Oliver Werz
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Engineering Biology
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(Suggest an Edit or Addition)Oliver Werz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- 5-Lipoxygenase: regulation of expression and enzyme activity. (2007) (439)
- 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. (2015) (361)
- The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes (*) (1995) (269)
- Therapeutic options for 5-lipoxygenase inhibitors. (2006) (232)
- Multi-target approach for natural products in inflammation. (2014) (222)
- Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. (2002) (221)
- Boswellic acids: biological actions and molecular targets. (2006) (213)
- 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. (2000) (212)
- 5-lipoxygenase: cellular biology and molecular pharmacology. (2002) (194)
- ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma (2008) (173)
- Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity (2018) (171)
- Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. (2002) (166)
- Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1 (2008) (156)
- 5-Lipoxygenase inhibitors: a review of recent developments and patents (2010) (154)
- Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. (2007) (153)
- Extracellular signal‐regulated kinases phosphorylate 5lipoxygenase and stimulate 5‐lipoxygenase product formation in leukocytes (2002) (148)
- Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation. (2005) (141)
- Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. (2008) (138)
- Boswellia serrata (2011) (135)
- Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents. (2011) (130)
- Phosphorylation‐ and stimulus‐dependent inhibition of cellular 5‐lipoxygenase activity by nonredox‐type inhibitors (2003) (127)
- Arachidonic Acid Promotes Phosphorylation of 5-Lipoxygenase at Ser-271 by MAPK-activated Protein Kinase 2 (MK2)* (2002) (122)
- Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense (2011) (114)
- Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review. (2009) (111)
- Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. (2012) (106)
- Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1 (2009) (105)
- Revealing the macromolecular targets of complex natural products. (2014) (104)
- Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders. (2015) (102)
- Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9 (2007) (100)
- The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages (2010) (99)
- Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. (1996) (98)
- Myrtucommulone from Myrtus communis Exhibits Potent Anti-Inflammatory Effectiveness in Vivo (2009) (96)
- Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. (2008) (96)
- Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds (2005) (96)
- The 5-Lipoxygenase Promoter Is Regulated by DNA Methylation* (2002) (96)
- Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. (2008) (95)
- ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. (2007) (94)
- Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. (2009) (94)
- Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production (2006) (93)
- Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase (2018) (91)
- Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products (2020) (90)
- Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. (2011) (87)
- Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells (2006) (83)
- Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes (2011) (82)
- Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (2013) (82)
- Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1 (2009) (81)
- Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. (2001) (79)
- Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1 (2012) (79)
- Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. (2000) (76)
- Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. (1998) (73)
- Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense1 (2009) (71)
- The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products (2007) (71)
- Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E2 Synthase-1 and Suppresses Prostaglandin E2 Formation in vivo (2010) (69)
- Celecoxib inhibits 5-lipoxygenase. (2008) (69)
- Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor γ (PPARγ) in the Conversion of White-to-brown Adipocytes* (2013) (67)
- Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding (2013) (67)
- Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome (2019) (65)
- The Atlas of Inflammation Resolution (AIR) (2020) (65)
- Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (2014) (64)
- Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. (2009) (63)
- Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). (2009) (62)
- Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. (2009) (62)
- Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation (2017) (61)
- Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males (2017) (61)
- Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo (2009) (60)
- Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase (2014) (59)
- Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. (2013) (59)
- Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. (2007) (59)
- Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors. (2005) (59)
- Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin. (2004) (59)
- Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. (2001) (58)
- Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro (2011) (56)
- On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance. (2009) (56)
- In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins. (2013) (56)
- Molecular pharmacological profile of the nonredox‐type 5‐lipoxygenase inhibitor CJ‐13,610 (2004) (55)
- Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone. (2017) (54)
- Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions. (2016) (54)
- Coupling of boswellic acid‐induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes (2004) (53)
- Small molecules intercept Notch signaling and the early secretory pathway. (2013) (53)
- Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity (2014) (53)
- p38 MAP kinase mediates stress‐induced leukotriene synthesis in a human B‐lymphocyte cell line (2001) (53)
- Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. (2009) (52)
- One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor. (2014) (52)
- SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. (2014) (52)
- Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil. (2017) (51)
- Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy. (2017) (49)
- Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Using Pharmacophore Models (2012) (49)
- Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca2+ and Differentially Interact with Platelet-Type 12-Lipoxygenase (2006) (49)
- Total synthesis of myrtucommulone A. (2010) (49)
- α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. (2015) (48)
- Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes (2016) (48)
- Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1). (2014) (47)
- The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase (2010) (47)
- Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors. (2015) (47)
- Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. (2002) (47)
- Increased Bioavailability of 11‐Keto‐β‐Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures (2012) (46)
- Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) (2011) (45)
- On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo (2012) (45)
- Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor† †Electronic supplementary information (ESI) available: Supplementary figures, data and methods. See DOI: 10.1039/c8sc02634c (2018) (44)
- Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. (2000) (44)
- Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions (2017) (44)
- Targeting de novo lipogenesis as a novel approach in anti-cancer therapy (2017) (40)
- Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening (2016) (40)
- Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). (2012) (40)
- Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans (2020) (39)
- Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase. (2014) (39)
- Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase. (2006) (39)
- Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors. (2012) (39)
- Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX. (2012) (38)
- 1-Oleoyl-2-acetylglycerol Stimulates 5-Lipoxygenase Activity via a Putative (Phospho)lipid Binding Site within the N-terminal C2-like Domain* (2005) (38)
- Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. (2010) (38)
- Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion (2015) (37)
- In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis. (2014) (37)
- SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction (2021) (37)
- V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy (2016) (37)
- High capacity for leukotriene biosynthesis in peripheral blood during pregnancy. (2013) (37)
- Process control and scale-up of modified bacterial cellulose production for tailor-made anti-inflammatory drug delivery systems. (2020) (37)
- Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis. (2018) (36)
- 2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors. (2016) (36)
- A test system for leukotriene synthesis inhibitors based on the in-vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6 (1997) (35)
- Structure and biosynthetic assembly of gulmirecins, macrolide antibiotics from the predatory bacterium Pyxidicoccus fallax. (2014) (35)
- Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. (2015) (35)
- Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase (2017) (34)
- An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis. (2014) (34)
- Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman. (2015) (34)
- 5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation (2016) (33)
- 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). (2016) (33)
- Purification of transforming growth factor beta 1 from human platelets. (1996) (33)
- Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms (2019) (33)
- Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. (2013) (33)
- Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction (2020) (33)
- Identification of rosmarinic acid as the major active constituent in Cordia americana. (2010) (32)
- The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP) (2014) (32)
- The Aminosteroid Phospholipase C Antagonist U-73122 (1-[6-[[17-β-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) Potently Inhibits Human 5-Lipoxygenase in Vivo and in Vitro (2005) (31)
- Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference. (2012) (31)
- Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds (2005) (31)
- Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening (2017) (31)
- Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution (2020) (31)
- Selective upregulation of TNF&agr; expression in classically‐activated human monocyte‐derived macrophages (M1) through pharmacological interference with V‐ATPase (2017) (31)
- Role of p38 mitogen‐activated protein kinase in linking stearoyl‐CoA desaturase‐1 activity with endoplasmic reticulum homeostasis (2015) (31)
- BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly. (2016) (31)
- Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid. (2011) (31)
- 3-O-Acetyl-11-keto-boswellic Acid Decreases Basal Intracellular Ca2+ Levels and Inhibits Agonist-Induced Ca2+ Mobilization and Mitogen-Activated Protein Kinase Activation in Human Monocytic Cells (2006) (30)
- Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. (2005) (30)
- Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum (2013) (29)
- Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. (2006) (29)
- The Atlas of Inflammation-Resolution (AIR) (2020) (28)
- Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria (2018) (28)
- Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR). (2014) (28)
- Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase (2011) (27)
- Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? (2016) (27)
- Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. (2008) (27)
- Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents (2017) (27)
- 12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3* (2013) (27)
- Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition[S] (2017) (27)
- Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations (2010) (27)
- Myxochelins target human 5-lipoxygenase. (2015) (26)
- The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria (2015) (26)
- The C2-like β-Barrel Domain Mediates the Ca2+-dependent Resistance of 5-Lipoxygenase Activity Against Inhibition by Glutathione Peroxidase-1* (2003) (26)
- Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase (2014) (26)
- Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors. (2015) (26)
- The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo. (2012) (26)
- Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils. (2011) (26)
- Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis. (2015) (26)
- The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. (2016) (26)
- A Multicomponent Carba‐Betti Strategy to Alkylidene Heterodimers – Total Synthesis and Structure–Activity Relationships of Arzanol (2012) (25)
- Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors (2016) (25)
- Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases. (2005) (25)
- GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. (2005) (25)
- Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death (2019) (24)
- Induction of central signalling pathways and select functional effects in human platelets by β‐boswellic acid (2005) (24)
- MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation. (2009) (24)
- The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation. (2016) (24)
- Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors. (2015) (24)
- Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase. (2015) (24)
- Cholesterol and its anionic derivatives inhibit 5‐lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells (2006) (24)
- Discovery of new potent molecular entities able to inhibit mPGES-1. (2018) (23)
- Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy (2017) (23)
- Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout. (2018) (23)
- The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response (2019) (23)
- Phytochemical Profile of the Aerial Parts of Sedum sediforme and Anti-inflammatory Activity of Myricitrin (2015) (23)
- Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. (2016) (23)
- Chromatographic separation and biological evaluation of benzimidazole derivative enantiomers as inhibitors of leukotriene biosynthesis. (2014) (23)
- Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol. (2003) (23)
- Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach. (2014) (22)
- Cell type‐dependent activation of 5‐lipoxygenase by arachidonic acid (2003) (22)
- Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity (2018) (22)
- Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5‐Lipoxygenase Inhibitors (2015) (22)
- Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. (2017) (21)
- Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum. (2014) (21)
- Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase. (2014) (21)
- Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. (2016) (20)
- Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP. (2015) (20)
- Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E. (2017) (20)
- Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification (2016) (20)
- The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5‐lipoxygenase in polymorphonuclear leukocytes (2008) (19)
- Leukotriene‐mediated sex dimorphism in murine asthma‐like features during allergen sensitization (2019) (19)
- Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. (2019) (19)
- A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2017) (19)
- Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis (2019) (19)
- NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum. (2017) (19)
- Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade"). (2016) (19)
- Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study. (2016) (19)
- The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains. (2017) (18)
- Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones. (2006) (18)
- Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy. (2019) (18)
- Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol (2015) (17)
- Matrix‐based Molecular Descriptors for Prospective Virtual Compound Screening (2017) (17)
- Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening. (2017) (17)
- Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1. (2011) (17)
- Simplified pretubulysin derivatives and their biological effects on cancer cells. (2014) (17)
- Structure‐Based Design of Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors using a Virtual Fragment Growing Optimization Scheme (2016) (16)
- A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2). (2012) (16)
- A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold. (2011) (16)
- Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration (2013) (16)
- Melleolides induce rapid cell death in human primary monocytes and cancer cells. (2014) (16)
- Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416. (2012) (16)
- Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles. (2021) (15)
- Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. (2018) (15)
- Determination of myrtucommulone from Myrtus communis in human and rat plasma by liquid chromatography/tandem mass spectrometry. (2011) (15)
- Chemometrics-guided development of a cyclodextrin-modified micellar electrokinetic chromatography method with head-column field amplified sample stacking for the analysis of 5-lipoxygenase metabolites. (2012) (15)
- Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation (2019) (15)
- Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B. (2016) (15)
- Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: the battle between pro- and anti-inflammatory lipid mediators. (2021) (14)
- Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions. (2010) (14)
- Development and Characterization of Bacterial Nanocellulose Loaded with Boswellia Serrata Extract Containing Nanoemulsions as Natural Dressing for Skin Diseases. (2020) (14)
- Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity (2020) (14)
- Particulate transepithelial drug carriers: barriers and functional polymers (2012) (14)
- Interference of Boswellic Acids with the Ligand Binding Domain of the Glucocorticoid Receptor (2014) (14)
- Particulate transepithelial drug carriers: barriers and functional polymers (2012) (14)
- Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase. (2019) (14)
- Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7. (2018) (14)
- Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered Myxococcus xanthus Strain. (2019) (14)
- Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells (2020) (13)
- Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G (2018) (13)
- From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space (2012) (13)
- The interplay between depression and tuberculosis (2019) (13)
- Improved bioactivity of the natural product 5-lipoxygenase inhibitor hyperforin by encapsulation into polymeric nanoparticles. (2020) (13)
- Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action. (2016) (12)
- Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes. (2015) (12)
- SAR studies of acidic dual γ-secretase/PPARγ modulators. (2011) (12)
- Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. (2021) (12)
- Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. (2019) (12)
- Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators. (2021) (12)
- Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase. (2008) (12)
- Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections (2021) (12)
- Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans. (2018) (12)
- Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. (2014) (12)
- Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design (2021) (12)
- Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A. (2015) (12)
- The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis. (2019) (12)
- Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. (2018) (12)
- Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis (2019) (12)
- Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37. (2015) (12)
- Melleolides impact fungal translation via elongation factor 2. (2019) (11)
- Diversity of Chromanol and Chromenol Structures and Functions: An Emerging Class of Anti-Inflammatory and Anti-Carcinogenic Agents (2020) (11)
- Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice (2018) (11)
- Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids. (2019) (11)
- Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors (2015) (11)
- ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids (2021) (11)
- Associated Bacteria Affect Sexual Reproduction by Altering Gene Expression and Metabolic Processes in a Biofilm Inhabiting Diatom (2019) (11)
- Extracellular signal-regulated kinase-2 phosphorylates RORα4 in vitro (2007) (11)
- Myrtucommulone from Myrtus communis: Metabolism, Permeability, and Systemic Exposure in Rats (2012) (11)
- Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1. (2012) (10)
- Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors. (2016) (10)
- Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase. (2019) (10)
- Survey of the C20 and C22 oxylipin family in marine diatoms (2018) (10)
- Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds (2020) (9)
- Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways. (2021) (9)
- CyreneTM as an alternative sustainable solvent for the preparation of poly(lactic-co-glycolic acid) nanoparticles. (2020) (9)
- Pharmacophore-based discovery of a novel cytosolic phospholipase A2α inhibitor (2012) (9)
- Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction (2020) (9)
- Olive Oil Extracts and Oleic Acid Attenuate the LPS-Induced Inflammatory Response in Murine RAW264.7 Macrophages but Induce the Release of Prostaglandin E2 (2021) (9)
- Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1. (2014) (9)
- 5-Lipoxygenase activation by MAPKAPK-2 and ERKs. (2003) (9)
- New vitamin D receptor agonists with decreased metabolic stability. (2000) (8)
- 5-Lipoxygenase: Regulation and Pharmacology (2004) (8)
- A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors (2020) (8)
- A Multi‐step Virtual Screening Protocol for the Identification of Novel Non‐acidic Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors (2018) (8)
- Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. (2016) (8)
- Evaluation of hyperforin analogues for inhibition of 5-lipoxygenase. (2005) (8)
- Effect of Crystallinity on the Properties of Polycaprolactone Nanoparticles Containing the Dual FLAP/mPEGS-1 Inhibitor BRP-187 (2021) (8)
- Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. (2020) (8)
- 5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse. (2020) (8)
- A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection. (2015) (8)
- Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing (2021) (8)
- Pirinixic acids: flexible fatty acid mimetics with various biological activities. (2015) (8)
- Myxochelin‐Inspired 5‐Lipoxygenase Inhibitors: Synthesis and Biological Evaluation (2017) (8)
- Hypertonicity suppresses ionophore‐induced product formation and translocation of 5‐lipoxygenase in human leukocytes (2002) (8)
- A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. (2019) (8)
- Modulation of microRNA processing by 5‐lipoxygenase (2020) (7)
- Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination (2022) (7)
- Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population. (2019) (7)
- Regulation of inflammatory pathways by an a-tocopherol long-chain metabolite and a d-tocotrienol-related natural compound. (2014) (7)
- Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro. (2007) (7)
- The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka (2020) (7)
- Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones. (2017) (7)
- Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery (2021) (7)
- Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201 (2022) (7)
- Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol (2020) (7)
- Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels. (2020) (7)
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition (2017) (6)
- A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts (2018) (6)
- Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics (2020) (6)
- Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages. (2021) (6)
- pH-Dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin (1997) (6)
- Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct. (2012) (6)
- Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis (2020) (6)
- Caulerpenyne and Related Bis‐enol Esters Are Novel‐Type Inhibitors of Human 5‐Lipoxygenase (2014) (6)
- Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism (2019) (6)
- Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol. (2018) (6)
- Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides (2021) (6)
- Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation (2021) (6)
- Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions (2020) (6)
- A Thromboxane A2 Receptor-Driven COX-2–Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis (2022) (6)
- Analysis of Boswellic Acid Contents and Related Pharmacological Activities of Frankincense-Based Remedies That Modulate Inflammation (2021) (6)
- DNA methylation regulates 5-lipoxygenase promoter activity. (2003) (6)
- Aging drives organ‐specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice (2021) (5)
- Regulation of 5-lipoxygenase activity by selenium-dependent peroxidases-effects of transforming growth factor-beta and 1,25-dihydroxyvitamin D3. (1997) (5)
- Sex Hormone–Dependent Lipid Mediator Formation in Male and Female Mice During Peritonitis (2022) (5)
- Phorbol ester upregulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes (2001) (5)
- The indirubin derivative 6-bromoindirubin-3'-glycerol-oxime ether (6BIGOE) potently modulates inflammatory cytokine and prostaglandin release from human monocytes through GSK-3 interference. (2020) (5)
- Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors (2018) (5)
- 2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo (2011) (5)
- Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea (2016) (5)
- An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin. (2019) (5)
- CHAPTER 1:Microsomal Prostaglandin E2 Synthase-1 (2012) (4)
- Bioactivity and Mode of Action of Bacterial Tetramic Acids. (2019) (4)
- Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts (2017) (4)
- From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution (2021) (4)
- Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells (2022) (4)
- Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages. (2022) (4)
- Candida albicans‐induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology (2021) (4)
- The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages (2021) (4)
- Separation of 5-Lipoxygenase Metabolites Using Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography and Head Column Field-Amplified Sample Stacking (2013) (4)
- Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. (2022) (4)
- Macrophage-targeting oligopeptides from Mortierella alpina (2022) (4)
- The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators (2021) (4)
- Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent. (2002) (4)
- The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. (2021) (4)
- Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy. (2021) (4)
- A selective modulator of peroxisome proliferator-activated receptor γ with unprecedented binding mode. (2020) (4)
- SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. (2015) (4)
- 15‐Hydroperoxy‐PGE2: Intermediate in Mammalian and Algal Prostaglandin Biosynthesis (2019) (3)
- Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation (2022) (3)
- Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583] (2015) (3)
- Discovery of N-Amido-Phenylsulfonamide Derivatives as Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. (2021) (3)
- The aminosteroid phospholipase C antagonist U-73122 potently inhibits human 5-lipoxygenase in vivo and in vitro * (2005) (3)
- Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis (2020) (3)
- Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood (2021) (3)
- Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care (2022) (3)
- Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. (2009) (3)
- Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors (2022) (2)
- Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition (2021) (2)
- A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum (2015) (2)
- In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum (2010) (2)
- Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model (2021) (2)
- Drug delivery of 6-bromoindirubin-3’-glycerol-oxime ether employing poly(d,l-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents (2022) (2)
- Staphylococcus aureus controls eicosanoid and specialized pro‐resolving mediator production via lipoteichoic acid (2022) (2)
- Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy (2020) (2)
- 262 Canephron® N reduces pain in experimental cystitis and prostatitis putatively by inhibition of PGE2 production (2016) (2)
- This information is current as Anti-Inflammatory Remedy Frankincense theFunctional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (2)
- A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. (2019) (2)
- Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. (2017) (2)
- Canephron N reduced immune cell recruitment in experimental cystitis (2017) (2)
- Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms (2022) (2)
- A combination of thyme and primula dry extracts possesses antitussive activity and inhibits leukotriene formation (2013) (1)
- A combination of thyme and ivy exerts potent anti-inflammatory and mucus-normalizing activity in vivo and inhibits 5-LO and PDE4 (2014) (1)
- In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway (2022) (1)
- Identification of LL-37 as a Molecular Target for Boswellic Acids (2009) (1)
- Upregulation of the 5-lipoxygenase pathway in human monocytes by growth and differentiation factors. (2013) (1)
- Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation. (2021) (1)
- Differential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytes. (2020) (1)
- Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition (2022) (1)
- Lipid droplets are required for lipid mediator production and cancer cell proliferation (2021) (1)
- Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides (2023) (1)
- 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae. (2021) (1)
- Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death (2019) (1)
- Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition (2022) (1)
- Design and Synthesis of Functionalized4-Aryl-Catechol Derivatives as New Anti-Inflammatory Agents with In Vivo Efficacy PART I (2022) (1)
- Benzylated dihydrochalcone MF-15 as a potent multitarget inhibitor of cancer cell growth (2021) (1)
- Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA (2019) (1)
- Label-Free Characterization of Macrophage Polarization Using Raman Spectroscopy (2023) (1)
- A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization. (2022) (1)
- Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization (2022) (1)
- Identification of 2,4‐Dinitro‐Biphenyl‐Based Compounds as MAPEG Inhibitors (2022) (1)
- Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases (2001) (0)
- Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase (2017) (0)
- The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria (2015) (0)
- The flavonolignan silibinin from Silybum marianum targets hepatic lipid biosynthesis and elevates the hepatic biotransformation capacity (2021) (0)
- 5-Lipoxygenase Pathway: A Validated Route to Drug Discovery (2011) (0)
- Using indole-3-carbonsäureestern for the inhibition of microsomal prostaglandin E2 synthase (2008) (0)
- Prenylated acylphloroglucinols from aerial parts of Hypericum scabrum (2022) (0)
- Abstract A49: Inhibition of adriamycin‐induced 5‐lipoxygenase in DU‐145 and PC3 prostate cancer cells confers cell death (2009) (0)
- Encapsulation of the anti-inflammatory dual FLAP/sEH inhibitor diflapolin improves the efficiency in human whole blood. (2021) (0)
- The Atlas of Inflammation Resolution (AIR). (2020) (0)
- Vitamin E metabolites as potent inhibitors of 5-lipoxygenase (2015) (0)
- Identification of multiple anti-inflammatory mechanisms and molecular targets of the herbal medicinal product Bronchipret® TP in vitro (2014) (0)
- Anti-Inflammatory Remedy Frankincense the Functional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (0)
- Preparations of myrtle, their ingredients and / or derivatives thereof for the treatment of cancers (2006) (0)
- Divergent effects of hyperforin on the release of arachidonic acid in human platelets and polymorphonuclear leukocytes (2008) (0)
- lipoxygenase in vivo and in vitro (2005) (0)
- Synbiotic Compositions of Bacillus megaterium and Polyunsaturated Fatty Acid Salt Enable Self-Sufficient Production of Specialized Pro-Resolving Mediators (2022) (0)
- P 048 – Garcinia kola – African ethno medication with anti-atherosclerotic effects? (2017) (0)
- P58 In vitro differentiation of human leukemic cell lines—a model for screening of drugs affecting the 5-lipoxygenase pathway (1994) (0)
- Long-chain metabolites of α-tocopherol emerge from the shadow of their precursors: Α-13’-OH and Α-13’-COOH as a new class of regulatory metabolites (2016) (0)
- Lipid droplets control mitogenic lipid mediator production in human cancer cells (2022) (0)
- The influence of placenta-conditioned medium on breast cancer cells (2016) (0)
- Recent Advances on 5‐Lipoxygenase Biochemistry (2014) (0)
- Vitex agnus-castus dry extract BNO 1095 (Cyclodynon®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea (2017) (0)
- Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. (2022) (0)
- Vitamin E Long-Chain Metabolite and the Inspired Drug Candidate Α-Amplexichromanol Relieve Asthma Features in an Experimental Model of Allergen Sensitization (2022) (0)
- Mitochondrial Chaperonin HSP 60 Is the Apoptosis-Related Target for Myrtucommulone Graphical Abstract Highlights (2017) (0)
- Small molecules inspired from endogenous vitamin E metabolites induce a lipid mediator class switch from inflammation to resolution in innate immune cells (2021) (0)
- Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties (2022) (0)
- Use of substances to protect the skin (2002) (0)
- Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes? (2015) (0)
- Plectranthus zeylanicus: A Rich Source of Secondary Metabolites with Antimicrobial, Disinfectant and Anti-Inflammatory Activities (2022) (0)
- Anti-Inflammatory Activities of Arnica montana Planta Tota versus Flower Extracts: Analytical, In Vitro and In Vivo Mouse Paw Oedema Model Studies (2023) (0)
- Frontispiece: Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans (2018) (0)
- The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional African medicine (2019) (0)
- Design and synthesis of functionalized 4-aryl-Catechol derivatives as new antinflammatory agents with in vivo efficacy. (2022) (0)
- Lupeolic acid derivatives from Boswellia species as inhibitors of the cytosolic phospholipase A2α (2010) (0)
- Impulse Lecture: Elucidation of the molecular basis of anti-inflammatory natural compounds from traditional medicinal plants (2010) (0)
- 3- O -Acetyl-11-keto-boswellic acid decreases basal intracellular Ca 2+ levels and inhibits agonist-induced Ca 2+ mobilisation and MAP kinase activation in human monocytic cells* (2005) (0)
- Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases (2001) (0)
- Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation (2022) (0)
- Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors (2023) (0)
- Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine (2022) (0)
- Coordinate functional regulation between microsomal prostaglandin E synthase-1 and PPARγ in the conversion of white-to-brown adipocytes* (2013) (0)
- Switching from inflammation to resolution: what can we learn from medicinal plants? (2021) (0)
- Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors (2022) (0)
- Anti-inflammatory depsides from Cetrelia monachorum potently targeting mPGES-1, 5-LO and NF-κB (2013) (0)
- Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase (2023) (0)
- Noha2015-BMC-non-acidic-mPGES1-inh (2015) (0)
- Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging (2021) (0)
- Ethoxy acetalated dextran nanoparticles for drug delivery: A comparative study of formulation methods (2023) (0)
- Rosmarinic acid as the effective compound in Cordia americana (2010) (0)
- Gender Medicine and Frankincense: Novel Findings in Inflammation Research (2009) (0)
- JPET #160663 1 The molecular pharmacology and in vivo activity of YS121 {2-(4-chloro-6-(2,3- dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid}, a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase* (2009) (0)
- Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization (2022) (0)
- Synthesis and structure–activity relationships for some novel diflapolin derivatives with benzimidazole subunit (2022) (0)
- Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis (2020) (0)
- Acronychia type acetophenones analogs inhibit 5-lipoxygenase (2014) (0)
- Boswellic acids from the anti-inflammatory remedy frankincense: Identification and functional analysis of novel molecular targets within the arachidonic acid cascacde (2008) (0)
- OP0151 Docosahexaenoic acid treatment of rheumatoid arthritis: a randomized, double-blind, placebo-controlled, cross-over study (2017) (0)
- N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE (2016) (0)
- Computational investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid (2019) (0)
- Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging. (2023) (0)
- Raman spectroscopic profiling of intracellular lipid compositions of macrophages induced in the vicinity of cancer cells (Conference Presentation) (2018) (0)
- Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation (2017) (0)
- Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis (2020) (0)
- Mediterranean Diet component oleic acid increases protective lipid-mediators and improves trabecular bone in a Porphyromonas-gingivalis-inoculation-model. (2022) (0)
- Bromoindirubins as novel chemotype for intervention with 5-lipoxygenase (2014) (0)
- 12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets. (2020) (0)
- (4R)-4-Hydroxy-1-[(2S)-2-hydroxydodecyl]-l-proline monohydrate (2006) (0)
- Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity (2018) (0)
- Introduction to the lipid mediators special issue. (2022) (0)
- Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase (2018) (0)
- Anti-viral and anti-inflammatory efficacies of Sinupret® dry extract BNO 1011 rationalise its therapeutic use in acute rhinosinusitis (2013) (0)
- Mycobacterium tuberculosis-Induced Prostaglandin J2 and 15-Deoxy-Prostaglandin J2 Inhibit Inflammatory Signals in Human M1 Macrophages via a Negative Feedback Loop. (2023) (0)
- Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract. (2023) (0)
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What Schools Are Affiliated With Oliver Werz?
Oliver Werz is affiliated with the following schools: