Norman Giles
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American geneticist
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Norman Gilesbiology Degrees
Biology
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#3352
Historical Rank
#955
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Genetics
#353
World Rank
#415
Historical Rank
#154
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Biology
Norman Giles's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Genetics Stanford University
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Why Is Norman Giles Influential?
(Suggest an Edit or Addition)According to Wikipedia, Norman Henry Giles was an American microbial geneticist who studied mutations of Neurospora crassa. Norman H. Giles was a pioneer in genetics research. He was a member of the Botany Department at Yale University starting as an Instructor in Botany and rising to Professor of Biology . He then became Professor of Genetics . In 1972 Giles accepted a professorship at the University of Georgia where he established an active program in genetics that in 1980 became the Department of Genetics. He retired in 1986. Giles made important scientific contributions in the areas of intragenic complementation, gene conversion and analysis of gene clusters. His early work on intragenic complementation led to the insight that complementation between allelic mutants is of widespread occurrence and likely involves interactions occurring in the cytoplasm between defective gene products, that is between polypeptides. This early insight led to numerous further studies of intragenic complementation that amplified this initial insight .
Norman Giles's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Efficient transformation of Neurospora crassa by utilizing hybrid plasmid DNA. (1979) (303)
- Induced biochemical mutations in Bacillus subtilis. (1947) (285)
- Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa. (1985) (147)
- DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa. (1989) (145)
- Human chromosome complements in normal somatic cells in culture. (1959) (119)
- Studies on the mechanism of reversion in biochemical mutants of Neurospora crassa. (1951) (119)
- Expression of qa-1F activator protein: identification of upstream binding sites in the qa gene cluster and localization of the DNA-binding domain (1987) (98)
- A gene cluster in Nuerospora crassa coding for an aggregate of five aromatic synthetic enzymes. (1967) (97)
- Expression in Escherichia coli K-12 of the structural gene for catabolic dehydroquinase of Neurospora crassa. (1977) (89)
- Organization of Enzymes in the Common Aromatic Synthetic Pathway: Evidence for Aggregation in Fungi (1969) (88)
- The cytogenetic effect of slow neutrons. (1950) (83)
- Organization of Enzymes in the Polyaromatic Synthetic Pathway: Separability in Bacteria (1969) (81)
- Identification and characterization of recombinant plasmids carrying the complete qa gene cluster from Neurospora crassa including the qa-1+ regulatory gene. (1981) (80)
- Spontaneous Chromosome Aberrations in Tradescantia. (1940) (79)
- Genetic control of nitrate reductase in Neurospora crassa. (1965) (71)
- Studies on the mechanism of the oxygen effect on the radiosensitivity of Tradescantia chromosomes. (1950) (70)
- The occurrence of two dehydroquinases in Neurospora crassa, one constitutive and one inducible. (1967) (68)
- Genetic regulation of the qa gene cluster of Neurospora crassa: induction of qa messenger ribonucleic acid and dependency on qa-1 function (1981) (67)
- THE GENETIC CONTROL OF ADENYLOSUCCINASE IN Neurospora Crassa. (1957) (67)
- THE EFFECT OF FAST NEUTRONS ON THE CHROMOSOMES OF TRADESCANTIA. (1940) (66)
- Organization of Polyaromatic Biosynthetic Enzymes in a Variety of Photosynthetic Organisms (1970) (58)
- Types and frequencies of human chromosome aberrations induced by x-rays. (1961) (57)
- Recombination mechanisms at the pan-2 locus in Neurospora crassa. (1958) (55)
- The Wilhelmine E. Key 1989 invitational lecture. Organization and regulation of the qa (quinic acid) genes in Neurospora crassa and other fungi. (1991) (55)
- Comparative Studies of the Cytogenetical Effects of Neutrons and X-Rays. (1943) (53)
- The effect of oxygen on the frequency of X-ray induced chromosomal rearrangements in Tradescantia microspores. (1949) (52)
- The Organization, Function, and Evolution of Gene Clusters in Eucaryotes (1978) (50)
- ALLELIC RECOMBINATION IN NEUROSPORA: TETRAD ANALYSIS OF A THREE-POINT CROSS WITHIN THE PAN-2 LOCUS. (1964) (49)
- Characterization and in vitro translation of polyadenylated messenger ribonucleic acid from Neurospora crassa (1977) (48)
- Genetic organization and transcriptional regulation in the qa gene cluster of Neurospora crassa. (1981) (48)
- Comparative Studies of Monoepoxides as Inducers of Reverse Mutations in Neurospora. (1955) (47)
- Isolation and characterization of nuclei from Neurospora crassa (1977) (46)
- EVIDENCE FROM TETRAD ANALYSIS FOR BOTH NORMAL AND ABERRANT RECOMBINATION BETWEEN ALLELIC MUTANTS IN Neurospora Crassa. (1958) (46)
- COMPLEMENTATION AT THE AD-4 LOCUS IN NEUROSPORA CRASSA. (1958) (44)
- Complementation at the adenylosuccinase locus in Aspergillus nidulans. (1965) (42)
- Mutants in the arom gene cluster of Neurospora crassa specific for biosynthetic dehydroquinase. (1969) (40)
- Genetic evidence on the organization and action of the qa-1 gene product: a protein regulating the induction of three enzymes in quinate catabolism in Neurospora crassa. (1975) (40)
- The effect of X-irradiation in oxygen and in hydrogen at normal and positive pressures on chromosome aberration frequency in Tradescantia microspores. (1950) (38)
- Purification and properties of the aromatic (arom) synthetic enzyme aggregate of Neurospora crassa. (1969) (38)
- 5'-Untranslated sequences of two structural genes in the qa gene cluster of Neurospora crassa. (1982) (37)
- COMPARATIVE COMPLEMENTATION AND GENETIC MAPS OF THE PAN-2 LOCUS IN NEUROSPORA CRASSA. (1960) (37)
- Induced reversions of biochemical mutants in Neurospora crassa. (1948) (36)
- Evidence for nonsense mutations in the arom gene cluster of Neurospora crassa. (1968) (35)
- Purification of the arom multienzyme aggregate from Euglena gracilis. (1979) (34)
- The Effect of Oxygen on the Production by Fast Neutrons of Chromosomal Aberrations in Tradescantia Microspores. (1952) (33)
- Purification and characterization of catabolic dehydroquinase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa. (1975) (32)
- Genetical and biochemical evidence for further interrelationships between the polyaromatic synthetic and the quinate-shikimate catabolic pathways in Neurospora crassa. (1972) (32)
- A Study of Primate Chromosome Complements (1957) (32)
- The qa repressor gene of Neurospora crassa: wild-type and mutant nucleotide sequences. (1986) (32)
- Purification and characterization of quinate (shikimate) dehydrogenase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa. (1978) (31)
- Increased expression of a eukaryotic gene in Escherichia coli through stabilization of its messenger RNA. (1979) (31)
- Spontaneous Chromosome Aberrations in Triploid Tradescantia Hybrids. (1941) (30)
- Constitutive mutants in a regulatory gene exerting positive control of quinic acid catabolism in Neurospora crassa. (1971) (29)
- The Effect of Radiation Dose Fractionation on Chromosome Aberration Frequencies in Tradescantia Microspores. I. Studies with X-Rays. (1953) (28)
- Partial enzyme aggregates formed by pleiotropic mutants in the arom gene cluster of Neurospora crassa. (1971) (28)
- Genetic control of chromatin structure 5' to the qa-x and qa-2 genes of Neurospora. (1985) (27)
- Genetical and biochemical aspects of quinate breakdown in the filamentous fungus Aspergillus nidulans (1982) (27)
- Transcription and translation in E. coli of hybrid plasmids containing the catabolic dehydroquinase gene from Neurospora crassa. (1978) (26)
- AUTOPOLYPLOIDY AND GEOGRAPHICAL DISTRIBUTION IN CUTHBERTIA GRAMINEA SMALL (1942) (26)
- Purification and stability of the multienzyme complex encoded in the arom gene cluster of Neurospora crassa. (1972) (26)
- Cis-acting and trans-acting regulatory mutations define two types of promoters controlled by the qa-1F gene of Neurospora (1984) (24)
- THE NATURE OF COMPLEMENTATION AMONG MUTANTS IN THE HISTIDINE-3 REGION OF NEUROSPORA CRASSA. (1964) (24)
- Chimeric plasmid that replicates autonomously in both Escherichia coli and Neurospora crassa. (1983) (24)
- Purification and characterization of 3-dehydroshikimate dehydratase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa. (1978) (23)
- CHROMOSOMAL EFFECTS OF LOW X-RAY DOSES ON FIVE-DAY TRADESCANTIA MICROSPORES (1942) (23)
- Genetic Control of Neurospora malate dehydrogenase and aspartate aminotransferase: I. Mutant selection, linkage, and complementation studies (1965) (23)
- Autogenous regulation of the positive regulatory qa-1F gene in Neurospora crassa (1985) (22)
- Structure of a Neurospora RNA polymerase I promoter defined by transcription in vitro with homologous extracts. (1985) (22)
- Accurate transcription of cloned Neurospora RNA polymerase II-dependent genes in vitro by homologous soluble extracts. (1985) (22)
- Forward and back mutation at specific loci in Neurospora. (1956) (22)
- THE EFFECT OF OXYGEN ON THE INDUCTION OF CHROMATID ABERRATIONS IN TRADESCANTIA MICROSPORES BY X-IRRADIATION (1952) (22)
- Chromosomal interchanges induced in tradescantia microspores by fast neutrons from uranium fission. (1950) (20)
- Point mutations and DNA rearrangements 5' to the inducible qa-2 gene of Neurospora allow activator protein-independent transcription. (1983) (18)
- Characterization of qa-2 mutants of Neurospora crassa by genetic, enzymatic, and immunological techniques (1977) (17)
- The Effect of a Suppressor on Allelic Inositolless Mutants in Neurospora Crossa. (1953) (17)
- CYTOGENETICAL EFFECTS OF INTERNAL RADIATIONS FROM RADIOISOTOPES (1948) (17)
- Cloning the quinic acid (aq) gene cluster from Neurospora crassa: identification of recombinant plasmids containing both qa-2+ and qa-3+. (1981) (16)
- Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa (1985) (16)
- Genetic regulation of Quinate-Shikimate Catabolism in Neurospora Crassa (1973) (16)
- Effect of Linear Energy Transfer on Radiation-Induced Chromosome Aberrations in Tradescantia Microspores. (1954) (16)
- The Effect of Radiation Dose Fractionation on Chromosome Aberration Frequencies in Tradescantia Microspores. II. Studies with Fast Neutrons. (1953) (16)
- Studies with Purple Adenine Mutants in Neurospora Crassa. II. Tetrad Analyses from a Cross of an Ad-3a Mutant with an Ad-3b Mutant. (1957) (16)
- DNase I hypersensitive sites within the inducible qa gene cluster of Neurospora crassa. (1986) (15)
- Direct induction in wild-type Neurospora crassa of mutants (qa-1 c ) constitutive for the catabolism of quinate and shikimate. (1972) (14)
- In vivo and in vitro complementation between DHQ synthetase mutants in the arom gene cluster of Neurospora crassa. (1969) (14)
- Characterization of Neurospora crassa catabolic dehydroquinase purified from N. crassa and Escherichia coli. (1982) (13)
- THE EFFECT OF DEHYDRATION ON MICROSPOROGENESIS IN TRADESCANTIA (1939) (13)
- Chromosome Behavior at Meiosis in Triploid Tradescantia Hybrids (1941) (13)
- Comparative studies of x-ray-induced forward and reverse mutation. (1955) (12)
- Revertants and secondary arom-2 mutants induced in non-complementing mutants in the arom gene cluster of Neurospora crassa. (1974) (12)
- Chromosome Structural changes in Tradescantia Microspores Produced by Absorbed Radiophosphorus. (1947) (12)
- The cloning and analysis of the aroD gene of E. coli K-12. (1981) (11)
- Identification of major accumulation products of adenine-specific mutants of Neurospora. (1957) (11)
- Studies of Adenylosuccinase in Mutants and Revertants of Neurospora Crassa. (1960) (11)
- Studies of aromatic biosynthetic and catabolic enzymes in Ustilago maydis and in mutants of U. violacea (1972) (10)
- Proof of de novo synthesis of the qa enzymes of Neurospora crassa during induction. (1977) (10)
- Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids " (10)
- ALLELIC COMPLEMENTATION AT THE ADENYLOSUCCINASE LOCUS IN SCHIZOSACCHAROMYCES POMBE. (1964) (9)
- The oxygen effect on radiation-induced chromosome aberrations: breakage-versus-recombination hypotheses. (1955) (9)
- Identification and characterization of recombinant plasmids carrying the complete qa gene cluster from Neurospora crassa including the qa-l+ regulatory gene (9)
- COMPARATIVE BIOCHEMICAL STUDIES OF ALLELIC INOSITOLLESS MUTANTS IN NEUROSPORA CRASSA (1953) (8)
- Expression of the structural gene for catabolic dehydroquinase of Neurospora crassa in Escherichia coli K12. (1977) (8)
- Accurate transcription of homologous 5S rRNA and tRNA genes and splicing of tRNA in vitro by soluble extracts of Neurospora. (1984) (8)
- The Origin of Iso-Chromosomes at Meiosis. (1943) (8)
- Rearrangement mutations on the 5' side of the qa-2 gene of Neurospora implicate two regions of qa-1F activator-protein interaction. (1986) (8)
- A Pericentric Inversion in Gasteria Resulting in Apparent Iso-Chromosomes at Meiosis. (1944) (7)
- Studies of reverse mutation in Neurospora crassa. (1953) (7)
- Sedimentation Behaviour of Adenylsuccinase formed by Interallelic Complementation in Neurospora crassa (1963) (7)
- Gene order in the qa gene cluster of Neurospora crassa (1976) (6)
- Organization of interrelated aromatic metabolic pathway enzymes in Acinetobacter calco-aceticus. (1973) (6)
- The problem of mitotic recombination in Neurospora (1962) (6)
- Temperature-sensitive pleiotropic revertants from a mutant in the arom gene cluster of Neurospora crassa. (1974) (6)
- Evidence from tetrad analysis for both normal crossing over and gene conversion at the pan-2 locus in Neurospora crassa (1957) (6)
- Regulation of the QA gene cluster of Neurospora crassa (2004) (6)
- Genetical and biochemical characterization of QA-3 mutants and revertants in the QA gene cluster of Neurospora crassa. (1978) (6)
- The effect of oxygen on the frequency of X-ray induced chromosomal aberrations in Tradescantia microspores. (1950) (5)
- Organization of the qa gene cluster in Neurospora crassa: direction of transcription of the qa-3 gene. (1979) (5)
- Effect of mutations in the qa gene cluster of Neurospora crassa on the enzyme catabolic dehydroquinase (1975) (5)
- Expression of qa-lF Activator Protein: Identification of Upstream Binding Sites in the qa Gene Cluster and Localization of the DNA-Binding Domain (4)
- THE OXYGEN EFFECT ON X-RAY-INDUCED CHROMATID ABERRATIONS IN TRADESCANTIA MICROSPORES (1952) (4)
- THE RELATION BETWEEN THE EFFECTS OF TEMPERATURE AND OF OXYGEN ON THE FREQUENCY OF X-RAY-INDUCED CHROMOSOME ABERRATIONS IN TRADESCANTIA MICROSPORES (abstract) (1952) (4)
- TWO PAIRS OF ISOZYMES IN THE AROMATIC BIOSYNTHETIC AND CATABOLIC PATHWAYS IN NEUROSPORA CRASSA (1975) (3)
- A leucine tRNA gene adjacent to the QA gene du of Neurospora crassa (1984) (3)
- A leucine tRNA gene adjacent to the QA gene cluster of Neurospora crassa. (1984) (2)
- Induced reversions of biochemical mutants in Neurospora. (1948) (2)
- The occurrence of suppressors in a methionineless mutant of Neurospora.. (1950) (2)
- Organization ofEnzymes inthePolyaromatic Synthetic Pathway: Separability inBacteria (1969) (1)
- "Investigations on the cytogenetic effects of radiation". (1960) (0)
- A method for obtaining double mutants within single genes or gene clusters (1967) (0)
- Studies on mechanisms of mutation, recombination, and gene action in neurospora. Final technical report (1972) (0)
- Constitutive expression in Escherichia coli of the Neurospora crassa structural gene encoding the inducible enzyme catabolic dehydroquinase (1979) (0)
- Induced revertants of biochemical mutants of Neurospora crassa: personal recollections. (1999) (0)
- Genetic crassa: Regulation of the qa Gene Cluster of Neurospora Induction of qa Messenger Ribonucleic Acid and Dependency on qa-1 Function (0)
- STUDIES ON THE DEVELOPMENT OF THE EYE : EVIDENCE THAT 1 HE LOBE 2 , LOBE 4 , LOBE 5 AND EYELESS 2 MUTANTS OF DROSOPHILA MELANOGASTER DEVELOP IN A MANNER SIMILAR TO BAR (2005) (0)
- Genetic organization andtranscriptional regulation intheqagene cluster ofNeurospora crassa (1981) (0)
- Book Review:The Native Trees of Florida. Erdman West, Lillian E. Arnold (1950) (0)
- MUTANTS IN THE mom GENE CLUSTER OF NEUROSPORA CRASSA SPECIFIC FOR BIOSYNTHETIC DEHYDROQUINASEl (2003) (0)
- Letter from Norman H. Giles to Joshua Lederberg (1947) (0)
- IN VIVO AND IN VITRO COMPLEMENTATION BETWEEN DHQ OF NEUROSPORA CRASSA SYNTHETASE MUTANTS IN THE AROM GENE CLUSTER (1969) (0)
- Autogenous Regulation ofthePositive Regulatory qa-JFGene inNeurospora crassa (1985) (0)
- Gorrick, M. D. a Simple Expedient for Obtaining Iorge Quantities of Neurospom. Typically, Using Strain C-b4 (hist-1) Grown on Medium N (vogel 1956 Microbial Genet. Bull. 13:42) Supplemented with 53 (0)
- THE EFFECT OF RADIATION DOSE FRACTIONATION ON CHROMOSOME ABERRATION FREQUENCIES IK TRADESCANTIA MICROSPORES. NEUTRONS (1953) (0)
- Technical notes on the isolation of Neurospora nuclei (1977) (0)
- Nucleic Acids Research (2003) (0)
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