Peter A. Edwards
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(Suggest an Edit or Addition)Peter A. Edwards's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. (1995) (1852)
- A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis (2001) (1176)
- Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. (2000) (986)
- Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor* (2002) (914)
- Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. (2006) (846)
- ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. (2005) (817)
- Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. (1980) (799)
- The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. (1996) (750)
- Pleiotropic roles of bile acids in metabolism. (2013) (743)
- Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. (2013) (740)
- A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. (2001) (617)
- LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response (2008) (610)
- Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. (1999) (451)
- Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages (2000) (405)
- BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. (2002) (371)
- A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. (2003) (351)
- Regulation of gene expression by SREBP and SCAP. (2000) (323)
- Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR (2004) (312)
- Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. (2001) (312)
- FXR, a multipurpose nuclear receptor. (2006) (308)
- A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. (2005) (286)
- Characterization of the Human ABCG1 Gene (2001) (275)
- Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor* (2000) (273)
- Natural Structural Variants of the Nuclear Receptor Farnesoid X Receptor Affect Transcriptional Activation* (2003) (273)
- Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins. (1982) (256)
- Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages (2002) (251)
- Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene* (1997) (245)
- LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. (2013) (245)
- Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. (1990) (234)
- Role of ABC transporters in lipid transport and human disease (2013) (234)
- Identification of Conserved cis-Elements and Transcription Factors Required for Sterol-regulated Transcription of Stearoyl-CoA Desaturase 1 and 2* (1999) (231)
- LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. (2002) (226)
- Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages. (1981) (202)
- FXR signaling in metabolic disease (2008) (201)
- Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. (2013) (200)
- The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. (1986) (197)
- ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter (2011) (188)
- Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr−/− and ApoE−/− Mice Transplanted With Abcg1−/− Bone Marrow (2006) (185)
- In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat. (1972) (184)
- Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1994) (178)
- The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages. (1981) (176)
- COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase. (1992) (175)
- Expression and Regulation of Multiple Murine ATP-binding Cassette Transporter G1 mRNAs/Isoforms That Stimulate Cellular Cholesterol Efflux to High Density Lipoprotein* (2004) (169)
- Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. (2004) (166)
- Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. (1996) (166)
- FXR Deficiency Causes Reduced Atherosclerosis in Ldlr−/− Mice (2006) (155)
- MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor (2013) (140)
- FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine Published, JLR Papers in Press, October 26, 2005. (2006) (137)
- ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Published, JLR Papers in Press, October 4, 2007. (2008) (136)
- Hepatic Hepatocyte Nuclear Factor 4&agr; Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis (2011) (127)
- Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.C200014-JLR200 (2002) (121)
- Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages. (1985) (120)
- Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. (2012) (117)
- Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity. (1993) (115)
- Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1* (1998) (113)
- Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene* (1996) (111)
- Farnesyl-diphosphate synthase is localized in peroxisomes. (1994) (111)
- Loss of ABCG1 Results in Chronic Pulmonary Inflammation1 (2008) (111)
- Deletion of the Transmembrane Transporter ABCG1 Results in Progressive Pulmonary Lipidosis* (2006) (111)
- Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity. (1992) (110)
- NF-Y Has a Novel Role in Sterol-dependent Transcription of Two Cholesterogenic Genes (*) (1995) (110)
- Emerging new paradigms for ABCG transporters. (2009) (107)
- Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes. (1983) (106)
- Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia* (2009) (99)
- Syndecan-1 Expression Is Regulated in an Isoform-specific Manner by the Farnesoid-X Receptor* (2003) (99)
- Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway (1987) (97)
- Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1 (2010) (94)
- FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (2006) (94)
- Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide. (1972) (92)
- Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin. (1983) (89)
- LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells. (1984) (89)
- Signaling molecules derived from the cholesterol biosynthetic pathway. (1997) (87)
- Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1979) (87)
- Regulation of the uptake and degradation of beta-very low density lipoprotein in human monocyte macrophages. (1983) (87)
- ATP-binding cassette transporter G1 and lipid homeostasis (2006) (83)
- Separation of and cholesterol synthesis by human lymphocytes and monocytes. (1979) (83)
- Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein. (1998) (81)
- Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5 (1986) (81)
- Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester. (1990) (79)
- Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man. (1979) (77)
- Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity. (1980) (75)
- FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. (2021) (73)
- Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. (1994) (73)
- Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. (2010) (71)
- Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. (1977) (70)
- Macrophage lipoprotein receptors (1988) (68)
- Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein. (1984) (68)
- MAFG is a transcriptional repressor of bile acid synthesis and metabolism. (2015) (68)
- The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis. (1984) (67)
- Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes. (1977) (64)
- Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol. (1983) (63)
- Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance. (1986) (63)
- YY1 Is a Negative Regulator of Transcription of Three Sterol Regulatory Element-binding Protein-responsive Genes* (1999) (63)
- Impaired Development of Atherosclerosis in Abcg1−/− Apoe−/− Mice: Identification of Specific Oxysterols That Both Accumulate in Abcg1−/− Apoe−/− Tissues and Induce Apoptosis (2010) (62)
- Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin. (1988) (62)
- Regulation of hepatic Insig-2 by the farnesoid X receptor. (2007) (60)
- Bacterial endotoxin selectively prevents the expression of scavenger-receptor activity on human monocyte-macrophages. (1985) (60)
- The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes. (1975) (59)
- Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol. (1981) (59)
- CBP Is Required for Sterol-regulated and Sterol Regulatory Element-binding Protein-regulated Transcription* (1998) (59)
- Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. (2012) (58)
- Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells. (1989) (56)
- CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. (2001) (53)
- Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase. (1989) (49)
- Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation. (1982) (49)
- Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S] (2006) (49)
- A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids Published, JLR Papers in Press, November 3, 2005. (2006) (48)
- Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene. (1992) (47)
- Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. (1977) (47)
- The effect of glucagon, norepinephrine, and dibutyryl cyclic AMP on cholesterol efflux and on the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat hepatocytes. (1979) (47)
- Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression. (1992) (46)
- Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver. (1983) (46)
- α-Crystallin Is a Target Gene of the Farnesoid X-activated Receptor in Human Livers* (2005) (46)
- MicroRNA-144 Regulates Hepatic ABCA1 and Plasma HDL Following Activation of the Nuclear Receptor FXR (2013) (44)
- Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. (1985) (44)
- Effect of adrenalectomy and hypophysectomy on the circadian rhythm of -hydroxy- -methylglutaryl coenzyme A reductase activity in rat liver. (1973) (43)
- Differential expression and function of ABCG1 and ABCG4 during development and aging. (2010) (43)
- Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease. (1998) (43)
- Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling Published, JLR Papers in Press, December 16, 2004. DOI 10.1194/jlr.M400292-JLR200 (2005) (42)
- Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase of isolated rat hepatocytes. (1975) (42)
- Differential expression and function of ABCG1 and ABCG4 during development and aging[S] (2010) (40)
- The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1982) (40)
- Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation. (1985) (39)
- Bile acids have the gall to function as hormones. (2009) (38)
- Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells. (1996) (38)
- Dependence of the circadian rhythm of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A on ribonucleic acid synthesis. A possible second site of inhibition by dietary cholesterol. (1974) (38)
- Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA (1990) (37)
- Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1986) (30)
- Lymphokines secreted by an established lymphocyte line modulate receptor-mediated endocytosis in macrophages derived from human monocytes. (1983) (30)
- Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. (1989) (29)
- In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues. (1991) (28)
- Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. (1998) (27)
- A direct relationship between the amount of sterol lost from rat hepatocytes and the increase in activity of HMG-CoA reductase. (1976) (25)
- Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase. (1994) (24)
- A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism (2020) (22)
- Lipoprotein regulation of cholesterol metabolism in macrophages derived from human monocytes. (1982) (20)
- Chapter 13 – Isoprenoids, sterols and bile acids (1996) (19)
- Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. (1989) (19)
- Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism (2021) (19)
- Purification and properties of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1979) (18)
- Analysis of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant auxotrophic for mevalonate. (1982) (17)
- Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. (1991) (17)
- Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550—Brief Report (2016) (17)
- Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL. (1992) (17)
- Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver. (1982) (13)
- High density lipoproteins and lecithin dispersions increase the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by increasing the rate of synthesis and decreasing the rate of degradation of the enzyme. (1984) (12)
- Activation of the Farnesoid X-Activated Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity (2010) (12)
- The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. (2021) (11)
- Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. (2014) (10)
- Regulation of the Sodium/Sulfate Co-transporter by Farnesoid X Receptor α* (2007) (10)
- Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase. (1992) (10)
- The effect of glucagon on the synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1988) (8)
- Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes. (1977) (8)
- Polyisoprenoid synthesis and metabolism. (1992) (8)
- Notes on the breeding of the WHHL rabbit: an animal model of familial hypercholesterolemia. (1985) (6)
- 4 – Studies on Purified Mammalian HMG-CoA Reductase and Regulation of Enzyme Activity (1985) (6)
- Chapter 8 Cellular regulation of cholesterol metabolism (1987) (6)
- Biological effects of isoprenoids (1991) (5)
- Fatty livers and reduced adipose tissue, who wants it? (1996) (5)
- Chapter 13 Regulation of sterol biosynthesis and isoprenylation of proteins (1991) (3)
- Some New Aspects of the Regulation of Cholesterol Biosynthesis and Metabolism of Mevalonate (1976) (3)
- Cellular enzymes of cholesterol metabolism (1990) (3)
- Macrophage lipoprotein metabolism in atherosclerosis (1985) (1)
- Hepatic cholesterol and lipoprotein conference. Report of a conference. (1989) (1)
- CHAPTER 170 – Cholesterol Signaling (2003) (1)
- Platelet Production of Pathological LDL (1980) (1)
- Assignment of Gpam to distal mouse Chromosome 19 by linkage analysis (2009) (1)
- The ABCs of sterol transport 1 (2009) (1)
- Effect of Adrenalectomy and Hypophysectomy on the Circadian Rhythm of P-Hydroxy-P-methylglutaryl Coenzyme A Reductase Activity in Rat Liver* (2002) (1)
- Abstract 21: Loss of Abcg1 Drives the Site-selective Expansion of B-1 B Cells and Secretion of Atheroprotective Natural Antibodies, in Response to Local Accumulation of Specific Oxidized Lipids (2013) (0)
- Abstract 49: The Transcriptional Repressor MafG Regulates Cholesterol Catabolism (2015) (0)
- 1200 nt rat liver mRNA identified by differential hybridization exhibits coordinate regulation with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (1986) (0)
- lsoprenoids Biosynthesis and Role in the Regulation of Protein Function (2009) (0)
- Lymphocyte-conditioned medium p macrophages from cholesteryl este: (atherosclerosis/lipoprotein receptors/lymphokines) (2016) (0)
- Erratum: Characterization of the human ABCG1 gene. Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein (Journal of Biological Chemistry (2001) 276 (39438-39447)) (2002) (0)
- Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway (1987) (0)
- A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism (2020) (0)
- Malondialdehyde alteration of low c cholesteryl ester accumulation in hi (cell surface receptors/blood platelets/atherosclerosis) (2016) (0)
- Developmentally Regulated and Localized to Haploid Germ Cells1 (1991) (0)
- Natural Structural Variants of the Nuclear Receptor FXR Affect Transcriptional Activation (2002) (0)
- P1844The transcription factor MAFF regulates an atherosclerosis relevant gene network (2018) (0)
- In Memoriam: Roger A. Davis (1945–2008) (2008) (0)
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What Schools Are Affiliated With Peter A. Edwards?
Peter A. Edwards is affiliated with the following schools:
