Pierre-marie Laduron
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Pierre-marie Laduron's Degrees
- PhD Pharmaceutical Sciences Université libre de Bruxelles
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(Suggest an Edit or Addition)Pierre-marie Laduron's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. (1982) (1011)
- Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. (1981) (836)
- Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding. (1978) (528)
- Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. (1985) (449)
- Pharmacological properties of a potent and selective nonpeptide substance P antagonist. (1991) (407)
- Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. (1979) (400)
- Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines. (1999) (178)
- Spiperone: a ligand of choice for neuroleptic receptors. 2. Regional distribution and in vivo displacement of neuroleptic drugs. (1978) (167)
- Axonal transport of opiate receptors in capsaicin-sensitive neurones (1984) (159)
- Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia (1992) (149)
- Characterization and regional distribution of serotonin S2-receptors in human brain (1983) (138)
- Criteria for receptor sites in binding studies. (1984) (129)
- Two populations of neurotensin binding sites in murine brain: discrimination by the antihistamine levocabastine reveals markedly different radioautographic distribution. (1987) (126)
- Tissue fractionation and catecholamines. II. Intracellular distribution patterns of tyrosine hydroxylase, dopa decarboxylase, dopamine-beta-hydroxylase, phenylethanolamine N-methyltransferase and monoamine oxidase in adrenal medulla. (1968) (101)
- Specific in vivo binding of neuroleptic drugs in rat brain. (1977) (98)
- Transport of noradrenaline and dopamine-β-hydroxylase in sympathetic nerves (1968) (93)
- In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole. (1982) (92)
- Axoplasmic transport of muscarinic receptors (1980) (90)
- In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain. (1982) (86)
- Differential distribution of opiate and neuroleptic receptors and dopamine-sensitive adenylate cyclase in rat brain. (1977) (85)
- Spiperone: a ligand of choice for neuroleptic receptors. 3. Subcellular distribution of neuroleptic drugs and their receptors in various rat brain areas. (1978) (82)
- Inhibition of dopamine receptors in the stomach: an explanation of the gastrokinetic properties of domperidone. (1978) (80)
- N-methylation of dopamine to epinine in brain tissue using N-methyltetrahydrofolic acid as the methyl donor. (1972) (76)
- Differentiation of opiate and neuroleptic receptor binding in rat brain. (1977) (75)
- STEREOSPECIFIC IN VlTRO BINDING OF [3H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS (1979) (71)
- Retrograde axonal transport of neurotensin in the dopaminergic nigrostriatal pathway in the rat (1990) (66)
- Different Subcellular Localization of Neurotensin‐Receptor and Neurotensin‐Acceptor Sites in the Rat Brain Dopaminergic System (1988) (64)
- Solubilisation of high-affinity dopamine receptors (1979) (63)
- Axoplasmic transport and possible recycling of opiate receptors labelled with 3H-lofentanil. (1982) (62)
- Domperidone, a novel and safe gastrokinetic anti-nauseant for the treatment of dyspepsia and vomiting. (1978) (61)
- Different postnatal ontogeny of two [3H]neurotensin binding sites in rat brain (1987) (61)
- Solubilization of 3H-spiperone binding sites from rat brain. (1978) (59)
- Short‐term disappearance of muscarinic cell surface receptors in carbachol‐induced desensitization (1983) (59)
- Symposium on: receptors of dopamine antagonists: new biochemical approaches. July 6-8, 1978, Beerse, Belgium. (1978) (59)
- Tissue fractionation and catecholamines. I. Latency and activation properties of dopamine-beta-hydroxylase in adrenal medulla. (1968) (58)
- Axonal transport of the voltage-dependent Na+ channel protein identified by its tetrodotoxin binding site in rat sciatic nerves (1985) (55)
- Regional and Cortical Laminar Distributions of Serotonin S2, Benzodiazepine, Muscarinic, and Dopamine D2 Receptors in Human Brain (1984) (53)
- Axonal transport of receptors: coexistence with neurotransmitter and recycling. (1984) (52)
- Tissue fractionation in neurobiochemistry: an analytical tool or a source of artifacts. (1977) (51)
- Axonal transport of neuroreceptors: Possible involvement in long-term memory (1987) (50)
- Polyclonal antibodies against the rat NK1 receptor: characterization and localization in the spinal cord. (1992) (50)
- Rapid agonist-induced decrease of neurotensin receptors from the cell surface in rat cultured neurons. (1991) (48)
- [3H]Desipramine and [3H]imipramine binding are not associated with noradrenaline and serotonin uptake in the brain. (1982) (48)
- Effects of some derivatives of 2-aminotetralin on dopamine-sensitive adenylate cyclase and on the binding of (3H)haloperidol to neuroleptic receptors in the rat striatum. (1978) (45)
- Are 5-HT2 antagonists endowed with anxiolytic properties in rodents? (1991) (45)
- [3H]Batrachotoxinin A 20-alpha-benzoate binding to sodium channels in rat brain: characterization and pharmacological significance. (1986) (45)
- Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain (1986) (44)
- Solubilization of brain muscarinic, dopaminergic and serotonergic receptors: a critical analysis. (1982) (43)
- Neurotensin increases tyrosine hydroxylase messenger RNA-positive neurons in substantia nigra after retrograde axonal transport (1992) (43)
- Differential effects of the isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dog. (1977) (42)
- Internalization and intracellular mobilization of neurotensin in neuronal cells. (1994) (41)
- Characterization of digitonin‐solubilized muscarinic receptor from rat brain (1978) (41)
- N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor. (1974) (39)
- Characterization of an enzyme yielding formaldehyde from‐5‐methyltetrahydrofolic acid (1974) (39)
- From receptor internalization to nuclear translocation. New targets for long-term pharmacology. (1994) (37)
- Evidence for a localization of dopamine‐β‐hydroxylase within the chromaffin granules (1975) (36)
- Solubilization of muscarinic acetylcholine receptors from mammalian brain: an analytical approach. (1981) (36)
- Differentiation of solubilized dopamine receptors from spirodecanone binding sites in rat striatum (1980) (35)
- Riluzole, a glutamate antagonist, enhances slow wave and REM sleep in rats (1988) (35)
- Dopamine receptor: from an in vivo concept towards a molecular characterization (1980) (34)
- Light and electron microscopic localization of retrogradely transported neurotensin in rat nigrostriatal dopaminergic neurons (1992) (34)
- Tissue fractionation and catecholamines. 3. Intracellular distribution of endogenous inhibitors of dopamine- -hydroxylase in adrenal medulla. (1968) (33)
- Evidence for an Extragranular Localization of Tyrosine Hydroxylase (1968) (33)
- Characterization of specific in vivo binding of neuroleptic drugs in rat brain. (1978) (33)
- Retrograde axonal transport of receptor-bound opiate in the vagus and delayed accumulation in the nodose ganglion (1985) (32)
- Scope and limitation in dopamine β-hydroxylase measurement (1975) (32)
- Characterization of solubilized dopamine receptors from dog striatum (1979) (31)
- Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. (1991) (31)
- New indole derivatives as potent and selective serotonin uptake inhibitors. (1993) (30)
- Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas. (1979) (30)
- Subcellular localization of dopamine-sensitive adenylate cyclase in rat brain striatum. (1976) (30)
- Retrograde axonal transport of neurotensin in rat nigrostriatal dopaminergic neurons. Modulation during ageing and possible physiological role. (1994) (29)
- Presynaptic heteroreceptors in regulation of neuronal transmission. (1985) (29)
- Identification of Intact Neurotensin in the Substantia Nigra After Its Retrograde Axonal Transport in Dopaminergic Neurons (1991) (28)
- Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA. (1975) (28)
- A rapid assay and partial purification of dopa decarboxylase. (1968) (28)
- Limiting factors in the antagonism of neuroleptics on dopamine‐sensitive adenylate cyclase (1976) (28)
- Axonal transport of Na+,K+-ATPase identified as a ouabain binding site in rat sciatic nerve (1986) (27)
- Pharmacology and Biochemistry of Haloperidol (1976) (26)
- Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation. (1975) (26)
- Axonal Transport of Receptors A Major Criterion for Presynaptic Localization (1990) (25)
- Characterization of solubilized serotonin (S2) receptors in rat brain. (1982) (25)
- Identification of alkaloids; the condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid. (1975) (24)
- Stereospecificity in binding studies. A useful criterion though insufficient to prove the presence of receptors. (1988) (24)
- RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats. (1992) (24)
- Impaired axonal transport of opiate and muscarinic receptors in streptozocin-diabetic rats (1986) (23)
- Functional consequences of retrograde axonal transport of receptor-bound neurotensin. (1995) (23)
- Agonist-mediated conformational changes of muscarinic receptors in rat brain. (1982) (22)
- More binding, more fancy (1983) (22)
- Genomic pharmacology: more intracellular sites for drug action. (1992) (21)
- Tissue fractionation in rat brain, kidney and liver. I. Intracellular localization of a 5-methyltetrahydrofolic acid requiring enzyme. (1975) (21)
- Postnatal ontogeny of the rat brain neurotensin receptor mRNA (1993) (21)
- Solubilization of serotonin receptors from rat frontal Cortex. (1980) (21)
- IL-1β-like Freund's adjuvant enhances axonal transport of opiate receptors in sensory neurons (1994) (19)
- Axonal transport of muscarinic receptors in vesicles containing noradrenaline and dopamine‐β‐hydroxylase (1984) (17)
- N-Methylation of dopamine to epinine in adrenal medulla: a new model for the biosynthesis of adrenaline. (1972) (16)
- Differential regulation of dopamine-D2 and serotonin-S2 receptors by chronic treatment with the serotonin-S2 antagonists, ritanserin, and setoperone. (1987) (16)
- Pierre M. Laduron replies (1984) (15)
- Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative. (1994) (15)
- Specific effect of haloperidol on dopamine turnover in the frontal cortex (2004) (15)
- Riluzole antagonizes the anxiogenic properties of the β-carboline FG 7142 in rats (2004) (14)
- Antinociceptive properties and inhibition of neurogenic inflammation with potent SP antagonists belonging to perhydroisoindolones (1992) (14)
- NEW CONCEPTS ON THE N-METHYLATION REACTIONS OF BIOGENIC AMINES IN ADRENAL MEDULLA AND BRAIN (1973) (13)
- [3H]RP 62203, a ligand of choice to label in vivo brain 5-HT2 receptors. (1992) (13)
- Lack of direct evidence for adrenergic and dopaminergic autoreceptors (1984) (13)
- Opiate receptors in brain labelled in vivo with [3H]lofentanil (1985) (12)
- Towards Genomic Pharmacology: From Membranal to Nuclear Receptors (1992) (12)
- Tissue fractionation and catecholamines —IV. Adenosine triphosphatase in chromaffin granules: A distribution artefact (1976) (11)
- [RP 67580, a potent and selective substance P non-peptide antagonist]. (1992) (11)
- Benzodiazepine receptors in normal human brain, in Parkinson's disease and in progressive supranuclear palsy (1988) (11)
- Interaction of the substance P receptor antagonist RP 67580 with the rat brain NK1 receptor expressed in transfected CHO cells. (1993) (11)
- Receptor binding properties in vitro and in vivo of some long-acting opiates. (1978) (10)
- TPP+ accumulation in rat brain synaptosomes as a probe for Na+ channels. (1986) (10)
- Muscarinic receptor: multiple sites or unitary concept? (1981) (9)
- Dopamine Receptors and Neuroleptic Drugs (1989) (9)
- Brain Dopamine Receptor: Multiple Binding Sites or Physiological Receptor Site (1982) (9)
- Storage of labeled noradrenaline in lysosomes (1966) (9)
- N-methylation of indolealkylamines in the brain with a new methyl donor. (1974) (9)
- Neuroprotective effects of colchicine in the gerbil model of cerebral ischaemia (1994) (9)
- Solubilization of serotonin S2-receptors from human brain. (1984) (9)
- Preparation and characterization of antisera and monoclonal antibodies to haloperdol (1985) (9)
- Retrograde axonal transport of neurotensin in the rat brain. (1989) (9)
- A NEW HYPOTHESIS ON THE ORIGIN OF SCHIZOPHRENIA (1974) (8)
- RP 62203, a novel naphtosultam derivative with potent and selective 5HT2 antagonist properties: I. Binding and second messenger studies (1990) (8)
- 71 – DOMPERIDONE, A NOVEL GASTROKINETIC AND ANTI-NAUSEANT DRUG, INTERACTS SELECTIVELY WITH DOPAMINE RECEPTORS (1978) (7)
- DIFFERENTIAL ACCUMULATION OF ENZYMES IN CONSTRICTED NERVES ACCORDING TO THEIR SUBCELLULAR LOCALIZATION (1974) (7)
- Discrimination of narcotic drugs on 3H-fentanyl receptor binding. (1976) (7)
- Rp 60180, a new phenothiazine with high affinity for opiate kappa binding sites in animal and human brain (1990) (7)
- Neurotransmitter receptors, part 2, biogenic amines: edited by H. I. Yamamura and S. J. Enna, Chapman and Hall, 1981. £20 (xi + 273 pages) ISBN 0 412 23130 1 (1982) (7)
- Pharmacology and biochemistry of bromperidol. (1978) (6)
- Differential accumulation of various enzymes in constricted sciatic nerves. (1970) (6)
- Symposium on: receptors of dopamine antagonists: new biochemical approaches. July 6--8, 1978, Beerse, Belgium. (1978) (6)
- In vivo determination of the profile of benzodiazepine ligands by comparing the inhibition of 3H-Ro 15-1788 binding to the modulation of cGMP levels in mouse cerebellum. (1988) (6)
- Axonal transport of the synaptic vesicle monoamine carrier identified by [3H]dihydrotetrabenazine binding in rat sciatic nerve (1987) (6)
- Ethanol and opiate decrease the axonal transport of substance-P like immunoreactive material in rat vagus-nerves (1990) (6)
- In vivo formation of epinine in adrenal medulla (1974) (6)
- Studies in organic mass spectrometry. XV. Mass fragmentographic identification of epinine in adrenal medulla and as a product of an in vitro enzymic methylation. (1974) (5)
- Scope and limitation in dopamine beta-hydroxylase measurement. (1975) (5)
- Axonal flow of dopamine-beta-hydroxylase containing granules in splenic nerves. (1968) (5)
- Reduction of the amount of neurotensin retrogradely transported in dopaminergic neurons of senescent rats (1991) (5)
- Effects of ketoprofen in adjuvant-Induced arthritis measured in a new telemetric model test (1990) (5)
- Subcellular distribution of receptor sites in human brain: Differentiation between heavy and light structures of high and low density (1995) (5)
- A serotonergic component of neuroleptic receptors. (1977) (5)
- Enhanced axonal transport of receptor-bound opiate in ethanol-treated rats (1987) (5)
- Antinociceptive properties and inhibition of neurogenic inflammation with potent SP antagonists belonging to perhydroisoindolones (1992) (4)
- Evidence for, and localization of, a unitary dopamine receptor composed of cooperatively linked subunit binding sites in rat striatum. (1979) (4)
- Autoradiographic Localization of Retrogradely Transported Neurotensin in Nigrostriatal Neurons (1992) (4)
- RP 62203, a naphtosultam derivative with potent and selective 5-HT2 antagonist properties: II behavioral profile (1990) (4)
- RP 62203, a naphtosultam derivative with potent and selective 5-HT2 antagonist properties III. Autoradiographic studies (1990) (4)
- Uptake, subcellular distribution and biotransformation of 3H-labelled astemizole in cultured rat hepatocytes. (1987) (4)
- N-methylation of dopamine to epinine in adrenal medulla and brain: A new concept for the biosynthesis of adrenaline and possible implication in schizophrenia (1973) (4)
- Ontogenetic development of a 5-methyltetrahydrofolate requiring enzyme in rats and mice (2004) (3)
- RP 62203, a 5HT2 antagonist, enhances slow wave sleep in rats (1990) (3)
- Solubilized opiate receptors labelled with 3H-lofentanil. (1982) (3)
- Pharmacology of New Sleep-Improving Drugs (1990) (3)
- Subcellular distribution of catecholamines in dog spleen. (1966) (2)
- Axonal flow of muscarinic receptors. (1980) (2)
- A possible role of lysosomal accumulation in constricted sciatic nerves. (1970) (2)
- A new hypothesis on the origin of schizophrenia. (1974) (2)
- A new metabolic pathway in the one-carbon transfer reaction. (1973) (2)
- SPECIFICITY CRITERIA FOR RECEPTOR SITES IN BINDING STUDIES (1984) (2)
- RECEPTOR REGULATION: AXONAL TRANSPORT, INTERNALIZATION AND RECYCLING (1984) (2)
- Presynaptic receptors: more hetero than auto. (1998) (2)
- Specificity of enzyme and methyl donor for methylation reactions. (1973) (2)
- Effect of ATP upon dopamine-β-hydroxylase (1975) (2)
- FURTHER CHARACTERIZATION OF TWO 3H-NEUROTENSIN BINDING SITES IN RAT BRAIN (1987) (2)
- Axonal transport of receptors: characterization, role in receptor regulation and possible involvement in learning. (1987) (2)
- Effects of RP 60180, a kappa-receptor agonist, on dopamine metabolism and utilization in rat and guinea-pig brain (1990) (1)
- HIGH AFFINITY ACCEPTOR SITES IN GUINEA PIG BRAIN FOR [3H]52770 RP, A PAF ANTAGONIST (1989) (1)
- [Haloperidol, a new profile?]. (1978) (1)
- RECEPTOR BINDING TECHNIQUES FOR STUDYING THE SELECTIVITY AND SITE OF ACTION OF PSYCHOTROPIC DRUGS (1984) (1)
- Impact of Janssen drugs for the identification of brain receptors (1986) (1)
- Preparation and characterization of antisera and monoclonal antibodies to haloperidol. (1985) (1)
- Down-regulation of 3H-lofentanil binding to opiate receptors in different cultured neuronal cells (2004) (1)
- Chapter 7 – SOLUBILIZATION OF THE DOPAMINE RECEPTOR (1984) (1)
- Transport of noradrenaline and dopamine-beta-hydroxylase in sympathetic nerves. (1968) (1)
- [Biosynthesis of catecholamines: new concepts]. (1974) (1)
- 831 – PRINCIPLES OF TISSUE FRACTIONATION IN SUBCELLULAR DISTRIBUTION OF DRUG (1978) (1)
- 1477 – ADENYL CYCLASE: A POSSIBLE TARGET FOR MORPHINE-LIKE COMPOUNDS AND NEUROLEPTICS (1977) (1)
- Effect of gamma-butyrolactone on the retrograde axonal transport of neurotensin in dopaminergic neurones. (1990) (1)
- Enhanced Axonal-transport of Receptor-bound Opiate After Long-term Exposure To Ethanol (1988) (1)
- Dopamine receptor: from synaptic membranes to solubilization. (1980) (0)
- Endogenous ligands for CNS drug receptors? (1978) (0)
- Use of 2-amino-6-trifluoromethoxy-benzothiazol for the preparation of a medicament (1988) (0)
- Decay of gerbil electrocorticogramme following reversible bilateral carotid occlusion (1990) (0)
- Abstracts of papers (2006) (0)
- Intracellular localization of catecholamine biosynthesis in adrenal medulla. (1967) (0)
- Physico-chemical properties of catecholamine granules and mitochondria from adrenal medulla. (1968) (0)
- Isolation of receptor-bearing membranes from rat brain microsomes after digitonin treatment [proceedings]. (1979) (0)
- Correlation between biochemical and pharmacological latency for the catecholamines containing granules. (1968) (0)
- Activity in QSAR: From A major to A minor (1993) (0)
- REGULATION OF μ-OPIATE RECEPTORS IN CULTURED NEURONS (1987) (0)
- Effect of ATP upon dopamine-beta-hydroxylase. (1975) (0)
- Chapter 24 Genomic pharmacology: From receptor internalization to nuclear translocation of third messengers (1997) (0)
- High-affinity dopamine receptors solubilized from dog striatum [proceedings]. (1979) (0)
- Intracellular distribution of endogenous inhibitors of dopamine-beta-hydroxylase. (1968) (0)
- Enzymatic degradation and disposition of 3H norepinephrine in dogs' cutaneous veins (1975) (0)
- Latency and intracellular distribution of dopamine-beta-hydroxylase in bovine adrenal medulla. (1967) (0)
- Kinetic investigation of [3H] spiperone-binding sites in rat frontal cortex [proceedings]. (1978) (0)
- Axonal flow of enzymes involved in the biosynthesis of catecholamines. (1970) (0)
- Electrocorticograpnic profile and discriminative stimulus properties of RP 60180, a new kappa agonist (1990) (0)
- N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. (1972) (0)
- NEUROPROTECTIVE ACTIONS OF RILUZOLE IN TWO MODELS OF CEREBRAL ISCHAEMIA (1992) (0)
- Use of certain kind of compound for treating sleep disorder and depression (1988) (0)
- Application of 2-amino-6-trifluoromethoxy benzothiazole to obtain a medicament for the treatment of sleep disorders and depression (1987) (0)
- [Axonal transport of neuroreceptors]. (1987) (0)
- From monotherapy to multiple drug therapy through long-term pharmacology (1997) (0)
- Neuroprotection against ischaemia and Improvement of sleep quality with rlluzole a novel antiglutamate. (1989) (0)
- Receptors in classical pharmacology and cell biology. A report of a symposium held on the occasion of the 25th anniversary of the first publication of Biochemical Pharmacology. (1983) (0)
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