Patricia Simpson
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British biologist
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Patricia Simpsonbiology Degrees
Biology
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Genetics
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Molecular Biology
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#2485
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Biology
Patricia Simpson's Degrees
- Bachelors Biology University of Oxford
- PhD Molecular Biology Imperial College London
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Why Is Patricia Simpson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Patricia "Pat" Simpson FRS is a distinguished British developmental biologist. Simpson was a professor of Comparative Biology at the University of Cambridge from 2003 to 2010, and was the University's Director of Research for the academic year 2010/2011. She is currently an Emeritus Professor of the Department of Zoology of the University of Cambridge, having previously been Professor of Comparative Embryology, and a Fellow of Newnham College. She was elected a Fellow of the Royal Society in 2000.
Patricia Simpson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The choice of cell fate in the epidermis of Drosophila (1991) (752)
- Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. (1996) (366)
- Maternal-Zygotic Gene Interactions during Formation of the Dorsoventral Pattern in Drosophila Embryos. (1983) (334)
- Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. (1990) (313)
- The LIN-12/Notch signaling pathway and its regulation. (1997) (303)
- Requirement for dynamin during Notch signaling in Drosophila neurogenesis. (1997) (295)
- Choosing a cell fate: a view from the Notch locus. (1991) (235)
- pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. (1993) (233)
- Differential mitotic rates and patterns of growth in compartments in the Drosophila wing. (1981) (214)
- Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch (1993) (197)
- Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. (1997) (191)
- Parameters of cell competition in the compartments of the wing disc of Drosophila. (1979) (178)
- Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. (1993) (158)
- A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila. (1996) (158)
- Notch signalling in development: on equivalence groups and asymmetric developmental potential. (1997) (152)
- u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. (1997) (148)
- An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. (1990) (145)
- Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila. (2000) (145)
- Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila. (1999) (141)
- The initiation of pupariation in Drosophila: dependence on growth of the imaginal discs. (1980) (130)
- Mutations and Chromosomal Rearrangements Affecting the Expression of Snail, a Gene Involved in Embryonic Patterning in DROSOPHILA MELANOGASTER. (1984) (126)
- The development and evolution of bristle patterns in Diptera. (1999) (111)
- Zebrafish narrowminded disrupts the transcription factor prdm1 and is required for neural crest and sensory neuron specification. (2005) (107)
- Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila. (1997) (91)
- How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. (2002) (90)
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snail and cactus loci. (1990) (85)
- Ecdysteroid levels and pupariation in drosophila melanogaster (1979) (80)
- Two or Four Bristles: Functional Evolution of an Enhancer of scute in Drosophilidae (2006) (80)
- Evolution of development in closely related species of flies and worms (2002) (69)
- Notch and the choice of cell fate in Drosophila neuroepithelium. (1990) (68)
- Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila. (1993) (67)
- Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster. (1993) (65)
- Stripes of positional homologies across the wing blade of Drosophila melanogaster (1988) (63)
- Evolution of early development of the nervous system: a comparison between arthropods (2005) (62)
- scabrous modifies epithelial cell adhesion and extends the range of lateral signalling during development of the spaced bristle pattern in Drosophila. (2001) (59)
- Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish. (2004) (59)
- A study of shaggy reveals spatial domains of expression of achaete-scute alleles on the thorax of Drosophila. (1989) (55)
- Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in Diptera. (2002) (53)
- Mutant Drosophila embryos in which all cells adopt a neural fate (1989) (49)
- Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera. (2000) (49)
- Regeneration and compartments in Drosophila. (1979) (49)
- The segment polarity gene costal-2 in Drosophila. I. The organization of both primary and secondary embryonic fields may be affected. (1987) (46)
- Notch signaling in development. (1997) (45)
- Cellular basis of the dynamic behavior of the imaginal thoracic discs during Drosophila metamorphosis. (2000) (45)
- scute expression in Calliphora vicina reveals an ancestral pattern of longitudinal stripes on the thorax of higher Diptera. (2002) (43)
- Isolation of temperature sensitive mutations blocking clone development inDrosophila melanogaster, and the effects of a temperature sensitive cell lethal mutation on pattern formation in imaginal discs (1975) (41)
- Evolution of cis-regulation of the proneural genes. (2003) (41)
- Proneural clusters: equivalence groups in the epithelium of Drosophila. (1990) (38)
- Evolution of the achaete-scute complex in insects: convergent duplication of proneural genes. (2009) (36)
- Mutual Exclusion of Sensory Bristles and Tendons on the Notum of Dipteran Flies (2004) (35)
- NF-κB/Rel-Mediated Regulation of the Neural Fate in Drosophila (2007) (35)
- Analysis of the compartments of the wing of Drosophila melanogaster mosaic for a temperature-sensitive mutation that reduces mitotic rate. (1976) (34)
- The expression of pannier and achaete-scute homologues in a mosquito suggests an ancient role of pannier as a selector gene in the regulation of the dorsal body pattern. (2002) (32)
- Introduction: Notch signalling and choice of cell fates in development. (1998) (31)
- Clonal analysis of two wing-scalloping mutants of Drosophila. (1981) (30)
- Transcriptional heterochrony of scute and changes in bristle pattern between two closely related species of blowfly. (2002) (30)
- The origin and evolution of stereotyped patterns of macrochaetes on the nota of cyclorraphous Diptera (2006) (30)
- A gradient of affinities for sensory bristles across the wing blade of Drosophila melanogaster (1988) (28)
- The segment polarity gene costal-2 in Drosophila. II. The origin of imaginal pattern duplications. (1987) (27)
- The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila. (2007) (27)
- Redundant mechanisms mediate bristle patterning on the Drosophila thorax (2008) (26)
- Drosophila development: A prepattern for sensory organs (1996) (26)
- An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian (2010) (22)
- achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila. (2005) (19)
- The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier (2012) (18)
- Growth and cell competition in Drosophila (1981) (16)
- Movement of bristle precursors contributes to the spacing pattern in Drosophila (2002) (15)
- Larval multidendrite neurons survive metamorphosis and participate in the formation of imaginal sensory axonal pathways in the notum of Drosophila. (2000) (14)
- A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute. (2005) (14)
- Delta, notch, and shaggy: elements of a lateral signaling pathway in Drosophila. (1992) (14)
- Flipping fruit-flies: a powerful new technique for generating Drosophila mosaics. (1993) (13)
- A dual role for the protein kinase shaggy in the repression of achaete-scute. (1993) (12)
- Evolution of cis-regulatory sequences in Drosophila. (2008) (12)
- A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous Diptera (2005) (11)
- Diversity of transposable elements and repeats in a 600 kb region of the fly Calliphora vicina (2013) (10)
- The control of growth in the imaginal discs of Drosophila. (1980) (9)
- Differences in sensory projections between macro- and microchaetes in Drosophilid flies. (2005) (9)
- A prepattern for sensory organs. Drosophila development. (1996) (9)
- The achaete‐scute complex in Diptera: patterns of noncoding sequence evolution (2015) (8)
- The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera☆ (2014) (8)
- A temperature sensitive mutation that reduces mitotic rate inDrosophila melanogaster (1976) (7)
- Faculty Opinions recommendation of Parasegmental organization of the spider embryo implies that the parasegment is an evolutionary conserved entity in arthropod embryogenesis. (2002) (3)
- Results and problems in cell differentiation, vol. 9. Genetic mosaics and cell differentiation: edited by W. J. Gehring, Springer-Verlag, Berlin, Heidelberg and New York, 1978. DM 98.00/US $53.90 (x + 315 pages) ISBN 3 540 08882 2 (1980) (3)
- Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera (2006) (3)
- Faculty Opinions recommendation of The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation. (2001) (2)
- A dual role for the protein kinase shaggy in the repression of achaete-scute. (1993) (1)
- 15-P026 The evolution of gene regulation in insects: A study on molecular repressors of bristle patterns in flies (2009) (1)
- Development and phylogeny of arthropods. (2006) (1)
- Diversity of transposable elements and repeats in a 600 kb region of the fly Calliphora vicina (2013) (1)
- Model systems for the study of development and patterning of the nervous system (1994) (1)
- [Role of the Notch receptors in intercellular communication]. (1996) (0)
- Faculty Opinions recommendation of Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. (2002) (0)
- Faculty Opinions recommendation of Coevolution in bicoid-dependent promoters and the inception of regulatory incompatibilities among species of higher Diptera. (2002) (0)
- Faculty Opinions recommendation of Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. (2002) (0)
- Faculty Opinions recommendation of Evolution of neural precursor selection: functional divergence of proneural proteins. (2004) (0)
- Faculty Opinions recommendation of Neurogenesis in the chilopod Lithobius forficatus suggests more similarities to chelicerates than to insects. (2004) (0)
- Faculty Opinions recommendation of Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. (2007) (0)
- Faculty Opinions recommendation of Early blastomere determines embryo proliferation and caste fate in a polyembryonic wasp. (2004) (0)
- Faculty Opinions recommendation of Localization of ecdysone receptor protein during colour pattern formation in wings of the butterfly Precis coenia (Lepidoptera: Nymphalidae) and co-expression with Distal-less protein. (2003) (0)
- Faculty Opinions recommendation of Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. (2006) (0)
- Faculty Opinions recommendation of Drosophila tufted is a gain-of-function allele of the proneural gene amos. (2003) (0)
- Faculty Opinions recommendation of A pair-rule gene circuit defines segments sequentially in the short-germ insect Tribolium castaneum. (2006) (0)
- Faculty Opinions recommendation of Regulatory changes underlying expression differences within and between Drosophila species. (2008) (0)
- Faculty Opinions recommendation of Hox Gene Loss during Dynamic Evolution of the Nematode Cluster. (2003) (0)
- Functional significance ofa family ofprotein kinases encoded attheshaggylocus inDrosophila (1993) (0)
- Faculty Opinions recommendation of Delta and Hairy establish a periodic prepattern that positions sensory bristles in Drosophila legs. (2006) (0)
- Faculty Opinions recommendation of A DNA transcription code for cell-specific gene activation by notch signaling. (2005) (0)
- Faculty Opinions recommendation of The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila. (2003) (0)
- OF SNAIL , A GENE INVOLVED IN EMBRYONIC PATTERNING IN DROSOPHZLA MELANOGASTER (2003) (0)
- Positive and Negative Regulators of Neural Fate Minireview (1995) (0)
- Faculty Opinions recommendation of Seven Wnt homologues in Drosophila: a case study of the developing tracheae. (2001) (0)
- Faculty Opinions recommendation of Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. (2008) (0)
- Rescuing Activity of scute Minigenes (2013) (0)
- Faculty Opinions recommendation of A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. (2003) (0)
- Faculty Opinions recommendation of Recruitment of the proneural gene scute to the Drosophila sex-determination pathway. (2004) (0)
- Faculty Opinions recommendation of Origins of bilateral symmetry: Hox and dpp expression in a sea anemone. (2004) (0)
- Faculty Opinions recommendation of The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila. (2003) (0)
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