Patrick Cramer
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German biochemist
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Patrick Cramerbiology Degrees
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Molecular Biology
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Biochemistry
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Biology
Patrick Cramer's Degrees
- PhD Biochemistry University of Marburg
Why Is Patrick Cramer Influential?
(Suggest an Edit or Addition)According to Wikipedia, Patrick Cramer is a German chemist, structural biologist, and molecular systems biologist. In 2020, he was honoured to be an international member of the National Academy of Sciences. He became president of the Max Planck Society in June 2023.
Patrick Cramer's Published Works
Published Works
- RNA velocity of single cells (2018) (1934)
- Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution (2001) (1207)
- Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution (2001) (881)
- Architecture of RNA polymerase II and implications for the transcription mechanism. (2000) (613)
- Structure of replicating SARS-CoV-2 polymerase (2020) (529)
- Uniform transitions of the general RNA polymerase II transcription complex (2010) (467)
- Real-time cryo–EM data pre-processing with Warp (2018) (455)
- Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. (2004) (440)
- A structural perspective of CTD function. (2005) (416)
- Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry (2010) (399)
- Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast (2011) (390)
- Conservation between the RNA polymerase I, II, and III transcription initiation machineries. (2012) (376)
- RNA polymerase II clustering through carboxy-terminal domain phase separation (2018) (368)
- Structural basis of transcription initiation by RNA polymerase II (2015) (343)
- Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage (2003) (340)
- Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors (2004) (328)
- TT-seq maps the human transient transcriptome (2016) (325)
- Structural basis of RNA polymerase II backtracking, arrest and reactivation (2011) (316)
- Mechanism of SARS-CoV-2 polymerase stalling by remdesivir (2021) (315)
- Structure of eukaryotic RNA polymerases. (2008) (311)
- RNA polymerase II–TFIIB structure and mechanism of transcription initiation (2009) (307)
- Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis (2021) (293)
- Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation (2012) (279)
- Organization and regulation of gene transcription (2019) (275)
- Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution (2002) (269)
- Architecture of the RNA polymerase II–Mediator core initiation complex (2015) (268)
- Architecture of initiation-competent 12-subunit RNA polymerase II (2003) (261)
- Multisubunit RNA polymerases. (2002) (256)
- CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II (2012) (256)
- Structures of Complete RNA Polymerase II and Its Subcomplex, Rpb4/7* (2005) (255)
- Architecture of the RNA polymerase–Spt4/5 complex and basis of universal transcription processivity (2011) (231)
- Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels. (2013) (227)
- CPD Damage Recognition by Transcribing RNA Polymerase II (2007) (224)
- Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis (2013) (213)
- Structure of activated transcription complex Pol II–DSIF–PAF–SPT6 (2018) (210)
- The interaction landscape between transcription factors and the nucleosome (2017) (206)
- RNA polymerase I structure and transcription regulation (2013) (204)
- Transcription initiation complex structures elucidate DNA opening (2016) (201)
- Structure of human mitochondrial RNA polymerase (2011) (195)
- Structure of paused transcription complex Pol II-DSIF-NELF (2018) (191)
- Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation (2008) (186)
- Functional Architecture of RNA Polymerase I (2007) (186)
- Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. (2009) (183)
- Structures of transcription pre-initiation complex with TFIIH and Mediator (2017) (182)
- Structure and function of the initially transcribing RNA polymerase II–TFIIB complex (2012) (181)
- A nano-positioning system for macromolecular structural analysis (2008) (178)
- Structure of transcribing mammalian RNA polymerase II (2016) (173)
- Nucleosome-Chd1 structure and implications for chromatin remodelling (2017) (170)
- Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells (2020) (162)
- Mechanism of transcriptional stalling at cisplatin-damaged DNA (2007) (161)
- The Implication of Early Chromatin Changes in X Chromosome Inactivation (2019) (158)
- Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 (2010) (157)
- Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif (2010) (156)
- CDK9-dependent RNA polymerase II pausing controls transcription initiation (2017) (152)
- RNA polymerase fidelity and transcriptional proofreading. (2009) (143)
- Structure and mechanism of RNA polymerase II CTD phosphatases. (2004) (143)
- Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities. (1996) (138)
- RNA polymerase I contains a TFIIF-related DNA-binding subcomplex. (2010) (137)
- Molecular basis of RNA-dependent RNA polymerase II activity (2007) (132)
- In-cell architecture of an actively transcribing-translating expressome (2020) (126)
- Architecture of a transcribing-translating expressome (2017) (120)
- Heptad-Specific Phosphorylation of RNA Polymerase II CTD. (2016) (119)
- Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20 (2006) (117)
- RNA polymerase II structure: from core to functional complexes. (2004) (117)
- Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function (2020) (117)
- Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. (2012) (116)
- Structure of the human NF‐κB p52 homodimer‐DNA complex at 2.1 Å resolution (1997) (116)
- Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation (2014) (114)
- Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions (2014) (111)
- Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model. (2006) (107)
- Structure and VP16 binding of the Mediator Med25 activator interaction domain (2011) (106)
- AlphaFold2 and the future of structural biology (2021) (105)
- Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. (2002) (104)
- Structural Basis of Transcription : RNA Polymerase II at 2 . 8 Å Resolution (103)
- The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity (2004) (102)
- Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp (2017) (102)
- Structure of a bifunctional DNA primase-polymerase (2004) (101)
- Molecular Basis of Transcription-Coupled Pre-mRNA Capping. (2015) (100)
- Single-molecule tracking of mRNA exiting from RNA polymerase II (2008) (100)
- Structural biology of RNA polymerase III: mass spectrometry elucidates subcomplex architecture. (2007) (99)
- An Extended Winged Helix Domain in General Transcription Factor E/IIEα* (2003) (99)
- Structural Basis of Mitochondrial Transcription Initiation (2017) (98)
- Structure of the Mediator head module (2012) (94)
- Structural basis of transcription elongation. (2013) (94)
- Transcriptome maps of mRNP biogenesis factors define pre-mRNA recognition. (2014) (93)
- Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. (2011) (93)
- A Tandem SH2 Domain in Transcription Elongation Factor Spt6 Binds the Phosphorylated RNA Polymerase II C-terminal Repeat Domain (CTD)* (2010) (91)
- Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex (2009) (90)
- Structural Basis of RNA Polymerase I Transcription Initiation (2017) (90)
- Structural basis of initial RNA polymerase II transcription (2011) (89)
- A Conserved Mediator Hinge Revealed in the Structure of the MED7·MED21 (Med7·Srb7) Heterodimer* (2005) (88)
- Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes. (2017) (88)
- Mechanisms of backtrack recovery by RNA polymerases I and II (2016) (88)
- Core Mediator structure at 3.4 Å extends model of transcription initiation complex (2017) (87)
- A Movie of RNA Polymerase II Transcription (2012) (87)
- A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast (2011) (87)
- Biogenesis of multisubunit RNA polymerases. (2012) (86)
- Structure and Carboxyl-terminal Domain (CTD) Binding of the Set2 SRI Domain That Couples Histone H3 Lys36 Methylation to Transcription* (2006) (85)
- Periodic mRNA synthesis and degradation co‐operate during cell cycle gene expression (2014) (83)
- Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation. (2017) (79)
- Structure of transcription coactivator SAGA (2019) (79)
- Structural basis of TFIIH activation for nucleotide excision repair (2019) (78)
- A movie of the RNA polymerase nucleotide addition cycle. (2009) (78)
- Iwr1 directs RNA polymerase II nuclear import. (2011) (77)
- Structure of RNA polymerase I transcribing ribosomal DNA genes (2016) (76)
- Determinants of RNA metabolism in the Schizosaccharomyces pombe genome (2015) (76)
- A structural perspective on Mediator function. (2012) (76)
- Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome (2019) (75)
- Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex (2017) (75)
- Molecular Basis of Transcriptional Mutagenesis at 8-Oxoguanine* (2009) (73)
- Small-molecule inhibitors of human mitochondrial DNA transcription (2020) (73)
- NASC-seq monitors RNA synthesis in single cells (2018) (71)
- Structure of an RNA polymerase II–RNA inhibitor complex elucidates transcription regulation by noncoding RNAs (2006) (71)
- A conformational switch underlies ClpP protease function. (2011) (70)
- MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation (2019) (70)
- CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response (2020) (70)
- The Spt5 C-Terminal Region Recruits Yeast 3′ RNA Cleavage Factor I (2012) (70)
- Crystal structure of the ankyrin repeat domain of Bcl‐3: a unique member of the IκB protein family (2001) (70)
- Accurate Promoter and Enhancer Identification in 127 ENCODE and Roadmap Epigenomics Cell Types and Tissues by GenoSTAN (2016) (68)
- Structural basis of mitochondrial transcription (2018) (68)
- Structure of transcribing RNA polymerase II-nucleosome complex (2018) (68)
- Evolution of Two Modes of Intrinsic RNA Polymerase Transcript Cleavage♦ (2011) (67)
- Identification, structure, and functional requirement of the Mediator submodule Med7N/31 (2009) (66)
- Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage (2012) (65)
- Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II (2013) (65)
- The mRNA Transcription/Processing Factor Ssu72 Is a Potential Tyrosine Phosphatase* (2003) (65)
- Structure of human mitochondrial RNA polymerase elongation complex (2013) (64)
- Selective Mediator-dependence of cell type-specifying transcription (2020) (63)
- Structure and in vivo requirement of the yeast Spt6 SH2 domain. (2009) (63)
- Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan (2013) (62)
- BRF1 mutations alter RNA polymerase III–dependent transcription and cause neurodevelopmental anomalies (2015) (62)
- Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II (2013) (61)
- RNA polymerase I–Rrn3 complex at 4.8 Å resolution (2016) (60)
- A novel intermediate in transcription initiation by human mitochondrial RNA polymerase (2014) (59)
- Torpedo Nuclease Rat1 Is Insufficient to Terminate RNA Polymerase II in Vitro* (2009) (59)
- Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation (2020) (59)
- Dynamic architecture of a minimal RNA polymerase II open promoter complex. (2012) (58)
- Genome-associated RNA Polymerase II Includes the Dissociable Rpb4/7 Subcomplex* (2008) (57)
- A model for transcription initiation in human mitochondria (2015) (56)
- Mechanism of Transcription Anti-termination in Human Mitochondria (2017) (55)
- Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II. (2018) (54)
- Structure of a transcribing RNA polymerase II–U1 snRNP complex (2020) (54)
- Structure of the mediator subunit cyclin C and its implications for CDK8 function. (2005) (52)
- Model of the Mediator middle module based on protein cross-linking (2013) (52)
- Structural Biology of RNA Polymerase II Transcription: 20 Years On. (2020) (51)
- Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization (2011) (51)
- Promoter Distortion and Opening in the RNA Polymerase II Cleft. (2019) (50)
- Structure-system correlation identifies a gene regulatory Mediator submodule. (2008) (49)
- Stress-induced nuclear condensation of NELF drives transcriptional downregulation (2021) (49)
- RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases (2017) (49)
- Structure and function of RNA polymerase II. (2004) (49)
- Preparation and topology of the Mediator middle module (2010) (48)
- Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement (2007) (48)
- Common structural features of nucleic acid polymerases. (2002) (48)
- Conserved RNA polymerase II initiation complex structure. (2017) (47)
- Mediator Architecture and RNA Polymerase II Interaction. (2016) (46)
- Site specific phosphorylation of yeast RNA polymerase I (2007) (45)
- Template misalignment in multisubunit RNA polymerases and transcription fidelity. (2006) (45)
- The pause-initiation limit restricts transcription activation in human cells (2019) (45)
- Structure of an archaeal RNA polymerase. (2008) (45)
- BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies. (2015) (45)
- Structural basis of nucleosome transcription mediated by Chd1 and FACT (2020) (44)
- Architecture and RNA binding of the human negative elongation factor (2016) (43)
- RNA polymerase III subunit architecture and implications for open promoter complex formation (2012) (43)
- Structure–function studies of the RNA polymerase II elongation complex (2009) (43)
- RNA polymerase II termination involves CTD tyrosine dephosphorylation by CPF subunit Glc7 (2014) (42)
- A Conserved GA Element in TATA-Less RNA Polymerase II Promoters (2011) (42)
- Selenomethionine incorporation in Saccharomyces cerevisiae RNA polymerase II. (2001) (42)
- Global donor and acceptor splicing site kinetics in human cells (2019) (42)
- Multiplexed proteomics mapping of yeast RNA polymerase II and III allows near-complete sequence coverage and reveals several novel phosphorylation sites. (2008) (41)
- Structure of the human Mediator–RNA polymerase II pre-initiation complex (2021) (41)
- The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA (2017) (40)
- The RNA polymerase trigger loop functions in all three phases of the transcription cycle (2013) (40)
- CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation (2020) (40)
- TT‐seq captures enhancer landscapes immediately after T‐cell stimulation (2017) (40)
- Archaeal Transcription: Function of an Alternative Transcription Factor B from Pyrococcus furiosus (2007) (39)
- Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions* (2012) (39)
- Integrator is a genome-wide attenuator of non-productive transcription. (2020) (38)
- Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding (2019) (37)
- Conserved architecture of the core RNA polymerase II initiation complex (2014) (37)
- Structural basis of Integrator-mediated transcription regulation (2021) (36)
- Evidence for additive and synergistic action of mammalian enhancers during cell fate determination (2021) (36)
- Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue (2013) (36)
- Rpb4 Subunit Functions Mainly in mRNA Synthesis by RNA Polymerase II♦ (2014) (36)
- Sequence determinants of human gene regulatory elements (2021) (36)
- Efficient RNA polymerase II pause release requires U2 snRNP function. (2021) (34)
- Structures of mammalian RNA polymerase II pre-initiation complexes (2021) (32)
- Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA) (2012) (31)
- Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations (2020) (31)
- Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. (2021) (30)
- Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. (1997) (29)
- A firm hand on NF?B: structures of the I?BaNF?B complex (1999) (29)
- Scp160p is required for translational efficiency of codon-optimized mRNAs in yeast (2014) (28)
- Structural basis of human transcription–DNA repair coupling (2021) (28)
- Structure of activated transcription complex Pol II–DSIF–PAF–SPT6 (2018) (28)
- The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis (2010) (27)
- Allosteric antibody inhibition of human hepsin protease. (2012) (27)
- Eukaryotic Transcription Turns 50 (2019) (27)
- Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA. (1999) (26)
- Structure of GPN-Loop GTPase Npa3 and Implications for RNA Polymerase II Assembly (2015) (26)
- The RNA Polymerase II C-terminal Domain-interacting Domain of Yeast Nrd1 Contributes to the Choice of Termination Pathway and Couples to RNA Processing by the Nuclear Exosome* (2013) (26)
- Structural basis of RNA processing by human mitochondrial RNase P (2021) (26)
- Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle (2014) (25)
- Multisubunit RNA Polymerases Melt Only a Single DNA Base Pair Downstream of the Active Site* (2007) (25)
- Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms (2019) (24)
- Permissive epigenomes endow reprogramming competence to transcriptional regulators (2020) (24)
- A Tale of Chromatin and Transcription in 100 Structures (2014) (24)
- Engineering of diffraction‐quality crystals of the NF‐κB P52 homodimer:DNA complex (1997) (23)
- RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc 7 (2014) (23)
- Structure of RNA polymerase II pre-initiation complex at 2.9 Å defines initial DNA opening (2021) (23)
- Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes (2019) (23)
- The dynamic machinery of mRNA elongation. (2005) (22)
- Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization (2019) (22)
- DNA photodamage recognition by RNA polymerase II (2007) (22)
- Visualizing translation dynamics at atomic detail inside a bacterial cell (2021) (20)
- Integrator is a genome-wide attenuator of non-productive transcription (2020) (20)
- The Transcription Elongation Factor Bur1-Bur2 Interacts with Replication Protein A and Maintains Genome Stability during Replication Stress* (2010) (19)
- Ruler elements in chromatin remodelers set nucleosome array spacing and phasing (2020) (19)
- The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro (2009) (19)
- Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin (2018) (18)
- The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II (2021) (18)
- The Structural Basis of Transcription: 10 Years After the Nobel Prize in Chemistry. (2016) (17)
- MC EMiNEM Maps the Interaction Landscape of the Mediator (2012) (17)
- Transcriptome maps of general eukaryotic RNA degradation factors (2019) (17)
- Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes (2019) (17)
- Nucleosomal arrangement affects single-molecule transcription dynamics (2016) (16)
- The APT complex is involved in non-coding RNA transcription and is distinct from CPF (2018) (16)
- An alternative RNA polymerase I structure reveals a dimer hinge. (2015) (15)
- Mechanism of RNA polymerase II stalling by DNA alkylation (2017) (14)
- RNA polymerase II clustering through CTD phase separation (2018) (14)
- Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. (2021) (14)
- Structures and implications of TBP–nucleosome complexes (2021) (14)
- RNA velocity of single cells (2017) (14)
- Recent structural studies of RNA polymerases II and III. (2006) (13)
- Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation (2019) (11)
- Complete 12-subunit RNA polymerase II (2003) (11)
- Transcriptionally active enhancers in human cancer cells (2021) (11)
- Transitions for Regulating Early Transcription (2013) (11)
- Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions. (2008) (11)
- Scaling of cellular proteome with ploidy (2021) (10)
- Diastereoselective C-C Bond Formation by Carbene Insertions into Pt-CH3 Bonds (1994) (10)
- Inference of gene regulation functions from dynamic transcriptome data (2016) (10)
- Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir (2020) (10)
- Gene transcription: Extending the message (2007) (9)
- Mechanistic studies of the mRNA transcription cycle. (2006) (8)
- Fluorescence detection of nucleic acids and proteins in multi-component crystals. (2006) (8)
- Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory (2022) (8)
- A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex. (1999) (8)
- Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 (2021) (7)
- The total mRNA concentration buffering system in yeast is global rather than gene-specific (2021) (7)
- Allosteric transcription stimulation by RNA polymerase II super elongation complex. (2021) (7)
- Self-Correcting Messages (2006) (7)
- and Its Subcomplex, Rpb4/7 Structures of Complete RNA Polymerase II Genes: Structure and Regulation: (2014) (6)
- Deciphering the RNA polymerase II structure: a personal perspective (2006) (6)
- Proteins: how RNA polymerases work. (2009) (6)
- Structure of a backtracked hexasomal intermediate of nucleosome transcription. (2022) (6)
- Nucleosome-CHD4 chromatin remodeller structure explains human disease mutations (2019) (6)
- Transcription activation depends on the length of the RNA polymerase II C‐terminal domain (2021) (6)
- A tandem SH2 domain in transcription elongation factor Spt6 (2010) (6)
- Promoter Distortion and Opening in the RNA Polymerase II Cleft (2018) (6)
- Structures of transcription preinitiation complex engaged with the +1 nucleosome (2022) (5)
- Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome (2020) (5)
- Structure determination of transient transcription complexes. (2016) (5)
- Sublinear scaling of the cellular proteome with ploidy (2022) (5)
- Transient transcriptome sequencing: computational pipeline to quantify genome-wide RNA kinetic parameters and transcriptional enhancer activity (2019) (5)
- The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs (2021) (5)
- Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD‐interacting domain fold (2015) (4)
- Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells (2022) (4)
- Author response: CDK9-dependent RNA polymerase II pausing controls transcription initiation (2017) (4)
- Structure of an inactive RNA polymerase II dimer (2021) (4)
- The Mediator Med25 activator interaction domain: Structure and cooperative binding of VP16 subdomains (2011) (4)
- An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples. (2020) (4)
- Structures and diseases (2008) (4)
- Molecular biology. Self-correcting messages. (2006) (3)
- Finding the right spot to start transcription (2007) (3)
- Transient transcriptome sequencing: experimental protocol to monitor genome-wide RNA synthesis including enhancer transcription v1 (2019) (3)
- RNA POLYMERASE II ELONGATION COMPLEX (2001) (3)
- Rosalind Franklin and the Advent of Molecular Biology (2020) (3)
- Structure of the transcription coactivator SAGA (2020) (3)
- Cap completion and CTD kinase recruitment underlie the initiation (2013) (3)
- Molecular bioimaging of gene transcription (2007) (3)
- Structure of the Mediator subunit cyclin C (2005) (3)
- Dimeric form of SARS-CoV-2 polymerase (2021) (3)
- The structure of a dimeric form of SARS-CoV-2 polymerase (2021) (3)
- Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin. (2018) (3)
- Proteins: histones and chromatin. (2011) (2)
- Structural Molecular Biology-A Personal Reflection on the Occasion of John Kendrew's 100th Birthday. (2017) (2)
- Henry Moore, catalogue of graphic work (1973) (2)
- growth Molecular basis of Rrn 3-regulated RNA polymerase I initiation and cell (2011) (2)
- Joan Miro the Illustrated Books: Catalogue Raisonne (1989) (2)
- One Hand Clapping: detection of condition-specific transcription factor interactions from genome-wide gene activity data (2012) (2)
- Architecture of the RNA polymerase II-Mediator core transcription initiation complex (2015) (2)
- Periodic mRNA synthesis and degradation co‐operate during cell cycle gene expression (2014) (2)
- Crystal structure of RNA Polymerase II in complex with TFIIB (2009) (2)
- Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II (2022) (2)
- Refined RNA Polymerase II-TFIIS complex (2004) (2)
- Towards molecular systems biology of gene transcription and regulation (2010) (2)
- Transcription Mechanism Architecture of RNA Polymerase II and Implications (2010) (2)
- Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain (2023) (1)
- Author response: Transcriptome maps of general eukaryotic RNA degradation factors (2019) (1)
- Structure of human Mediator-RNA polymerase II transcription pre-initiation complex (2021) (1)
- Recent structural studies of RNA polymerases II (2006) (1)
- RNA Polymerase II-TFIIS-DNA/RNA complex (2004) (1)
- in Vitro Terminate RNA Polymerase II Nuclease Rat 1 Is Insufficient to Torpedo Epigenetics : Transcription , Chromatin , and (2009) (1)
- Oct4 primarily controls enhancer activity rather than accessibility (2021) (1)
- Distinct transcription kinetics of pluripotent cell states (2022) (1)
- Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function (2020) (1)
- Nano-Positioning-System Reveals Structure of the RNA Polymerase II Initially Transcribing Complex (ITC) (2011) (1)
- STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR (2018) (1)
- Maps the Interaction Landscape of the Mediator (2012) (1)
- Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1- Triple mutant F50M/L107M/L110M manganese soak (2004) (1)
- Structure and CTD binding of the Set2 SRI domain (2005) (1)
- Multiprotein machines for gene transcription (2007) (0)
- Author response: Evidence for additive and synergistic action of mammalian enhancers during cell fate determination (2021) (0)
- SAGA DUB module bound to a ubiqitinated nucleosome (2020) (0)
- Michael Polymerase Transcript Cleavage Evolution of Two Modes of Intrinsic RNA Gene Regulation (2011) (0)
- Structure of transcribing RNA polymerase II-nucleosome complex (2018) (0)
- RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid (2011) (0)
- RNA polymerase I initially transcribing complex (2017) (0)
- RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history (2022) (0)
- mRNA transcription and its regulation by RNA (2006) (0)
- Yeast TFIIH in the expanded state within the pre-initiation complex (2021) (0)
- NASC-seq monitors RNA synthesis in single cells (2019) (0)
- Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) (2020) (0)
- Elongation complex of RNA polymerase II with a hepatitis delta virus-derived RNA stem loop (2007) (0)
- Author response: Inference of gene regulation functions from dynamic transcriptome data (2016) (0)
- Human hepsin protease in complex with the Fab fragment of an inhibitory antibody (2011) (0)
- RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid and soaked with AMPCPP (2011) (0)
- Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site. (2009) (0)
- Inhibition of DNA replication and miscoding potential of minor groove alkylation: Structure-function insight from 3-deazaadenosines. (2016) (0)
- Structure of a non-canonical CID of Ctk3 (2015) (0)
- Supporting Online Material for CPD Damage Recognition by Transcribing RNA Polymerase II (2006) (0)
- Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States (2021) (0)
- Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) (2010) (0)
- RNA polymerase II elongation complex in the presence of 3d-Napht-A (2017) (0)
- The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution. (2007) (0)
- cryo-EM structure of transcription coactivator SAGA (2020) (0)
- RNA polymerase II clustering through carboxy-terminal domain phase separation (2018) (0)
- PRESIDENT CHOSEN FOR THE MAX PLANCK SOCIETY (2022) (0)
- Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation (2020) (0)
- CPD lesion containing RNA Polymerase II elongation complex A (2007) (0)
- Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir (2021) (0)
- Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand. (2004) (0)
- Structural biology of eukaryotic gene transcription (2011) (0)
- Crystal structure of negative elongation factor subcomplex NELF-AC (2016) (0)
- Publisher Correction: Visualizing translation dynamics at atomic detail inside a bacterial cell (2022) (0)
- Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome (2019) (0)
- The interaction landscape between transcription factors and the nucleosome (2018) (0)
- Structure of the Schizosaccharomyces pombe Mediator head module (2012) (0)
- Crystal structure of the KOW6-KOW7 domain of human DSIF (2017) (0)
- Structure of the Mediator submodule Med7N/31 (2008) (0)
- Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNA (2021) (0)
- Structure of a yeast closed complex with distorted DNA (core CCdist) (2018) (0)
- Elongation complex of RNA polymerase II with artificial RdRP scaffold (2007) (0)
- Structural basis of TFIIH activation for nucleotide excision repair (2019) (0)
- Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding (2019) (0)
- Patrick Cramer Anton Meinhart , Tobias Silberzahn and Phosphatase Factor Ssu 72 Is a Potential Tyrosine The mRNA Transcription / Processing REGULATION : GENES : STRUCTURE (2003) (0)
- Yeast RNAP II containing poly(A)-signal sequence in the active site (2009) (0)
- RNA Polymerase II initial transcribing complex with a 2nt DNA-RNA hybrid (2012) (0)
- RNA Cleavage Factor I ' 3Spt5 C-Terminal Region Recruits Yeast (2014) (0)
- Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) (2017) (0)
- RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid (2011) (0)
- Abstract OR-2: Investigating Interaction of Pioneering Transcription Factors with Nucleosomes Using Cryo-Electron Microscopy (2019) (0)
- Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by (cid:2) -amanitin (2020) (0)
- Struggling to let go: a non‐coding RNA directs its own extension and destruction (2013) (0)
- RNA Polymerase II initial transcribing complex with a 4nt DNA-RNA hybrid and soaked with AMPCPP (2011) (0)
- Errata: BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies (Genome Research (2015) 25 (155-166)) (2015) (0)
- Structure of human Sox11 transcription factor in complex with a nucleosome (2020) (0)
- In Brief | MaxPlanckResearch 1/2021: Living with Extremes (2021) (0)
- Pablo Picasso. The Illustrated Books: Catalogue Raisonné (1983) (0)
- GPN-loop GTPase Npa3 in complex with GMPPCP (2016) (0)
- Structure of the Mediator head submodule Med8C/18/20 (2006) (0)
- Position of the non-template DNA in the Polymerase II elongation complex revealed using single-molecule Fluorescence Resonance Energy Transfer (2009) (0)
- Arrested RNA Polymerase II reactivation intermediate (2011) (0)
- Crystal structure of ClpP from Staphylococcus aureus (2011) (0)
- Macromolecular assemblages — from molecules to functional modules. (2005) (0)
- Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. (2020) (0)
- Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble (2021) (0)
- Structure of RNA polymerase II-TFIIB complex (2012) (0)
- Structure of H. sapiens SPT6 tandem SH2 domain (2018) (0)
- Cramer Sonja Baumli , Sabine Hoeppner and Patrick ( Med 7 · Srb 7 ) Heterodimer the Structure of the MED 7 · MED 21 A Conserved Mediator Hinge Revealed in Genes : Structure and Regulation (2005) (0)
- RNA Polymerase II initial transcribing complex with a 4nt DNA-RNA hybrid (2011) (0)
- RNA Polymerase II initial transcribing complex with a 2nt DNA-RNA hybrid and soaked with GMPCPP (2011) (0)
- 8-oxoguanine containing RNA polymerase II elongation complex D (2009) (0)
- Author response: RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases (2017) (0)
- Transcription | Gene Expression in Eukaryotes: RNA Polymerase II Structure (2021) (0)
- Dynamic Architecture of the RNA Polymerase II Open Promoter Complex (2012) (0)
- cell growth Molecular basis of Rrn 3-regulated RNA polymerase I initiation and (2011) (0)
- Structure of nucleosome-Chd1 complex (2017) (0)
- Human Mediator with RNA Polymerase II Pre-initiation complex (2021) (0)
- What are the key aspects of interaction between RNA polymerase II C-terminal domain phosphorylated on tyrosine-1 and the elongation factors (2016) (0)
- Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes Graphical (2017) (0)
- Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM (2017) (0)
- Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) (2021) (0)
- , RNA Cleavage Factor I ′ 3 The Spt 5 C-Terminal Region Recruits Yeast (2012) (0)
- Yeast TFIIH in the contracted state within the pre-initiation complex (2021) (0)
- 500 years after the first circumnavigation of the world: the efforts, rewards and drawbacks of exploration (2019) (0)
- Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA (2021) (0)
- Structure of RNA Polymerase II-Tfg1 peptide complex (2016) (0)
- Crystal structure of human Maf1 (2010) (0)
- Gene Expression in Eukaryotes: RNA Polymerase II Structure (2013) (0)
- Selective Mediator dependence of cell-type-specifying transcription (2020) (0)
- Biochemical Society Annual Symposium 'Transcription UK 2005' (2005) (0)
- Organization and regulation of gene transcription (2019) (0)
- Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) (2020) (0)
- Crystal structure of the primase-polymerase from Sulfolobus islandicus (2010) (0)
- E. coli expressome (2017) (0)
- Structure of human mitochondrial transcription elongation factor (TEFM) C-terminal domain (2017) (0)
- DORSAL HOMOLOGUE GAMBIF1 BOUND TO DNA (1999) (0)
- Supplemental Information MYC Recruits SPT 5 to RNA Polymerase II to Promote Processive Transcription Elongation (2019) (0)
- BARNASE MUTANT WITH ILE 96 REPLACED BY ALA (1995) (0)
- HUMAN NF-KAPPA-B P52 BOUND TO DNA (1998) (0)
- Structural basis of transcripti polymerase II cocrystal at 2. (2016) (0)
- Structural basis of transcription reduction by a promoter-proximal +1 nucleosome (2023) (0)
- Structure of the core Vaccinia Virus DNA-dependent RNA polymerase complex (2019) (0)
- Structural basis of mitochondrial transcription (2018) (0)
- Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 (2020) (0)
- RNA Polymerase II elongation complex containing a CPD Lesion (2012) (0)
- Proteins : histones and chromatin Editorial overview (2011) (0)
- Resource Heptad-Specific Phosphor ylation of RNA Polymerase II CTD Highlights (2016) (0)
- Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir (2021) (0)
- The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model (2004) (0)
- Crystal structure of S. cerevisiae Core Factor at 3.2A resolution (2017) (0)
- Crystal structure of the RNA Polymerase I subcomplex A14/43 (2008) (0)
- Supplemental Information Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes (2017) (0)
- Structure of the human mitochondrial transcription initiation complex at the HSP promoter (2017) (0)
- Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1 (2004) (0)
- Annotation of genomics data by the bidirectional hidden Markov model unveils variations in Pol II transcription cycle (2015) (0)
- Monitoring mRNA metabolism (2015) (0)
- Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C (2012) (0)
- Structure of the SH2 domain of the Candida glabrata transcription elongation factor Spt6, crystal form A (2009) (0)
- Structure of Vaccinia Virus DNA-dependent RNA polymerase co-transcriptional capping complex (2019) (0)
- Structure of the mediator MED7/MED21 (Med7/Srb7) subcomplex (2005) (0)
- Structure of the Schizosaccharomyces pombe Mediator subunit Med6 (2012) (0)
- Macromolecular assemblages — from molecules to functional modules Editorial overview (2005) (0)
- CRYSTALLOGRAPHIC BACKBONE MODEL OF RNA POLYMERASE II (2000) (0)
- Structure of yeast Rmd9p in complex with 16nt target RNA (2021) (0)
- In vitro reconstitution of chromatin domains (2023) (0)
- Arrested RNA polymerase II-Bye1 complex (2013) (0)
- Complete RNA polymerase II elongation complex I with a T-U mismatch (2009) (0)
- Mechanism of SARS-CoV-2 polymerase stalling by remdesivir (2021) (0)
- elongating RNA Polymerase II-Bye1 TLD complex (2013) (0)
- RNA polymerase I structure with an alternative dimer hinge (2015) (0)
- Three-dimensional structure of a RNA-polymerase II binding protein. (2004) (0)
- Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP (2005) (0)
- Molecular Cell Alternative Binding of Nrd 1 to RNAPII CTD and Trf (2014) (0)
- Cisplatin lesion containing RNA polymerase II elongation complex (2007) (0)
- Crystal Structure of RNA Polymerase I Transcription Initiation Factor Rrn3 (2011) (0)
- STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH (2018) (0)
- RNA polymerase II-TFIIS complex (2003) (0)
- Elisabeth Synthesis by RNA Polymerase II Rpb 4 Subunit Functions Mainly in mRNA (2014) (0)
- RNA POLYMERASE II CRYSTAL FORM II AT 2.8 A RESOLUTION (2001) (0)
- RNA Polymerase II-Bye1 complex (2013) (0)
- Structure of an RNA polymerase II-DSIF transcription elongation complex (2017) (0)
- Supplemental Information Spt 5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation (2017) (0)
- Structure of the Mediator head subcomplex Med18/20 (2006) (0)
- RNA polymerase II core pre-initiation complex with open promoter DNA (2021) (0)
- Joan Miró, litógrafo (1972) (0)
- Structure of activated transcription complex Pol II-DSIF-PAF-1 SPT 6 2 3 (2019) (0)
- RNA Polymerase II binary complex with DNA (2012) (0)
- Structure of the complete Vaccinia DNA-dependent RNA polymerase complex (2019) (0)
- mutual feedback between mRNA synthesis and degradation Comparative dynamic transcriptome analysis ( cDTA ) reveals Material Supplemental (2012) (0)
- Structure of human TFB2M (2017) (0)
- Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 (2021) (0)
- Structure of paused transcription complex Pol II–DSIF–NELF (2018) (0)
- Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II (2012) (0)
- Repeat Domain ( CTD ) Phosphorylated RNA Polymerase II Elongation Factor Spt 6 Binds the A Tandem SH 2 Domain in Transcription Gene Regulation : (2010) (0)
- Complete 12-Subunit RNA Polymerase II at 3.8 Angstrom (2004) (0)
- MolecularBasisofTranscription-CoupledPre-mRNA Capping (2015) (0)
- BARNASE MUTANT WITH ILE 88 REPLACED BY ALA (1995) (0)
- Crystal structure of yeast subcomplex of Rpb4 and Rpb7 (2004) (0)
- Crystal structure of Spt4/5NGN heterodimer complex from Methanococcus jannaschii (2010) (0)
- Structure of RNA polymerase I at 2.8 A resolution (2013) (0)
- Crystal structure of extended Dimerization module of RNA polymerase I subcomplex A49/A34.5 (2010) (0)
- Crystal structure of the KOWx-KOW4 domain of human DSIF (2017) (0)
- Mediator structure and function in transcription initiation (2023) (0)
- Free monomeric RNA polymerase I at 4.0A resolution (2016) (0)
- Response Transcription During Non-stress Mediator Phosphorylation Prevents Stress Gene Regulation : (2012) (0)
- RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position (2021) (0)
- CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response (2020) (0)
- Complete RNA polymerase II elongation complex II (2009) (0)
- Author response: Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations (2020) (0)
- Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18 (2008) (0)
- Polymerase II Initiation-Elongation Transition of RNA Domain Kinase Recruitment Underlie the Cap Completion and C-Terminal Repeat (2013) (0)
- X-ray structure of RNA polymerase III subcomplex C17-C25. (2006) (0)
- Molecular Basis of Transcr iption-CoupledPre-mRNA Capping Graphical Abstract Highlights (2015) (0)
- Structure of the mediator MED7/MED21 subcomplex (2005) (0)
- BARNASE MUTANT WITH ILE 76 REPLACED BY ALA (1995) (0)
- Complete RNA Polymerase II-RNA inhibitor complex (2005) (0)
- Alpha-amanitin inhibited complete RNA polymerase II elongation complex (2008) (0)
- Crystal Structure of Human Mitochondrial RNA Polymerase (2011) (0)
- Structure of yeast Rmd9p in complex with 20nt target RNA (2021) (0)
- C-terminal Repeat Domain (CTD) Phosphorylated RNA Polymerase II Elongation Factor Spt6 Binds the A Tandem SH2 Domain in Transcription (2014) (0)
- Welch Award in Chemistry / And also in the News. (2019) (0)
- submodule system correlation identifies a gene regulatory Mediator − Structure Material Supplemental (2008) (0)
- MYCRecruits SPT 5 to RNA Polymerase II to Promote Processive Transcription Elongation Graphical (2019) (0)
- Structure of an initially transcribing RNA polymerase II-TFIIB complex (2012) (0)
- RNA Polymerase II Structure in Eukaryotes (2004) (0)
- Arrested RNA Polymerase II elongation complex (2011) (0)
- Complete RNA polymerase II elongation complex III with a T-U mismatch and a frayed RNA 3'-uridine (2009) (0)
- elongating RNA Polymerase II-Bye1 TLD complex soaked with AMPCPP (2013) (0)
- Taking the first steps : How ribosome biogenesis starts (2017) (0)
- Structure of AFF4 C-terminal homology domain (2019) (0)
- RNA Polymerase II initial transcribing complex with a 5nt DNA-RNA hybrid (2011) (0)
- Structure of Vaccinia Virus DNA-dependent RNA polymerase elongation complex (2019) (0)
- Genome transcription and regulation. (2017) (0)
- Selenomethionine Incorporation Technical Advance in Saccharomyces cerevisiae RNA Polymerase II (2001) (0)
- Patrick Cramer Resolution Structural Basis of Transcription : RNA Polymerase II at 2 . 8 Ångstrom (2014) (0)
- Structure of the core TFIIH-XPA-DNA complex (2019) (0)
- Core Mediator of transcriptional regulation (2017) (0)
- Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin (2002) (0)
- Yeast RNA polymerase II transcription pre-initiation complex (consensus) (2021) (0)
- RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid and soaked with AMPCPP (2011) (0)
- Yeast RNA polymerase I elongation complex at 3.8A (2016) (0)
- Methylation to Transcription 36 That Couples Histone H 3 Lys ( CTD ) Binding of the Set 2 SRI Domain Structure and Carboxyl-terminal Domain Accelerated Publications (2005) (0)
- BARNASE MUTANT WITH LEU 14 REPLACED BY ALA (1995) (0)
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