Philip Coffino
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Philip Coffinobiology Degrees
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Molecular Biology
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Biology
Philip Coffino's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Philip Coffino Influential?
(Suggest an Edit or Addition)Philip Coffino's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Ubiquitin and proteasomes: Regulation of cellular polyamines by antizyme (2001) (340)
- Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation. (1989) (220)
- Selection of a variant lymphoma cell deficient in adenylate cyclase. (1975) (220)
- Cloning of mouse myeloma cells and detection of rare variants (1972) (209)
- High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation (1996) (209)
- Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin‐independent substrate (2003) (204)
- Eighth International Workshop on Human Gene Mapping (1984) (195)
- Ubiquitin-independent proteasomal degradation. (2014) (193)
- Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain (2004) (184)
- Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. (1971) (175)
- Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells (1977) (174)
- The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. (2006) (169)
- Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells. (1976) (163)
- Molecular cloning and expression of the mouse ornithine decarboxylase gene. (1984) (160)
- Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition. (1987) (154)
- Faculty Opinions recommendation of Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. (2003) (147)
- Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein (1993) (147)
- Sequestered end products and enzyme regulation: the case of ornithine decarboxylase (1992) (146)
- Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth (1975) (145)
- Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme (1992) (144)
- Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. (1999) (138)
- Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation. (1990) (137)
- Proteasome substrate degradation requires association plus extended peptide (2007) (122)
- Ubiquitin-free routes into the proteasome. (2004) (113)
- Inhibition of protein synthesis stabilizes histone mRNA (1984) (105)
- Cyclic AMP, a nonessential regulator of the cell cycle. (1975) (103)
- Cell cycle analysis by flow cytometry. (1979) (102)
- Somatic genetic analysis of cyclic AMP action: Selection of unresponsive mutants (1975) (102)
- Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation (1992) (90)
- Antizyme, a mediator of ubiquitin-independent proteasomal degradation. (2001) (84)
- G1 and S phase mammalian cells synthesize histones at equivalent rates (1980) (84)
- [19] Cell cycle analysis by flow cytometry (1979) (83)
- Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase (1994) (83)
- Mutations in Immunoglobulin-Producing Moose Myeloma Cells (1973) (80)
- Antizyme2 Is a Negative Regulator of Ornithine Decarboxylase and Polyamine Transport* (1999) (78)
- Reconfiguration of the proteasome during chaperone-mediated assembly (2013) (78)
- Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational (1989) (78)
- Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA. (1985) (76)
- Glycine–alanine repeats impair proper substrate unfolding by the proteasome (2006) (75)
- Ubiquitin-independent Mechanisms of Mouse Ornithine Decarboxylase Degradation Are Conserved between Mammalian and Fungal Cells* 210 (2003) (75)
- Somatic genetic analysis of cyclic AMP action: Characterization of unresponsive mutants (1975) (75)
- Two-dimensional gel analysis of cyclic amp effects in cultured s49 mouse lymphoma cells: Protein modifications, inductions and repressions (1979) (74)
- Mutagenesis in S49 mouse lymphoma cells: induction of resistance to ouabain, 6-thioguanine, and dibutyryl cyclic AMP. (1977) (71)
- Repeat Sequence of Epstein-Barr Virus-encoded Nuclear Antigen 1 Protein Interrupts Proteasome Substrate Processing* (2004) (69)
- Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase (1978) (69)
- An Easily Dissociated 26 S Proteasome Catalyzes an Essential Ubiquitin-mediated Protein Degradation Pathway in Trypanosoma brucei * 210 (2002) (69)
- Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. (1985) (68)
- Beta adrenergic receptors and adenylate cyclase: products of separate genes? (1976) (67)
- Immunoglobulin Production: Method for Quantitatively Detecting Variant Myeloma Cells (1970) (63)
- Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells (1986) (56)
- Mouse ornithine decarboxylase gene: cloning, structure, and expression. (1988) (56)
- Expression and post-transcriptional regulation of ornithine decarboxylase during early Xenopus development. (1991) (55)
- Proteasomes Begin Ornithine Decarboxylase Digestion at the C Terminus* (2004) (55)
- Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase. (2008) (55)
- Suppression of immunoglobulin synthesis by cellular hybridization. (1971) (54)
- Functional Asymmetries of Proteasome Translocase Pore* (2012) (54)
- Tenth International Workshop on Human Gene Mapping (1988) (53)
- A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. (1975) (50)
- alpha5 subunit in Trypanosoma brucei proteasome can self-assemble to form a cylinder of four stacked heptamer rings. (1999) (50)
- Mechanism of lymphoma cell death induced by cyclic AMP. (1975) (50)
- Molecular mechanisms of cyclic AMP action: a genetic approach. (1976) (49)
- Dependence of Proteasome Processing Rate on Substrate Unfolding* (2011) (49)
- Structural Elements of Antizymes 1 and 2 Are Required for Proteasomal Degradation of Ornithine Decarboxylase* (2002) (47)
- Cyclic amp-induced cytolysis in S49 cells: selection of an unresponsive “deathless” mutant (1977) (47)
- Regulation of mouse ornithine decarboxylase activity by cell growth, serum and tetradecanoyl phorbol acetate is governed primarily by sequences within the coding region of the gene. (1989) (44)
- Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli. (1988) (43)
- Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover. (1983) (41)
- Polyamines in spermiogenesis: not now, darling. (2000) (41)
- Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease. (1995) (39)
- Increased histone mRNA levels during inhibition of protein synthesis. (1983) (39)
- A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase. (1983) (37)
- Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. (2003) (33)
- Developmental effect of polyamine depletion in Caenorhabditis elegans. (1998) (33)
- Dominant negative mutants of ornithine decarboxylase. (1992) (33)
- Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. (1979) (32)
- Probing the ubiquitin/proteasome system with ornithine decarboxylase, a ubiquitin-independent substrate. (2005) (32)
- Regulated Degradation of Yeast Ornithine Decarboxylase* (1999) (31)
- The N Terminus of Antizyme Promotes Degradation of Heterologous Proteins (*) (1996) (30)
- Slippery Substrates Impair Function of a Bacterial Protease ATPase by Unbalancing Translocation versus Exit* (2013) (27)
- Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: A genetic and biochemical analysis (1970) (27)
- Degradation of Ornithine Decarboxylase (1998) (25)
- Role of ornithine decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs. (1992) (25)
- Independent mechanisms of cyclic AMP and glucocorticoid action (1977) (24)
- Identification of a Region of p53 That Confers Lability (*) (1996) (23)
- Rat Antizyme Inhibits the Activity but Does Not Promote the Degradation of Mouse Ornithine Decarboxylase in Trypanosoma brucei(*) (1995) (23)
- Nucleotide sequence of the mouse ornithine decarboxylase gene. (1988) (23)
- Complementation analysis of hormone-sensitive adenylate cyclase (1978) (22)
- Genetic analysis of cyclic AMP in a mammalian cell. (1975) (21)
- The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis. (1995) (21)
- THE REGULATION OF IMMUNOGLOBULIN SYNTHESIS AND ASSEMBLY * (1971) (20)
- Regulation of S49 lymphoma cell growth by cyclic adenosine 3':5'-monophosphate. (1978) (20)
- Development of a method for screening short-lived proteins using green fluorescent protein (2004) (19)
- Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient Derived Xenografts and Direct from Patient Screening. (2021) (18)
- Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent (1979) (18)
- Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP (1977) (17)
- A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin‐independent substrate (2008) (17)
- A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2. (1988) (17)
- Mechanism of 2-aminopurine mutagenesis in mouse T-lymphosarcoma cells (1982) (16)
- Centennial of Wilhelm Waldeyer’s introduction of the term “chromosome” (1988) (16)
- Complementation of a polyamine-deficient Escherichia coli mutant by expression of mouse ornithine decarboxylase (1987) (16)
- Killer polyamines? (1991) (16)
- Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells (1983) (15)
- Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase (1983) (14)
- Linkage genetics of mouse ornithine decarboxylase (Odc). (1989) (14)
- [2] Cultured S49 mouse T lymphoma cells (1987) (12)
- Cultured S49 mouse T lymphoma cells. (1987) (11)
- Slippery Substrates Impair ATP-dependent Protease Function by Slowing Unfolding (2014) (11)
- Allosteric coupling between α-rings of the 20S proteasome (2019) (11)
- Reversion of an S49 cell cyclic AMP-dependent protein kinase structural gene mutant occurs primarily by functional elimination of mutant gene expression (1983) (11)
- A homolog of mammalian antizyme is present in fission yeast Schizosaccharomyces pombe but not detected in budding yeast Saccharomyces cerevisiae (2000) (10)
- Revertants of an S49 cell mutant that expresses altered cyclic AMP-dependent protein kinase (1982) (10)
- Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. (1977) (9)
- Probable cloning artefacts previously interpreted as unusual leader sequences of rodent ornithine decarboxylase mRNAs--a cautionary tale. (1988) (9)
- Quantitative forward-mutation specificity of mono-functional alkylating agents, ICR-191, and aflatoxin B1 in mouse lymphoma cells. (1982) (9)
- Receptors for Low-Molecular-Weight Hormones on Lymphocytes (1977) (8)
- Molecular cloning andexpression ofthemouseornithine decarboxylase gene (1984) (6)
- Ornithine decarboxylase of African trypanosomes. (1990) (5)
- Crystallization of a mammalian ornithine decarboxylase (1996) (5)
- Multiple active conformers of mouse ornithine decarboxylase. (1993) (4)
- Varshavsky's Contributions (2004) (4)
- Ubiquitin‐Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome (2007) (3)
- The use of mouse and human cell lines in studying the regulation of immunoglobulin production. (1973) (3)
- Targeting BCL-XL in fibrolamellar hepatocellular carcinoma (2022) (3)
- Hypoxanthine-guanine phosphoribosyl transferase with altered substrate affinity in mutant mouse lymphoma cells. (1977) (3)
- Ubiquitin-proteasome system (2004) (3)
- Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles (2022) (2)
- Hormonal regulation of cloned genes (1981) (2)
- Mutagenesis of S49 mouse lymphoma cells (1978) (2)
- Growth regulation of S49 lymphoma cells: analysis of cAMP responsiveness and polyamine metabolism. (1981) (1)
- GENETIC AND FUNCTIONAL STUDIES OF THE CYCLIC AMP RECEPTOR IN A CULTURED MAMMALIAN CELL (1976) (1)
- Hormone-Mediated Lymphoma Cell Death: Mechanisms Of Glucocorticoid And Cyclic Amp Action (1976) (1)
- 1288 – CYCLIC NUCLEOTIDES AND CONTROL OF CELL PROLIFERATION (1977) (1)
- SUMMARY REMARKS OF CHAIRMAN (1977) (1)
- Ubiquitin Proteasome System in Stress and Disease (2012) (1)
- Erratum (2003) (0)
- Faculty Opinions recommendation of Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease. (2012) (0)
- The Molecular Biology of Mouse Ornithine Decarboxylase (2021) (0)
- Rate of Somatic Mutation in Immunoglob by Mouse Myeloma Cells (2016) (0)
- Growth Regulatory Effects of Depletion Are Dissociable in Cells Cyclic AMP and Cultured Mouse Polyamine Lymphoma (2003) (0)
- Faculty Opinions recommendation of Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. (2002) (0)
- Mutagenesis of s49 mouse lymphoma cells. Abstr. (1978) (0)
- Ornithine Decarboxylase Gene Amplification (1992) (0)
- Abstract 2494: Pathogenesis of fibrolamellar: Proteome and phosphome of an oncokinase driven cancer (2022) (0)
- Abstract 6729: Urea cycle metabolism is disturbed in Fibrolamellar carcinoma (2023) (0)
- Regulation of Lymphoma Cell Growth by Cyclic AMP (1979) (0)
- CRYSTAL STRUCTURE ORNITHINE DECARBOXYLASE FROM MOUSE, TRUNCATED 37 RESIDUES FROM THE C-TERMINUS, TO 1.6 ANGSTROM RESOLUTION (1999) (0)
- Faculty Opinions recommendation of A cotranslational ubiquitination pathway for quality control of misfolded proteins. (2013) (0)
- Faculty Opinions recommendation of Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines. (2005) (0)
- Faculty Opinions recommendation of The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. (2002) (0)
- Cyclic AMP, A Nonessential Regulator of (lymphoma/mutants/flow microfluorimeter) (2016) (0)
- Somatic Genetic Analysis of Hormone Action (1981) (0)
- Molecular cloning and expression of the mouse ornithine decarboxylase gene ( gene amplification / hormonal induction / cDNA ) (0)
- The Ornithine Decarboxylase Gene of Camrhabditis elegam (2002) (0)
- Erratum (2009) (0)
- Joana Exit versus Translocation Bacterial Protease ATPase by Unbalancing Slippery Substrates Impair Function of a Protein Synthesis and Degradation (2013) (0)
- Faculty Opinions recommendation of Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. (2003) (0)
- Mutagenesis in S 49 mouse lymphoma cells : Induction of resistance to ouabain , 6-thioguanine , and dibutyryl cyclic AMP ( protein kinase / nitrosoguanidine / ethyl methanesulfonate / ICR 191 / x-rays ) (0)
- Faculty Opinions recommendation of Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation. (2015) (0)
- Faculty Opinions recommendation of Defining the geometry of the two-component proteasome degron. (2011) (0)
- Studies of cyclic AMP action using mutant tissue culture cells (2007) (0)
- Letter from Herbert W. Boyer, Philip Coffino, and Harold Varmus to Daphne Kamely, National Institute of General Medical Sciences (1977) (0)
- Ordering an engagement ring. (2010) (0)
- Title Sequestered end products and enzyme regulation : The case of ornithine decarboxylase Permalink (0)
- Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase. (1978) (0)
- Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function (2022) (0)
- Abstract 3888: Targeting Bcl-xL in fibrolamellar hepatocellular carcinoma (2022) (0)
- Molecular-Weight Hormones on Lymphocytes (1977) (0)
- Faculty Opinions recommendation of Endoproteolytic activity of the proteasome. (2003) (0)
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What Schools Are Affiliated With Philip Coffino?
Philip Coffino is affiliated with the following schools:
