Philip Reed Larsen

Philip Reed Larsen's AcademicInfluence.com Rankings

Philip Reed Larsen

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#5403

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#7875

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Physiology

#122

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#272

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Biochemistry

#632

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#728

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Biology

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Philip Reed Larsen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. (2002) (1700)
Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. (2005) (994)
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme (1991) (822)
Long‐term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation (2007) (691)
Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. (2006) (644)
Maternal and fetal thyroid function. (1994) (643)
Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region (1991) (612)
Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. (1981) (541)
Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism (2009) (530)
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. (2000) (487)
Identification of a thyroid hormone receptor that is pituitary-specific. (1989) (467)
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. (2001) (451)
Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. (2006) (450)
Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. (2004) (450)
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing (1989) (418)
Usefulness of Ultrasonography in the Management of Nodular Thyroid Disease (2000) (397)
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. (1993) (394)
Screening for congenital hypothyroidism: results of screening one million North American infants. (1979) (378)
Hypothyroidism after Sunitinib Treatment for Patients with Gastrointestinal Stromal Tumors (2006) (375)
Adrenergic activation of triiodothyronine production in brown adipose tissue (1983) (374)
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. (1982) (342)
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. (2005) (325)
Levothyroxine Therapy in Patients with Thyroid Disease (1993) (324)
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. (1997) (300)
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. (1996) (275)
Natural History of Benign Solid and Cystic Thyroid Nodules (2003) (265)
Thyroid hormone regulation of gene expression. (1991) (247)
Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. (2008) (242)
Thyroid hormones and skeletal muscle—new insights and potential implications (2014) (239)
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. (1982) (232)
High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease. (2002) (222)
Thyroid nodule size and prediction of cancer. (2013) (221)
Thyroxine 5'-deiodinase activity in brown adipose tissue. (1983) (211)
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. (2005) (210)
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. (1980) (206)
Direct immunoassay of triiodothyronine in human serum. (1972) (204)
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. (1996) (202)
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. (1985) (202)
Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute in (1978) (200)
Cerebral cortex responds rapidly to thyroid hormones. (1981) (199)
Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. (1983) (199)
A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. (2013) (199)
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. (1988) (196)
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. (1989) (196)
Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. (2003) (192)
Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. (1982) (192)
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. (1995) (191)
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. (1978) (186)
Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. (1999) (186)
CHAPTER 11 – Thyroid Physiology and Diagnostic Evaluation of Patients with Thyroid Disorders (2011) (182)
Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. (2004) (168)
Nutritional and hormonal regulation of thyroid hormone deiodinases. (1995) (167)
Prevalence of abnormal thyroid function test results in patients with acute medical illnesses. (1982) (164)
Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. (1972) (163)
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes (2007) (162)
Genetic and biological subgroups of low-stage follicular thyroid cancer. (2003) (159)
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine (1977) (158)
Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. (1979) (151)
Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. (1982) (147)
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. (1987) (145)
Immunoassay of thyroxine in unextracted human serum. (1973) (144)
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. (1989) (143)
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. (2000) (142)
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. (1991) (142)
Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease. (1981) (141)
Triiodothyronine: review of recent studies of its physiology and pathophysiology in man. (1972) (141)
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. (2010) (141)
Relation of severity of maternal hypothyroidism to cognitive development of offspring (2001) (140)
Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. (1973) (140)
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene (1995) (139)
Thyroid dysfunction from antineoplastic agents. (2011) (134)
Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. (1974) (133)
The Influence of Patient Age on Thyroid Nodule Formation, Multinodularity, and Thyroid Cancer Risk. (2015) (132)
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. (1989) (132)
Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis. (1994) (131)
The Iodothyronine Selenodeiodinases Are Thioredoxin-fold Family Proteins Containing a Glycoside Hydrolase Clan GH-A-like Structure* (2003) (130)
Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. (2005) (128)
Cellular and structural biology of the deiodinases. (2005) (128)
Effect of acute exposure to cold on the activity of the hypothalamic-pituitary-thyroid system. (1975) (126)
Rapid thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat cerebral cortex and cerebellum. (1980) (125)
Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism. (1982) (124)
Human Type 3 Iodothyronine Selenodeiodinase Is Located in the Plasma Membrane and Undergoes Rapid Internalization to Endosomes* (2003) (123)
Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. (1973) (120)
American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. The Committee on Nomenclature of the American Thyroid Association. (1991) (120)
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. (1992) (120)
The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation (2013) (120)
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. (1992) (118)
The role of selenium in thyroid hormone action. (1992) (118)
The effect of diphenylhydantoin on thyroxine metabolism in man. (1970) (117)
IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells. (2011) (115)
Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. (1990) (115)
Comparison of the biological effects of thyroxine and triiodothyronine in the rat. (1977) (115)
Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA (2013) (114)
Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5'-deiodinases by thyroid hormone. (1984) (110)
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. (2000) (110)
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. (2000) (108)
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. (1998) (108)
The arrestin domain-containing 3 protein regulates body mass and energy expenditure. (2011) (105)
Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. (2006) (104)
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. (1984) (103)
Correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with Graves' disease and subacute thyroiditis. (1978) (98)
The regional hypothalamic distribution of type II 5′-monodeiodinase in euthyroid and hypothyroid rats (1987) (95)
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. (1995) (93)
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity (2011) (93)
A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. (2002) (93)
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (1993) (90)
Neonatal hypothyroidism detected by the Northwest Regional Screening Program. (1979) (90)
Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue. (1986) (90)
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance (2012) (88)
Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves' disease. (1977) (87)
The Human Type 2 Iodothyronine Deiodinase Is a Selenoprotein Highly Expressed in a Mesothelioma Cell Line* (2001) (86)
Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression (2014) (86)
Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. (1999) (85)
β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells. (2012) (83)
Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. (1988) (83)
Cloning and Expression of the Chicken Type 2 Iodothyronine 5′-Deiodinase* (1999) (83)
Partial peripheral resistance to thyroid hormone. (1981) (81)
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. (1977) (81)
Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action (2012) (80)
Thyroxine (T4) Immunoassay Using Filter Paper Blood Samples for Screening of Neonates for Hypothyroidism (1975) (80)
Total and free triiodothyronine and thyroxine in early infancy. (1974) (79)
Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary. (1979) (78)
Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase (1994) (78)
Physiological role and regulation of iodothyronine deiodinases: A 2011 update (2011) (76)
Comprar Williams Textbook of Endocrinology, 12th Edition Expert Consult | Henry M. Kronenberg | 9781437703245 | Saunders (2011) (76)
Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of "cold" thyroid nodules and normal human thyroid tissue. (1972) (76)
Topological Analysis of the Integral Membrane Protein, Type 1 Iodothyronine Deiodinase (D1) (*) (1995) (76)
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. (2003) (73)
Thyroidal triiodothyronine and thyroxine in Graves' disease: correlation with presurgical treatment, thyroid status, and iodine content. (1975) (72)
Characterization of the 5'-Flanking and 5'-Untranslated Regions of the Cyclic Adenosine 3',5'-Monophosphate-Responsive Human Type 2 Iodothyronine Deiodinase Gene1. (2000) (72)
Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity. (1986) (72)
The 3′-Untranslated Region of Human Type 2 Iodothyronine Deiodinase mRNA Contains a Functional Selenocysteine Insertion Sequence Element* (1998) (71)
Amiodarone therapy and autoimmune thyroid disease. Increase in a new monoclonal antibody-defined T cell subset. (1986) (70)
Transcriptional regulation of iodothyronine deiodinases during embryonic development (2001) (69)
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. (2001) (68)
Anatomical distribution of phenolic and tyrosyl ring iodothyronine deiodinases in the nervous system of normal and hypothyroid rats. (1981) (67)
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. (2003) (67)
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. (1993) (67)
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. (2000) (66)
Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries (1988) (66)
Hormonal regulation of iodothyronine 5'-deiodinase in rat brown adipose tissue. (1986) (66)
Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. (1994) (66)
Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase. (2005) (66)
Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase. (1991) (65)
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis. (2016) (65)
Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene. (1998) (65)
Thyroid nodularity after childhood irradiation for lymphoid hyperplasia: a comparison of questionnaire and clinical findings. (1990) (64)
Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. (1992) (64)
Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice. (1995) (63)
The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1). (2001) (63)
Repression mediates cell-type-specific expression of the rat growth hormone gene. (1986) (62)
α1- and β-Adrenergic Agents Cause Synergistic Stimulation of the Iodothyronine Deiodinase in Rat Brown Adipocytes* (1989) (61)
Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. (1991) (61)
Studies of the Hormonal Regulation of Type 2 5'-Iodothyronine Deiodinase Messenger Ribonucleic Acid in Pituitary Tumor Cells Using Semiquantitative Reverse Transcription-Polymerase Chain Reaction* * This work was supported by NIH Grant DK-36256. (1998) (61)
Regulation of thyroxine 5'-deiodinase activity by 3,5,3'-triiodothyronine in cultured rat anterior pituitary cells. (1984) (60)
Recommendations for screening programs for congenital hypothyroidism (1976) (59)
Neonatal thyroid function in congenital hypothyroidism. (1976) (59)
Comprar Williams Textbook of Endocrinology 11th Ed | Kenneth S. Polonsky | 9781416029113 | Saunders (2007) (58)
Immunoassay of human TSH using dried blood samples. (1976) (58)
Familial autoimmune thyroiditis: maternal-fetal relationship and the role of generalized autoimmunity. (1973) (57)
Different pathways of iodothyronine 5'-deiodination in rat cerebral cortex. (1981) (57)
Characterization of the Promoter of the Rat Sarcoplasmic Endoplasmic Reticulum Ca2+-ATPase 1 Gene and Analysis of Thyroid Hormone Responsiveness* (1996) (56)
Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (2003) (55)
Revised nomenclature for tests of thyroid hormones and thyroid-related proteins in serum. (1987) (55)
Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism. (2010) (54)
The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. (2002) (54)
Demonstration of iodide transport defect but normal iodide organification in nonfunctioning nodules of human thyroid glands. (1973) (53)
Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. (2007) (53)
Peripheral metabolism of homologous thyrotropin in euthyroid and hypothyroid rats: acute effects of thyrotropin-releasing hormone, triiodothyronine, and thyroxine. (1978) (52)
Acute deficiency of thyroxine-binding globulin during L-asparaginase therapy. (1979) (52)
Radioimmunoassay for serum thyroxine-binding globulin: results in normal subjects and in patients with hepatocellular carcinoma. (1976) (52)
The basic proteins of cobra venom. I. Isolation and characterization of cobramines A and B. (1968) (52)
Spontaneous Hypoglycemia Associated with Chronic Renal Failure (1973) (52)
Distribution of hypophysiotropic thyrotropin‐releasing hormone (TRH)‐synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse (2010) (51)
Thyroid hormone metabolism in primary cultures of fetal rat brain cells (1985) (51)
Type 2 Iodothyronine Deiodinase Transgene Expression in the Mouse Heart Causes Cardiac-Specific Thyrotoxicosis**This work was supported by grants from the NIH [DK-36256 (to P.R.L.); DK-49126 and DK-53036 (to F.E.W.) and Specialized Center of Research Grant HL-52320 (to J.S.I.)]. (2001) (51)
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. (1992) (50)
Variations in the response of the thyroid gland of the rat to different low-iodine diets: correlation with iodine content of diet. (1976) (50)
Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. (1975) (49)
Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. (2004) (49)
The thyroid hormone-inactivating deiodinase functions as a homodimer. (2008) (48)
Evaluation of urinary cyclic 3'5'-adenosine monophosphate excretion in the differential diagnosis of hypercalcemia. (1972) (48)
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase. (2000) (48)
Divergent changes of thyroxine-5'-monodeiodination in rat pituitary and liver during maturation. (1980) (46)
The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis. (2011) (46)
Studies of nuclear 3,5,3'-triiodothyronine binding in primary cultures of rat brain. (1985) (46)
Bioavailability of thyroid hormones from oral replacement preparations. (1982) (45)
Effects of thyroid-stimulating hormone on human thyroid carcinoma and adjacent normal tissue. (1978) (44)
The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. (2007) (43)
Comparison of thyroxine and 3,3',5'-triiodothyronine metabolism in rat kidney and liver homogenates. (1979) (42)
Plasma T4 and T3 levels in naturally metamorphosing Eurycea bislineata (Amphibia; Plethodontidae). (1986) (42)
Oral thyroxine: variation in biologic action and tablet content. (1984) (42)
Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties. (1999) (42)
The role of 3,3',5'-triiodothyronine in the regulation of type II iodothyronine 5'-deiodinase in the rat cerebral cortex. (1986) (41)
N-acetylcysteine administration prevents nonthyroidal illness syndrome in patients with acute myocardial infarction: a randomized clinical trial. (2014) (40)
Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways. (1995) (40)
Thyroxine to 3,5,3'-triiodothyronine conversion by rat anterior pituitary and liver. (1978) (39)
Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. (1982) (39)
DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity (2000) (39)
Feedback regulation of thyrotropin secretion by thyroid hormones. (1982) (38)
Hormonal content of thyroid replacement preparations. (1980) (38)
Triiodothyronine and thyroxine content of desiccated thyroid tablets. (1977) (38)
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. (1998) (37)
Thyroid function studies in preterm infants recovering from the respiratory distress syndrome. (1977) (37)
Serum triiodothyronine, thyroxine, and thyrotropin during hyperthyroid, hypothyroid, and recovery phases of subacute nonsuppurative thyroiditis. (1974) (36)
Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. (1971) (36)
Maternal thyroxine and congenital hypothyroidism. (1989) (35)
Screening for congenital hypothyroidism. Results in the newborn population of New England. (1978) (35)
Transient neonatal hypothyroidism detected by newborn screening program. (1977) (34)
In vitro 3,5,3'-triiodothyronine binding to rat cerebrocortical neuronal and glial nuclei suggests the presence of binding sites unavailable in vivo. (1985) (33)
Recommendations for screening programs for congenital hypothyroidism. Report of a committee of the American Thyroid Association. (1976) (33)
Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress. (1993) (33)
Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. (1978) (33)
Structure-Activity Relationships for Thyroid Hormone Deiodination by Mammalian Type I Iodothyronine Deiodinases1. (1997) (32)
Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle. (2011) (32)
Measurement of free thyroid hormones in serum by dialysis and gas chromatography. (1977) (32)
Is there a negative TRE in the luciferase reporter cDNA? (1996) (31)
Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases. (1997) (30)
Biochemical observations in functioning human thyroid adenomas. (1973) (30)
The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. (2015) (30)
A Cohort Analysis of Clinical and Ultrasound Variables Predicting Cancer Risk in 20,001 Consecutive Thyroid Nodules. (2019) (30)
Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone. (1997) (29)
Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice. (2011) (29)
Insulin stimulation of iodothyronine 5'-deiodinase in rat brown adipocytes. (1987) (28)
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase. (2011) (28)
The basic proteins of cobra venom. II. Mechanism of action of cobramine B on thyroid tissue. (1968) (28)
The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule. (1993) (27)
Differential Growth Rates of Benign vs. Malignant Thyroid Nodules (2017) (27)
Quantitative Analysis of the Benefits and Risk of Thyroid Nodule Evaluation in Patients ≥70 Years Old. (2018) (27)
Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation. (2009) (27)
Subcellular distribution of iodothyronine 5'-deiodinase in cerebral cortex from hypothyroid rats. (1982) (26)
Radioiodine for thyroid cancer--is less more? (2012) (26)
Catecholamine stimulation of iodothyronine 5'-deiodinase activity in rat dispersed brown adipocytes. (1987) (26)
In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines (1996) (25)
Di Guglielmo's syndrome after polycythemia. (1966) (25)
The Guanosine Monophosphate Reductase Gene Is Conserved in Rats and Its Expression Increases Rapidly in Brown Adipose Tissue during Cold Exposure* (1998) (25)
Formation of 3,3'-diiodothyronine and 3',5',3-triiodothyronine (reverse T3) in thyroid glands of rats and in enzymatically iodinated thyroglobulin. (1976) (25)
Hypothyroidism During Tyrosine Kinase Inhibitor Therapy Is Associated with Longer Survival in Patients with Advanced Nonthyroidal Cancers. (2018) (24)
Screening for Congenital Hypothyroidism (1978) (24)
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. (2001) (24)
Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells. (2008) (23)
The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase. (1997) (23)
Risk Factors for New Hypothyroidism During Tyrosine Kinase Inhibitor Therapy in Advanced Nonthyroidal Cancer Patients. (2018) (23)
Iodide Transport: Inhibition by Agents Reacting at the Membrane (1967) (23)
Comparison of kidney and brown adipose tissue iodothyronine 5'-deiodinases. (1987) (23)
The toxic proteins of cobra venom. (1968) (22)
Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells. (1999) (22)
Tests of thyroid function. (1975) (22)
New guidelines for patients with thyroid nodules and differentiated thyroid cancer (2006) (21)
Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. (2013) (21)
Effect of TSH on iodine metabolism and intermediary metabolism in tissue from patients with Graves' disease. (1974) (21)
How are childhood thyroid nodules discovered: opportunities for improving early detection. (2014) (21)
Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma. (2016) (21)
The American Thyroid Association: d'où venons nous? Que sommes nous? Où allons nous? (Whence do we come? What are we? Where are we going?). (1995) (21)
Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum. (1971) (21)
Studies on the mechanism of 3,5,3'-triiodothyronine-induced suppression of secretagogue-induced thyrotropin release in vitro. (1981) (20)
12 – Intrapituitary Mechanisms in the Control of TSH Secretion (1983) (20)
Thyroid hormone inactivation in gastrointestinal stromal tumors. (2014) (20)
Metabolic clearance of endogenous and radioiodinated thyroglobulin in rats. (1978) (20)
Direct radioimmunoassay of nuclear 3,5,3' triiodothyronine in rat anterior pituitary. (1980) (20)
Hypothyroidism may accompany SU11248 therapy in a subset of patients (pts) with metastatic (met) gastrointestinal stromal tumors (GIST) and is manageable with replacement therapy (2005) (19)
Thyroxine reverses deficits of nerve growth factor and epidermal growth factor in submandibular glands of mice with muscular dystrophy. (1982) (19)
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells. (2010) (18)
Type-2 iodothyronine 5'deiodinase in skeletal muscle of C57BL/6 mice. I. Identity, subcellular localization, and characterization. (2011) (17)
Thyroid hormone and adrenergic signaling in the heart. (2004) (17)
Evidence for a possible role for Ca++ in the 3,5,3'-triiodothyronine inhibition of thyrotropin-releasing hormone-induced secretion of thyrotropin by rat anterior pituitary in vitro. (1981) (17)
Effect of thyroid status on catecholamine stimulation of thyroxine 5'-deiodinase in brown adipocytes. (1989) (16)
Commentary: Monitoring Thyroxine Treatment During Pregnancy (1992) (16)
Long-term, treatment-free survival in select patients with distant metastatic papillary thyroid cancer (2014) (16)
Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study. (2008) (15)
Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes. (1988) (15)
Nuclear triiodothyronine binding in mononuclear leukocytes in normal subjects and obese patients before and after fasting. (1982) (14)
Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. (1996) (14)
Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat. (1985) (14)
Phorbol esters as probes of the regulation of thyrotropin secretion. (1984) (14)
Effects of weekly thyroxine administration on serum thyroxine, 3,5,3'-triiodothyronine, thyrotropin, and the thyrotropin response to thyrotropin-releasing hormone. (1980) (14)
T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells (2018) (13)
Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid. (2009) (13)
Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase. (1993) (13)
RTHα, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations. (2013) (13)
Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction. (1994) (13)
Revised nomenclature for tests of thyroid hormones and thyroid-related proteins in serum. (1987) (12)
The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency. (1996) (12)
Pyrazole-induced thyroid necrosis: a distinct organ lesion. (1978) (12)
CHAPTER 12 – Thyrotoxicosis (2011) (11)
A new partnership (2006) (11)
THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter Thyroid Supplements. (2016) (11)
Alpha 1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. (1989) (11)
Functional analysis of novel genetic variation in the thyroid hormone activating type 2 deiodinase. (2014) (11)
Basic and clinical endocrinology (1981) (10)
A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. (2004) (10)
Thyroid-pituitary feedback during iodine repletion. (1976) (10)
Thyroid hormone analogs and metabolites: new applications for an old hormone? (2009) (9)
The pituitary-thyroid regulatory system. (1989) (9)
Triiodothyronine causes rapid reversal of alpha 1/cyclic adenosine monophosphate synergism on brown adipocyte respiration and type II deiodinase activity. (1991) (9)
A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice. (2019) (8)
Neonatal Thyroid Function after Propylthiouracil Therapy for Maternal Gravesʼ Disease (1981) (8)
Inhibition of accumulative transport by a protein from cobra venom. (1967) (8)
Selenium, deiodinases and endocrine function (2006) (8)
Thyroid Hormone Promotes Postnatal Rat Pancreatic b-Cell Development and Glucose-Responsive Insulin (2013) (8)
Mammalian type 2 deiodinase sequences: finally, the end of the beginning. (1996) (7)
Cost-Effectiveness of Screening for Hypo- and Hyperthyroidism in India (1981) (6)
Subacute thyroiditis in a lateral thyroid gland: evaluation of the pituitary-thyroid axis during the acute destructive and the recovery phases. (1975) (6)
A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration. (2020) (6)
CHAPTER 1 – Principles of Endocrinology (2011) (6)
NEONATAL HYPOTHYROIDISM DETECTED BY THE OREGON REGIONAL SCREENING PROGRAM (1977) (5)
Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element. (1996) (5)
Functional Analysis of Genetic Variation in the SECIS Element of Thyroid Hormone Activating Type 2 Deiodinase. (2018) (4)
The Deiodinases: their Identification and Cloning of their Genes. (2021) (4)
Control of Thyroid Hormone Activation and Inactivation by the Iodothyronine Deiodinase Family of Selenoenzymes (2011) (4)
Decade in review—thyroid disease: The endocrinology of thyroid disease from 2005 to 2015 (2015) (4)
Photoaffinity labeling of rat type I iodothyronine deiodinase. (1991) (4)
Cardiovascular and metabolic issues in patients with thyroid dysfunction will be highlighted at the Fifth Anniversary of ATA Spring Meetings in March 2008. (2008) (3)
Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation. (2012) (3)
Regulation of Thyroid Hormone Metabolism in the Brain (1989) (3)
CARs and drugs: a risky combination. (2005) (3)
In vitro demonstration of iodide-trapping defect but normal thyrotropin (TSH) responsiveness in benign and malignant "cold" thyroid nodules. (1972) (3)
The Role of Selenocysteine 133 in Catalysis by the Human Type 2 Iodothyronine Deiodinase* *This work was supported by NIH Grant R01-DK-36256. (2000) (3)
Editor's column: Recommendations for screening programs for congenital hypothyroidism. Report of a Committee of The American Thyroid Association. (1976) (3)
Prospective studies of thyroid function in patients receiving gold therapy. (1995) (3)
Insulin, Glucose, and Glucagon are Potential Modulators of Thyroid Hormone Action Through Brown Adipose Tissue 5′-Deiodinase in Rats (1986) (2)
The Basic Proteins of Cobra Venom (2003) (2)
Tissue-Specific Regulation of Thyroid Status by Selenodeiodinases (2016) (2)
Modulation of Deiodinase Types 2 and 3 during Skeletal Muscle Regeneration (2022) (2)
Response: Re: Thyroid Dysfunction from Antineoplastic Agents (2012) (2)
Ultrasonography in Management of Nodular Thyroid Disease (2001) (1)
Screening for congenital hypothyroidism: of screening one million North American Results infants (1979) (1)
Levothyroxine Therapy (1994) (1)
Not just another journal (2005) (1)
Regulation of thyrotropin secretion in nonthyroidal illness. (1986) (1)
Thyroid hormone metabolism in the central nervous system. (1988) (1)
Unilateral proptosis due to orbital pseudotumor in a patient with Hashimoto's thyroiditis. (1972) (1)
Detecting and treating hypothyroidism during pregnancy (2006) (1)
Monitoring thyroxine treatment during pregnancy. (1992) (1)
Regulation of thyrotropin secretion by 3,5,3'-triiodothyronine and thyroxine. (1981) (1)
Van Meter Prize of the American Thyroid Association to Gregory Brent. (1997) (0)
Results of Repeated Analysis for FT 3 and FT 4 in a Specimen of Pooled Serum , with Use of the Internal Standard (2004) (0)
Anatomic Pathology / SFNHCT in Hashimoto Thyroiditis (2010) (0)
Dr Joseph Edward Rall (2008) (0)
Immunometric assays may underestimate thyrotropin concentrations in sera from infants with congenital hypothyroidism. (1988) (0)
Good news from MEDLINE—and how you can help us stay one step ahead (2006) (0)
Antiestrogens stimulate expression of transiently transfected and endogenous genes in rat pituitary tumor cell lines (1991) (0)
Insights from the 77th annual meeting of the American Thyroid Association (2007) (0)
The Effect of $T_3$ on Thyroid Hormone Receptor Dynamics in Thyroid Hormone Response Element of Chicken Lysozyme Silencer (2003) (0)
Thyroxine-induced induction of pyroglutamyl peptidase II and inhibition of TSH release 1 precedes suppression of TRH mRNA and requires type 2 deiodinase 2 3 Abbreviated Title: Requirements for T4-induced TSH suppression 4 5 (2011) (0)
Mechanisms Controlling Deiodinase Activity (2001) (0)
Pituitary Cells Respond to Thyroid Discrete, Gene-Specific Pathways Hormone (1995) (0)
Endocrinology and oncology: closer ties will be mutually beneficial (2008) (0)
Major Accomplishments of Four Decades of Research on the Thyroid Gland (2010) (0)
Insights from the ENDO 2005 meeting (2005) (0)
Thirty-Fifth Annual Postgraduate Assembly of The Endocrine Society (1983) (0)
Responsiveness to thyrotropin in primary thyroidal failure. (1972) (0)
Tranquil Plasma Surrounding an Intracellular Storm (2005) (0)
Evaluation of suspected thyroid dysfunction. (1977) (0)
Kinetic evidence suggesting two mechanisms for iodothyronine (0)
In vitro demonstration of normal thyrotropin (TSH) responsiveness in thyroid tissue from patients with Graves' disease. (1973) (0)
Alvin M. Taurog, Ph.D. (2006) (0)
Thyroid physiology becomes more complicated (2007) (0)
Thyroid Hormone Receptor Dynamics in Thyroid Hormone Response Elements of the Human type 1 Iodothyronone Deiodinase Gene (2003) (0)
Long-term, Treatment-free Survival in Select Patients with (2014) (0)
Hypertensive Traits: The Framingham Heart Study Lack of Association Between the Type 2 Deiodinase A/G Polymorphism and (2011) (0)
SUBACUTE THYROIDITIS IN AN ECTOPIC THYROID GLAND, EVALUATION OF THYROID-PITUITARY RESPONSE DURING HYPERTHYROID, HYPOTHYROID AND RECOVERY PHASE (1974) (0)
Neonatal thyroid function hypothyroidism in congenital (1976) (0)
Insights from the 78th Annual Meeting of the American Thyroid Association (2008) (0)
SAT-LB095 The Role of Type 2 Deiodinase in Interactions Between Muscle Stem Cells and Endothelial Cells (2019) (0)
Short Communication Genetic and Biological Subgroups of Low-Stage Follicular Thyroid Cancer (2003) (0)

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