Paola Picotti
#129,660
Most Influential Person Now
Italian biophysicist and molecular biologist
Paola Picotti's AcademicInfluence.com Rankings
Paola Picottiphysics Degrees
Physics
#8707
World Rank
#10985
Historical Rank
Biophysics
#394
World Rank
#406
Historical Rank
Paola Picottibiology Degrees
Biology
#10143
World Rank
#13443
Historical Rank
Molecular Biology
#2486
World Rank
#2525
Historical Rank
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Physics Biology
Paola Picotti's Degrees
- PhD Biophysics University of Padua
- Masters Physics University of Padua
Why Is Paola Picotti Influential?
(Suggest an Edit or Addition)According to Wikipedia, Paola Picotti is an Italian biologist who is Professor for Molecular Systems Biology at ETH Zürich. She is Deputy Head of the Institute for Molecular Systems Biology. Her research investigates how the conformational changes of proteins impact cellular networks. She was awarded the 2020 ETH Zürich Rössler Prize and the 2019 EMBO Gold Medal.
Paola Picotti's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Selected reaction monitoring for quantitative proteomics: a tutorial (2008) (1348)
- Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions (2012) (1155)
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016) (855)
- Full Dynamic Range Proteome Analysis of S. cerevisiae by Targeted Proteomics (2009) (780)
- High-throughput generation of selected reaction-monitoring assays for proteins and proteomes (2010) (468)
- mProphet: automated data processing and statistical validation for large-scale SRM experiments (2011) (448)
- Probing protein structure by limited proteolysis. (2004) (441)
- Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast (2010) (302)
- A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis (2013) (297)
- Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability (2017) (270)
- Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome (2016) (264)
- A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication (2018) (258)
- Global analysis of protein structural changes in complex proteomes (2014) (241)
- Host Cell Entry of Respiratory Syncytial Virus Involves Macropinocytosis Followed by Proteolytic Activation of the F Protein (2013) (229)
- A database of mass spectrometric assays for the yeast proteome (2008) (216)
- PhosphoPep—a database of protein phosphorylation sites in model organisms (2008) (215)
- The Implications of Proteolytic Background for Shotgun Proteomics*S (2007) (200)
- Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. (2014) (196)
- Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (170)
- Perspectives of targeted mass spectrometry for protein biomarker verification. (2009) (166)
- Increased Selectivity, Analytical Precision, and Throughput in Targeted Proteomics (2010) (160)
- Regulation of yeast central metabolism by enzyme phosphorylation (2012) (153)
- Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity (2010) (153)
- Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer (2011) (149)
- Protein Significance Analysis in Selected Reaction Monitoring (SRM) Measurements* (2011) (146)
- Proteomics meets the scientific method (2013) (137)
- Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration (2014) (122)
- Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics (2011) (116)
- TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates (2018) (115)
- Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress (2017) (113)
- Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry (2017) (111)
- Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast (2013) (110)
- Calcineurin determines toxic versus beneficial responses to α-synuclein (2014) (91)
- High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds (2018) (86)
- A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans (2010) (84)
- Mitotic redistribution of the mitochondrial network by Miro and Cenp-F (2015) (76)
- Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins (2017) (75)
- ATAQS: A computational software tool for high throughput transition optimization and validation for selected reaction monitoring mass spectrometry (2011) (70)
- Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast (2010) (68)
- A sentinel protein assay for simultaneously quantifying cellular processes (2014) (67)
- Amyloid fibril formation and disaggregation of fragment 1-29 of apomyoglobin: insights into the effect of pH on protein fibrillogenesis. (2007) (64)
- Differential glucose repression in common yeast strains in response to HXK2 deletion. (2010) (62)
- The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation (2018) (57)
- Proteomics beyond large-scale protein expression analysis. (2015) (56)
- Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ (2020) (53)
- Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles* (2016) (48)
- Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export (2012) (48)
- Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides (2018) (48)
- A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes (2020) (45)
- C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. (2009) (44)
- Modulation of the structural integrity of helix F in apomyoglobin by single amino acid replacements (2004) (38)
- Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis (2019) (38)
- Spectronaut A fast and efficient algorithm for MRM-like processing of data independent acquisition (SWATH-MS) data (2012) (37)
- Systematic measurement of transcription factor-DNA interactions by targeted mass spectrometry identifies candidate gene regulatory proteins (2013) (31)
- The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress (2016) (29)
- Functional and stoichiometric analysis of subunit e in bovine heart mitochondrial F0F1ATP synthase (2008) (27)
- Systematic detection of functional proteoform groups from bottom-up proteomic datasets (2020) (26)
- Mass spectrometry analysis of the structural proteome. (2019) (26)
- Biomarker validation in blood specimens by selected reaction monitoring mass spectrometry of N-glycosites. (2011) (25)
- FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome (2017) (24)
- A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology (2019) (22)
- Phosphorylation of nuclear Tau is modulated by distinct cellular pathways (2018) (22)
- USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit (2020) (22)
- RIP-chip-SRM—a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans (2012) (21)
- Proteomic analysis of F1F0-ATP synthase super-assembly in mitochondria of cardiomyoblasts undergoing differentiation to the cardiac lineage. (2013) (20)
- Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance (2020) (20)
- Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase (2016) (20)
- Unusual stability of human neuroglobin at low pH – molecular mechanisms and biological significance (2009) (18)
- Deciphering the signaling network of breast cancer improves drug sensitivity prediction. (2021) (15)
- Reproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoring. (2013) (15)
- Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly (2021) (15)
- Combining CRISPRi and metabolomics for functional annotation of compound libraries (2022) (15)
- IPM: An integrated protein model for false discovery rate estimation and identification in high-throughput proteomics. (2011) (14)
- Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS). (2020) (13)
- Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity (2019) (12)
- Selected Reaction Monitoring to Measure Proteins of Interest in Complex Samples: A Practical Guide. (2016) (12)
- Systems NMR: single-sample quantification of RNA, proteins, and metabolites for biomolecular network analysis (2019) (11)
- Nicked apomyoglobin: a noncovalent complex of two polypeptide fragments comprising the entire protein chain. (2004) (11)
- High-performance metabolic marker assessment in breast cancer tissue by mass spectrometry (2011) (11)
- Quantitative proteomics of model organisms (2017) (10)
- Conformational stability of neuroglobin helix F – possible effects on the folding pathway within the globin family (2009) (9)
- Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010. (2011) (9)
- Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes. (2011) (9)
- protti: an R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data (2021) (7)
- reaction-monitoring assays for proteins and proteomes (2012) (6)
- Voices in methods development (2019) (6)
- Phosphoproteomics takes it easy (2015) (6)
- Structure of the connexin-43 gap junction channel reveals 1 a closed sieve-like molecular gate (2022) (5)
- Biology/Disease-Driven Initiative on Protein-Aggregation Diseases of the Human Proteome Project: Goals and Progress to Date. (2018) (5)
- Global, in situ analysis of the structural proteome in individuals with Parkinson’s disease to identify a new class of biomarker (2022) (5)
- Corrigendum: Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase (2016) (4)
- LiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes (2019) (4)
- Voices of biotech (2016) (4)
- A Complete Mass-spectrometric Map of a Eukaryotic Proteome. (2013) (3)
- Limited Proteolysis-Mass Spectrometry to Identify Metabolite-Protein Interactions. (2023) (3)
- Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications (2022) (3)
- Systematic identification of structure-specific protein–protein interactions (2023) (2)
- mProphet : A general and flexible data model and algorithm for automated SRM data processing and statistical error estimation (2010) (2)
- Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1) (2020) (2)
- A natural variant of the sole pyruvate kinase of fission yeast lowers glycolytic flux triggering increased respiration and oxidative-stress resistance but decreased growth (2019) (2)
- Erratum: From promising to practical: tools to study networks of neurons (2010) (2)
- Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction (2020) (2)
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases (2021) (2)
- Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity (2023) (1)
- Calreticulin mutations affect its chaperone function and perturb the glycoproteome. (2022) (1)
- Author response: USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit (2020) (1)
- Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis (2019) (1)
- Phosphorylation of nuclear Tau is modulated by distinct cellular pathways (2018) (1)
- Publisher Correction: Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis (2019) (1)
- Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly (2021) (1)
- TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates (2018) (1)
- Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins. (2020) (1)
- Erratum: Phosphoproteomics takes it easy (2016) (1)
- Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT) (2022) (0)
- Epitope Tagging of Endogenous Proteins in Human Cells for Discovery of Novel Protein/Protein Interactions Quantitative Analysis of the Phosphoproteome of Resting and Activated Human Primary T Cells (2009) (0)
- Abstract 2755: Limited proteolysis coupled to mass spectrometry (LiP-MS), a novel drug target deconvolution strategy (2019) (0)
- Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. (2023) (0)
- Resource Human SRMAtlas : A Resource of Targeted Assays to Quantify the Complete Human Proteome Graphical Abstract Highlights (2016) (0)
- The ASC inflammasome adapter controls the severity of inflammation-related AA amyloidosis (2023) (0)
- Structure of the connexin-43 gap junction channel in a putative closed state (2023) (0)
- Modulation of limited proteolysis of apomyoglobin by amino acid replacements (2003) (0)
- Environmental Signals Act as a Driving Force for Metabolic and Defense Responses in the Antarctic Plant Colobanthus quitensis (2022) (0)
- terminal complement complex and may exert anti-inflammatory function C7 is expressed on endothelial cells as a trap for the assembling (2009) (0)
- Mapping the protein-protein interactions of Drosophila melanogaster (2009) (0)
- Author response: The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation (2018) (0)
- Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels (2023) (0)
- The PeptideAtlas as a tool for targeted proteomics (2008) (0)
- Effect of genetic background on the unicellular-to-multicellular epigenetic transition in natural yeast (2015) (0)
- System-level insights into plant commensal bacteria reveal molecular adaptation strategies towards colonization of the phyllosphere (2022) (0)
- Improved support for targeted proteomics workflows in PeptideAtlas (2009) (0)
- Large-scale changes of molecular network states explain complex traits (2022) (0)
- Monitoring protein structural changes on a proteome-wide scale (2017) (0)
- Structural basis of activation and inhibition of the Ca2+/calmodulin-sensitive adenylyl cyclase 8 (2023) (0)
- Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly (2021) (0)
- Selected Reaction Monitoring : A tool for quantifying proteins in biology and biomedicine (2012) (0)
- Author Correction: Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications. (2023) (0)
- Co-transcriptional quantification of RNA synthesis, RNA folding and RNA-protein interactions by "Systems NMR" approach. (2019) (0)
- Publisher Correction: Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis (2019) (0)
- ATAQS Computational Software Tool for High Throughput Transition Optimization and Validation for SRM (2009) (0)
- Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries (2022) (0)
- Abstract 21: LiP-MS, a machine learning-based chemoproteomic approach to identify drug targets in complex proteomes (2021) (0)
- Abstract C015: Limited proteolysis coupled to mass spectrometry (LiP-Quant), a novel drug target deconvolution strategy (2019) (0)
- Single cell signaling in breast cancer DREAM Challenge 2019 (2020) (0)
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What Schools Are Affiliated With Paola Picotti?
Paola Picotti is affiliated with the following schools:
