Patrick J. Casey | Academic Influence

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Patrick J. Casey

Biology

#5601

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#8118

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#1906

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Cell Biology

#265

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#273

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#54

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Molecular Biology

#835

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#856

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#182

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Patrick J. Casey

Philosophy

#5838

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#8750

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#1469

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#3048

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#4147

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#660

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Biology
Philosophy

Patrick J. Casey's Degrees

PhD Cancer Biology University of California, San Francisco
Bachelors Biology University of California, Berkeley

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According to Wikipedia, Patrick J. Casey is a biochemist and molecular pharmacologist and is a James B. Duke Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. In 2005, he relocated to Singapore to help found the Duke-NUS Medical School Singapore, where he served as its Senior Vice Dean of Research through July, 2023.

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Patrick J. Casey's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Protein prenylation: molecular mechanisms and functional consequences. (1996) (1982)
Protein lipidation in cell signaling. (1995) (761)
Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides (1990) (701)
p21ras is modified by a farnesyl isoprenoid. (1989) (699)
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. (1992) (652)
G protein involvement in receptor-effector coupling. (1988) (530)
G proteins control diverse pathways of transmembrane signaling 1 (1989) (362)
Post-prenylation-processing enzymes as new targets in oncogenesis (2005) (346)
Protein prenylation: unique fats make their mark on biology (2016) (343)
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation (1995) (325)
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. (1997) (314)
Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution (1997) (301)
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit (1991) (301)
RGS10 is a selective activator of Gαi GTPase activity (1996) (281)
Site-specific analysis of protein S-acylation by resin-assisted capture[S] (2011) (276)
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. (2004) (245)
Gz, a guanine nucleotide-binding protein with unique biochemical properties. (1990) (235)
Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB* (1997) (234)
beta-Catenin is a Nek2 substrate involved in centrosome separation. (2008) (231)
Biochemistry of protein prenylation. (1992) (208)
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. (1987) (195)
Lipid modifications of G proteins. (1994) (194)
Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. (1992) (184)
Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells* (1999) (178)
Rap1 GTPase Inhibits Leukocyte Transmigration by Promoting Endothelial Barrier Function* (2005) (171)
Reaction path of protein farnesyltransferase at atomic resolution (2002) (169)
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. (2005) (169)
Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease* (1999) (162)
Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice* (2001) (162)
G protein gamma subunits contain a 20-carbon isoprenoid. (1990) (161)
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. (2006) (160)
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. (2004) (160)
Enzymology and biology of CaaX protein prenylation. (1999) (155)
Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells* (2000) (153)
Protein Prenyltransferases (*) (1996) (153)
Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate (2003) (143)
Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. (1998) (143)
A Role for the G12 Family of Heterotrimeric G Proteins in Prostate Cancer Invasion* (2006) (143)
Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation (2002) (141)
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. (2005) (138)
Evidence for a Catalytic Role of Zinc in Protein Farnesyltransferase (1997) (137)
RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of Gzα* (1998) (136)
Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. (2007) (135)
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. (1994) (133)
Activation of Rap1 promotes prostate cancer metastasis. (2009) (130)
Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. (1995) (126)
Enzymatic modification of proteins with a geranylgeranyl isoprenoid. (1991) (125)
Overview of the Alliance for Cellular Signaling (2002) (125)
Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. (1992) (124)
Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. (1992) (124)
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. (2001) (121)
Structure of mammalian protein geranylgeranyltransferase type‐I (2003) (119)
Prenylation-dependent Association of Ki-Ras with Microtubules (1997) (118)
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. (2007) (117)
Morphometric differences in sperm head dimensions of fertile and subfertile stallions. (1997) (115)
Identification of a Role for β-Catenin in the Establishment of a Bipolar Mitotic Spindle* (2004) (113)
A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells*♦ (2008) (107)
In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex. (1994) (105)
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. (2005) (103)
Gα12 and Gα13 Negatively Regulate the Adhesive Functions of Cadherin* (2002) (103)
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. (2000) (103)
Quantification of normal head morphometry of stallion spermatozoa. (1996) (102)
Effects of cryopreservation on bull sperm head morphometry. (1998) (98)
Validation of an acrosomal stain for equine sperm that differentiates between living and dead sperm. (1993) (98)
Phosphorylation and Nuclear Translocation of a Regulator of G Protein Signaling (RGS10)* (2001) (96)
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. (1989) (92)
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein (1991) (89)
Pertussis-toxin-sensitive Gα subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex (2005) (89)
The C-terminal Polylysine Region and Methylation of K-Ras Are Critical for the Interaction between K-Ras and Microtubules* (2000) (88)
RGS10 is a selective activator of G alpha i GTPase activity. (1996) (88)
Functional Interaction between Gαz and Rap1GAP Suggests a Novel Form of Cellular Cross-talk* (1999) (88)
H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. (1998) (86)
Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release (2001) (84)
Phosphorylation of Gzα by Protein Kinase C Blocks Interaction with the βγ Complex (*) (1995) (84)
MicroRNA-182 and MicroRNA-200a Control G-protein Subunit α-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells (2013) (82)
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. (1987) (81)
High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. (1993) (80)
Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. (1991) (80)
cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. (1994) (79)
The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells (*) (1996) (77)
Androgen Receptor Activation by Gs Signaling in Prostate Cancer Cells* (2005) (75)
Phosphorylation of Gz in human platelets. Selectivity and site of modification. (1991) (74)
High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors* (2003) (74)
Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase* (1997) (73)
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells (2015) (71)
Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. (1995) (71)
Computer automated morphometric analysis of bull sperm heads. (1996) (70)
Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases (2013) (67)
A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity* (2006) (66)
On the Physiological Importance of Endoproteolysis of CAAX Proteins (2004) (66)
Activation of Gz Attenuates Rap1-mediated Differentiation of PC12 Cells* (2002) (65)
Role of G12 proteins in oncogenesis and metastasis (2009) (65)
The role of prenylation in G-protein assembly and function. (1996) (64)
IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat. (1999) (62)
Computer automated sperm head morphometry analysis (ASMA) of goat spermatozoa. (1995) (60)
Computer-assisted sperm head morphometry analysis (ASMA) of cryopreserved ram spermatozoa. (1998) (54)
Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. (1994) (54)
Identification of a Cysteine Residue Essential for Activity of Protein Farnesyltransferase (1996) (52)
Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. (2002) (52)
Distinct Regions of the Cadherin Cytoplasmic Domain Are Essential for Functional Interaction with Gα12 and β-Catenin* (2001) (51)
Automated morphometric analysis of stallion spermatozoa. (1993) (51)
Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. (1996) (50)
Growth hormone (GH) therapy markedly increases the motility of spermatozoa and the concentration of insulin-like growth factor-I in seminal vesicle fluid in the male GH-deficient dwarf rat. (1996) (50)
GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. (2016) (50)
Arachidonate and Related Unsaturated Fatty Acids Selectively Inactivate the Guanine Nucleotide-binding Regulatory Protein, G(*) (1996) (49)
EFFECTS OF PITUITARY HORMONES AND NADPH ON ACETATE UTILIZATION IN OVARIAN AND ADRENOCORTICAL TISSUES. (1964) (49)
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. (2003) (48)
Pharmacological Targeting of the Mitochondrial Phosphatase PTPMT1 (2010) (48)
The effects of cryopreservation on the morphometric dimensions of caprine sperm heads. (1997) (47)
An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo (2014) (47)
Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. (1992) (45)
Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats. (1997) (45)
Rho GTPase activity modulates Wnt3a/beta-catenin signaling. (2009) (44)
The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with Gα12 but Not Gα13 (2006) (42)
The Interaction of RGSZ1 with SCG10 Attenuates the Ability of SCG10 to Promote Microtubule Disassembly* (2002) (42)
A Role for Gz in Pancreatic Islet β-Cell Biology* (2005) (42)
Microsomal membranes contain a high affinity binding site for prenylated peptides. (1993) (42)
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes (2014) (42)
Pre-freeze bull sperm head morphometry related to post-thaw fertility. (2009) (42)
Gαz Negatively Regulates Insulin Secretion and Glucose Clearance* (2008) (41)
Characterization of Prenylcysteines That Interact with P-glycoprotein and Inhibit Drug Transport in Tumor Cells (*) (1995) (41)
The effect of combined arterial hemodynamics on saphenous venous endothelial nitric oxide production. (2001) (40)
Isolation and Characterization of a Prenylcysteine Lyase from Bovine Brain* (1997) (40)
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2 (2014) (40)
Role of G proteins in transmembrane signaling. (1988) (39)
Role of Isoprenylcysteine Carboxylmethyltransferase-catalyzed Methylation in Rho Function and Migration* (2009) (38)
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms (2017) (37)
Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. (2010) (37)
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. (2009) (36)
Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase. (1998) (36)
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt) (2004) (36)
Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation* (2010) (36)
Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer (2017) (36)
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers (2017) (35)
Reciprocal Signaling between the Transcriptional Co-Factor Eya2 and Specific Members of the Gαi Family (2004) (35)
Lysosomal Prenylcysteine Lyase Is a FAD-dependent Thioether Oxidase* (2001) (35)
Sperm head morphometry analysis of ejaculate and dismount stallion semen samples. (1997) (35)
Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass* (2012) (35)
Conversion of protein farnesyltransferase to a geranylgeranyltransferase. (2006) (34)
A Role for Rac3 GTPase in the Regulation of Autophagy* (2011) (34)
Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1. (2001) (34)
Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. (1996) (34)
Mechanisms of protein prenylation and role in G protein function. (1995) (33)
Prenylated C17orf37 Induces Filopodia Formation to Promote Cell Migration and Metastasis* (2011) (33)
Replicate and technician variation associated with computer aided bull sperm head morphometry analysis (ASMA). (1999) (33)
Cyclosporin A--a chemoprotectant against microcystin-LR toxicity. (1990) (32)
A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator (2010) (31)
Radioisotope dilution technique for determination of vitamin B12 in foods. (1982) (31)
Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. (2002) (30)
Selective Uncoupling of Gα12 from Rho-mediated Signaling* (2005) (30)
Cloning, Expression, and Cellular Localization of a Human Prenylcysteine Lyase* (1999) (30)
Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. (1994) (30)
Structural characterization of prenyl groups attached to proteins (1990) (29)
Blood plasma concentrations of insulin-like growth factor-I (IGF-I) in resting standardbred horses. (2002) (28)
Prenylation and G protein signaling. (1994) (27)
Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe (2009) (27)
Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate. (1987) (26)
Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. (2006) (25)
Therapy with growth hormone: major prospects for the treatment of male subfertility? (1998) (25)
p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress (2019) (25)
Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis (2017) (24)
Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion. (2005) (24)
A role for G(z) in pancreatic islet beta-cell biology. (2005) (23)
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. (2007) (23)
Horse plasma lactate determinations: comparison of wet and dry chemistry methods and the effect of storage. (1996) (23)
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). (2013) (23)
Subtype-specific binding of azidoanilido-GTP by purified G protein alpha subunits. (1994) (23)
The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. (2006) (22)
Prenylcysteine Lyase Deficiency in Mice Results in the Accumulation of Farnesylcysteine and Geranylgeranylcysteine in Brain and Liver* (2002) (21)
G12 Signaling through c-Jun NH2-Terminal Kinase Promotes Breast Cancer Cell Invasion (2011) (21)
Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. (2008) (21)
Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin. (2001) (21)
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. (2006) (21)
The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. (2010) (21)
[2] Isolation of protein prenyltransferases from bovine brain and baculovirus expression system (1995) (20)
Stereospecificity and Kinetic Mechanism of Human Prenylcysteine Lyase, an Unusual Thioether Oxidase* 210 (2002) (19)
Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. (2001) (16)
Column separation of motile sperm from stallion semen. (1993) (15)
The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes (2011) (15)
The G 12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis (2006) (15)
RHO methylation matters (2011) (15)
Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers (2019) (15)
Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions. (1996) (14)
Protein Geranylgeranyltransferase Type 1 as a Target in Cancer. (2016) (14)
The involvement of growth hormone in equine oocyte maturation, receptor localization and steroid production by cumulus-oocyte complexes in vitro. (2013) (13)
ROLE OF VITAMIN A IN GAMMA GLOBULIN BIOSYNTHESIS AND URIC ACID METABOLISM OF MONGOLOIDS. (1964) (13)
Control of RhoA Methylation by Carboxylesterase I* (2013) (13)
Progesterone Does Not Inhibit Aggression Induced by Testosterone Metabolites in Castrated Male Mice (1996) (13)
Lysine164α of protein farnesyltransferase is important for both CaaX substrate binding and catalysis (2001) (12)
Biochemical and morphological correlation of oxidant-induced pulmonary injury: low dose exposure to paraquat, oxygen, and ozone. (1979) (12)
Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. (2004) (12)
1 Mechanism of catalysis by protein farnesyltransferase (2001) (12)
Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. (1991) (12)
Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates. (1986) (11)
PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. (2009) (11)
Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. (2000) (11)
Inhibition of adenylosuccinate lyase by L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (alanosyl-AICOR). (1987) (11)
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. (2007) (10)
Gαz regulates BDNF-induction of axon growth in cortical neurons (2014) (10)
Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal (2020) (9)
Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB (2019) (9)
Percentage of normal sperm heads is significantly increased by Percoll separation of semen. (2002) (9)
Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. (2004) (9)
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells (2017) (9)
Interacting Targets of the Farnesyl of Transducin γ-Subunit (2008) (9)
Enhanced Bovine Colostrum Supplementation Shortens the Duration of Respiratory Disease in Thoroughbred Yearlings (2016) (9)
Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia. (2016) (9)
Prenylation of CaaX-type proteins: Basic principles through clinical applications (2002) (8)
Testicular and spermatozoan parameters in the pukeko (Porphyrio porphyrio melanotus). (2008) (8)
Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif) (2017) (8)
Signaling Through Gz (2009) (8)
The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins. (2016) (8)
Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. (2001) (7)
Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. (2004) (7)
The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors (2021) (7)
NEGATIVELY REGULATES INSULIN SECRETION AND GLUCOSE CLEARANCE * (2007) (6)
Evaluating the Epithelial-Mesenchymal Program in Human Breast Epithelial Cells Cultured in Soft Agar Using a Novel Macromolecule Extraction Protocol (2021) (6)
Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. (1995) (6)
G protein y subunits contain a 20-carbon isoprenoid (2004) (5)
Bovine Colostrum Supplementation Does Not Influence Serum Insulin-like Growth Factor-1 in Horses in Race Training (2014) (5)
Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds (2014) (4)
RHO GTPASE ACTIVITY MODULATES WNT3A/ β -CATENIN SIGNALING (2009) (4)
A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell (2008) (4)
A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. (2009) (4)
Prenylated peptides in identification of specific binding proteins. (1995) (3)
Review of the Current Status of Thresholds/Withdrawal Time Guidelines for Therapeutic Medications in Performance Horses (2008) (3)
Chemical Analysis of Fatty Acids Covalently Attached to Proteins (1988) (3)
The effects of bovine recombinant growth hormone administration on insulin-like growth factor-I and the haemopoietic system in thoroughbred geldings. (2000) (2)
Chapter 1 – The Enzymology of CAAX Protein Prenylation (2011) (2)
Lipid Modifications of GTP-Binding Regulatory Proteins (1993) (1)
Phosphorylation of G z (cid:97) by Protein Kinase C Blocks Interaction with the (cid:98)(cid:103) Complex* (1995) (1)
Expression of Mammalian Protein Farnesyltransferase in a Baculovirus System (1994) (1)
G-Protein Subunit Lipidation in Membrane Association and Signaling (1993) (1)
Isoprenylcysteine carboxylmethyltransferase as a target for development of novel cancer therapeutics (2006) (1)
Dynamite methods:Heterotrimeric G Proteins (Methods Enzymol. 237) edited by R. Iyengar, Academic Press, 1994. $89.00/£68.00 (561 pages) ISBN 0 12 1821382 (1995) (1)
Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters? (1997) (1)
The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I (2001) (1)
Heterotrimeric G Proteins (Methods Enzymol. 237) edited by R. Iyengar, Academic Press, 1994. $89.00/£68.00 (561 pages) ISBN 0 12 1821382 (1995) (1)
Abstract 1371: Isoprenylcysteine carboxylmethyltransferase (ICMT) function is critical for epithelial malignant transformation by mutant-Ras (2017) (0)
The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I 2 (2019) (0)
Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a RRCVLL Peptide Derived from Cdc42 splice isoform-2 (2004) (0)
Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. (2000) (0)
A Role for Gαz in regulating seizure susceptibility (2019) (0)
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE (2001) (0)
Identification of Regulators and Targets of G Protein α Subunits Using the Yeast Two-Hybrid System (2020) (0)
(cid:1) -Catenin is a Nek2 substrate involved in centrosome separation (2007) (0)
Acute effects of paraquat and ozone on cytochrome-dependent enzyme systems in the lung (1978) (0)
Methode de traitement des infections provoquees par le virus de l'hepatite delta (1996) (0)
Chapter 219 - Signaling Through G z (2003) (0)
Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate (2003) (0)
Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a FREKKFFCAIL Peptide Derived from the Heterotrimeric G Protein Gamma-2 Subunit (2004) (0)
RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation (2022) (0)
p2lras is modified by a farnesyl isoprenoid (palmitate/transformation/carboxyl-terminal processing/membrane (0)
Role of Farnesylation of Transducin in Rod Photoreceptor Cells (2004) (0)
Abstract 2339: Targeting ICMT in pancreatic cancer (2018) (0)
Abstract LB-278: MicroRNA control of GNA13 expression and cancer cell invasion (2012) (0)
Poly-ADP ribose polymerase inhibition in a murine model of thoracic aortic ischemia reperfusion: Renal and cardiac benefits (2004) (0)
Abstract A28: DEAD-box RNA helicase DP103 enhances YAP sumoylation for YAP-TEAD dependence and statin sensitivity in triple-negative breast cancer (2020) (0)
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair (2021) (0)
Microsoft Word-JBC revised version (2008) (0)
Therapy with Growth Hormone : Major Prospects for the pY wit Treatment of Male Subfertility ? (0)
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY (2002) (0)
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells (2015) (0)
[8] Assays for G protein βγ subunit activity (1996) (0)
CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION (2000) (0)
Transition State Model of the Protein Farnesyltransferase Reaction Based on Crystal Structures of Protein Farnesyltransferase With Bound Substrates and Products (2002) (0)
Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide (2003) (0)
Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide Derived from K-Ras4B (2004) (0)
Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substrates (2002) (0)
CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750 (2001) (0)
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE (2001) (0)
Targeting Isoprenylcysteine Carboxyl Methyltransferase to Overcome Resistance and Improve Responses in Chronic Myeloid Leukemia. (2009) (0)
Enzymatic modification ofproteins witha geranylgeranyl isoprenoid (1991) (0)
Abstract 2505: GNA13 induction of stemness and resistance to chemotherapy in breast and head and neck cancers (2016) (0)
Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product (2003) (0)
Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a GCINCCKVL Peptide Derived from RhoB (2004) (0)
Prenylation of the hepatitis delta virus large antigen (1996) (0)
Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors (2017) (0)
Pharmacological Inhibition of Protein Geranylgeranyltransferase Type I (GGTase–I) by GGTI–DU40 Increases Aqueous Humor Outflow in Perfused Porcine Eyes (2006) (0)
Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate KKSKTKCVIF Peptide Derived from TC21 (2004) (0)
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYLATED K-RAS4B PEPTIDE PRODUCT (2002) (0)
Analogues of cysmethynil that demonstrate improved isoprenylcysteine carboxymethyltransferase (Icmt) inhibition activity and antiproliferative activity in MDA‐MB‐231 breast cancer cells (2009) (0)
Development of cellular models and small GTPases-targeted therapeutics for inflammatory breast cancer (2006) (0)
Impact of G{alpha}z on axon growth and synaptic transmission (2008) (0)
Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A Resolution (2004) (0)
Human protein farnesyltransferase complexed with L-778,123 and FPP (2004) (0)
The effects of Gαz signaling on pancreatic β‐cell function and mass (2012) (0)
Negatively Regulate the Adhesive Functions of Cadherin * (2002) (0)
Protein farnesyltransferase, beta subunit (2004) (0)

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