Oliver Smithies | Academic Influence

Oliver Smithies's AcademicInfluence.com Rankings

Oliver Smithies

Biology

#26

World Rank

#49

Historical Rank

#18

USA Rank

Genetics

#12

World Rank

#25

Historical Rank

#8

USA Rank

Biochemistry

#19

World Rank

#27

Historical Rank

#13

USA Rank

Molecular Biology

#40

World Rank

#40

Historical Rank

#28

USA Rank

biology Degrees

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Biology

Oliver Smithies's Degrees

PhD Biochemistry University of Oxford

Why Is Oliver Smithies Influential?

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According to Wikipedia, Oliver Smithies was a British-American geneticist and physical biochemist. He is known for introducing starch as a medium for gel electrophoresis in 1955, and for the discovery, simultaneously with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice. He received the Nobel Prize in Physiology or Medicine in 2007 for his genetics work.

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Oliver Smithies's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A comprehensive set of sequence analysis programs for the VAX (1984) (13626)
Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. (1955) (2481)
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. (1993) (1923)
Generation and reproductive phenotypes of mice lacking estrogen receptor beta. (1998) (1674)
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration (1995) (1164)
An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. (1959) (1138)
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse (1995) (1121)
The structure and evolution of the human β-globin gene family (1980) (1042)
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. (1996) (936)
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination (1985) (933)
An Animal Model for Cystic Fibrosis Made by Gene Targeting (1992) (928)
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. (1990) (912)
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. (1998) (861)
Mouse models of diabetic nephropathy. (2009) (853)
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. (1997) (743)
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells (1987) (739)
Human fetal g γ- and A γ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes (1980) (727)
Charon phages: safer derivatives of bacteriophage lambda for DNA cloning. (1977) (706)
Malefemale differences in fertility and blood pressure in ACE-deficient mice (1995) (664)
Genetic control of blood pressure and the angiotensinogen locus. (1995) (657)
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney (2006) (656)
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension (1995) (645)
Requirement of MIP-1 alpha for an inflammatory response to viral infection. (1995) (639)
Regulation of blood pressure by the type 1A angiotensin II receptor gene. (1995) (633)
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. (1995) (618)
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice (1993) (605)
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. (1997) (594)
A noninvasive computerized tail-cuff system for measuring blood pressure in mice. (1995) (584)
Zone electrophoresis in starch gels and its application to studies of serum proteins. (1959) (575)
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. (2000) (514)
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β (2002) (507)
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac. (1971) (484)
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. (1995) (452)
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. (1999) (428)
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. (1998) (402)
A Simple Hemagglutination System Requiring Small Amounts of Red Cells and Antibodies (1966) (389)
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. (2001) (354)
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. (2005) (340)
Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice (2017) (339)
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis (1992) (335)
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. (1998) (335)
Angiotensin-converting enzyme and male fertility. (1998) (325)
Single-copy transgenic mice with chosen-site integration. (1996) (319)
Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. (2000) (307)
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. (2001) (298)
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. (1999) (295)
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. (1998) (295)
A coagulation factor IX-deficient mouse model for human hemophilia B. (1997) (293)
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. (2000) (278)
Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. (1999) (273)
A history of the human fetal globin gene duplication (1981) (258)
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. (2006) (257)
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. (2004) (249)
Uncompensated polyuria in a mouse model of Bartter's syndrome. (2000) (245)
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. (1993) (242)
Chromosomal Rearrangements and the Evolution of Haptoglobin Genes (1962) (239)
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). (2000) (234)
A mouse model for beta 0-thalassemia. (1995) (231)
Altering genes in animals by gene targeting. (1992) (226)
The evolution of multigene families: human haptoglobin genes. (1986) (224)
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. (1989) (222)
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. (2001) (222)
Notation for Serum-Protein Groups and the Genes controlling their Inheritance (1956) (213)
Targeted mutation of the Hprt gene in mouse embryonic stem cells. (1988) (213)
Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections. (1978) (211)
Comparison and combination of the starch-gel and filter-paper electrophoretic methods applied to human sera: two-dimensional electrophoresis. (1958) (209)
Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. (1989) (209)
Generation and reproductive phenotypes of mice lacking estrogen receptor b (gene targetingyestrogen actionyovaryyfolliculogenesisyfertility) (1998) (203)
Altering mice by homologous recombination using embryonic stem cells. (1994) (202)
Genetic Control of some Serum Proteins in Normal Humans (1955) (195)
Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice (2001) (194)
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. (1997) (190)
Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene? (1972) (189)
Duplication within the haptoglobin Hp2 gene (1984) (188)
Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. (1984) (184)
Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. (1992) (183)
Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. (1994) (183)
Unexpected relationships between four large deletions in the human β-globin gene cluster (1983) (182)
Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells (1991) (179)
Inheritance of haptoglobin subtypes. (1962) (178)
Targeted disruption of the mouse topoisomerase I gene by camptothecin selection (1996) (177)
Variations in Human Serum β-Globulins (1957) (171)
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. (1999) (171)
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension. (1995) (169)
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. (1998) (167)
Recombinant fragment assay for gene targetting based on the polymerase chain reaction. (1988) (163)
Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. (1997) (160)
Human haptoglobins: estimation and purification. (1959) (160)
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse (2001) (153)
Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function (2003) (144)
Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-Like Receptor Gene (2006) (139)
A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster. (1986) (138)
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. (2004) (138)
Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis (1998) (137)
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration (2002) (135)
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. (2004) (133)
Genotype/Age Interactions on Aggressive Behavior in Gonadally Intact Estrogen Receptor β Knockout (βERKO) Male Mice (2002) (131)
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. (1996) (130)
Grouped Variations in the Occurrence of New Protein Components in Normal Human Serum (1955) (129)
Transforming growth factor-β1 and diabetic nephropathy. (2016) (129)
Impaired T cell function in RANTES-deficient mice. (2002) (125)
A mouse α-globin-related pseudogene lacking intervening sequences (1980) (122)
Animal models of human genetic diseases. (1993) (119)
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. (2007) (119)
Hybridization of labeled RNA to DNA in agarose gels. (1975) (117)
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice (2010) (115)
Molecular analysis of deletions in the human beta-globin gene cluster: deletion junctions and locations of breakpoints. (1990) (114)
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo (2006) (114)
Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP. (1996) (114)
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury (2007) (113)
Two-Dimensional Electrophoresis of Serum Proteins (1956) (112)
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. (2001) (109)
Disulfide-Bond Cleavage and Formation in Proteins (1965) (108)
Gene conversions and their relation to homologous chromosome pairing. (1986) (107)
Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. (2000) (107)
Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. (2000) (105)
The genetic control of transferrins in humans. (1959) (104)
Three‐dimensional diffusion tensor microscopy of fixed mouse hearts (2004) (104)
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. (2006) (104)
The kallikrein-kinin system in health and in diseases of the kidney. (2009) (104)
Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age* (2007) (102)
Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. (1985) (102)
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. (2006) (101)
Lactic Dehydrogenase: Genetic Control in Mana (1963) (100)
Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. (2000) (100)
Subdivision of the Three Common Haptoglobin Types based on ‘Hidden’ Differences (1962) (100)
Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme. (1997) (100)
Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. (2002) (99)
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. (2012) (98)
Importance of quantitative genetic variations in the etiology of hypertension. (2000) (94)
Genetic contributions to generalized arousal of brain and behavior (2003) (93)
Targeted disruption of hsp70.1 sensitizes to osmotic stress (2002) (93)
Homology requirements for unequal crossing over in humans. (1991) (89)
Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. (1990) (87)
Inherited Variations in the Serum Proteins of Cattle. (1958) (85)
Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. (1992) (85)
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. (1991) (85)
The structure and evolution of the human beta-globin gene family. (1980) (84)
Genetic Polymorphism of C'3(β1c-Globuiin) in Human Serum (1968) (84)
Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules (2017) (83)
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. (1997) (81)
RNA repair restores hemoglobin expression in IVS2–654 thalassemic mice (2009) (79)
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. (1993) (79)
CD8+ T Cells Are a Biologically Relevant Source of Macrophage Inflammatory Protein-1α In Vivo (1999) (78)
STARCH-GEL ELECTROPHORESIS. (1964) (78)
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. (1983) (77)
Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. (2005) (77)
Double-strand gap repair in a mammalian gene targeting reaction (1991) (77)
Tissue‐specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor‐α knock‐out mice (2008) (75)
Salt-Sensitive Blood Pressure in Mice With Increased Expression of Aldosterone Synthase (2008) (72)
Cotransformation and gene targeting in mouse embryonic stem cells (1991) (72)
Hinge-region deletion localized in the IgG-globulin Mcg. (1973) (72)
Antibody Variability (1967) (72)
Amino acids as modulators of endothelium-derived nitric oxide. (2006) (71)
A genetically clamped renin transgene for the induction of hypertension (2002) (71)
A common human beta globin splicing mutation modeled in mice. (1998) (70)
Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. (2007) (69)
Short gene conversions in the human fetal globin gene region: a by-product of chromosome pairing during meiosis? (1986) (69)
Human genetics, animal models and computer simulations for studying hypertension. (2004) (68)
Dog homologue of human 2 -microglobulin. (1972) (68)
Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. (2003) (68)
Kidney function in mice lacking aldosterone. (2006) (68)
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells* (1999) (68)
Restoration of Podocyte Structure and Improvement of Chronic Renal Disease in Transgenic Mice Overexpressing Renin (2009) (67)
A Chinese G gamma + (A gamma delta beta)zero thalassemia deletion: comparison to other deletions in the human beta-globin gene cluster and sequence analysis of the breakpoints. (1985) (67)
Improved renal function in mouse kidney allografts lacking MHC class I antigens. (1993) (66)
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. (2003) (66)
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice (2015) (65)
A Mouse View of Hypertension (1997) (65)
Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment (2007) (63)
Transferrin Variation in Columbidae. (1962) (63)
Renal growth and development in mice lacking AT1A receptors for angiotensin II. (1998) (63)
Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation. (1986) (62)
Gamma-Globulin Variability: A Genetic Hypothesis (1963) (62)
Third Allele at the Serum β-Globulin Locus in Humans (1958) (62)
Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. (1987) (62)
Chromosomal rearrangements and protein structure. (1965) (60)
Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. (1988) (60)
Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. (1997) (60)
Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice. (1999) (59)
Forty years with homologous recombination (2001) (59)
Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models. (1999) (58)
Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy (1994) (58)
Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. (1980) (58)
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. (2002) (58)
Base substitutions, length differences and DNA strand asymmetries in the human G γ and A γ fetal globin gene region (1981) (58)
Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. (2003) (58)
E-Prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation1 (2004) (58)
The kallikrein–kinin system and oxidative stress (2012) (57)
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy (2010) (56)
Clones from the human gene complex coding for salivary proline-rich proteins. (1984) (56)
Altering the expression in mice of genes by modifying their 3' regions. (2004) (55)
Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption (2006) (54)
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. (2002) (53)
Gene targeting approaches to analyzing hypertension. (1999) (52)
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension (2013) (52)
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. (2004) (51)
Molecular genetics of the apolipoprotein B gene in pigs in relation to atherosclerosis. (1988) (50)
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy (2011) (50)
Fetal Hemoglobin Variants in Mice (1968) (50)
Differential elution of histones from gel‐trapped nuclei (1969) (49)
Gene action in the human haptoglobins. I. Dissociation into constituent polypeptide chains. (1966) (49)
Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci. (1988) (49)
A dominant positive and negative selectable gene for use in mammalian cells. (1991) (48)
Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. (2001) (48)
Two novel arrangements of the human fetal globin genes: Gγ-Gγ and Aγ-Aγ (1984) (48)
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. (2006) (47)
Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing. (1978) (47)
Homologous recombination with DNA introduced into mammalian cells. (1984) (47)
Characterization of genetic variants of blood proteins. (1965) (47)
New Haptoglobin Alleles: A Prediction Confirmed (1963) (46)
Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. (2001) (46)
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. (2010) (46)
The kallikrein-kinin system in diabetic nephropathy (2012) (45)
Gene correction in hematopoietic progenitor cells by homologous recombination. (2000) (45)
Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia (2016) (44)
Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. (2001) (44)
Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. (1993) (44)
Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. (2002) (43)
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade (2015) (43)
Antibody responses in bursa-deficient chickens. (1966) (43)
Hypertension Associated with Decreased Testosterone Levels in Natriuretic Peptide Receptor-A Gene-Knockout and Gene-Duplicated Mutant Mouse Models1. (1999) (42)
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. (2005) (42)
Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension: Guyton Revisited Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney. Proc Natl Acad Sci U S A 103: 17985–17990, 2006 (2007) (41)
Molecular size and starch-gel electrophoresis. (1962) (40)
Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. (2002) (39)
Many little things: one geneticist's view of complex diseases (2005) (39)
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. (1987) (38)
Renal growth and development in mice lacking AT1A receptors for angiotensin II. (1998) (38)
Genetic Control of Some Human Serum β-Globulins (1958) (38)
Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis* (2006) (37)
Physiological Impact of Increased Expression of the AT1 Angiotensin Receptor (2003) (37)
High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy (2016) (36)
The control of globin and other eukaryotic genes (1982) (36)
Phosphorylation and synthesis of histones in regenerating rat liver. (1971) (36)
CD8+ T cells are a biologically relevant source of macrophage inflammatory protein-1 alpha in vivo. (1999) (35)
Antibody Induction and Tolerance. (1965) (35)
Serum Transferrins (1959) (35)
Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. (1986) (35)
Pathways through Networks of Branched DNA (1970) (34)
Correction of a human beta S-globin gene by gene targeting. (1991) (34)
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice* (1999) (34)
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. (2009) (34)
STARCH-GEL ELECTROPHORESIS OF ERYTHROCYTE STROMA. (1965) (34)
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene. (1985) (33)
Gene action in the human haptoglobins. II. Isolation and physical characterization of alpha polypeptide chains. (1966) (33)
Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1 (2013) (32)
Amino acid sequence determination with radioactive proteins. (1974) (32)
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males (2007) (32)
Coordinate modulation of transfected HSV thymidine kinase and human globin genes (1983) (31)
β2-Microglobulin locus on human chromosome 15 (1976) (31)
Deletions in Immunoglobulin Polypeptide Chains as Evidence for Breakage and Repair in DNA (1971) (31)
Tubuloglomerular feedback in ACE-deficient mice. (1999) (30)
High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells. (1995) (30)
β-MyHC and cardiac hypertrophy: size does matter. (2011) (30)
Antibody-producing cells in division. (1967) (30)
HLA membrane antigens: sequencing by intrinsic radioactivity. (1976) (29)
Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombination. (1988) (29)
Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene. (2005) (29)
(Aγδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA (1985) (27)
Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: establishment of new HPRT-deficient mouse embryonic stem cell lines. (1997) (26)
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. (1996) (26)
Heterogeneity of normal human immunoglobulin light chains. Nonallelic variation in the constant region of lambda chains. (1971) (25)
Introduction and expression of a fetal human globin gene in mouse fibroblasts (1982) (24)
Partial amino acid sequences of human and dog post-gamma globulins. (1981) (24)
The Genetic Basis of Antibody Variability (1967) (24)
Estrogen-induced osteogenesis in intact female mice lacking ERbeta. (2002) (24)
Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase (2016) (24)
A physical map of the human salivary proline-rich protein gene cluster covers over 700 kbp of DNA. (1990) (24)
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo (2008) (23)
Angiotensin-converting enzyme gene and atherosclerosis. (1997) (23)
Advances in Brief Genetic Disruption of Ptgs-1 , as well as of Ptgs-2 , Reduces Intestinal Tumorigenesis in Min Mice (2000) (22)
Nonrandom distribution of chromosomal proteins during cell replication. (1977) (22)
Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. (1988) (22)
The application of four methods for assessing protein homogeneity to crystalline beta-lactoglobulin: an anomaly in phase rule solubility tests. (1954) (22)
Theodore Cooper Memorial Lecture. A mouse view of hypertension. (1997) (21)
Is the kidney always the cause of hypertension? Distinct roles for the kidney and systemic tissues in blood pressure regulation by the Renin-Angiotensin system. J Clin Invest 115: 1092-1099, 2005 (2005) (21)
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. (2010) (21)
The structure and evolution of the human salivary proline-rich protein gene family (2004) (20)
Some thermodynamic and kinetic aspects of metabolic phosphorylation. (1948) (20)
Early days of gel electrophoresis. (1995) (20)
Human globin ψB2 is not a globin-related sequence (1982) (20)
High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3 (ß1e-globulin) polymorphism (1969) (19)
Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression. (2011) (19)
Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression. (2012) (18)
Frequencies of blood groups, serum haptoglobins and levels of slow alpha2-globulin in diabetics and their relatives. (1962) (18)
Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. (2010) (18)
Genetic variations in peroxisome proliferator-activated receptor γ expression affect blood pressure (2009) (17)
Using PAC nested deletions to order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus. (2001) (17)
LACTIC DEHYDROGENASE: GENETIC CONTROL IN MAN. (1963) (17)
Notation for Genetic Factors of Human Immunoglobulins* (1966) (17)
Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. (1993) (17)
Albuminuria in mice after injection of antibodies against aminopeptidase A: role of angiotensin II. (2001) (17)
Lifelong genetic minipumps. (2005) (17)
The role of transforming growth factor β1 in the regulation of blood pressure. (2014) (16)
Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. (1996) (16)
Problems encountered in detecting a targeted gene by the polymerase chain reaction. (1991) (15)
Low molecular weight urinary proteins. I. Partial amino acid sequences of the retinol-binding proteins of man and dog. (1975) (15)
Improvement of the Microtiter Hemagglutination Method (1968) (15)
Probable identity of tissue specific histone with encephalitogenic protein. (1972) (15)
Hematopoietic stem cells with controllable tEpoR transgenes have a competitive advantage in bone marrow transplantation. (2000) (15)
The occurrence of two unusual serum protein phenotypes in a single pedigree (1959) (15)
Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. (2004) (14)
Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite (2011) (14)
Gene modification via "plug and socket" gene targeting. (1996) (14)
A γGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice (2004) (14)
Multiple roles of adrenomedullin revealed by animal models (2002) (13)
Tubuloglomerular feedback in ACE-deficient mice. (1999) (13)
Zone electrophoresis of cabbage enzymes in starch gels. (1957) (13)
Targeted modification of human chromosomal genes. (1986) (13)
How it all began: a personal history of gel electrophoresis. (2012) (12)
Unusual genes at the aminoterminus of human immunoglobulin variants (1978) (12)
Evidence for inherited differences in the serum proteins of cattle (1957) (12)
A simplified chloral hydrate electrophoresis system for analysis of biological membranes. (1977) (12)
Partial amino acid sequences of rabbit and rat β2-microglobulins (1979) (12)
Partial amino acid sequences of rabbit and rat β2-microglobulins (1979) (12)
Partial amino acid sequences of rabbit and rat β2-microglobulins (1979) (12)
Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region. (1981) (12)
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. (2012) (12)
Decreased beta‐adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re‐express beta‐myosin heavy chain (2009) (12)
Immunoglobulin genes: arranged in tandem or in parallel? (1974) (12)
Isolating gene-corrected stem cells without drug selection. (2005) (11)
Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice (2018) (11)
GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure (2017) (11)
Mouse angiotensin receptor genes Agtrla and Agtr1b map to Chromosomes 13 and 3 (1997) (11)
Replication of plasmid DNA in fertilized Xenopus eggs is sensitive to both the topology and size of the injected template (2004) (11)
Pillars Article: Normal Development of Mice Deficient in β2M, MHC Class I Proteins, and CD8+ T Cells. Science. 248: 1227–1230 (2010) (11)
Characterization of prostaglandin H synthase 2 deficient mice and implications for mechanisms of NSAID action. (1997) (10)
Turning Pages (Nobel Lecture) (2008) (10)
Ren 1 d and Ren 2 cooperate to preserve homeostasis : evidence from mice expressing GFP in place of Ren 1 d (2001) (10)
A dynamic osmometer for accurate measurements on small quantities of material: osmotic pressures of isoelectric beta-lactoglobulin solutions. (1953) (9)
Variations in human serum beta-globulins. (1957) (9)
Transforming growth factor beta1 and aldosterone (2015) (9)
CHROMOSOMAL REARRANGEMENTS AND PROTEIN STRUCTURE. (1964) (9)
Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system (2018) (8)
Stable Oligomeric Clusters of Gold Nanoparticles: Preparation, Size Distribution, Derivatization, and Physical and Biological Properties (2014) (8)
Gender-Dependent Survival of Allogeneic Trophoblast Stem Cells in Liver (2009) (8)
Amino Acid Sequence Determination of Proteins Labeled in Tritium Gas by Microwave Discharge (1978) (7)
A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. (2004) (7)
High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3(beta 1-c-globulin) polymorphism. (1969) (6)
Nucleotide Sequence of 16-Kilobase Pairs of DNA 5 ’ to the Human e-Globin Gene * (2001) (6)
Science brick by brick (2010) (6)
Colour blindness: Still too many red–green figures (2014) (6)
General Discussion on Theories of Antibody Variability (1967) (6)
Components of the major urinary protein complex of inbred mice: Determination of NH2-terminal sequences and comparison with homologous components from wild mice (1974) (6)
A mouse alpha-globin-related pseudogene lacking intervening sequences. (1980) (6)
Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. (2019) (5)
An improved technique for tail-cuff blood pressure measurements with dark-tailed mice. (2005) (5)
Genetic polymorphism of C'3(beta1C-globulin) in human serum. (1968) (5)
(A gamma delta beta)0-Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. (1985) (4)
beta2-microglobulin locus on human chromosome 15. (1976) (4)
Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility. (2012) (4)
A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions (2016) (4)
Rapid Genotyping of Mice with Hemoglobinopathies and Globin Transgenes (1998) (4)
Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling (2021) (3)
Increased nitrous oxide emissions from Arctic peatlands after permafrost thaw (3)
Ren1 d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1 d (2001) (3)
Biochemical Aspects of the Inherited Variations in Human Serum Haptoglobins and Transferrins (2008) (3)
Alexander George Ogston. 30 January 1911–29 June 1996 (1999) (3)
How It All Began: A Personal History of Gel Electrophoresis. (2018) (3)
A Conversation with Oliver (2015) (2)
Transforming growth factor β 1 and diabetic nephropathy 1 2 (2015) (2)
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5 ' to the human 6 globin gene ( Alu repeat / chimpanzee sequence / evolution / Escherichia coli yS transposon (2)
Mouse natriuretic peptide receptor 3 gene maps to proximal Chromosome 15 (1997) (2)
Genetics of variability. (1968) (2)
Third allele at the serum beta-globulin locus in humans. (1958) (2)
Assignment of the gene for beta-2-microglobulin to human chromosome 15. (1976) (2)
Two novel arrangements of the human fetal globin genes: G gamma-G gamma and A gamma-A gamma. (1984) (2)
Kinins— The Kallikrein-Kinin System and Oxidative Stress (2013) (2)
Erratum: A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 5, (2070-2075) DOI:10.1073/pnas.1018766108) (2011) (2)
A mouse model for 10-thalassemia (2005) (2)
Alexander George Ogston 1911-1996 (1998) (2)
Angiotensinogen is Necessary for Postnatal Kidney Development • 1821 (1998) (2)
Expression of genes inserted at the human beta-globin locus by homologous recombination. (1987) (2)
CHARACTERIZATION OF GENETIC VARIANTS OF BLOOD PROTEINS. (1965) (2)
Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice. (1999) (2)
A5: Presence of a functional human renin-angiotensin system rescues the lethality and renal and cardiac abnormalities observed in angiotensinogen knock-out mice (1997) (2)
Erratum: Impaired mucosal defence to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2 (Journal of Clinical Investigation (2000) 105 (469-478)) (2000) (2)
Direct alteration of a gene in the human genome (1986) (2)
Development oh transgenic mice containing a functional human, but lacking a functional mouse reninangiotensin system (1996) (1)
Interstitial Fibrosis in Chronic Hydronephrosis is Modulated by Angiotensinogen Expression • 1797 (1998) (1)
265: Endothelin-1 overexpression mimics preeclampsia in pregnant mice (2015) (1)
Partial amino acid sequences of rabbit and rat B2 microglobulins (1975) (1)
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia (2010) (1)
Partial amino acid sequences of two urinary proteins characteristic of tubular proteinemia. (1971) (1)
GENOMIC CLONES FROM UNFRACTIONATED DNA (1979) (1)
A conversation with Oliver Smithies. (2015) (1)
Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells. (2011) (1)
[Nomenclature of genetically determined characteristics of human immunoglobulins]. (1966) (1)
Genetic control of some human serum beta-globulins. (1958) (1)
Towards an animal model of cystic fibrosis: targetted interruption of exon 10 of the CFTR gene in embryonic stem cells (1991) (1)
Manipulation of the mouse genome by homologous recombination. (1990) (1)
A conversation with Oliver Smithies. (2015) (1)
Extreme hydrops fetalis and abnormalities in mice lacking Adrenomedullin gene (2016) (1)
Quantitative genetic variations and essential hypertension. (1999) (1)
Regulation of blood pressure by the type 1 A angiotensin II receptor gene ( gene targeting / G protein-coupled receptor / hypertension ) (2005) (1)
-MyHC and Cardiac Hypertrophy (2011) (1)
Gene Targeting and Electroporation (1992) (1)
Experimental pathology - 1 (2009) (0)
CHARACTERIZATION OF HUMAN GLOBIN ψβ2 – A PHANTOM PSEUDOGENE (1982) (0)
Human globin psi B2 is not a globin-related sequence. (1982) (0)
An interview with... Oliver Smithies [interviewed by Magdalena Skipper]. (2005) (0)
Somatic mutations and proteins (1966) (0)
Development of transgenic animal models for studying the renin-angiotensin system in hypertension. Renal function and renal development (1996) (0)
On making animal models of common human genetic diseases by gene targeting (1992) (0)
Partial amino acid sequences of rabbit and rat beta 2-microglobulins. (1979) (0)
ALUNG May 20/5 (1999) (0)
Studying the Genetics of Complex But Common Human Diseases Using Mice (2000) (0)
In Vivo a Protein-1Source of Macrophage Inflammatory T Cells Are a Biologically Relevant + CD8 (1999) (0)
Erythropoietin-induced competitive expansion of transplanted tepor transgenic hematopoietic stem cells in vivo (1998) (0)
Mouse solutions to human problems (2001) (0)
Research Notes (2004) (0)
Technology advancement for studying gene expression and gene function: a workshop report (2004) (0)
Tissue Specific Regulation of ACE/ACE2 and AT 1 /AT 2 Receptor Gene Expression By Estrogen in ApoE/ER α Knock-Out Mice (2008) (0)
MR blockade protects against diet induced obesity , adipocyte dysfuntion and cardiac inflammation in mice , through browning of the adipose organ and modulation of autophagy (2014) (0)
TRANSGENE-INDUCED ENHANCEMENT OF HEMATO-VASCULAR DIFFERENTIATION FROM MURINE EMBRYONIC STEM CELLS (2004) (0)
kidney Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the (2006) (0)
Subject Index Vol. 16, 1976 (1976) (0)
CHARACTERIZATION OF HUMAN Gγ AND Aγ FETAL GLOBIN GENES (1980) (0)
Aldosterone‐dependent and ‐independent effects on renal potassium excretion (2008) (0)
Genetic Modifiers of Mortality and Kidney Structure in Type 1a (AT1A) Angiotensin II Receptor Deficiency (2000) (0)
in Acute Cutaneous Inflammation 2 Proinflammatory Actions of Prostaglandin E E-Prostanoid-3 Receptors Mediate the (2004) (0)
Letter: Recombinant DNA molecules. (1974) (0)
Cotransformation andGeneTargeting inMouseEmbryonic StemCells (1991) (0)
Forty years with homologous recombinations (2001) (0)
Lethal thalassemia after insertional disruption of the mouse major adult , 8-globin gene ( homologous recombination / gene targeting / locus control region ) (2005) (0)
GEL ELECTROPHORESIS: INTRODUCTORY REMARKS. (1964) (0)
INTRODUCTORY REMARKS (1964) (0)
Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system (2018) (0)
Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera. (2008) (0)
A tetraethylene glycol coat gives gold nanoparticles long in vivo half-lives with minimal increase in size (2017) (0)
Calmodulin Regulation of Ryanodine Receptor and Cardiac Hypertrophy(State-of-the-Art,Plenary Session 5 (PL-5) (M) Calcium Handling Abnormality in Heart Failure,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society) (2008) (0)
Protein sequencing with radioisotopes (1977) (0)
Breeding Scheme and Selection of Animals for DiaComp Experiments v2 (2019) (0)
An Interview With... (2005) (0)
Inhibition of angiotensin II increases hypothalamic thyroid hormone and stimulates orexigenic NPY/AgRP neurons (LB437) (2014) (0)
Dog homologue of β_2-microglobulin. (1972) (0)
Studies of Gene Action in the Haptoglobin System (1962) (0)
How Little Aldosterone is Able to Raise Blood Pressure (2009) (0)
Breeding Scheme and Selection of Animals for DiaComp Experiments v1 (2019) (0)
Inactivating the f 32-microglobulin locus in mouse embryonic stem cells by homologous recombination ( class I antigens / gene targeting ) (2004) (0)
Segregation of some chromosomal proteins during cell replication. (1978) (0)
Summary of the discussion for session No. 1 of the section on methods (1964) (0)
Correction (2013) (0)
Memorandum from Oliver Smithies to the Genetics Society of America (1976) (0)
GENE CONVERSIONS IN THE HUMAN FETAL CHROMOSOME PAIRING DURING MEIOSIS ? GLOBIN GENE REGION : A BY-PRODUCT (0)
Turning Pages: From Gels to Genes and Knock Out Mice (2008) (0)
Genetic variants that increase AT1 receptor expression preferentially raise blood pressure in females. (2002) (0)
Angiotensin-converting enzyme and male fertility (gene targetingyoviductysperm functionyzona pellucida) (1998) (0)
Altering the Expression in Mice of Genes by Modifying Their 3 (cid:1) Regions (2004) (0)
Decreased eNOS and high fat diet in diabetic nephropathy (2012) (0)
Kallikrein-kinin system in diabetes (2011) (0)
Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling (2021) (0)

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