Osamu Hayaishi

Q: What Schools Are Affiliated With Osamu Hayaishi

Osamu Hayaishi is affiliated with the following schools: Osaka Medical and Pharmaceutical University, University of California, Berkeley, Kyushu University, University of Tokyo, Shiga University of Medical Science, Osaka University, Kyoto University

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Osamu Hayaishi

Biology

#178

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#326

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Biochemistry

#38

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#51

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Biology

Osamu Hayaishi's Degrees

PhD Biochemistry Osaka University

Why Is Osamu Hayaishi Influential?

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According to Wikipedia, Osamu Hayaishi MJA, was a Japanese biochemist, physiologist, and military physician. He discovered Oxygenases at the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health in 1955.

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Osamu Hayaishi's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Advances in Prostaglandin, Thromboxane, and Leukotriene Research (1985) (627)
Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. (1976) (591)
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine (2005) (569)
Arousal effect of orexin A depends on activation of the histaminergic system (2001) (532)
Molecular mechanisms of oxygen activation (1974) (515)
Poly(ADP-ribose) and ADP-ribosylation of proteins. (1977) (493)
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. (1968) (421)
Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. (1986) (353)
Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. (2000) (328)
Indoleamine 2,3-dioxygenase. Purification and some properties. (1978) (326)
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. (1979) (321)
In vitro and in vivo formation of two new metabolites of melatonin. (1974) (296)
The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine. (1965) (288)
Prostaglandin D synthase: structure and function. (2000) (286)
MECHANISM OF THE PYROCATECHASE REACTION (1955) (283)
Enzymic studies on the biosynthesis of serotonin in mammalian brain. (1970) (275)
Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. (1988) (269)
Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. (1981) (260)
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase (1997) (260)
Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei. (1967) (251)
Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens (2011) (243)
Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D2 and E2 (1991) (241)
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons (2001) (236)
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. (1999) (232)
Purification and characterization of rat brain prostaglandin D synthetase. (1985) (227)
Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. (1993) (225)
Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. (1979) (219)
The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. (1989) (217)
Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes. (1967) (214)
Lipocalin-type Prostaglandin D Synthase (β-Trace) Is a Newly Recognized Type of Retinoid Transporter* (1997) (206)
Prostaglandins and adenosine in the regulation of sleep and wakefulness. (2007) (198)
Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. (1983) (190)
Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. (1982) (189)
Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei. (1981) (189)
Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme. (1977) (188)
Metapyrocatachase: a new catechol-cleaving enzyme. (1961) (187)
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. (1991) (187)
ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites. (1980) (182)
Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization. (1972) (181)
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep (2001) (180)
Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. (1986) (179)
The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus (2005) (178)
Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2α to conscious mice (1990) (177)
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. I. PURIFICATION AND GENERAL PROPERTIES. (1965) (174)
STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. I. ENZYMIC SYNTHESIS OF NIACIN RIBONUCLEOTIDES FROM 3-HYDROXYANTHRANILIC ACID IN MAMMALIAN TISSUES. (1963) (173)
STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS. (1965) (170)
The role of adenosine in the regulation of sleep. (2011) (169)
Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. (2006) (167)
Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. (1997) (167)
Prostaglandin D2 and sleep regulation. (1999) (165)
Biological Rhythms and Their Central Mechanism (1979) (161)
Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. (1996) (161)
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. (1998) (160)
Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide. (1978) (156)
Prostaglandin D2 and sleep/wake regulation. (2011) (155)
Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. (1982) (153)
Regional Distribution of Prostaglandins D2, E2, and F2α and Related Enzymes in Postmortem Human Brain (1984) (150)
Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. (1982) (149)
ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. (1980) (149)
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep (2006) (142)
9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. (1984) (142)
Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose). (1986) (142)
Sleep-wake regulation by prostaglandins D2 and E2. (1988) (140)
Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase. (1981) (139)
Studies on oxygenases; pyrocatechase. (1957) (138)
Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. (1968) (136)
Increased level of salivary prostaglandins in patients with major depression (1988) (136)
Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. (1988) (136)
Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate. (1975) (136)
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. (1971) (134)
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. (1985) (132)
Identification of beta-trace as prostaglandin D synthase. (1994) (131)
Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. (1994) (128)
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep (2008) (127)
Prostaglandin D2: a biochemical perspective. (1989) (126)
Poly ADP-ribose glycohydrolase from rat liver nuclei, a novel enzyme degrading the polymer. (1972) (126)
Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. (1994) (125)
Allodynia evoked by intrathecal administration of prostaglandin F2α to conscious mice (1992) (124)
High density of prostaglandin E2 binding sites in the anterior wall of the 3rd ventricle: a possible site of its hyperthermic action (1990) (124)
Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. (1988) (124)
Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. (1981) (124)
Properties and function of indoleamine 2,3-dioxygenase. (1976) (123)
6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain. (1985) (123)
Indoleamine 2,3-dioxygenase. (1982) (123)
Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins. (1978) (123)
Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. (1999) (121)
ADP-ribosyl protein lyase. Purification, properties, and identification of the product. (1984) (121)
Studies on oxygenases; enzymatic formation of kynurenine from tryptophan. (1957) (121)
Nature and mechanisms of oxygenases. (1969) (120)
Characterization of EP‐receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice (1994) (119)
Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. (1987) (118)
Mast cells contain spleen-type prostaglandin D synthetase. (1990) (118)
Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. (2000) (117)
Prostaglandin D2, a neuromodulator. (1979) (116)
An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats (2005) (115)
Allosteric properties of nucleoside diphosphatase and its identity with thiamine pyrophosphatase. (1968) (115)
Region‐dependent difference in the sleep‐promoting potency of an adenosine A2A receptor agonist (1999) (114)
THE BACTERIAL OXIDATION OF TRYPTOPHAN III (1951) (113)
Prostaglandin D2, a potential antineoplastic agent. (1982) (112)
Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets. (1977) (110)
Prostaglandin D, E, and F synthases. (1995) (109)
Firing of neurons in the preoptic/anterior hypothalamic areas in rat: its possible involvement in slow wave sleep and paradoxical sleep (1994) (108)
Prostaglandin D2 in Sleep-Wake Regulation: Recent Progress and Perspectives (2002) (105)
Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. (1980) (105)
Purification and properties of prostaglandin D synthetase from rat brain. (1979) (104)
Identification of a Novel Prostaglandin F2α Synthase in Trypanosoma brucei (2000) (104)
Enzymic formation of D-kynurenine from D-tryptophan. (1967) (103)
Involvement of adenosine A2A receptor in sleep promotion. (1998) (101)
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. (2000) (101)
Identification of Mu-Class Glutathione Transferases M2-2 and M3-3 as Cytosolic Prostaglandin E Synthases in the Human Brain (2000) (99)
Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. (1998) (98)
Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. (1967) (97)
Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide. (1966) (97)
Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes. (1952) (96)
Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. (1984) (96)
9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. (1982) (96)
Minireview: Sleep regulation in adenosine A2A receptor-deficient mice (2003) (95)
Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner. (1989) (94)
Metapyrocatechase. II. The role of iron and sulfhydryl groups. (1968) (94)
On the submitochondrial localization of l-kynurenine-3-hydroxylase. (1967) (93)
Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases. (1997) (93)
Natural occurrence of poly(ADP-ribosyl) histones in rat liver. (1975) (93)
Studies on pyrocatechase. I. Purification and spectral properties. (1967) (93)
CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats (1997) (91)
Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex. (1977) (91)
The oxygenated form of L-tryptophan 2,3-dioxygenase as reaction intermediate. (1970) (90)
Enzymatic studies on the metabolism of beta-alanine. (1961) (90)
Prostaglandin synthetase system--resolution into oxygenase and isomerase components. (1974) (90)
Suppression of Prostaglandin E Receptor Signaling by the Variant Form of EP1 Subtype* (1996) (89)
Purification and some properties of protocatechuate 4,5-dioxygenase. (1970) (89)
Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. (2002) (88)
Primary Structure of Rat Brain Prostaglandin D Synthetase Deduced from the cDNA Sequence (1989) (88)
Salivary prostaglandin concentrations: possible state indicators for major depression. (1989) (88)
Indoleamine 2,3-dioxygenase. Equilibrium studies of the tryptophan binding to the ferric, ferrous, and CO-bound enzymes. (1980) (87)
Plasmodium falciparum Produces Prostaglandins that are Pyrogenic, Somnogenic, and Immunosuppressive Substances in Humans (1998) (87)
New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase. (1972) (87)
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice (1994) (87)
A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acid. (1991) (86)
Choroid plexus: the major site of mRNA expression for the β-trace protein (prostaglandin D synthase) in human brain (1996) (83)
Purification and properties of poly(adenosine diphosphate ribose) synthetase. (1977) (83)
Possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction. (1971) (82)
Adenyl cyclase of Brevibacterium liquefaciens. (1967) (82)
Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain. (1987) (82)
Structural organization of the gene for prostaglandin D synthase in the rat brain. (1992) (81)
Enzymatic decarboxylation of oxalic acid. (1955) (81)
Activation of DNA ligase by poly(ADP-ribose) in chromatin. (1983) (80)
Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. (2002) (80)
Biochemical and medical aspects of tryptophan metabolism. (1980) (80)
Purification and characterization of poly(ADP-ribose) synthetase from calf thymus. (1979) (80)
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID. (1965) (79)
Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase. (1991) (78)
Lipocalin-Type Prostaglandin D Synthase (β-Trace) Is Located in Pigment Epithelial Cells of Rat Retina and Accumulates within Interphotoreceptor Matrix (1996) (78)
Prostaglandin D Synthase (β-Trace) in Human Arachnoid and Meningioma Cells: Roles as a Cell Marker or in Cerebrospinal Fluid Absorption, Tumorigenesis, and Calcification Process (1997) (78)
Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F 2α injected into conscious mice (1994) (76)
Indoleamine 2,3-dioxygenase: incorporation of 18O2-- and 18O2 into the reaction products. (1977) (75)
Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. (1982) (75)
Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis. (1984) (74)
The preparation and properties of a soluble diphosphopyridine nucleotide cytochrome c reductase. (1952) (74)
Prostaglandin E receptor enhancement of catecholamine release may be mediated by phosphoinositide metabolism in bovine adrenal chromaffin cells. (1988) (74)
PYROCATECASE A NEW ENZYME CATALIZING OXIDATIVE BREAKDOWN OF PYROCATECHIN (1950) (73)
Poly(ADP-ribose) synthetase. (1984) (72)
Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol. (1959) (72)
Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. (1996) (72)
Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine. (1957) (71)
Telencephalon-specific antigen identified by monoclonal antibody. (1987) (71)
A superfamily of NADPH-dependent reductases in eukaryotes and prokaryotes. (1989) (71)
Metabolism of phospholipides by bacterial enzymes. (1954) (70)
Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives. (1984) (70)
Enzymic adenosine diphosphoribosylation of nuclear proteins. (1969) (69)
Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. (2004) (69)
Tryptophan-5-hydroxylase in mammalian brain. (1968) (69)
Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds. (1991) (68)
Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. (1982) (68)
Expression of mRNA encoding the prostaglandin F2 alpha receptor in bovine corpora lutea throughout the oestrous cycle and pregnancy. (1995) (67)
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. II. THE MECHANISM OF SALICYLATE HYDROXYLATION TO CATECHOL. (1965) (67)
Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. (1986) (65)
Adp-Ribosylation Reactions: Biology and Medicine (1982) (65)
Extradiol cleavage of 3-substituted catechols by an intradiol dioxygenase, pyrocatechase, from a Pseudomonad. (1975) (65)
Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain. (1968) (65)
Novel enzyme from rat liver that cleaves an ADP-ribosyl histone linkage. (1978) (65)
Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. (1982) (63)
Prostaglandin D2, a cerebral sleep-inducing substance in rats. (1983) (61)
Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. (2000) (61)
Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord (1995) (61)
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation. (1996) (61)
Prostaglandin E2 Activates the Histaminergic System via the EP4 Receptor to Induce Wakefulness in Rats (2003) (61)
Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. (1978) (60)
THE BACTERIAL OXIDATION OF TRYPTOPHAN I (1951) (60)
Indoleamine 2,3-dioxygenase. Kinetic studies on the binding of superoxide anion and molecular oxygen to enzyme. (1979) (57)
Quantitative autoradiographic localization of prostaglandin E2 binding sites in monkey diencephalon (1988) (57)
Snake venom phosphodiesterase: simple purification with Blue Sepharose and its application to poly(ADP-ribose) study. (1978) (57)
Awaking effect of prostaglandin E2 in freely moving rats (1989) (57)
Specific induction of indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide in the mouse lung. (1981) (56)
Iron and Copper Proteins (1976) (55)
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2α in conscious mice (1995) (54)
Immunohistochemical demonstration of poly(adenosine diphosphate-ribose) in nuclei of various rat tissues. (1980) (54)
Poly adenosine diphosphate ribose synthesis associated with chromatin. (1968) (54)
The Excretion of Imidazoleacetic Acid Riboside Following the Administration of Imidazoleacetic Acid Or Histamine To Rats1 (1955) (53)
METAPYROCATECHASE. I. PURIFICATION, CRYSTALLIZATION AND SOME PROPERTIES. (1963) (53)
Purification of ADP-ribosylated nuclear proteins by covalent chromatography on dihydroxyboryl polyacrylamide beads and their characterization. (1978) (52)
Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. (1986) (52)
Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats. (1994) (52)
ADP-ribosylation reactions. (1982) (52)
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. (1996) (51)
Urocanic acid as an intermediate in the enzymatic conversion of histidine to glutamic and formic acids. (1952) (51)
Monoclonal antibody R2D5 reveals midsagittal radial glial system in postnatally developing and adult brainstem. (1990) (51)
Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. (1983) (51)
Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. (1987) (50)
Protocatechuate 3,4-dioxygenase. II. Electron spin resonance and spectral studies on interaction of substrates and enzyme. (1972) (50)
Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes (1998) (50)
Interferon: a mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly(I) X poly(C), and pokeweed mitogen in mouse lung. (1986) (49)
Characterization of the Unfolding Process of Lipocalin-type Prostaglandin D Synthase* (2003) (49)
Stereospecificity of hepatic L-tryptophan 2,3-dioxygenase. (1980) (49)
Intracellular utilization of superoxide anion by indoleamine 2,3-dioxygenase of rabbit enterocytes. (1977) (49)
Prostaglandin F2α Receptor Is Coupled to Gq in cDNA-transfected Chinese Hamster Ovary Cells (1994) (48)
Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. (1996) (48)
Central action of prostaglandin E2 and its methyl ester in the induction of hyperthermia after their systemic administration in urethane-anesthetized rats. (1988) (48)
Initiation of poly(ADP-ribosyl) histone synthesis by poly(ADP-ribose) synthetase. (1980) (48)
ENZYMATIC FORMATION OF OXALATE AND ACETATE FROM OXALOACETATE (1956) (47)
Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain (1991) (47)
Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. (1995) (47)
Distinct localization of prostaglandin D2, E2, and F2α binding sites in monkey brain (1989) (45)
Adenylate cyclase from Brevibacterium liquefaciens. I. Purification, crystallization, and some properties. (1974) (45)
Transport of prostaglandin D2 into brain (1986) (45)
The bacterial oxidation of tryptophan; a study in comparative biochemistry. (1951) (44)
My life with tryptophan—Never a dull moment (1993) (44)
Purification and characterization of prostaglandin F synthase from bovine liver. (1992) (44)
Enzymic formation of lactobionic acid from lactose. (1962) (44)
Isolation of an activator for prostaglandin hydroperoxidase from bovine vesicular gland cytosol and its identification as uric acid. (1979) (44)
Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. (1983) (44)
Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. (1989) (43)
Indoleamine 2,3-dioxygenase. Formation of L-kynurenine from L-tryptophan in cultured rabbit fineal gland. (1978) (43)
Quinolinic acid: a precursor to nicotinamide adenine dinucleotide in Escherichia coli. (1963) (43)
Prostaglandin E2 exerts an awaking effect in the posterior hypothalamus at a site distinct from that mediating its febrile action in the anterior hypothalamus (1992) (43)
Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice (1995) (43)
An NADP-linked prostaglandin D dehydrogenase in swine brain. (1980) (42)
Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation. (1980) (42)
Inhibition of interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung by inhibitors of prostaglandin biosynthesis. (1981) (42)
Prostaglandin D Synthase in Human Megakaryoblastic Cells* (1997) (42)
Pyruvate dependent adenyl cyclase activity of Brevibacterium liquefaciens. (1965) (42)
Purification and characterization of rho-crystallin from Japanese common bullfrog lens. (1990) (41)
Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. (1998) (40)
Poly(ADP-ribosy)ation of nuclear proteins. Enzymatic elongation of chemically synthesized ADP-ribose-histone adducts. (1979) (40)
S-Alkylcysteinase: Enzymatic Cleavage of S-Methyl-l-cysteine and Its Sulfoxide (1963) (40)
Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. (1998) (40)
Brain-type prostaglandin D synthetase occurs in the rat cochlea. (1987) (40)
Crystalline oxygenases of pseudomonads. (1966) (40)
METABOLIC AND FUNCTIONAL SIGNIFICANCE OF PROSTAGLANDINS IN LIPID PEROXIDE RESEARCH (1982) (40)
Molecular mechanism of sleep regulation by prostaglandin D2. (1996) (40)
Crystalline L-lysine oxygenase. (1966) (39)
Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein. (1987) (39)
ENZYMATIC OXYGEN FIXATION INTO ACETATE CONCOMITANT WITH THE ENZYMATIC DECARBOXYLATION OF L-LACTATE (1957) (38)
A new metabolic pathway of tryptophan initiated by tryptophan side chain oxidase. (1979) (38)
Flavin adenine dinucleotide requirement for the enzymic hydroxylation and decarboxylation of salicylic acid. (1962) (38)
Hypothyroidism Alters the Expression of Prostaglandin D2 Synthase/β‐ Trace in Specific Areas of the Developing Rat Brain (1997) (37)
1 – GENERAL PROPERTIES AND BIOLOGICAL FUNCTIONS OF OXYGENASES (1974) (37)
Prostaglandin D2 reduces intraocular pressure. (1988) (37)
Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats (1984) (36)
NUCLEOTIDE ACTIVATION OF THREONINE DEAMINASE FROM ESCHERICHIA COLI. (1965) (36)
Enzymic synthesis of niacin nucleotides from 3-hydroxyanthranilic acid in mammalian liver. (1963) (36)
Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria. (1967) (36)
Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid. (1963) (35)
Structural Basis of the Catalytic Mechanism Operating in Open-Closed Conformers of Lipocalin Type Prostaglandin D Synthase* (2009) (35)
Evidence for an oxygenated intermediate in the tryptophan pyrrolase reaction. (1967) (35)
Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. (1992) (35)
Specific bindings of prostaglandin D2, E2 and F2α in postmortem human brain (1985) (35)
ADP-ribosylation of nuclear protein A24. (1978) (34)
Enhancement of lipocalin-type prostaglandin D synthase enzyme activity by guanidine hydrochloride. (1999) (34)
On the equilibrium of the adenylate cyclase reaction. (1971) (34)
Activation mechanism of prostaglandin endoperoxide synthetase by hemoproteins. (1982) (34)
Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase (1988) (33)
Prostaglandin D2 is crucial for seizure suppression and postictal sleep (2014) (33)
Therapeutic Effect of Tetrahydrobiopterin in Infantile Autism (1987) (33)
Crystallization and some properties of metapyrocatechase. (1963) (33)
Studies on the interaction between regulatory enzymes and effectors. II. Effect of adenosine 5'-monophosphate analogues on glycogen phosphorylase B. (1968) (33)
An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. (1982) (33)
A bacterial pterin deaminase. (1959) (32)
Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lung. (1989) (32)
The kynureninase of Pseudomonas fluorescens. (1952) (32)
REM sleep-associated hemoglobin oxygenation in the monkey forebrain studied using near-infrared spectrophotometry (1991) (31)
Purification and properties of nucleoside hydrolase from Pseudomonas fluorescens. (1967) (31)
Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. (1968) (31)
Sttudies on pyrocatechase. II. Electron spin resonance and other properties of iron in the active center. (1969) (31)
Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. (1988) (31)
Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats (1994) (31)
Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase. (1969) (31)
Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. (1986) (31)
Association of poly ADP-ribose glycohydrolase with liver chromatin. (1972) (31)
Strong rebound of wakefulness follows prostaglandin D2‐ or adenosine A2a receptor agonist‐induced sleep (2000) (30)
Enzymatic degradation of beta-ketoadipic acid. (1957) (30)
ENZYMATIC FORMATION OF BARBITURIC ACID FROM URACIL AND OF 5-METHYLBARBITURIC ACID FROM THYMINE (1951) (30)
Solubilization and Characterization of Prostaglandin E2 Binding Protein from Porcine Cerebral Cortex (1986) (30)
ENZYMIC STUDIES ON THE METABOLISM OF GLUTARATE IN PSEUDOMONAS. (1964) (30)
Changes of Enzymes Involved in Prostaglandin Metabolism and Prostaglandin Binding Proteins in Rat Brain During Development and Aging (1985) (30)
Does Fourier-transform infrared spectroscopy provide useful information on protein structures? (1992) (29)
Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep. (2003) (29)
[58] Metabolism of the benzene ring of tryptophan (mammals) (1970) (28)
Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats (1988) (28)
Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study (1995) (28)
Monooxygenase activities of dioxygenases. Benzphetamine demethylation and aniline hydroxylation reactions catalyzed by indoleamine 2,3-dioxygenase. (1983) (28)
Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells. (1987) (28)
Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats (1993) (28)
The enzymatic conversion of histidine to glutamic acid. (1952) (28)
Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. (1969) (28)
Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. (1988) (27)
[26] Indoleamine 2,3-dioxygenase (1987) (27)
A new metabolic pathway of catechol. (1962) (27)
Quantitative Sandwich Enzyme-linked Immunosorbent Assay for Human Secretory Prostaglandin D Synthase (.BETA.-Trace). (1996) (27)
Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye. (1981) (27)
History and Scope (1962) (27)
Type‐1 and type‐2 astrocytes are distinct targets for prostaglandins D2, E2, and F2α (1992) (27)
Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors. (1969) (27)
9 alpha,11 beta-prostaglandin F2 formation in various bovine tissues. Different isozymes of prostaglandin D2 11-ketoreductase, contribution of prostaglandin F synthetase and its cellular localization. (1990) (26)
Elevated CSF histamine levels in multiple sclerosis patients (2013) (26)
Chapter 1 – Poly- and Mono(ADP-ribosyl)ation Reactions: Their Significance in Molecular Biology (1982) (26)
Enzymatic ADP-ribosylation of proteins and regulation of cellular activity. (1973) (26)
Prostaglandins and sleep. (1995) (25)
Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. (1986) (25)
[108] Kynurenine hydroxylase: L-Kynurenine + TPNH + H+ + O2 → 3-Hydroxy-L-kynurenine + TPN + H2O (1962) (25)
Allodynia evoked by intrathecal administration of prostaglandin F2 alpha to conscious mice. (1992) (25)
Involvement of protein kinase C in prostaglandin E2-induced catecholamine release from cultured bovine adrenal chromaffin cells. (1990) (25)
Molecular oxygen in biology : topics in molecular oxygen research (1974) (25)
Arachidonic acid stimulates phosphoinositide metabolism and catecholamine release from bovine adrenal chromaffin cells. (1990) (25)
Noninvolvement of copper in the L-tryptophan 2,3-digoxygenase reaction. (1973) (25)
Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. (1995) (24)
Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. (1987) (24)
Studies on the interaction between regulatory enzymes and effectors. 3. Crystallization and characterization of adenosine 5'-monophosphate-dependent threonine deaminase from Escherichia coli. (1969) (24)
Tryptophan, oxygen, and sleep. (1994) (24)
A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. (1992) (24)
Studies on a possible reaction intermediate of p-hydroxyphenylpyruvate dioxygenase. (1975) (24)
Inhibitory effects of superoxide dismutases and various other proteins on the nitroblue tetrazolium reduction by phagocytizing guinea pig polymorphonuclear leukocytes. (1975) (24)
Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum. (1983) (24)
Blockade by ONO‐NT‐012, a unique prostanoid analogue, of prostaglandin E2‐induced allodynia in conscious mice (1995) (24)
Synergistic Effect of Prostaglandin E2 and Ouabain on Catecholamine Release from Cultured Bovine Adrenal Chromaffin Cells (1990) (23)
Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. (2003) (23)
Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro (1986) (23)
Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. (1997) (23)
Specific induction of pulmonary indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide. (2008) (23)
NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. (1982) (23)
Adenosine diphosphate-dependent threonine dehydrase activity in extracts of Clostridium tetanomorphum. (1963) (23)
Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. (1989) (23)
Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb (1986) (22)
Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme. (1975) (22)
Intramitochondrial localization of kynurenine aminotransferase. (1970) (22)
Reactions of prostaglandin endoperoxides with prostaglandin I synthetase solubilized from rabbit aorta microsomes. (1979) (22)
Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver. (1971) (22)
Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans (2004) (21)
Energy-linked regulation of threonine metabolism by ADP (1963) (21)
l-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2 (1995) (21)
Immunohistochemical localization of indoleamine 2,3-dioxygenase in the argyrophilic cells of rabbit duodenum and thyroid gland. (1981) (21)
Induction of indoleamine 2,3-dioxygenase in alveolar interstitial cells of mouse lung by bacterial lipopolysaccharide. (1983) (21)
Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells. (1988) (20)
Regulation of biodegradative threonine deaminase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate. (1970) (20)
[27] Purification and properties of tryptophan side chain oxidase types I and II from pseudomonas (1987) (20)
Regulation of biodegradative threonine deaminase. (1976) (20)
Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep. (1993) (20)
Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase. (1972) (20)
Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. (1986) (20)
Oxygenated form of protocatechuate 3,4-dioxygenase, a non-heme iron-containing dioxygenase, as reaction intermediate. (1971) (20)
Reversible enzymatic oxidation of bile acids. (1955) (20)
Stoichiometric utilization of adenosine 5'-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl-1-pyrophosphate. (1966) (19)
N-formimino-L-aspartic acid as an intermediate in the enzymatic conversion of imidazoleacetic acid to formylaspartic acid. (1957) (19)
Genomic organization and characterization of the gene encoding bovine prostaglandin F2α receptor (1997) (19)
lipocalin-type prostaglandin D synthase (2006) (19)
ENZYMATIC FORMATION OF D-KYNURENINE (1963) (19)
Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain (1986) (19)
3 Oxygenases: Dioxygenases (1975) (19)
A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal (1995) (18)
On the activation and catalytic mechanism of microbial tryptophan pyrrolase. (1963) (18)
Characterization of the NAD+ glycohydrolase associated with the rat liver nuclear envelope. (1976) (18)
ENZYMATIC FORMATION OF L-GLUTAMIC ACID AND ACETIC ACID FROM KYNURENIC ACID1 (1959) (18)
Prostaglandin D2 and Sleep (1989) (18)
Involvement of GTP-regulatory protein in brain prostaglandin E2 receptor and separation of the two components. (1986) (18)
Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. (1989) (17)
Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms. (1967) (17)
Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. (1994) (17)
STUDIES ON ENZYMATIC ADAPTATION SUCCESSIVE ADAPTATION, WITH SPECIAL REFERENCE TO THE METABOLISM OF TRYPTOPHAN* (1950) (17)
On the mechanism of activation of L-threonine deaminase from Clostridium tetanomorphum by adenosine diphosphate. (1967) (17)
Enzymatic decarboxylation of malonic acid. (1955) (17)
Effects of Clonidine and Baclofen on Prostaglandin F2α- induced Allodynia in Conscious Mice (1992) (17)
Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase. (1969) (17)
Heterogeneous localization of two cytochrome P-450-dependent monooxygenase activities in dispersed cells of mouse lung. (1982) (16)
Expression of bovine lung prostaglandin F synthase in Escherichia coli. (1991) (16)
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice. (1995) (16)
An odyssey with oxygen. (2005) (16)
Enzymic studies on the mechanism of double hydroxylation. (1966) (16)
Studies on pyrocatechase. 3. Circular dichroism and optical rotatory dispersion. (1969) (16)
2,5-Dihydro-L-phenylalanine: a competitive inhibitor of indoleamine 2,3-dioxygenase. (1978) (16)
Seminar on Poly(ADP-Ribose) and ADP-ribosylation of ProtinePurification and Analysis of the PolyADPribose Synthetase System (1975) (15)
[61] Anthranilic acid conversion to catechol (pseudomonas) (1970) (15)
Regulation of biodegradative threonine deaminase. I. Allosteric inhibition of the enzyme by a reaction product and its reversal by adenosin 5'-monophosphate. (1973) (15)
Indoleamine Dioxygenase - a Possible Biological Function (1984) (15)
Enzymes involved in the formation and further transformations of prostaglandin endoperoxides. (1980) (15)
Effects of indoleamines and their newly identified metabolites on prolactin release in rats. (1978) (15)
PARTICIPATION OF ATP AND COENZYME A IN THE ENZYMATIC DECARBOXYLATION OF MALONIC ACID1 (1953) (15)
Indoleamine 2,3-dioxygenase--with special reference to the mechanism of interferon action. (1985) (15)
Studies on the interaction between regulatory enzymes and effectors. I. Effect of adenosine 5'-monophosphate analogues on threonine deaminase. (1967) (15)
THE BACTERIAL OXIDATION OF TRYPTOPHAN II (1951) (15)
Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission. (2004) (15)
Effects of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated dog basilar arteries. (1974) (15)
Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. (1988) (14)
Enzymatic decarboxylation of oxalic acid. (1956) (14)
Enzymatic conversion of formylaspartic acid to aspartic acid. (1957) (14)
Enzymic hydroxylation. (1969) (14)
Indoleamine 2,3-dioxygenase. Note II. Biological function. (1975) (14)
Adenylate cyclase from Brevibacterium liquefaciens. Reversibility and thermodynamic studies. (1974) (13)
Studies on oxygenases; enzymatic oxidation of imidazoleacetic acid. (1957) (13)
Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. (1995) (13)
Determination of 9α,11β-prostaglandin F2 by stereospecific antibody in various rat tissues (1987) (13)
β-Alanine-α-alanine transaminase of Pseudomonas (1959) (13)
Crucial role of prostaglandin D2 and adenosine in sleep regulation: experimental evidence from pharmacological approaches to gene-knockout mice (2010) (13)
Secretion of lipocalin-type prostaglandin D synthase (beta-trace) from human heart to plasma during coronary circulation. (1999) (13)
Effect of topical prostaglandin D2 on the aqueous humor dynamics in rabbits (2005) (13)
STUDIES ON THE ROLE OF HEMATIN IN THE CATALYTIC MECHANISM OF TRYPTOPHAN PYRROLASE. (1965) (13)
Antagonism of 5-hydroxykynurenamine against serotonin action on platelet aggregation. (1976) (13)
Structure and synthesis of 3-deoxy-D-glycero-pentos-2-ulose, an unusual sugar produced enzymatically from (ADP-ribosyl)histone H2B (1983) (13)
New intermediates in the catabolism of tryptophan in mammalian liver. (1962) (12)
INCORPORATION OF ATMOSPHERIC OXYGEN INTO THE CELL CONSTITUENTS OF A GROWING CULTURE OF Pseudomonas (1957) (12)
Studies on beta-(pyrazolyl-n)-L-alanine. (1963) (12)
Studies on the metabolism of kynurenic acid. I. The formation of L-glutamic acid, D- and L-alanine, and acetic acid from kynurenic acid by Pseudomonas extracts. (1961) (12)
ELECTRONIC ASPECTS OF CATALYSIS OF THE OXYGENASES * (1969) (12)
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID. (1965) (12)
New spectral species of L-lysine monooxygenase, a flavoprotein. (1971) (12)
A role of sulfhydryl groups in imidazoleacetate monooxygenase. (1968) (12)
Enzymatic oxidation of acetyltryptophanamide- and tryptophan-containing peptides. Formation of dehydrotryptophan. (1977) (12)
Superoxide anion as a cofactor of dopamine-β-hydroxylase (1978) (12)
Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. (1993) (12)
L-Lysine oxidase, a new oxygenase. (1961) (12)
Purification of PGH-PGD isomerase from rat brain. (1982) (12)
Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine. (1979) (12)
[14] Special techniques for bacterial enzymes. Enrichment culture and adaptive enzymes (1955) (12)
From Oxygenase to Sleep (2008) (11)
Tryptophan side chain oxidase from Pseudomonas. pH-dependent formation of alpha,beta-didehydro, beta-hydroxy, and beta-keto derivatives of N-acetyltryptophanamide. (1978) (11)
Sleep-wake regulation by PGD2 and E2. (1991) (11)
Lipocalin-Type Prostaglandin D Synthase as an Enzymic Lipocalin (2013) (11)
Studies on the biosynthesis of NAD by a direct method of tracing metabolism in vivo. (1967) (11)
Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9α, 11β-prostaglandin F2 from prostaglandin D2 (1987) (11)
[53] Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rabbit intestine)☆ (1970) (11)
ENZYMIC PREPARATION OF NICOTINATE ADENINE DINUCLEOTIDE (DEAMIDO-NAD). (1964) (11)
lambda-Hydroxytryptophan, not an intermediate between tryptophan and kynurenine. (1950) (10)
Studies on monooxygenases. 3. Examinations of metal participation in flavoprotein monooxygenases of pseudomonads. (1969) (10)
Copper is not essential for the catalytic activity of L-tryptophan 2,3-dioxygenase. (1980) (10)
Purification and properties of tryptophan side chain oxidase types I and II from Pseudomonas. (1987) (10)
Enzymatic modification of tryptophan residues by tryptophan side chain oxidase I and II from Pseudomonas. (1981) (10)
[110] Phospholipases: Phospholipase A Lecithin + H2O → Lysolecithin + Unsaturated fatty acid (1955) (10)
Signal transduction coupled to prostaglandin D2. (1991) (10)
Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. (1996) (10)
Enzymic formation of deoxyadenosine 3',5'-phosphate. (1966) (10)
[25] Poly(ADP-ribose) synthetase from calf thymus (1980) (10)
Role of Iron in Dioxygenase Reactions (1968) (10)
Poly(ADP-ribosyl)ation of Nuclear Proteins (1983) (10)
Crystallization of imidazoleacetate monooxygenase and its characterization as flavoprotein (1966) (10)
Sodium Fluoride Mimics the Effect of Prostaglandin E2 on Catecholamine Release from Bovine Adrenal Chromaffin Cells (1991) (10)
Enzymic formation of acetyl-CoA and CO2 from glutaryl-CoA (1960) (9)
A possible involvement of sulfhydryl groups in the conversion of lysine monooxygenase to an oxidase. (1975) (9)
Prostaglandin E2 Administered Intravenously Crosses the Blood‐Brain Barrier and Induces Hyperthermia as a Central Action (1989) (9)
Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain (1992) (9)
Multivalent Induction of Biodegradative Threonine Deaminase (1977) (9)
Studies on metapyrocatechase. IV. Circular dichroism and optical rotatory dispersion. (1971) (9)
Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs (1990) (9)
THE ACTIVATION OF NUCLEOSIDE DIPHOSPHATASE BY NUCLEOSIDE TRIPHOSPHATES AND ITS POSSIBLE METABOLIC SIGNIFICANCE. (1965) (9)
Inhibition of prostaglandin endoperoxide synthetase by thiol analogues of prostaglandin. (1977) (9)
Subunit structure of biodegradative threonine deaminase. (1977) (9)
Inhibition of brain tryptophan 5-monooxygenase by aquayamycin. (1970) (9)
Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase. (1971) (8)
Solubilization and partial purification of prostaglandin endoperoxide synthetase of rabbit kidney medulla. (1978) (8)
Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. (1985) (8)
Reversible conversion of lysine monooxygenase to an oxidase by modification of sulfhydryl groups. (1973) (8)
Isolation and characterization of the common intermediate in dichotomous reaction catalyzed by tryptophan side chain oxidase. (1983) (8)
Prostaglandin D Synthase, β-Trace and Sleep (1997) (8)
REGULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE BIOSYNTHESIS BY ADENOSINE TRIPHOSPHATE. (1964) (8)
Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat (1995) (8)
Prostaglandin synthesizing enzyme activities of hepatocytes and non-hepatocytes in rat liver as a function of age. (1986) (8)
Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine (1994) (8)
The Relationship between Plasma Kynurenine and Indoleamine 2,3-Dioxygenase Activity in the Extrahepatic Tissues (1984) (8)
NAD glycohydrolases from rat liver nuclei. (1980) (8)
[Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases]. (2004) (7)
Prostaglandin D2: a neuromodulator. (1983) (7)
Circular dichroism of biodegradative threnonine deaminase. (1967) (7)
Reactivating effect of some naturally occurring dithiol compounds on threonine deaminase. (1967) (7)
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase (1999) (7)
Threonine metabolism and its regulation in Clostridium tetanomorphum. (1972) (7)
A new method for oligo (ADP-ribose) fractionation according to chain length. (1981) (7)
Chapter 20 – Immunohistochemistry of Poly(ADP-ribose) (1982) (7)
[6] Overview: Superoxygenase (1984) (7)
Syntheses of [11C]methyl esters of prostaglandins D2 and E2. (1987) (7)
ADP-Ribosylation of Proteins (1985) (7)
Prostaglandins and sleep (2000) (7)
Alteration in morphology and induction of glutamine synthetase in rat glioma C6BU-1 cells cultured with prostaglandin D2-supplemented media (1988) (6)
Studies on the reaction specificity of the flavoprotein lysine monooxygenase with modified substrates. (1976) (6)
THE BACTERIAL OXIDATION OF TRYPTOPHAN IV (1952) (6)
Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor. (1997) (6)
Studies on monooxygenases. IV. Anaerobic formation of an -keto acid by L-lysine monooxygenase. (1972) (6)
Prostaglandin F synthetase, a dual function enzyme. (1988) (6)
Humoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D2 and related substances (2011) (6)
Enzymic oxidation of reduced α-nicotinamide adenine dinucleotide (1967) (6)
Studies on Enzymatic Adaptation (1949) (6)
STUDIES ON THE MECHANISM OF ACTION OF PYROCATECHASE BY ELECTRON SPIN RESONANCE SPECTROSCOPY. (1965) (6)
Indoleamine 2,3-dioxygenase. Note I. Catalytic and molecular properties. (1975) (6)
Binding of pyridoxal phosphate to apoenzymes as studied by optical rotatory dispersion and circular dichroism. (1970) (6)
Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol. (1978) (6)
Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. (1987) (6)
[22] Adenylate cyclase from Brevibacterium liquefaciens (1974) (5)
Properties of poly(ADP-ribose) synthetase and ADP-ribosyl histone splitting enzyme. (1983) (5)
Alkylamine-dependent amino-acid oxidation by lysine monooxygenase--fragmented substrate of oxygenase. (1972) (5)
Problems in production of prostaglandin D2-specific antibody. (1988) (5)
The stabilizing effect of ADP and the binding of ADP by the threonine dehydrase of Clostridium tetanomorphum. (1964) (5)
The Role of Heme in the Tryptophan Pyrrolase Reaction (1968) (5)
Über Den Mechanismus Der Brenzcatechin-Oxydase (Pyrocatechase)-Reaktion (1957) (5)
Chapter 33 – Leukemia and Cancer (1982) (5)
“Fifty Years of Oxygen Activation” (2004) (5)
Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover (1989) (5)
Purification, characterization, and immunohistochemistry of rat brain prostaglandin D synthetase. (1985) (5)
Surface Tension of Aqueous Solutions of Prostaglandins and Related Unsaturated Fatty Acids (1986) (4)
Tryptophan, oxygenase, and sleep. (1996) (4)
Prostaglandin D 2 , a cerebral sleep-inducing substance in monkeys ( slow-wave sleep / rapid-eye-movement sleep / intracerebroventricular infusion / prostaglandin E 2 / Macaca mulatto ) (4)
Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase. (1979) (4)
Indoleamine 2,3‐Dioxygenase: Properties and Functions of a Superoxide Utilizing Enzyme (2007) (4)
ENZYMOLOGICAL STUDIES ON PROSTAGLANDIN BIOSYNTHESIS (1977) (4)
Lactose dehydrogenase, a new flavoprotein. (1960) (4)
5′-ADP-3″Deoxypentos-2″-Ulose. A Novel Product of ADP-Ribosyl Protein Lyase (1985) (4)
Enhancement of catecholamine release may be mediated by prostaglandin E receptor-stimulated phosphoinositide metabolism. (1989) (4)
Memoirs of a biochemist (2006) (4)
[16] Lactose dehydrogenase (1966) (4)
Immobilized Poly(ADP-Ribose) Synthetase: Preparation and Properties (1985) (4)
Lipocalin-type prostaglandin D synthase (beta-trace) binds non-substrate lipophilic ligands. (1999) (4)
Sleep in transgenic and gene-knockout mice for lipocalin-type prostaglandin D synthase (2002) (4)
[116] Mammalian pyridine ribonucleoside phosphokinase (1971) (4)
Key roles of the histaminergic system in sleep-wake regulation (2011) (4)
[120] Picolinic car☐ylase in reference to NAD biosynthesis (1971) (4)
A dehydrogenase reaction catalyzed by lysine monooxygenase, a flavooxygenase. (1976) (4)
Distinct localization of prostaglandin D2, E2 and F2 alpha binding sites in monkey brain. (1989) (4)
Prostaglandin D2: a cerebral sleep-regulating substance in rats. (1985) (4)
16 – Enzymes of Oxygenation (1978) (4)
Biochemical and Biophysical Research Communications: Preface (2005) (4)
Studies on kynurenate hydroxylase: requirement for iron and flavin nucleotide (1966) (4)
Prostaglandin D 2 , a cerebral sleep-inducing substance in rats ( slow wave sleep / paradoxical sleep / intraventricular infusion ) (4)
Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. (1992) (3)
Molecular Mechanisms of Sleep-Wake Regulation: A Role of Prostaglandin D2 and Adenosine (2004) (3)
Antithrombotic Action of Prostaglandins: Different Roles of Prostacyclin and PGD2 (1982) (3)
Reversible inactivation of phosphofructokinase from Brevibacterium liquefaciens. (1971) (3)
Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. (1987) (3)
Regulation of biodegradative threonine deaminase. II. Reaction mechanism as analyzed by spectrophotometric properties. (1973) (3)
Localization of prostaglandin bindings in the central nervous system. (1985) (3)
Expression and cellular localization of -trace in genital organs (1996) (3)
Solubilization, separation, and reconstitution of brain prostaglandin E2 receptor and GTP-regulatory component. (1987) (3)
[94c] β-Alanine-α-alanine transaminase (Pseudomonas): β-Alanine + pyruvic acid ⇄ Malonic semialdehyde + α-alanine (1962) (3)
Evidence for poly(ADP-ribosyl) derivatives of carboxylates in histone. (1984) (3)
Enzymatic formation of prostaglandin F2α in human brain (1990) (3)
Neurochemistry of Sleep and Wakefulness: Prostaglandins and the regulation of sleep and wakefulness (2008) (3)
Alkylamine-dependent oxidation and oxygenation of α-monoamino acids by lysine monooxygenase (1975) (3)
EVIDENCE OF PROSTAGLANDIN PRODUCTION BY THE HUMAN MALARIA PARASITE, PLASMODIUM FALCIPARUM (1998) (3)
[Sleep-promoting substances]. (1998) (3)
Enzymatic formation of prostaglandin D2, E2, and F2α in the parasitic protozoan Trypanosoma brucei (2002) (3)
Poly(ADP-ribose) synthetase from calf thymus. (1980) (3)
Isolation of NADP+-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain. (1982) (3)
3-HYDROXY BILE ACID DEHYDROGENASE FROM ESCHERICHIA FREUNDII (1960) (3)
Effect of prostaglandin E 1 on the induction of rat liver tyrosine aminotransferase. (1972) (3)
β-Hydroxybutyryl-CoA, an intermediate in glutarate catabolism☆ (1961) (3)
Biochemical and Immunological Characterization of Rat Spleen (2001) (3)
Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. (1987) (3)
[52] Poly(ADP-ribose) synthetase (1984) (3)
The structure and function of prostaglandin F synthase. (1991) (3)
Adenylate cyclase from Brevibacterium liquefaciens. (1974) (3)
Adenylate cyclase from Brevibacterium liquefaciens. III. In situ regulation of adenylate cyclase by pyruvate. (1974) (2)
Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver. (1989) (2)
A new assay procedure for indoleamine 2,3-dioxygenase. (1976) (2)
Overview: superoxygenase. (1984) (2)
[130] Adenosine diphosphoribosyltransferase in chromatin (1971) (2)
Chapter VI Separation and Purification of Proteins (1971) (2)
Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. (1987) (2)
Enzymatic formation of prostaglandin F2 alpha in human brain. (1990) (2)
Chapter 16 – ADP-Ribosyl Histone Hydrolase (1982) (2)
Indoleamine 2, 3-dioxygenase: Properties and functions of a superoxide utilizing enzyme (1989) (2)
Musajo Memorial Award Lecture: "Metabolism to function--an odyssey with tryptophan". (2003) (2)
Reaction Mechanism of FAD-Containing Monooxygenases (1968) (2)
ENZYMATIC DEGRADATION OF @KETOADIPIC ACID* (2002) (2)
Studies on the Metabolism of Kynurenic Acid (2001) (2)
A particle concentration fluorescence immunoassay for prostaglandin D synthase in the rat central nervous system. (1990) (2)
Chapter 1 Odyssey of a Biochemist (2007) (2)
Prostaglandin D2 and sleep. (1989) (2)
[75] Pyrimidine oxidase and related enzymes (1955) (2)
Crystal structure of lipocalin-type prostaglandin D synthase (2002) (2)
Developmental changes in the activities of prostaglandin synthesizing enzymes in the digestive and immune systems of rat. (1985) (2)
Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. (1983) (2)
[Rhythms and physiological significance of indoleamine 2,3-dioxygenase (author's transl)]. (1982) (2)
The Role and New Action Mechanism of Prostaglandin E2 in Neurotransmission (1989) (2)
Diphtheria Toxin-catalyzed Adenosine Diphosphoribosylation of Aminoacyl Transferase II from Rat Liver (1972) (2)
Inhibition of DNA ligase activity by histones and its reversal by poly(ADP-ribose). (1983) (2)
Prostaglandin D synthase in human arachnoid, arachnoid villi and meningiomas (1996) (2)
Cloning, nucleotide sequence and gene expression of bovine lung prostaglandin F synthetase. (1989) (2)
Musajo memorial award lecture (2003) (2)
[Prostaglandins and sleep]. (1998) (1)
The brain and prostaglandins. (1984) (1)
Regulation of biodegradative threonine deaminase. 3. Effects of beta substituents of substrate on absorption spectrum and circular dichroism of the enzyme-bound pyridoxal phosphate. (1974) (1)
Molecular basis of sleep-wake regulation — Roles of prostaglandins D2 and E2 (1992) (1)
IV: Dioxygenases and monooxygenases (1984) (1)
Unraveling the enigma of sleep—molecular mechanisms of sleep–wake regulation (2002) (1)
Mystery of sleep. Molecular mechanism of control of sleep. (1997) (1)
Functional‐Site Study of Prostaglandins in the Monkey Brain Using Quantitative Autoradiography and Positron Emission Tomography (1989) (1)
Synergetic action of prostaglandin E2 and ouabain on catecholamine release from cultured bovine adrenal chromaffin cells (1987) (1)
ENZYMATIC ACTIVATION OF MOLECULAR OXYGEN (1980) (1)
Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. (1987) (1)
Shosaku Numa 1927–1992 (1992) (1)
Prostaglandin D2: An Endogenous Somnogen (2011) (1)
Molecular mechanism of prostaglandin D2-mediated non-REM sleep homeostasis studied by gene-knockout mice (2004) (1)
Inhibition of rat brain prostaglandin D synthase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. (1990) (1)
MODULATORY ACTIONS OF PROSTAGLANDINS ON CENTRAL SYNAPTIC TRANSMISSION (1984) (1)
On the prosthetic groups of L-tryptophan 2,3-dioxygenase from Pseudomonas: evidence for noninvolvement of copper in the reaction. (1976) (1)
beta-Alanine-alpha-alanine transaminase of Pseudomonas. (1959) (1)
Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 (2004) (1)
Synthesis of [ribose (NMN)-14C]nicotinamide adenine dinucleotide from D-[14C]glucose. (1981) (1)
Prostaglandin D synthase, beta-trace and sleep. (1997) (1)
Role of Indoleamine 2,3-Dioxygenase in the Defence Mechanism against Tumor Growth (1984) (1)
Fatty acid cyclooxygenase induction and prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. (1999) (1)
Rat monoclonal antibody specific for prostaglandin E structure. (1985) (1)
Phorbol ester inhibits PGE2-induced phosphoinositide metabolism in bovine adrenal chromaffin cells (1988) (1)
Structural basis of multi-functional lipocalin-type prostaglandin D 2 synthase (2005) (1)
Enzymic degradation of beta-(pyrazolyl-N)-L-alanine. (1961) (1)
Arachidonic Acid is Involved in Catecholamine Release Mechanism of PGE2 in Bovine Adrenal Chromaffin Cells (1993) (1)
Distribution of prostaglandin D synthetase in cerebral neocortical neurons: An immunohistochemical study in neonatal rats (1985) (1)
Biological oxidations. (1962) (1)
Introductory remarks — Prostaglandin D synthase, β-trace and sleep (1996) (1)
Proceedings: Purification and analysis of the polyADP-ribose synthetase system. (1975) (1)
Elevated CSF histamine levels in multiple sclerosis patients (2013) (1)
[Cancer and DNA metabolism]. (1962) (0)
[Regulation of threonine metabolism by adenine nucleotides]. (1970) (0)
[Biosynthesis of NAD(DPN) in the brain and its metabolic turnover]. (1966) (0)
Production and secretion of prostanoids by malaria parasite Plasmodium falciparum (1998) (0)
A Tribute to Kunio Yagi (2003) (0)
beta-Hydroxybutyryl-CoA, an intermediate in glutarate catabolism. (1961) (0)
Enzymic Synthesis and Degradation of Prostaglandin D2 (1987) (0)
Structure and Function of Two Distinct Types of Prostaglandin D Synthase (2001) (0)
Indoleamine 2,3-Dioxygenase: Properties and Functions of a Superoxide Utilizing Enzyme (2010) (0)
Effect of trace metals and nucleotide-related compounds on prostaglandin D synthetase activity in rat brain (1990) (0)
Poly ( ADP-ribose ) synthesis , a marker of granulocyte differentiation ( NAD + / chromatin / immunofluorescence / leukocyte / leukemia ) (0)
Sleep inducing effects of PGD2 (1987) (0)
Humoral control of sleep and its evolution (1983) (0)
Symposia Abstracts (2005) (0)
Role of prostaglandin D2 in the regulation of sleep (1996) (0)
2K1600 Characterization of Unfolding Process of Lipocalin-type Prostaglandin D Synthase (2002) (0)
POLY (ADP-RIBOSE) AND ADP-RIBOSYLATION OF PROTEINS1 (1979) (0)
Uptake of 11C-labeled prostaglandin D2 into monkey brain by positron emission tomography study (1987) (0)
[Enzymes of microorganisms-with special reference to adenylate cyclase]. (1974) (0)
TRYPTOPHAN,OXYGE N, AND SLEEP (1994) (0)
Molecular specificity of prostaglandins of their sleep-inducing effects (1988) (0)
Using tetrahydrobiopterinen for preparing a medicament for the treatment of children, autism. (1986) (0)
Prostaglanins activate sleep-related neurons in the preoptic area of rats (1991) (0)
2001 Expression of mRNA for prostaglandin D synthase in leptomeninges and choroid plexus of rat central nervous system, and secretion of the enzyme into the cerebrospinal fluid (1993) (0)
Prostaglandin D2 modulates activity of sleep-related neurons in the preoptic area and neighbouring basal forebrain of the rat (1994) (0)
The effect of prostaglandin on cellular calcium concentration in neuronal cells in culture (1988) (0)
Cancer research: u. S.-Japan cooperative science program. (1966) (0)
Biological Rhythms and Their Central Mechanism:Elsevire/North-Holland Biomedical Press 1979, pp. 453 (1979) (0)
2002 Site of action for the sleep-promoting effect of prostaglandin D2 is located in the rostromedial basal forebrain in the rat (1993) (0)
Characteristics of slow wave EEG accompanying electroconvulsive shock treatment in typical and atypical schizophrenia. (1968) (0)
3-Deoxy-D-glycero-pentos-2-ulose, a novel pentose derived from poly(ADP-ribosyl) histones. (1985) (0)
2025 Clonidine inhibits sleep-active neurons in the preoptic area in the rat (1993) (0)
2003 Neurochemical regulatory mechanism of waking by prostaglandin E2 in the posterior hypothalamus of the rhesus monkey (1993) (0)
Poly(ADP-ribose) synthetase from rat liver nuclei. (1980) (0)
A role of prostaglandin E2 in physiological sleep-wakefulness regulation (1990) (0)
Superoxide anion as a cofactor of dopamine-beta-hydrxylase. (1978) (0)
[Regulatory mechanism of sleep and arousal by PGD2 and PGE2]. (1992) (0)
Rat brain prostaglandin D2 synthase is regulated by thyroid hormone in vivo (1996) (0)
The somnogen PGD2 induces FOS expression within unique populations of sleep-active neurons (1998) (0)
[Bacterial enzymology: adenylate cyclase]. (1974) (0)
[Prostaglandins--current progress in research]. (1982) (0)
Purification and immunohistochemistry of prostaglandin H-E isomoraso in human brain (1987) (0)
Telencephalon specific antigen — An immunohistochemical analysis using a monoclonal antibody (1987) (0)
AN ADP DEPENDENT THREONINE DEHYDRASE FROM CLOSTRIDIUM TETANOMORPHUM (1963) (0)
Tryptophan Pyrrolase of Rabbit Intestine (2003) (0)
L0031 Lipocalin-type prostaglandin D synthase is the key enzyme for production of prostaglandin D2 involved in physiological sleep (2007) (0)
Recent Progress in Sleep Research — Biological, Clinical and Social Impact (2004) (0)
Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E2 and D2 (2004) (0)
L0032 Adenosine A2A receptor deficiency attenuates somnogenic effect of prostaglandin D2 (2007) (0)
Sleep analysis in mice laking lipocalin-type prostaglandin D synthase (1998) (0)
9-Deoxy-A 9 , A 12-13 , 14-dihydroprostaglandin D 2 , a metabolite of prostaglandin D 2 formed in human plasma ( dehydration product of prostaglandin D 2 / serum albumin / cell growth inhibition ) (0)
1004 Sleep-promoting effect of interleukin- 1 β in the rostral basal forebrain (1996) (0)
Automodification of Poly(ADP-ribose) Synthetase and DNA Repair (1981) (0)
Medical research and its impact on future society. (1985) (0)
Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. (1985) (0)
Lack of rebound of non-rapid eye movement sleep after sleep deprivation in adenosine A2A receptor knockout mice (2004) (0)
Obituary for Fellow Member Professor Hideo Nishimura (1912–1995) (1996) (0)
[Metabolism and action of prostaglandin D2 in blood platelets]. (1982) (0)
Studies on Monooxygenases (2002) (0)
Regulation of Biodegradative Threonine in Escherichia coli by Cyclic Adenosine 3', %Monophosphate* Deaminase Synthesis (1970) (0)
ENZYMES AND MEDICINE. (1965) (0)
12 – Indoleamine 2,3-Dioxygenase: A Superoxide-Utilizing Enzyme (1978) (0)
Prostaglandin E2 activates the histaminergic system in the rat brain (2002) (0)
Studies on the sleep-promoting mechanisms mediated by adenosine A2A receptors (1998) (0)
Enzymic formation of acetyl-CoA and carbon dioxide from glutaryl-CoA. (1960) (0)
[Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase]. (1970) (0)
905 Role of Cox-2 enzyme in the interleukin-1-induced slow-wave sleep (1997) (0)
prostaglandin D sleep-wake regulation, with special emphasis on the Invited Review: Molecular genetic studies on (2015) (0)
L0033 Antagonism of prostaglandin D2 receptor inhibits physiological sleep in rats (2007) (0)
[Prostaglandins--present and future]. (1994) (0)
The midsagittal radial glial system in postnatally developing and adult brainstem studied with monoclonal antibody R2D5 (1991) (0)
Immunohistochemical studies of prostaglandin D synthetase in the brain of fetal and newborn rats (1986) (0)
[FROM CLINICAL ENZYME CHEMISTRY TO ISOZYMES]. (1964) (0)
Distribution of prostaglandin D synthetase-containing neurons in the brain of adult rats (1986) (0)
Chemical anatomy of living animal and molecular analysis of higher brain functions by positron emission tomography (1989) (0)
Altered behavioral characteristics of sleep-wake cycle and histaminergic systems in histamine H1 receptor knockout mice (2005) (0)
Metabolism and function of prostaglandin d 2 in brain (1981) (0)
[24] Poly(ADP-ribose) synthetase from rat liver nuclei (1980) (0)
The Pineal Gland: Pineal Chemistry . In Cellular and Physiological Mechanisms. W. B. Quay. Thomas, Springfield, Ill., 1974. xvi, 430 pp., illus. $24.75. American Lecture Series, No. 894. (1974) (0)
Telencephalon-specific antigen: Biochemical characterization and postnatal development (1988) (0)
Enhancement of lipocalin-type prostaglandin D synthase activity by denaturant (2000) (0)
IUB(MB) 50th Anniversary (2005) (0)
The role of extracellular adenosine in the basal ganglia for sleep-wake regulation (2010) (0)
Prostaglandin endoperoxide synthase exists in neurons and glial cells in monkey brain (1990) (0)
Adeno-associated viral (AAV) vectors carrying shRNA for the focal deletion of sleep-active adenosine A2A receptors (2009) (0)
Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. (1987) (0)
[Role of fats in oxidation in living organisms, with special reference to coenzyme O]. (1961) (0)
Sleep suppressive and awaking effects of prostaglandin E2 (PGE2) in the rhesus monkey. (1991) (0)
Molecular aspect of PGD2 on inducing sleep (1988) (0)
[Advances in enzymology in urology]. (1966) (0)
Prostaglandins: fundamental and clinical aspects. (1987) (0)
Purification and Properties of Nucleoside Hydrolase from Pseudomonas jhorescens* (2003) (0)
A Possible Specific Urine Biomarker For Severe Obstructive Sleep Apnea And Cardiovascular Diseases-Lipocalin-Type Prostaglandin D Synthase (L-PGDS) (2012) (0)
Osamu Hayaishi From Oxygenase to Sleep (2008) (0)
[The brain and prostaglandins]. (1983) (0)
(lung slices/influenza virus/endotoxin) (2016) (0)
Letter from Osamu Hayaishi to Joshua Lederberg (1962) (0)
The possible involvement of prostaglandin(PG)D2 in the differentiation of neuroblastoma (1985) (0)
Fatty acid cyclooxygenase induction accompanied by prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester. (2000) (0)
fl/2'-(5"-phosphoribosyll-5'-AMP) (1975) (0)
Possible pathogenesis of acquired immune deficiency syndrome in homosexual males: an unexpected action of seminal prostaglandin E2 on AIDS-virus infection. (1987) (0)
Prostaglandin D synthetase exists in both neurons and oligodendrocytes: An immunohistochemical study in adult rats (1985) (0)
METABOLIC FUNCTION OF EDOXYNUCLEOSIDIC COMPOUNDS. (1962) (0)
Studies on the Interaction between Regulatory Enzymes and Effecters (2003) (0)
Alkylamine-dependent oxidation and oxygenation of alpha-monoamino acids by lysine monooxygenase. (1975) (0)
Regulation of Ca2+/calmodulin-dependent protein phosphorylation by prostaglandin D2 in mitochondrial fractions of rat brain (1986) (0)
Recent progress in sleep research: Medical and social impact (2004) (0)
A study on the mechanisms of hypoalgesia by intracisternal administration of prostaglandins (pgs) in conscious mice (1987) (0)
Channel Contribution to Excitability Biophysical Characterization of Rat Caudal Hypothalamic Neurons: Calcium (2008) (0)
[Scientific study of sleep--molecular mechanism for the regulation of sleep and wakefulness]. (1998) (0)
Sex hormones for treatment of immune-deficient diseases. (1986) (0)
Sleep-suppressive effect of prostaglandin E2 can be dissociated from its pyrogenic effect in rhesus monkey (1990) (0)
anthranilic acid is oxidized through pyrocatechin and the disrupture (2021) (0)
Responses of preoptic sleep-related neurons to stimulation of the locus ceruleus and the ventrolateral medulla in the rat (1992) (0)
501 Prostaglandin D synthase (β-trace) in human meninges (1997) (0)
Prostaglandin F synthetase--a dual function enzyme. (1989) (0)
Immunohistochemical Localization of Indoleamine 2,3-dioxygenase in the Argyrophil Cells of the Gut and the Thyroid Gland (1979) (0)
The effects of prostaglandins on the differentiation of NG108-15 hybrid cells (1986) (0)
Increase in striatal dopamine D1 and D2 receptor binding by ketamine: Positron emission tomography study using the conscious rhesus monkey (1991) (0)

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