Ole Isacson
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(Suggest an Edit or Addition)Ole Isacson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009) (1558)
- Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease (2008) (1228)
- Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model (2002) (1214)
- Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis (2006) (684)
- Altered Proteasomal Function in Sporadic Parkinson's Disease (2003) (597)
- Failure of the ubiquitin–proteasome system in Parkinson's disease (2001) (530)
- Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats (2010) (479)
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease (2012) (461)
- Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease (1997) (459)
- Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years (2008) (435)
- Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. (2005) (421)
- Neuroinflammation of the nigrostriatal pathway during progressive 6‐OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging (2002) (386)
- Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. (2005) (357)
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy (2009) (352)
- Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum (1987) (348)
- Markers and Methods for Cell Sorting of Human Embryonic Stem Cell‐Derived Neural Cell Populations (2007) (335)
- Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum (1984) (300)
- Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease (2008) (289)
- Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival (1985) (274)
- Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. (1994) (272)
- Proteasome inhibition causes nigral degeneration with inclusion bodies in rats (2002) (266)
- Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. (2015) (266)
- Enhanced Yield of Neuroepithelial Precursors and Midbrain‐Like Dopaminergic Neurons from Human Embryonic Stem Cells Using the Bone Morphogenic Protein Antagonist Noggin (2007) (266)
- Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons (2002) (265)
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models (2016) (257)
- Survival of adult basal forebrain cholinergic neurons after loss of target neurons. (1990) (256)
- Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. (2000) (255)
- Transplantation of embryonic porcine mesencephalic tissue in patients with PD (2000) (253)
- Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: Correlation with PET, microdialysis, and behavioral data (1997) (246)
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction (2014) (240)
- Graft-induced behavioral recovery in an animal model of Huntington disease. (1986) (239)
- Porcine Xenografts in Parkinson's Disease and Huntington's Disease Patients: Preliminary Results (2000) (229)
- Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres (1995) (229)
- Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease (2002) (224)
- The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence (1994) (222)
- CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells (2009) (221)
- Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid (2010) (221)
- Striatal grafts in rats with unilateral neostriatal lesions—III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching (1988) (217)
- Blastula-Stage Stem Cells Can Differentiate into Dopaminergic and Serotonergic Neurons after Transplantation (1998) (215)
- Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC‐, hiPSC‐, and Non‐Human Primate iPSC‐Derived Dopaminergic Neurons (2013) (204)
- Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions (1993) (203)
- Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease (2004) (202)
- Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell‐specific manner (2003) (201)
- Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation. (1996) (201)
- Neural grafting in a rat model of huntington's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting (1985) (198)
- Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. (2009) (194)
- In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis (1986) (193)
- Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro. (1988) (187)
- Generalized brain and skin proteasome inhibition in Huntington's disease (2004) (181)
- A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon (1990) (177)
- Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh (2002) (174)
- Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum—I. Subcortical afferents (1988) (171)
- Intrastriatal Transforming Growth Factor α Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons (2004) (170)
- Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology (1996) (169)
- Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum—III. Efferent projecting graft neurons and their relation to host afferents within the grafts (1989) (167)
- Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models (2007) (164)
- The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons (2005) (163)
- Analysis of Different Promoter Systems for Efficient Transgene Expression in Mouse Embryonic Stem Cell Lines (2002) (158)
- Striatal grafts in rats with unilateral neostriatal lesions—I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway (1988) (157)
- Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids (1991) (154)
- Genetic selection of sox1GFP‐expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation (2006) (152)
- Neural grafting in a rat model of huntington's disease: Striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography (1987) (151)
- Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. (2007) (149)
- A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. (2001) (149)
- Impact of genomics on drug discovery and clinical medicine. (2000) (146)
- Progressive decline of glucocerebrosidase in aging and Parkinson's disease (2015) (140)
- The Threshold Theory for Parkinson's Disease (2017) (138)
- Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. (2014) (136)
- Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells (2003) (134)
- Embryonic Stem Cell‐Derived Pitx3‐Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence‐Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease (2008) (132)
- Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics (2009) (131)
- Long‐Term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (Cyno‐1) After Transplantation (2005) (131)
- Striatal grafts in rats with unilateral neostriatal lesions—II. In vivo monitoring of gaba release in globus pallidus and substantia nigra (1988) (129)
- Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons (2005) (126)
- Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research (2012) (126)
- Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons (1988) (125)
- Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells (2007) (123)
- Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers (1994) (120)
- Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease (2007) (120)
- Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. (1993) (120)
- Mitochondrial Impairment Reduces the Threshold for in Vivo NMDA-Mediated Neuronal Death in the Striatum (1993) (118)
- Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat (1996) (117)
- Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice (2005) (116)
- Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. (1999) (115)
- A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system (1995) (114)
- Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease. (1992) (109)
- Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons (2015) (106)
- A Novel Immunophilin Ligand: Distinct Branching Effects on Dopaminergic Neurons in Culture and Neurotrophic Actions after Oral Administration in an Animal Model of Parkinson's Disease (1998) (104)
- Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat (1987) (103)
- Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice (2015) (99)
- Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease (1998) (99)
- The production and use of cells as therapeutic agents in neurodegenerative diseases (2003) (97)
- Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. (2008) (97)
- Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease (1995) (95)
- Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors. (1999) (95)
- Clinical translation of stem cells in neurodegenerative disorders. (2012) (95)
- Stromal Cell–Derived Inducing Activity, Nurr1, and Signaling Molecules Synergistically Induce Dopaminergic Neurons from Mouse Embryonic Stem Cells (2006) (95)
- Gene therapy in the CNS (2000) (94)
- Integrated molecular landscape of Parkinson’s disease (2017) (94)
- Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism (1992) (94)
- Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging (2004) (92)
- Cytoarchitectonic Development, Axon-Glia Relationships, and Long Distance Axon Growth of Porcine Striatal Xenografts in Rats (1994) (91)
- Inhibition of the Dopamine D1 Receptor Signaling by PSD-95*♦ (2007) (91)
- The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration (2010) (90)
- Cellular Delivery of Trophic Factors for the Treatment of Huntington's Disease: Is Neuroprotection Possible? (1999) (89)
- Age dependence of striatal neuronal death caused by mitochondrial dysfunction. (1993) (86)
- Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF (1993) (84)
- Temporally induced Nurr1 can induce a non‐neuronal dopaminergic cell type in embryonic stem cell differentiation (2004) (84)
- Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. (1999) (83)
- Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage (1986) (83)
- Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. (2010) (83)
- Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. (1986) (82)
- Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits (2012) (82)
- Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. (2014) (81)
- Immunophilin Ligands and GDNF Enhance Neurite Branching or Elongation from Developing Dopamine Neurons in Culture (2000) (81)
- Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons (1990) (80)
- Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease (2019) (79)
- Neural precursors derived from human embryonic stem cells maintain long‐term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons (2007) (78)
- Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson’s disease (2008) (78)
- Viral and Inflammatory Triggers of Neurodegenerative Diseases (2012) (78)
- Neural transplantation studies reveal the brain's capacity for continuous reconstruction (1997) (77)
- Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task (1991) (77)
- Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection (2014) (77)
- PSD-95 Uncouples Dopamine–Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex (2009) (76)
- In vivo PET Imaging in rat of dopamine terminals reveals functional neural transplants (1998) (74)
- REVIEW ARTILCE: Cell therapy and stem cells in animal models of motor neuron disorders (2007) (73)
- Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome (2003) (73)
- Apoptosis in Neuronal Development and Transplantation: Role of Caspases and Trophic Factors (1999) (73)
- Selection of Embryonic Stem Cell‐Derived Enhanced Green Fluorescent Protein‐Positive Dopamine Neurons Using the Tyrosine Hydroxylase Promoter Is Confounded by Reporter Gene Expression in Immature Cell Populations (2007) (72)
- Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro (2006) (72)
- Intracerebral Grafting of Dopamine Neurons (1987) (71)
- Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion. (1988) (71)
- Benefits and risks of hosting animal cells in the human brain (1997) (70)
- Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. (1996) (67)
- Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease (2014) (66)
- Axonal Growth Regulation of Fetal and Embryonic Stem Cell‐Derived Dopaminergic Neurons by Netrin‐1 and Slits (2006) (66)
- The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress (2018) (65)
- Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro (1985) (64)
- Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease (2019) (64)
- Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts After Transforming Growth Factor α and Noggin Striatal Infusions into the Dopamine‐Depleted Striatum (2008) (63)
- Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors (1994) (63)
- Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism (2008) (62)
- Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system (1998) (61)
- Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease (2001) (61)
- Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons. (1997) (61)
- The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting (1986) (61)
- A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C) (2015) (61)
- Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition (2015) (61)
- Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain (2018) (59)
- NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. (1996) (59)
- Fetal homotypic transplant in the excitotoxically neuron‐depleted thalamus: Light microscopy (1988) (59)
- Stem cells may reshape the prospect of Parkinson's disease therapy. (2005) (57)
- Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates (2008) (57)
- Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence (2004) (55)
- Future of cell and gene therapies for Parkinson's disease (2008) (54)
- Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model (2003) (54)
- Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease. (1995) (52)
- Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2? (1999) (51)
- Developmental changes in brain kynurenic acid concentrations. (1992) (51)
- Dopamine Terminal Loss and Onset of Motor Symptoms in MPTP-Treated Monkeys: A Positron Emission Tomography Study with 11C-CFT (1994) (51)
- Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems (1992) (51)
- Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP‐32 striatal progenitors within the graft (2006) (50)
- Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation (2018) (50)
- Nerve growth factor receptor immunoreactivity in the rat suprachiasmatic nucleus (1989) (50)
- Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome (2003) (48)
- The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. (2010) (48)
- Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients (2009) (47)
- Behavioral effects and gene delivery in a rat model of Parkinson's disease (1995) (46)
- Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression (2012) (46)
- Motor Impairments, Striatal Degeneration, and Altered Dopamine-Glutamate Interplay in Mice Lacking PSD-95 (2014) (45)
- Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression (2009) (45)
- Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation (2011) (44)
- NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress. (1993) (44)
- Selective Antibody-Induced Cholinergic Cell and Synapse Loss Produce Sustained Hippocampal and Cortical Hypometabolism with Correlated Cognitive Deficits (2001) (43)
- Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. (2009) (43)
- Context-dependent neuronal differentiation and germ layer induction of Smad4 −/− and Cripto −/− embryonic stem cells (2005) (43)
- Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions (1986) (43)
- Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. (2008) (43)
- A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination (2002) (42)
- Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain. (1994) (42)
- Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum (2001) (41)
- Recent advances in cell-based therapy for Parkinson disease. (2008) (40)
- Oct4-Induced Reprogramming Is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons (2011) (40)
- Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson’s disease (2011) (40)
- Implanted NGF-Producing Fibroblasts Induce Catalase and Modify ATP Levels but Do Not Affect Glutamate Receptor Binding or NMDA Receptor Expression in the Rat Striatum (1994) (39)
- Antisense Gene Therapy for Neurodegenerative Disease? (1997) (39)
- Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. (2019) (39)
- Cell implantation therapies for Parkinson's disease using neural stem, transgenic or xenogeneic donor cells. (2001) (39)
- Parkinson's disease: interpretations of transplantation study are erroneous (2001) (38)
- Parkinsonian Motor Deficits Are Reflected by Proportional A9/A10 Dopamine Neuron Degeneration in the Rat (2001) (38)
- Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. (2002) (37)
- Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods. (1992) (37)
- A Primate Model of Huntington'S Disease: Functional Neural Transplantation and Ct-Guided Stereotactic Procedures (1992) (37)
- Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage (1985) (37)
- Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application. (1983) (35)
- Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum (1988) (35)
- PET- and MRI-Based Assessment of Glucose Utilization, Dopamine Receptor Binding, and Hemodynamic Changes after Lesions to the Caudate-Putamen in Primates (1994) (35)
- In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias (2007) (35)
- The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum. (1994) (35)
- Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse (2006) (34)
- Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON l-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease (2008) (34)
- A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen (2004) (34)
- Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance (2020) (33)
- The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies (2009) (33)
- Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study (2004) (33)
- Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington’s disease YAC128 mice (2016) (33)
- Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions. (1988) (31)
- Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats (2002) (30)
- An Endogenous Serine/Threonine Protein Phosphatase Inhibitor, G-Substrate, Reduces Vulnerability in Models of Parkinson's Disease (2007) (30)
- Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons. (1986) (29)
- Models of repair mechanisms for future treatment modalities of Parkinson’s disease (2002) (29)
- Immature and Neurally Differentiated Mouse Embryonic Stem Cells Do Not Express a Functional Fas/Fas Ligand System (2007) (29)
- Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates. (1990) (28)
- Glutamate Receptor Binding Sites in MPTP-Treated Mice (1993) (26)
- Neuronal replacement by intracerebral neural implants in animal models of neurodegenerative disease. (1988) (26)
- Cortico‐hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice (2002) (26)
- Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson’s Disease (2017) (25)
- Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice (2020) (25)
- Remodelling of intrinsic and afferent systems in neocortex with cortical transplants. (1990) (25)
- Neurotrophic Factor Protection against Excitotoxic Neuronal Death (1995) (25)
- Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age (2018) (25)
- Gene Therapy of Huntington’s Disease (1998) (25)
- Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (1994) (25)
- Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts (1997) (24)
- Effects of striatal excitotoxicity on huntingtin-like immunoreactivity (1995) (24)
- Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies. (1988) (23)
- In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells (2016) (23)
- Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex. (1995) (23)
- Survival of adult basal forebrain cholinergic neurons after loss of target neurons (1990) (22)
- Morris Water Maze Analysis of 192-IgG-Saporin-Lesioned Rats and Porcine Cholinergic Transplants to the Hippocampus (1999) (22)
- Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. (2009) (21)
- Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. (1999) (21)
- Neuroimmunophilin ligand enhances neurite outgrowth and effect of fetal dopamine transplants (2000) (21)
- Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder. (1997) (21)
- ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells. (2008) (20)
- The search for genetic mouse models of prodromal Parkinson's disease (2012) (20)
- Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease (2019) (19)
- Chapter 80 Magnetic resonance imaging of intracerebral neural grafts (1988) (19)
- Advantages and Recent Developments of Autologous Cell Therapy for Parkinson’s Disease Patients (2020) (19)
- Neurotrophic Factors NGF and FGF-2 Alter Levels of Huntingtin (IT15) in Striatal Neuronal Cell Cultures (2000) (18)
- Presence of Schwann cells in neurodegenerative lesions of the central nervous system (1989) (18)
- Pig Fetal Septal Neurons Implanted into the Hippocampus of Aged or Cholinergic Deafferented Rats Grow Axons and Form Cross-Species Synapses in Appropriate Target Regions (1999) (18)
- High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life (2010) (18)
- Magnetic resonance imaging to monitor pathology of caudate-putamen after excitotoxin-induced neuronal loss in the nonhuman primate brain (1992) (18)
- Striatal Neural Transplants in the Ibotenic Acid‐lesioned Rat Neostriatum (1987) (17)
- Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. (2012) (17)
- Striatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies. (1988) (17)
- Using stem cells and iPS cells to discover new treatments for Parkinson's disease. (2012) (17)
- Advances in stem-cell–generated transplantation therapy for Parkinson's disease (2014) (17)
- Effects of striatal excitotoxicity on Huntingtin‐like immunoreactivity (1995) (15)
- Problems and Solutions for Circuits and Synapses in Parkinson's Disease (2004) (15)
- Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. (2005) (14)
- A tyrosine hydroxylase–yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene (2006) (14)
- Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity (2020) (14)
- Survival of transplanted porcine neural cells treated with F(ab')2 antibody fragments directed against donor MHC class-I in a rodent model. (1996) (14)
- Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration. (2002) (13)
- Cell therapy ahead for Parkinson's disease. (2009) (13)
- ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress (2014) (13)
- Immunosuppressant Analogs in Neuroprotection (2002) (13)
- 6-[18F]fluoro-l-dopa uptake and [76Br]bromolisuride binding in the excitotoxically lesioned caudate-putamen of nonhuman primates studied using positron emission tomography (1992) (13)
- Neurobiology of Disease (2012) (12)
- Cholinergic Modulation of Amyloid Processing and Dementia in Animal Models of Alzheimer's Disease (2000) (12)
- Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration (1996) (11)
- Studies on host afferent inputs to fetal striatal transplants in the excitotoxically lesioned striatum. (1988) (11)
- Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology. (2001) (11)
- Trophic effects on cholinergic striatal interneurons by submaxillary gland transplants. (1988) (11)
- Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression (2018) (10)
- Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter (1993) (10)
- Intra-nigra infusion of AMPA attenuates dopamine-dependent rotation in the rat. (1993) (10)
- Neuronal xenotransplantation in Parkinson's disease (1997) (10)
- Fetal-Tissue Transplantation for Huntington’s Disease: Preclinical Studies (1998) (10)
- Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex (2004) (10)
- Immunobiology and Neuroscience of Xenotransplantation in Neurological Disease (1999) (8)
- Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2 (2021) (8)
- Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures. (2000) (8)
- The hAPP‐YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer’s disease and Down’s syndrome (2010) (8)
- Differential Neural Plasticity of Diffuse Monoaminergic and Point-to-Point Sensory Afferents as Demonstrated by Responses to Target Deprivation and Fetal Neural Transplants (1989) (8)
- Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. (1995) (8)
- hVMAT2: A Target of Individualized Medication for Parkinson’s Disease (2016) (8)
- The neurobiology and neurogenetics of stem cells. (1999) (7)
- Is there capacity for anatomical and functional repair in the adult somatosensory thalamus? (1992) (7)
- The Consequences of Coronavirus-Induced Cytokine Storm Are Associated With Neurological Diseases, Which May Be Preventable (2020) (7)
- Compensation of Lesion-Induced Changes in Cerebral Metabolism and Behaviour by Striatal Neural Implants in a Rat Model of Huntington’s Disease (1985) (7)
- Being too inclusive about synuclein inclusions (2010) (7)
- Sorting the wheat from the chaff in dopamine neuron-based cell therapies (2015) (7)
- Cellular and Molecular Treatments of Neurological Diseases (1999) (7)
- ES cell-derived neuroepithelial cell cultures. (2006) (7)
- Stem cells for Parkinson's disease: Advancing science but protecting patients (2012) (6)
- Part B: Directed Differentiation of Human Embryonic Stem Cells into Dopaminergic Neurons (2007) (6)
- Specific microRNAs modulate ES cell-derived neurogenesis (2005) (6)
- Lysosomes to combat Parkinson's disease (2015) (6)
- Intracerebral Neuronal Grafting in Experimental Animal Models of Age‐related Motor Dysfunction a (1988) (6)
- Parkinsonian monkeys with prior levodopa‐induced dyskinesias followed by fetal dopamine precursor grafts do not display graft‐induced dyskinesias (2017) (6)
- Trophic mechanisms are not enough (1989) (6)
- Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease (2021) (6)
- Conditions for Neuronal Survival and Growth as Assessed by the Intracerebral Transplantation Technique in Lesion Models of the Adult CNS (1987) (6)
- Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein‐1 (CD71) as a Negative Selection Marker for Human Neuronal Cells (2019) (6)
- Clinical and preclinical PET correlates of parkinsonism with 11C‐WIN 35,428 (1994) (5)
- Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? (2000) (5)
- Biological Gene-Product Delivery to the Brain: A Protocol for Retroviral Gene Transfer into Cultured Cells and Intracerebral Transplantation (1993) (5)
- CHOLECYSTOKININ CONTENT IN THE BASAL GANGLIA IN HUNTINGTONS-DISEASE - THE EXPRESSION OF CHOLECYSTOKININ IMMUNOREACTIVITY IN STRIATAL GRAFTS TO IBOTENIC ACID-LESIONED RAT STRIATUM (1985) (4)
- Transplanting Fetal Neural Xenogeneic Cells in Parkinson’s and Huntington’s Disease Models (1998) (4)
- Axonal growth regulation of fetal and ES-derived dopaminergic neurons by Netrin-1 and Slits (2006) (4)
- Embryonic Stem Cells Differentiated in Vitro as a Novel Source of Cells for Transplantation (1996) (4)
- Integrated molecular landscape of Parkinson’s disease (2017) (4)
- What are the long-term effects of neural grafting in patients with Huntington's disease? (2006) (3)
- Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk. (2020) (3)
- Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson’s Disease (2000) (3)
- Uses of Neuronal Transplantation in Models of Neurodegenerative Diseases (1986) (3)
- Cellular Delivery of Neurotrophic Factors as a Potential Treatment for Huntington's Disease (1999) (3)
- Magnetic resonance imaging of intracerebral neural grafts. (1988) (3)
- Herpes Simplex Virus/Adeno-Associated Virus Hybrid Vectors for Gene Transfer to Neurons (2002) (3)
- Cholecystokinin Content in the Basal Ganglia in Huntington's Disease (1985) (3)
- Extensive Axonal and Glial Fiber Growth from Fetal Porcine Cortical Xenografts in the Adult Rat Cortex (1995) (3)
- Differential Dissection of the Rat E16 Ventral Mesencephalon and Survival and Reinnervation of the 6-Ohda-Lesioned Striatum by a Subset of Aldehyde Dehydrogenase-Positive th Neurons (1997) (3)
- Title: Selection of embryonic stem cell derived eGFP+ dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations (2007) (2)
- Modulation of metabotropic glutamate subtype 5 receptor (mGluR5) in dyskinesia (2012) (2)
- Article Commentary: Development of the Human Striatum: Implications for Fetal Striatal Transplantation in the Treatment of Huntington's Disease (1995) (2)
- Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo (2002) (2)
- Brain Imaging as a Diagnostic Tool (2002) (2)
- The role of upstream lipid and metabolic systems in Alzheimer's disease, Parkinson's disease and dementias. (2022) (2)
- Protein Misfolding and Axonal Protection in Neurodegenerative Diseases (2009) (2)
- Gene Therapy for the Nervous System-Status (1995) (2)
- Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use. (2002) (2)
- Mapping dopamine receptors in the rodent and primate brain with IRON MRI: Comparison with dopamine receptor sub-type distributions (2001) (2)
- Cell Replacement Therapy for Huntington’s Disease (2009) (2)
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009) (2)
- No evidence for disease-like processes in fetal transplants (2009) (2)
- THE NEUROBIOLOGICAL AND CLINICAL POTENTIAL OF NEURAL CELL TRANSPLANTATION: SPECIAL ISSUE BASED ON THE MEETING OF THE AMERICAN SOCIETY FOR NEURAL TRANSPLANTATION, 1995. (1996) (2)
- A special issue based on the third annual conference of the American Society for Neural Transplantation, 1996. (1997) (1)
- Ole Isacson: development of new therapies for Parkinson's disease (interview). (2007) (1)
- The Therapeutic Potential of Stem Cells for Nervous System Diseases (2003) (1)
- Upregulating beta-hexosaminidase activity in rodents prevents alpha-synuclein lipid associations and protects dopaminergic neurons from alpha-synuclein-mediated neurotoxicity (2020) (1)
- Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex (1990) (1)
- Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease (2020) (1)
- A Primate Model of Huntington’s Disease: Unilateral Striatal Lesions and Neural Grafting in the Baboon (Papio papio) (1991) (1)
- The Neurobiological and Clinical Potential of Neural Cell Transplantation: Special Issue Based on the Meeting of the American Society for Neural Transplantation, 1995 (1996) (1)
- Agriculture: Beetles felled by potato RNA (2015) (0)
- Gene Transfer into the Central Nervous System: Neurotrophic Factors (1993) (0)
- Book Review: Cell Transplantation for Huntington's Disease (1995) (0)
- Title: Structural and Functional Brain Repair Studies of Pd Models by Novel Neurosurgical, Pet and Mri/mrs Methods Distribution Statement: Approved for Public Release Distribution Unlimited Report Documentation Page @bullett Sescnduimr nor Ani7atinw Vimiio Wir* Artnncccjdjs) Approved for Public Rele (2011) (0)
- Cell transplantation for huntington's disease: Reviewed by Dwaine F. Emerich CytoTherapeutics, Inc., 2 Richmond Square Providence, R1 02906 (1995) (0)
- NEURONAL PROTECTION AGAINST EXCITOTOXICITY. AUTHOR'S REPLY (1993) (0)
- Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease (2021) (0)
- S.16.01 Designing stem cells as therapeutic agents inneurological disease (2004) (0)
- Studies to examine the neuroprotective effect of ALDH1a1 in midbrain dopamine neurons (2008) (0)
- Embryonic stem cell-derived neural precursors, but not ventral mesencephalon-derived neural precursors, can be exponentially expanded in vitro while maintaining the developmental potential (2006) (0)
- Symposium S5: The Role of Complement in the Brain: The Good and the Bad (2004) (0)
- Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease. (2023) (0)
- Issue Information-Mission & Focus. (2016) (0)
- Morphological and behavioral changes following neural grafting in rats with ibotenate lesions of the anteromedial caudate putamen (1985) (0)
- Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease (2019) (0)
- Nigral and Striatal Grafts to the Lesioned Neostriatum: Models of Graft Function (1989) (0)
- Structural and Functional Brain Repair Studies of PD Models by Novel Neurosurgical, PET and MRI/MRS Methods (1999) (0)
- Faculty Opinions recommendation of Molecular diversity of midbrain development in mouse, human, and stem cells. (2018) (0)
- Editorial Board (2007) (0)
- Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease (2019) (0)
- hVMAT2: A Target of Individualized Medication for Parkinson’s Disease (2016) (0)
- Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2 (2021) (0)
- Neurotransplantation in the Treatment of Parkinson’s Disease (2012) (0)
- Faculty Opinions recommendation of MHC matching improves engraftment of iPSC-derived neurons in non-human primates. (2018) (0)
- Faculty Opinions recommendation of Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. (2017) (0)
- Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition (2015) (0)
- Cellular and Molecular Neuroscience : From Generation to Degeneration (2016) (0)
- Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson’s Disease (2016) (0)
- Repair mechanisms during neuronal regeneration (1987) (0)
- Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity (2020) (0)
- Neurodegenerative Diseases: Necessary methodological and stem cell advances for restoration of the dopaminergic system in Parkinson's disease patients (2005) (0)
- Knock-Out and Transgenic Strategies to Improve Neural Transplantation Therapy for Parkinson's Disease (2000) (0)
- Immunophilin Ligands and Dopamine Neurons (2003) (0)
- Morphological Aspects of Neuronal Dysfunction Caused by Protein Aggregation / Misfolding in Human Neurodegenerative Disorder (2008) (0)
- CHAPTER 21 – Therapeutic Transfer and Regeneration of Neural Progenitors or Neurons in Gray Matter of the Adult Brain (2005) (0)
- Feeder free differentiation of A9 and A10 type dopaminergic neurons from human pluripotent stem cells using small molecules (2011) (0)
- Faculty Opinions recommendation of Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. (2011) (0)
- A Special Issue Based on the Third Annual Conference of the American Society for Neural Transplantation, 1996 (1997) (0)
- Histopathological and Clinical Criteria for Analyzing Transplanted Human Dopamine Cells in Parkinson's Disease (2006) (0)
- Cell Stem Cell Previews Astrocytes on the Attack : Seeking Therapeutic Candidates by Modeling ALS Using Human Embryonic Stem Cells (0)
- Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age (2018) (0)
- IPS cell-derived retinal cell tranplantation (2017) (0)
- Neural Transplantation (2000) (0)
- Editorial Board and Contents (2017) (0)
- Therapeutic approaches: session XI summary and research needs. (2001) (0)
- O.106 Post-mortem analyses of fetal transplants of dopamine neurons in Parkinson's disease patients reveal no or minimal pathology (2009) (0)
- Meeting Report Problems and Solutions for Circuits and Synapses in Parkinson's Disease (2004) (0)
- Dopaminergic Neurons by Netrin-1 and Slits Axonal Growth Regulation of Fetal and Embryonic Stem Cell-Derived (2006) (0)
- Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease (2020) (0)
- Neuroregeneration Alfredo Gorio (Editor). Raven Press, New York, 1993. (1995) (0)
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What Schools Are Affiliated With Ole Isacson?
Ole Isacson is affiliated with the following schools:
