Peter J. Roughley

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Peter J. Roughley

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Peter J. Roughley

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Engineering
Philosophy

Peter J. Roughley's Degrees

Doctorate Medicine Stanford University

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Peter J. Roughley's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

What is Intervertebral Disc Degeneration, and What Causes It? (2006) (1491)
Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix (2004) (694)
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans (2007) (612)
Cartilage in normal and osteoarthritis conditions. (2008) (529)
Type V Osteogenesis Imperfecta: A New Form of Brittle Bone Disease (2000) (448)
Osteogenesis Imperfecta Type VI: A Form of Brittle Bone Disease with a Mineralization Defect (2002) (396)
The structure and function of cartilage proteoglycans. (2006) (382)
Cartilage proteoglycans: Structure and potential functions (1994) (341)
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis (2014) (311)
Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc. (2004) (295)
Aggrecan degradation in human intervertebral disc and articular cartilage. (1997) (262)
Tumor Necrosis Factor&agr; Modulates Matrix Production and Catabolism in Nucleus Pulposus Tissue (2005) (260)
The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. (2006) (252)
Osteogenesis imperfecta type VII: an autosomal recessive form of brittle bone disease. (2002) (244)
Age-related changes in the structure of the proteoglycan subunits from human articular cartilage. (1980) (231)
Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer. (2003) (229)
Experiments in the biosynthesis of curcumin (1973) (223)
The Potential and Limitations of a Cell-Seeded Collagen/Hyaluronan Scaffold to Engineer an Intervertebral Disc-Like Matrix (2003) (222)
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro. (1995) (216)
The role of aggrecan in normal and osteoarthritic cartilage (2014) (216)
Cytokines and inflammation in cartilage degradation. (1993) (199)
Articular cartilage and changes in arthritis: Noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage (2001) (199)
Age‐Related changes in cartilage proteoglycans: Quantitative electron microscopic studies (1994) (196)
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. (1999) (195)
The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. (2002) (186)
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage (2015) (179)
Introduction: disc degeneration: summary. (2004) (167)
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage. (1995) (164)
Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation (2006) (161)
SLRP interaction can protect collagen fibrils from cleavage by collagenases. (2006) (159)
Effects of mechanical loading on intervertebral disc metabolism in vivo. (2006) (157)
In vivo remodeling of intervertebral discs in response to short‐ and long‐term dynamic compression (2009) (157)
Structure, function, aging and turnover of aggrecan in the intervertebral disc. (2014) (154)
Lumican and decorin are differentially expressed in human breast carcinoma (2000) (149)
Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan* (1997) (148)
The Human Lumican Gene (1995) (148)
Are cytokines involved in osteoarthritic pathophysiology? (1991) (146)
Osteogenesis imperfecta--clinical and molecular diversity. (2003) (146)
Bone Morphogenetic Protein-1 Processes Probiglycan* (2000) (142)
Non-proteoglycan forms of biglycan increase with age in human articular cartilage. (1993) (133)
Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples. (1997) (132)
Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage (1996) (132)
The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis. (1977) (129)
The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. (2006) (127)
A biological approach to treating disc degeneration: not for today, but maybe for tomorrow (2002) (125)
Glypican and Biglycan in the Nuclei of Neurons and Glioma Cells: Presence of Functional Nuclear Localization Signals and Dynamic Changes in Glypican During the Cell Cycle (1997) (125)
Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. (2006) (123)
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes (2010) (119)
Age-related changes in fibromodulin and lumican in human intervertebral discs. (1999) (118)
Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. (2001) (116)
Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering. (2005) (115)
Extracellular matrix composition in COPD (2012) (114)
Relationship between genotype and skeletal phenotype in children and adolescents with osteogenesis imperfecta (2009) (113)
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues (2008) (112)
The structure and degradation of aggrecan in human intervertebral disc (2006) (111)
The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis. (1987) (106)
Extraction and characterization of proteoglycan from human meniscus. (1980) (106)
Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ. (1989) (104)
Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. (1993) (103)
Effect of glycosaminoglycan degradation on lung tissue viscoelasticity. (2001) (99)
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site (2006) (98)
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis (2005) (95)
Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in Gαs from patients with fibrous dysplasia of bone (1997) (94)
Osteogenesis imperfecta type V: marked phenotypic variability despite the presence of the IFITM5 c.−14C>T mutation in all patients (2012) (94)
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage. (1993) (94)
Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs. (2006) (91)
Genotype–phenotype correlations in nonlethal osteogenesis imperfecta caused by mutations in the helical domain of collagen type I (2010) (91)
Airway proteoglycans are differentially altered in fatal asthma (2005) (91)
Aggrecan Turnover in Human Intervertebral Disc as Determined by the Racemization of Aspartic Acid* (2006) (90)
Lumican is a major proteoglycan component of the bone matrix. (2002) (90)
Calcification in human intervertebral disc degeneration and scoliosis (2011) (89)
Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage. (1992) (89)
Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans. (1986) (88)
Analysis of Intimal Proteoglycans in Atherosclerosis-prone and Atherosclerosis-resistant Human Arteries by Mass Spectrometry*S (2005) (87)
Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. (2002) (85)
Effect of Oxygen Levels on Proteoglycan Synthesis by Intervertebral Disc Cells (2011) (85)
Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. (1990) (85)
The Structure, Location, and Function of Perlecan, a Prominent Pericellular Proteoglycan of Fetal, Postnatal, and Mature Hyaline Cartilages* (2006) (85)
The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration (2010) (85)
Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. (2014) (85)
Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (1989) (84)
Proteinase inhibitors of bovine nasal cartilage. (1978) (82)
Changes in the expression of decorin and biglycan in human articular cartilage with age and regulation by TGF-beta. (1994) (82)
The characterization of versican and its message in human articular cartilage and intervertebral disc (2002) (81)
Skeletal clinical characteristics of osteogenesis imperfecta caused by haploinsufficiency mutations in COL1A1 (2013) (78)
Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin. (1992) (76)
Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc (2011) (75)
The cleavage of biglycan by aggrecanases. (2006) (75)
Degradation of human proteoglycan aggregate induced by hydrogen peroxide. Protein fragmentation, amino acid modification and hyaluronic acid cleavage. (1989) (75)
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism. (2002) (75)
Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential (2011) (74)
Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan. (1993) (73)
Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism. (2002) (72)
The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan heterogeneity and the pathway of proteolytic degradation. (1977) (72)
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. (2011) (71)
Expression of lumican in human lungs. (1998) (69)
Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage. (1985) (68)
A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc (2003) (66)
Development of a bioreactor for axially loaded intervertebral disc organ culture. (2011) (66)
A vision on the future of articular cartilage repair. (2014) (65)
Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs (2007) (65)
Osteogenesis imperfecta type VII maps to the short arm of chromosome 3. (2002) (64)
Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican. (2008) (64)
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice (2005) (63)
Age-related changes in the structure of proteoglycan link proteins present in normal human articular cartilage. (1983) (62)
Alterations in large and small proteoglycans in bleomycin-induced pulmonary fibrosis in rats. (2000) (62)
Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints (1999) (62)
Changes with age in the structure of fibromodulin in human articular cartilage. (1996) (62)
Lack of circulating pigment epithelium-derived factor is a marker of osteogenesis imperfecta type VI. (2012) (61)
The presence of a cartilage-like proteoglycan in the adult human meniscus. (1981) (60)
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism. (1999) (60)
Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage. (1991) (58)
Presence of pro-forms of decorin and biglycan in human articular cartilage. (1996) (56)
Cortical and trabecular bone density in X-linked hypophosphatemic rickets. (2013) (55)
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M. (2008) (54)
Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. (2015) (53)
Assignment of the human aggrecan gene (AGC1) to 15q26 using fluorescence in situ hybridization analysis. (1993) (53)
Enhanced denaturation of the α1(II) chains of type‐II collagen in normal adult human intervertebral discs compared with femoral articular cartilage (1996) (53)
Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-β1 and interferon-γ (2002) (53)
Alterations in lung mechanics in decorin-deficient mice. (2005) (52)
Best paper NASS 2013: link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs. (2013) (52)
Measurement of glycosaminoglycan release from cartilage explants. (2007) (51)
Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc. (2014) (51)
A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discs (2012) (51)
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage. (2006) (51)
Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. (2012) (50)
Anabolic and catabolic markers of proteoglycan metabolism in osteoarthritis. (1995) (50)
The heterogeneity of link proteins isolated from human articular cartilage proteoglycan aggregates. (1982) (49)
Human cartilaginous endplate degeneration is induced by calcium and the extracellular calcium-sensing receptor in the intervertebral disc. (2016) (49)
Link Protein Has Greater Affinity for Versican than Aggrecan* (2004) (48)
Genetic Rescue of Chondrodysplasia and the Perinatal Lethal Effect of Cartilage Link Protein Deficiency* (2003) (47)
Cranial base abnormalities in osteogenesis imperfecta: Phenotypic and genotypic determinants (2011) (47)
The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. (1996) (47)
Physiological Loading Can Restore the Proteoglycan Content in a Model of Early IVD Degeneration (2014) (46)
The dermatan sulfate proteoglycans of the adult human meniscus (1992) (45)
Short- and long-term outcome of patients with pseudo-vitamin D deficiency rickets treated with calcitriol. (2011) (45)
Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. (2014) (44)
Thirty‐three novel COL1A1 and COL1A2 mutations in patients with osteogenesis imperfecta types I‐IV (2001) (43)
The action of human articular-cartilage metalloproteinase on proteoglycan and link protein. Similarities between products of degradation in situ and in vitro. (1986) (42)
Ageing and the aggregating proteoglycans of human articular cartilage. (1986) (41)
Treatment of cartilage proteoglycan aggregate with hydrogen peroxide. Relationship between observed degradation products and those that occur naturally during aging. (1987) (41)
Expression of cell-surface proteoglycan mRNA by human articular chondrocytes. (1995) (41)
Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in G alpha s from patients with fibrous dysplasia of bone. (1997) (41)
Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. (2008) (40)
The expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B' domains. (1994) (40)
Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs (2013) (39)
Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability. (2015) (39)
The origin of human cartilage proteoglycan link-protein heterogeneity and fragmentation during aging. (1985) (38)
Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging* (2013) (38)
Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. (1994) (37)
Mononuclear cell factors stimulate the concomitant secretion of distinct latent proteoglycan, gelatin and collagen degrading enzymes from human skin fibroblasts and synovial cells. (1983) (37)
Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-α signaling (2005) (37)
Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo (2011) (36)
Biochemical and morphologic studies of cartilage from the adult human sacroiliac joint. (1983) (36)
TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs (2015) (36)
TGF beta 1 and biglycan, decorin, and fibromodulin metabolism in canine cartilage. (2003) (35)
Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration. (2006) (35)
The properties of proteoglycan prepared from human articular cartilage by using associative caesium chloride gradients of high and low starting densities. (1985) (34)
O-Linked oligosaccharides of human articular cartilage proteoglycan. (1982) (33)
Variations in aggrecan structure modulate its susceptibility to aggrecanases. (2003) (33)
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage. (2011) (33)
The Role of Hyaluronan Produced by Has2 Gene Expression in Development of the Spine (2011) (32)
Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency. (1989) (32)
Link protein can retard the degradation of hyaluronan in proteoglycan aggregates. (2006) (31)
Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor. (1986) (31)
The synthesis of dermatan sulphate proteoglycans by fetal and adult human articular cartilage. (1989) (31)
Age-associated changes in cartilage matrix: implications for tissue repair. (2001) (30)
Different Usage of the Glycosaminoglycan Attachment Sites of Biglycan* (2001) (30)
The Glycosaminoglycan Attachment Regions of Human Aggrecan* (2006) (29)
Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor. (2016) (28)
Proteoglycans from normal and degenerate cartilage of the adult human tibial plateau. (1981) (28)
Disc Degeneration: Summary (2004) (28)
Modulation of keratan sulfate synthesis on lumican by the action of cytokines on human articular chondrocytes. (1999) (27)
Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling. (2005) (27)
Analysis of proteoglycan messages in human articular cartilage by a competitive PCR technique. (1997) (27)
Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma. (2002) (26)
Whole-exome sequencing reveals a heterozygous LRP5 mutation in a 6-year-old boy with vertebral compression fractures and low trabecular bone density. (2013) (26)
Comparison of proteoglycans extracted from high and low weight-bearing human articular cartilage, with particular reference to sialic acid content. (1981) (26)
Lumican inhibits collagen deposition in tissue engineered cartilage. (2008) (26)
The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells (2012) (25)
A large family with features of pseudoachondroplasia and multiple epiphyseal dysplasia: exclusion of seven candidate gene loci that encode proteins of the cartilage extracellular matrix (1994) (24)
Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis (2016) (24)
Intervertebral disc changes with angulation, compression and reduced mobility simulating altered mechanical environment in scoliosis (2011) (24)
Variation in Chondroadherin Abundance and Fragmentation in the Human Scoliotic Disc (2009) (24)
The effect of SERPINF1 in-frame mutations in osteogenesis imperfecta type VI. (2015) (22)
Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression. (2004) (22)
Osteogenesis imperfecta type III with intracranial hemorrhage and brachydactyly associated with mutations in exon 49 of COL1A2 (2009) (22)
The electrophoretic heterogeneity of bovine nasal cartilage proteoglycans. (1976) (22)
The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages. (1987) (22)
Targeted Sequencing of a Pediatric Metabolic Bone Gene Panel Using a Desktop Semiconductor Next-Generation Sequencer (2014) (22)
Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism (2013) (22)
Proteinase inhibitors of human articular cartilage. (1983) (21)
A Nucleotomy Model with Intact Annulus Fibrosus to Test Intervertebral Disc Regeneration Strategies. (2015) (21)
A comparative study of the glycosaminoglycan-peptides obtained after degradation of cartilage proteoglycan by different proteinases, and their use in the characterization of different proteoglycans. (1978) (21)
Proteoglycans of the Intervertebral Disc (2014) (20)
The response of mineralizing culture systems to microtextured and polished titanium surfaces (2008) (20)
A co‐occurrence of osteogenesis imperfecta type VI and cystinosis (2012) (20)
Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development (2011) (20)
Diarylheptanoids; The problems of the biosynthesis (1971) (20)
Severe osteogenesis imperfecta caused by a small in‐frame deletion in CRTAP (2011) (19)
The Structure and Abundance of Cartilage Proteoglycans during Early Development of the Human Fetus (1987) (19)
The role of link protein in mediating the interaction between hyaluronic acid and newly secreted proteoglycan subunits from adult human articular cartilage. (1985) (19)
Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (1999) (19)
Rabbit antibodies to degraded and intact glycosaminoglycans which are naturally occurring and present in arthritic rabbits. (1985) (18)
Changes in leucine-rich repeat proteoglycans during maturation of the bovine growth plate. (2001) (18)
Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model. (2014) (17)
Osteogenesis imperfecta: comparison of molecular defects with bone histological changes. (1994) (17)
Studies on the interaction of newly secreted proteoglycan subunits with hyaluronate in human articular cartilage. (1990) (17)
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage. (2008) (17)
Characterization and expression of murine PRELP. (2001) (17)
ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration (2017) (16)
Production of antibodies against degradative neoepitopes in aggrecan. (2004) (16)
The structure and chromosome location of the human chondroadherin gene (CHAD). (1997) (16)
Proteolytic degradation in human articular cartilage: its relationship to stromelysin. (1993) (15)
Link protein shows species variation in its susceptibility to proteolysis (1992) (15)
Characterization of opticin digestion by proteases involved in osteoarthritis development. (2014) (15)
The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism. (2014) (14)
Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity (2014) (12)
A matrix protein of Mr 55,000 that accumulates in human articular cartilage with age. (1990) (12)
The use of caesium sulphate density gradient centrifugation to analyse proteoglycans from human articular cartilages of different ages. (1983) (12)
The consequence of PRELP overexpression on skin. (2007) (12)
Analysis of aggrecan catabolism by immunoblotting and immunohistochemistry. (2012) (12)
A comparative study of the proteoglycan of growth cartilage of normal and rachitic chicks. (1978) (12)
Development of a whole disc organ culture system to study human intervertebral disc (2010) (12)
The interactions of 'non-aggregating' proteoglycans. (1995) (11)
Identification of type I collagen gene (COL1A2) mutations in nonlethal osteogenesis imperfecta. (1993) (11)
Analysis of the Human Lumican Gene Promoter* (2000) (11)
Short Link N promotes disc repair in a rabbit model of disc degeneration (2018) (11)
The Effects of Chlorhexidine Graft Decontamination on Tendon Graft Collagen and Cell Viability (2012) (11)
Oto-palato-digital syndrome, type II: report of three cases with further delineation of the chondro-osseous morphology. (2000) (10)
Age-related changes in the antigenicity of human articular cartilage proteoglycans. (1982) (10)
Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. (1998) (10)
Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1 (2014) (10)
Normal bone density and fat mass in heterozygous SERPINF1 mutation carriers. (2014) (10)
Mechanisms of proteoglycan degradation in human articular cartilage. (1991) (10)
Factors influencing proteoglycan size in rachitic-chick growth cartilage. (1980) (9)
Catabolism of Proteoglycans (2000) (9)
Isolation, characterization and immunohistochemical localization of a dermatan sulfate-containing proteoglycan from bovine fetal epiphyseal cartilage. (1982) (9)
The inability to prepare high-buoyant-density proteoglycan aggregates from extracts of normal adult human articular cartilage. (1984) (9)
The use of biochemical markers of bone and cartilage metabolism to monitor osteoarthritis--dreams and reality. (2003) (8)
A comparison of proteoglycan from chick cartilage of different types and a study of the effect of vitamin D on proteoglycan structure. (1986) (8)
Effect of vitamin D and plasma calcium upon proteoglycan size in chick growth cartilage. (1979) (7)
Structural changes in the proteoglycans of human articular cartilage during aging. (1987) (7)
The effects of vitamin D deficiency on proteoglycan and hyaluronate constituents of chick bone. (1993) (7)
Metabolic Effects of Angulation, Compression, and Reduced Mobility on Annulus Fibrosis in a Model of Altered Mechanical Environment in Scoliosis. (2013) (7)
Resolution of cartilage proteoglycan and its proteolytic degradation products by high-performance liquid chromatography using a gel filtration system. (1985) (6)
Absence of the dermatan sulfate chain of decorin does not affect mouse development (2017) (6)
Short link N acts as a disease modifying osteoarthritis drug. (2019) (5)
Variation in the effects of mononuclear cell products from different individuals on metalloproteinase secretion from human articular cartilage. (1989) (5)
Physicochemical properties of cartilage proteoglycans extracted by lanthanum chloride. (1978) (4)
Sulphation heterogeneity in the trisaccharide ( GalNAcS β 1 , 4 GlcA β 1 , 3 GalNAcS ) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate (1999) (4)
The degradation of proteoglycan by leucocyte elastase. (1977) (4)
Activation of latent collagenase by serum proteinases that interact with immobilized immunoglobulin G (2004) (4)
Identification of type I collagen gene polymorphisms: tolerance of sequence variation at an alpha 2(I) helix Y position. (1994) (4)
TNF alpha Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs (4)
Age-related changes in the proteoglycan subunits isolated from human articular cartilage☆ (1981) (3)
METABOLIC EFFECTS OF ANGULATION, COMPRESSION AND REDUCED MOBILITY ON ANNULUS FIBROSIS IN A MODEL OF ALTERED MECHANICAL ENVIRONMENT IN SCOLIOSIS. (2013) (3)
Age variation in histidinoalanine cross-links in proteoglycan subunits from human articular cartilage. (1984) (3)
Aggregation of Cartilage Proteoglycans Extracted with Lanthanum Chloride (1974) (2)
Insect cell conditioned medium contains an endoglycosidase able to liberate chondroitin sulfate chains from aggrecan. (2005) (2)
Changes in cartilage proteoglycan structure during ageing: origin and effects--a review. (1986) (2)
Immunodetection and characterization of the degradation of cartilage proteoglycans in vitro and in vivo. (1987) (2)
Correction: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site (2013) (2)
Evaluation of Tissue Repair Using MRI Imaging of Human Intervertebral Discs Cultured in a Bioreactor (2016) (1)
Excess Biglycan Interferes with TGF– Signaling Required for Eyelid Morphogenesis (2004) (1)
Articular Cartilage and Intervertebral Disc Degeneration in Ovariectomized Mice (2002) (1)
The role of mononuclear cell products as modulators of cartilage degradation. (1987) (1)
The Structure, Degradation and Lifespan of Aggrecan in the Human Intervertebral Disc (2005) (1)
Helix formation. Its involvement in the formation of gel structures. (1975) (1)
Degradation of the proteoglycans of human articular cartilage by reactive oxygen metabolites. (1988) (1)
Chapter 6 – Proteoglycans of the Intervertebral Disk (2008) (1)
Proteins and hyaluronic acid associated with proteoglycans extracted from bovine nasal cartilage with low-ionic-strength salt solution. (1975) (1)
The Role of HA and Has2 in the Development and Function of the Skeleton (2013) (1)
Structural changes during development in bovine fetal epiphyseal cartilage. (1981) (1)
PAPER 109: EFFECT OF ESTROGEN DEFICIENCY ON ARTICULAR CARTILAGE AND INTERVERTEBRAL DISC OF MICE (2010) (1)
Potential of Link-N to Stimulate Repair in the Degenerated Human Intervertebral Discs (2013) (0)
Targeted Sequencing of a Pediatric Metabolic Bone Gene Panel Using a Desktop Semiconductor Next-Generation Sequencer (2014) (0)
Methodsfor MeasuringPlasmaHemoglobin in MicromolarConcentration Compared (1992) (0)
EFFECT OF OXYGEN LEVELS ON PROTEOGLYCAN SYNTHESIS BY IVD CELLS (2008) (0)
LONG TERM DYNAMIC COMPRESSION OF THE INTERVERTEBRAL DISC CAUSES REMODELING IN VIVO (2008) (0)
PAPER 107: INTERVERTEBRAL DISC AND ARTICULAR CARTILAGE DEGENERATION IN MICE LACKING EARLY GROWTH RESPONSE PROTEIN-1 (EGR-1) (2010) (0)
The role of Has2 on long bone development (2008) (0)
The Role of Cancer Therapy Agents in Intervertebral Disc Degeneration (2012) (0)
Poster 227 Chronic Exposure to Tobacco Smoke Damages Intervertebral Disc Matrix in an Animal Model (2012) (0)
451 UNIQUE FEATURES OF OSM AND ADAMTS5 ON AGGRECAN DEGRADATION (2009) (0)
PROTEOGLYCAN POPULATIONS IN HUMAN INTERVERTEBRAL DISCS – SMALL IS BEAUTIFUL? (2018) (0)
OSTEOARTHRITIS and CARTILAGE Changes with age in the structure of fibromodulin in human articular cartilage (1996) (0)
LINK between Degeneration and Regeneration of Human Intervertebral Discs (2014) (0)
Correlation of in-vivo fragmentation of fibromodulin with that generated in-vitro by MMP-13 and ADAMTS-4 but not ADAMTS-5 (2009) (0)
Hiearchical catabolism of collagen associated proteoglycans in in vitro models of progressive articular cartilage degradation (2002) (0)
DISTINCTION BETWEEN NORMAL NUCLEUS PULPOSUS AND HYALINE CARTILAGE PHENOTYPES FOR TISSUE ENGINEERING OF INTERVERTEBRAL DISC (2008) (0)
LONG TERM HUMAN INTERVERTEBRAL DISC ORGAN CULTURE: FROM IMPOSSIBLE TO I'M POSSIBLE (2012) (0)
Excess Biglycan Blocks TGF Signaling for Eyelid Morphogenesis during Development of Kera-Bgn Transgenic Mice (2003) (0)
Acknowledgement to Referees (2009) (0)
Lumican And Biglycan Expression In Lungs Of COPD Patients (2010) (0)
Chondroadherin Fragmentation Mediated By HTRA 1 Can Serve As A Biomarker For Early Stage Disc Degeneration (2014) (0)
Mononuclear cell factor modulates the concomitant release of proteoglycan and latent proteinase by human articular cartilage in organ culture. (1986) (0)
Maintenance of cell viability in axially loaded intervertebral disc organ culture (2011) (0)
56 – EFFECT OF LINK-N ON DISC REPAIR IN A RABBIT MODEL OF INTERVERTEBRAL DISC DEGENERATION (2011) (0)
The structure and expression of the human PRELP gene (1996) (0)
Chromosomal localization of the human fibromodulin gene (1994) (0)
P35. Changes in tenascin distribution are associated with rachitic lesions: localisation studies in vitamin D-deficient chick and hyp mouse bone (1996) (0)
201 DEGRADATION OF OPTICIN, A MEMBER OF THE SMALL LEUCINE-RICH REPEAT PROTEOGLYCANS FAMILY, BY METALLOPROTEASES AND ADAMTS INVOLVED IN OSTEOARTHRITIS (2008) (0)
178 AN ORGAN CULTURE MODEL TO STUDY BIOLOGICAL REPAIR OF THE DEGENERATE INTERVERTEBRAL DISC (2009) (0)
WITHDRAWN: PUBLISHED IN ERROR BY PUBLISHER: Lumican core protein increases melanoma cell adhesion through a beta 1-type integrin receptor. (2007) (0)
Histology and biochemical studies of epiphyseal cartilage in a sporadic case of campomelic syndrome (1984) (0)
British society for matrix biology autumn meeting (2005) (0)

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