Oksana Lockridge
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Oksana Lockridge's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
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(Suggest an Edit or Addition)Oksana Lockridge's Published Works
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Published Works
- Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products* (2003) (652)
- Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine (2002) (546)
- Comparison of butyrylcholinesterase and acetylcholinesterase. (1989) (481)
- Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. (2005) (479)
- Complete amino acid sequence of human serum cholinesterase. (1987) (351)
- Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse (2000) (333)
- Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses. (2015) (290)
- Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. (2000) (252)
- Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. (1997) (230)
- Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. (1990) (216)
- DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites. (1992) (213)
- Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior. (2010) (190)
- Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. (1989) (183)
- A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase. (1997) (161)
- Structure of the gene for human butyrylcholinesterase. Evidence for a single copy. (1990) (150)
- Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. (2004) (149)
- Mechanism of action of the flavoenzyme lactate oxidase. (1972) (149)
- Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase. (1980) (147)
- Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. (1995) (143)
- Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk. (2000) (139)
- Re-engineering butyrylcholinesterase as a cocaine hydrolase. (2002) (131)
- Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. (2001) (131)
- Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. (2008) (128)
- An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient. (1999) (128)
- Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization. (2002) (122)
- Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse. (2002) (122)
- Excessive hippocampal acetylcholine levels in acetylcholinesterase‐deficient mice are moderated by butyrylcholinesterase activity (2007) (121)
- Asp7O in the peripheral anionic site of human butyrylcholinesterase. (1996) (120)
- Interchain disulfide bonds and subunit organization in human serum cholinesterase. (1979) (117)
- Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase. (1997) (116)
- Comparison of atypical and usual human serum cholinesterase. Purification, number of active sites, substrate affinity, and turnover number. (1978) (116)
- Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase. (1995) (110)
- The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. (1991) (109)
- Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation. (2008) (107)
- Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities. (1999) (106)
- Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase. (1998) (104)
- A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India. (2007) (103)
- Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. (2007) (101)
- The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis. (1991) (101)
- Binding and hydrolysis of soman by human serum albumin. (2008) (100)
- Location of disulfide bonds within the sequence of human serum cholinesterase. (1987) (99)
- Pseudo-esterase Activity of Human Albumin (2008) (95)
- LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY. (2005) (92)
- Transamidating enzymes. II. A continuous fluorescent method suited for automating measurements of factor XIII in plasma. (1971) (92)
- Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. (2008) (91)
- Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. (1993) (91)
- Brain cDNA clone for human cholinesterase. (1987) (90)
- Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging. (2005) (90)
- Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure (2012) (89)
- Wild-Type and A328W Mutant Human Butyrylcholinesterase Tetramers Expressed in Chinese Hamster Ovary Cells Have a 16-Hour Half-Life in the Circulation and Protect Mice from Cocaine Toxicity (2002) (89)
- Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. (2002) (88)
- The active site of human paraoxonase (PON1) (2001) (88)
- The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency (2008) (87)
- Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. (2007) (86)
- Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. (1994) (81)
- Predicted Michaelis-Menten Complexes of Cocaine-Butyrylcholinesterase (2001) (80)
- Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents. (2010) (78)
- Phenotypic and molecular biological analysis of human butyrylcholinesterase variants. (1990) (77)
- A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters. (2008) (77)
- Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice (2003) (76)
- Tetramerization domain of human butyrylcholinesterase is at the C-terminus. (1997) (75)
- Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases. (2003) (75)
- Substance P Hydrolysis by Human Serum Cholinesterase (1982) (71)
- Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates. (1999) (70)
- Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters. (1998) (69)
- Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents. (2008) (68)
- Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG). (1990) (67)
- Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. (2012) (67)
- The butyrylcholinesterase knockout mouse is obese on a high-fat diet. (2008) (66)
- Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. (1999) (65)
- Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning (1998) (64)
- Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase. (1997) (64)
- Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. (2003) (64)
- Exposure to tri-o-cresyl phosphate detected in jet airplane passengers. (2011) (62)
- Structural approach to the aging of phosphylated cholinesterases. (2010) (62)
- Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. (2007) (62)
- Loss of the interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholinesterase. (1982) (62)
- Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors (2016) (61)
- Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase. (1993) (61)
- Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545. (2010) (60)
- Inactivation of a flavoprotein, lactate oxidase, by an acetylenic substrate. (1972) (58)
- The Butyrylcholinesterase K‐Variant Shows Similar Cellular Protein Turnover and Quaternary Interaction to the Wild‐Type Enzyme (2000) (57)
- Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase. (2007) (56)
- Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase. (1992) (55)
- Biomarkers of organophosphorus (OP) exposures in humans. (2011) (55)
- Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis. (2011) (54)
- Five Tyrosines and Two Serines in Human Albumin Are Labeled by the Organophosphorus Agent FP-Biotin (2008) (54)
- Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice (2004) (53)
- Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents (2018) (52)
- Aging of di-isopropyl-phosphorylated human butyrylcholinesterase. (1997) (51)
- A Mutation Linked with Autism Reveals a Common Mechanism of Endoplasmic Reticulum Retention for the α,β-Hydrolase Fold Protein Family* (2006) (50)
- Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine. (2010) (50)
- Development of diagnostics in the search for an explanation of aerotoxic syndrome. (2010) (50)
- Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates. (2010) (49)
- Structure of human serum cholinesterase (1988) (49)
- Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. (2011) (48)
- Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase. (2001) (48)
- Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity. (2009) (47)
- Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies. (2013) (47)
- Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India (2006) (46)
- Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case–control study of 1991 Gulf War veterans (2015) (46)
- Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin. (2015) (45)
- Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos. (2010) (45)
- DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase. (2002) (45)
- Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice (2003) (44)
- Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors (2004) (44)
- Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers. (1999) (44)
- Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. (2009) (44)
- Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates. (1991) (43)
- Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds (2011) (43)
- Recombinant human butyrylcholinesterase G390V, the fluoride-2 variant, expressed in Chinese hamster ovary cells, is a low affinity variant. (1993) (43)
- A novel method for purifying recombinant human host defense cathelicidin LL-37 by utilizing its inherent property of aggregation. (2007) (43)
- Mass spectral characterization of organophosphate-labeled lysine in peptides. (2009) (41)
- X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger. (2011) (40)
- Production of the butyrylcholinesterase knockout mouse (2007) (40)
- Mass spectrometry identifies multiple organophosphorylated sites on tubulin. (2009) (39)
- Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum (2009) (39)
- Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. (2009) (38)
- Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice (2003) (38)
- Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite. (2002) (38)
- Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. (2009) (37)
- Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies. (1981) (37)
- Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase. (2004) (36)
- Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system. (2010) (36)
- Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410). (2005) (36)
- Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. (2013) (35)
- Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population (2008) (34)
- Hydrolysis of methylprednisolone acetate by human serum cholinesterase. (1982) (34)
- Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus. (1999) (33)
- Characterization of a Novel BCHE “Silent” Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium (2014) (33)
- Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate. (2003) (33)
- Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma. (2000) (32)
- Protein tyrosine adduct in humans self-poisoned by chlorpyrifos. (2013) (32)
- Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose (2010) (32)
- A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. (2006) (32)
- Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon (2011) (32)
- Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. (2012) (31)
- Knockout of one acetylcholinesterase allele in the mouse. (1999) (31)
- Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice. (2008) (30)
- Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters. (2006) (30)
- Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. (2009) (29)
- Promoter and transcription start site of human and rabbit butyrylcholinesterase genes. (1994) (29)
- Bacterial expression and in vitro folding of the beta-subunit of human chorionic gonadotropin (hCG beta) and functional assembly of recombinant hCG beta with hCG alpha. (1994) (28)
- The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism. (1998) (28)
- Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate (2007) (28)
- The proline‐rich tetramerization peptides in equine serum butyrylcholinesterase (2012) (27)
- High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine. (2003) (27)
- Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing (1991) (27)
- Polyproline promotes tetramerization of recombinant human butyrylcholinesterase. (2014) (26)
- Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. (2005) (26)
- Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice (2008) (25)
- The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease (2009) (25)
- Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization. (1999) (25)
- Prolonged apnea following trimethaphan and succinylcholine. (1979) (24)
- Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium. (2014) (24)
- Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo. (2008) (23)
- Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase. (2007) (23)
- Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad. (2019) (23)
- Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. (2005) (23)
- Human serum albumin-based design of a diflunisal prodrug. (2013) (22)
- Evidence for a single butyrylcholinesterase gene in individuals carrying the C5 plasma cholinesterase variant (CHE2) (1990) (21)
- Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts. (2012) (21)
- Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. (2008) (21)
- Phenotype comparison of three acetylcholinesterase knockout strains (2007) (21)
- Kinetic analysis of effector modulation of butyrylcholinesterase‐catalysed hydrolysis of acetanilides and homologous esters (2008) (21)
- Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior. (2004) (21)
- Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography (2019) (20)
- Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase. (2013) (20)
- Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics. (2005) (20)
- Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly (2018) (20)
- Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis. (1999) (20)
- Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers. (2016) (20)
- Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent. (2002) (20)
- Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon. (2019) (19)
- Characterization of butyrylcholinesterase in bovine serum. (2017) (19)
- Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase (2007) (19)
- Tryptophan residue(s) as major components of the human serum paraoxonase active site. (1999) (18)
- Contributions of selective knockout studies to understanding cholinesterase disposition and function. (2010) (18)
- The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment (2017) (18)
- Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences. (2015) (17)
- Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association. (1998) (17)
- Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin. (2012) (17)
- Adenovirus-Transduced Human Butyrylcholinesterase in Mouse Blood Functions as a Bioscavenger of Chemical Warfare Nerve Agents (2009) (17)
- Naturally occurring mutation, Asp70His, in human butyrylcholinesterase (2002) (16)
- Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity (2018) (16)
- Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution. (2019) (16)
- Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons. (2011) (16)
- Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase. (2013) (15)
- Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant. (1999) (15)
- Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase. (2008) (15)
- Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond. (2013) (15)
- Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome. (2014) (15)
- Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide (2017) (15)
- Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice (2011) (15)
- The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate. (2011) (14)
- Prolonged Toxic Effects After Cocaine Challenge in Butyrylcholinesterase/Plasma Carboxylesterase Double Knockout Mice: A Model for Butyrylcholinesterase-Deficient Humans (2011) (14)
- Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase. (2006) (14)
- Butyrylcholinesterase: Overview, Structure, and Function (2011) (13)
- Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse. (2005) (13)
- Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers. (2016) (13)
- Molecular biology of human serum cholinesterase. (1986) (13)
- Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma. (2016) (13)
- Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure (2017) (13)
- Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment (2018) (12)
- Expression and Refolding of Functional Human Butyrylcholinesterase from E. Coli (1992) (12)
- Amino acid sequence of the active site of human serum cholinesterase from usual, atypical, and atypical-silent genotypes (1986) (12)
- Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry. (2012) (12)
- Biomarkers of organophosphate exposure (2006) (12)
- Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure (2017) (11)
- Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse. (2010) (11)
- The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. (2009) (11)
- Characterization of butyrylcholinesterase from porcine milk. (2018) (11)
- AMINO ACID COMPOSITION AND SEQUENCE OF HUMAN SERUM CHOLINESTERASE: A PROGRESS REPORT (1984) (11)
- Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice (2007) (11)
- Methamidophos, dichlorvos, O‐methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry (2010) (11)
- Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain. (2009) (11)
- Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase. (1998) (10)
- PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin. (2013) (10)
- Mutation His322Asn in human acetylcholinesterase does not alter electrophoretic and catalytic properties of the erythrocyte enzyme. (1994) (9)
- Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins (2016) (8)
- Detectable organophosphorus pesticide exposure in the blood of Nebraska and Iowa residents measured by mass spectrometry of butyrylcholinesterase adducts. (2013) (8)
- 4.14 – Esterases (2010) (8)
- Induction of plasma acetylcholinesterase activity and apoptosis in mice treated with the organophosphorus toxicant, tri-o-cresyl phosphate (2012) (8)
- Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants. (2004) (8)
- Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony. (2002) (8)
- Purification of recombinant human butyrylcholinesterase on Hupresin®. (2018) (8)
- Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease. (2007) (7)
- Biomarkers of Exposure to Organophosphorus Poisons: A New Motif for Covalent Binding to Tyrosine in Proteins That Have No Active Site Serine (2009) (7)
- The butyrylcholinesterase gene (BCHE) at 3q26.2 shows two RFLPs. (1991) (7)
- Markers of organophosphate exposure in human serum (2007) (7)
- Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor. (2013) (7)
- (20) Identification of organophosphate-reactive proteins by tandem mass spectrometry (2005) (6)
- Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate. (1973) (5)
- Intraperitoneal administration of 340kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats (2005) (5)
- Identification of organophosphate-reactive proteins by tandem mass spectrometry. (2005) (5)
- Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures (2016) (5)
- Argininosuccinate synthetase activity in cultured human lymphocytes (1977) (5)
- Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase (2007) (5)
- Human butyrylcholinesterase polymorphism: Molecular modeling. (2015) (5)
- Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry (2021) (5)
- Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides (2021) (5)
- Heat pretreatment eliminates spurious butyrylcholinesterase enhancement of endotoxin levels in the kinetic chromogenic assay. (2016) (4)
- Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis (2013) (4)
- Structural data on the aging of diethylphosphoryl-butyrylcholinesterase. (2005) (4)
- Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase (2020) (4)
- Immunological comparison of the usual and atypical human serum cholinesterase phenotypes (2004) (4)
- Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine. (2020) (4)
- Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids. (2017) (4)
- Naturally Occurring Epsilon Gamma Glutamyl Lysine Isopeptide Crosslinks in Human Neuroblastoma SH-SY5Y Cells (2022) (4)
- Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine. (2011) (4)
- Mutation of Human Butyrylcholinesterase Glycine 117 to Histidine Preserves Activity but Confers Resistance to Organophosphorus Inhibitors (1995) (3)
- Noncholinesterase Protein Targets of Organophosphorus Pesticides (2013) (3)
- Part 1: Genetic Variant of Human Acetylcholinesterase Part 2: SV-40 Transformed Cell Lines, for Example COS-1, but Not Parental Untransformed Cell Lines, Express Butyrylcholinesterase (BChE) (1992) (3)
- Endogenous butyrylcholinesterase in SV40 transformed cell lines: COS-1, COS-7, MRC-5 SV40, and WI-38 VA13 (1994) (3)
- Acetylcholinesterase Gene Sequence and Copy Number are Normal in Alzheimer’s Disease Patients Treated with the Organophosphate Metrifonate (1995) (3)
- Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP (2007) (3)
- Citrulline metabolism in normal and citrullinemic human lymphocyte lines (1975) (3)
- Organophosphorus Pesticides Promote Protein Cross-Linking (2022) (3)
- Identification of Carboxylesterase, Butyrylcholinesterase, Acetylcholinesterase, Paraoxonase, and Albumin Pseudoesterase in Guinea Pig Plasma through Nondenaturing Gel Electrophoresis. (2018) (3)
- Delipidation of Plasma Has Minimal Effects on Human Butyrylcholinesterase (2018) (3)
- Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan. (2011) (3)
- Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process. (1999) (3)
- Dichlorvos-induced formation of isopeptide crosslinks between proteins in SH-SY5Y cells. (2022) (2)
- Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine (2020) (2)
- Reaction of Human Butyrylcholinesterase (BChE) H117 Enzymes with Carbamates (1998) (2)
- Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells. (2022) (2)
- Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa) (2018) (2)
- Immunological comparison of the usual and atypical human serum cholinesterase phenotypes (1983) (1)
- The cross-linking action of organophosphorus poisons; Implications for chronic neurotoxicity (2020) (1)
- Affinity electrophoresis, a new way of separating usual from atypical serum cholinesterases (1976) (1)
- Subunit Association and Stabilization of Butyrylcholinesterase (BChE) (1995) (1)
- Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. (2020) (1)
- Comparison of Hupresin® to Procainamide-Sepharose for Purification of Butyrylcholinesterase and Acetylcholinesterase (2018) (1)
- Recombinant Human Butyrylcholinesterase G 390 V , Grant No . The Fluoride-2 Variant , Expressed in Chinese DAMD 1791-Z-1003 Hamster Ovary Cells , Is a Low Affinity Variant (1)
- Isolation of Genomic Clone for human Cholinesterase (1986) (1)
- CHRONIC ILLNESS FROM ORGANOPHOSPHORUS TOXICANT EXPOSURE (2018) (1)
- Structural Changes in the Active Site Gorge of Phosphylated Cholinesterase Accompanying the Aging Process (1998) (1)
- Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates. (2023) (1)
- Resistance of Human Butyrylcholinesterase to Methylene Blue‐Catalyzed Photoinactivation; Mass Spectrometry Analysis of Oxidation Products (2013) (1)
- CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer (2018) (1)
- Crystal structure of recombinant full length human butyrylcholinesterase (2007) (1)
- Overview of Adductomics in Toxicology (2023) (1)
- Phenotypic and Molecular Biological Analysis of Butyrylcholinesterase Variants Human (1990) (1)
- Crystal structure of human butyryl cholinesterase (2003) (1)
- Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking (2023) (1)
- Mass Spectrometry to Identify New Biomarkers of Nerve Agent Exposure (2008) (1)
- Genomic clones for human cholinesterase (1987) (1)
- electrophoretic and catalytic properties of the erythrocyte enzyme Mutation His322Asn in human acetylcholinesterase does not alter (2011) (1)
- ACHE Knockout Mouse; Cat AChE and Cat BChE Sequences; Tetramers of BChE (1998) (1)
- The physiological butyrylcholinesterase tetramer is a dimer of dimers stabilized by a superhelical assembly (2018) (0)
- Reaction of human butyrylchounesterase (BCHE) His-117 enzymes with carbamates (1997) (0)
- pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants (1998) (0)
- Reactions of human butyrylcholinesterase His-117 enzymes with carbamates (1997) (0)
- Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate (2005) (0)
- Abnormal processing of an autism‐linked Arg to Cys mutation in proteins of the α/β hydrolase fold family (2006) (0)
- Gene and Protein Therapy for Poisoning by Organophosphorus Agents (2002) (0)
- Crystal structure of fully glycosylated human butyrylcholinesterase (2012) (0)
- Structure of human butyrylcholinesterase inhibited by CBDP (2-min soak): Cresyl-phosphoserine adduct (2013) (0)
- Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification (2011) (0)
- G117H mutant of human butyrylcholinesterase in complex with sulfate (2010) (0)
- Crystal structure of soman-aged human butyryl cholinesterase (2003) (0)
- Expi 293 CELLS EXPRESSING AN ENDOGENOUS WILD-TYPE BUTYRYLCHOLINESTERASE, AND A VARIETY OF ESTERASES THAT SELF-REACTIVATES AFTER PHOSPHYLATION BY ALL TYPES OF ORGANOPHOSPHORUS AGENTS (2018) (0)
- Biomarkers of Exposure to Organophosphorus Poisons (2015) (0)
- Insect larvae: A novel expression system for human butyrylcholinesterase (1997) (0)
- Muscarinic acetylcholine receptors are down-regulated in acetylcholinesterase knockout mice (2004) (0)
- Acetylcholinesterase deficiency delays auditory system development in knockout mice (2001) (0)
- Comparative kinetics studies on human serum usual and atypical cholinesterases (1976) (0)
- 29) New genetic variants of human butyrylcholinesterase in the Brazilian population (2005) (0)
- Model of (-)-Cocaine-Bound (-)-Cocaine Hydrolase Complex (2002) (0)
- Butyrylcholinesterase GII7H/EI97Q is a somanase (1996) (0)
- Non-Aged Form of Mouse Acetylcholinesterase Inhibited by Tabun- Update (2008) (0)
- Butyrylcholinesterase In Human Protein Data (1992) (0)
- What we have learned from gene-targeted mice: acetylcholinesterase and butyrylcholinesterase knockouts (2006) (0)
- Structure of mouse acetylcholinesterase inhibited by CBDP (12-h soak) : Cresyl-phosphoserine adduct (2013) (0)
- Polyproline-Rich Peptides Organize Four Cholinesterase Subunits into a Tetramer; BChE and AChE Scavenge Polyproline Peptides Released during Metabolic Turnover (2020) (0)
- Expression of Human Butyrylcholinesterase in Trichoplusia ni Insect Larvae (1998) (0)
- Acetylcholinesterase knockout mice have increased sensitivity to scopolamine and atropine (2004) (0)
- BISTABLE DYNAMIC BEHAVIOR OF ENDOGENOUS BUTYRYLCHOLINESTERASE EXPRESSED IN Expi293 CELLS (2018) (0)
- List of contributors (2020) (0)
- Phenotype of the adult acetylcholinesterase-deficient mouse: evidence for a role of acetylcholinesterase in development (2004) (0)
- Biochemical Markers for Exposure to Low Doses of Organophosphorus Insecticides (2005) (0)
- Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine (2003) (0)
- THE CLONING OF OLD YELLOW ENZYME (1991) (0)
- Ultrastructural Characterization Of The Neuromuscular Junction In Diaphragm Of The Acetylcholinesterase Knockout Mouse (2002) (0)
- Butyrylcholinesterase Transcription Start Site and Promoter (1995) (0)
- Thebutyrylcholinesterase knockoutmousearesearchtool inthestudyofdrugsensitivity, bio-distribution,obesityand Alzheimer'sdisease (2009) (0)
- SUSTAIN MUSCLE FUNCTION IN ACETYLCHOLINESTERASE KNOCKOUT MICE (2004) (0)
- G117H mutant of human butyrylcholinesterase in complex with fluoride anion (2010) (0)
- Electrophysiological and Ultrastructural Characterization of Neuromuscular Junctions in Diaphragm Muscle of Acetylcholinesterase Knockout Mice (2008) (0)
- A Comparison of Blood Cholinesterase Activities, Pyridostigmine Inhibition of Red Cell Acetylcholinesterase, and Butyrylcholinesterase Phenotypes in Gulf War Veterans and Normal Controls (1998) (0)
- Acetylcholinesterase and Butyrylcholinesterase of Cat (1998) (0)
- Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM. (2020) (0)
- Peripheral Anionic Site of Wild-Type and Mutant Human Butyrylcholinesterase (1995) (0)
- Amino Acid Sequence of Human Cholinesterase (1985) (0)
- G117H mutant of human butyrylcholinesterase in complex with VX (2010) (0)
- X-Ray structures of native and soman-aged human butyrylcholinesterase: new insights into the catalytic mechanism of cholinesterases (2004) (0)
- Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase. (2013) (0)
- Crystal structure of human butyryl cholinesterase in complex with a choline molecule (2003) (0)
- G117H mutant of human butyrylcholinesterase in complex with echothiophate (2010) (0)
- Structure of mouse acetylcholinesterase inhibited by CBDP (30-min soak): cresyl-saligenin-phosphoserine adduct (2013) (0)
- Bert N. La Du, a Summary of His Career to 1998 (1998) (0)
- X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging (2005) (0)
- Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin (2023) (0)
- Abnormal processing of an autism-linked Arg to Cys mutation in proteins of the alfa/beta hydrolase fold family (2006) (0)
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