Patrick Hogan
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American biologist
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Patrick Hogan biology Degrees
Biology
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Genetics
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Molecular Biology
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Biology
Patrick Hogan 's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Genetics Stanford University
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Why Is Patrick Hogan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Patrick G. Hogan is a cellular and molecular biologist who studies how cellular signaling leads to gene expression. He obtained his bachelor’s degree from Harvard University and a PhD in neurobiology from Harvard Medical School. In 2010, he moved to the La Jolla Institute for Immunology in San Diego as a Professor in the Division of Signaling and Gene Expression. He is a Founder and Member of the Scientific Advisory Board, CalciMedica Inc, La Jolla, CA.
Patrick Hogan 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transcription factors of the NFAT family: regulation and function. (1997) (2747)
- A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function (2006) (2175)
- Transcriptional regulation by calcium, calcineurin, and NFAT. (2003) (1884)
- Orai1 is an essential pore subunit of the CRAC channel (2006) (1330)
- Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. (2010) (703)
- Defining ‘T cell exhaustion’ (2019) (604)
- Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. (1999) (594)
- Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008) (576)
- Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA (1998) (500)
- Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. (2000) (471)
- The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. (2015) (465)
- Biochemical and Functional Characterization of Orai Proteins* (2007) (381)
- A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT (2006) (374)
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion (2019) (369)
- Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. (1996) (363)
- Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. (1995) (355)
- Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX (2013) (323)
- Interaction of calcineurin with substrates and targeting proteins. (2011) (300)
- Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. (1998) (298)
- Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. (2007) (297)
- Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1 (2008) (282)
- Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells. (1983) (244)
- Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex (2011) (237)
- STIM1 gates the store-operated calcium channel ORAI1 in vitro (2010) (232)
- Novel cell lines display properties of nociceptive sensory neurons (1990) (227)
- Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes (1996) (213)
- An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry (2013) (205)
- Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells (2017) (200)
- Initial activation of STIM1, the regulator of store-operated calcium entry (2013) (181)
- Ca2+/calcineurin signalling in cells of the immune system. (2003) (177)
- Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. (1996) (174)
- Proteomic mapping of ER-PM junctions identifies STIMATE as regulator of Ca2+ influx (2015) (162)
- Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. (2004) (159)
- Store-operated calcium entry: Mechanisms and modulation. (2015) (158)
- Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation (2015) (142)
- Pore architecture of the ORAI1 store-operated calcium channel (2010) (138)
- Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling (2012) (133)
- T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1 (1996) (133)
- Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. (1994) (131)
- Household versus individual approaches to eradication of community-associated Staphylococcus aureus in children: a randomized trial. (2012) (130)
- Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. (2007) (124)
- A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection. (2013) (123)
- Mupirocin and Chlorhexidine Resistance in Staphylococcus aureus in Patients with Community-Onset Skin and Soft Tissue Infections (2012) (120)
- Dissecting ICRAC, a store-operated calcium current. (2007) (118)
- Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility (2016) (113)
- A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function. (2007) (100)
- Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells (*) (1995) (99)
- Calcium-NFAT transcriptional signalling in T cell activation and T cell exhaustion. (2017) (90)
- Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. (2004) (79)
- STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel (2014) (77)
- BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells (2021) (76)
- Immunohistochemical Characterisation of Macrophages in Human Liver and Gastrointestinal Tract: Expression of CD4, HLA‐DR, OKM1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue (1987) (72)
- Domain Architecture of the Regulators of Calcineurin (RCANs) and Identification of a Divergent RCAN in Yeast (2009) (71)
- The STIM1-ORAI1 microdomain. (2015) (71)
- Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp (1995) (68)
- ORAI1 calcium channel orchestrates skin homeostasis (2013) (63)
- An asymmetric NFAT1 dimer on a pseudo-palindromic κB-like DNA site (2003) (61)
- Staphylococcus aureus colonization in children with community-associated Staphylococcus aureus skin infections and their household contacts. (2012) (61)
- Lymphokine-activated and natural killer cell activity in human intestinal mucosa. (1985) (60)
- Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm. (2018) (58)
- Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding. (1994) (56)
- TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling (2015) (56)
- Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development (2009) (53)
- Intradermal Recombinant Hepatitis B Vaccine for Healthcare Workers Who Fail to Respond to Intramuscular Vaccine (2002) (51)
- Contamination of environmental surfaces with Staphylococcus aureus in households with children infected with methicillin-resistant S aureus. (2014) (51)
- Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells. (1992) (47)
- Advanced donor-origin melanoma in a renal transplant recipient: immunotherapy, cure, and retransplantation. (1998) (47)
- Inhibition of the Calcineurin-NFAT Interaction by Small Organic Molecules Reflects Binding at an Allosteric Site* (2005) (46)
- Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells. (1992) (46)
- Calcium sensing by the STIM1 ER-luminal domain (2018) (46)
- STIM-ORAI interactions that control the CRAC channel. (2013) (43)
- Discriminatory Indices of Typing Methods for Epidemiologic Analysis of Contemporary Staphylococcus aureus Strains (2015) (35)
- Muscle activity decreases rate of degradation of α-bungarotoxin bound to extrajunctional acetylcholine receptors (1976) (35)
- Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study. (2019) (34)
- Transcriptional and epigenetic regulation of T cell hyporesponsiveness (2017) (29)
- Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge. (2016) (29)
- Calcium signaling in cells of the immune and hematopoietic systems (2009) (29)
- L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins (2020) (28)
- Identification of a B2 bradykinin receptor expressed by PC12 pheochromocytoma cells. (1994) (28)
- Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling (2019) (28)
- An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. (2003) (24)
- Interplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus. (2019) (24)
- Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S aureus skin and soft tissue infections. (2014) (24)
- Impact of Systemic Antibiotics on Staphylococcus aureus Colonization and Recurrent Skin Infection (2018) (23)
- Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor (2019) (21)
- What are killer cells and what do they do? (1988) (20)
- The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel. (2017) (20)
- Diversity of Staphylococcus aureus strains colonizing various niches of the human body. (2016) (19)
- A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure (2018) (19)
- Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households (2018) (19)
- Transcriptional regulation: Modification by nuclear export? (1999) (18)
- Vitamin D Sufficiency and Staphylococcus Aureus Infection in Children (2015) (18)
- Environmental Methicillin-resistant Staphylococcus aureus Contamination, Persistent Colonization, and Subsequent Skin and Soft Tissue Infection. (2020) (17)
- Measurement and Impact of Staphylococcus aureus Colonization Pressure in Households. (2013) (16)
- STIM calcium sensing and conformational change (2020) (16)
- Molecular Epidemiology of Recurrent Cutaneous Methicillin-Resistant Staphylococcus aureus Infections in Children. (2014) (15)
- Molecular Epidemiology of Methicillin-resistant Staphylococcus aureus Isolated in Serial Cultures From the Respiratory Tract of Children with Cystic Fibrosis (2014) (15)
- Topical Decolonization Does Not Eradicate the Skin Microbiota of Community-Dwelling or Hospitalized Adults (2016) (15)
- The Ca2+–calcineurin–NFAT signalling pathway (2007) (14)
- Evaluation of Environmental Sampling Methods for Detection of Staphylococcus aureus on Fomites. (2015) (11)
- Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates (2021) (10)
- Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children (2020) (10)
- Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction (2014) (10)
- HOME2: Household vs. Personalized Decolonization in Households of Children with Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection - A Randomized Clinical Trial. (2020) (9)
- Anaphylactoid reactions in patients on hemodiafiltration with AN69 membranes whilst receiving ACE inhibitors. (1991) (9)
- Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene. (1996) (8)
- Skin and Soft Tissue Infection Treatment and Prevention Practices by Pediatric Infectious Diseases Providers. (2019) (8)
- A unique secreted adenovirus E 3 protein binds to the leukocyte common antigen CD 45 and modulates leukocyte functions (2013) (8)
- Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA. (2017) (7)
- Author response: Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation (2015) (6)
- Practices and Procedures to Prevent the Transmission of Skin and Soft Tissue Infections in High School Athletes (2012) (6)
- Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA (1998) (6)
- Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling (2015) (6)
- Conformational Isomers of Calcineurin Follow Distinct Dissociation Pathways (2012) (6)
- Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products (2004) (5)
- Antimicrobial Susceptibility Profiles of Staphylococcus aureus Isolates Recovered from Humans, Environmental Surfaces, and Companion Animals in Households of Children with Community-Onset Methicillin-Resistant S. aureus Infections (2015) (5)
- Correction for Seo et al., TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion (2019) (5)
- Factors influencing degradation of extrajunctional acetylcholine receptors in skeletal muscle. (1977) (5)
- Spatial relationships among public places frequented by families plagued by methicillin-resistant Staphylococcus aureus (2018) (4)
- Signaling ER Store Depletion to Plasma Membrane Orai Channels (2017) (4)
- Methicillin‐Resistant Staphylococcus aureus: The Effects Are More Than Skin Deep (2018) (4)
- Author response: Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility (2016) (3)
- Emergency Department Environmental Contamination With Methicillin-Resistant Staphylococcus aureus After Care of Colonized Patients. (2019) (3)
- Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin (2018) (3)
- Phenotypic Variation Is Almost Entirely Independent of the Host-Pathogen Relationship in Clinical Isolates of S. aureus (2015) (3)
- Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection (2020) (3)
- HOME 2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection—A Randomized Clinical Trial (2020) (2)
- Compliance, Feasibility, and Cost of a Methicillin-Resistant Staphylococcus aureus Decolonization Protocol (2015) (2)
- The STIM-Orai Pathway (2012) (2)
- Paramagnetic Pharmaceuticals for Functional Studies (1987) (2)
- Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in Vitro (2010) (2)
- 6.9 STIM1-ORAI1 Store-Operated Calcium Channels (2012) (2)
- Insights into CRAC channel gating and ion permeation (2012) (2)
- Calcium signals regulate the functional differentiation of thymic iNKT cells (2021) (2)
- Conformational Switching Mechanisms Underlying the Activation of Stromal Interaction Molecule 1 (STIM1) (2013) (1)
- Ca2+/calcineurin signalling promotes yeast survival during environmental stress (2007) (1)
- Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates. (2018) (1)
- Antimicrobial Susceptibility Profiles of Staphylococcus aureus (SA) Isolates Recovered from Humans, Environmental Surfaces, and Companion Animals in Households of Children with Community-Associated Methicillin-Resistant S. aureus (CA-MRSA) Infections (2015) (1)
- Calcineurin: A star is reborn. (2021) (1)
- Proteomic Mapping and Optogenetic Control of ER-PM Junctions in Living Cells (2016) (0)
- A genome-wide RNAi screen in Drosophila identifies novel regulators of the Ca 2+ / calcineurin/ NFAT signalling pathway (2006) (0)
- Spatial relationships among public places frequented by families plagued by methicillin-resistant Staphylococcus aureus (2018) (0)
- Novel Modulators of STIM-ORAI Calcium Entry Pathway (2012) (0)
- An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site (2003) (0)
- Comparing the Yield of Staphylococcus aureus Recovery with Static versus Agitated Broth Incubation (2018) (0)
- InfectionsSkin and Soft Tissue Staphylococcus aureus in Patients with Mupirocin and Chlorhexidine Resistance in (2014) (0)
- Prevalence of and Risk Factors for Persistent Staphylococcus aureus Colonization (2015) (0)
- STIM1 Function Is Controlled by Multiple Ca 2+ Binding Sites in its Luminal Domain (2018) (0)
- 589. Impact of Parents and the Environment on MRSA Transmission in the Neonatal ICU (2019) (0)
- Plasma Membrane Orai1 and Septin Organization during Calcium Signalling (2017) (0)
- Longitudinal Dynamics of Skin Bacterial Communities in the Context of Staphylococcus aureus Decolonization (2022) (0)
- Control factor of Nfat (2007) (0)
- The role of nonspecific cytotoxic cells and cytokine production in the pathogenesis of human intestinal diseases (1988) (0)
- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Level 4 Neonatal Intensive Care Unit (2015) (0)
- Some rat sensory neurons in cultur differentiated pain sensory cells (trigeminal ganglion neurons/capsaicin/bradykinin/prostaglandin I (2016) (0)
- Skin and Soft Tissue Infection Treatment and Prevention Practices by Pediatric Emergency Medicine Providers (2022) (0)
- The impact of infectious diseases consultation for children with Staphylococcus aureus bacteremia (2022) (0)
- Near-Infrared Photoactivatable Control of Calcium Signaling (2016) (0)
- Mechanism of Activation of Calcium Channel Orai1 by its Regulatory Partner Stim1 (2014) (0)
- Antimicrobial Susceptibility Profiles of Staphylococcus aureus Isolates Recovered from Humans, 1 (2015) (0)
- Molecular Epidemiology of Staphylococcus aureus Colonizing Pets in Households of Children with Methicillin-Resistant S aureus Skin and Soft Tissue Infections (2015) (0)
- Magnetic resonance imaging of the delivery of a paramagnetic contrast agent by an osmotic pump. (1988) (0)
- Calcium sensing by the STIM1 ER-luminal domain (2018) (0)
- Probing the Mechanisms by which Septins Regulate ORAI1 Function (2019) (0)
- Calcium Sensing and Conformational Rearrangements in STIM1, the ER Calcium Sensor (2019) (0)
- Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide (2007) (0)
- Oral abstractIntracellular calcium mobilization: Molecular cloning of the rat lactotroph thyrotropin-releasing hormone receptor and the actions of cyclic ADP-ribose in mammalian cells (1992) (0)
- Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling (2019) (0)
- The Mechanics of STIM-ORAI Communication (2015) (0)
- Characterization of the Calcium Release-Activated Calcium (CRAC) Channel From the Human Pathogen Schistosoma mansoni (2018) (0)
- Familial and Environmental Impact on Colonization with Antibiotic-resistant Organisms in the Neonatal Intensive Care Unit (2017) (0)
- Crystal Structure of Calcineurin in Complex with AKAP79 Peptide (2011) (0)
- Running Title: S. aureus Mupirocin and Chlorhexidine Resistance (2012) (0)
- ORAI Store-Operated Calcium Channel (2013) (0)
- Emergency department environmental contamination with methicillin-resistant Staphylococcus aureus following care of colonized patients (2019) (0)
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