Patrick Maxwell

Q: What Schools Are Affiliated With Patrick Maxwell

Patrick Maxwell is affiliated with the following schools: University of Cambridge, Rensselaer Polytechnic Institute, University at Albany, SUNY, Imperial College London, University of Oxford, University College London

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Patrick Maxwell

Physics

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Physics

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According to Wikipedia, Patrick Henry Maxwell FMedSci is a British physician and the Regius Professor of Physic at the University of Cambridge, a position he has held since 2012. His research focuses regulation of gene expression by changes in oxygen. Patrick studied for a DPhil in Medicine at Corpus Christi College, Oxford. He undertook postgraduate clinical and research training in nephrology and general medicine at Guy's Hospital and in Oxford.

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Patrick Maxwell 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999) (4924)
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation (2001) (4708)
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation (2001) (3193)
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (2183)
Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (2000) (1265)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages (2000) (1112)
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. (1997) (1071)
Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation (2001) (1062)
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005) (912)
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* (2000) (858)
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization (2009) (781)
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs (2003) (748)
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. (1998) (686)
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998) (1998) (579)
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. (2002) (528)
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. (2002) (499)
Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling (2011) (491)
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia (2002) (488)
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (2008) (482)
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL (2002) (454)
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. (2000) (413)
Activation of the HIF pathway in cancer. (2001) (411)
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors (2018) (408)
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. (1993) (400)
Identification of the renal erythropoietin-producing cells using transgenic mice. (1993) (393)
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils (2006) (372)
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. (2001) (364)
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. (1998) (357)
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. (2001) (334)
Oxygen sensors and angiogenesis. (2002) (326)
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. (2006) (325)
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney (2006) (318)
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. (2003) (299)
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis (2011) (293)
Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis (2010) (292)
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling (2000) (288)
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. (2002) (282)
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. (2006) (268)
Genetic loci influencing kidney function and chronic kidney disease (2010) (266)
Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease (2010) (265)
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. (2008) (258)
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels (2009) (240)
HIF-1, An Oxygen and Metal Responsive Transcription Factor (2004) (235)
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond (2016) (218)
HLA has strongest association with IgA nephropathy in genome-wide analysis. (2010) (216)
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (2002) (213)
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. (2009) (210)
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice (2008) (206)
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. (2005) (199)
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. (1998) (194)
Genetic evidence for a tumor suppressor role of HIF-2alpha. (2005) (192)
Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin (2010) (190)
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. (2010) (187)
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology (2006) (184)
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. (2011) (180)
The HIF pathway in cancer. (2005) (176)
Hypoxia‐inducible factor as a physiological regulator (2005) (175)
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. (2007) (173)
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. (2006) (157)
HIF-1: an oxygen response system with special relevance to the kidney. (2003) (144)
The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma (2001) (141)
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. (2008) (140)
Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees. (2011) (131)
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. (2010) (130)
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. (2014) (129)
Retrotransposition is associated with genome instability during chronological aging (2011) (128)
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes (2019) (128)
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. (2008) (125)
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition (2013) (123)
The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress (2008) (121)
Persistent induction of HIF‐1α and ‐2α in cardiomyocytes and stromal cells of ischemic myocardium (2004) (118)
Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. (2009) (113)
HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. (2016) (111)
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene (2004) (107)
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis (2002) (107)
Hypoxia response elements. (1997) (107)
The hypoxia response pathway and β‐cell function (2010) (105)
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. (2006) (104)
The use of dioxygen by HIF prolyl hydroxylase (PHD1). (2002) (103)
Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection. (2010) (103)
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia (2010) (99)
Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. (2002) (96)
correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (94)
Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors (2009) (93)
The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. (2001) (93)
Role of Gas6 in erythropoiesis and anemia in mice. (2008) (92)
Sites of erythropoietin production. (1997) (90)
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. (2011) (90)
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. (1994) (90)
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation (2011) (89)
Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. (2007) (86)
Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts (2012) (85)
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. (2002) (85)
Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. (2004) (80)
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin (2018) (80)
Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. (2008) (78)
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. (2012) (77)
VHL inactivation induces HEF1 and Aurora kinase A. (2010) (75)
Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis. (2006) (73)
The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. (1997) (73)
Expression of Hypoxia-Inducible Factor-1 (cid:1) and -2 (cid:1) in Hypoxic and Ischemic Rat Kidneys (2002) (70)
Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. (2000) (69)
Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. (2010) (69)
HIF, a missing link between metabolism and cancer (2005) (68)
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity (2022) (65)
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (64)
Targeting tumors through the HIF system (2000) (60)
Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families (2005) (56)
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR (2014) (56)
HIF-1’s Relationship to Oxygen: Simple yet Sophisticated (2004) (55)
Expression of Hypoxia-Inducible Factors in Normal Human Lung Development (2008) (54)
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors (2016) (53)
The HIF pathway: implications for patterns of gene expression in cancer. (2001) (53)
Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis? (2007) (51)
Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination (2013) (51)
Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats (2013) (50)
Organ-Specific Collagen Expression: Implications for Renal Disease (2005) (49)
The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity* (2013) (48)
Oxygen regulated gene expression: erythropoietin as a model system. (1997) (47)
Regulation of the erythropoietin gene. (1995) (47)
Ty1 Mobilizes Subtelomeric Y′ Elements in Telomerase-Negative Saccharomyces cerevisiae Survivors (2004) (46)
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation (2008) (45)
Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene. (2004) (44)
Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension. (2011) (43)
HIF and oxygen sensing; as important to life as the air we breathe? (2003) (43)
Effects of VHL deficiency on endolymphatic duct and sac. (2005) (43)
Mutations in mitochondrial DNA causing tubulointerstitial kidney disease (2017) (42)
Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons (2006) (40)
Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis (2011) (40)
Recurrence of Complement Factor H-Related Protein 5 Nephropathy in a Renal Transplant (2010) (38)
Cell transcriptomic atlas of the non-human primate Macaca fascicularis (2021) (38)
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis (2006) (37)
Hypoxia and oxidative stress in breast cancer: Hypoxia signalling pathways (2001) (36)
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. (2004) (36)
Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. (2002) (35)
Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor* (2001) (35)
Host Factors That Control Long Terminal Repeat Retrotransposons in Saccharomyces cerevisiae: Implications for Regulation of Mammalian Retroviruses (2007) (35)
Variations within oxygen-regulated gene expression in humans (2008) (34)
A common pathway for genetic events leading to pheochromocytoma. (2005) (34)
Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia (2007) (34)
The role of HIF in immunity. (2010) (34)
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage (2022) (33)
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. (2012) (33)
Hypoxia and B cells. (2017) (32)
Inadvertent postdialysis anticoagulation due to heparin line locks (2007) (32)
The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. (2004) (32)
Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine (2017) (31)
Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20) (2016) (30)
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells (2011) (30)
Developmentally arrested structures preceding cerebellar tumors in von Hippel–Lindau disease (2011) (30)
Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element (2012) (30)
Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease. (2008) (29)
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development (2020) (29)
Preferential retrotransposition in aging yeast mother cells is correlated with increased genome instability. (2015) (29)
Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences. (2013) (28)
Retrosequence formation restructures the yeast genome. (2007) (27)
Insights into the Role of the von Hippel-Lindau Gene Product (2001) (25)
What might retrotransposons teach us about aging? (2016) (25)
Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19 (2020) (25)
VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function (2018) (23)
Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α) (1998) (23)
Oxygen homeostasis and cancer: insights from a rare disease. (2002) (23)
Renal cyst formation in Fh 1-deficient mice is independent of the Hif / Phd pathway (2011) (23)
A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen (2016) (22)
Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms (2011) (21)
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development (2012) (21)
Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression (2009) (20)
Rrm3 Protects the Saccharomyces cerevisiae Genome From Instability at Nascent Sites of Retrotransposition (2009) (20)
Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. (2008) (20)
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes (2021) (19)
C3 glomerulonephritis and CFHR5 nephropathy. (2013) (19)
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. (2002) (19)
Independence of HIF1a and androgen signaling pathways in prostate cancer (2019) (18)
Evidence for hypoxia‐induced neuronal‐to‐chromaffin metaplasia in neuroblastoma (2003) (18)
Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma (2016) (18)
Incidence of End-Stage Renal Disease in the Turkish-Cypriot Population of Northern Cyprus: A Population Based Study (2013) (18)
Copy number profiling in von hippel‐lindau disease renal cell carcinoma (2011) (18)
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population (2017) (17)
Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1* (2017) (16)
Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species (2014) (16)
Dent Disease in Chinese Children and Findings from Heterozygous Mothers: Phenotypic Heterogeneity, Fetal Growth, and 10 Novel Mutations. (2016) (15)
A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib (2009) (14)
Genetic Studies of IgA Nephropathy (2005) (14)
Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy. (2006) (14)
Microchimeric Fetal Cells Are Recruited to Maternal Kidney following Injury and Activate Collagen Type I Transcription (2010) (14)
Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues (2011) (13)
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor (2017) (13)
Regulation of gene expression by oxygen levels in mammalian cells. (1999) (13)
Epigenetic regulation of HIF-1 alpha in renal cancer cells involves HIF-1 alpha/2 alpha binding to a reverse hypoxia-response element (2012) (12)
An Oxygen and Metal Responsive Transcription Factor (2004) (12)
The impact of hypoxia on B cells in COVID-19 (2021) (12)
Recurrence of autonomous hyperparathyroidism in dialysis patients. (1997) (12)
Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence (2018) (11)
The ERA-EDTA Working Group on inherited kidney disorders. (2012) (11)
Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective (2020) (11)
Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells. (2009) (10)
Differentiation in Neuroblastoma: Diffusion-Limited Hypoxia Induces Neuro-Endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype (2010) (10)
Incorporation of Y′-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants (2008) (9)
Cardiopulmonary phenotype associated with human PHD2 mutation (2017) (9)
Beyond erythropoietin: the oxygen sensor. (1997) (9)
Nasty shock after an anti-emetic. (2001) (8)
Low oxygen stimulates the intellect (2006) (8)
Epistatic Role of the MYH9/APOL1 Region on Familial Hematuria Genes (2013) (8)
Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation (2005) (8)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies (2015) (8)
Human CHCHD 4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression (2018) (7)
Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition (2016) (7)
Genetic insights into the hypoxia-inducible factor (HIF) pathway. (2007) (7)
Dialysis Survivors: Clinical Status of Patients on Treatment for More than 10 Years (2008) (6)
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae (2014) (6)
A new approach to treating renal anaemia (2019) (6)
Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients. (2010) (5)
Consequences of ongoing retrotransposition in mammalian genomes (2014) (5)
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 (2022) (5)
Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations (2016) (5)
End-stage renal failure associated with congenital deafness (2008) (5)
Haemophilus influenzae as a rare cause of CAPD peritonitis. (1993) (4)
A mutant complement factor H-related 5 protein is associated with familial C3 glomerulonephritis (2009) (4)
Erythropoietin‐producing Cells in Transgenic Mice Expressing SV40 Large T Antigen Directed by Erythropoietin Control Sequences (1994) (4)
Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors. (2020) (3)
The erythropoietin-producing cells. (1996) (3)
Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients (vol 25, pg 1547, 2010) (2010) (3)
MACROPHAGE SKEWING BY PHD 2 HAPLODEFICIENCY PREVENTS ISCHEMIA BY INDUCING ARTERIOGENESIS (2012) (3)
A novel COL 4 A 1 frameshift mutation in familial kidney disease : the importance of the C-terminal NC 1 domain of type IV collagen (2016) (3)
Gene regulation by hypoxia (2000) (2)
Endogenous Erythropoietin is Required to Preserve Retinal Function Following Oxygen-Induced Retinopathy in the Mouse (2010) (2)
Familial erythrocytosis associated with a mutation in the HIF prolyl hydroxylase, PHD2. (2005) (2)
New insights into the regulation of erythropoietin production. (2000) (2)
Correction of severe anaemia using immuno‐regulated gene therapy is achieved by restoring the early erythroblast compartment (2006) (2)
Genome-Wide Analysis Identifies Strong Association Between HLA and IgA Nephropathy (2010) (2)
Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer (2021) (2)
Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation (2011) (2)
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility (2021) (2)
Molecular genetic analysis of TART (telomere-associated retrotransposon) in Drosophila melanogaster (2004) (1)
Erythropoietin: Effects on Haem Biosynthesis (2000) (1)
Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)) (1998) (1)
(sic)HIGH INCIDENCE OF END-STAGE RENAL DISEASE IN THE TURKISH-CYPRIOT POPULATION OF NORTHERN CYPRUS: A POPULATION BASED STUDY. (2012) (1)
The acute hypoxic ventilatory response is augmented in PHD2-deficient mice (2008) (1)
PTEN CAN FUNCTION AS A TUMOR SUPPRESSOR IN CLEAR CELL RENAL CARCINOMA (2009) (1)
Von Hippel-Lindau Expression in the Retinal Pigment Epithelium is Essential for Normal Eye Development and Vascular Homeostasis (2010) (1)
Preferential Ty1 retromobility in mother cells and nonquiescent stationary phase cells is associated with increased concentrations of total Gag or processed Gag and is inhibited by exposure to a high concentration of calcium (2018) (1)
Developmental and tissue-specific accumulation pattern for the Drosophila melanogaster TART ORF1 protein. (2008) (1)
Response to ‘Hepcidin levels in patients with renal disease’ (2009) (1)
Xenon Preconditioning Protects against Renal Ischemic-Reperfusion Injury via HIF-1 (cid:1) Activation (2009) (1)
Genetic Contribution to IgA Nephropathy (2009) (1)
Critical Amplification by Gas6 of the Epo-Dependent Erythropoietic Response to Anemia: Novel Opportunities for Anemia Treatment. (2004) (1)
A 'GAIN-OF-FUNCTION' MUTATION IN THE HYPOXIA-INDUCIBLE FACTOR 2 alpha GENE DOES NOT REDUCE EXERCISE CAPACITY IN HUMANS (2009) (1)
Regulation of HIF-1 by oxygen: The role of prolyl hydroxylase and the VHL tumor suppressor (2003) (1)
Renal Carcinomas in Clear Cell α Overexpression of Hypoxia-inducible Factor-1 Constitutive Activation of Hypoxia-inducible Genes Related to Updated Version (2001) (0)
Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine (2017) (0)
SP014A NOVEL COL4A1 FRAMESHIFT MUTATION AND KIDNEY DISEASE WITHOUT EXTRA-RENAL INVOLVEMENT IN A LARGE TURKISH CYPRIOT FAMILY (2015) (0)
Increasing evidence that genetic variation in Complement factor H related 5 (CFHR5) causes disease: A commentary on ‘Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene’ (2012) (0)
Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants (1999) (0)
Towards a primate single-cell atlas (2022) (0)
Administration of dimethyloxalylglycine (Dmog) as a novel gastrointestinal repair strategy (2007) (0)
Corrigendum: VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function (2021) (0)
Hepcidin levels in patients with renal disease Response (2009) (0)
Contents Vol. 102, 2006 (2006) (0)
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin (2018) (0)
Contents Vol. 193, 2011 (2011) (0)
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development (2020) (0)
Hypoxia signalling and VHL (2008) (0)
Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development (2021) (0)
Severe COVID-19 and Rheumatoid Arthritis share pro-inflammatory SPP 1 myeloid pathway P . 12 (2021) (0)
Ultrastructural characterization of erythropoietin producing cells in the kidney and liver using transgenic mice (1994) (0)
Atorvastatin protects vascular endothelium from complement-mediated ischaemia-reperfusion injury by upregulation of complement regulatory proteins (2003) (0)
POS-02.84: Vasculogenic mimicry in renal cell carcinoma (2007) (0)
Single-cell atlas of a non-human primate reveals new pathogenic (2020) (0)
Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex (2002) (0)
Genetic and structural analyses suggest that a novel SPG3A mutation causes severe phenotypes of hereditary spastic paraplegia (2006) (0)
Fibroblast-like cells in renal injury show phenotypic changes and hare reduced potential for erythropoietin gene expression. (1999) (0)
HIF-1in humans: potential for involvement of Desferrioxamine elevates pulmonary vascular (2015) (0)
Analysis of VHL tumour suppressor gene (TSG) targets in sporadic and familial renal cell carcinoma (RCC) (2003) (0)
Renal Cell Carcinoma HIF-2 in von Hippel-Lindau-Associated Hypoxia-Inducible Factor 1 ( HIF-1 ) and Contrasting Properties of (2005) (0)
Subject Index Vol. 102, 2006 (2006) (0)
Corrigendum: Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. (2021) (0)
Isolated upregulation of hypoxia-inducible factor 2?? does not consistently reduce exercise capacity in humans (2010) (0)
Hypoxia-Responsive Elements (1997) (0)
Expression and distribution of hypoxia inducible transcription factors in mouse liver, heart and kidney (2006) (0)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies (2015) (0)
Effect of hypoxia on reporter gene expression in various cell lines Hypoxic Cells Species and type % 02 induction Hep 3 B Human hepatoma (2005) (0)
inhibition by prolyl hydroxylase domain inhibitors Complement C 1 q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target that stabilize hypoxia-inducible factor (2017) (0)
Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective (2020) (0)
CAN-10-1949 Cancer esearch cular and Cellular Pathobiology ression Profiling in Progressive Stages of Fumarate-ratase Deficiency : The Contribution of Metabolic R nges to Tumorigenesis (2010) (0)
622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells (2005) (0)
Hypoxia-inducible factor and renal disorders (2015) (0)
Megsin 2093TT Genotype Is Associated With A Protective Role In Iga Nephropathy (2003) (0)
erythropoietin gene therapy Long-term reversal of chronic anemia using a hypoxia-regulated (2013) (0)
Hif hydroxylase inhibitors for anemia treatment (2003) (0)
Oxygen Sensing in the Retina: Hypoxia Induces Contrasting Tissue Distributions of the Hypoxia Inducible Factors Hif-1 And Hif-2 (2008) (0)
SET1B facilitates activation of the hypoxia response through site-specific histone methylation (2020) (0)
Air pollution levels impact on numbers of hospital admissions with acute vaso-occlusive sickle cell pain (2006) (0)
Expression of Hypoxia-inducible Factors in Human Renal Cancer : Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation 1 (2002) (0)
What might retrotransposons teach us about aging? (2015) (0)
Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations (2016) (0)
Hypoxia inducible factor 1 alpha confers androgen independence in prostate cancer (2018) (0)
Oxygen-regulated gene expression in mammalian cells (1997) (0)
UPREGULATION OF MEMBRANE-BOUND COMPLEMENT REGULATORY PROTEINS BY ATORVASTATIN PROTECTS VASCULAR ENDOTHELIUM AGAINST COMPLEMENT-MEDIATED INJURY DURING HYPOXIA-REOXYGENATION (2004) (0)
HIF prolyl hydroxylase inhibitors as treatments for renal anemia and other conditions (2016) (0)
Hypoxia tolerance induced by deficiency of the oxygen sensor PHD1: study of the basel metabolism by MR Spectroscopy (2008) (0)
Molecular basis of renal tumour syndromes (2015) (0)
Phd 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (0)
Functional role of the oxygen sensors PHD1, PHD2 and PHD3: a gene-inactivation study in mice (2006) (0)
Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane (2005) (0)
368: The Cell of Origin of Clear Cell Renal Carcinoma - Re-Visited (2006) (0)
Is it rejection? Be on the lookout for 'decoys'. (2005) (0)
Intracellular proteolysis controlling oxygen responsiveness (2003) (0)
oss or Silencing of the PHD 1 Prolyl Hydroxylase Protects Livers of Mice gainst Ischemia / Reperfusion Injury (0)
3WS15-1 Intracellular proteolysis controlling oxygen responsiveness (2003) (0)
Hypoxia Inducible Factor-1 dependent gene expression in tumours. (1997) (0)
Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3 (2013) (0)
Subject Index Vol. 193, 2011 (2011) (0)
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes (2019) (0)
374: The Identity of the Angiogenic Switch in Renal Cancer (2006) (0)
The von Hippel-Lindau protein: a key player in oxygen homeostasis and matrix assembly (2004) (0)
1028 PTEN CAN FUNCTION AS A TUMOUR SUPPRESSOR IN CLEAR CELL RENAL CARCINOMA (2009) (0)
Inherited Renal Tumour Syndromes (2014) (0)
935 Activation of HIF1α promotes androgen independent prostate cancer cell growth (2013) (0)
Adaptation a l'hypoxie (2009) (0)
Renal Carcinoma and von Hippel–Lindau Disease (2010) (0)
The Molecular Genetics and Pathology of Renal Cell Carcinoma (2010) (0)
Single-cell atlas of a non-human primate reveals new pathogenic 1 mechanisms of COVID-19 2 (2020) (0)
EP-2298: Hypoxia inducible factor 1α confers androgen independence in prostate cancer (2018) (0)
Response to 'The utility of multivariate analysis in the study of hepcidin' (2009) (0)
Loss of prolyl hydroxylase-1 protects in colitis through reduced epithelial cell apoptosis and enhanced barrier function Short Title: PHD1 loss is protective in colitis (0)
INACTIVATION OF THE PHOSPHATASE AND TENSIN HOMOLOG (PTEN) TUMOR SUPPRESSOR CONTRIBUTES TO TUMOR CHARACTERISTICS OF 786-O CLEAR CELL RENAL CARCINOMA CELLS (2008) (0)
Oxygen availability sHIFts the cell cycle (2009) (0)

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