Patrick H. O'Farrell
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Canadian biologist
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Patrick H. O'Farrellbiology Degrees
Biology
#1405
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#2365
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Ecology
#90
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#104
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Biology
Patrick H. O'Farrell's Degrees
- PhD Biology University of British Columbia
- Masters Biology University of British Columbia
- Bachelors Biology University of British Columbia
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Why Is Patrick H. O'Farrell Influential?
(Suggest an Edit or Addition)According to Wikipedia, Patrick H. O'Farrell is a molecular biologist who made crucial contribution to the development of 2-dimensional protein electrophoresis and Drosophila genetics. He is now a professor of Biochemistry at the University of California, San Francisco and has a h-index of 67.
Patrick H. O'Farrell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- High resolution two-dimensional electrophoresis of proteins. (1975) (17430)
- High resolution two-dimensional electrophoresis of basic as well as acidic proteins (1977) (3211)
- Comparative genomics of the eukaryotes. (2000) (1031)
- Faculty Opinions recommendation of Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. (2001) (643)
- Faculty Opinions recommendation of HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. (2001) (591)
- Genetic control of cell division patterns in the Drosophila embryo (1989) (568)
- The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing (2006) (503)
- The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression (1985) (442)
- The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string (1990) (431)
- The sequence specificity of homeodomain-DNA interaction (1988) (416)
- The roles of Drosophila cyclins A and B in mitotic control (1990) (415)
- Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis (1988) (381)
- Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein (1985) (375)
- Expression and function of Drosophila cyclin a during embryonic cell cycle progression (1989) (371)
- Progression of the cell cycle through mitosis leads to abortion of nascent transcripts (1991) (356)
- The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity (1985) (324)
- Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. (1994) (317)
- Identification of Drosophila Gene Products Required for Phagocytosis of Candida albicans (2005) (306)
- Terminal Cytokinesis Events Uncovered after an RNAi Screen (2004) (286)
- Nitric Oxide Contributes to Behavioral, Cellular, and Developmental Responses to Low Oxygen in Drosophila (1999) (258)
- Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. (2003) (258)
- The transcription factor E2F is required for S phase during Drosophila embryogenesis. (1995) (257)
- Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen (2004) (257)
- Active repression of transcription by the engrailed homeodomain protein. (1991) (244)
- Multiple modes of engrailed regulation in the progression towards cell fate determination (1991) (236)
- Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. (1995) (233)
- Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. (1987) (214)
- Triggering the all-or-nothing switch into mitosis. (2001) (198)
- Embryonic Cleavage Cycles: How Is a Mouse Like a Fly? (2004) (194)
- The suppression of defective translation by ppGpp and its role in the stringent response (1978) (193)
- The glucocorticoid domain: Steroid-mediated changes in the rate of synthesis of rat hepatoma proteins (1978) (190)
- Activation and repression of transcription by homoeodomain-containing proteins that bind a common site (1988) (187)
- Directing cell division during development. (1989) (182)
- Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. (1994) (181)
- The state of engrailed expression is not clonally transmitted during early Drosophila development (1992) (177)
- Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells (1977) (174)
- An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins (1991) (161)
- Barriers to male transmission of mitochondrial DNA in sperm development. (2012) (160)
- Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. (1998) (158)
- Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. (1990) (156)
- The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis (2001) (155)
- Two-dimensional polyacrylamide gel electrophoretic fractionation. (1977) (148)
- From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. (2014) (147)
- Rho-dependent control of anillin behavior during cytokinesis (2008) (136)
- The making of a maggot: patterning the Drosophila embryonic epidermis. (1994) (132)
- E2F-induced S phase requires cyclin E. (1996) (128)
- Limb morphogenesis: connections between patterning and growth (1997) (127)
- Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. (1992) (125)
- Fluctuations in Cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila (1998) (125)
- Developmental control of a G1-S transcriptional program in Drosophila. (1994) (120)
- Spatial programming of gene expression in early Drosophila embryogenesis. (1986) (118)
- A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. (1995) (117)
- A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. (1994) (110)
- Mutations of the Drosophila dDP,dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G1-S Transition (1998) (107)
- S-phase function of Drosophila cyclin A and its downregulation in G1 phase (1997) (102)
- Developmental Control of Late Replication and S Phase Length (2010) (101)
- Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. (1988) (100)
- Size control: Cell proliferation does not equal growth (1998) (99)
- Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes (2008) (95)
- Rho-kinase Controls Cell Shape Changes during Cytokinesis (2006) (95)
- Cyclin B Destruction Triggers Changes in Kinetochore Behavior Essential for Successful Anaphase (2003) (91)
- Molecular cloning of engrailed: a gene involved in the development of pattern in drosophila melanogaster (1985) (88)
- Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei (1999) (88)
- Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. (1996) (88)
- Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster (2014) (85)
- Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. (1995) (85)
- A universal target sequence is bound in vitro by diverse homeodomains (1993) (79)
- Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. (1986) (76)
- Hypoxia and Nitric Oxide Induce a Rapid, Reversible Cell Cycle Arrest of the Drosophila Syncytial Divisions* (2001) (74)
- Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. (1995) (73)
- Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. (2000) (72)
- Anillin: a pivotal organizer of the cytokinetic machinery. (2008) (71)
- The cell cycle program in germ cells of the Drosophila embryo. (1998) (70)
- Mechanism and Regulation of Cdc25/Twine Protein Destruction in Embryonic Cell-Cycle Remodeling (2013) (69)
- Drosophila Calcineurin Promotes Induction of Innate Immune Responses (2007) (68)
- Quiescence: early evolutionary origins and universality do not imply uniformity (2011) (67)
- RNAi of Mitotic Cyclins in Drosophila Uncouples the Nuclear and Centrosome Cycle (2008) (65)
- Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View. (2016) (63)
- Nitric oxide‐induced suspended animation promotes survival during hypoxia (2003) (63)
- A Whole-Genome Assembly of Drosophila (2000) (63)
- Separation Techniques Based on the Opposition of Two Counteracting Forces to Produce a Dynamic Equilibrium (1985) (63)
- Cell cycle roles for two 14-3-3 proteins during Drosophila development. (2001) (61)
- The Degradation of Two Mitotic Cyclins Contributes to the Timing of Cytokinesis (2003) (60)
- Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Mitotic Cycles (1997) (58)
- Embryonic onset of late replication requires Cdc25 down-regulation. (2012) (58)
- Qualifying for the license to replicate (1995) (58)
- TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos (2016) (57)
- Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle (1999) (56)
- The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells (1983) (56)
- Drosophila MCM protein complexes. (1996) (56)
- Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events (1999) (54)
- A restriction map of the bacteriophage T4 genome (2004) (54)
- Selfish drive can trump function when animal mitochondrial genomes compete (2016) (53)
- Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation (2003) (53)
- Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Endoreplication Cycles (1998) (53)
- Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed (1989) (53)
- Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin–Cdk complexes (1999) (50)
- Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition (2017) (47)
- Exploring the role of Drosophila cyclin A in the regulation of S phase. (1991) (45)
- Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo (2009) (44)
- Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila (2003) (43)
- Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition (2015) (42)
- Cdks and the Drosophila cell cycle. (1997) (42)
- Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila (2018) (41)
- DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos (2009) (41)
- A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. (1990) (41)
- Illuminating DNA replication during Drosophila development using TALE-lights (2014) (40)
- Isolation and characterization of ColE1-derived plasmid copy-number mutant. (1978) (40)
- The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes (2017) (39)
- Growing an Embryo from a Single Cell: A Hurdle in Animal Life. (2015) (38)
- Selections that isolate recombinant mitochondrial genomes in animals (2015) (38)
- Conserved responses to oxygen deprivation. (2001) (37)
- Connecting Cell Behavior to Patterning: Lessons from the Cell Cycle (1997) (33)
- An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. (2008) (33)
- Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase (1978) (30)
- Nitric oxide synthase is not essential for Drosophila development (2010) (26)
- Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. (2009) (25)
- Big genes and little genes and deadlines for transcription (1992) (25)
- The pre‐omics era: The early days of two‐dimensional gels (2008) (22)
- Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. (1997) (20)
- Sister Chromatids Fail to Separate during an Induced Endoreplication Cycle in Drosophila Embryos (2002) (20)
- A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations (2019) (18)
- Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. (2009) (18)
- Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio (2020) (18)
- Cell cycle control: many ways to skin a cat. (1992) (18)
- Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis (2012) (16)
- The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis. (1994) (16)
- Unanimity waits in the wings (1994) (15)
- The glucocorticoid domain of response: measurement of pleiotropic cellular responses by two-dimensional gel electrophoresis. (1979) (14)
- A consensus of cyclin sequences reveals homology with the ras oncogene. (1991) (14)
- Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. (1983) (13)
- Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis (1985) (13)
- Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research (2017) (12)
- Estrogen binding in the uteri of mammals with delayed implantation. (1971) (11)
- Application of drosophila molecular genetics in the study of neural function — studies of the shaker locus for a potassium channel (1985) (7)
- Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein. (1985) (6)
- Faculty Opinions recommendation of S-nitrosothiols signal the ventilatory response to hypoxia. (2001) (4)
- Biological Applications of Two-Dimensional Gel Electrophoresis (1977) (3)
- Interphase-arrested Drosophila embryos initiate Mid-Blastula Transition at a low nuclear-cytoplasmic ratio (2017) (3)
- Proceedings: Catabolite repression as a pleiotropic response. (1976) (3)
- Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila (2022) (3)
- Mitigation of age-dependent accumulation of defective mitochondrial genomes (2022) (2)
- Chapter 4 Studies of Shaker Mutations Affecting a K+ Channel in Drosophila (1985) (1)
- DNA-polymerase guided elimination of paternal mitochondrial genomes: An escape-proof obstacle to their transmission (2016) (1)
- Mandatory coupling of zygotic transcription to DNA replication in early Drosophila embryos (2022) (1)
- Two-dimensional gel electrophoresis and the beginning of proteomics. (2014) (1)
- Developmental biology. Unanimity waits in the wings. (1994) (1)
- Coordinating transcription and replication to mitigate their conflicts in early Drosophila embryos (2022) (1)
- Patrick H. O'Farrell (2010) (0)
- Live imaging reveals maternally-guided, H3K9me-independent emergence of functional heterochromatin in Drosophila embryos (2016) (0)
- - DmCdc2c: Cdc2 cognate (D. melanogaster) (1995) (0)
- Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription (2022) (0)
- Mitigation of the age-dependent decline in mitochondrial genome integrity (2022) (0)
- Infl uence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo (2009) (0)
- DmCdc2: Cdc2 protein kinase (D. melanogaster) (1995) (0)
- P030. A specialized pathway of innate immune induction triggered by nitric oxide (2006) (0)
- Erratum: Mutations of the drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition (Molecular and Cellular Biology 18:1 (146)) (1998) (0)
- Mutations of the Drosophila dDP, dE2F, andcyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G1-S Transition (1998) (0)
- Infl uence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo (2009) (0)
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