Norman Sharpless
#16,530
Most Influential Person Now
American cancer researcher
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Norman Sharplessmedical Degrees
Medical
#212
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#320
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#99
USA Rank
Oncology
#32
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#34
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#11
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Norman Sharplesslaw Degrees
Law
#2013
World Rank
#2505
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#950
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Common Law
#89
World Rank
#97
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#19
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Medical Law
Norman Sharpless's Degrees
- Bachelors English University of North Carolina at Chapel Hill
- Doctorate Medicine University of North Carolina at Chapel Hill
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Why Is Norman Sharpless Influential?
(Suggest an Edit or Addition)According to Wikipedia, Norman Edward "Ned" Sharpless is the previous Director of the National Cancer Institute . Before that, Sharpless was Professor of Medicine and Genetics Chair, Director of University of North Carolina UNC Lineberger Comprehensive Cancer Center, Molecular Therapeutics, Wellcome Distinguished Professorship in Cancer Research.
Norman Sharpless's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Circular RNAs are abundant, conserved, and associated with ALU repeats. (2013) (3234)
- Genomic Classification of Cutaneous Melanoma (2015) (2143)
- Detecting and characterizing circular RNAs (2014) (1944)
- Ink4a/Arf expression is a biomarker of aging. (2004) (1377)
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice (2015) (1122)
- Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a (2006) (1083)
- p16INK4a induces an age-dependent decline in islet regenerative potential (2006) (992)
- LKB1 modulates lung cancer differentiation and metastasis (2007) (975)
- The Regulation of INK4/ARF in Cancer and Aging (2006) (967)
- Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing (2006) (945)
- Senescence in Health and Disease (2017) (875)
- How stem cells age and why this makes us grow old (2007) (847)
- Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis (2001) (840)
- Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010) (801)
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. (2017) (717)
- Forging a signature of in vivo senescence (2015) (704)
- Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. (2002) (698)
- Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer (2012) (668)
- Telomeres, stem cells, senescence, and cancer. (2004) (485)
- Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation (2002) (454)
- INK4a/ARF: a multifunctional tumor suppressor locus. (2005) (448)
- The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. (2006) (440)
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response (2012) (439)
- Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis (2012) (421)
- The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population (2012) (416)
- CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. (2017) (382)
- Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging (2009) (357)
- Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development (2006) (342)
- COVID-19 and cancer (2020) (320)
- Constitutive telomerase expression promotes mammary carcinomas in aging mice (2002) (311)
- Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model (2013) (305)
- Somatic LKB1 Mutations Promote Cervical Cancer Progression (2009) (278)
- INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis (2009) (269)
- p53 Good Cop/Bad Cop (2002) (264)
- CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control (2008) (239)
- Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. (2012) (235)
- Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. (2010) (230)
- Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. (1985) (223)
- The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis (2004) (223)
- ROS as a tumour suppressor? (2006) (218)
- Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. (2014) (204)
- Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection (2021) (197)
- p19ARF targets certain E2F species for degradation (2001) (185)
- Review: a meta‐analysis of GWAS and age‐associated diseases (2012) (174)
- Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles. (2008) (166)
- RNA expression analysis of formalin-fixed paraffin-embedded tumors (2007) (163)
- Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. (2010) (160)
- Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence (2019) (157)
- Cancer: Crime and punishment (2005) (156)
- Ink4a/Arf links senescence and aging (2004) (153)
- Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. (2014) (153)
- ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence (2007) (152)
- A Phase II Study of Troglitazone, an Activator of the PPARγ Receptor, in Patients with Chemotherapy‐Resistant Metastatic Colorectal Cancer (2002) (143)
- Coming of age: molecular drivers of aging and therapeutic opportunities. (2013) (134)
- An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation (2016) (134)
- Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models (2012) (132)
- Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. (2014) (130)
- HMGA2, MicroRNAs, and Stem Cell Aging (2008) (130)
- HIF2α cooperates with RAS to promote lung tumorigenesis in mice (Journal of Clinical Investigation (2009) 119, (2160-2170) doi:101172/JCI38443) (2009) (126)
- p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. (2009) (122)
- LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. (2012) (120)
- Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model (2003) (120)
- A mouse model of human oral-esophageal cancer. (2002) (119)
- Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. (2011) (118)
- Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. (2013) (111)
- Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo (2003) (110)
- CD200 is induced by ERK and is a potential therapeutic target in melanoma. (2007) (107)
- HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. (2009) (102)
- Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis (2006) (98)
- Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion (2017) (95)
- Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. (2007) (88)
- CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. (2014) (87)
- Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy (2021) (86)
- Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis (2018) (84)
- Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer (2013) (80)
- Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. (2008) (78)
- Enhancing Next‐Generation Sequencing‐Guided Cancer Care Through Cognitive Computing (2017) (75)
- Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer. (2017) (75)
- p16(INK4a) and p53 deficiency cooperate in tumorigenesis. (2002) (72)
- A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. (2002) (72)
- Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation (2011) (71)
- Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 (2017) (69)
- Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. (2007) (69)
- Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma. (2018) (68)
- Pharmacophor requirements of the aldose reductase inhibitor site. (1983) (66)
- Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice (2013) (64)
- Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. (2008) (63)
- Stem cell aging. (2009) (60)
- p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. (2014) (58)
- PARP and cancer--if it's broke, don't fix it. (2011) (53)
- Germline Analysis from Tumor–Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings (2016) (53)
- Lamellipodia are crucial for haptotactic sensing and response (2016) (52)
- Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. (2004) (51)
- Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma. (2014) (51)
- Expression of p16INK4a as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy (2012) (51)
- Co-Clinical Trials Demonstrate Superiority of Crizotinib to Chemotherapy in ALK-Rearranged Non–Small Cell Lung Cancer and Predict Strategies to Overcome Resistance (2013) (51)
- LKB1 and lung cancer: more than the usual suspects. (2008) (51)
- An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the genome (2016) (48)
- Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. (2016) (47)
- New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging. (2018) (47)
- Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma. (2003) (46)
- Defining the toxicology of aging. (2014) (45)
- Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging (2016) (45)
- LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues (2014) (43)
- Cancer biology: Gone but not forgotten (2007) (42)
- A quantitative model for age-dependent expression of the p16INK4a tumor suppressor (2009) (40)
- Impact papers on aging in 2009 (2010) (40)
- Genetic "lnc"-age of noncoding RNAs to human disease. (2012) (38)
- Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling (2013) (38)
- Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation (2010) (37)
- Supplementary Information for Cells exhibiting strong p 16 INK 4 a promoter activation in vivo display features of senescence (2019) (35)
- A Blueprint for Characterizing Senescence (2020) (35)
- Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC (2015) (34)
- Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4h-chromen ring system. (1978) (34)
- Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma (2014) (34)
- Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors. (2012) (33)
- RAS unplugged: negative feedback and oncogene-induced senescence. (2006) (33)
- Stereospecific inhibition of aldose reductase (1981) (32)
- EGFR Targeted Therapy: View from Biological Standpoint (2006) (31)
- p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. (2013) (30)
- Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults (2016) (29)
- Tumor suppressor mechanisms in immune aging. (2009) (28)
- Real-world data suggest antibody positivity to SARS-CoV-2 is associated with a decreased risk of future infection (2020) (26)
- Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications (1985) (25)
- Ovarian cancer: an update on genetics and therapy. (1998) (22)
- Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells (2009) (19)
- Coding of smooth eye movements in three-dimensional space by frontal cortex (19)
- p16Ink4a inhibits histologic progression and angiogenic signaling in min colon tumors (2005) (19)
- Stem cells and the rate of living. (2007) (19)
- Overexpression of the Cell Cycle Inhibitor p16INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice (2011) (18)
- Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review (2010) (18)
- Lythraceae alkaloids. X. Assignment of absolute stereochemistries on the basis of chiraloptical effects. (1971) (18)
- The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues (2013) (17)
- Modernizing Clinical Trials for Patients With Cancer. (2019) (17)
- Telomeres, p21 and the cancer-aging hypothesis (2007) (17)
- Drug efficacy testing in mice. (2012) (17)
- Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020. (2021) (16)
- The nuclear magnetic resonance of heterocyclic compounds related to anthracene (1974) (16)
- The aldose reductase inhibitor site. (1986) (15)
- Nature of the Unpaired Electron Orbital in Some Low Spin Oxygen-Co Complexes (1968) (15)
- IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma (2015) (15)
- Preparation and Immortalization of Primary Murine Cells (2006) (14)
- Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin (2013) (14)
- Identification of Human Papillomavirus Infection in Cancer Tissue by Targeted Next-generation Sequencing (2016) (13)
- Medical problems in patients with malignancy: case 2. Wernicke's encephalopathy: an unusual acute neurologic complication of lymphoma and its therapy. (2004) (13)
- The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma (2019) (11)
- Nuclear Magnetic Resonance of Compounds Related to DDT: Part II. Aromatic Protons (1968) (11)
- Impact papers on aging in 2009 - eScholarship (2010) (11)
- p16Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis (2004) (11)
- Expression of p 16 Ink 4 a Compensates for p 18 Ink 4 c Loss in Cyclin-Dependent Kinase 4 / 6 – Dependent Tumors and Tissues (2007) (11)
- The persistence of senescence. (2003) (10)
- Senescence‐escape in melanoma (2012) (10)
- Cancer as a Global Health Priority. (2021) (10)
- Stem cells: Down's syndrome link to ageing (2013) (10)
- Redoubling Efforts to Help Americans Quit Smoking - Federal Initiatives to Tackle the Country's Longest-Running Epidemic. (2020) (9)
- Progress and potential: the Cancer Moonshot. (2021) (9)
- The potential of AI in cancer care and research. (2021) (9)
- mTOR signaling in melanoma: oncogene-induced pseudo-senescence? (2015) (9)
- Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice. (2017) (8)
- Erratum: Circular RNAs are abundant, conserved, and associated with ALU repeats (RNA (156)) (2013) (8)
- VHL inactivation: a new road to senescence. (2008) (8)
- Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 (2017) (8)
- Competition for polymeric binding sites between acridine and triphenylmethane dyes. (1970) (7)
- ADVANCED OVARIAN CANCER : RECENT PROGRESS AND CURRENT CHALLENGES (1998) (7)
- What's so special about RB? (2010) (7)
- Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in All of Us Research Program Participants, 2 January to 18 March 2020 (2021) (7)
- Influence of structural factors in the acridines upon their therapeutic effectiveness. Quantum mechanical parameters. (1969) (7)
- Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are associated with p16INK4a Expression in Subjects on Combination Therapy (2016) (7)
- How Disruption of Cell Cycle Regulators Might Predispose to Sun-Induced Skin Cancer (2005) (7)
- Cancer Grand Challenges: Embarking on a New Era of Discovery. (2020) (6)
- Phospholipid—Retinaldehyde Complex absorbing at 500 nm (1970) (6)
- P16(INK4a)expression after chemotherapy in older women with early-stage breast cancer. (2011) (6)
- Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells (2009) (6)
- When the world turned cold (2007) (6)
- Expression of p16 is a biomarker of chondrocyte aging but does not cause osteoarthritis (2018) (6)
- Meeting Report : American Aging Association 40 th Annual Meeting , Raleigh , North Carolina , June 3 – 6 , 2011 (2011) (5)
- Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. (2017) (5)
- Arp2/3 complex is critical for lamellipodia and organization of cell-matrix adhesion but dispensable for fibroblast chemotaxis (2013) (5)
- The reaction of dimethyl β-ketoglutarate with 1,2-dicarbonyl compounds. III. -tetracyclo[5.5.1.02,6.010,13]tridecane-4,8,12-trione (1975) (4)
- Topical therapy for regression and melanoma prevention of congenital giant nevi (2022) (4)
- The LKB 1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues (2013) (4)
- Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection (2016) (4)
- 10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments (2008) (4)
- Abstract B103: Integrative genomic and proteomic analyses identify novel targets for Lkb1 deficient metastatic lung tumors (2009) (4)
- Advances in Brief p 16 INK 4 a and p 53 Deficiency Cooperate in Tumorigenesis 1 (2002) (4)
- Ink 4 a Interferes with Abelson Virus Transformation by Enhancing Apoptosis (2004) (4)
- Interactions between acridines and triphenyl methane dyes: their possible role in therapeutic interference. (1969) (4)
- A MOLECULAR MODEL FOR A PHOSPHOLIPID‐RETINALDEHYDE COMPLEX ABSORBING AT 500 nm (1971) (3)
- Mechanism of formation of Weiss' endo- and exo-tetracyclo[5.5.1.02,6.010,13]tridecane-4,8,12-trione (1983) (3)
- Elizabeth Blackburn and the story of telomeres:Deciphering the ends of DNA (2008) (3)
- The Impact of Aging on Cancer Progression and Treatment (2016) (3)
- Decreased IRF 8 Expression in Aging Hematopoietic Progenitor / Stem Cells (2008) (3)
- Hot topics in stem cells and self‐renewal: 2010 (2010) (3)
- Review: A Meta-Analysis of GWAS Studies and Age-Associated Diseases (2012) (3)
- Cancer Therapy : Preclinical Combined PI 3 K / mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models (2012) (3)
- A Trans-Governmental Collaboration to Independently Evaluate SARS-CoV-2 Serology Assays (2022) (3)
- Aldose reductase inhibition by anti-allergy drugs. (1982) (3)
- Inhibitors of cyclin dependent kinases and methods of use (2010) (2)
- p 16 INK 4 a protects against dysfunctional telomere – induced ATR-dependent DNA damage responses (2018) (2)
- Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. (2017) (2)
- Alternate g-g- conformation for dinucleoside phosphates in solution. (1982) (2)
- Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma (2014) (2)
- P4-17-04: Pharmacokinetic Disposition of PEGylated Liposomal Doxorubicin Compared with Non-Liposomal Doxorubicin in an Intracranial Breast Cancer Murine Model. (2011) (1)
- Advancing progress for patients with cancer through small business innovation research. (2020) (1)
- The combination of cyclin D1 overexpression and p53 inactivation is critical for oral-esophageal carcinogenesis in transgenic mice (2000) (1)
- Erratum: Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells (Leukemia (2008) 10.1038/leu.2008.176) (2009) (1)
- Changes in p16INK4a (p16) expression, a biomarker of aging, in peripheral blood T-cells (PBTC) in patients receiving anthracycline (A) vs non-anthracycline (NoA) chemotherapy (CRx) for early-stage breast cancer (EBC). (2017) (1)
- Abstract 5024: mDX400, the murine analog against the anti-PD1 antibody MK-347 is active in immunocompetent, autochthonous murine models of melanoma and breast cancer (2014) (1)
- Therapeutic interference studies: mechanisms of interpolymer competition for dyes. (1973) (1)
- G1T28, a CDK4/6 inhibitor, preserves T lymphocyte function from damage by cytotoxic chemotherapy (2016) (1)
- Type of Melanoma Mitogen-Activated Protein Kinase Signaling Shows a New Lack of Extracellular Signal-Regulated Kinase (2007) (1)
- Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy (2015) (1)
- Erratum: Forging a signature of in vivo senescence (2015) (1)
- Retinal Schiff bases: the effect of water on spectral absorption. (1973) (1)
- Amendment history : Corrigendum ( October 2009 ) HIF 2 a cooperates with RAS to promote lung tumorigenesis in mice (2018) (1)
- Defective cell cycle checkpoint response to DNA double strand breaks is associated with altered patterns of gene expression (2006) (0)
- Abstract IA11: Transient CDK4/6 inhibition protects hematopoietic progenitors from chemotherapy-induced exhaustion (2016) (0)
- SPECTROSCOPY AND CHEMICAL PHYSICS (1984) (0)
- Abstract 2285: Germline genetic variation modulates tumor latency and response to therapy in a mouse model of basal-like breast cancer (2015) (0)
- FDA guidance on interchangeable biological products (2019) (0)
- Managing advanced ovarian cancer (1997) (0)
- p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment. (2008) (0)
- Corrigendum to “Role of senescence marker p16INK4A measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults” [Exp. Gerontol. 74 (2016) 29–36] (2021) (0)
- A Telomere-Independent Process? (2008) (0)
- Abstract P1-05-20: Comparing the frequency and types of genetic aberrations between older and younger women with metastatic breast cancer at the University of North Carolina at Chapel Hill (2017) (0)
- Abstract P6-08-34:p16INK4aexpression and chemotherapy toxicity in women with early stage breast cancer (2015) (0)
- P16INK4aexpression after chemotherapy in older women with early-stage breast cancer. (2011) (0)
- Abstract SP143: Advancing Cancer Research During Challenging Times (2021) (0)
- Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma (2013) (0)
- Whole exome paraffin sequencing (WEPS) of same-patient (pt) primary, extracranial, and melanoma brain metastases (PEB) to identify new driver and clonal evolution genetic events. (2015) (0)
- Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16Ink4a/Arf-Independent manner (2011) (0)
- Abstract 2400: Differential phosphorylation of signaling targets as a function of RAS mutation status and tumor histology in non-small cell lung cancer. (2013) (0)
- Some aspects of Schiff bases of retinaldehyde. (1974) (0)
- Sustained p16INK4a expression is required to protect against IR-induced lymphoma in mice (2014) (0)
- The Nuclear Magnetic Resonance of DDT and Related Compounds. Part III: Naturally Occurring 13C Spectra (1985) (0)
- Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma. (2013) (0)
- Abstract 4203: Plasma and tumor pharmacokinetics (PK) of carboplatin in Genetically Engineered Mouse Models of melanoma (GEMMs), murine melanoma, and in patients with cutaneous melanoma (2010) (0)
- Chondrocyte-Specific Loss of the Branched Actin Mediator ARP2/3 Results in Growth Plate Fusion and Proteoglycan Loss in Articular Cartilage (2017) (0)
- Abstract 5271: p16-LUC: an in vivo reporter allele for de novo tumor formation and therapeutic response (2011) (0)
- Abstract B39: Multitarget approach against PI3K, Aurora kinase, and BRD4 leads to improved antitumor activity in Myc-overexpressing lymphoma cells (2015) (0)
- Cancer Informatics for Cancer Centers: Scientific Drivers for Informatics, Data Science, and Care in Pediatric, Adolescent, and Young Adult Cancer. (2021) (0)
- miR-29 is an important driver of aging-related phenotypes (2022) (0)
- 503 UNC2025: A small molecule inhibitor of merTK with efficacy in mouse melanoma models (2014) (0)
- Abstract 4382: Intravital imaging of endogenous BRAFV600E melanoma reveals plasticity of tumor response and resistance to trametinib over time (2016) (0)
- Abstract CT133: The impact of gene panel sequencing on clinical care in patients with cancer (2015) (0)
- Constitutive Activation of Ras and Inactivation of Ink4a/Arf Allele Induce a Fully Penetrant B-Cell Acute Lymphoblastic Leukemia Phenotype in Mice (2017) (0)
- Abstract CN03-01: Drug testing in genetically engineered murine models. (2013) (0)
- Impact papers on aging in 2009 Citation (2022) (0)
- CASE 3. Ulcerating Cytomegalovirus Bronchitis in a Patient With Relapsed Non-Hodgkin's Lymphoma (2004) (0)
- Novel Therapeutics in Renal Diseases CDK 4 / 6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury (2014) (0)
- Unexpected In Vivo Antagonism between Two Active Agents, Ionizing Radiation and the Farnesyltransferease Inhibitor lonafarnib, in a Genetically Engineered Murine Model of Ras-induced Melanoma (2008) (0)
- Abstract 4943: Visualization of endogenous melanoma initiation and progression using intravital microscopy (2014) (0)
- p16INK4a and Stem Cell Ageing: A Telomere-Independent Process? (2008) (0)
- 201 Gene Expression Profiling Identifies Loss of Fhit Expression Due to Epigenetic Silencing As a Frequent Event in African American (AA) Patients with Colorectal Cancer (CRC) (2009) (0)
- Abstract IA01: How the National Cancer Institute is working to reduce cancer health disparities (2020) (0)
- Abstract 4761: Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma (2014) (0)
- JCB_201404067 1..17 (2014) (0)
- Abstract PD6-07: Genomic sequencing in metastatic breast cancer patients to inform clinical practice at the University of North Carolina at Chapel Hill (2016) (0)
- Integrated microfluidic cytometer for the direct analysis of leukocytes in whole blood (2008) (0)
- Role of cellular senescence in the age‐associated risk of venous thrombosis (2009) (0)
- MECHANISM OF FORMATION OF WEISS′ ENDO- AND EXO-TETRACYCLO(5.5.1.02,6.010,13)TRIDECANE-4,8,12-TRIONE (1983) (0)
- CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control (cid:1) (2008) (0)
- Antiallergy drugs as aldose reductase inhibitors (1980) (0)
- The Biology and Genetics of Melanoma (2006) (0)
- Alisertib, an Aurora a Kinase Inhibitor, Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma Cells (2015) (0)
- Abstract 4499: Integration of targeted RNA sequencing to targeted DNA sequencing for the characterization of clinically relevant variants in a population of thousands of patients treated on clinical trial (2016) (0)
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