Ori D. Rotstein
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(Suggest an Edit or Addition)Ori D. Rotstein's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial (1994) (889)
- Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. (2004) (607)
- Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. (1997) (351)
- Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. (1998) (344)
- Trial of short-course antimicrobial therapy for intraabdominal infection. (2015) (310)
- Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance. (2000) (287)
- Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. (1997) (232)
- Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition (2003) (230)
- Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. (1998) (226)
- Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification (1998) (221)
- Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages. (1990) (210)
- Integrity of Cell-Cell Contacts Is a Critical Regulator of TGF-1-Induced Epithelial-to-Myofibroblast (2004) (208)
- Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. (1998) (206)
- The Immunomodulatory Effects of Hypertonic Saline Resuscitation in Patients Sustaining Traumatic Hemorrhagic Shock: A Randomized, Controlled, Double-Blinded Trial (2006) (202)
- Tertiary Peritonitis: Clinical Features of a Complex Nosocomial Infection (1993) (199)
- Results of a randomized trial comparing sequential intravenous/oral treatment with ciprofloxacin plus metronidazole to imipenem/cilastatin for intra-abdominal infections. The Intra-Abdominal Infection Study Group. (1996) (196)
- Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity* (2004) (191)
- Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages (2006) (189)
- Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages (1997) (188)
- Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: relevance to laparoscopic surgery. (1997) (184)
- Ertapenem Versus Piperacillin/Tazobactam in the Treatment of Complicated Intraabdominal Infections: Results of a Double-Blind, Randomized Comparative Phase III Trial (2003) (181)
- Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. (2004) (173)
- Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. (2007) (172)
- Definition of the role of enterococcus in intraabdominal infection: analysis of a prospective randomized trial. (1995) (165)
- Prevalence and Causes of Attrition Among Surgical Residents: A Systematic Review and Meta-analysis (2016) (163)
- Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. (2003) (163)
- Comparative Operative Outcomes of Early and Delayed Cholecystectomy for Acute Cholecystitis: A Population-Based Propensity Score Analysis (2014) (161)
- A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages. (1990) (158)
- The IL-1β-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1β (1998) (154)
- v-SNARE-dependent secretion is required for phagocytosis. (1998) (152)
- Osmotic stress-induced remodeling of the cortical cytoskeleton. (2002) (151)
- Regulation of Phagosomal Acidification (1997) (150)
- Soluble Fibrinogen-Like Protein 2/Fibroleukin Exhibits Immunosuppressive Properties: Suppressing T Cell Proliferation and Inhibiting Maturation of Bone Marrow-Derived Dendritic Cells1 (2003) (135)
- Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak". (1991) (131)
- Hypertonic inhibition of exocytosis in neutrophils: central role for osmotic actin skeleton remodeling. (2000) (129)
- A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages (1993) (129)
- Mechanisms of microbial synergy in polymicrobial surgical infections. (1985) (129)
- A Randomized, Double-blind Clinical Trial Comparing Cefepime Plus Metronidazole With Imipenem-Cilastatin in the Treatment of Complicated Intra-abdominal Infections (1997) (128)
- Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide1 (2002) (127)
- Activation of Proton Pumping in Human Neutrophils Occurs by Exocytosis of Vesicles Bearing Vacuolar-type H+-ATPases* (1996) (126)
- Cell Volume-dependent Regulation of L-selectin Shedding in Neutrophils (1999) (125)
- Modeling the two-hit hypothesis for evaluating strategies to prevent organ injury after shock/resuscitation. (2003) (121)
- Succinic acid, a metabolic by-product of Bacteroides species, inhibits polymorphonuclear leukocyte function (1985) (119)
- Cell Shrinkage Regulates Src Kinases and Induces Tyrosine Phosphorylation of Cortactin, Independent of the Osmotic Regulation of Na+/H+ Exchangers* (1999) (111)
- Intestinal bacteria translocate into experimental intra-abdominal abscesses. (1986) (111)
- The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH. (1992) (110)
- Maternal neutrophil apoptosis in normal pregnancy, preeclampsia, and normotensive intrauterine growth restriction. (1999) (107)
- Thiol-mediated redox regulation of neutrophil apoptosis. (1996) (107)
- Management of intra-abdominal infections. The case for intraoperative cultures and comprehensive broad-spectrum antibiotic coverage. The Canadian Intra-abdominal Infection Study Group. (1996) (106)
- Regulation of Cytoplasmic pH in Osteoclasts (1995) (104)
- The Bacteroides by-product succinic acid inhibits neutrophil respiratory burst by reducing intracellular pH (1987) (102)
- Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. (1997) (102)
- Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils. (1997) (100)
- Cell Volume-dependent Phosphorylation of Proteins of the Cortical Cytoskeleton and Cell-Cell Contact Sites (2000) (97)
- Regulation of cytoplasmic pH in phagocytic cell function and dysfunction. (1991) (96)
- Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice. (2004) (96)
- Hyperosmotic stress activates Rho: differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation. (2003) (95)
- N‐ACETYL CYSTEINE ATTENUATES ACUTE LUNG INJURY IN THE RAT (1995) (93)
- A soluble Bacteroides by-product impairs phagocytic killing of Escherichia coli by neutrophils (1989) (91)
- VLA-4 Integrin Cross-linking on Human Monocytic THP-1 Cells Induces Tissue Factor Expression by a Mechanism Involving Mitogen-activated Protein Kinase* (1997) (90)
- Hypertonicity prevents lipopolysaccharide-stimulated CD11b/CD18 expression in human neutrophils in vitro: role for p38 inhibition. (1999) (90)
- GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability. (2009) (88)
- A population-based analysis of the clinical course of 10,304 patients with acute cholecystitis, discharged without cholecystectomy (2013) (84)
- Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome. (2000) (84)
- Granulocytic differentiation of HL‐60 cells results in spontaneous apoptosis mediated by increased caspase expression (1997) (83)
- Postoperative ERAS Interventions Have the Greatest Impact on Optimal Recovery: Experience With Implementation of ERAS Across Multiple Hospitals (2018) (82)
- Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes. (1996) (81)
- Novel strategies for immunomodulation after trauma: revisiting hypertonic saline as a resuscitation strategy for hemorrhagic shock. (2000) (80)
- Twenty-five percent albumin prevents lung injury following shock/resuscitation (2003) (78)
- Dynamic Regulation of Neutrophil Survival through Tyrosine Phosphorylation or Dephosphorylation of Caspase-8* (2008) (77)
- Microbiologic features and treatment of persistent peritonitis in patients in the intensive care unit. (1986) (76)
- Therapeutic options in peritonitis. (1994) (76)
- Stoma closure and wound infection: an evaluation of risk factors. (1995) (75)
- Priming for enhanced alveolar fibrin deposition after hemorrhagic shock: role of tumor necrosis factor. (2000) (73)
- Enhanced Susceptibility to Pulmonary Infection withBurkholderia cepacia inCftr−/− Mice (2001) (71)
- Hypertonic immunomodulation is reversible and accompanied by changes in CD11b expression. (1999) (71)
- Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. (2004) (71)
- Circulating cytokines in predicting development of severe acute pancreatitis (2014) (71)
- Osmotic stress activates Rac and Cdc42 in neutrophils: role in hypertonicity-induced actin polymerization. (2002) (70)
- Hypertonic resuscitation of hemorrhagic shock prevents alveolar macrophage activation by preventing systemic oxidative stress due to gut ischemia/reperfusion. (2005) (70)
- Chronic Extracellular Acidosis Induces Plasmalemmal Vacuolar Type H+ ATPase Activity in Osteoclasts* (1997) (70)
- Relative roles of Na+/H+ exchange and vacuolar‐type H+ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages (1993) (69)
- Fibrin sealant in high-risk colonic anastomoses. (1988) (69)
- Fibrin in peritonitis. V. Fibrin inhibits phagocytic killing of Escherichia coli by human polymorphonuclear leukocytes. (1986) (68)
- Oxidative Stress Reprograms Lipopolysaccharide Signaling via Src Kinase-dependent Pathway in RAW 264.7 Macrophage Cell Line* (2003) (67)
- In vivo and in vitro modulation of intercellular adhesion molecule (ICAM)-1 expression by hypertonicity. (2000) (66)
- Interleukin-1 Increases Vacuolar-type H-ATPase Activity in Murine Peritoneal Macrophages (*) (1996) (66)
- Diagnostic and therapeutic challenges of intraabdominal infections (1990) (63)
- The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. (1998) (62)
- Hypertonic resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by alveolar macrophages. (2003) (61)
- Murine Hepatitis Virus Strain 3 Induces the Macrophage Prothrombinase fgl-2 through p38 Mitogen-activated Protein Kinase Activation* (1998) (60)
- Inequity to the Utilization of Bariatric Surgery: a Systematic Review and Meta-Analysis (2015) (58)
- Results of a Clinical Trial of Clinafloxacin Versus Imipenem/Cilastatin for Intraabdominal Infections (2001) (58)
- Thigh abscess. An uncommon presentation of intraabdominal sepsis. (1986) (57)
- The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro. (1988) (56)
- Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. (2016) (55)
- Pathogenesis of multiple organ dysfunction syndrome: gut origin, protection, and decontamination. (2000) (55)
- Depolarization induces Rho-Rho kinase-mediated myosin light chain phosphorylation in kidney tubular cells. (2005) (55)
- Exploring mentorship as a strategy to build capacity for knowledge translation research and practice: protocol for a qualitative study (2009) (55)
- Cytoplasmic pH regulation in macrophages by an ATP-dependent and N,N'-dicyclohexylcarbodiimide-sensitive mechanism. Possible involvement of a plasma membrane proton pump. (1988) (55)
- V-ATPases in phagocytic cells. (1992) (54)
- Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter? (2005) (54)
- SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus. (2019) (53)
- Pattern of disease after murine hepatitis virus strain 3 infection correlates with macrophage activation and not viral replication (1995) (51)
- Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury: The Role of High Mobility Group-Box 1 (2010) (51)
- Ertapenem Versus Piperacillin/Tazobactam in the Treatment of Complicated Intraabdominal Infections (2003) (50)
- Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury. (1998) (50)
- Cholecystostomy: A bridge to hospital discharge but not delayed cholecystectomy (2013) (50)
- Prevention of endotoxin-induced mortality by antitissue factor immunization. (1996) (50)
- Endotoxin-stimulated alveolar macrophages impair lung epithelial Na+ transport by an L-Arg-dependent mechanism. (1994) (50)
- Posttranscriptional regulation of macrophage tissue factor expression by antioxidants. (1995) (48)
- GPIbα is required for platelet-mediated hepatic thrombopoietin generation. (2018) (48)
- Synergistic induction of IL-10 by hypertonic saline solution and lipopolysaccharides in murine peritoneal macrophages. (2001) (48)
- Impaired apoptotic death signaling in inflammatory lung neutrophils is associated with decreased expression of interleukin-1 beta converting enzyme family proteases (caspases). (1997) (48)
- Role of the Coagulation System in the Local and Systemic Inflammatory Response (1998) (47)
- Inhibition of amiloride-sensitive sodium-channel activity in distal lung epithelial cells by nitric oxide. (1998) (47)
- Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: A role for interleukin 10 (2004) (46)
- Source control review in clinical trials of anti-infective agents in complicated intra-abdominal infections. (2013) (45)
- A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group. (1997) (44)
- Role of fibrin deposition in the pathogenesis of intraabdominal infection (1992) (44)
- FGL2/fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice. (2012) (44)
- Induction of macrophage procoagulant activity by Bacteroides fragilis (1989) (43)
- Redox manipulation using the thiol‐oxidizing agent diethyl maleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model (1999) (40)
- Fibrin in peritonitis. IV. Synergistic intraperitoneal infection caused by Escherichia coli and Bacteroides fragilis within fibrin clots. (1984) (39)
- Antimicrobial therapy for intraabdominal infection. (1996) (39)
- Signaling events in monocytes and macrophages. (1995) (38)
- The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivo. (2004) (38)
- Method for manipulation of cytosolic pH in cells clamped in the whole cell or perforated-patch configurations. (1994) (37)
- The chloride channel blocker 5‐nitro‐2‐(3‐phenylpropyl‐amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells (1991) (37)
- Remote Ischemic Conditioning Prevents Lung and Liver Injury After Hemorrhagic Shock/Resuscitation: Potential Role of a Humoral Plasma Factor. (2015) (37)
- Lethal microbial synergism in intra-abdominal infections. Escherichia coli and Bacteroides fragilis. (1985) (37)
- Interactions between leukocytes and anaerobic bacteria in polymicrobial surgical infections. (1993) (37)
- Impaired antibody production in blunt trauma. Possible role for T cell dysfunction. (1990) (37)
- Diethylmaleate attenuates endotoxin-induced lung injury. (1996) (37)
- Prevention of intra-abdominal abscesses by fibrinolysis using recombinant tissue plasminogen activator. (1988) (36)
- Host response to laparoscopic surgery: mechanisms and clinical correlates. (1998) (35)
- Compliance with Urinary Catheter Removal Guidelines Leads to Improved Outcome in Enhanced Recovery After Surgery Patients (2017) (35)
- Protein kinase C activation accelerates proton extrusion by vacuolar‐type H+‐ATPases in murine peritoneal macrophages (1994) (34)
- The Maternal Syndrome of Preeclampsia: A forme fruste of the Systemic Inflammatory Response Syndrome (2000) (33)
- Modulation of the macrophage respiratory burst by an acidic environment: the critical role of cytoplasmic pH regulation by proton extrusion pumps. (1990) (33)
- Health inequity in access to bariatric surgery: a protocol for a systematic review (2014) (31)
- Emergency Room Visits and Readmissions Following Implementation of an Enhanced Recovery After Surgery (iERAS) Program (2018) (30)
- MAP-kinase dependent induction of monocytic procoagulant activity by beta2-integrins. (1998) (30)
- Mechanisms coordinating gastric and small intestinal MMC: role of extrinsic innervation rather than motilin. (1994) (29)
- Intestinal epithelial cells down-regulate macrophage tumor necrosis factor-alpha secretion: a mechanism for immune homeostasis in the gut-associated lymphoid tissue. (1995) (28)
- Percutaneous aspiration and drainage for suspected abdominal infection. (1984) (28)
- Nitric oxide derived from L-arginine impairs cytoplasmic pH regulation by vacuolar-type H+ ATPases in peritoneal macrophages (1991) (28)
- Monocyte Adhesion and Transmigration Induce Tissue Factor Expression: Role of the Mitogen-Activated Protein Kinases (2002) (27)
- Differential stimulation of macrophage procoagulant activity by vascular grafts. (1993) (27)
- Integrin engagement induces monocyte procoagulant activity and tumor necrosis factor production via induction of tyrosine phosphorylation. (1996) (27)
- Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway. (2003) (26)
- Mechanism of the adjuvant effect of hemoglobin in experimental peritonitis: VIII. A leukotoxin is produced by Escherichia coli metabolism in hemoglobin. (1984) (26)
- Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practice. (2013) (25)
- 25% Albumin modulates adhesive interactions between neutrophils and the endothelium following shock/resuscitation. (2002) (25)
- Reciprocal synergy between Escherichia coli and Bacteroides fragilis in an intra-abdominal infection model. (1989) (24)
- Delayed administration of tissue plasminogen activator reduces intra-abdominal abscess formation. (1989) (24)
- IMPAIRED INDUCTION OF IL-10 EXPRESSION IN THE LUNG FOLLOWING HEMORRHAGIC SHOCK (2004) (24)
- Enteric duplication in the adult, derived from the foregut, midgut and hindgut: presentation, patterns and literature review. (1997) (24)
- Are clinician-scientists an endangered species? Barriers to clinician-scientist training. (2002) (23)
- Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets. (2017) (22)
- Preventing Endotoxin-Stimulated Alveolar Macrophages from Decreasing Epithelium Na+ Channel (ENaC) mRNA Levels and Activity (2000) (22)
- Disparate mechanisms of induction of procoagulant activity by live and inactivated bacteria and viruses (1990) (22)
- Bacterial translocation induces procoagulant activity in tissue macrophages. A potential mechanism for end-organ dysfunction. (1991) (22)
- Profibrotic epithelial phenotype: a central role for MRTF and TAZ (2019) (22)
- "I've never asked one question." Understanding the barriers among orthopedic surgery residents to screening female patients for intimate partner violence. (2014) (21)
- Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation (2015) (21)
- Early Cholecystectomy for Acute Cholecystitis Offers the Best Outcomes at the Least Cost: A Model-Based Cost-Utility Analysis. (2016) (21)
- Peritoneal host defenses: modulation by carbon dioxide insufflation. (2001) (21)
- Enhanced recovery after vascular surgery: protocol for a systematic review (2012) (21)
- Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections. (2017) (20)
- Regulation of cytoplasmic pH in resident and activated peritoneal macrophages. (1990) (20)
- The spectrum of Escherichia coli--Bacteroides fragilis pathogenic synergy in an intraabdominal infection model. (1988) (20)
- Chapter 10 Regulation and Functional Significance of Cytoplasmic pH in Phagocytic Leukocytes (1990) (19)
- The development of a novel intracolonic occlusion balloon for transcolonic natural orifice transluminal endoscopic surgery: description of the technique and early experience in a porcine model (with videos). (2008) (19)
- Cytoplasmic pH regulation in monocytes and macrophages: mechanisms and functional implications. (1991) (19)
- Indirect Role for COPI in the Completion of Fcγ Receptor-mediated Phagocytosis* (2001) (19)
- Improved lung preservation with dextran 40 is not mediated by a superoxide radical scavenging mechanism. (1992) (18)
- Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis. (2005) (18)
- Neuroanatomical correlates of laparoscopic surgery training (2014) (18)
- Cancer patient experience with navigation service in an urban hospital setting: a qualitative study. (2016) (18)
- Control of cytoplasmic pH by Na+/H+ exchange in rat peritoneal macrophages activated with phorbol ester (1987) (18)
- Platelet-activating factor primes endotoxin-stimulated macrophage procoagulant activity. (1991) (17)
- Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries (2015) (17)
- Exudative neutrophils show impaired pH regulation compared with circulating neutrophils. (1996) (17)
- Portal endotoxemia stimulates the release of an immunosuppressive factor from alveolar and splenic macrophages. (1993) (16)
- Intracellular pH regulation in leukocytes: mechanisms and functional significance. (1996) (16)
- Gastropleural fistula. Report of three cases and review of the literature. (1985) (16)
- Platelet-activating factor modulates endotoxin-induced macrophage procoagulant activity by a protein kinase C-dependent mechanism (1992) (16)
- Fatty acid binding protein 3 is associated with peripheral arterial disease (2020) (16)
- Gastrointestinal phytobezoars: presentation and management. (1986) (15)
- The IL-1b-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1 b (1998) (15)
- Anatomical, physiological, and logistical indications for the open abdomen: a proposal for a new classification system (2016) (15)
- Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection. (2008) (15)
- Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8. (2014) (15)
- pH-dependent impairment of the neutrophil respiratory burst by the Bacteroides byproduct succinate. (1988) (15)
- Hemorrhagic Shock/Resuscitation Reduces the M2 Phenotype of Alveolar Macrophages: A Potential Mechanism Contributing to Increased LPS-Induced Lung Injury (2019) (15)
- Tissue plasminogen activator reverses the deleterious effect of infection on colonic wound healing. (1990) (14)
- Mechanism of the adjuvant effect of hemoglobin in experimental peritonitis. IX: The infection-potentiating effect of hemoglobin in Escherichia coli peritonitis is strain specific. (1985) (14)
- Tricuspid valve Candida endocarditis. Successful treatment with valve-sparing debridement and antifungal chemotherapy in a multiorgan transplant recipient. (1986) (14)
- Toward late career transitioning: a proposal for academic surgeons. (2017) (14)
- Lipopolysaccharide impairs macrophage cytoplasmic pH regulation under conditions simulating the inflammatory microenvironment (1992) (14)
- A Bacteroides by-product inhibits human polymorphonuclear leukocyte function. (1986) (14)
- Oxidants and antioxidant therapy. (2001) (13)
- Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis. (2001) (13)
- Stilbazulenyl nitrone decreases oxidative stress and reduces lung injury after hemorrhagic shock/resuscitation and LPS. (2007) (13)
- ndufa7 plays a critical role in cardiac hypertrophy (2020) (13)
- Mechanisms of cytoplasmic pH recovery in acid-loaded macrophages. (1989) (13)
- Succinic acid production by Bacteroides fragilis. A potential bacterial virulence factor. (1987) (13)
- The Immunological Effects of Hypertonic Saline (2002) (13)
- Delayed treatment with diethyl maleate prevents E-selectin expression in human endothelial cells. (1999) (12)
- Does Isolation of Enterococcus Affect Outcomes in Intra-Abdominal Infections? (2017) (12)
- The role of Bacteroides encapsulation in the lethal synergy between Escherichia coli and Bacteroides species studied in a rat fibrin clot peritonitis model. (1987) (11)
- Unilamellar liposomes modulate secretion of tumor necrosis factor by lipopolysaccharide-stimulated macrophages (1994) (11)
- Inhibition of amiloride-sensitive sodium-channel activity in distal lung epithelial cells by nitric oxide. (1998) (11)
- Abdominal catastrophes in the intensive care unit setting. (2013) (11)
- The Role of Coagulation in Systemic Inflammation: A Review of the Experimental Evidence (1998) (11)
- Three Sequential Balloon Catheters for Vascular Exclusion of the Liver and Aortic Control (one REBOA and two REBOVCs): A Hemorrhage Control Strategy in Suprahepatic Vena Cava Injuries (2018) (11)
- The cost-effectiveness of cefepime plus metronidazole versus imipenem/cilastatin in the treatment of complicated intra-abdominal infection. (2004) (11)
- Bioavailability of oral ciprofloxacin in early postsurgical patients. (1998) (11)
- Prevention of intra-abdominal abscesses with fibrinolytic agents. (1988) (11)
- Altered Inhibitory &kgr;B Alpha Expression in LPS-Stimulated Alveolar Macrophages Following Resuscitated Hemorrhagic Shock (2011) (11)
- Percutaneously drained intra-abdominal infections do not require longer duration of antimicrobial therapy (2016) (11)
- The glutathione depleting agent diethylmaleate prolongs renal allograft survival. (1998) (10)
- Antioxidants increase lipopolysaccharide-stimulated TNFα release in murine macrophages: Role for altered TNFα mRNA stability (2001) (10)
- Decreased leukocyte adhesion with anti-CD18 monoclonal antibodies is mediated by receptor internalization. (1992) (10)
- Mast cell modulation of macrophage procoagulant activity and TNF production. (1995) (10)
- Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock. (2019) (10)
- Bone matrix proteins and extracellular acidification: Potential co‐regulators of osteoclast morphology (2010) (9)
- Phagosomal acidification mechanisms and functional significance (1999) (9)
- A Gastrointestinal Stromal Tumor Presenting as an Ovarian Tumor (2007) (9)
- Vapourized hydrogen peroxide decontamination in a hospital setting inactivates SARS-CoV-2 and HCoV-229E without compromising filtration efficiency of unexpired N95 respirators (2021) (9)
- Production But Inhibits Th2 Cytokine Response Prothrombinase and Preserves Th1 Cytokine Production of TNF, IL-1, the Procoagulant fgl2 Ribavirin Inhibits Viral-Induced Macrophage (1998) (9)
- Vascular Risk Reduction in Obesity through Reduced Granulocyte Burden and Improved Angiogenic Monocyte Content following Bariatric Surgery (2020) (8)
- In-vivo bactericidal activity of Sch 34343 in Bacteroides fragilis abscesses and in Bacteroides fragilis-Escherichia coli abscesses. (1985) (8)
- Small bowel obstruction due to intestinal migration of an inferior vena cava polytetrafluoroethylene graft. (2002) (8)
- Patients with Risk Factors for Complications Do Not Require Longer Antimicrobial Therapy for Complicated Intra-Abdominal Infection (2016) (8)
- “No scar” small bowel resection in a survival porcine model using transcolonic NOTES® and transabdominal approach (2011) (8)
- Mediastinitis after whiplash injury. (1986) (7)
- Yersinia enterocolitica as a cause of intra-abdominal abscess: the role of iron. (2001) (7)
- Age and Its Impact on Outcomes with Intra-Abdominal Infection. (2017) (7)
- Transmission of aerosols through pristine and reprocessed N95 respirators (2020) (7)
- The role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages (1997) (7)
- Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation (1995) (6)
- Intracellular pH regulation in neutrophils: properties and distribution of the Na+/H+ antiporter. (1988) (6)
- Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease? (2021) (6)
- A Graduate Student Oath (2008) (6)
- Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis‐independent NF‐κB activation (2015) (6)
- Antioxidant therapy in critical illness. (2004) (6)
- Oxidant stress inhibits pH regulatory mechanisms in murine peritoneal macrophages. (1994) (6)
- GEF-H1 Mediates Tumor Necrosis Factor-α-induced Rho Activation and Myosin Phosphorylation (2009) (6)
- Impaired activation of mitogen-activated protein kinases after hemorrhagic shock. (2002) (6)
- Physiologic human T-cell responses to OKT3 in the human peripheral blood lymphocyte-severe combined immunodeficiency mouse model. (1997) (5)
- Antioxidant modulation of skin inflammation: preventing inflammatory progression by inhibiting neutrophil influx. (1999) (5)
- Does the size of the stitch length affect surgical site infection? (2013) (5)
- Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients (2020) (5)
- Non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease. (2022) (5)
- Assessment of coagulation in surgical critical care patients (2001) (5)
- Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability. (2001) (5)
- Na+/H+ exchange and the regulation of intracellular pH in polymorphonuclear leukocytes. (1988) (5)
- Signaling Pathways of Tissue Factor Expression in Monocytes and Macrophages (1999) (5)
- Mechanisms of leukocyte activation (1990) (5)
- Wound infection during stoma closure. (1995) (5)
- Glutathione depletion of stimulator cells inhibits responder T-cell immunogenicity in vitro and prolongs allograft survival in vivo. (2006) (4)
- Humanistic education in surgery: a "patient as teacher" program for surgical clerkship. (2020) (4)
- Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection. (1998) (4)
- Exploring the past, charting the future. (1997) (4)
- Management of infection in the surgical patient: an update. (2003) (4)
- Inflammation Following Lipopolysaccharide Chemoattractant in the Lung: Role in Pulmonary Expression of Cytokine-Induced Neutrophil Hemorrhagic Shock Primes for Increased (1998) (4)
- Patients with Risk Factors for Complications Do Not Require Longer Antimicrobial Therapy for Complicated Intra-Abdominal Infection. (2016) (3)
- [TLR4 is involved in hepatic ischemia/reperfusion injury in mice]. (2003) (3)
- Mead Johnson Critical Care Symposium for the Practising Surgeon. 5. The diagnosis and management of common soft-tissue infections. (1988) (3)
- Selective decontamination of the digestive tract in acute severe pancreatitis--an indication whose time has come. (1997) (3)
- Perceived Challenges to Routine Uptake of the Ankle Brachial Index within Primary Care Practice (2021) (3)
- Embryonic-Derived Myb− Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis (2021) (3)
- Modulation of macrophage procoagulant activity by arachidonic acid metabolites. (1992) (3)
- An Overview of Intracellular pH Regulation: Role of Vacuolar H+-ATPases (1995) (3)
- Reevaluation of the 'instant' colon preparation with povidone- iodine (1985) (2)
- Effect of alterations in early signal transduction events on the induction of procoagulant activity by murine hepatitis virus strain 3 in vitro. (1995) (2)
- The Maternal Syndrome of Preeclampsia: A forme (2000) (2)
- Prevalence and Causes of Attrition Among Surgical Residents: A Systemic Review and Meta-Analysis (2016) (2)
- S1576: A Pilot Study in a Survival Porcine Model Evaluating the Feasibility and Safety of Adhesiolysis by Using Transgastric NOTES® Approach, Waterjet Technology and Endoscopic Instruments (2010) (2)
- Early cellular events in the induction of murine hepatitis virus (MHV-3) induced macrophage procoagulant activity (PCA). (1993) (2)
- Antimicrobial agents for the prevention and treatment of abdominal infections: a new generation? (1998) (2)
- Management of pyogenic liver abscess in the era of computed tomography. (1990) (1)
- Emergency Room Visits and Readmissions Following Implementation of an Enhanced Recovery after Surgery (ERAS) Program (2017) (1)
- Validating fatty acid binding protein 3 as a diagnostic and prognostic biomarker for peripheral arterial disease: A three-year prospective follow-up study (2022) (1)
- Management of Infection in the Surgical Patient. (2000) (1)
- Reoperation After Source Control Surgery for Intra-abdominal Infection (2003) (1)
- STOP Signs: A Population-based Interrupted Time Series Analysis of Antibiotic Duration for Complicated Intraabdominal Infection Before and After the Publication of a Landmark RCT (2021) (1)
- Burnout and Career Satisfaction Among Canadian Vascular Surgeons (2020) (1)
- Hypertonicity induces shedding of L-selectin: a role for p38 activation (2000) (1)
- Fibrin inhibits phagocytosis and killing of Escherichia coli by polymorphonuclear leukocytes (1984) (1)
- Re-establishing continuity after the Hartmann's procedure using the EEA stapler. (1984) (1)
- Laparoscopic Splenectomy for Resistant Immune Thrombocytopenia in Pregnancy- A Case Report and Review of Literature (2018) (1)
- 93 – How to Review a Manuscript (2001) (1)
- Modified triple-layer peritoneal-aponeurotic transposition: A new strategy to close the "open abdomen". (2015) (1)
- Intra-abdominal Infection (2005) (1)
- Performance of Experimental Occlusion Balloon in Transcolonic Endoscopic Peritoneoscopy (NOTES) (2008) (0)
- Neutrophil apoptosis in normal pregnancy and preeclampsia (1998) (0)
- Engaging Clinicians: Ontario's General Surgeons Develop a Multidisciplinary Approach for Prioritizing Patients Using the Electronic Wait Time Information System (2007) (0)
- Fer kinase is a novel regulator of Jak/STAT signaling pathway (2006) (0)
- Oxidant-induced Akt phosphorylation in murine macrophages involves ceramide generation through the acid sphingomyelinase pathway (2006) (0)
- Étude de cas ENTERIC DUPLICATION IN THE ADULT , DERIVED FROM THE FOREGUT , MIDGUT AND HINDGUT : PRESENTATION , PATTERNS AND LITERATURE REVIEW (2014) (0)
- Compliance with enhanced recovery after surgery (ERAS) pathways improves outcome in patients undergoing both open and laparoscopic colorectal procedures (2017) (0)
- The Role of Macrophage Procoagulants in Infection (2019) (0)
- Oxidant-induced Akt phosphorylation in murine macrophages requires generation of ceramide metabolites through sphingosine kinase (2007) (0)
- The adjuvant effect of bile salts in experimental peritonitis (1984) (0)
- Hypertonic Saline Resuscitation of Posttraumatic Hemorrhagic Shock Patients Promotes Inflammatory Cytokine Equilibrium: 459 (2004) (0)
- Mini-oral session: Fri 2/15 4:00 pmTrauma/critical care VII: Sepsis and signaling IQS377. Oxidant-Induced Activation of ERK in RAW 264.7 Macrophages Is Mediated by Sphingosine-1-Phosphate (2008) (0)
- Hypertonic Preconditioning Alters the Balance of Pro- and Anti-Inflammatory Cytokines in Hepatic Ischemia/Reperfusion: 27 (2000) (0)
- “No Scar” Small Bowel Resection Using Transcolonic NOTES® & Transabdominal Approach (2009) (0)
- Burnout and Career Satisfaction amongst Academic Surgeons in a Large University Department of Surgery (2020) (0)
- Stilbazulenyl nitrone (STAZN), a novel azulenyl nitrone antioxidant prevents lung injury following hemorrhagic shock and alters TLR4 distribution in alveolar macrophages (2004) (0)
- Pyrrolidine dithiocarbamate (PDTC) increases TNF-α mRNA stability (1996) (0)
- Attenuation of pancreatitis-induced pulmonary injury by aerosolised hypertonic saline (2001) (0)
- HEMORRHAGIC SHOCK PRIMES FOR ALVEOLAR FIBRIN DEPOSITION.: 231 (1998) (0)
- The 57th Volume of the Surgical Forum is dedicated to Jonathan L Meakins, MD, FACS (2006) (0)
- Abstract 11527: Prolonged Cardiovascular System Failure in South Asians Undergoing Cardiopulmonary Bypass Correlates with Prolonged Inflammation and Increased TLR4-Mediated Signaling (2011) (0)
- Cell volume-dependent phosphorylation and reorganization of elements of the cortical cytoskeleton and the cell-cell contacts (2000) (0)
- EFFECT OF BLUNT TRAUMA ON T LYMPHOCYTE ACTIVITY (1989) (0)
- Letter to the editor: Concomitant resuscitative endovascular balloon occlusion of the aorta and the inferior vena cava. (2020) (0)
- Prevention of acute lung injury using a sulfhydryl agent (2005) (0)
- Management of infection in the surgical patient. (2000) (0)
- Effect of lignin (LIG) and lactulose (LAC) on bile composition in hamsters receiving ethinyl estradiol (EE) (1980) (0)
- Surgical approach #1 to severe necrotizing pancreatitis (1999) (0)
- Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fc (cid:103) Receptors in Macrophages (1997) (0)
- OXIDANTS IN HEMORRHAGIC SHOCK INDUCE LIPID RAFT RECRUITMENT OF TOLL LIKE RECEPTOR‐4 (TLR‐4).: 73 (2003) (0)
- GLUTATHIONE DEPLETION OF STIMULATOR CELLS INHIBITS RESPONDER T-CELL ALLOREACTIVITY (1999) (0)
- MONOCYTE ADHERENCE TO AN ACTIVATED ENDOTHELIAL SURFACE INDUCES MAP KINASE TYROSINE PHOSPHORYLATION: 223 (1998) (0)
- RESTORATION OF INFLAMMATORY CYTOKINE BALANCE BY SMALL-VOLUME HYPERTONIC SALINE RESUCITATION IN HEMORRHAGIC SHOCK TRAUMA PATIENTS (2004) (0)
- genuine damage control laparotomy in peritonitis a twenty year review (2017) (0)
- Reply to: "Early Cholecystectomy for Acute Cholecystitis, How Early Should It Be?". (2016) (0)
- Hypertonic Saline Resuscitation Modulates Neutrophil Adhesion Molecule Expression of Post-Traumatic Hemorrhagic Shock Patients (2004) (0)
- LIPID RAFT RECRUITMENT OF TOLL LIKE RECEPTOR‐4 (TLR4) IS NECESSARY FOR OXIDANAT INDUCED NFKAPPAB TRANSLOCATION IN MACROPHAGES.: 78 (2004) (0)
- 586 Compliance With Removal of Urinary Catheter Guideline Recommendations Leads to Improved Outcome in Enhanced Recovery After Surgery (ERAS) Patients (2016) (0)
- Oxidant-induced TLR4 translocation in murine macrophages is Src kinase dependent (2007) (0)
- Hypocholesterolemic effect of dietary fiber and lactulose (1981) (0)
- LYMPHOCYTE-MEDIATED DENDRITIC CELL TYROSINE PHOSPHORYLATION AND MAP KINASE ACTIVATION CONTRIBUTE TO ALLOGENEIC RESPONSES IN VITRO (1999) (0)
- MODULATION OF LOCAL INFLAMMATION BY ANTIOXIDANTS: 220 (1996) (0)
- physiological implications (ERM) proteins: activation mechanisms and Osmotic cell shrinkage activates ezrin/radixin/moesin (2009) (0)
- Remote ischemic preconditioning prevents liver injury in a murine model of hemorrhagic shock/resuscitation (2013) (0)
- Hemorrhagic Shock and Lipopolysaccharide Expression in the Lung Following Regulation of Toll-Like Receptor 4 (2002) (0)
- A Murine Model Of Hemorrhagic Shock/Resuscitation Demonstrates Transfusion Related Acute Lung Injury (TRALI) Induced By Stored Platelet Transfusions (2013) (0)
- History of the Department of Surgery at the University of Toronto: celebrating a centennial of progress and innovation (2022) (0)
- Hemorrhagic Shock Modulates Toll-Like Receptor-4 (TLR4) Expression in Response to LPS: 19 (2000) (0)
- Characterizing the Impact of Procedure Funding on the Covid-19 Generated Procedure Gap in Ontario: A Population-Based Analysis. (2022) (0)
- HYPERTONICITY ATTENUATES STIMULATED MACROPHAGE RESPONSES (1999) (0)
- Featured Articles for CME Credit July 2016. (2016) (0)
- Dr. Bernard Langer - inductee into the Canadian Medical Hall of Fame. (2015) (0)
- Time to adjuvant chemotherapy (TTAC) after open or laparoscopic resection surgeries in colorectal cancers (CRC). (2015) (0)
- FGL2/FIBROLEUKIN MEDIATES HEPATIC REPERFUSION INJURY BY INDUCTION OF SINUSOIDAL ENDOTHELIAL CELL APOPTOSIS IN MICE: 758 (2010) (0)
- Marrow-Derived Dendritic Cells and Inhibiting Maturation of Bone Properties : Suppressing T Cell Proliferation 2 / Fibroleukin Exhibits Immunosuppressive Soluble Fibrinogen-Like Protein and (2003) (0)
- A Clinical Approach to Antioxidant Therapy: Hypertonic Fluid Resuscitation Trial (2003) (0)
- 100 Prolonged cardiovascular system failure in South Asians undergoing cardiopulmonary bypass correlates with prolonged inflammation and increased TLR4-mediated signaling (2011) (0)
- Hypertonic Saline Resuscitation Restores Inflammatory Cytokine Balance in Post-Traumatic Hemorrhagic Shock Patients (2004) (0)
- The Clinician with a Basic Science Laboratory (1998) (0)
- Did We STOP-IT? a Population-Based Interrupted Time Series Analysis of Antimicrobial Duration for Intra-abdominal Infections Before and after the Publication of a Landmark Randomized Controlled Trial (2021) (0)
- ACTIVATED NEUTROPHILS DEMONSTRATE THIOL‐DEPENDENT RESISTANCE TO FAS TRIGGERED APOPTOTIC SIGNALS: 464 (1997) (0)
- 2076 Evaluating carcinoembryonic antigen as a predictor and surveillance marker for colorectal cancer recurrence (2015) (0)
- Hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages: A novel mechanism of cell priming for LPS signaling (2005) (0)
- QS375. The Role of p38 in Fer Kinase Dependent Regulation of the Jak/STAT Pathway (2008) (0)
- HYPERIONICITY INHIBITS THE ACTIVATION OF p38 MAPK IN NEUIROPHILS (1998) (0)
- Lipopolysaccharide signaling pathways and their role in the development of the systemic inflammatory response syndrome (1999) (0)
- Hydrogen-enriched lactated Ringer solution enhances endogenous superoxide dismutase activity: protection against damage from reactive oxigen species (2017) (0)
- Circulating Neutrophils from Trauma Patients Induce Apoptosis Through Dephosphorylation of Epithelial Cell Caspase-8 (2011) (0)
- OXIDANT‐INDUCED PRIMING OF THE MACROPHAGE INVOLVES TYROSINE PHOSPHORYLATION OF IKK VIA A SRC KINASE PATHWAY: 164 (2004) (0)
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