Osamu Takeuchi
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Computer Science
Osamu Takeuchi's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Osamu Takeuchi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Pathogen Recognition and Innate Immunity (2006) (10861)
- Pattern Recognition Receptors and Inflammation (2010) (6956)
- A Toll-like receptor recognizes bacterial DNA (2000) (5463)
- Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. (1999) (3736)
- Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses (2006) (3609)
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. (1999) (3584)
- Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway (2003) (2770)
- Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002) (2545)
- IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction (2005) (2513)
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production (2008) (1656)
- TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity (2007) (1476)
- Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1 (2002) (1467)
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 (2008) (1460)
- Cell type-specific involvement of RIG-I in antiviral response. (2005) (1410)
- Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling1 (2002) (1369)
- Discrimination of bacterial lipoproteins by Toll-like receptor 6. (2001) (1343)
- Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1 (2001) (1173)
- Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1 (2000) (1142)
- TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway (2003) (1133)
- Innate immunity to virus infection (2009) (1132)
- Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 (2002) (1107)
- Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 (2004) (1048)
- The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010) (1020)
- Essential function for the kinase TAK1 in innate and adaptive immune responses (2005) (943)
- A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA (2006) (812)
- Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. (2005) (811)
- Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. (2009) (734)
- SOCS-1 participates in negative regulation of LPS responses. (2002) (681)
- Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin (2005) (666)
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response (2009) (659)
- Limb and skin abnormalities in mice lacking IKKalpha. (1999) (654)
- Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway1 (2000) (647)
- TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines (2008) (641)
- Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle (2009) (639)
- MDA5/RIG-I and virus recognition. (2008) (590)
- Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells1 (2001) (568)
- Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay (2009) (568)
- The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection (2004) (551)
- Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6 (2000) (550)
- LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses (2010) (544)
- Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. (2009) (542)
- Essential role of IPS-1 in innate immune responses against RNA viruses (2006) (522)
- TLR6: A novel member of an expanding toll-like receptor family. (1999) (514)
- Toll-like receptors; their physiological role and signal transduction system. (2001) (503)
- Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction (2005) (476)
- Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells (2006) (465)
- BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program (2010) (455)
- Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1 (2000) (450)
- Maturation of Human Dendritic Cells by Cell Wall Skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Involvement of Toll-Like Receptors (2000) (445)
- Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ (2004) (444)
- Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite1 (2001) (442)
- CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression1 2 3 (2001) (437)
- Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection (2009) (429)
- Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2 (2008) (426)
- Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses1 (2002) (413)
- C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia (2009) (378)
- Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. (2000) (372)
- Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. (2007) (350)
- Recognition of viruses by innate immunity (2007) (338)
- Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. (2002) (324)
- TLR9 as a key receptor for the recognition of DNA. (2008) (319)
- Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction (2002) (307)
- Candida albicans phospholipomannan is sensed through toll-like receptors. (2003) (304)
- Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice1 (2002) (298)
- A spatially and temporally restricted mouse model of soft tissue sarcoma (2007) (292)
- Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling (2006) (287)
- Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation (2013) (280)
- Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms (2015) (276)
- Pathogen recognition by innate receptors (2008) (259)
- Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages (2013) (247)
- Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. (2004) (241)
- Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. (2002) (240)
- Recognition of lipopeptides by Toll-like receptors (2002) (237)
- Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β1 (2001) (236)
- The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1 (2011) (226)
- Synergistic Effect of Muramyldipeptide with Lipopolysaccharide or Lipoteichoic Acid To Induce Inflammatory Cytokines in Human Monocytic Cells in Culture (2001) (223)
- p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis (2009) (213)
- Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers* (2002) (210)
- TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus (2008) (205)
- Mycobacterial Infection in TLR2 and TLR6 Knockout Mice (2003) (202)
- TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. (2003) (202)
- Genetic analysis of resistance to viral infection (2007) (202)
- Akirins, highly conserved nuclear proteins, required for NF-κB dependent gene expression in Drosophila and mice (2007) (197)
- Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. (2005) (197)
- Contribution of Receptor Editing to the Antibody Repertoire (2007) (191)
- Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense1 (2004) (190)
- Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. (2011) (188)
- Hepatitis C Virus Nonstructural Protein 5A Modulates the Toll-Like Receptor-MyD88-Dependent Signaling Pathway in Macrophage Cell Lines (2007) (179)
- A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. (2002) (178)
- Pathological role of Toll-like receptor signaling in cerebral malaria. (2006) (176)
- Simultaneous Blocking of Human Toll-Like Receptors 2 and 4 Suppresses Myeloid Dendritic Cell Activation Induced by Mycobacterium bovis Bacillus Calmette-Guérin Peptidoglycan (2003) (175)
- Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling (2007) (175)
- Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo (2013) (170)
- West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response (2012) (169)
- Novel Engagement of CD14 and Multiple Toll-Like Receptors by Group B Streptococci1 (2001) (166)
- Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. (2013) (165)
- Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways1 (2002) (164)
- Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. (2005) (164)
- Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells1 (2002) (158)
- Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells (2017) (157)
- MyD88 as a bottle neck in Toll/IL-1 signaling. (2002) (157)
- Negative Regulation of Platelet Clearance and of the Macrophage Phagocytic Response by the Transmembrane Glycoprotein SHPS-1* (2002) (157)
- Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense (2010) (156)
- Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. (2005) (152)
- Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. (2002) (152)
- Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. (2010) (149)
- Role of Lipoteichoic Acid in the Phagocyte Response to Group B Streptococcus1 (2005) (147)
- The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2* (2009) (145)
- Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced by Escherichia coli Infection in Mice1 (2000) (145)
- CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. (2003) (140)
- Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88 (2007) (138)
- TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. (2006) (130)
- Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway. (2002) (126)
- Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response (2012) (125)
- Hypercapnic Acidosis Attenuates Endotoxin-Induced Nuclear Factor-κB Activation (2003) (120)
- A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA (2009) (119)
- Mycoplasma fermentans Lipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions1 (2001) (117)
- Plasmodium berghei Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism1 (2001) (117)
- Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages1 (2004) (117)
- Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1 (2011) (115)
- Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 41 (2004) (113)
- The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling (2011) (112)
- Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis (2019) (112)
- Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. (2009) (111)
- Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. (2001) (111)
- TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis (2009) (110)
- TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA (2009) (107)
- Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis (2005) (104)
- Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration (2016) (102)
- Glycosylphosphatidylinositol‐anchored mucin‐like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP‐1 production by IFN‐γ‐primed‐macrophages (2002) (100)
- Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways1 (2009) (100)
- Toll-Like Receptor 2 Mediates Staphylococcus aureus–Induced Myocardial Dysfunction and Cytokine Production in the Heart (2004) (100)
- Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-α Production in Plasmacytoid Dendritic Cells1 (2009) (97)
- Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (2008) (97)
- Human lactoferrin activates NF‐κB through the Toll‐like receptor 4 pathway while it interferes with the lipopolysaccharide‐stimulated TLR4 signaling (2010) (96)
- Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432. (2003) (94)
- Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells1 (2006) (92)
- Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling1 (2006) (92)
- Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling (2014) (87)
- Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity (2014) (82)
- The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice (2011) (81)
- Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner (2009) (80)
- Signaling pathways activated by microorganisms. (2007) (79)
- Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex (2014) (79)
- Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction (2010) (76)
- A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence (2010) (74)
- Differential recognition of structural details of bacterial lipopeptides by toll‐like receptors (2002) (74)
- Codon bias confers stability to human mRNAs (2019) (74)
- Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. (2003) (72)
- The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation. (2012) (70)
- Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency (2007) (70)
- Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus (2013) (67)
- Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA (2016) (65)
- Differential inductions of TNF‐α and IGTP, IIGP by structurally diverse classic and non‐classic lipopolysaccharides (2006) (64)
- Genetic approaches to the study of Toll-like receptor function. (2002) (63)
- VP1686, a Vibrio Type III Secretion Protein, Induces Toll-like Receptor-independent Apoptosis in Macrophage through NF-κB Inhibition* (2006) (62)
- Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs (2013) (62)
- TANK is a negative regulator of Toll-like receptor signaling and critical for preventing autoimmune nephritis (2009) (62)
- IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil (2011) (61)
- Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression (2003) (60)
- Toxoplasma gondii–derived heat shock protein HSP70 functions as a B cell mitogen (2002) (59)
- NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements (2019) (59)
- Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice. (2000) (57)
- Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. (2002) (51)
- Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP (2013) (51)
- Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs. (2017) (48)
- Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction (2016) (48)
- TRAF Family Member-associated NF-κB Activator (TANK) Is a Negative Regulator of Osteoclastogenesis and Bone Formation* (2012) (46)
- Effect of steroid on hyperoxia-induced ICAM-1 expression in pulmonary endothelial cells. (2000) (46)
- Human Gingival CD14+ Fibroblasts Primed with Gamma Interferon Increase Production of Interleukin-8 in Response to Lipopolysaccharide through Up-Regulation of Membrane CD14 and MyD88 mRNA Expression (2002) (45)
- recognizes bacterial DNA (2000) (45)
- Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid (2008) (44)
- N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation (2019) (43)
- Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response (2017) (43)
- Expression of Toll-Like Receptor 2 ongd T Cells Bearing Invariant V g6/Vd1 Induced by Escherichia coli Infection in Mice (2000) (41)
- Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions (2016) (41)
- Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling. (2010) (41)
- Monocytic Cell Activation by Nonendotoxic Glycoprotein from Prevotella intermedia ATCC 25611 Is Mediated by Toll-Like Receptor 2 (2001) (41)
- Interferon response induced by Toll-like receptor signaling (2004) (40)
- Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation (2013) (39)
- Post-transcriptional regulation of immune responses by RNA binding proteins (2018) (39)
- Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. (2000) (39)
- Involvement of MyD88 in Host Defense and the Down-Regulation of Anti–Heat Shock Protein 70 Autoantibody Formation by MyD88 in Toxoplasma gondii–Infected Mice (2002) (38)
- Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis (2017) (37)
- Antiviral Activity of ANA773, an Oral Inducer of Endogenous Interferons that Acts Via TLR7, in Chronic Hepatitis C Patients (2011) (35)
- IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18 (2010) (35)
- CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan (2012) (35)
- Limited role of the Toll‐like receptor‐2 in resistance to Mycobacterium avium (2004) (34)
- Nucleic acid sensing by T cells initiates Th2 cell differentiation (2014) (33)
- Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs (2019) (33)
- Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player (2015) (32)
- Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest (2005) (31)
- Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation (2014) (29)
- The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells (2020) (29)
- Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses (2015) (28)
- RNA Recognition and Immunity—Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms (2020) (28)
- Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer (2013) (27)
- Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones (2015) (26)
- Endonuclease Regnase‐1/Monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) in controlling immune responses and beyond (2018) (26)
- Effect of hyperoxia on adhesion molecule expression in human endothelial cells and neutrophils. (1997) (26)
- The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation (2013) (25)
- [Pathogen recognition by innate immunity]. (2007) (24)
- Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant (2004) (24)
- Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation. (2000) (23)
- Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus (2018) (23)
- Normal Development of the Gut‐Associated Lymphoid Tissue Except Peyer's Patch in MyD88‐Deficient Mice (2003) (22)
- Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749-3752. (2016) (22)
- Common structural and expressional properties of vertebrate caldesmon genes. (1993) (22)
- Critical Role of AZI2 in GM-CSF–Induced Dendritic Cell Differentiation (2013) (21)
- RNA binding proteins in the control of autoimmune diseases (2019) (21)
- Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus. (2005) (21)
- Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1 (2020) (21)
- NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA (2012) (21)
- Experimental study of combination therapy with S-1 against pancreatic cancer (2009) (20)
- RIG-I-like antiviral protein in flies (2008) (19)
- A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway (2015) (19)
- Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B* (2014) (19)
- Translational control of mRNAs by 3′-Untranslated region binding proteins (2017) (18)
- Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia (2018) (17)
- The effects of codon bias and optimality on mRNA and protein regulation (2020) (15)
- Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non (2006) (15)
- TAK 1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells (2006) (14)
- [Cell type specific involvement of RIG-I in antiviral responses]. (2006) (14)
- IL‐33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation (2013) (13)
- HuR keeps interferon‐β mRNA stable (2015) (13)
- IRF3: a molecular switch in pathogen responses (2012) (12)
- Post‐transcriptional control of immune responses and its potential application (2019) (12)
- 5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival* (2015) (12)
- Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability (2015) (11)
- Interferon response induced by Toll-like receptor signaling. (2004) (10)
- Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling. (2008) (10)
- Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. (2011) (10)
- erratum A Toll-like receptor recognizes bacterial DNA (2001) (9)
- Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S‑1. (2019) (9)
- Mechanisms of metformin's anti‑tumor activity against gemcitabine‑resistant pancreatic adenocarcinoma. (2019) (9)
- Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells (2002) (9)
- Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin (2021) (8)
- Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA (2006) (8)
- PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases (2021) (8)
- Regnase-1 and Roquin regulate inflammatory mRNAs (2015) (7)
- Functional characterization of protein domains common to animal viruses and mouse (2011) (6)
- Hyperoxia and hypercapnic acidosis differentially alter nuclear factor-kappa B activation in human pulmonary artery endothelial cells. (1999) (6)
- Bcl-2/Bcl-xL inhibitor navitoclax increases the antitumor effect of Chk1 inhibitor prexasertib by inducing apoptosis in pancreatic cancer cells via inhibition of Bcl-xL but not Bcl-2 (2020) (6)
- Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor (2018) (6)
- Toll‐Like Receptors: Role in Inflammation and Cancer (2014) (6)
- Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells. (2016) (6)
- Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis. (2017) (5)
- Negative Regulators in Toll-like Receptor Responses (2010) (5)
- Regnase‐1–related endoribonucleases in health and immunological diseases (2021) (5)
- Induction of direct antimicrobial activity through mammalian toll-like receptors. (2001) (5)
- Effect of a combination of S-1 and gemcitabine on cell cycle regulation in pancreatic cancer cell lines (2012) (5)
- Endosomes/Lysosomes in Macrophages Fusion between Phagosomes and Inhibitory Effect of Toll-Like Receptor 4 on (2004) (4)
- Extracellular mRNA transported to the nucleus exerts translation-independent function (2021) (4)
- Glycogen synthase kinase‐3β participates in acquired resistance to gemcitabine in pancreatic cancer (2020) (4)
- Flesh‐eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor‐κB ligand (2016) (4)
- Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation (2014) (4)
- IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay (2021) (3)
- 88-Dependent Mechanism Receptor/Myeloid Differentiation Factor Liver Injury by an IL-12- and Toll-Like Infection in Mice Induces berghei Plasmodium (2001) (3)
- Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages. (2020) (3)
- [Control of inflammatory responses by a novel RNase, Zc3h12a]. (2009) (3)
- Receptor 4 Inflammatory Responses through Toll-Like Filamentous Actin Reorganization , and Involved in Bacterial Phagocytosis , Is Coxiella burnetii Lipopolysaccharide from (2004) (3)
- Live-cell imaging of protein degradation utilizing designed protein-tag mutant and fluorescent probe with turn-off switch. (2019) (3)
- Protein kinase R contributes to IFN- α / β production during viral infection by regulating IFN mRNA integrity (2010) (3)
- Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages (2022) (3)
- Codon Bias Confers Stability to mRNAs via ILF2 in Humans (2019) (2)
- Post-transcriptional regulation of immunological responses by Regnase-1-related RNases. (2021) (2)
- Multiplicative computation in a visual neuron sensitive to looming (2002) (2)
- Codon Optimality Confers GC-Rich-Induced Stability to mRNAs in Humans (2019) (2)
- Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I (2005) (2)
- Enhancement of Regnase-1 expression with stem loop–targeting antisense oligonucleotides alleviates inflammatory diseases (2022) (2)
- [Roles of Toll-like receptor in host defense and the mechanism of its signal transduction]. (2004) (2)
- NSD3 keeps IRF3 active (2017) (2)
- Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells (2022) (2)
- MyD 88-Deficient Dendritic Cells Endotoxin-Induced Maturation of Hoshino and Shizuo (2001) (2)
- Tank is a negative regulator of TLR signaling and critical for preventing autoimmune nephritis (2009) (2)
- Evaluation of Suppressive Effects of Tranilast on the Invasion/Metastasis Mechanism in a Murine Pancreatic Cancer Cell Line (2017) (1)
- [Efficacy of immunized milk for preventing viral infection]. (1999) (1)
- 2685: Utilizing Mouse Genetics to Dissect the Cellular Target and Molecular Mechanism of Acute and Late Toxicity of Abdominal Radiation Therapy (2006) (1)
- Independent Signaling Pathways Differentiation Factor 88-Dependent and Streptococcus Involve Parallel Myeloid Bactericidal Activity Against Group B Cellular Activation , Phagocytosis , and (2002) (1)
- Title A lipopolysaccharide from pantoea agglomerans is a promising adjuvant for sublingual vaccines to induce systemic and mucosal immune responses in Mice via TLR 4 pathway (2019) (1)
- Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model. (2020) (1)
- Title Inhibition of IL-1 R 1 / MyD 88 signalling promotes mesenchymalstem cell-driven tissue regeneration (2016) (1)
- TLR4 signaling: negative regulation by degradation (2007) (1)
- The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity (2022) (1)
- Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism (2022) (1)
- Author response: IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay (2021) (1)
- Functions Hydrophobic Portion in its Multiple by Toll-Like Receptor 2 : Role of N-Terminal MediatedM 161 Ag-Induced Cell Activation Is Lipoprotein Mycoplasma fermentans Toyoshima and Tsukasa Seya (2001) (1)
- Modulation of Adhesion Molecule Expression in Pulmonary Vascular Endothelium by Oxygen (1998) (0)
- Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins (2023) (0)
- Review for "Human T cells employ conserved AU‐rich elements to fine‐tune IFN‐γ production" (2019) (0)
- Functional significance of toll-like receptor-2 mediated signaling in the heart following acute ischemia/infarction (2003) (0)
- Flavivirus subgenomic non-coding RNA is required to overcome the host innate immune response (2009) (0)
- In Search of Commensurability in SLA Research(Invited Articles from JACET Chubu 2014, Nagoya) (2014) (0)
- Role of AZI 2 in osteoclastogenesis 1 5-azacytidine-induced protein 2 ( AZI 2 ) regulates bone mass by fine-tuning osteoclast survival (2015) (0)
- [Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin]. (2016) (0)
- Staphylococcus aureus Susceptible to MyD88-Deficient Mice Are Highly Cutting Edge: TLR2-Deficient and (2017) (0)
- N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation (2019) (0)
- Analyses of HAV IRES mediated translation contributing to viral tissue tropism (2017) (0)
- TAB3 in B Cell Activation via MAPKs Polyubiquitin-Binding Proteins TAB2 and Essential Roles of K63-Linked (2013) (0)
- Regnase-1 Zinc finger domain (2016) (0)
- 176: Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo (2013) (0)
- TRIF-Dependent Pathways Dendritic Cells via the IPS-1 and + α CD 8 Poly I : C-Induced Activation of NK Cells (2009) (0)
- Abstract 3273: The efficiency of anti-tumor effect of metformin for gemcitabine-resistant pancreatic adenocarcinoma (2016) (0)
- Immune response regulation by paralogous endoribonucleases: ZC3H12C and N4BP1 (2017) (0)
- Immunity to virus infection (excluding retroviruses) (PP-025) (2010) (0)
- Post-transcriptional control of immune responses via RNA binding proteins (2018) (0)
- Single-Stranded RNA of the Cytokine Response to Streptococcal NO Is a Macrophage Autonomous Modifier (2011) (0)
- Receptors | Toll-Like Receptors (2021) (0)
- Regnase-1 maintains iron homeostasis via the destabilization of iron-regulatory transcripts (2017) (0)
- Epigenetic regulation of innate immunity (2012) (0)
- Commentary HuR keeps Interferon-β mRNA stable (2017) (0)
- Abstract 3511: The mechanism of antitumor effect of metformin forgemcitabine-resistant pancreatic adenocarcinoma (2018) (0)
- Absence of Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction (2003) (0)
- Association of p60c-src with the membrane skeleton in rat forebrain (1992) (0)
- Title Regnase-1 and Roquin regulate inflammatory mRNAs (2018) (0)
- TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation (2021) (0)
- Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression. (2023) (0)
- The Roles of Two I (cid:2) B Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection (2004) (0)
- Abstract 3081: SHOC2 is a critical modulator of the sensitivity to EGFR-TKI in non-small cell lung cancer cells (2020) (0)
- Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia (2018) (0)
- Analyses of cell type specific translation from IRES mRNA derived from two different poliovirus strains (2016) (0)
- The Biology of Toll-Like Receptors in Mice (2007) (0)
- Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation (2014) (0)
- Model mouse which does not respond to bacterial cell components. (2000) (0)
- [Posttranscriptional control of inflammation by an RNase Regnase-1]. (2015) (0)
- [Innate immunity]. (2014) (0)
- Lipopolysaccharide-Inducible Genes the Expression of a Subset of Activation of IFN-Regulatory Factor 3 and MyD 88-Independent Pathway and Results in Lipopolysaccharide Stimulates the and Shizuo (2001) (0)
- Abstract 3122: Combination effect of metformin with gemcitabine for gemcitabine-resistant pancreatic adenocarcinoma (2014) (0)
- Toll-like receptor 2 signaling is important for fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection (2001) (0)
- MyoD-knockout mouse as a bacterial cell wall component-unansprechender animal model (2000) (0)
- [Regulation of immune responses by mRNA stability control]. (2010) (0)
- Gene Product Lps the Lipopolysaccharide: Evidence for TLR4 as to (TLR4)-Deficient Mice Are Hyporesponsive Cutting Edge: Toll-Like Receptor 4 (1999) (0)
- Toll-Like Receptors by Group B Streptococci Novel Engagement of CD 14 and Multiple (2001) (0)
- Recognition of Virus Invasion by Toll-Like Receptors and RIG-I-Like Helicases (2008) (0)
- The 79 th Annual Meeting of the Japanese Cancer Association Day 2 October 2 ( Friday ) (2020) (0)
- in B lymphocytes CD19 regulates innate immunity by the toll-like receptor RP105 signaling (2013) (0)
- Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response (P1228) (2013) (0)
- IRAK 1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated 1 mRNA decay 2 3 4 5 (0)
- An endoribonuclease Regnase-1 controls immune and iron homeostasis (2017) (0)
- B lineage-specific deletion of Bim leads to lymphoproliferative and autoimmune disease (159.23) (2012) (0)
- This information is current as Plasmacytoid Dendritic Cells Production in α of Viral Replication for IFN- Feedback Signaling Masks the Requirement Recognition Along with Type I IFN Positive Cutting Edge: TLR-Dependent Viral (2013) (0)
- NK cells and NK receptors (PP-007) (2010) (0)
- The role of subgenomic non-coding RNA in flavivirus-host interactions and viral pathogenicity (2009) (0)
- MCPIP3 (ZC3H12C) Regulates the Innate Immune Response by Acting as a Ribonuclease. (2016) (0)
- TANK prevents Pistane-induced alveolar hemorrhage by suppressing STING signaling (2017) (0)
- Chemokine Production by Renal Tubular Roles of Toll-Like Receptors in C-C (2002) (0)
- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation (2021) (0)
- Protozoan Parasite Glycosylphosphatidylinositol Anchors from a Activation of Toll-Like Receptor-2 by (2001) (0)
- Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of Toll-Like Receptors by Interacting with TANK-Binding Kinase 1 (2010) (0)
- Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice. (2005) (0)
- Response to Group B Streptococcus Role of Lipoteichoic Acid in the Phagocyte (2013) (0)
- Polyubiquitin-Binding Proteins TAB 2 and Essential Roles of K 63-Linked (2013) (0)
- MyD 88-Dependent Signaling Pathway Through a Toll-Like Receptor 2-and Lipopeptide-2 Activates Immune Cells Lipopeptide Macrophage-Activating-Stereoisomer of the Mycoplasmal R Cutting Edge : Preferentially the and Shizuo (1999) (0)
- Abstract 3840: Evaluation of the synergetic effect of a combination of dehydroxymethylepoxyquinomicin and gemcitabine on liver metastasis of pancreatic cancer (2012) (0)
- MyD88-Deficient Dendritic Cells Endotoxin-Induced Maturation of (2013) (0)
- CORRECTION (2000) (0)
- The role of flavivirus subgenomic non-coding RNA in overcoming host innate immune response (2009) (0)
- Cytoplasmic Pattern Receptors (RIG-I and MDA-5) and Signaling in Viral Infections (2009) (0)
- Abstract 5875: Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability (2020) (0)
- Cytokine Release in Early Phase Clearance of Factor 88-Dependent Proinflammatory Critical Roles of Myeloid Differentiation (2002) (0)
- Infection Staphylococcus aureus Susceptible to MyD 88-Deficient Mice Are Highly Cutting Edge : TLR 2-Deficient and (2000) (0)
- LipoproteinsMediating Immune Response to Microbial Cutting Edge: Role of Toll-Like Receptor 1 in (0)
- Regnase-1 C-terminal domain (2016) (0)
- StreptococcusResponse to Group B Role of Lipoteichoic Acid in the (2009) (0)
- Streptococcus Response to Group B Role of Lipoteichoic Acid in the Phagocyte (2005) (0)
- Kinase 1 TLRs by Interacting with TANK-Binding TRIF-Dependent Signaling Pathways of Akt Contributes to Activation of the (2010) (0)
- Dynamics and Topology of Human Transcribed Cis-regulatory Elements (2019) (0)
- Contribute to Antibacterial Defense Pneumococcal Pneumonia but Does Not Inflammatory Response to Murine Toll-Like Receptor 2 Plays a Role in the Early van der Poll (2004) (0)
- Signalling in pattern recognition (PP-057) (2010) (0)
- Coupling of translation and degradation of mRNAs in immune regulation (2019) (0)
- Abstract 2570: The mechanism of anti-tumor effect of metformin for gemcitabine-resistant pancreatic adenocarcinoma (2015) (0)
- Title Translation-dependent unwinding of stem ‒ loops by UPF 1 licenses Regnase-1 to degrade inflammatory mRNAs (2019) (0)
- Toll-Like Receptor 2 Mediates Staphylococcus aureus –Induced Myocardial Dysfunction and Cytokine Production in the Heart Molecular Cardiology (2004) (0)
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What Schools Are Affiliated With Osamu Takeuchi?
Osamu Takeuchi is affiliated with the following schools:
