Pam Sykes
Australian medical scientist
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Pam Sykes's Degrees
- Masters Medical Research University of Melbourne
- PhD Medical Science Monash University
Why Is Pam Sykes Influential?
(Suggest an Edit or Addition)According to Wikipedia, Pamela Sykes is an Australian medical scientist and Chair of the Institutional Biosafety Committee at the Flinders Centre for Innovation in Cancer at Flinders University. She is a Strategic Professor in the area of Preventive Cancer Biology and leads a research group which studies the biological effects of low-dose radiation. She is a member of the Radiation Protection Committee which advises the Government of South Australia. Her research has been published in Radiation Research, Epigenetics, Transgenic Research, Cell Biology and Toxicology, PLOS ONE, Mutation Research and the Journal of Clinical Pathology. She is an Associate Editor for the journal Radiation Research. Sykes' research into the effects of low-dose ionising radiation has been funded by the United States Department of Energy's Low Dose Radiation Research Program since the early 2000s.
Pam Sykes's Published Works
Published Works
- Elevated levels of versican but not decorin predict disease progression in early-stage prostate cancer. (1998) (196)
- Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures? (2011) (186)
- The Linear No-Threshold Model does not Hold for Low-Dose Ionizing Radiation (2004) (122)
- Relationship between minimal residual disease and outcome in adult acute lymphoblastic leukemia. (1996) (119)
- PROLONGATION OF SHEEP CORNEAL ALLOGRAFT SURVIVAL BY EX VIVO TRANSFER OF THE GENE ENCODING INTERLEUKIN-101 (2001) (115)
- Elevated stromal chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer. (1997) (88)
- Use of DNA polymorphisms and the polymerase chain reaction to examine the survival of a human limbal stem cell allograft. (1995) (74)
- Adaptive Response for Chromosomal Inversions in pKZ1 Mouse Prostate Induced by Low Doses of X Radiation Delivered after a High Dose (2007) (61)
- Effect of Exposure to 900 MHz Radiofrequency Radiation on Intrachromosomal Recombination in pKZ1 Mice (2001) (55)
- Extremely Low Priming Doses of X Radiation Induce an Adaptive Response for Chromosomal Inversions in pKZ1 Mouse Prostate (2006) (55)
- Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia. (2003) (54)
- Comparison of myeloma cell contamination of bone marrow and peripheral blood stem cell harvests (1996) (53)
- Prolongation of Sheep Corneal Allograft Survival by Transfer of the Gene Encoding Ovine IL-12-p40 but Not IL-4 to Donor Corneal Endothelium1 (2005) (52)
- Non-linear chromosomal inversion response in prostate after low dose X-radiation exposure. (2006) (47)
- Lack of IL-2 cytokine expression despite Il-2 messenger RNA transcription in tumor-infiltrating lymphocytes in primary human breast carcinoma: selective expression of early activation markers. (1996) (47)
- Characterization of clonal immunoglobulin heavy chain and I cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia. (1995) (40)
- Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. Australian and New Zealand Children's Cancer Study Group. (1993) (40)
- Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis (2012) (32)
- Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo (2017) (31)
- Induction of somatic intrachromosomal recombination inversion events by cyclophosphamide in a transgenic mouse model. (1997) (31)
- Inversion due to intrachromosomal recombination produced by carcinogens in a transgenic mouse model. (1999) (27)
- In Vivo Mutagenic Effect of Very Low Dose Radiation (2006) (27)
- Dose-dependent increase or decrease of somatic intrachromosomal recombination produced by etoposide. (2002) (25)
- Gene transfer to ovine corneal endothelium (2001) (25)
- Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent (2014) (24)
- The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer (2017) (23)
- Low dose X-radiation adaptive response in spleen and prostate of Atm knockout heterozygous mice (2007) (22)
- Idiotypic oligonucleotide probes to detect myeloma cells by mRNA in situ hybridization (1995) (22)
- The Methylation of DNA Repeat Elements is Sex-Dependent and Temporally Different in Response to X Radiation in Radiosensitive and Radioresistant Mouse Strains (2014) (21)
- Extremely Low Doses of X-Radiation can Induce Adaptive Responses in Mouse Prostate (2007) (20)
- Sensitive and specific measurement of minimal residual disease in acute lymphoblastic leukemia. (2009) (20)
- The PKZ1 Recombination Mutation Assay: A Sensitive Assay for Low Dose Studies (2006) (20)
- Local gene transfer to modulate rat corneal allograft rejection. (2005) (19)
- A rapid method for the detection of monoclonality in B cell lymphoma in lymph node aspirates using the polymerase chain reaction. (1992) (19)
- Effects of oestradiol-17β and 5α-dihydrotestosterone on guinea-pig prostate smooth muscle cell proliferation and steroid receptor expression in vitro (1994) (18)
- IgE+ cells in the peripheral blood of atopic, nonatopic, and bee venom-hypersensitive individuals exhibit the phenotype of highly differentiated B cells. (1995) (16)
- Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. (2004) (16)
- A Single Whole-Body Low Dose X-Irradiation Does Not Affect L1, B1 and IAP Repeat Element DNA Methylation Longitudinally (2014) (15)
- Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia. (2009) (14)
- An Adoptive Transfer Method to Detect Low-Dose Radiation-Induced Bystander Effects In Vivo (2010) (14)
- If Bystander Effects for Apoptosis Occur in Spleen after Low-Dose Irradiation In Vivo then the Magnitude of the Effect Falls within the Range of Normal Homeostatic Apoptosis (2010) (12)
- Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation (2020) (11)
- Requirements for Identification of Low Dose and Non-Linear Mutagenic Responses to Ionising Radiation (2007) (10)
- Lack of interleukin-2 (IL-2) cytokine expression despite IL-2mRNA transcription in tumour infiltrating lymphocytes in primary human breast carcinoma : selective expression of early activation markers (1996) (10)
- Environmentally Relevant Chronic Low-Dose Tritium and Gamma Exposures do not Increase Somatic Intrachromosomal Recombination in pKZ1 Mouse Spleen (2016) (10)
- MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance (2020) (9)
- The Combination of Metformin and Valproic Acid Has a Greater Anti-tumoral Effect on Prostate Cancer Growth In Vivo than Either Drug Alone (2018) (9)
- Combination Therapies Using Metformin and/or Valproic Acid in Prostate Cancer: Possible Mechanistic Interactions. (2019) (9)
- Longitudinal analysis of circulating myeloma cells detected by allele specific mRNA in situ hybridization (1998) (8)
- False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models (2013) (8)
- Effects of Low Doses of Radiation: Joint Statement from the Following Participants at the 15th Pacific Basin Nuclear Conference, Sessions Held in Sydney, Australia, Wednesday 18 October 2006 (2007) (5)
- Effects of oestradiol-17 beta and 5 alpha-dihydrotestosterone on guinea-pig prostate smooth muscle cell proliferation and steroid receptor expression in vitro. (1994) (5)
- Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide (2018) (5)
- Purging of myeloma cells using all-trans retinoic acid in a mouse model. (2001) (4)
- Lack of High-Dose Radiation Mediated Prostate Cancer Promotion and Low-Dose Radiation Adaptive Response in the TRAMP Mouse Model (2013) (4)
- DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo (2019) (4)
- Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression (2021) (4)
- Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy (2021) (4)
- Erratum to “Dose-dependent increase or decrease of somatic intrachromosomal recombination produced by etoposide” ☆: [Mutat. Res. 500 (2002) 117–124] (2002) (3)
- Temporal Responses to X-Radiation Exposure in Spleen in the pKZ1 Mouse Recombination Assay (2016) (3)
- Detecting Monoclonal Immunoglobulin andT-Cell Receptor Gene Rearrangements in B- andT-Cell Malignancies by Polymerase Chain Reaction. (2001) (3)
- Effect of age on the repertoire of cytotoxic memory (CD8+CD45RO+) T cells in peripheral blood: the use of rearranged T cell receptor gamma genes as clonal markers. (2006) (3)
- The ups and downs of low dose ionising radiobiology research (2016) (3)
- The use of marsupial x eutherian somatic cell hybrids to study marsupial cell surface antigens. (1978) (2)
- Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose (2009) (2)
- Provisional mapping of the gene for a cell surface marker, GA-1, in the red-necked wallaby Macropus rufogriseus. (1985) (2)
- 12. Molecular tools for diagnosis of synovial sarcomas: correlation of RT-PCR and fish on paraffin embedded material (2010) (2)
- Environmental health criteria for transgenic animal mutagenicity assays (2006) (1)
- The benefits of low dose radiation and the hazards of the media (2012) (1)
- Improved Measurement of Minimal Residual Disease (MRD). (2006) (1)
- Parthenolide as a selective radiosensitiser in the treatment and prevention of prostate cancer. (2013) (1)
- Radiation Research Journals Need to Stipulate Minimal Dosimetry Requirements for Publishing Research Using X-Radiation Exposures (2022) (1)
- Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro (2003) (1)
- The ups and downs of low dose ionising radiobiology research (2016) (0)
- Importance o f M inimal R esidual D isease T esting D uring t he Second Y ear o f T herapy f or C hildren W ith A cute Lymphoblastic L eukemia (2003) (0)
- Abstract 1161: Dimethylaminoparthenolide (DMAPT), an oral nuclear factor kappa B inhibitor (NFκB), enhances radiation therapy and enhances epidermal growth factor tyrosine kinase inhibitor (EGFR TKI) activity (2017) (0)
- The Repertoire of Gene Rearrangements in Acute Lymphoblastic Leukemia. (2005) (0)
- Abstract 1062: The combination of metformin and valproic acid induces synergistic apoptosis of prostate cancer cells via p53 activation and the intrinsic pathway (2017) (0)
- A rapid method for the detection of monoclonality in B cell lymphoma in lymph node aspirates using the polymerase chain reaction. (1992) (0)
- Effect of c-myc over-expression and loss of msh-2 expression on somatic intrachromosomal recombination (2001) (0)
- False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models (2013) (0)
- Characterisation of an adaptive response in pKZ1 mice after exposure to X-radiation (2003) (0)
- Preface. The relevance of the LNT (linear no-threshold) model of risk-assessment. (2007) (0)
- Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent (2014) (0)
- Detection of monoclonal immunoglobulin and T cell receptor gene rearrangements – the UPS and downs of fragment analysis (2011) (0)
- Lack of a low-dose radiation adaptive response on prostate cancer progression in the TRAMP model (2013) (0)
- Genes associated with cancer can affect somatic intrachromosomal recombination early in carcinogenesis (2003) (0)
- COMBINATION OF METFORMIN AND SODIUM VALPROATE FOR PROSTATE CANCER: A RAPID APPROACH FROM BENCH TO CLINICAL TRIAL.: MP83‐08 (2017) (0)
- Myeloma stem cells in autografting in multiple myeloma. (1996) (0)
- Molecular Biology Techniques in Malignant Lymphoma (1992) (0)
- Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide (2018) (0)
- Corneal Endothelium Ovine IL-12-p40 but Not IL-4 to Donor Survival by Transfer of the Gene Encoding Prolongation of Sheep Corneal Allograft (2005) (0)
- Abstract LB-233: Combination of metformin and valproic acid in personalized prostate cancer treatment: the role of p53 and androgen receptor signaling (2016) (0)
- Cross-reaction of a monoclonal antibody with fibroblasts from marsupials of the Macropodidae and Tarsipedidae families. (1985) (0)
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Pam Sykes is affiliated with the following schools: