Philip Ph G. De Groot
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Philip Ph G. De Grootbiology Degrees
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Biology
Philip Ph G. De Groot's Degrees
- PhD Immunology University of Amsterdam
- Masters Biomedical Sciences University of Amsterdam
- Bachelors Biology University of Amsterdam
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(Suggest an Edit or Addition)Philip Ph G. De Groot's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) (2006) (4892)
- Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. (2002) (1813)
- Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines (2003) (743)
- Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2). (2002) (660)
- Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients (2009) (585)
- Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain (2002) (545)
- Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? (1993) (523)
- Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity (2006) (519)
- A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components. (1983) (445)
- IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. (2005) (379)
- Nitric Oxide Functions as an Inhibitor of Platelet Adhesion Under Flow Conditions (1992) (348)
- Adhesion mechanism of human β2‐glycoprotein I to phospholipids based on its crystal structure (1999) (344)
- Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. (2010) (313)
- Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients (2008) (306)
- F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis. (2012) (304)
- Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis. (2001) (285)
- Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis. (2004) (271)
- The association between circulating antibodies against domain I of beta2‐glycoprotein I and thrombosis: an international multicenter study (2009) (268)
- Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women. (1999) (262)
- Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation. (2008) (257)
- Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin). (1994) (255)
- Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. (2010) (254)
- Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. (1993) (250)
- Glycation Induces Formation of Amyloid Cross-β Structure in Albumin* (2003) (242)
- Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients. (2009) (240)
- Von Willebrand factor in the vessel wall mediates platelet adherence. (1985) (238)
- beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. (2004) (232)
- Dimers of β2-Glycoprotein I Increase Platelet Deposition to Collagen via Interaction with Phospholipids and the Apolipoprotein E Receptor 2′* (2003) (229)
- 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends. (2014) (224)
- Haemostatic abnormalities in patients with liver disease. (2002) (222)
- The Complexity of the Phospholipid Binding Protein Annexin V (1995) (219)
- Lupus anticoagulants and the risk of a first episode of deep venous thrombosis (2005) (215)
- Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change. (2006) (198)
- Increased platelet deposition on atherosclerotic coronary arteries. (1994) (192)
- Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2. (2011) (183)
- Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions. (2008) (174)
- Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A. (2002) (165)
- A3 Domain Is Essential for Interaction of von Willebrand Factor with Collagen Type III (1996) (165)
- A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies. (1992) (163)
- The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells. (1983) (160)
- P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor. (2006) (156)
- Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients. (1988) (155)
- Media conditioned by cultured human vascular endothelial cells inhibit the growth of vascular smooth muscle cells. (1982) (151)
- A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B. (2005) (148)
- The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. (2003) (139)
- Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood. (1990) (138)
- Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations. (2016) (133)
- Role of ADP Receptor P2Y12 in Platelet Adhesion and Thrombus Formation in Flowing Blood (2002) (130)
- The significance of autoantibodies against β2-glycoprotein I. (2012) (129)
- Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa. (1985) (128)
- Subendothelial Proteins and Platelet Adhesion: von Willebrand Factor and Fibronectin, Not Thrombospondin, Are involved in Platelet Adhesion to Extracellular Matrix of Human Vascular Endothelial Cells (1986) (122)
- Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5. (2007) (122)
- An Experimental Model to Study the in Vivo Survival of von Willebrand Factor (2004) (119)
- Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. (2004) (119)
- Acute activation of the endothelium results in increased levels of active von Willebrand factor in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome (2006) (118)
- A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. (2006) (117)
- Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor-independent thrombin generation. (2003) (115)
- Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on the Risk of a First Venous Thrombosis (2008) (115)
- beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation. (2007) (115)
- Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria. (2007) (113)
- Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. (2011) (113)
- The binding of high molecular weight kininogen to cultured human endothelial cells. (1988) (112)
- Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis (2020) (109)
- Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. (2010) (109)
- Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis (2007) (106)
- Circulating Biomarkers for Predicting Cardiovascular Disease Risk; a Systematic Review and Comprehensive Overview of Meta-Analyses (2013) (105)
- Cell cycle-dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E1. (1985) (105)
- Activation of endothelial cells induces platelet thrombus formation on their matrix. Studies of new in vitro thrombosis model with low molecular weight heparin as anticoagulant. (1990) (104)
- Factor VIII half-life and clinical phenotype of severe hemophilia A. (2005) (101)
- β₂-glycoprotein I: a novel component of innate immunity. (2011) (101)
- The obstetric antiphospholipid syndrome. (2006) (99)
- Functional domains on von Willebrand factor. Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen. (1984) (96)
- A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia. (2008) (94)
- Plasminogen activator inhibitor 4G polymorphism is associated with decreased risk of cerebrovascular mortality in older women. (2000) (93)
- Increased Thromboxane Biosynthesis in Patients With Acute Cerebral Ischemia (1993) (92)
- Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin. (1994) (91)
- ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria. (2009) (89)
- Cigarette Smoke Impairs Endothelial Cell Prostacyclin Production (1986) (89)
- Characterization of 25 monoclonal antibodies to factor VIII-von Willebrand factor: relationship between ristocetin-induced platelet aggregation and platelet adherence to subendothelium. (1984) (88)
- The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma. (2011) (88)
- A simple method to discriminate between β2‐glycoprotein I‐ and prothrombin‐dependent lupus anticoagulants (2003) (87)
- Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome. (2008) (86)
- Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men. (2010) (85)
- Immune responses against domain I of β(2)-glycoprotein I are driven by conformational changes: domain I of β(2)-glycoprotein I harbors a cryptic immunogenic epitope. (2011) (85)
- Platelet adhesion to collagen type IV under flow conditions. (1996) (83)
- Thrombin-induced release of von Willebrand factor from endothelial cells is mediated by phospholipid methylation. Prostacyclin synthesis is independent of phospholipid methylation. (1984) (83)
- Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces. (1998) (81)
- Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia. (2013) (81)
- Platelet adhesion to fibronectin in flow: the importance of von Willebrand factor and glycoprotein Ib. (1995) (80)
- Heparin immobilization reduces thrombogenicity of small-caliber expanded polytetrafluoroethylene grafts. (2006) (80)
- Isolation of a storage and secretory organelle containing Von Willebrand protein from cultured human endothelial cells. (1984) (79)
- High von Willebrand factor concentration compensates a relative adhesion defect in uremic blood. (1990) (78)
- The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface. (2008) (78)
- Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels. (2007) (78)
- Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor-glycoprotein Ib interaction and inhibited by von Willebrand factor-glycoprotein IIb/IIIa interaction. (2000) (77)
- Interference with the Host Haemostatic System by Schistosomes (2013) (77)
- Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins. (1992) (76)
- Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability. (2012) (76)
- Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study. (1998) (75)
- Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen. (1988) (75)
- Role of the glycoprotein Ib-binding A1 repeat and the RGD sequence in platelet adhesion to human recombinant von Willebrand factor. (1995) (74)
- Complexes of anti‐prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces (2001) (74)
- Protein S binding to human endothelial cells is required for expression of cofactor activity for activated protein C. (1993) (74)
- beta2-glycoprotein I, the playmaker of the antiphospholipid syndrome. (2004) (74)
- Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation (2002) (74)
- Dimers of β2-Glycoprotein I Mimic thein Vitro Effects of β2-Glycoprotein I-Anti-β2-glycoprotein I Antibody Complexes* (2001) (74)
- Plasmin Cleavage of von Willebrand Factor as an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy (2014) (73)
- Glycation induces formation of amyloid cross-beta structure in albumin. (2003) (73)
- Reduced plasma fibrinolytic capacity as a potential risk factor for a first myocardial infarction in young men (2009) (71)
- Interaction of blood platelets with the vessel wall. (1988) (70)
- Reconstitution of the vascular wall in vitro. A novel model to study interactions between endothelial and smooth muscle cells. (1986) (69)
- Accumulation of weak bases in relation to intralysosomal pH in cultured human skin fibroblasts. (1981) (69)
- Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. (2010) (68)
- Comparison of secretion and subcellular localization of von Willebrand protein with that of thrombospondin and fibronectin in cultured human vascular endothelial cells. (1985) (68)
- Antibodies to platelets in patients with anti-phospholipid antibodies. (1991) (68)
- Binding of recombinant annexin V to endothelial cells: effect of annexin V binding on endothelial-cell-mediated thrombin formation. (1994) (68)
- Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity (2014) (67)
- Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13 (2012) (67)
- Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins. (1993) (67)
- Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGF1 alpha excretion in healthy subjects. (1987) (66)
- The Binding Site in β2-Glycoprotein I for ApoER2′ on Platelets Is Located in Domain V* (2005) (66)
- Plasma Protein β-2-Glycoprotein 1 Mediates Interaction between the Anti-tumor Monoclonal Antibody 3G4 and Anionic Phospholipids on Endothelial Cells* (2006) (66)
- High-molecular weight kininogen is present in cultured human endothelial cells: localization, isolation, and characterization. (1988) (66)
- Prevalence of antiphospholipid antibodies in patients with fetal loss. (1991) (66)
- The presence of active von Willebrand factor under various pathological conditions (2007) (65)
- A new perfusion chamber to detect platelet adhesion using a small volume of blood. (1998) (65)
- Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets. (2014) (64)
- Binding of vitronectin-thrombin-antithrombin III complex to human endothelial cells is mediated by the heparin binding site of vitronectin. (1992) (63)
- Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor (2012) (63)
- The impact of the fibrinolytic system on the risk of venous and arterial thrombosis. (2009) (63)
- Interplay between platelets and coagulation (2020) (62)
- Storage and secretion of von Willebrand factor by endothelial cells. (1988) (61)
- Risk factors for thrombosis in lupus patients. (1989) (61)
- Annexin A5 polymorphism (−1C→T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome (2006) (61)
- Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis (2015) (61)
- Identification of Coagulation Factor XI as a Ligand for Platelet Apolipoprotein E Receptor 2 (ApoER2) (2009) (61)
- Platelet function alterations in dengue are associated with plasma leakage (2014) (60)
- Regulation of von Willebrand factor-platelet interactions (2010) (60)
- Absence of Fibrinogen in Afibrinogenemia Results in Large but Loosely Packed Thrombi under Flow Conditions (2001) (60)
- Pregnancy in Systemic Lupus Erythematosus: a Prospective Study (1994) (60)
- β2-Glycoprotein I Is Proteolytically Cleaved In Vivo upon Activation of Fibrinolysis (1999) (59)
- Perturbation of human endothelial cells by thrombin or PMA changes the reactivity of their extracellular matrix towards platelets (1987) (58)
- Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. (2010) (58)
- Fluctuations of anticardiolipin antibody levels in patients with systemic lupus erythematosus: a prospective study. (1989) (57)
- Platelet adhesion to multimeric and dimeric von Willebrand factor and to collagen type III preincubated with von Willebrand factor. (1996) (56)
- Treatment of Uremic Anemia with Recombinant Erythropoietin also Reduces the Defects in Platelet Adhesion and Aggregation Caused by Uremic Plasma (1991) (56)
- New Insights into the Role of Erythrocytes in Thrombus Formation (2013) (55)
- Activation of the coagulation mechanism on tumor necrosis factor-stimulated cultured endothelial cells and their extracellular matrix. The role of flow and factor IX/IXa. (1991) (54)
- Antiphospholipid Syndrome–Not a Noninflammatory Disease (2015) (54)
- Inhibition of Platelet Adhesion to Fibrin(ogen) in Flowing Whole Blood by Arg-Gly-Asp and Fibrinogen γ-Chain Carboxy Terminal Peptides (1992) (51)
- Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts. (2014) (51)
- Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions. (1994) (50)
- Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in men (2009) (50)
- Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy (2010) (49)
- Thrombogenicity of vascular cells. Comparison between endothelial cells isolated from different sources and smooth muscle cells and fibroblasts. (1990) (49)
- Defects in platelet adhesion and aggregate formation in uremic bleeding disorder can be attributed to factors in plasma. (1991) (49)
- Analysis of thrombotic factors in severe acute respiratory syndrome (SARS) patients (2006) (49)
- Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitemia. (2015) (48)
- The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction. (1998) (48)
- Platelet aggregation: involvement of thrombin and fibrin(ogen). (2005) (48)
- The proteome of the insoluble Schistosoma mansoni eggshell skeleton. (2011) (48)
- Antiphospholipid antibodies--we are not quite there yet. (2011) (47)
- Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses (2015) (47)
- On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. (1995) (47)
- Role of plasma viscosity in platelet adhesion. (1992) (46)
- Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. (1980) (46)
- FLow-Induced PRotrusions (FLIPRs): A Platelet-Derived Platform for the Retrieval of Microparticles by Monocytes and Neutrophils (2014) (46)
- Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome. (2014) (45)
- Shear-stress-induced detachment of blood platelets from various surfaces. (1997) (45)
- Fibrinolysis and the risk of venous and arterial thrombosis (2007) (44)
- Prospective study of fluctuations of lupus anticoagulant activity and anticardiolipin antibody titre in patients with systemic lupus erythematosus. (1992) (44)
- Platelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV. (1994) (44)
- Binding of von Willebrand Factor to Collagen Type III: Role of Specific Amino Acids in the Collagen Binding Domain of vWF and Effects of Neighboring Domains (2000) (43)
- Twenty-two years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome. (2008) (43)
- A fifty percent reduction of platelet surface glycoprotein Ib does not affect platelet adhesion under flow conditions. (1998) (43)
- von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets. (1989) (43)
- Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages (2007) (42)
- Salvianolic acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor alpha2beta1. (2008) (42)
- Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma (2010) (42)
- Arachidonate metabolism in cultured human vascular endothelial cells. Evidence for two prostaglandin synthetic pathways sensitive to acetylsalicylic acid. (1982) (41)
- Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin. (1996) (40)
- The antibacterial activity of peptides derived from human beta‐2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes (2008) (40)
- Hypofibrinolysis during induction treatment of multiple myeloma may increase the risk of venous thrombosis (2005) (40)
- Functional studies on platelet adhesion with recombinant von Willebrand factor type 2B mutants R543Q and R543W under conditions of flow. (1997) (40)
- Ternary vitronectin-thrombin-antithrombin III complexes in human plasma. Detection and mode of association. (1993) (40)
- Effect of Extracellular Matrix Glycation on Endothelial Cell Adhesion and Spreading: Involvement of Vitronectin (1997) (40)
- von Willebrand factor and the blood vessel wall. (1991) (39)
- Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin. (2004) (39)
- Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network* (2014) (39)
- Thrombopoietin increases platelet adhesion under flow and decreases rolling (2003) (38)
- The (non‐)sense of detecting anti‐cardiolipin and anti‐β2glycoprotein I IgM antibodies in the antiphospholipid syndrome (2020) (38)
- Up-regulation of platelet activation in hemophilia A (2011) (38)
- Platelet interaction with the vessel wall. (2012) (37)
- Homozygosity for 807 T polymorphism in alpha(2) subunit of platelet alpha(2)beta(1) is associated with increased risk of cardiovascular mortality in high-risk women. (2000) (37)
- Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men. (2009) (37)
- Heat treatment of serum and plasma induces false positive results in the antiphospholipid antibody ELISA. (1990) (37)
- Absence of ligands bound to glycoprotein IIB-IIIA on the exposed surface of a thrombus may limit thrombus growth in flowing blood. (1994) (37)
- Variability in Exposure of Epitope G40-R43 of Domain I in Commercial Anti-Beta2-Glycoprotein I IgG ELISAs (2013) (36)
- Characterization of the Philadelphia chromosome by gene mapping. (1981) (36)
- Platelet Activation Determines Angiopoietin-1 and VEGF Levels in Malaria: Implications for Their Use as Biomarkers (2013) (36)
- Autoantibodies Directed Against Domain I of Beta2-Glycoprotein I (2010) (36)
- Antiphospholipid antibodies: update on detection, pathophysiology, and treatment (2004) (36)
- Induction of anti‐β2‐glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes (2011) (36)
- Shear-Resistant Binding to von Willebrand Factor Allows Staphylococcus lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis. (2016) (35)
- The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans (2018) (35)
- Comparison of Platelet Interaction with Subendothelium of Human Renal and Umbilical Arteries and the Extracellular Matrix Produced by Human Venous Endothelial Cells (1984) (35)
- Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men (2016) (35)
- Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients (2009) (34)
- Role of von Willebrand factor in the vessel wall. (1987) (34)
- Enhancement of fibrinolytic potential in vitro by anticoagulant drugs targeting activated factor X, but not by those inhibiting thrombin or tissue factor (2003) (34)
- Thrombogenicity and procoagulant activity of human mesothelial cells. (1992) (33)
- Endocannabinoids Control Platelet Activation and Limit Aggregate Formation under Flow (2014) (33)
- New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats (2018) (32)
- Glycoprotein Ibα–Mediated Platelet Adhesion and Aggregation to Immobilized Thrombin Under Conditions of Flow (2005) (32)
- From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndrome. (2013) (32)
- Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy. (2004) (32)
- The prevalence of a non-phospholipid-binding form of beta2-glycoprotein I in human plasma--consequences for the development of anti-beta2-glycoprotein I antibodies. (1998) (31)
- von Willebrand Factor without the A2 Domain Is Resistant to Proteolysis (1997) (31)
- A review of pulmonary coagulopathy in acute lung injury, acute respiratory distress syndrome and pneumonia (2009) (31)
- Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue (2019) (31)
- Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation. (2004) (30)
- Platelet adhesion to fibrin(ogen). (1993) (30)
- Increased high molecular weight fibrinogen in pre-eclampsia. (2003) (29)
- Thrombogenicity of the human arterial wall after interventional thermal injury. (1996) (29)
- Thrombin regulation by physiological inhibitors: the role of vitronectin. (1996) (29)
- A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia-associated antibodies in humans. (2008) (29)
- Interleukin‐l Inhibits the Synthesis of von Willebrand Factor in Endothelial Cells, Which Results in a Decreased Reactivity of Their Matrix toward Platelets (1987) (29)
- Cyclotriveratrylene (CTV) as a new chiral triacid scaffold capable of inducing triple helix formation of collagen peptides containing either a native sequence or Pro-Hyp-Gly repeats. (2002) (29)
- Higher platelet reactivity and platelet-monocyte complex formation in Gram-positive sepsis compared to Gram-negative sepsis (2017) (29)
- Internalization of Vitronectin-Thrombin-Antithrombin Complex by Endothelial Cells Leads to Deposition of the Complex into the Subendothelial Matrix (*) (1995) (28)
- Cyclosporine is associated with endothelial dysfunction but not with platelet activation in renal transplantation. (2001) (28)
- FRETS‐VWF73: a rapid and predictive tool for thrombotic thrombocytopenic purpura (2006) (28)
- Tests for lupus anticoagulant revisited. (2004) (28)
- Vessel wall proteins adhesive for platelets. (1991) (28)
- Elevated plasma tissue-type plasminogen activator (t-PA) and soluble thrombomodulin in patients suffering from severe acute respiratory syndrome (SARS) as a possible index for prognosis and treatment strategy. (2005) (28)
- Perturbation of cultured human vascular endothelial cells by phorbol ester or thrombin alters the cellular von Willebrand factor distribution (1987) (27)
- The Lupus Anticoagulant Paradox (2017) (27)
- Enhanced in vitro procoagulant and antifibrinolytic potential of superactive variants of recombinant factor VIIa in severe hemophilia A (2003) (27)
- Platelet adhesion to cyanogen-bromide fragments of collagen alpha 1(I) under flow conditions. (1993) (27)
- Adhesion of blood platelets is inhibited by VCL, a recombinant fragment (leucine504 to lysine728) of von Willebrand factor. (1996) (26)
- Evolutionary conservation of the lipopolysaccharide binding site of β2-glycoprotein I (2011) (26)
- Plasma fibrinogen inhibits platelets adhesion in flowing blood to immobilized fibrinogen. (1996) (26)
- Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF. (2007) (26)
- Patient‐derived monoclonal antibodies directed towards beta2 glycoprotein‐1 display lupus anticoagulant activity (2011) (26)
- Thrombin‐activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis (2010) (25)
- The Future of Antiphospholipid Antibody Testing (2012) (25)
- Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity (2011) (25)
- Glycated proteins modulate tissue-plasminogen activator-catalyzed plasminogen activation. (1997) (24)
- Clot lysis time and the risk of myocardial infarction and ischaemic stroke in young women; results from the RATIO case–control study (2012) (24)
- Mechanisms of thrombosis in systemic lupus erythematosus and antiphospholipid syndrome. (2017) (24)
- Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin. (2018) (24)
- The effect of recombinant IgG antibodies against the leucine-33 form of the platelet β3 integrin (HPA-1a) on platelet function (2004) (24)
- Platelet adhesion to collagen in healthy volunteers is influenced by variation of both alpha(2)beta(1) density and von Willebrand factor. (2000) (23)
- The in vitro effect of the new antithrombotic drug candidate ALX-0081 on blood samples of patients undergoing percutaneous coronary intervention (2011) (23)
- Optimisation of lupus anticoagulant tests: should test samples always be mixed with normal plasma? (2014) (23)
- β2‐Glycoprotein I is incorrectly named apolipoprotein H (2009) (22)
- Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13 (2015) (22)
- Contact System Activation on Endothelial Cells (2014) (22)
- Platelet Adhesion and Aggregate Formation in Type I Diabetes Under Flow Conditions (1991) (22)
- The influence of the pulsatility of the blood flow on the extent of platelet adhesion. (2008) (22)
- Differential platelet adhesion to distinct life‐cycle stages of the parasitic helminth Schistosoma mansoni (2007) (22)
- Adhesive properties of the carbohydrate-modified von Willebrand factor (CHO-vWF). (1988) (22)
- Protein C Pathway, Antiphospholipid Antibodies and Thrombosis (1994) (21)
- Reduced platelet adhesion in flowing blood to fibrinogen by alterations in segment γ316–322, part of the fibrin‐specific region * (2002) (21)
- The ideal anti-thrombotic drug. (1992) (21)
- Beta2-glycoprotein I and LDL-receptor family members. (2004) (21)
- Platelet-monocyte interaction in Mycobacterium tuberculosis infection. (2018) (21)
- Quantification of fibrin deposition in flowing blood with peroxidase-labeled fibrinogen. High shear rates induce decreased fibrin deposition and appearance of fibrin monomers. (1991) (20)
- Effect of 2-deoxyglucose on lysosomal enzymes in cultured human skin fibroblasts. (1980) (20)
- Targeted Phosphotyrosine Profiling of Glycoprotein VI Signaling Implicates Oligophrenin-1 in Platelet Filopodia Formation (2013) (20)
- Formation of meizothrombin as intermediate in factor Xa-catalyzed prothrombin activation on endothelial cells. The influence of thrombin on the reaction mechanism. (1991) (20)
- Anti-Domain I β2-Glycoprotein I Antibodies and Activated Protein C Resistance Predict Thrombosis in Antiphospholipid Syndrome: TAC(I)T Study. (2020) (20)
- Pathophysiology of antiphospholipid antibodies. (2004) (19)
- Adhesive Domains in the Collagen III Fragment α1(III)CB4 that Support α2β1- and von Willebrand Factor-mediated Platelet Adhesion under Flow Conditions (1999) (19)
- Platelet adhesion to vascular cells. The role of exogenous von Willebrand factor in platelet adhesion. (1990) (19)
- Chlamydia trachomatis Infection of Human Mesothelial Cells Alters Proinflammatory, Procoagulant, and Fibrinolytic Responses (1998) (19)
- Increased cytokine response after toll-like receptor stimulation in patients with stable coronary artery disease. (2013) (19)
- Antiphospholipid antibodies: specificity and pathophysiology. (1993) (18)
- Methylenetetrahydrofolate reductase 677 C/T genotype and cardiovascular disease mortality in postmenopausal women. (2001) (18)
- Elevated levels of D-dimer and fragment 1+2 upon central venous catheter insertion and factor V Leiden predict subclavian vein thrombosis. (2005) (18)
- Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation? (2000) (18)
- A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation (2016) (18)
- The role of thrombin in the regulation of the endothelial prostaglandin production. (1985) (17)
- Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2020) (17)
- Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery. (2013) (17)
- Recombinant vWF Type 2A Mutants R834Q and R834W Show a Defect in Mediating Platelet Adhesion to Collagen, Independent of Enhanced Sensitivity to a Plasma Protease (1999) (17)
- Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis (2017) (17)
- Cultured Endothelial Cells Regulate Platelet Adhesion to their Extracellular Matrix by Regulating its von Willebrand Factor Content (1995) (17)
- Chronic dysfunction of the endothelium is associated with mortality in acute coronary syndrome patients. (2013) (17)
- The effect of recombinant human erythropoietin on hemostasis, fibrinolysis, and blood rheology in autologous blood donors. (1994) (16)
- Factor V Arg506Gln mutation is not associated with cardiovascular mortality in older women. (1999) (16)
- The antiphospholipid syndrome: clinical characteristics, laboratory features and pathogenesis (2005) (16)
- Binding of von Willebrand factor and plasma proteins to the eggshell of Schistosoma mansoni. (2014) (16)
- SARS in Hong Kong. (2003) (15)
- Increased factor XIa levels in patients with a first acute myocardial infarction: the introduction of a new thrombin generation based factor XIa assay. (2014) (15)
- Suitability of low-molecular-weight heparin(oid)s and a pentasaccharide for an in vitro human thrombosis model. (1994) (15)
- Anti‐β2‐glycoprotein I and anti‐prothrombin antibodies cause lupus anticoagulant through different mechanisms of action (2021) (15)
- Detection of anti‐domain I antibodies by chemiluminescence enables the identification of high‐risk antiphospholipid syndrome patients: A multicenter multiplatform study (2019) (15)
- Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia (2021) (15)
- Aggregate formation is more strongly inhibited at high shear rates by dRGDW, a synthetic RGD-containing peptide. (1993) (15)
- Evidence that fibrin alpha-chain RGDX sequences are not required for platelet adhesion in flowing whole blood. (1995) (15)
- Clinical consequences of antiphospholipid antibodies. (2004) (14)
- Increased active von Willebrand factor during disease development in the aging diabetic patient population (2011) (14)
- Both increased and decreased platelet adhesion to thermally injured subendothelium is caused by denaturation of von Willebrand factor. (1993) (14)
- Analytical characterization and reference interval of an enzyme-linked immunosorbent assay for active von Willebrand factor (2019) (14)
- Tissue factor-independent effects of recombinant factor VIIa on hemostasis. (2008) (14)
- The antiphospholipid syndrome: clinical characteristics, laboratory features and pathogenesis. (2005) (13)
- Prolonged bleeding time and lupus anticoagulant: a second paradox in the antiphospholipid syndrome. (2004) (13)
- The role of cell surfaces and cellular receptors in the mode of action of recombinant factor VIIa. (2015) (13)
- Platelet Adhesion to Subendothelial Structures under Flow Conditions: No Effect of the Lipoxygenase Product 13-HODE (1989) (13)
- Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases. (2018) (12)
- Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors. (2002) (12)
- The effect of P2Y12 inhibition on platelet activation assessed with aggregation- and flow cytometry-based assays (2017) (10)
- Antiphospholipid syndrome (2010) (10)
- Platelets as pivot in the antiphospholipid syndrome. (2014) (10)
- Thrombocytopenia and Platelet Dysfunction in Acute Tropical Infectious Diseases (2018) (10)
- Sustained pro-haemostatic activity of rFVIIa in plasma and platelets in non-bleeding pigs may explain the efficacy of a once-daily prophylaxis in humans (2014) (10)
- Lupus anticoagulant in cardiovascular diseases: the role of beta2-glycoprotein I. (2000) (10)
- A switch to a raltegravir containing regimen does not lower platelet reactivity in HIV-infected individuals (2018) (9)
- Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B (2010) (9)
- Increased Platelet Reactivity Is Associated with Circulating Platelet-Monocyte Complexes and Macrophages in Human Atherosclerotic Plaques (2014) (9)
- The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding (2016) (9)
- beta 2 Glycoprotein I--a key player in the antiphospholipid syndrome. (2002) (9)
- Increased Platelet-Monocyte Interaction in Stable COPD in the Absence of Platelet Hyper-Reactivity (2017) (9)
- Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II (2002) (9)
- Long-term treated HIV infection is associated with platelet mitochondrial dysfunction (2021) (9)
- Role of glycoprotein IIb:IIIa in the adhesion of platelets to collagen under flow conditions. (1997) (9)
- Interventional Thermal Injury of the Arterial Wall: Unfolding of von Willebrand Factor and Its Increased Binding to Collagen after 55° C Heating (1996) (9)
- Mechanisms of anti-phospholipid antibody formation and action. (2011) (9)
- Ascorbic Acid Increases the Thrombogenicity of Cellular Matrices (1991) (8)
- Haemostatic changes in urogenital schistosomiasis haematobium: a case-control study in Gabonese schoolchildren. (2019) (8)
- Platelet adhesion to the subendothelium under flow. (1999) (7)
- In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact (2015) (7)
- Antiphospholipid Antibodies and the Risk of Stroke in Urban and Rural Tanzania: A Community-Based Case–Control Study (2016) (7)
- Endothelial and smooth muscle cells in the heart allograft response: isolation procedure and immunocytochemical features. (1991) (7)
- Antiprothrombin antibodies induce platelet activation: A possible explanation for anti‐FXa therapy failure in patients with antiphospholipid syndrome? (2021) (7)
- [Activity loss of Von Willebrand factor cleaving protein (ADAMTS-13) is diagnostic for primary and pregnancy-related thrombotic thrombocytopenic purpura]. (2004) (6)
- The role of von Willebrand factor in platelet function. (2002) (6)
- Molecular basis of congenital afibrinogenaemia in a Dutch family (2003) (6)
- Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma (2018) (6)
- The Relationship between Fractional Flow Reserve, Platelet Reactivity and Platelet Leukocyte Complexes in Stable Coronary Artery Disease (2013) (6)
- Genome scan of clot lysis time and its association with thrombosis in a protein C‐deficient kindred (2011) (6)
- In vivo experiments indicate that relatively high platelet deposition in von Willebrand's disease 'Vicenza' is caused by normal platelet-VWF levels rather than by high VWF-multimers in plasma. (1992) (6)
- Platelet degranulation and glycoprotein IIbIIIa opening are not related to bleeding phenotype in severe haemophilia A patients (2014) (6)
- Detection of the lupus anticoagulant in pregnancy. (1992) (6)
- The interaction of recombinant factor VIIa with platelet glycoprotein Ib. (2010) (6)
- β-radiation reduces the reactivity of extracellular matrix proteins in intravascular brachytherapy (IVBT), resulting in decreased platelet adhesion. (2012) (6)
- Higher and lower active circulating VWF levels: different facets of von Willebrand disease (2015) (5)
- Anti-phospholipid antibodies and vascular pathology. (1994) (5)
- The presence of anti-beta 2-glycoprotein I and anti-prothrombin antibodies and their correlations with venous and arterial thrombosis. (1996) (5)
- Annexin A5 haplotypes in the antiphospholipid syndrome. (2015) (5)
- Active von Willebrand factor and the risk of stroke. (2010) (5)
- The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo (2018) (5)
- Loss of blood platelet adhesion after heating native and cultured human subendothelium to 100 degrees Celcius. (1990) (5)
- Successful soft and hard tissue augmentation with platelet‐rich fibrin in combination with bovine bone space maintainer in a delayed implant placement protocol in the esthetic zone: A case report (2019) (4)
- Platelet Integrin αIIbβ3 Activation is Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults (2020) (4)
- Nature of the fibrinogen Aalpha gene TaqI polymorphism. (2001) (3)
- Endothelial cell-mediated thrombin formation. (1992) (3)
- Localization of a gene for human alpha-galactosidase B (= n-acetyl-alpha-d-galactosaminidase) on chromosome 22. (1978) (3)
- Deciphered coagulation profile to diagnose the antiphospholipid syndrome using artificial intelligence. (2021) (3)
- Internalization of antithrombin III by cultured human endothelial cells and its subcellular localization. (1989) (3)
- Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions. (2001) (3)
- Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells (2021) (3)
- Implant stability in patients treated with platelet‐rich fibrin and bovine bone substitute for alveolar ridge preservation is associated with peripheral blood cells and coagulation factors (2019) (3)
- Impaired platelet adhesion to lysed fibrin, whereas neutrophil adhesion remains intact under conditions of flow (2006) (3)
- Resonance frequency analysis with two different devices after conventional implant placement with ridge preservation: A prospective pilot cohort study. (2021) (3)
- Salivary tissue factor induces thrombin generation in a diurnal rhythm (2018) (3)
- Human recombinant alkaline phosphatase inhibits ex vivo platelet activation in humans (2016) (3)
- Acute exacerbations of COPD are associated with a prothrombotic state through platelet-monocyte complexes, endothelial activation and increased thrombin generation. (2020) (3)
- Plasmatic Coagulation Capacity Correlates With Inflammation and Abacavir Use During Chronic HIV Infection (2021) (3)
- Serotonin, key to thrombocytopenia in dengue? (2019) (2)
- AB0561 Needs-Assessment Survey for the Update of the Current Antiphospholipid Syndrome (APS) Classification Criteria (2015) (2)
- Response to letter regarding article, "plasmin cleavage of von willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy". (2015) (2)
- Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non‐genetic factors (2022) (2)
- Untargeted Plasma Metabolomics and Gut Microbiome Profiling Provide Novel Insights into the Regulation of Platelet Reactivity in Healthy Individuals (2021) (2)
- Kallikrein augments the anticoagulant function of the protein C system in thrombin generation (2021) (2)
- Inactivation by chloroquine of alpha-galactosidase in cultured human skin fibroblasts. (1981) (2)
- Relapsing splenic vein thrombosis associated with antiphospholipid antibodies in a patient with wegener granulomatosis. (2007) (2)
- PRIMARY BINDING SITE OF VON WILLEBRAND FACTOR IN THE SUBENDOTHELIUM WHICH MEDIATES PLATELET ADHESION IS NOT COLLAGEN (1987) (1)
- Homozygosity for 807 T Polymorphism in &agr;2 Subunit of Platelet &agr;2&bgr;1 Is Associated With Increased Risk of Cardiovascular Mortality in High-Risk Women (2000) (1)
- Suppressing platelet microparticle formation by antibodies against platelet glycoprotein GPIb (2007) (1)
- The effects of signal transducer and activator of transcription three mutations on human platelets (2018) (1)
- KINETIC BEHAVIOUR OF VON WILLEBRAND FACTOR AND FIBRONECTIN EXPLAINS DEPENDENCE OF PLATELET ADHESION ON PHYSICAL PARAMETERS (1987) (1)
- Platelet-Vessel Wall Interaction (1993) (1)
- Platelet Activation via Glycoprotein VI Initiates Thrombin Generation: A Potential Role for Platelet-Derived Factor IX? (2022) (0)
- [Adhesion of blood platelets. II. Adhesive proteins and their receptors: physiology and pathology]. (1989) (0)
- Increased active von Willebrand factor during disease development in the aging diabetic patient population (2011) (0)
- Platelet adhesion. (1995) (0)
- [Blood platelet adhesion. I. Adhesion to the vascular wall and the role of platelet transport]. (1989) (0)
- Further characterization of two forms of N-acetyl-alpha-galactosaminidase from human liver. (1978) (0)
- AUTHORS' REPLY (1994) (0)
- Brief Report on the 11th Meeting of the European Forum on Antiphospholipid Antibodies (2019) (0)
- Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection (2022) (0)
- PERTURBATION OF ENDOTHELIAL CELLS INDUCES THROMBIN FORMATION IN FLOWING BLOOD RESULTING IN PLATELET AGGREGATION ON THEIR MATRIX (1987) (0)
- Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability (2022) (0)
- The antiphospholipid syndrome finally fathomed? (2018) (0)
- No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury. (2018) (0)
- PLATELET ADHESION AND THROMBIN DEPENDENT AGGREGATION OF PATIENTS WITH AN UREMIC BLEEDING TENDENCY (1987) (0)
- Neural Network Diagnoses the Antiphospholipid Syndrome without Interrupting Anticoagulant Therapy (2022) (0)
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