Otto G. Berg
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Otto G. Bergbiology Degrees
Biology
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#14917
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Evolutionary Biology
#271
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#293
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Microbiology
#656
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#725
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Neuroscience
#1871
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#1927
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Biology
Otto G. Berg's Degrees
- PhD Microbiology Stanford University
- Masters Biology Stanford University
- Bachelors Biology Stanford University
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Why Is Otto G. Berg Influential?
(Suggest an Edit or Addition)Otto G. Berg's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Selection of Resistant Bacteria at Very Low Antibiotic Concentrations (2011) (1267)
- Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory. (1981) (1142)
- Facilitated target location in biological systems. (1989) (891)
- Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters. (1987) (720)
- Diffusion-controlled macromolecular interactions. (1985) (649)
- Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The Escherichia coli lac repressor--operator interaction: kinetic measurements and conclusions. (1981) (523)
- Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. (2000) (442)
- Horizontal gene transfer: A critical view (2003) (418)
- Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. (2000) (402)
- Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori (2001) (390)
- The lac Repressor Displays Facilitated Diffusion in Living Cells (2012) (367)
- A model for the statistical fluctuations of protein numbers in a microbial population. (1978) (290)
- On the specificity of DNA-protein interactions. (1986) (283)
- Selection of DNA binding sites by regulatory proteins. II. The binding specificity of cyclic AMP receptor protein to recognition sites. (1988) (273)
- Interfacial enzymology: the secreted phospholipase A(2)-paradigm. (2001) (265)
- Evolution of high-level resistance during low-level antibiotic exposure (2018) (262)
- Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium (2002) (241)
- The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting. (1989) (234)
- Biological Costs and Mechanisms of Fosfomycin Resistance in Escherichia coli (2003) (223)
- Selection of DNA binding sites by regulatory proteins. (1988) (212)
- Effects of macromolecular crowding and DNA looping on gene regulation kinetics (2009) (208)
- Selection-Driven Gene Loss in Bacteria (2012) (198)
- Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2. (1995) (191)
- Genomic buffering mitigates the effects of deleterious mutations in bacteria (2005) (167)
- Evolution of microbial genomes: sequence acquisition and loss. (2002) (139)
- Association kinetics with coupled diffusional flows. Special application to the lac repressor--operator system. (1976) (138)
- Interfacial catalysis by phospholipase A2: determination of the interfacial kinetic rate constants. (1991) (133)
- Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes. (2006) (130)
- Stochastic reaction-diffusion kinetics in the microscopic limit (2010) (129)
- Why mitochondrial genes are most often found in nuclei. (2000) (124)
- Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated. (2000) (117)
- On diffusion-controlled dissociation (1978) (113)
- Growth rate-optimised tRNA abundance and codon usage. (1997) (112)
- Near-critical phenomena in intracellular metabolite pools. (2003) (111)
- How do genome-regulatory proteins locate their DNA target sites? (1982) (107)
- Mutational Robustness of Ribosomal Protein Genes (2010) (102)
- Contribution of Gene Amplification to Evolution of Increased Antibiotic Resistance in Salmonella typhimurium (2009) (102)
- The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2. (1993) (100)
- Orientation constraints in diffusion-limited macromolecular association. The role of surface diffusion as a rate-enhancing mechanism. (1985) (98)
- On the nature of gene innovation: duplication patterns in microbial genomes. (2003) (95)
- Inhibition of phospholipase A2 (1994) (93)
- Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid. (1998) (92)
- Interfacial catalysis by phospholipase A2: substrate specificity in vesicles. (1991) (89)
- Interfacial catalysis by phospholipase A2: dissociation constants for calcium, substrate, products, and competitive inhibitors. (1991) (88)
- Compensatory gene amplification restores fitness after inter‐species gene replacements (2010) (85)
- The influence of macromolecular crowding on thermodynamic activity: Solubility and dimerization constants for spherical and dumbbell‐shaped molecules in a hard‐sphere mixture (1990) (83)
- Experimental Adaptation of Salmonella typhimurium to Mice (2004) (79)
- Codon bias in Escherichia coli: the influence of codon context on mutation and selection. (1997) (78)
- Transcription-factor binding and sliding on DNA studied using micro- and macroscopic models (2013) (75)
- Kinetic basis for interfacial catalysis by phospholipase A2. (1995) (73)
- High fitness costs and instability of gene duplications reduce rates of evolution of new genes by duplication-divergence mechanisms. (2014) (71)
- Selection of DNA binding sites by regulatory proteins: the LexA protein and the arginine repressor use different strategies for functional specificity. (1988) (68)
- Association kinetics with coupled diffusion III. Ionic-strength dependence of the lac repressor-operator association. (1978) (66)
- Gradients in nucleotide and codon usage along Escherichia coli genes. (2000) (65)
- Interfacial Enzymology: The Secreted Phospholipase A2‐Paradigm (2001) (64)
- Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipids. (1996) (62)
- Regulating general mutation rates: examination of the hypermutable state model for Cairnsian adaptive mutation. (2003) (61)
- Duplication is more common among laterally transferred genes than among indigenous genes (2003) (58)
- Selection intensity for codon bias and the effective population size of Escherichia coli. (1996) (58)
- Interfacial Enzyme Kinetics (2002) (57)
- Interfacial catalysis by phospholipase A2: activation by substrate replenishment. (1991) (55)
- Association kinetics with coupled diffusion. An extension to coiled-chain macromolecules applied to the lac repressor-operator system. (1977) (54)
- Detection of Genes with Atypical Nucleotide Sequence in Microbial Genomes (2002) (49)
- Association kinetics with coupled three- and one-dimensional diffusion. Chain-length dependence of the association rate of specific DNA sites. (1982) (49)
- Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2. (2000) (47)
- Lost in presumption: stochastic reactions in spatial models (2012) (45)
- Evolution of new gene functions: simulation and analysis of the amplification model (2009) (44)
- Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces. (1997) (43)
- Muller’s ratchet in symbiont populations (2007) (41)
- What matters for lac repressor search in vivo—sliding, hopping, intersegment transfer, crowding on DNA or recognition? (2015) (40)
- Fluctuations in repressor control: thermodynamic constraints on stochastic focusing. (2000) (39)
- The origins of modern proteomes. (2007) (38)
- The Amplification Model for Adaptive Mutation (2005) (36)
- Coupling of the i-face and the active site of phospholipase A2 for interfacial activation. (2006) (36)
- DNA surface exploration and operator bypassing during target search (2020) (32)
- Synonymous substitution-rate constants in Escherichia coli and Salmonella typhimurium and their relationship to gene expression and selection pressure (1995) (29)
- Brownian motion of the wormlike chain and segmental diffusion of DNA (1979) (29)
- Relationship of interfacial equilibria to interfacial activation of phospholipase A2. (1993) (28)
- Direct vesicle-vesicle exchange of phospholipids mediated by polymyxin B. (1995) (28)
- Diffusion‐controlled protein–DNA association: Influence of segemental diffusion of the DNA (1984) (27)
- Comparison of repressor and transcriptional attenuator systems for control of amino acid biosynthetic operons. (2001) (27)
- Mutational Interference and the Progression of Muller's Ratchet When Mutations Have a Broad Range of Deleterious Effects (2007) (24)
- The chemical step is not rate-limiting during the hydrolysis by phospholipase A2 of mixed micelles of phospholipid and detergent. (1993) (24)
- Periodic selection and hitchhiking in a bacterial population. (1995) (24)
- Eclipse period without sequestration in Escherichia coli (2002) (24)
- Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2. (1997) (23)
- Interfacial enzymology of phospholipase A2 (1992) (23)
- Assay of phospholipases A2 and their inhibitors by kinetic analysis in the scooting mode (1992) (22)
- Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia. (2009) (21)
- Mass action relations in vivo with application to the lac operon. (1977) (20)
- Variation in Mutational Robustness between Different Proteins and the Predictability of Fitness Effects. (2016) (20)
- Gene Import or Deletion: A Study of the Different Genes in Escherichia coli Strains K12 and O157:H7 (2002) (19)
- Phosphatidylinositol-specific phospholipase C forms different complexes with monodisperse and micellar phosphatidylcholine. (2004) (18)
- Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. (2002) (18)
- Cooperative binding of monodisperse anionic amphiphiles to the i-face: phospholipase A2-paradigm for interfacial binding. (2004) (16)
- Synonymous Nucleotide Divergence and Saturation: Effects of Site-Specific Variations in Codon Bias and Mutation Rates (1999) (15)
- Kick-Starting the Ratchet: The Fate of Mutators in an Asexual Population (2011) (15)
- Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2. (1998) (15)
- Effective diffusion rate through a polymer network: Influence of nonspecific binding and intersegment transfer (1986) (14)
- Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles. (1999) (14)
- Mesoscopic kinetics and its applications in protein synthesis (2005) (13)
- Deletion rate evolution and its effect on genome size and coding density. (2009) (13)
- Selection of DNA binding sites by regulatory proteins. Functional specificity and pseudosite competition. (1988) (13)
- Quantification of transcription factor-DNA binding affinity in a living cell (2015) (13)
- Residual human immunodeficiency virus type 1 infection in lymphoid tissue during highly active antiretroviral therapy: quantitation and virus characterization. (2001) (12)
- On the specificity of DNA-protein interactions (regulation of transcription/DNA binding site specification/recognition mechanisms/regulatory proteins/lac repressor) (2016) (12)
- Origins of delays in monolayer kinetics: phospholipase A2 paradigm. (2004) (12)
- The evolutionary selection of DNA base pairs in gene-regulatory binding sites. (1992) (11)
- On the origin of lag phase in monolayer enzymology (2000) (11)
- Contiguous binding of decylsulfate on the interface-binding surface of pancreatic phospholipase A2. (2008) (11)
- DNA-protein interactions in the regulation of gene expression (1989) (10)
- Role of 57-72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A(2): regulation of fat and cholesterol homeostasis. (2007) (10)
- Eclipse period during replication of plasmid R1: contributions from structural events and from the copy‐number control system (2003) (9)
- Microscopic diffusion-reaction coupling in steady-state enzyme kinetics. (1983) (7)
- Quantitative and structural analysis of inhibitors of phospholipase A2 (1991) (7)
- Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover. (2005) (6)
- Adaptive Mutation Requires No Mutagenesis—Only Growth Under Selection: A Response (2003) (6)
- Mutation frequency and biological cost of resistance in Helicobacter pylori. (2001) (6)
- Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2. (2009) (6)
- The helical structure of DNA facilitates binding (2016) (5)
- Base-pair specificity of protein-DNA recognition: a statistical-mechanical model. (1990) (4)
- Taking the reaction-diffusion master equation to the microscopic limit (2009) (3)
- DNA surface exploration and operator bypassing during target search (2020) (3)
- Kinetics of synonymous codon change for an amino acid of arbitrary degeneracy (1995) (3)
- On the Nature and Specificity of DNA-Protein Interactions in the Regulation of Gene Expression (1987) (3)
- Allosteric effect of amphiphile binding to phospholipase A(2). (2009) (3)
- A Hitchhiker's Guide to Evolving Networks (2010) (2)
- Statistical ensembles for sequence variability (1987) (1)
- Principles of Inhibition of Phospholipase A2 and Other Interfacial Enzymes (1997) (1)
- Surface diffusion as a rate-enhancing mechanism in macromolecular association: The effectiveness of one- and two-dimensional surface sliding (1988) (1)
- Diffusion properties of active particles with directional reversal (2016) (1)
- Evolution of high-level resistance during low-level antibiotic exposure (2018) (0)
- Kinetics of synonymous codon change for an amino acid of arbitrary degeneracy (2004) (0)
- Nucleic acids and molecular biology, vol. 1: edited by F. Eckstein and D. M. J. Lilley, Springer-Verlag, 1987. DM 148.00 (x + 243 pages) ISBN 3 540 17595 4 (1988) (0)
- Replication of Plasmid R1 during Downshift in Copy number. (2003) (0)
- Physical modeling is increasingly important for generating insights into intracellular processes. We describe situations in which combined spatial and stochastic aspects of chemical reactions are needed to capture the relevant dynamics of biochemical systems. (2012) (0)
- Target Location by DNA-Binding Proteins: Effects of Roadblocks and DNA Looping (2008) (0)
- Cluster growth in a binary linear lattice (1974) (0)
- LacI follows a helical path while sliding along DNA (2013) (0)
- Duplication is more common among lateral transfer genes (2003) (0)
- Mutation load in sexual and asexual populations : Effects of distributed selection coefficients on stationary fitness and rate of fitness loss (2011) (0)
- Pattern formation in biology : a comparison of models and experiments H Meinhardt The helical structure of DNA facilitates binding (2016) (0)
- Eclipse period of R1 plasmids during downshift from elevated copy number: Nonrandom selection of copies for replication. (2012) (0)
- Near critical phenomena in metabolite pools (2003) (0)
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