Patrick Ralph
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Cell Biology
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Immunology
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Biology
Patrick Ralph's Degrees
- PhD Immunology University of California, San Francisco
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Patrick Ralph's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Functional macrophage cell lines transformed by abelson leukemia virus (1978) (850)
- Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity (1991) (729)
- Human Leukemic Models of Myelomonocytic Development: A Review of the HL‐60 and U937 Cell Lines (1985) (625)
- Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications (2001) (544)
- Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity. (1975) (397)
- Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity. (1986) (393)
- Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines (1976) (367)
- Murine B cell leukemia line with inducible surface immunoglobulin expression. (1978) (332)
- Transforming potential of the c-fms proto-oncogene (CSF-1 receptor) (1987) (293)
- Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia (1976) (290)
- Identification of three related human GRO genes encoding cytokine functions. (1990) (280)
- Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS. (1977) (279)
- Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. (1993) (261)
- Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line (1975) (254)
- Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. (1988) (228)
- Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes (1987) (200)
- Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor. (1991) (197)
- Induction of prostaglandin E synthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation. (1979) (197)
- Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1. (1991) (157)
- Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes. (1991) (143)
- Specificity and modulation of the action of lactoferrin, a negative feedback regulator of myelopoiesis. (1980) (136)
- Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2. (1984) (134)
- Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC). (1988) (133)
- Three distinct stages of B-cell defects in common varied immunodeficiency. (1982) (125)
- Retention of lymphocyte characteristics by myelomas and theta + -lymphomas: sensitivity to cortisol and phytohemagglutinin. (1973) (123)
- Differences in the surface proteins of mouse B and T cells. (1975) (122)
- Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic or macrophage tumor cells in culture. (1977) (118)
- Lymphokine inducing "terminal differentiation" of the human monoblast leukemia line U937: a role for gamma interferon. (1983) (113)
- COMPARATIVE ANALYSIS OF THE HUMAN MACROPHAGE INFLAMMATORY PROTEIN FAMILY OF CYTOKINES (CHEMOKINES) ON PROLIFERATION OF HUMAN MYELOID PROGENITOR CELLS (1993) (109)
- Cell-free granulocyte colony inhibiting activity derived from human polymorphonuclear neutrophils. (1977) (105)
- Distinct activities of interferon-gamma, lymphokine and cytokine differentiation-inducing factors acting on the human monoblastic leukemia cell line U937. (1985) (101)
- Growth of B-lymphocytes clones in semisolid culture is mitogen dependent (1976) (100)
- Macrophage factor controlling differentiation of B cells. (1979) (96)
- The role of humoral factors in the initiation of in vitro primary immune responses. II. Effects of lymphocyte mitogens. (1973) (89)
- Stimulation of macrophage tumoricidal activity by the growth and differentiation factor CSF-1. (1987) (88)
- Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation. (1986) (83)
- Monocyte-macrophage-derived acidic isoferritins: Normal feedback regulators of granulocyte-macrophage progenitor cells in vitro (1982) (79)
- Functional Subsets of Murine and Human B Lymphocyte Cell Lines (1979) (71)
- Differential Expression of M‐CSF, G‐CSF, and GM‐CSF by Human Monocytes (1990) (71)
- Expression and induction in vitro of macrophage differentiation antigens on murine cell lines. (1983) (70)
- Oncogenic transformation of murine lymphoid cells by in vitro infection with Abelson leukemia virus. (1975) (69)
- Lymphosarcoma cell growth is selectively inhibited by B lymphocyte mitogens: LPS, dextran sulfate and PPD. (1974) (67)
- Enhanced stimulation of human bone marrow macrophage colony formation in vitro by recombinant human macrophage colony-stimulating factor in agarose medium and at low oxygen tension. (1990) (67)
- All classes of murine IgG antibody mediate macrophage phagocytosis and lysis of erythrocytes. (1980) (66)
- A non-radioactive complement-dependent cytotoxicity assay for anti-CD20 monoclonal antibody. (1997) (63)
- Lactoferrin, transferrin and acidic isoferritins: regulatory molecules with potential therapeutic value in leukemia. (1983) (62)
- Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. (1989) (60)
- The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors. (1987) (60)
- Inducible production of human macrophage growth factor, CSF-1 (1986) (59)
- Induction of antibody-dependent and nonspecific tumor killing in human monocytic leukemia cells by nonlymphocyte factors and phorbol ester. (1982) (58)
- Cell interactions influencing murine marrow megakaryocytes: nature of the potentiator cell in bone marrow. (1981) (57)
- Cell-specific antigens and immunoglobulin synthesis of murine myeloma cells and their variants. (1972) (57)
- Induction of human immunoglobulin secretion. I. Synergistic effect of B cell mitogen Cowan I plus T cell mitogens or factors. (1981) (57)
- Biological properties and molecular biology of the human macrophage growth factor, CSF-1. (1986) (56)
- Corticosteroids block newly induced but not constitutive functions of macrophage cell lines: myeloid colony-stimulating activity production, latex phagocytosis, and antibody-dependent lysis of RBC and tumor targets. (1978) (56)
- Human upper airway structural cell-derived cytokines support human peripheral blood monocyte survival: a potential mechanism for monocyte/macrophage accumulation in the tissue. (1992) (55)
- Role of interleukin 2, interleukin 4, and alpha, beta, and gamma interferon in stimulating macrophage antibody-dependent tumoricidal activity (1988) (55)
- Induction of myeloid colony-stimulating activity in murine monocyte tumor cell lines by macrophage activators and in a T-cell line by concanavalin A. (1978) (55)
- Immunostimulators induce granulocyte/macrophage colony-stimulating activity and block proliferation in a monocyte tumor cell line (1977) (54)
- Monocyte-macrophage-derived acidic isoferritins: normal feedback regulators of granulocyte-macrophage progenitor cells in vitro. (1982) (51)
- A subpopulation of human polymorphonuclear neutrophils contains an active form of lactoferrin capable of binding to human monocytes and inhibiting production of granulocyte-macrophage colony stimulatory activities. (1980) (50)
- Clonal differences in response to T cell replacing factor (TRF) for IgM secretion and TRF receptors in a human B lymphoblast cell line (1983) (49)
- Inhibitory effects of lectins and lymphocyte mitogens on murine lymphomas and myelomas. (1973) (47)
- Endogenous pyrogen production by Hodgkin's disease and human histiocytic lymphoma cell lines in vitro. (1980) (47)
- Independent control of immunoglobulin heavy and light chain expression in a murine pre-B-cell line (1981) (47)
- Distinct differentiation-inducing activities of gamma-interferon and cytokine factors acting on the human promyelocytic leukemia cell line HL-60. (1985) (47)
- Differentiation of the IL-3-dependent NFS-60 cell line and adaption to growth in macrophage colony-stimulating factor. (1990) (45)
- Leukemia viruses associated with mouse myeloma cells. (1970) (44)
- Cell-mediated lysis of tumor targets directed by murine monoclonal antibodies of IgM and all IgG isotypes. (1983) (43)
- Induction of IgG production in human B lymphoblastoid cell lines with normal human T cells (1978) (43)
- Inducible production of human macrophage growth factor, CSF-1. (1986) (41)
- In vitro regulation of a mouse myelomonocytic leukemia line adapted to culture. (1977) (40)
- Colony-stimulating factors and regulation of macrophage tumoricidal and microbicidal activities. (1983) (39)
- Lipopolysaccharides inhibit lymphosarcoma cells of bone marrow origin (1974) (35)
- Differences in antibody-dependent cellular cytotoxicity and activated killing of tumor cells by macrophage cell lines. (1981) (34)
- In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients (1991) (34)
- Functions of Macrophage Cell Lines (1980) (33)
- Suppression of spleen natural killing activity induced by BCG. (1980) (32)
- Stimulation of macrophage antibody-dependent killing of tumor targets by recombinant lymphokine factors and M-CSF. (1988) (32)
- Interleukin-2 correction of defectivein vitro T-cell mitogenesis in patients with common varied immunodeficiency (1984) (30)
- Characteristics of bone marrow and blood cells in human leukemia that produce leukemia inhibitory activity (LIA). (1979) (30)
- Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines. (1981) (29)
- Anti‐tumor effects of recombinant human macrophage colony‐stimulating factor, alone or in combination with local irradiation, in mice inoculated with lewis lung carcinoma cells (1991) (28)
- In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients. (1991) (28)
- In vitro immune response of human peripheral lymphocytes. IV. Specific induction of human suppressor T cells by an antiserum to the T leukemia cell line HSB. (1979) (27)
- Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma. (1973) (27)
- The role of humoral factors in the initiation of in vitro primary immune responses. IV. Are macrophages the adherent cell type required for cell cooperation. (1973) (26)
- Molecular and biological properties of human macrophage growth factor, CSF-1. (1986) (25)
- Recombinant human granulocyte‐colony stimulating factor and recombinant human macrophage colony stimulating factor synergize in vivo to enhance proliferation of granulocyte‐macrophage, erythroid, and multipotential progenitor cells in mice (1988) (25)
- Human B cell-inducing factor(s) for production of IgM, IgG and IgA: independence from IL 2. (1984) (25)
- In vitro stimulation of phagocytosis in a macrophage cell line measured by a convenient radiolabeled latex bead assay. (1979) (24)
- Induction of leukemia-associated inhibitory activity and bone marrow granulocyte-macrophage progenitor cell alterations during infection with Abelson virus. (1980) (22)
- Environmental and chemical dissociation of antibody-dependent phagocytosis from lysis mediated by macrophages: stimulation of lysis by sulfhydryl-blocking and esterase-inhibiting agents and depression by trypan blue and trypsin. (1980) (21)
- Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts. (1989) (21)
- Distinct signals for antibody-dependent and nonspecific killing of tumor targets mediated by macrophages. (1982) (21)
- Regulation of clonal B-lymphocyte proliferation by anti-immunoglobulin or anti-Ia antibodies. (1977) (20)
- Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I. Isolation, characterization, cell surface markers, and B-cell markers. (1982) (19)
- Tumor promoter phorbol myristic acetate is a T-cell dependent inducer of immunoglobulin secretion in human lymphocytes. (1982) (18)
- The Molecular and Biological Properties of the Human and Murine Members of the CSF-1 Family (1987) (17)
- Specific inhibitory activity against granulocyte-progenitor cells produced by non-T lymphocytes from patients with neutropenia. (1980) (16)
- A macrophage tumor cell line and plasminogen activator. A potential model system for macrophage regulation of enzyme production (1978) (16)
- Expression of v-fms and c-fms in the hemopoietic cell line FDC-P1. (1990) (14)
- Suppression of natural killer activity in human blood and bone marrow cultures by bone marrow-adherent OKM1-positive cells. (1983) (14)
- IgM‐ and IgD‐bearing peripheral blood lymphocytes differentiate to IgM but not IgG or IgA immunoglobulin‐secreting cells (1982) (14)
- CONTINUOUS CELL LINES WITH PROPERTIES OF MONONUCLEAR PHAGOCYTES (1981) (12)
- Phenotypic and cytogenetic characteristics of a new epstein‐barr virus negative cell line (SKW 4) derived from A B‐Cell lymphoma (2007) (12)
- Suppression and restoration of cytotoxic T-cell activity during chemotherapy of a mouse T-cell lymphoma and a macrophage tumor. (1978) (12)
- IgM and IgG secretion in human B-cell lines regulated by B-cell-inducing factors (BIF) and phorbol ester. (1983) (12)
- Efficacy of recombinant human macrophage colony-stimulating factor in combination with whole-body hyperthermia in the treatment of mice infected with the polycythemia-inducing strain of the Friend virus complex. (1991) (10)
- Stimulation of a human B-lymphocyte line by anti-immunoglobulin and its concanavalin A-induced suppression by a T-cell line. (1977) (9)
- Novel humanized anti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions. (1992) (9)
- Cooperation of IgG Monoclonal Antibodies in Macrophage Antibody‐Dependent Cellular Cytotoxicity (ADCC) to Tumor Targets (1984) (9)
- Immunologic functions and in vitro activation of cultured macrophage tumor lines. (1978) (9)
- Induction of human immunoglobulin secretion. II. T lymphocyte dependency and radiosensitivity of T-cell help for induction of B-cell differentiation by Staphylococcus aureus strain Cowan I. (1982) (9)
- Antibody dependent cellular immunity in newborn mice. (1973) (8)
- Biochemical characterization and purification of human B cell stimulatory factor (BSF) (1985) (8)
- Activation of cyclic AMP-dependent protein kinase activity during LPS stimulation of macrophage tumor cell line, J774.1. (1981) (7)
- Sensitivity to chemotherapeutic and immunomodulating agents of two mouse lymphomas and of a macrophage tumor. (1979) (7)
- Synergistic interaction of hematopoietic colony stimulating and growth factors in the regulation of myelopoiesis. (1988) (7)
- IgM-IgG1, 2, 3 Relationship during Pregnancy (1972) (6)
- Molecular biology, cell biology and clinical future of myeloid growth factors. (1989) (5)
- Rescue of IgM, IgG, and IgA production in common varied immunodeficiency by T cell-independent stimulation with Epstein-Barr virus (1985) (5)
- Activating factors for nonspecific and antibody-dependent cytotoxicity by human and murine mononuclear phagocytes. (1984) (5)
- Effector Cell Functions in Long-Term Culture of Murine, Prosimian, and Human Bone Marrow (1980) (5)
- Induction of human immunoglobulin secretion. III. Inhibition of induction of IgG and IgA production in spleen but not peripheral blood cells by mitogenic antibody to IgM and IgD. (1982) (4)
- Augmentation of macrophage antibody-dependent killing of tumor targets by microtubule inhibitors. (1982) (4)
- The human B-cell lineage cell line ARH-77. (1985) (4)
- Negative Regulation of Cytokines Inhibition of the Production of Interleukin‐1 and Tumor Necrosis Factor (1991) (4)
- Synergistic effects of human B and T lymphocyte mitogens induce uniform, high levels of immunoglobulin secretion among normal donors. (1981) (3)
- Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. (1992) (3)
- MECHANISM OF SURFACE MEMBRANE EXPRESSION IN MURINE B-LYMPHOCYTE CELL LINES (1979) (3)
- Molecular properties and biological activity of human macrophage growth factor, CSF-1. (1987) (3)
- Lymphokine factors inducing IgG production in human B-cell line ARH-77 and stimulatory effects of phorbol ester tumor promoter. (1983) (3)
- ACTIVITY OF MACROPHAGE CELL LINES IN SPONTANEOUS AND LPS, LYMPHOKINE OR ANTIBODY-DEPENDENT KILLING OF TUMOR TARGETS (1980) (3)
- Matching of chemotherapy to mouse strain and lymphoid tumor type to prevent tumor-induced suppression of specific T- and B-cell functions. (1979) (3)
- Differentiation and Functional Regulation in Macrophage Cell Lines (1984) (2)
- Independent regulation of B-cell inducing factor and IL-2 production by T lymphocytes, and direct and indirect promotion of immunoglobulin secretion by glucocorticosteroid. (1986) (2)
- Monoblast Leukemia Line U937: A Role for 'y Interferon (1983) (2)
- THE ROLE OF SHEAR STRESS IN THE GENERATION OF DEFINITIVE HAEMATOPOIETIC LINEAGES AND ARTERIAL VASCULATURE FROM HUMAN PLURIPOTENT STEM CELLS AT THE SINGLE-CELL LEVEL (2019) (2)
- T-cell growth factor (Interleukin 2) and terminal transferase activity in human leukemias and lymphoblastic cell lines (1981) (2)
- Clinical and preclinical studies presented at the Keystone Symposium on Arthritis, Related Diseases, and Cytokines. (1993) (1)
- Regulation †̃of the growth and production of granubocyte colony-stimulating activity (CSA) by WEHI-3 cells, a lyso (2006) (0)
- The involvement of macrophages in murine megakaryocyte development. Abstr. (1978) (0)
- Cytotoxicity in promyelocytic cell lines. (1983) (0)
- XVIIIth Congress of the international society for experimental hematology, Paris, July 16-20, 1989 : some presentations on regulatory molecules (1990) (0)
- Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF) (1989) (0)
- interleukin-2 in cancer patients (see comments) interleukin-6 during intravenous administration of high-dose stimulating factor, macrophages colony-stimulating factor, and In vivo production of interleukin-5, granulocyte-macrophage colony- (2013) (0)
- Enhancement of macrophage cytotoxicity to tumors and production of megakaryocyte-stimulating factors by microbial agents. (1980) (0)
- Cloning of murine b lymphocytes in semisolid culture. Growth requirements and sensitivity to anti-immunoglobulin (ig). Abstr. (1976) (0)
- Program and Abstracts of the 23rd NATIONAL MEETING OF THE RETICULOENDOTHELIAL SOCIETY (1986) (0)
- 82. Suppressive effects of human proinflammatory cytokines on proliferation of human myeloid progenitor cells (1992) (0)
- Use of recombinant colony stimulating factor-1 for the manufacture of a medicament against cytomegalovirus (1988) (0)
- GENETIC CONTROL OF MACROPHAGE DIFFERENTIATION AND FUNCTION: Chairman's Summary (1980) (0)
- (iodination/lymphocytes/mitogens/polyacrylamide gels/. (2016) (0)
- INDUCTION OF SURFACE IMMUNOGLOBULIN (sIg) EXPRESSION ON A MURINE B-CELL LEUKEMIA BY LIPOPOLYSACCHARIDE (LPS) (1978) (0)
- regulators of granulocyte-macrophage progenitor cells in vitro Monocyte-macrophage-derived acidic isoferritins: normal feedback (2011) (0)
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