Núria López Bigas
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Researcher on computational cancer genomics
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Núria López Bigasbiology Degrees
Biology
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Computational Biology
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World Rank
#133
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Biology
Why Is Núria López Bigas Influential?
(Suggest an Edit or Addition)According to Wikipedia, Núria López Bigas is a Spanish biologist and research professor with expertise in medical genetics, computational biology, and bioinformatics. She is an ICREA professor at Pompeu Fabra University and she also leads the Biomedical Genomics Research Group at the Institute for Research in Biomedicine in Barcelona, Spain. Her research is focused on developing computational approaches to investigate cancer genomes.
Núria López Bigas's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007) (5196)
- International network of cancer genome projects (2010) (1839)
- The repertoire of mutational signatures in human cancer (2018) (1656)
- Comprehensive Characterization of Cancer Driver Genes and Mutations (2018) (1360)
- A Landscape of Pharmacogenomic Interactions in Cancer (2016) (1254)
- Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin (2014) (1192)
- Whole-genome landscapes of major melanoma subtypes (2017) (875)
- Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. (2011) (765)
- Pan-Cancer Network Analysis Identifies Combinations of Rare Somatic Mutations across Pathways and Protein Complexes (2014) (721)
- Expansion of the BioCyc collection of pathway/genome databases to 160 genomes (2005) (669)
- Non-coding recurrent mutations in chronic lymphocytic leukaemia (2015) (654)
- IntOGen-mutations identifies cancer drivers across tumor types (2013) (480)
- Comprehensive identification of mutational cancer driver genes across 12 tumor types (2013) (457)
- CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer (2017) (414)
- A compendium of mutational cancer driver genes (2020) (400)
- Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus (1999) (394)
- OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes (2013) (387)
- Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer (2009) (373)
- Are splicing mutations the most frequent cause of hereditary disease? (2005) (371)
- Comprehensive Characterization of Cancer Driver Genes and Mutations (2018) (340)
- Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations (2017) (337)
- Functional impact bias reveals cancer drivers (2012) (315)
- A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) (2018) (296)
- Pathway and network analysis of cancer genomes (2015) (285)
- Genome-wide identification of genes likely to be involved in human genetic disease. (2004) (277)
- In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities. (2015) (272)
- Gitools: Analysis and Visualisation of Genomic Data Using Interactive Heat-Maps (2011) (253)
- Nucleotide excision repair is impaired by binding of transcription factors to DNA (2015) (242)
- Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (2020) (220)
- OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations (2016) (206)
- SNP and haplotype mapping for genetic analysis in the rat (2008) (200)
- A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations (2017) (195)
- Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2 (2020) (185)
- Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia (2014) (185)
- Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene (1999) (176)
- BioMart Central Portal: an open database network for the biological community (2011) (165)
- Computational approaches to identify functional genetic variants in cancer genomes (2013) (161)
- Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes. (2014) (155)
- Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes (2006) (154)
- The mutational footprints of cancer therapies (2019) (154)
- Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression. (2013) (152)
- Regulation of plant stem cell quiescence by a brassinosteroid signaling module. (2014) (144)
- Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. (2008) (143)
- Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets (2016) (129)
- Transcriptional activation of polycomb-repressed genes by ZRF1 (2010) (126)
- Connexin 31 (GJB3) is expressed in the peripheral and auditory nerves and causes neuropathy and hearing impairment. (2001) (124)
- Reduced mutation rate in exons due to differential mismatch repair (2017) (120)
- Notch signal strength controls cell fate in the haemogenic endothelium (2015) (116)
- IntOGen: integration and data mining of multidimensional oncogenomic data (2010) (113)
- Local Determinants of the Mutational Landscape of the Human Genome (2019) (105)
- Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid (2018) (105)
- The A1555G mutation in the 12S rRNA gene of human mtDNA: recurrent origins and founder events in families affected by sensorineural deafness. (1999) (105)
- PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis (2012) (105)
- Differences in the evolutionary history of disease genes affected by dominant or recessive mutations (2006) (98)
- Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene. (2000) (97)
- Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation (2012) (96)
- The mutational landscape of chromatin regulatory factors across 4,623 tumor samples (2013) (96)
- Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2 (2014) (91)
- Structural and functional properties of genes involved in human cancer (2006) (91)
- The road ahead in genetics and genomics (2020) (88)
- Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase. (2015) (86)
- p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes (2012) (85)
- Visualizing multidimensional cancer genomics data (2013) (85)
- Connexin mutations in hearing loss, dermatological and neurological disorders. (2002) (82)
- Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes (2018) (79)
- A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (2020) (79)
- Whole genome analysis of p38 SAPK-mediated gene expression upon stress (2010) (71)
- Biological reprogramming in acquired resistance to endocrine therapy of breast cancer (2010) (69)
- Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation (2012) (69)
- A DNA methylation map of human cancer at single base-pair resolution (2017) (68)
- Comparison of algorithms for the detection of cancer drivers at subgene resolution (2017) (67)
- Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer (2021) (65)
- An oligo-based microarray offers novel transcriptomic approaches for the analysis of pathogen resistance and fruit quality traits in melon (Cucumis melo L.) (2009) (62)
- Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells (2015) (61)
- OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action (2014) (58)
- Highly consistent patterns for inherited human diseases at the molecular level (2006) (56)
- Functional protein divergence in the evolution of Homo sapiens (2008) (55)
- HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages (2013) (55)
- Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. (2011) (51)
- The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion (2013) (51)
- The whole-genome panorama of cancer drivers (2017) (50)
- Sample-level enrichment analysis unravels shared stress phenotypes among multiple cancer types (2012) (47)
- Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes (2017) (46)
- Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence (2014) (46)
- Improving data and knowledge management to better integrate health care and research (2013) (45)
- Genomic and evolutionary classification of lung cancer in never smokers (2021) (43)
- Prioritization of candidate cancer genes—an aid to oncogenomic studies (2008) (40)
- Splice‐site mutation in the PDS gene may result in intrafamilial variability for deafness in Pendred syndrome (1999) (40)
- Expression of Polycomb Targets Predicts Breast Cancer Prognosis (2013) (39)
- OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers (2018) (38)
- Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. (2013) (37)
- In silico saturation mutagenesis of cancer genes (2020) (37)
- Fast randomization of large genomic datasets while preserving alteration counts (2014) (37)
- mir-11 limits the proapoptotic function of its host gene, dE2f1. (2011) (36)
- Erratum: Identification of five new mutations of PDS/SLC26A4 in Mediterranean families with hearing impairment (2002) (36)
- Selective targeting of histone methylation (2011) (35)
- The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities (2020) (33)
- The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma (2015) (33)
- Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition (2016) (32)
- Beyond 100 genomes (2003) (31)
- Oncodrive-CIS: A Method to Reveal Likely Driver Genes Based on the Impact of Their Copy Number Changes on Expression (2013) (31)
- Pervasive lesion segregation shapes cancer genome evolution (2019) (29)
- Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea (2002) (29)
- On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees (2007) (29)
- jHeatmap: an interactive heatmap viewer for the web (2014) (29)
- Loss of dE2F compromises mitochondrial function. (2013) (28)
- A partially supervised classification approach to dominant and recessive human disease gene prediction (2007) (28)
- CoGenT++: an extensive and extensible data environment for computational genomics (2005) (26)
- Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program (2012) (26)
- Identification of five new mutations of PDS/SLC26A4 in Mediterranean families with hearing impairment (2001) (25)
- A harmonized meta-knowledgebase of clinical interpretations of cancer genomic variants (2018) (25)
- NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas (2014) (24)
- Biological Convergence of Cancer Signatures (2009) (24)
- Identification of seven novel SNPS (five nucleotide and two amino acid substitutions) in the connexin31 (GJB3) gene (2000) (22)
- The evolution of hematopoietic cells under cancer therapy (2020) (22)
- A common frameshift mutation and other variants in GJB4 (connexin 30.3): Analysis of hearing impairment families (2002) (22)
- Patterns of evolutionary constraints on genes in humans (2008) (22)
- An Intronic microRNA Links Rb/E2F and EGFR Signaling (2014) (21)
- Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer (2019) (20)
- Detection of early seeding of Richter transformation in chronic lymphocytic leukemia (2022) (20)
- Integrative Cancer Genomics (IntOGen) in Biomart (2011) (20)
- Discovering the drivers of clonal hematopoiesis (2020) (19)
- Inhibition of Specific NF-κB Activity Contributes to the Tumor Suppressor Function of 14-3-3σ in Breast Cancer (2012) (18)
- Co-Regulation of Histone-Modifying Enzymes in Cancer (2011) (18)
- R32W variant in Connexin 31: mutation or polymorphism for deafness and skin disease? (2001) (15)
- Distinct Patterns in the Regulation and Evolution of Human Cancer Genes (2008) (15)
- CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase (2018) (14)
- Mutations in the mitochondrial tRNA Ser(UCN) and in the GJB2 (connexin 26) gene are not modifiers of the age at onset or severity of hearing loss in Spanish patients with the 12S rRNA A1555G mutation. (2000) (14)
- Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites (2020) (13)
- Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets (2010) (12)
- Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria (2020) (11)
- Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea. (2002) (11)
- Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer (2021) (11)
- Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance (2015) (9)
- Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma. (2021) (9)
- The evolution of relapse of adult T cell acute lymphoblastic leukemia (2020) (8)
- Germline MBD4 deficiency causes a multi-tumor predisposition syndrome (2022) (8)
- Oncogenomics methods and resources. (2012) (8)
- A novel G21R mutation of the GJB2 gene causes autosomal dominant non-syndromic congenital deafness in a Cuban family (2006) (8)
- BnpC: Bayesian non-parametric clustering of single-cell mutation profiles (2020) (7)
- Are carcinogens direct mutagens? (2020) (7)
- High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer (2021) (7)
- muts-needle-plot: Mutations Needle Plot v0.8.0 (2015) (7)
- Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium (2016) (6)
- Thread 4: Data discovery, transparency and visualization (2013) (6)
- Rational design of cancer gene panels with OncoPaD (2016) (6)
- Abstract A1-45: In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals novel targeting opportunities (2015) (6)
- EU Pancreas: An Integrated European Platform for Pancreas Cancer Research - from Basic Science to Clinical and Public Health Interventions for a Rare Disease (2013) (5)
- Strand-resolved mutagenicity of DNA damage and repair (2022) (5)
- Germline loss-of-function variants in the base-excision repair gene MBD4 cause a Mendelian recessive syndrome of adenomatous colorectal polyposis and acute myeloid leukaemia (2021) (4)
- DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data (2021) (4)
- The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion (2013) (3)
- OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers (2019) (3)
- How to improve data and knowledge management to better integrate healthcare and research (2013) (3)
- Author Correction: The repertoire of mutational signatures in human cancer (2020) (2)
- Altered oncomodules underlie chromatin regulatory factors driver mutations (2016) (2)
- Bayesian non-parametric clustering of single-cell mutation profiles (2020) (2)
- Predicting disease variants using biodiversity and machine learning (2021) (2)
- Thread 2: Network models (2013) (2)
- Abstract 2983: In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals novel targeting opportunities (2015) (2)
- Genomic Data Improves Prognostic Stratification in Adult T-Cell Acute Lymphoblastic Leukemia Patients Enrolled in Measurable Residual Disease-Oriented Trials (2021) (2)
- Signatures 1 and 17 show increased propensity to create mutational hotspots in the human genome (2022) (2)
- A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (2020) (1)
- Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis (2018) (1)
- Abstract LB-401: Functional impact bias reveals cancer drivers (2012) (1)
- Patterns of Clonal Evolution Assessed By Whole Exome Sequencing during Progression from MDS to AML Are Related to Therapy (2016) (1)
- Author Correction: Reduced mutation rate in exons due to differential mismatch repair (2018) (1)
- Visualizing multidimensional cancer genomics data (2013) (1)
- Analysis of Pathogen Resistance and Fruit Quality Traits in Melon (Cucumis melo L.) (2011) (1)
- Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses (2021) (1)
- Resource A Landscape of Pharmacogenomic Interactions in Cancer Graphical Abstract Highlights (2016) (1)
- Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation (2012) (1)
- Erratum: Comprehensive identification of mutational cancer driver genes across 12 tumor types (2013) (1)
- Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (2020) (0)
- Mutations Needle Plot with JavaScript (2014) (0)
- Resource Reveals Molecular Classification Multiplatform Analysis of 12 Cancer Types within and across Tissues of Origin (0)
- Improving the assessment of the outcome of nonsynonymous SNVs with a CONsensus DELeteriousness score, Condel (2011) (0)
- Abstract 3795: Early seeding of Richter transformation in chronic lymphocytic leukemia (2022) (0)
- The mutational footprints of cancer therapies (2019) (0)
- The evolution of relapse of adult T cell acute lymphoblastic leukemia (2020) (0)
- Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions (2022) (0)
- Edinburgh Research Explorer Pervasive lesion segregation shapes cancer genome evolution (2020) (0)
- 4. Coordinating variant interpretation knowledgebases improves clinical interpretation of genomic variants in cancers (2018) (0)
- Toward Sézary Syndrome immunotherapy (2021) (0)
- Abstract 3282: Standardization and coordination of variant interpretation knowledgebases improves clinical genome actionability (2018) (0)
- leukemia major molecular and clinical subdivision in chronic lymphocytic Transcriptome characterization by RNA sequencing identifies a Material (2014) (0)
- Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia enrolled in measurable residual disease-oriented trials (2022) (0)
- P1.08-A Sherlock Lung Tracing Lung Cancer Mutational Processes in Never-smokers (2019) (0)
- Mutational and Clonal Dynamics During Progression from MDS to SAML by Whole-Exome and Targeted-Deep Sequencing (2017) (0)
- Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer (2021) (0)
- Properties of Genes involved in Human Genetic Disease (2004) (0)
- Predicting disease variants using biodiversity and machine learning (2021) (0)
- Abstract 2608: Global integration of knowledgebases for clinical interpretation of cancer variants (2017) (0)
- muts-needle-plot: Mutations Needle Plot v0.7.0 (2014) (0)
- Pervasive lesion segregation shapes cancer genome evolution (2020) (0)
- Rational design of cancer gene panels with OncoPaD (2016) (0)
- Contents continued (2002) (0)
- Abstract not submitted for online publication (2012) (0)
- Abstract 1061: EZH2 expression in different subtypes of human breast cancer (2012) (0)
- 455: The role of new cancer hallmarks in tumorigenesis (2014) (0)
- Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity (2023) (0)
- Author Correction: Reduced mutation rate in exons due to differential mismatch repair (2018) (0)
- SVGMap: configurable image browser for experimental data (2012) (0)
- Ten simple rules for a successful international consortium in big data omics (2022) (0)
- Copy number footprints of platinum-based anticancer therapies (2022) (0)
- Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer (2022) (0)
- OA04.05 MESOMICS Project: Using Whole-Genome Sequencing Data to Fill the Gaps in Malignant Pleural Mesothelioma Molecular Studies (2022) (0)
- Sample-level enrichment analysis unravels shared stress phenotypes among multiple cancer types (2012) (0)
- Thread 1: Mutational drivers (2013) (0)
- 46: Proffered Paper: Therapeutical landscape of cancer drivers (2014) (0)
- Global integration of knowledgebases for clinical interpretation of cancer variants (2017) (0)
- Abstract 1517: Molecular architecture of replication stress response to oncogene deregulation (2022) (0)
- The mutational landscape of chromatin regulatory factors across 4,623 tumor samples (2013) (0)
- OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations (2016) (0)
- Automatic interpretation of cancer genomes creates the largest repository of tumour genetic driver events (2019) (0)
- Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations (2018) (0)
- Analysis of clonal evolution in chronic lymphocytic leukemia from inactive to symptomatic disease prior treatment using whole-exome sequencing. (2016) (0)
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What Schools Are Affiliated With Núria López Bigas?
Núria López Bigas is affiliated with the following schools:
