006) (18)
- Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome‐mediated parasite invasion and plasma membrane repair (2019) (18)
- Live imaging assay for assessing the roles of Ca2+ and sphingomyelinase in the repair of pore-forming toxin wounds. (2013) (16)
- The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds (2015) (13)
- ESCRT: nipping the wound in the bud? (2014) (13)
- Surface Determinants in American Trypanosomes (1981) (12)
- Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease (2019) (12)
- Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion. (2011) (11)
- Presence of antibodies to the major surface glycoprotein of Trypanosoma cruzi amastigotes in sera from Chagasic patients. (1989) (10)
- The plasma membrane repair shop: Fixing the damage. (2015) (10)
- Leishmania infection inhibits macrophage motility by altering F‐actin dynamics and the expression of adhesion complex proteins (2017) (10)
- Trypanosoma cruzi and Chagas' Disease (2007) (10)
- ROS regulate differentiation of visceralizing Leishmania species into the virulent amastigote form. (2018) (9)
- Trypanosoma cruzi invades synaptotagmin VII-deficient cells by a PI-3 kinase independent pathway. (2005) (8)
- Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. (2019) (7)
- How do bone cells secrete proteins? (2010) (7)
- Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells (2021) (7)
- Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites. (2018) (6)
- Intracellular iron availability modulates the requirement for Leishmania Iron Regulator 1 (LIR1) during macrophage infections. (2019) (6)
- Trypanosoma cruzi: mechanisms of cell-invasion and intracellular survival. (1988) (6)
- Stage-specific surface antigens during the morphogenesis of Trypanosoma cruzi: developmentally regulated expression of a glycosyl-phosphatidylinositol anchored glycoprotein of amastigotes. (1988) (5)
- Two-way traffic on the road to membrane repair A for plasma membrane (2009) (5)
- Endophilin-A2-dependent tubular endocytosis promotes plasma membrane repair and parasite invasion (2020) (4)
- Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase (2020) (4)
- Why do so many surface proteins of trypanosomatids have GPI-anchors? (1991) (3)
- Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence (2019) (3)
- Membrane Resealing Mediated by Lysosomal Exocytosis (2005) (3)
- VII Regulates Ca 2 1-dependent Exocytosis of Lysosomes in Fibroblasts (2000) (2)
- Endophilin-A2 dependent tubular endocytosis promotes plasma membrane repair and parasite invasion. (2020) (2)
- Author response: Caveolae internalization repairs wounded cells and muscle fibers (2013) (2)
- Leishmania amazonensis Rab7 promotes toxicity of the amino acid ester Leu-OMe in amastigote megasomes. (2003) (2)
- Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells (2020) (2)
- Cholesterol access aids pathogen spread (2020) (1)
- A new source of reactive oxygen species in Leishmania amazonensis: Characterization of a heme-activated NADPH oxidase-like (2018) (1)
- Regulated exocytosis of lysosomes: A novel pathway revealed by the interaction of Trypanosoma cruzi with host cells (1999) (1)
- Host–microbe interactions: parasites (2000) (1)
- Resisting attack by repairing the damage. (2022) (1)
- Causative Agents of American Tegumentary Leishmaniasis Are Able to Infect 3T3-L1 Adipocytes In Vitro (2022) (1)
- Leishmania spp. and Leishmaniasis (2007) (0)
- VII in CTLs Expression and Function of Synaptotagmin (2007) (0)
- Regulated exocytosis and trypanosome invasion: the unexpected link (2000) (0)
- Trypanosoma cruzi Invasion by and Cyclic AMP Elevation in Host Cell 2+ Ca Dual Role of Signaling Pathways Leading to (2014) (0)
- Heme deprivation increases LHR1 expression and promotes uptake of the heme analog ZnMP by L. amazonensis promastigotes. (2013) (0)
- The best of times for protozoan microbiology. (2000) (0)
- Calcium dependent exocytosis and endocytosis: novel trafficking pathways revealed by the study of host/pathogen interactions (2009) (0)
- Sexually transmitted diseases: a review. (1997) (0)
- Expression and Function of Synaptotagmin (2017) (0)
- Mechanism of B cell membrane repair and the effects of repair on B cell receptor activation (IRC3P.460) (2014) (0)
- Response to "Shaky Ground for Lysosome-Dependent Membrane Repair" (2005) (0)
- Faculty Opinions recommendation of Prokaryotic origin of the actin cytoskeleton. (2001) (0)
- A Cytosolic Serine Endopeptidase from Trypanosoma cruzi Is Required for the Generation of Ca 2 (cid:49) Signaling in Mammalian Cells (1997) (0)
- Related biobytes podcast (2008) (0)
- Strategies for cell invasion and intracellular survival (2007) (0)
- Author response: Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells (2021) (0)
- Editorial overview: Host-microbe interactions: parasites 2019 - publisher's note. (2019) (0)
- THE MECHANISMS OF TRYPANOSOMA CRUZ) INV ASION OF MAMMALIAN CELLS (1995) (0)
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