Philip D. Lawley

Q: What Schools Are Affiliated With Philip D. Lawley

Philip D. Lawley is affiliated with the following schools: University of Western Ontario, Institute of Cancer Research

Philip D. Lawley's AcademicInfluence.com Rankings

Philip D. Lawley

Chemistry

#2729

World Rank

#3678

Historical Rank

chemistry Degrees

Download Badge

Chemistry

Philip D. Lawley's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

Why Is Philip D. Lawley Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Philip D. Lawley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES. (1963) (693)
Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid (1964) (664)
The reaction of mono- and di-functional alkylating agents with nucleic acids. (1961) (540)
Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. (1970) (461)
Some chemical aspects of dose-response relationships in alkylation mutagenesis. (1974) (285)
DNA adducts from chemotherapeutic agents. (1996) (274)
Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action (1965) (259)
Interstrand cross-linking of DNA by difunctional alkylating agents. (1967) (258)
The reaction of mustard gas with nucleic acids in vitro and in vivo. (1960) (219)
Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography. (1978) (177)
Effects of some chemical mutagens and carcinogens on nucleic acids. (1966) (167)
Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels. (1972) (164)
Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA. (1969) (156)
Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic Properties of Alkylating Agents (1961) (146)
Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N'-nitro-N-nitrosoguanidine. (1970) (137)
766. The alkylation of guanosine and guanylic acid (1961) (134)
112. The methylation of adenosine and adenylic acid (1960) (124)
EFFECTS OF ALKYLATING AGENTS ON T2 AND T4 BACTERIOPHAGES. (1963) (123)
REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS. (1964) (115)
Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen. (1968) (111)
Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids. (1968) (109)
Methylation of DNA by N-Methyl-N-nitrosourethane and N-Methyl-N-nitroso-N′-nitroguanidine (1968) (107)
Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines. (1975) (102)
Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine. (1973) (91)
Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3'-5')thymidine. (1978) (86)
Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl)methylamine. (1995) (84)
Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid. (1972) (79)
Ionization of DNA bases or base analogues as a possible explanation of mutagenesis, with special reference to 5-bromodeoxyuridine. (1962) (79)
THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID IN RELATION TO BIOLOGICAL EFFECTS OF THE ALKYLATING AGENTS. (1963) (75)
Reaction of alkylating mutagens and carcinogens with nucleic acids: detection and estimation of a small extent of methylation at O-6 of guanine in DNA by methyl methanesulphonate in vitro. (1972) (74)
Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate. (1976) (70)
Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group. (1973) (66)
Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts (1981) (65)
Mutagens as carcinogens: development of current concepts. (1989) (64)
Reaction of N-methyl-N-nitrosourea (MNUA) with 32P-labelled DNA: evidence for formation of phosphotriesters. (1973) (62)
Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours. (1975) (61)
DNA as a target of alkylating carcinogens. (1980) (61)
254. The methylation of cystosine and cytidine (1962) (60)
The relative reactivities of deoxyribonucleotides and of the bases of DNA towards alkylating agents. (1957) (60)
Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate. (1972) (55)
Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking. (1993) (55)
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects. (1980) (54)
Molecular mechanisms in alkylation mutagenesis. Induced reversion of bacteriophage T4rII AP72 by ethyl methanesulphonate in relation to extent and mode of ethylation of purines in bacteriophage deoxyribonucleic acid. (1975) (49)
The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17. (1974) (45)
Interaction studies with DNA. III. The effect of changes in sodium ion concentration, pH and temperature on the ultra-violet absorption spectrum of sodium thymonucleate. (1956) (45)
DEFECTIVE REPAIR OF 06-METHYLGUANINE IN AUTOIMMUNE DISEASES (1982) (45)
EVIDENCE FOR THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID. (1963) (42)
N-Nitroso compounds. (1983) (40)
Methylation of nucleic acids by 2,2-dichlorovinyl dimethyl phosphate (dichlorvos, DDVP). (1974) (40)
Methylated bases in liver nucleic acids from rats treated with dimethylnitrosamine (1968) (39)
Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response. (1980) (38)
Historical origins of current concepts of carcinogenesis. (1994) (37)
Reaction of hydroxylamine at high concentration with deoxycytidine or with polycytidylic acid: Evidence that substitution of amino groups in cytosine residues by hydroxylamino is a primary reaction, and the possible relevance to hydroxylamine mutagenesis (1967) (35)
Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents. (1975) (34)
Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected. (1972) (34)
Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses. (1987) (33)
Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea. (1976) (33)
Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN-dimethylnitrosamine. (1972) (33)
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea. (1975) (30)
Alkylation of DNA and its aftermath. (1995) (30)
Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine (1976) (30)
Methylation of adenine in deoxyadenylic acid or deoxyribonucleic acid at N-7. (1964) (27)
Increased urinary excretion of pyrimidine and nicotinamide derivatives in rats treated with methyl methane-sulphonate (1974) (27)
Mode of action of methylating carcinogens: comparative studies of murine and human cells. (1981) (27)
Products from alkylation of DNA in cells by melphalan: human soft tissue sarcoma cell line RD and Escherichia coli WP2. (1995) (26)
The action of alkylating agents on deoxyribonucleic acid (1961) (25)
Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine. (1986) (23)
The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage mu2. (1971) (22)
Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea. (1988) (20)
Effects of alkylating agents on the induced synthesis of beta-galactosidase by Escherichia coli Bs-1. (1968) (20)
Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products from reaction of melphalan with dGMP and GMP. (1990) (19)
The preparation and properties of some benzylated nucleosides. (1968) (18)
Interaction studies with DNA. IV. The binding of 5-aminoacridine studied fluorimetrically, and its comparison with the binding of rosaniline. (1956) (18)
Direct assay for O6-methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots. (1991) (18)
A monofunctional derivative of melphalan: preparation, DNA alkylation products, and determination of the specificity of monoclonal antibodies that recognize melphalan-DNA adducts. (1998) (17)
Interaction studies with DNA. I. The binding of rosaniline at low ratio of concentrations rosaniline: DNA, and competitive effect of sodium and other metal cations. (1956) (17)
Synthesis of 1-(2-hydroxyethyl)-1-nitrosourea and comparison of its carcinogenicity with that of 1-ethyl-1-nitrosourea. (1979) (14)
Interaction studies with DNA. II. The binding of dimeric and polymeric rosaniline by sodium thymonucleate and the metachromatic effect. (1956) (14)
Crystal Size and Fluorescence Intensity (1949) (14)
The reaction of melphalan with deoxyguanosine and deoxyguanylic acid. (1992) (13)
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen. (1983) (12)
Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine. (1990) (12)
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens. (1973) (12)
"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis. (1975) (11)
Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect. (1988) (11)
Chemical induction of thymomas in AKR mice: Interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of N‐methyl‐N‐nitrosourea and methyl methanesulphonate (1990) (10)
Effects on DNA: Chemical Methods (1971) (10)
Comparative carcinogenicity of alkylating agents: comparisons of a series of alkyl and aralkyl bromides of differing chemical reactivities as inducers of sarcoma at the site of a single injection in the rat. (1981) (9)
From fluorescence spectra to mutational spectra, a historical overview of DNA-reactive compounds. (1994) (7)
Urinary excretion of 3-methyladenine and 1-methylnicotinamide by rats, following administration of [methyl-14C]methyl methanesulphonate and comparison with administration of [14C]methionine or formate. (1985) (7)
The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea. (1994) (7)
Novel uses of mass spectrometry in studies of adducts of alkylating agents with nucleic acids and proteins. (1988) (7)
Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents (1966) (6)
Increased urinary excretion of labelled deoxyribonucleosides in rats with stable pre-labelled DNA treated with methyl methanesulphonate or nitrogen mustard. (1975) (5)
Concepts of carcinogenesis (1987) (4)
Methylation of mu2 bacteriophage ribonucleic acid by the carcinogen N-methyl-N-nitrosourea: evidence for O-methylation. (1971) (4)
ALKYLATING AGENTS. (1964) (4)
The Interaction of Reactive Metabolites with Components of Mammalian Cells (1974) (4)
Increased urinary excretion of pyrimidine and nicotinamide derivatives in rats treated with methyl methanesulphonate. (1974) (3)
Carcinogenesis (target organ toxicology series), M.P. Waalkes, J.M. Ward (Eds.). Raven Press, London (1993), 492 (1994) (2)
Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N' -nitro-N-nitrosoguanidine: lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at 0-6 of guanine. (1976) (2)
Rapid screening of carcinogens — end of the beginning? (1979) (2)
Investigations of tumour-inhibitory styrylquinoline derivatives. (1960) (2)
Letter to the editorInterstrand cross-linking by difunctional alkylating agents (1967) (1)
Methylated bases in liver acids from rats treated with dimethylnitrosamine. (1968) (1)
SYNTHESISAND IDENTIFICATIONOF A NEW METHYLATION PRODUCT, 04-METHYLTHYMIDINE (1973) (0)
Increased sensitivity oflymphocytes frompatients withsystemic autoimmune diseases toDNA alkylation bythemethylating carcinogen N-methyl-N-nitro sourea (1988) (0)
Relative carcinogenic effectiveness of n-methyl-n- -nitrosourea (mnua) and n-ethyl-n-nitrosourea (enua). Quantitative relation to alkylatioon of 0-6 of guanine in dna. Abstr. (1978) (0)
Methylation of Cellular DNA by the Carcinogen N-Methyl-N-Nitrosourea and Removal of Methylpurines — Comparisons of Escherichia coli, Mouse and Human Cells (1981) (0)
Alkylation of dna of target tissues of mice at doses of alkylating agents which induce low yields of thymic lymphomas. Abstr. (1977) (0)
ALKYLATING AGENTS AND NUCLEIC ACIDS 1946 ) and subsequently of a wide variety of alkylating agents (2005) (0)
Defective removal of O6-methylguanine (O6-MeG) from the DNA of lymphocytes treated with N-methyl-N-nitrosourea (MNU) in autoimmune diseases (1982) (0)
The Economics of Small Farms (1983) (0)
Mouse strain differences in thymoma induction by methyl- nitrosourea. Abstr. (1980) (0)
Bone marrow and thymus depletion in rfm and c57bl mice by n-methyl-n-nitrosourea in relation to yield of thymic lymphomas and methylation of dna. Abstr. (1979) (0)
Nature of Alkylation Lesions and Their Repair: Significance for Ideas on Mutagenesis (2008) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Philip D. Lawley?

Philip D. Lawley is affiliated with the following schools: