Patrick Aebischer
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Patrick Aebischer's Degrees
- Doctorate Medicine University of Geneva
- PhD Neurosciences University of Geneva
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(Suggest an Edit or Addition)Patrick Aebischer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. (2000) (1251)
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents (2016) (534)
- A Combination of BDNF and NT-3 Promotes Supraspinal Axonal Regeneration into Schwann Cell Grafts in Adult Rat Thoracic Spinal Cord (1995) (496)
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer* (2012) (480)
- α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease (2002) (470)
- Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration (1992) (459)
- Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS (2005) (458)
- Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients (1996) (431)
- A versatile tool for conditional gene expression and knockdown (2006) (387)
- In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons. (2016) (386)
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions (2009) (378)
- Isolation of Multipotent Neural Precursors Residing in the Cortex of the Adult Human Brain (2001) (323)
- Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. (2004) (318)
- Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension (2000) (315)
- Lentiviral-mediated RNA interference. (2002) (313)
- GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS (2007) (304)
- Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. (2000) (304)
- GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap (2002) (288)
- GDNF delivery using human neural progenitor cells in a rat model of ALS. (2005) (270)
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions (2010) (261)
- Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2 (2001) (257)
- Regrowth of axons into the distal spinal cord through a Schwann‐cell‐seeded mini‐channel implanted into hemisected adult rat spinal cord (1999) (254)
- Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration (2014) (246)
- Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. (2008) (244)
- Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps (1989) (240)
- Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study. (2004) (239)
- alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. (2002) (226)
- The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans (2019) (223)
- Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration (2002) (222)
- Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length (2002) (221)
- Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease (1995) (221)
- Local Fas/APO‐1 (CD95) ligand‐mediated tumor cell killing in vivo (1995) (208)
- Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. (2008) (208)
- Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels. (2001) (203)
- Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy (2001) (203)
- Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF (2000) (201)
- Robots and Biological Systems: Towards a New Bionics? (2012) (195)
- Lentiviral Gene Transfer to the Nonhuman Primate Brain (1999) (194)
- Hydrogel-based three-dimensional matrix for neural cells. (1995) (194)
- Laminin oligopeptide derivatized agarose gels allow three‐dimensional neurite extension in vitro (1995) (192)
- Tmc gene therapy restores auditory function in deaf mice (2015) (192)
- Complete and Long-Term Rescue of Lesioned Adult Motoneurons by Lentiviral-Mediated Expression of Glial Cell Line-Derived Neurotrophic Factor in the Facial Nucleus (2000) (185)
- Electrically charged polymeric substrates enhance nerve fibre outgrowth in vitro. (1992) (180)
- The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis (1997) (179)
- Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. (2008) (179)
- Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line (1991) (178)
- Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates (2006) (177)
- Chitosan as a matrix for mammalian cell encapsulation. (1994) (176)
- Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells (1991) (176)
- Sniff nasal pressure: A sensitive respiratory test to assess progression of amyotrophic lateral sclerosis (1999) (175)
- Akt is altered in an animal model of Huntington's disease and in patients (2005) (174)
- Piezoelectric guidance channels enhance regeneration in the mouse sciatic nerve after axotomy (1987) (171)
- Polymer Encapsulated Cell Lines Genetically Engineered to Release Ciliary Neurotrophic Factor Can Slow Down Progressive Motor Neuronopathy in the Mouse (1995) (169)
- Glial cell line‐derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones (1994) (168)
- GDNF Reduces Drug-Induced Rotational Behavior after Medial Forebrain Bundle Transection by a Mechanism Not Involving Striatal Dopamine (1997) (168)
- Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. (2000) (166)
- Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease (2001) (162)
- Transplantation of neural tissue in polymer capsules (1988) (161)
- Channel-Mediated Lactate Release by K+-Stimulated Astrocytes (2015) (161)
- The functional characteristics of Schwann cells cultured from human peripheral nerve after transplantation into a gap within the rat sciatic nerve (1994) (160)
- Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo (2013) (160)
- Collagen- and laminin-containing gels impede peripheral nerve regeneration through semipermeable nerve guidance channels (1987) (157)
- Neuronal GDNF Expression in the Adult Rat Nervous System Identified By In Situ Hybridization (1997) (154)
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2 (2011) (152)
- Three-dimensional extracellular matrix engineering in the nervous system. (1998) (151)
- Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells (1994) (151)
- In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel. (1998) (151)
- Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease. (2007) (148)
- Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro (1996) (147)
- GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice (1996) (145)
- Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances (1993) (144)
- Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease (2004) (144)
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity (2012) (140)
- TRANSPLANTATION IN HUMANS OF ENCAPSULATED XENOGENEIC CELLS WITHOUT IMMUNOSUPPRESSION: A PRELIMINARY REPORT (1994) (139)
- Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. (2000) (139)
- Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II. (1995) (135)
- Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery (2009) (135)
- Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2. (2000) (134)
- Neurospheres modified to produce glial cell line‐derived neurotrophic factor increase the survival of transplanted dopamine neurons (2002) (129)
- Inhibition of Calcineurin by FK506 Protects against Polyglutamine-Huntingtin Toxicity through an Increase of Huntingtin Phosphorylation at S421 (2006) (128)
- Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice. (2008) (127)
- Transplantation of a Polymer-Encapsulated Cell Line Genetically Engineered to Release NGF (1993) (127)
- Implants of Polymer-Encapsulated Genetically Modified Cells Releasing Glial Cell Line-Derived Neurotrophic Factor Improve Survival, Growth, and Function of Fetal Dopaminergic Grafts (1998) (122)
- Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump (1988) (122)
- Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6 (2010) (120)
- Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease (2004) (120)
- An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats (1989) (119)
- Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function (2012) (117)
- Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. (2006) (117)
- Glial cell line‐derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat (2002) (117)
- The Krüppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis* (2007) (115)
- Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. (1996) (114)
- Immunoisolated Xenogeneic Chromaffin Cell Therapy for Chronic Pain: Initial Clinical Experience (1996) (114)
- Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels. (1991) (113)
- Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. (2002) (113)
- Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution. (1991) (112)
- Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. (2013) (111)
- Nerve Growth Factor- and Neurotrophin-3-Releasing Guidance Channels Promote Regeneration of the Transected Rat Dorsal Root (2001) (110)
- The morphology of regenerating peripheral nerves is modulated by the surface microgeometry of polymeric guidance channels (1990) (109)
- Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia (2001) (107)
- Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology (2015) (104)
- Selective neuronal cell attachment to a covalently patterned monoamine on fluorinated ethylene propylene films. (1993) (102)
- Parkinson's disease: gene therapies. (2012) (101)
- NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion (1990) (101)
- Polymer electret guidance channels enhance peripheral nerve regeneration in mice (1989) (99)
- Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry (2008) (94)
- Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons (2004) (93)
- A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension. (1997) (93)
- Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. (2003) (93)
- Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons (1998) (92)
- Peripheral nerve regeneration through blind-ended semipermeable guidance channels: effect of the molecular weight cutoff (1989) (92)
- Attenuation of 6‐OHDA‐induced neurotoxicity in glutathione peroxidase transgenic mice (1998) (88)
- Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain (1998) (87)
- Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts (1998) (86)
- Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. (2007) (86)
- Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease (2006) (83)
- Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment (2005) (82)
- Imaging brain amyloid deposition using grating-based differential phase contrast tomography (2012) (82)
- Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates (1994) (81)
- Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. (2007) (81)
- Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts. (1996) (78)
- Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy (2007) (77)
- Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats (1991) (76)
- Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease (2012) (74)
- Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina (2003) (74)
- Evaluation of an Intrathecal Immune Response in Amyotrophic Lateral Sclerosis Patients Implanted with Encapsulated Genetically Engineered Xenogeneic Cells (2000) (74)
- Implication of the JNK pathway in a rat model of Huntington's disease (2009) (73)
- Human gene marker/therapy clinical protocols. (1996) (73)
- Recombinant proteins for neurodegenerative diseases: the delivery issue (2001) (73)
- Review: Tissue engineering in the nervous system (1994) (72)
- Viral-based modelling and correction of neurodegenerative diseases by RNA interference (2006) (72)
- GDNF-Secreting Human Neural Progenitor Cells Increase Tyrosine Hydroxylase and VMAT2 Expression in MPTP-Treated Cynomolgus Monkeys (2008) (72)
- Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. (2009) (71)
- Polymer-Encapsulated PC12 Cells: Long-Term Survival and Associated Reduction in Lesion-Induced Rotational Behavior (1992) (71)
- Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice (2004) (70)
- Seizure Suppression in Kindled Rats by Intraventricular Grafting of an Adenosine Releasing Synthetic Polymer (1999) (69)
- Sustained delivery of GDNF: towards a treatment for Parkinson’s disease (2001) (69)
- Peripheral nerve regeneration is impeded by interleukin‐1 receptor antagonist released from a polymeric guidance channel (1991) (69)
- Transplantation of Encapsulated Bovine Chromaffin Cells in the Sheep Subarachnoid Space: A Preclinical Study for the Treatment of Cancer Pain (1994) (69)
- The bioartificial kidney: progress towards an ultrafiltration device with renal epithelial cells processing. (1987) (68)
- Lentivirus-mediated expression of glutathione peroxidase: Neuroprotection in murine models of Parkinson's disease (2006) (67)
- Polymer encapsulated neurotransmitter secreting cells. Potential treatment for Parkinson's disease. (1992) (65)
- Brain tissue reaction to permselective polymer capsules. (1989) (63)
- Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice. (2011) (63)
- The activity of pars compacta neurons of the monkey substantia nigra in relation to motor activation (1983) (63)
- Photoimmobilization of a bioactive laminin fragment and pattern-guided selective neuronal cell attachment. (1995) (62)
- Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death (2010) (60)
- SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice (2015) (60)
- Use of viral vectors to create animal models for Parkinson's disease (2012) (60)
- Application of Teflon-AF thin films for bio-patterning of neural cell adhesion. (1998) (60)
- Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease (2009) (59)
- AAV‐mediated expression of wild‐type and ALS‐linked mutant VAPB selectively triggers death of motoneurons through a Ca2+‐dependent ER‐associated pathway (2010) (58)
- Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy (1998) (58)
- Monolayer chemical lithography and characterization of fluoropolymer films (1992) (58)
- Seizure Suppression by Adenosine‐releasing Cells Is Independent of Seizure Frequency (2002) (58)
- A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. (2014) (57)
- Transplantation of polymer encapsulated neurotransmitter secreting cells: effect of the encapsulation technique. (1991) (57)
- Parkin functionally interacts with PGC‐1&agr; to preserve mitochondria and protect dopaminergic neurons (2017) (57)
- Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS. (2013) (57)
- Patterned neuronal attachment and outgrowth on surface modified, electrically charged fluoropolymer substrates. (1993) (56)
- Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. (2011) (56)
- Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors. (2003) (55)
- Bovine serum albumin conformation on methyl and amine functionalized surfaces compared by scanning force microscopy. (1995) (55)
- A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. (2014) (54)
- Improvement of mouse β-thalassemia upon erythropoietin delivery by encapsulated myoblasts (1999) (53)
- Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1G93A transgenic mice (2004) (53)
- CA150 Expression Delays Striatal Cell Death in Overexpression and Knock-In Conditions for Mutant Huntingtin Neurotoxicity (2006) (52)
- Magnitude and polarity of a fluoroethylene propylene electret substrate charge influences neurite outgrowth in vitro. (1993) (52)
- Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord. (2014) (51)
- Delta‐like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons (2008) (49)
- Tissue reaction to intraperitoneal polymer implants: species difference and effects of corticoid and doxorubicin. (1989) (48)
- The Astrocyte Inhibition of Peripheral Nerve Regeneration Is Reversed by Schwann Cells (1994) (47)
- Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF. (1996) (46)
- Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF (2009) (45)
- Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. (2013) (45)
- Neuroprotective effect of interleukin‐6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome (2001) (44)
- Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease. (2012) (43)
- Lentiviruses as vectors for CNS diseases. (2002) (43)
- Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non‐human primate after overexpression of GDNF (2009) (43)
- Synthesis and characterization of fluoropolymeric substrata with immobilized minimal peptide sequences for cell adhesion studies. I. (1995) (43)
- A bioartificial parathyroid. (1986) (42)
- Tissue reaction to fabrics coated with turbostratic carbon: subcutaneous versus vascular implants. (1988) (42)
- Long‐term glial cell line‐derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production (2005) (40)
- Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease (2015) (40)
- Renal epithelial-cell-controlled solute transport across permeable membranes as the foundation for a bioartificial kidney. (1989) (39)
- Cell therapy using encapsulated cells producing endostatin. (2003) (38)
- Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts. (2002) (38)
- Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery. (2003) (38)
- Fetal Spinal Cord Tissue in Mini-Guidance Channels Promotes Longitudinal Axonal Growth after Grafting into Hemisected Adult Rat Spinal Cords (1999) (38)
- Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions. (2002) (37)
- Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor (2005) (37)
- Experience with fully bioresorbable aortic grafts in the dog. (1988) (36)
- An in vivo ultrahigh field 14.1 T 1H‐MRS study on 6‐OHDA and α‐synuclein‐based rat models of Parkinson's disease: GABA as an early disease marker (2012) (36)
- Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. (2002) (35)
- Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent (2016) (35)
- Encapsulated cells as therapy. (1999) (33)
- Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience. (1996) (33)
- Conditional gene expression and knockdown using lentivirus vectors encoding shRNA. (2008) (33)
- Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions. (2004) (32)
- The activity of pars compacta neurons of the monkey substantia nigra is depressed by apomorphine (1984) (32)
- Cellular control of membrane permeability. Implications for a bioartificial renal tubule. (1988) (32)
- Structural Changes of Bovine Serum Albumin upon Adsorption to Modified Fluoropolymer Substrates Used for Neural Cell Attachment Studies (1995) (31)
- A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies. (2016) (30)
- Renal epithelial cells grown on semipermeable hollow fibers as a potential ultrafiltrate processor. (1987) (30)
- Efficient Gene Transfer and Expression of Biologically Active Glial Cell Line‐Derived Neurotrophic Factor in Rat Motoneurons Transduced with Lentiviral Vectors (2000) (30)
- Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices (2004) (30)
- Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity (2017) (29)
- Boosting Higher Education in Africa through Shared Massive Open Online Courses (MOOCs) (2014) (28)
- Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications (2009) (28)
- Mast cells and tissue reaction to intraperitoneally implanted polymer capsules. (1991) (27)
- Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults (2022) (27)
- The problems of delivering neuroactive molecules to the CNS. (1996) (27)
- Regeneration of Transected Sciatic Nerves Through Semi‐Permeable Nerve Guidance Channels: Effects of Extracellular Matrix Protein Additives (1986) (27)
- Polymer encapsulated dopaminergic cell lines as "alternative neural grafts". (1990) (27)
- Insulin‐like growth factor‐1 and neurotrophin‐3 gene therapy prevents motor decline in an X‐linked adrenoleukodystrophy mouse model (2009) (27)
- Substance P containing polymer implants protect against striatal excitotoxicity (1993) (26)
- Transplant of polymer-encapsulated cells genetically engineered to release nerve growth factor allows a normal functional development of the visual cortex in dark-reared rats. (1997) (25)
- Seizure suppression in kindling epilepsy by intracerebral implants of GABA-but not by noradrenalinereleasing polymer matrices (1994) (24)
- Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts (2007) (24)
- Treatment of amyotrophic lateral sclerosis using a gene therapy approach. (1995) (23)
- The Dawn of Biotechnology in Artificial Organs (1995) (22)
- An in vivo culture system for human embryos using an encapsulation technology: a pilot study (2008) (21)
- Encapsulated thymic epithelial cells as a potential treatment for immunodeficiencies. (1988) (21)
- Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults (2022) (21)
- Optimization of human erythropoietin secretion from MLV‐infected human primary fibroblasts used for encapsulated cell therapy (2003) (20)
- Encapsulated neural transplants. (2000) (20)
- Cellular xenotransplantation (1999) (19)
- Allogeneic β-islet cells correct diabetes and resist immune rejection (2002) (19)
- Salivary glands and gene therapy: the mouth waters (2004) (19)
- Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. (2000) (19)
- Comparison of dorsal and ventral spinal root regeneration through semipermeable guidance channels (1991) (18)
- Repair of the blood-brain barrier following implantation of polymer capsules (1991) (17)
- Allogeneic beta-islet cells correct diabetes and resist immune rejection. (2002) (16)
- Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi. (2009) (16)
- Viral vectors, animal models and new therapies for Parkinson's disease. (2008) (16)
- Microencapsulated Bovine Chromaffin Cells In Vitro: Effect of Density and Coseeding with a NGF-Releasing Cell Line (1992) (16)
- Surface Characterization of a Biochip Prototype for Cell-Based Biosensor Applications (1999) (16)
- Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis (2019) (15)
- Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population (2021) (15)
- Growth of tumour cell lines in polymer capsules: ultrastructure of encapsulated PC12 cells (1992) (15)
- Tissue Engineering in the Nervous System (1999) (14)
- Perforated silicon dices with integrated nerve guidance channels for interfacing peripheral nerves (1995) (14)
- Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation. (2014) (14)
- A self-immunomodulating myoblast cell line for erythropoietin delivery (2001) (14)
- Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease (2017) (13)
- Production of Marked Prolongation of Islet Xenograft Survival (Rat to Mouse) by Local Release of Mouse and Rat Antilymphocyte Sera at Transplant Site (1991) (13)
- The use of a semi-permeable tube as a guidance channel for a transected rabbit optic nerve. (1988) (13)
- Presence of Gal‐α1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology (2003) (12)
- Gene transfer techniques for the delivery of GDNF in Parkinson's disease. (2000) (12)
- Lentiviral-mediated gene transfer to model triplet repeat disorders. (2004) (12)
- Treating Parkinson's disease with lesions of the subthalamic nucleus. (1991) (12)
- Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps. (1996) (11)
- Piezoelectric nerve guidance channels enhance peripheral nerve regeneration. (1987) (11)
- INDUCING HOST ACCEPTANCE TO ENCAPSULATED XENOGENEIC MYOBLASTS (2001) (10)
- In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices. (2004) (10)
- Advances and Technical Standards in Neurosurgery (1980) (10)
- Playng defense against Lou Gehrig's disease. (2007) (10)
- CHAPTER 56 – NERVE REGENERATION (2000) (10)
- ALS, IGF-1 and gene therapy: ‘it's never too late to mend’ (2004) (10)
- Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model (2013) (9)
- Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors. (2000) (9)
- Tissue-Engineering approaches for central and peripheral nervous-system regeneration. (1996) (9)
- Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants. (2006) (9)
- The Encoding of Motor Acts by the Substantia Nigra (1983) (9)
- Chronic Delivery of Antibody Fragments Using Immunoisolated Cell Implants as a Passive Vaccination Tool (2011) (7)
- Viral vector-mediated gene therapy for Parkinson's disease (2001) (7)
- Coated bioresorbable mesh as vascular graft material. (1985) (7)
- Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior. (1992) (6)
- Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases. (1995) (6)
- Control of water flux in a bioartificial kidney. (1989) (6)
- Treatment of diseases of the central nervous system using encapsulated cells. (1999) (6)
- ORALLY ADMINISTERED UROLITHIN A IS SAFE AND MODULATES MUSCLE AND MITOCHONDRIAL BIOMARKERS IN ELDERLY (2017) (6)
- The Role Of Materials In Designing Nerve Guidance Channels And Chronic Neural Interfaces (1993) (5)
- Transport Functions in a Bioartificial Kidney under Uremic Conditions (1990) (5)
- Continuous delivery of erythropoietin in mice using encapsulated genetically engineered cells lines (1996) (5)
- Philanthropy: The price of charity (2012) (5)
- Astrocyte‐targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast‐fatigable motor units in a mouse model of amyotrophic lateral sclerosis (2022) (4)
- Research policy: How to build science capacity (2012) (4)
- Gene therapy to the rescue in Parkinson's disease. Response from Kordower and Aebischer. (2001) (4)
- Neurotrophins BDNF and NT‐3 promote axonal re‐entry into the distal host spinal cord through Schwann cell‐seeded mini‐channels (2001) (4)
- A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease. (1998) (3)
- High-throughput, high-resolution X-ray phase contrast tomographic microscopy for visualisation of soft tissue (2009) (3)
- Biomaterials and Artificial Organs (2006) (3)
- Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman Primate (2009) (3)
- Positive electret substrates enhance neuroblastoma process outgrowth (1991) (3)
- A biomimetic materials approach towards the development of a neural cell-based biosensor (1996) (3)
- Bridging a Transected Rat Optic Nerve with a Semipermeable Guidance Channel (1987) (3)
- Lentiviral delivery of GDNF in aged MPTP-treated rhesus monkeys: Correlations between functional measures (2006) (2)
- An intraperitoneal receptacle for macroencapsulated endocrine tissue. (1986) (2)
- Gene therapy approaches for Parkinson's disease (2003) (2)
- Tissue developed around bioresorbable implants. Load-bearing versus histology. (1986) (2)
- Polymer Encapsulated Xenogeneic Cell Lines: A Novel Approach for Gene Therapy (1997) (2)
- Effects of attachment substrates on the growth and differentiation of LLC-PK1 cells (1990) (2)
- Viral vectors as a tool to model and treat Parkinson's disease (2006) (2)
- Promoters as a Tool to Target Gene Expression into the Mouse Retina Using Subretinal Injection of Self-Inactivating Lentiviral Vectors (2003) (2)
- Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET (2011) (2)
- Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain (2013) (1)
- 606. Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis (2016) (1)
- Pattern of Activity of Viral and Housekeeping Gene Using Self-inactivating Lentivirus Vector Delivery into the Mouse Retina (2002) (1)
- Cellular implants: pioneers in xenotransplantation? (2003) (1)
- Encapsulated cell implants as a novel treatment for Parkinson's disease. (2001) (1)
- ON THE WAY TO BIOARTIFICIAL ORGANS (1988) (1)
- TRANSLATING UROLITHIN A BENEFITS ON MUSCLE MITOCHONDRIA TO HUMANS (2018) (1)
- Expression of a miRNA targeting mutated SOD1 in astrocytes induces motoneuron plasticity and improves neuromuscular function in ALS mice (2021) (1)
- Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease (2011) (1)
- Perineuronal net digestionwith chondroitinase restores memory inmice with tau pathology (2014) (1)
- Strategies for Administering Neurotrophic Factors to the Central Nervous System (1999) (1)
- Development Of A Cell Encapsulation Approach For Human Anti-Tumor Immunotherapy (2008) (1)
- Effective Delivery of the Neuroprotectant to the Brain (2010) (1)
- Advances and Technical Standards in Neurosurgery (2002) (0)
- Viral vectors: a potent approach to generate genetic models of Parkinson"s disease (2008) (0)
- Nerve Repair: Biomaterials (2014) (0)
- Development of gene therapy for the treatment of neurodegenerative diseases (1996) (0)
- Editorial Board (2004) (0)
- Survival of human neural stem cells (HNSCs) expressing GDNF in mptp-treated rhesus monkeys (2006) (0)
- Microsoft Word-Fauvet and Lashuel et al JBC main text corrected abstract 07Feb12.docx (2012) (0)
- 953. Progressive and Selective Striatal Degeneration in Primary Neuronal Cultures Using Lentiviral Vector Coding Mutant Huntingtin Fragment (2005) (0)
- Encapsulation as a strategy for cell xenotransplantation (2002) (0)
- Analysis of alpha-synuclein aggregation and associated pathologies in a cellular model of multiple system atrophy (2005) (0)
- Feasibility of gene therapy for the treatment of neuropathic pain: downregulation of GTP cyclohydrolase 1 expression via RNA interference (2008) (0)
- In vivo administration of neurotransmitters encapsulated by implanted cells. (1988) (0)
- In vivo analysis of integrin transport in adult CNS axons (2010) (0)
- Restoration of arylsulphatase A activity in murine metachromatic leukodistrophy oligodendrocytes by retroviral vector-mediated gene transfer (2000) (0)
- F-ACTIN NANO-ARCHITECTURE IS COMPROMISED IN DENDRITIC SPINES OF PRIMARY NEURONS FROM APP/PS1 MICE AND IS RESTORED BY GLUTAREDOXIN-1 (2017) (0)
- DEVELOPPEMENT D'UN PANCREAS BIOARTIFICIEL (1998) (0)
- Editorial Board (2004) (0)
- IC-P-114 LONGITUDINAL ADC CHANGES IN ALZHEIMER’S DISEASE IN A MULTICENTER CLINICALTRIAL SETTING (2019) (0)
- neutral implant system (1992) (0)
- 229 EFFICACY AND SPECIFICITY OF RECOMBINANT ADENO‐ASSOCIATED VIRUS SEROTYPE 6 MEDIATED GENE TRANSFER TO DRG NEURONS THROUGH DIFFERENT ROUTES OF DELIVERY (2009) (0)
- Transplantation of an encapsulated genetically engineered cell line releasing ciliary neurotrophic factor in LOU gehrig disease (1996) (0)
- NEURODEGENERATIVE DISORDERS: GENE ThERAPy ON ClINICAl TRIAl (2010) (0)
- High-resolution amyloid plaque imaging using differential phase contrast x-ray tomography (2011) (0)
- BIOARTIFICIAL ORGANS-WHAT HAVE WE LEARNED FROM THE FIRST CLINICAL TRIAL? (1995) (0)
- Neurotrophic Factors, Encapsulated Cells, and ALS (1999) (0)
- Behavioral and neuropathological characterization of a viral-based model of amyloid pathology (2011) (0)
- Long-term delivery of erythropoietin in DBA/2J mice by immunoisolated genetically modified mouse C3H fibroblasts (1996) (0)
- Preventive anti-aß passive immunization using a subcutaneous cellular implant lowers brain amyloid burden and tau pathology (2015) (0)
- In vivo administration of neurotransmitters by implanted encapsulated cells. (1988) (0)
- Amyotrophic Lateral Sclerosis as a Target Disease for Gene Therapy Using the Encapsulation Technology (1995) (0)
- Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain (2013) (0)
- Editorial Board (2011) (0)
- Brief Report Lentiviral-Mediated RNA Interference (2002) (0)
- Neuroinhibitory compounds released from implantable devices (1993) (0)
- The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans (2019) (0)
- GENE TRANSFER APPROACHES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES (1999) (0)
- A Gene Therapy Approach for the Treatment of ALS (1998) (0)
- 1999 Referees (1999) (0)
- Implantable, biocompatible immune insulator-carrier substance to deliver selected, therapeutic products (1992) (0)
- Neurochemical profiling of two rodent Parkinson ’ s disease models : an in vivo MR spectroscopy study (2010) (0)
- Alpha-Synuclein Animal Models (2010) (0)
- SLS Symposium on X-ray Imaging for Medicine (2011) (0)
- Neuropathic pain: Gene therapy as a tool to transduce nociceptors (2008) (0)
- Megatrends: Rise and Fall of Megatrends in Science ; Proceedings (2002) (0)
- The chitosan matrices for the encapsulated cells (1993) (0)
- The potential of gene therapy for motor neuron diseases (2006) (0)
- Modelling Alzheimer's disease through Adeno-Associated Virus (AAV) vector gene delivery in the mouse brain (2011) (0)
- Rescue of Motoneurons from Axotomy-Induced Cell Death by Polymer Encapsulated Cells Genetically Engineered to Release CNTF (1996) (0)
- Article Commentary: Highlights of the Cell Transplantation Meeting at Montreux, March 1999 (1999) (0)
- Contents, Vol 36, 1996 (1990) (0)
- In vivo secretion of active factors by co-cultured cell implants (1992) (0)
- Using chimeric IL6-IL6R in huntington disease (2001) (0)
- The Cell Transplant Society Fourth International Congress: Welcome Address (1999) (0)
- Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity (2017) (0)
- From gene to gene therapy and pharmacotherapy, via transgenic animals (2007) (0)
- Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications (cid:1) (2009) (0)
- Subject Index Vol. 36, 1996 (1996) (0)
- Overexpression of tau in the mouse forebrain using adeno-associated virus (AAV) leads to tau hyperphosphorylation, formation of neurofibrillary tangles and neurodegeneration (2012) (0)
- Micro-encapsulation pharmaceutique (1996) (0)
- Lentiviral Delivery of Glial Cell Line-derived Neurotrophic Factor in Aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Rhesus Monkeys: 883 (2006) (0)
- Compositions and methods for a bioartificial artificial matrix (1995) (0)
- Use of IL-6R / IL-6 chimera for Huntington's disease (2001) (0)
- A method for preparing a cell culture medium for planting in the release of a neurotransmitter (1990) (0)
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What Schools Are Affiliated With Patrick Aebischer?
Patrick Aebischer is affiliated with the following schools:
