Oliver Werz

Oliver Werz's AcademicInfluence.com Rankings

Oliver Werz

Engineering

#5977

World Rank

#7265

Historical Rank

Biomedical Engineering

#489

World Rank

#499

Historical Rank

Applied Physics

#1840

World Rank

#1872

Historical Rank

engineering Degrees

Oliver Werz

Biology

#11047

World Rank

#14422

Historical Rank

Biotechnology

#175

World Rank

#177

Historical Rank

Molecular Biology

#1661

World Rank

#1689

Historical Rank

biology Degrees

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Engineering
Biology

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Oliver Werz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

5-Lipoxygenase: regulation of expression and enzyme activity. (2007) (439)
5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. (2015) (361)
The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes (*) (1995) (269)
Therapeutic options for 5-lipoxygenase inhibitors. (2006) (232)
Multi-target approach for natural products in inflammation. (2014) (222)
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. (2002) (221)
Boswellic acids: biological actions and molecular targets. (2006) (213)
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. (2000) (212)
5-lipoxygenase: cellular biology and molecular pharmacology. (2002) (194)
ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma (2008) (173)
Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity (2018) (171)
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. (2002) (166)
Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1 (2008) (156)
5-Lipoxygenase inhibitors: a review of recent developments and patents (2010) (154)
Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. (2007) (153)
Extracellular signal‐regulated kinases phosphorylate 5lipoxygenase and stimulate 5‐lipoxygenase product formation in leukocytes (2002) (148)
Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation. (2005) (141)
Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. (2008) (138)
Boswellia serrata (2011) (135)
Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents. (2011) (130)
Phosphorylation‐ and stimulus‐dependent inhibition of cellular 5‐lipoxygenase activity by nonredox‐type inhibitors (2003) (127)
Arachidonic Acid Promotes Phosphorylation of 5-Lipoxygenase at Ser-271 by MAPK-activated Protein Kinase 2 (MK2)* (2002) (122)
Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense (2011) (114)
Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review. (2009) (111)
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. (2012) (106)
Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1 (2009) (105)
Revealing the macromolecular targets of complex natural products. (2014) (104)
Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders. (2015) (102)
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9 (2007) (100)
The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages (2010) (99)
Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. (1996) (98)
Myrtucommulone from Myrtus communis Exhibits Potent Anti-Inflammatory Effectiveness in Vivo (2009) (96)
Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. (2008) (96)
Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds (2005) (96)
The 5-Lipoxygenase Promoter Is Regulated by DNA Methylation* (2002) (96)
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. (2008) (95)
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. (2007) (94)
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. (2009) (94)
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production (2006) (93)
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase (2018) (91)
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products (2020) (90)
Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. (2011) (87)
Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells (2006) (83)
Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes (2011) (82)
Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (2013) (82)
Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1 (2009) (81)
Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. (2001) (79)
Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1 (2012) (79)
Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. (2000) (76)
Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. (1998) (73)
Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense1 (2009) (71)
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products (2007) (71)
Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E2 Synthase-1 and Suppresses Prostaglandin E2 Formation in vivo (2010) (69)
Celecoxib inhibits 5-lipoxygenase. (2008) (69)
Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor γ (PPARγ) in the Conversion of White-to-brown Adipocytes* (2013) (67)
Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding (2013) (67)
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome (2019) (65)
The Atlas of Inflammation Resolution (AIR) (2020) (65)
Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (2014) (64)
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. (2009) (63)
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). (2009) (62)
Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. (2009) (62)
Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation (2017) (61)
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males (2017) (61)
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo (2009) (60)
Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase (2014) (59)
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. (2013) (59)
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. (2007) (59)
Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors. (2005) (59)
Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin. (2004) (59)
Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. (2001) (58)
Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro (2011) (56)
On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance. (2009) (56)
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins. (2013) (56)
Molecular pharmacological profile of the nonredox‐type 5‐lipoxygenase inhibitor CJ‐13,610 (2004) (55)
Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone. (2017) (54)
Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions. (2016) (54)
Coupling of boswellic acid‐induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes (2004) (53)
Small molecules intercept Notch signaling and the early secretory pathway. (2013) (53)
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity (2014) (53)
p38 MAP kinase mediates stress‐induced leukotriene synthesis in a human B‐lymphocyte cell line (2001) (53)
Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. (2009) (52)
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor. (2014) (52)
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. (2014) (52)
Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil. (2017) (51)
Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy. (2017) (49)
Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase‐1 Using Pharmacophore Models (2012) (49)
Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca2+ and Differentially Interact with Platelet-Type 12-Lipoxygenase (2006) (49)
Total synthesis of myrtucommulone A. (2010) (49)
α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. (2015) (48)
Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes (2016) (48)
Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1). (2014) (47)
The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5-Lipoxygenase (2010) (47)
Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors. (2015) (47)
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. (2002) (47)
Increased Bioavailability of 11‐Keto‐β‐Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures (2012) (46)
Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) (2011) (45)
On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo (2012) (45)
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor† †Electronic supplementary information (ESI) available: Supplementary figures, data and methods. See DOI: 10.1039/c8sc02634c (2018) (44)
Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. (2000) (44)
Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions (2017) (44)
Targeting de novo lipogenesis as a novel approach in anti-cancer therapy (2017) (40)
Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening (2016) (40)
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). (2012) (40)
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans (2020) (39)
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase. (2014) (39)
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase. (2006) (39)
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors. (2012) (39)
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX. (2012) (38)
1-Oleoyl-2-acetylglycerol Stimulates 5-Lipoxygenase Activity via a Putative (Phospho)lipid Binding Site within the N-terminal C2-like Domain* (2005) (38)
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. (2010) (38)
Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion (2015) (37)
In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis. (2014) (37)
SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction (2021) (37)
V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy (2016) (37)
High capacity for leukotriene biosynthesis in peripheral blood during pregnancy. (2013) (37)
Process control and scale-up of modified bacterial cellulose production for tailor-made anti-inflammatory drug delivery systems. (2020) (37)
Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis. (2018) (36)
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors. (2016) (36)
A test system for leukotriene synthesis inhibitors based on the in-vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6 (1997) (35)
Structure and biosynthetic assembly of gulmirecins, macrolide antibiotics from the predatory bacterium Pyxidicoccus fallax. (2014) (35)
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. (2015) (35)
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase (2017) (34)
An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis. (2014) (34)
Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman. (2015) (34)
5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation (2016) (33)
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). (2016) (33)
Purification of transforming growth factor beta 1 from human platelets. (1996) (33)
Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms (2019) (33)
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. (2013) (33)
Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction (2020) (33)
Identification of rosmarinic acid as the major active constituent in Cordia americana. (2010) (32)
The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP) (2014) (32)
The Aminosteroid Phospholipase C Antagonist U-73122 (1-[6-[[17-β-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) Potently Inhibits Human 5-Lipoxygenase in Vivo and in Vitro (2005) (31)
Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference. (2012) (31)
Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds (2005) (31)
Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening (2017) (31)
Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution (2020) (31)
Selective upregulation of TNF&agr; expression in classically‐activated human monocyte‐derived macrophages (M1) through pharmacological interference with V‐ATPase (2017) (31)
Role of p38 mitogen‐activated protein kinase in linking stearoyl‐CoA desaturase‐1 activity with endoplasmic reticulum homeostasis (2015) (31)
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly. (2016) (31)
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid. (2011) (31)
3-O-Acetyl-11-keto-boswellic Acid Decreases Basal Intracellular Ca2+ Levels and Inhibits Agonist-Induced Ca2+ Mobilization and Mitogen-Activated Protein Kinase Activation in Human Monocytic Cells (2006) (30)
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. (2005) (30)
Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum (2013) (29)
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. (2006) (29)
The Atlas of Inflammation-Resolution (AIR) (2020) (28)
Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria (2018) (28)
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR). (2014) (28)
Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase (2011) (27)
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? (2016) (27)
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. (2008) (27)
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents (2017) (27)
12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3* (2013) (27)
Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition[S] (2017) (27)
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations (2010) (27)
Myxochelins target human 5-lipoxygenase. (2015) (26)
The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria (2015) (26)
The C2-like β-Barrel Domain Mediates the Ca2+-dependent Resistance of 5-Lipoxygenase Activity Against Inhibition by Glutathione Peroxidase-1* (2003) (26)
Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase (2014) (26)
Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors. (2015) (26)
The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo. (2012) (26)
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils. (2011) (26)
Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis. (2015) (26)
The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. (2016) (26)
A Multicomponent Carba‐Betti Strategy to Alkylidene Heterodimers – Total Synthesis and Structure–Activity Relationships of Arzanol (2012) (25)
Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors (2016) (25)
Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases. (2005) (25)
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. (2005) (25)
Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death (2019) (24)
Induction of central signalling pathways and select functional effects in human platelets by β‐boswellic acid (2005) (24)
MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation. (2009) (24)
The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation. (2016) (24)
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors. (2015) (24)
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase. (2015) (24)
Cholesterol and its anionic derivatives inhibit 5‐lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells (2006) (24)
Discovery of new potent molecular entities able to inhibit mPGES-1. (2018) (23)
Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy (2017) (23)
Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout. (2018) (23)
The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response (2019) (23)
Phytochemical Profile of the Aerial Parts of Sedum sediforme and Anti-inflammatory Activity of Myricitrin (2015) (23)
Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. (2016) (23)
Chromatographic separation and biological evaluation of benzimidazole derivative enantiomers as inhibitors of leukotriene biosynthesis. (2014) (23)
Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol. (2003) (23)
Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach. (2014) (22)
Cell type‐dependent activation of 5‐lipoxygenase by arachidonic acid (2003) (22)
Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity (2018) (22)
Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5‐Lipoxygenase Inhibitors (2015) (22)
Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. (2017) (21)
Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum. (2014) (21)
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase. (2014) (21)
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. (2016) (20)
Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP. (2015) (20)
Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E. (2017) (20)
Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification (2016) (20)
The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5‐lipoxygenase in polymorphonuclear leukocytes (2008) (19)
Leukotriene‐mediated sex dimorphism in murine asthma‐like features during allergen sensitization (2019) (19)
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. (2019) (19)
A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2017) (19)
Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis (2019) (19)
NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum. (2017) (19)
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade"). (2016) (19)
Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study. (2016) (19)
The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains. (2017) (18)
Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones. (2006) (18)
Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy. (2019) (18)
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol (2015) (17)
Matrix‐based Molecular Descriptors for Prospective Virtual Compound Screening (2017) (17)
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening. (2017) (17)
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1. (2011) (17)
Simplified pretubulysin derivatives and their biological effects on cancer cells. (2014) (17)
Structure‐Based Design of Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors using a Virtual Fragment Growing Optimization Scheme (2016) (16)
A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2). (2012) (16)
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold. (2011) (16)
Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration (2013) (16)
Melleolides induce rapid cell death in human primary monocytes and cancer cells. (2014) (16)
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416. (2012) (16)
Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles. (2021) (15)
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. (2018) (15)
Determination of myrtucommulone from Myrtus communis in human and rat plasma by liquid chromatography/tandem mass spectrometry. (2011) (15)
Chemometrics-guided development of a cyclodextrin-modified micellar electrokinetic chromatography method with head-column field amplified sample stacking for the analysis of 5-lipoxygenase metabolites. (2012) (15)
Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation (2019) (15)
Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B. (2016) (15)
Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: the battle between pro- and anti-inflammatory lipid mediators. (2021) (14)
Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions. (2010) (14)
Development and Characterization of Bacterial Nanocellulose Loaded with Boswellia Serrata Extract Containing Nanoemulsions as Natural Dressing for Skin Diseases. (2020) (14)
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity (2020) (14)
Particulate transepithelial drug carriers: barriers and functional polymers (2012) (14)
Interference of Boswellic Acids with the Ligand Binding Domain of the Glucocorticoid Receptor (2014) (14)
Particulate transepithelial drug carriers: barriers and functional polymers (2012) (14)
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase. (2019) (14)
Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7. (2018) (14)
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered Myxococcus xanthus Strain. (2019) (14)
Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells (2020) (13)
Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G (2018) (13)
From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space (2012) (13)
The interplay between depression and tuberculosis (2019) (13)
Improved bioactivity of the natural product 5-lipoxygenase inhibitor hyperforin by encapsulation into polymeric nanoparticles. (2020) (13)
Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action. (2016) (12)
Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes. (2015) (12)
SAR studies of acidic dual γ-secretase/PPARγ modulators. (2011) (12)
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. (2021) (12)
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. (2019) (12)
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators. (2021) (12)
Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase. (2008) (12)
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections (2021) (12)
Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans. (2018) (12)
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. (2014) (12)
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design (2021) (12)
Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A. (2015) (12)
The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis. (2019) (12)
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. (2018) (12)
Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis (2019) (12)
Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37. (2015) (12)
Melleolides impact fungal translation via elongation factor 2. (2019) (11)
Diversity of Chromanol and Chromenol Structures and Functions: An Emerging Class of Anti-Inflammatory and Anti-Carcinogenic Agents (2020) (11)
Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice (2018) (11)
Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids. (2019) (11)
Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors (2015) (11)
ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids (2021) (11)
Associated Bacteria Affect Sexual Reproduction by Altering Gene Expression and Metabolic Processes in a Biofilm Inhabiting Diatom (2019) (11)
Extracellular signal-regulated kinase-2 phosphorylates RORα4 in vitro (2007) (11)
Myrtucommulone from Myrtus communis: Metabolism, Permeability, and Systemic Exposure in Rats (2012) (11)
Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1. (2012) (10)
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors. (2016) (10)
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase. (2019) (10)
Survey of the C20 and C22 oxylipin family in marine diatoms (2018) (10)
Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds (2020) (9)
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways. (2021) (9)
CyreneTM as an alternative sustainable solvent for the preparation of poly(lactic-co-glycolic acid) nanoparticles. (2020) (9)
Pharmacophore-based discovery of a novel cytosolic phospholipase A2α inhibitor (2012) (9)
Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction (2020) (9)
Olive Oil Extracts and Oleic Acid Attenuate the LPS-Induced Inflammatory Response in Murine RAW264.7 Macrophages but Induce the Release of Prostaglandin E2 (2021) (9)
Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1. (2014) (9)
5-Lipoxygenase activation by MAPKAPK-2 and ERKs. (2003) (9)
New vitamin D receptor agonists with decreased metabolic stability. (2000) (8)
5-Lipoxygenase: Regulation and Pharmacology (2004) (8)
A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors (2020) (8)
A Multi‐step Virtual Screening Protocol for the Identification of Novel Non‐acidic Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors (2018) (8)
Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. (2016) (8)
Evaluation of hyperforin analogues for inhibition of 5-lipoxygenase. (2005) (8)
Effect of Crystallinity on the Properties of Polycaprolactone Nanoparticles Containing the Dual FLAP/mPEGS-1 Inhibitor BRP-187 (2021) (8)
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. (2020) (8)
5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse. (2020) (8)
A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection. (2015) (8)
Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing (2021) (8)
Pirinixic acids: flexible fatty acid mimetics with various biological activities. (2015) (8)
Myxochelin‐Inspired 5‐Lipoxygenase Inhibitors: Synthesis and Biological Evaluation (2017) (8)
Hypertonicity suppresses ionophore‐induced product formation and translocation of 5‐lipoxygenase in human leukocytes (2002) (8)
A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. (2019) (8)
Modulation of microRNA processing by 5‐lipoxygenase (2020) (7)
Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination (2022) (7)
Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population. (2019) (7)
Regulation of inflammatory pathways by an a-tocopherol long-chain metabolite and a d-tocotrienol-related natural compound. (2014) (7)
Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro. (2007) (7)
The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka (2020) (7)
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones. (2017) (7)
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery (2021) (7)
Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201 (2022) (7)
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol (2020) (7)
Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels. (2020) (7)
Vitamin A regulates Akt signaling through the phospholipid fatty acid composition (2017) (6)
A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts (2018) (6)
Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics (2020) (6)
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages. (2021) (6)
pH-Dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin (1997) (6)
Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct. (2012) (6)
Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis (2020) (6)
Caulerpenyne and Related Bis‐enol Esters Are Novel‐Type Inhibitors of Human 5‐Lipoxygenase (2014) (6)
Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism (2019) (6)
Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol. (2018) (6)
Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides (2021) (6)
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation (2021) (6)
Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions (2020) (6)
A Thromboxane A2 Receptor-Driven COX-2–Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis (2022) (6)
Analysis of Boswellic Acid Contents and Related Pharmacological Activities of Frankincense-Based Remedies That Modulate Inflammation (2021) (6)
DNA methylation regulates 5-lipoxygenase promoter activity. (2003) (6)
Aging drives organ‐specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice (2021) (5)
Regulation of 5-lipoxygenase activity by selenium-dependent peroxidases-effects of transforming growth factor-beta and 1,25-dihydroxyvitamin D3. (1997) (5)
Sex Hormone–Dependent Lipid Mediator Formation in Male and Female Mice During Peritonitis (2022) (5)
Phorbol ester upregulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes (2001) (5)
The indirubin derivative 6-bromoindirubin-3'-glycerol-oxime ether (6BIGOE) potently modulates inflammatory cytokine and prostaglandin release from human monocytes through GSK-3 interference. (2020) (5)
Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors (2018) (5)
2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo (2011) (5)
Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea (2016) (5)
An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin. (2019) (5)
CHAPTER 1:Microsomal Prostaglandin E2 Synthase-1 (2012) (4)
Bioactivity and Mode of Action of Bacterial Tetramic Acids. (2019) (4)
Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts (2017) (4)
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution (2021) (4)
Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells (2022) (4)
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages. (2022) (4)
Candida albicans‐induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology (2021) (4)
The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages (2021) (4)
Separation of 5-Lipoxygenase Metabolites Using Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography and Head Column Field-Amplified Sample Stacking (2013) (4)
Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. (2022) (4)
Macrophage-targeting oligopeptides from Mortierella alpina (2022) (4)
The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators (2021) (4)
Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent. (2002) (4)
The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. (2021) (4)
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy. (2021) (4)
A selective modulator of peroxisome proliferator-activated receptor γ with unprecedented binding mode. (2020) (4)
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. (2015) (4)
15‐Hydroperoxy‐PGE2: Intermediate in Mammalian and Algal Prostaglandin Biosynthesis (2019) (3)
Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation (2022) (3)
Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583] (2015) (3)
Discovery of N-Amido-Phenylsulfonamide Derivatives as Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. (2021) (3)
The aminosteroid phospholipase C antagonist U-73122 potently inhibits human 5-lipoxygenase in vivo and in vitro * (2005) (3)
Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis (2020) (3)
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood (2021) (3)
Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care (2022) (3)
Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. (2009) (3)
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors (2022) (2)
Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition (2021) (2)
A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum (2015) (2)
In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum (2010) (2)
Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model (2021) (2)
Drug delivery of 6-bromoindirubin-3’-glycerol-oxime ether employing poly(d,l-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents (2022) (2)
Staphylococcus aureus controls eicosanoid and specialized pro‐resolving mediator production via lipoteichoic acid (2022) (2)
Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy (2020) (2)
262 Canephron® N reduces pain in experimental cystitis and prostatitis putatively by inhibition of PGE2 production (2016) (2)
This information is current as Anti-Inflammatory Remedy Frankincense theFunctional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (2)
A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. (2019) (2)
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. (2017) (2)
Canephron N reduced immune cell recruitment in experimental cystitis (2017) (2)
Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms (2022) (2)
A combination of thyme and primula dry extracts possesses antitussive activity and inhibits leukotriene formation (2013) (1)
A combination of thyme and ivy exerts potent anti-inflammatory and mucus-normalizing activity in vivo and inhibits 5-LO and PDE4 (2014) (1)
In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway (2022) (1)
Identification of LL-37 as a Molecular Target for Boswellic Acids (2009) (1)
Upregulation of the 5-lipoxygenase pathway in human monocytes by growth and differentiation factors. (2013) (1)
Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation. (2021) (1)
Differential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytes. (2020) (1)
Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition (2022) (1)
Lipid droplets are required for lipid mediator production and cancer cell proliferation (2021) (1)
Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides (2023) (1)
14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae. (2021) (1)
Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death (2019) (1)
Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition (2022) (1)
Design and Synthesis of Functionalized4-Aryl-Catechol Derivatives as New Anti-Inflammatory Agents with In Vivo Efficacy PART I (2022) (1)
Benzylated dihydrochalcone MF-15 as a potent multitarget inhibitor of cancer cell growth (2021) (1)
Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA (2019) (1)
Label-Free Characterization of Macrophage Polarization Using Raman Spectroscopy (2023) (1)
A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization. (2022) (1)
Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization (2022) (1)
Identification of 2,4‐Dinitro‐Biphenyl‐Based Compounds as MAPEG Inhibitors (2022) (1)
Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases (2001) (0)
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase (2017) (0)
The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria (2015) (0)
The flavonolignan silibinin from Silybum marianum targets hepatic lipid biosynthesis and elevates the hepatic biotransformation capacity (2021) (0)
5-Lipoxygenase Pathway: A Validated Route to Drug Discovery (2011) (0)
Using indole-3-carbonsäureestern for the inhibition of microsomal prostaglandin E2 synthase (2008) (0)
Prenylated acylphloroglucinols from aerial parts of Hypericum scabrum (2022) (0)
Abstract A49: Inhibition of adriamycin‐induced 5‐lipoxygenase in DU‐145 and PC3 prostate cancer cells confers cell death (2009) (0)
Encapsulation of the anti-inflammatory dual FLAP/sEH inhibitor diflapolin improves the efficiency in human whole blood. (2021) (0)
The Atlas of Inflammation Resolution (AIR). (2020) (0)
Vitamin E metabolites as potent inhibitors of 5-lipoxygenase (2015) (0)
Identification of multiple anti-inflammatory mechanisms and molecular targets of the herbal medicinal product Bronchipret® TP in vitro (2014) (0)
Anti-Inflammatory Remedy Frankincense the Functional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (0)
Preparations of myrtle, their ingredients and / or derivatives thereof for the treatment of cancers (2006) (0)
Divergent effects of hyperforin on the release of arachidonic acid in human platelets and polymorphonuclear leukocytes (2008) (0)
lipoxygenase in vivo and in vitro (2005) (0)
Synbiotic Compositions of Bacillus megaterium and Polyunsaturated Fatty Acid Salt Enable Self-Sufficient Production of Specialized Pro-Resolving Mediators (2022) (0)
P 048 – Garcinia kola – African ethno medication with anti-atherosclerotic effects? (2017) (0)
P58 In vitro differentiation of human leukemic cell lines—a model for screening of drugs affecting the 5-lipoxygenase pathway (1994) (0)
Long-chain metabolites of α-tocopherol emerge from the shadow of their precursors: Α-13’-OH and Α-13’-COOH as a new class of regulatory metabolites (2016) (0)
Lipid droplets control mitogenic lipid mediator production in human cancer cells (2022) (0)
The influence of placenta-conditioned medium on breast cancer cells (2016) (0)
Recent Advances on 5‐Lipoxygenase Biochemistry (2014) (0)
Vitex agnus-castus dry extract BNO 1095 (Cyclodynon®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea (2017) (0)
Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation. (2022) (0)
Vitamin E Long-Chain Metabolite and the Inspired Drug Candidate Α-Amplexichromanol Relieve Asthma Features in an Experimental Model of Allergen Sensitization (2022) (0)
Mitochondrial Chaperonin HSP 60 Is the Apoptosis-Related Target for Myrtucommulone Graphical Abstract Highlights (2017) (0)
Small molecules inspired from endogenous vitamin E metabolites induce a lipid mediator class switch from inflammation to resolution in innate immune cells (2021) (0)
Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties (2022) (0)
Use of substances to protect the skin (2002) (0)
Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes? (2015) (0)
Plectranthus zeylanicus: A Rich Source of Secondary Metabolites with Antimicrobial, Disinfectant and Anti-Inflammatory Activities (2022) (0)
Anti-Inflammatory Activities of Arnica montana Planta Tota versus Flower Extracts: Analytical, In Vitro and In Vivo Mouse Paw Oedema Model Studies (2023) (0)
Frontispiece: Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans (2018) (0)
The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional African medicine (2019) (0)
Design and synthesis of functionalized 4-aryl-Catechol derivatives as new antinflammatory agents with in vivo efficacy. (2022) (0)
Lupeolic acid derivatives from Boswellia species as inhibitors of the cytosolic phospholipase A2α (2010) (0)
Impulse Lecture: Elucidation of the molecular basis of anti-inflammatory natural compounds from traditional medicinal plants (2010) (0)
3- O -Acetyl-11-keto-boswellic acid decreases basal intracellular Ca 2+ levels and inhibits agonist-induced Ca 2+ mobilisation and MAP kinase activation in human monocytic cells* (2005) (0)
Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases (2001) (0)
Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation (2022) (0)
Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors (2023) (0)
Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine (2022) (0)
Coordinate functional regulation between microsomal prostaglandin E synthase-1 and PPARγ in the conversion of white-to-brown adipocytes* (2013) (0)
Switching from inflammation to resolution: what can we learn from medicinal plants? (2021) (0)
Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors (2022) (0)
Anti-inflammatory depsides from Cetrelia monachorum potently targeting mPGES-1, 5-LO and NF-κB (2013) (0)
Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase (2023) (0)
Noha2015-BMC-non-acidic-mPGES1-inh (2015) (0)
Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging (2021) (0)
Ethoxy acetalated dextran nanoparticles for drug delivery: A comparative study of formulation methods (2023) (0)
Rosmarinic acid as the effective compound in Cordia americana (2010) (0)
Gender Medicine and Frankincense: Novel Findings in Inflammation Research (2009) (0)
JPET #160663 1 The molecular pharmacology and in vivo activity of YS121 {2-(4-chloro-6-(2,3- dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid}, a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase* (2009) (0)
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization (2022) (0)
Synthesis and structure–activity relationships for some novel diflapolin derivatives with benzimidazole subunit (2022) (0)
Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis (2020) (0)
Acronychia type acetophenones analogs inhibit 5-lipoxygenase (2014) (0)
Boswellic acids from the anti-inflammatory remedy frankincense: Identification and functional analysis of novel molecular targets within the arachidonic acid cascacde (2008) (0)
OP0151 Docosahexaenoic acid treatment of rheumatoid arthritis: a randomized, double-blind, placebo-controlled, cross-over study (2017) (0)
N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE (2016) (0)
Computational investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid (2019) (0)
Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging. (2023) (0)
Raman spectroscopic profiling of intracellular lipid compositions of macrophages induced in the vicinity of cancer cells (Conference Presentation) (2018) (0)
Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation (2017) (0)
Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis (2020) (0)
Mediterranean Diet component oleic acid increases protective lipid-mediators and improves trabecular bone in a Porphyromonas-gingivalis-inoculation-model. (2022) (0)
Bromoindirubins as novel chemotype for intervention with 5-lipoxygenase (2014) (0)
12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets. (2020) (0)
(4R)-4-Hydroxy-1-[(2S)-2-hydroxydodecyl]-l-proline monohydrate (2006) (0)
Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity (2018) (0)
Introduction to the lipid mediators special issue. (2022) (0)
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase (2018) (0)
Anti-viral and anti-inflammatory efficacies of Sinupret® dry extract BNO 1011 rationalise its therapeutic use in acute rhinosinusitis (2013) (0)
Mycobacterium tuberculosis-Induced Prostaglandin J2 and 15-Deoxy-Prostaglandin J2 Inhibit Inflammatory Signals in Human M1 Macrophages via a Negative Feedback Loop. (2023) (0)
Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract. (2023) (0)

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What Schools Are Affiliated With Oliver Werz?

Oliver Werz is affiliated with the following schools:

Goethe University Frankfurt
University of Jena
Karolinska Institute

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What Schools Are Affiliated With Oliver Werz?

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