Paul David Van Helden
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Paul David Van Heldenbiology Degrees
Biology
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Microbiology
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Genetics
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Molecular Biology
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Biology
Paul David Van Helden's Degrees
- PhD Molecular Biology Stellenbosch University
- Masters Microbiology Stellenbosch University
- Bachelors Microbiology Stellenbosch University
Why Is Paul David Van Helden Influential?
(Suggest an Edit or Addition)Paul David Van Helden's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology (2006) (1068)
- Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. (1999) (648)
- The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. (2017) (447)
- Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. (2005) (441)
- Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions (2006) (397)
- Mycobacterium bovis at the animal-human interface: a problem, or not? (2010) (335)
- Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. (2000) (324)
- Zoonotic Mycobacterium bovis–induced Tuberculosis in Humans (2013) (317)
- Patients with active tuberculosis often have different strains in the same sputum specimen. (2004) (311)
- Drug resistance in Mycobacterium tuberculosis. (2006) (294)
- Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference. (2006) (286)
- A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance (2009) (250)
- Novel Mycobacterium tuberculosis Complex Pathogen, M. mungi (2010) (247)
- Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. (2013) (222)
- Hypomethylation of DNA in pathological conditions of the human prostate. (1987) (221)
- Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children. (2006) (220)
- A Recently Evolved Sublineage of the Mycobacterium tuberculosis Beijing Strain Family Is Associated with an Increased Ability to Spread and Cause Disease (2007) (219)
- Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area (2003) (217)
- Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis (2006) (215)
- Trimodality of isoniazid elimination: phenotype and genotype in patients with tuberculosis. (1997) (189)
- Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears (2007) (186)
- Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission (2012) (185)
- Analysis for a Limited Number of Gene Codons Can Predict Drug Resistance of Mycobacterium tuberculosis in a High-Incidence Community (2001) (182)
- Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study (2013) (181)
- Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns. (2005) (180)
- Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report (2009) (177)
- An Evaluation of Commercial Fluorescent Bead-Based Luminex Cytokine Assays (2008) (171)
- Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux. (2011) (168)
- Microevolution of the Direct Repeat Region of Mycobacterium tuberculosis: Implications for Interpretation of Spoligotyping Data (2002) (168)
- Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control (2012) (166)
- Isoniazid pharmacokinetics in children treated for respiratory tuberculosis (2005) (158)
- Emergence of Increased Resistance and Extensively Drug-Resistant Tuberculosis Despite Treatment Adherence, South Africa (2010) (158)
- Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis. (2007) (157)
- Mycobacterium tuberculosis Beijing genotype: a template for success. (2011) (156)
- Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene. (2003) (152)
- Transmission of tuberculosis in a high incidence urban community in South Africa. (2004) (152)
- The global burden of tuberculosis--combating drug resistance in difficult times. (2009) (152)
- Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis (2009) (149)
- Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (2014) (144)
- Stability of Variable-Number Tandem Repeats of Mycobacterial Interspersed Repetitive Units from 12 Loci in Serial Isolates of Mycobacterium tuberculosis (2002) (143)
- The human immune response to tuberculosis and its treatment: a view from the blood (2015) (143)
- Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function. (2013) (141)
- The role of IS6110 in the evolution of Mycobacterium tuberculosis. (2007) (127)
- Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture. (2010) (125)
- Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB (2016) (124)
- Danish bacille Calmette-Guérin vaccine-induced disease in human immunodeficiency virus-infected children. (2003) (124)
- Spoligotype Signatures in the Mycobacterium tuberculosis Complex (2006) (123)
- Baseline sputum time to detection predicts month two culture conversion and relapse in non-HIV-infected patients. (2010) (121)
- Impact of social interactions in the community on the transmission of tuberculosis in a high incidence area (1999) (118)
- Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis (2008) (118)
- Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy. (2015) (118)
- Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis (2014) (117)
- African 1, an Epidemiologically Important Clonal Complex of Mycobacterium bovis Dominant in Mali, Nigeria, Cameroon, and Chad (2009) (117)
- Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis. (2014) (117)
- Xpert MTB/RIF for Rapid Diagnosis of Tuberculous Lymphadenitis from Fine-Needle-Aspiration Biopsy Specimens (2011) (115)
- Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among noninstitutionalized, human immunodeficiency virus-seronegative patients. (1999) (115)
- The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study. (2014) (114)
- gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis. (2012) (114)
- Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reserves. (2009) (113)
- The Diagnostic Performance of the GenoType MTBDRplus Version 2 Line Probe Assay Is Equivalent to That of the Xpert MTB/RIF Assay (2012) (113)
- A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis (2015) (112)
- Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. (2009) (108)
- Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c. (2001) (107)
- Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis (2014) (103)
- No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers. (1990) (103)
- Drug‐Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis (2018) (100)
- Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission. (2010) (100)
- Adult-to-child transmission of tuberculosis: household or community contact? (2003) (100)
- Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment (2011) (100)
- Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 (2017) (99)
- European 1: a globally important clonal complex of Mycobacterium bovis. (2011) (99)
- Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study. (2017) (98)
- Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients. (2007) (97)
- Beijing and Haarlem Genotypes Are Overrepresented among Children with Drug-Resistant Tuberculosis in the Western Cape Province of South Africa (2006) (95)
- Application of Sensitive and Specific Molecular Methods To Uncover Global Dissemination of the Major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis Spoligotype Family (2008) (94)
- Multiple Mycobacterium tuberculosis Strains in Early Cultures from Patients in a High-Incidence Community Setting (2002) (94)
- African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa (2010) (94)
- Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (2008) (94)
- Papulonecrotic Tuberculid: Identification of Mycobacterium tuberculosis DNA by Polymerase Chain Reaction (1992) (94)
- Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa. (2013) (93)
- Novel Cause of Tuberculosis in Meerkats, South Africa (2013) (93)
- Frequency and implications of pyrazinamide resistance in managing previously treated tuberculosis patients. (2006) (91)
- Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy. (1999) (89)
- Total Antioxidant Levels are Low During Active TB and Rise with Anti‐tuberculosis Therapy (2004) (89)
- Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints (2012) (87)
- Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain. (2010) (85)
- SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa. (2004) (84)
- Unexpectedly high strain diversity of Mycobacterium tuberculosis in a high-incidence community. (1996) (84)
- The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazid. (2004) (83)
- Erythema Induratum of Bazin: A Clinicopathological Study of 20 Cases and Detection of Mycobacterium tuberculosis DNA in Skin Lesions by Polymerase Chain Reaction (1995) (83)
- Bovine tuberculosis in African buffaloes: observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria (2007) (82)
- Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii (2018) (82)
- The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa (2010) (81)
- Ethambutol resistance testing by mutation detection. (2006) (79)
- Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders (2006) (78)
- Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa (2013) (76)
- inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa? (2011) (76)
- Genotypic and Phenotypic Characterization of Drug-Resistant Mycobacterium tuberculosis Isolates from Rural Districts of the Western Cape Province of South Africa (2004) (76)
- Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa. (2012) (76)
- Molecular Characteristics and Global Spread of Mycobacterium tuberculosis with a Western Cape F11 Genotype (2004) (75)
- Safe Mycobacterium tuberculosis DNA Extraction Method That Does Not Compromise Integrity (2006) (75)
- Calculation of the Stability of the IS6110 Banding Pattern in Patients with Persistent Mycobacterium tuberculosis Disease (2002) (74)
- Transmission of multidrug-resistant tuberculosis (2000) (74)
- Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity (2000) (74)
- Time to detection of Mycobacterium tuberculosis in BACTEC systems as a viable alternative to colony counting. (2008) (74)
- Disruption of coding regions by IS6110 insertion in Mycobacterium tuberculosis. (1999) (74)
- Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries (2016) (73)
- Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa. (2007) (72)
- Discordance between Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Typing and IS6110 Restriction Fragment Length Polymorphism Genotyping for Analysis of Mycobacterium tuberculosis Beijing Strains in a Setting of High Incidence of Tuberculosis (2008) (72)
- Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region (2009) (72)
- A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population (2013) (72)
- Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the Black and Colored populations of South Africa. (1999) (71)
- Oligonucleotide (GTG)5 as a marker for Mycobacterium tuberculosis strain identification (1994) (71)
- Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families. (2002) (71)
- Immune markers measured before treatment predict outcome of intensive phase tuberculosis therapy (2006) (69)
- Evolution of the IS6110-Based Restriction Fragment Length Polymorphism Pattern during the Transmission of Mycobacterium tuberculosis (2002) (68)
- Detection of tuberculosis by automatic cough sound analysis (2018) (68)
- The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks (2013) (68)
- Genotype MTBDRsl line probe assay shortens time to diagnosis of extensively drug-resistant tuberculosis in a high-throughput diagnostic laboratory. (2012) (67)
- Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. (2008) (66)
- Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis. (2012) (65)
- An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa. (2006) (65)
- One world, one health (2013) (65)
- Clonal Expansion of a Globally Disseminated Lineage of Mycobacterium tuberculosis with Low IS6110 Copy Numbers (2004) (65)
- Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population. (2009) (64)
- Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis. (2009) (64)
- Population Structure of Multi- and Extensively Drug-Resistant Mycobacterium tuberculosis Strains in South Africa (2011) (64)
- Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration. (2015) (64)
- Using a Label-free Proteomics Method to Identify Differentially Abundant Proteins in Closely Related Hypo- and Hypervirulent Clinical Mycobacterium tuberculosis Beijing Isolates* (2010) (63)
- Mycobacterium tuberculosis Population Structure Determines the Outcome of Genetics-Based Second-Line Drug Resistance Testing (2012) (63)
- Spread of a Low-Fitness Drug-Resistant Mycobacterium tuberculosis Strain in a Setting of High Human Immunodeficiency Virus Prevalence (2008) (63)
- Fluorometric Assay for Testing Rifampin Susceptibility of Mycobacterium tuberculosis Complex (2008) (63)
- Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages (2016) (62)
- Polymerase chain reaction in the diagnosis of tuberculous meningitis. (1993) (61)
- A Threshold Value for the Time Delay to TB Diagnosis (2007) (61)
- Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions (2016) (61)
- High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease. (2010) (61)
- Ergothioneine Is a Secreted Antioxidant in Mycobacterium smegmatis (2013) (60)
- Genotyping of Mycobacterium tuberculosis with additional markers enhances accuracy in epidemiological studies (1996) (59)
- Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family (1997) (59)
- Novel Method for Rapid Measurement of Growth of Mycobacteria in Detergent-Free Media (1998) (58)
- The Effect of Diagnostic Delays on the Drop-Out Rate and the Total Delay to Diagnosis of Tuberculosis (2008) (58)
- Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare (1995) (58)
- Association of esophageal cytological abnormalities with vitamin and lipotrope deficiencies in populations at risk for esophageal cancer. (1988) (57)
- Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children. (2004) (56)
- The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems (2016) (56)
- Alcohol, Hospital Discharge, and Socioeconomic Risk Factors for Default from Multidrug Resistant Tuberculosis Treatment in Rural South Africa: A Retrospective Cohort Study (2013) (56)
- Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area (2012) (56)
- The pyrazinamide susceptibility breakpoint above which combination therapy fails (2014) (56)
- Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya. (2004) (55)
- Programmatically Selected Multidrug-Resistant Strains Drive the Emergence of Extensively Drug-Resistant Tuberculosis in South Africa (2013) (55)
- Mycobacterium paratuberculosis and Crohn's disease. (1995) (55)
- Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania (2013) (55)
- Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. (2015) (55)
- Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents. (2012) (54)
- Purification of sputum samples through sucrose improves detection of Mycobacterium tuberculosis by polymerase chain reaction (1992) (53)
- Gene-gene interaction between tuberculosis candidate genes in a South African population (2011) (52)
- A Novel Inhibitor of Gyrase B Is a Potent Drug Candidate for Treatment of Tuberculosis and Nontuberculosis Mycobacterial Infections (2014) (52)
- p53 and p16/CDKN2 gene mutations in esophageal tumors from a high‐incidence area in South Africa (1998) (51)
- HLA class II disease associations in southern Africa. (2006) (51)
- Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis (2010) (51)
- Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa. (2003) (51)
- Bovine tuberculosis at the human-livestock-wildlife interface: is it a public health problem in Tanzania? A review. (2012) (50)
- Mycobacterium tuberculosis Transmission Is Not Related to Household Genotype in a Setting of High Endemicity (2009) (49)
- Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis. (1997) (49)
- Improved method for the routine identification of toxigenic Escherichia coli by DNA amplification of a conserved region of the heat-labile toxin A subunit (1991) (48)
- Prediction of Drug Resistance in M. tuberculosis: Molecular Mechanisms, Tools, and Applications (2002) (48)
- Papulonecrotic tuberculid in children. A report of eight patients. (1996) (48)
- The diagnostic accuracy of the MTBDRplus and MTBDRsl assays for drug-resistant TB detection when performed on sputum and culture isolates (2016) (48)
- Predominance of a single genotype of Mycobacterium tuberculosis in regions of Southern Africa. (2007) (47)
- Historic and recent events contribute to the disease dynamics of Beijing-like Mycobacterium tuberculosis isolates in a high incidence region. (2002) (47)
- Population Structure of Mixed Mycobacterium tuberculosis Infection Is Strain Genotype and Culture Medium Dependent (2013) (47)
- Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer). (2014) (46)
- Tuberculosis reinfection rate as a proportion of total infection rate correlates with the logarithm of the incidence rate: a mathematical model (2009) (46)
- Laboratory experience and guidelines for avoiding false positive polymerase chain reaction results. (1993) (46)
- Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets. (2014) (46)
- Potential of Rapid Diagnosis for Controlling Drug-Susceptible and Drug-Resistant Tuberculosis in Communities Where Mycobacterium tuberculosis Infections Are Highly Prevalent (2009) (46)
- A rapid method of diagnosing pulmonary tuberculosis using stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry. (2005) (46)
- Use of Genetic Distance as a Measure of Ongoing Transmission of Mycobacterium tuberculosis (2003) (46)
- The clinical relevance of Mycobacterial pharmacogenetics. (2009) (45)
- Evaluation of the AID TB Resistance Line Probe Assay for Rapid Detection of Genetic Alterations Associated with Drug Resistance in Mycobacterium tuberculosis Strains (2014) (45)
- Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy (2016) (43)
- Demonstration of reinfection and reactivation in HIV-negative autopsied cases of secondary tuberculosis: multilesional genotyping of Mycobacterium tuberculosis utilizing IS 6110 and other repetitive element-based DNA fingerprinting. (2001) (43)
- Differences in Primary Sites of Infection between Zoonotic and Human Tuberculosis: Results from a Worldwide Systematic Review (2013) (43)
- Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains (2013) (43)
- A Sensitive Urinary Lipoarabinomannan Test for Tuberculosis (2015) (42)
- INFECTION OF AFRICAN BUFFALO (SYNCERUS CAFFER) BY ORYX BACILLUS, A RARE MEMBER OF THE ANTELOPE CLADE OF THE MYCOBACTERIUM TUBERCULOSIS COMPLEX (2012) (41)
- Isolation of DNA from Mycobacterium tubercolosis. (2001) (41)
- Cross-contamination of human esophageal squamous carcinoma cell lines detected by DNA fingerprint analysis. (1988) (40)
- Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis. (2009) (40)
- Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania (2014) (40)
- Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population (2019) (40)
- Whole genome sequence analysis of Mycobacterium suricattae. (2015) (40)
- ESAT-6 and CFP-10: What Is the Diagnosis? (2002) (40)
- Allografted keratinocytes used to accelerate the treatment of burn wounds are replaced by recipient cells. (1990) (40)
- Determining Ancestry Proportions in Complex Admixture Scenarios in South Africa Using a Novel Proxy Ancestry Selection Method (2013) (39)
- Differential Expression of Interleukin-4 (IL-4) and IL-4δ2 mRNA, but Not Transforming Growth Factor Beta (TGF-β), TGF-βRII, Foxp3, Gamma Interferon, T-bet, or GATA-3 mRNA, in Patients with Fast and Slow Responses to Antituberculosis Treatment (2008) (39)
- Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates. (2010) (39)
- Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa (2018) (39)
- IP-10 Is a Sensitive Biomarker of Antigen Recognition in Whole-Blood Stimulation Assays Used for the Diagnosis of Mycobacterium bovis Infection in African Buffaloes (Syncerus caffer) (2015) (38)
- High Prevalence of Tuberculosis and Insufficient Case Detection in Two Communities in the Western Cape, South Africa (2013) (38)
- SNP/RD Typing of Mycobacterium tuberculosis Beijing Strains Reveals Local and Worldwide Disseminated Clonal Complexes (2011) (38)
- Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer). (2011) (38)
- Sequence Polymorphism in the rrs Gene ofMycobacterium tuberculosis Is Deeply Rooted within an Evolutionary Clade and Is Not Associated with Streptomycin Resistance (2001) (37)
- Phage-based detection of bacterial pathogens. (2014) (37)
- IS6110 Insertions in Mycobacterium tuberculosis: Predominantly into Coding Regions (2001) (37)
- Evidence that the Spread of Mycobacterium tuberculosis Strains with the Beijing Genotype Is Human Population Dependent (2011) (37)
- Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. (2011) (37)
- Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. (2020) (37)
- Medroxyprogesterone Acetate Alters Mycobacterium Bovis BCG-Induced Cytokine Production in Peripheral Blood Mononuclear Cells of Contraceptive Users (2011) (36)
- Regulation of nitrogen metabolism in Mycobacterium tuberculosis: A comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor (2008) (36)
- Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries (2016) (36)
- Detection and treatment of subclinical tuberculosis. (2012) (36)
- Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescents. (2010) (36)
- The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis (2013) (36)
- A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. (2010) (35)
- Selective Requirement for CD40-CD154 in Drug-Induced Type 1 Versus Type 2 Responses to Trinitrophenyl-Ovalbumin1 (2002) (34)
- Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents. (2009) (34)
- Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment (2015) (34)
- Measuring minimum inhibitory concentrations in mycobacteria. (2009) (34)
- The role of ancestry in TB susceptibility of an admixed South African population. (2014) (34)
- Evolution of rifampicin treatment for tuberculosis. (2019) (34)
- Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease. (2014) (34)
- Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT (2015) (33)
- Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study (2010) (33)
- Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis. (2013) (33)
- IS6110-Mediated Deletion Polymorphism in the Direct Repeat Region of Clinical Isolates of Mycobacterium tuberculosis (2003) (32)
- Pulmonary Infection due to Mycobacterium bovis in a Black Rhinoceros (Diceros bicornis minor) in South Africa (2009) (32)
- Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa. (2008) (32)
- Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population. (2007) (32)
- Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting. (2012) (32)
- Use of Spoligotyping for Accurate Classification of Recurrent Tuberculosis (2002) (32)
- Evidence that the Spread of Mycobacterium tuberculosis Strains with the Beijing Genotype Is Human Population Dependent (2007) (32)
- Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment. (2009) (31)
- Antigen-Specific IP-10 Release Is a Sensitive Biomarker of Mycobacterium bovis Infection in Cattle (2016) (31)
- Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions. (2011) (31)
- Length Variation of DC-SIGN and L-SIGN Neck-Region has no Impact on Tuberculosis Susceptibility (2006) (30)
- Independent Large Scale Duplications in Multiple M. tuberculosis Lineages Overlapping the Same Genomic Region (2012) (30)
- The complete amino-acid sequence of histone H2B from the mollusc Patella granatina. (1979) (30)
- Rapid Diagnosis of Pediatric Mycobacterial Lymphadenitis Using Fine Needle Aspiration Biopsy (2014) (29)
- Molecular analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with persistent disease in the Khartoum region of Sudan. (2002) (29)
- Molecular evolution of Mycobacterium tuberculosis: phylogenetic reconstruction of clonal expansion. (2001) (29)
- Antemortem Diagnosis of Mycobacterium bovis Infection in Free-ranging African Lions (Panthera leo) and Implications for Transmission (2015) (28)
- Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA. (2018) (28)
- The Host Response to a Clinical MDR Mycobacterial Strain Cultured in a Detergent-Free Environment: A Global Transcriptomics Approach (2016) (28)
- Bovine TB in livestock and wildlife: what's in the genes? (2013) (28)
- Gene Polymorphisms in African Buffalo Associated with Susceptibility to Bovine Tuberculosis Infection (2013) (27)
- Sulfamethoxazole enhances the antimycobacterial activity of rifampicin. (2012) (27)
- Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. (2017) (27)
- katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent (1996) (27)
- Coding versus intron variability: extremely polymorphic HLA-DRB1 exons are flanked by specific composite microsatellites, even in distant populations (1997) (27)
- Test performance of three serological assays for the detection of Mycobacterium bovis infection in common warthogs (Phacochoerus africanus). (2016) (26)
- Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. (2008) (26)
- Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis (2018) (26)
- Chronic atrophic gastritis, gastric pH, nitrites and micronutrient levels in a population at risk for gastric carcinoma. (1990) (26)
- Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania (2015) (26)
- Creation and characterisation of a high-copy-number version of the pAL5000 mycobacterial replicon. (2007) (26)
- Evaluation of the Capilia TB Assay for Culture Confirmation of Mycobacterium tuberculosis Infections in Zambia and South Africa (2010) (26)
- Age-related methylation changes in DNA may reflect the proliferative potential of organs. (1989) (26)
- Mycobacterium bovis infection in the lion (Panthera leo): Current knowledge, conundrums and research challenges. (2015) (25)
- Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress (2016) (25)
- Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population (2014) (25)
- Gamma-glutamylcysteine protects ergothioneine-deficient Mycobacterium tuberculosis mutants against oxidative and nitrosative stress. (2018) (25)
- Mycobacterium tuberculosis Beijing Genotype Is Associated with HIV Infection in Mozambique (2013) (25)
- Genetic Resistance to Mycobacterium tuberculosis Infection and Disease (2018) (25)
- Histone H2B variants from the erythrocytes of an amphibian, a reptile and a bird. (1978) (24)
- Prevalence and Risk Factors for Mycobacterium bovis Infection in African Lions (Panthera leo) in the Kruger National Park (2017) (24)
- Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence. (2010) (24)
- Tuberculosis cross-species transmission in Tanzania: towards a One-Health concept. (2012) (24)
- Strain families of Mycobacterium tuberculosis. (2002) (24)
- Detecting drug-resistant tuberculosis: the importance of rapid testing. (2011) (24)
- Mycobacterium bovis in a Free-Ranging Black Rhinoceros, Kruger National Park, South Africa, 2016 (2017) (24)
- Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife (2019) (24)
- Mycobacterial nucleoid associated proteins: An added dimension in gene regulation. (2018) (23)
- Absence of an Association Between Mycobacterium tuberculosis Genotype and Clinical Features in Children With Tuberculous Meningitis (2007) (23)
- Conservation of White Rhinoceroses Threatened by Bovine Tuberculosis, South Africa, 2016–2017 (2018) (23)
- Distinct serum biosignatures are associated with different tuberculosis treatment outcomes (2019) (23)
- Antimicrobial resistance in tuberculosis: an international perspective (2006) (22)
- Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population. (2007) (22)
- DETECTION OF ANTIBODIES TO TUBERCULOSIS ANTIGENS IN FREE-RANGING LIONS (PANTHERA LEO) INFECTED WITH MYCOBACTERIUM BOVIS IN KRUGER NATIONAL PARK, SOUTH AFRICA (2012) (22)
- The evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer). (2014) (21)
- IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis (2004) (21)
- Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON‐TB Gold (In‐Tube) assay (2009) (21)
- Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy. (2013) (21)
- Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study (2015) (21)
- The complete genome sequence of the African buffalo (Syncerus caffer) (2016) (21)
- TB: a partnership for the benefit of research and community. (2005) (20)
- Seroprevalence of Mycobacterium bovis infection in warthogs (Phacochoerus africanus) in bovine tuberculosis‐endemic regions of South Africa (2018) (20)
- Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing (2012) (19)
- Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility (2014) (19)
- The Role of Glutamine Oxoglutarate Aminotransferase and Glutamate Dehydrogenase in Nitrogen Metabolism in Mycobacterium bovis BCG (2013) (19)
- Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife (2021) (19)
- 'One Health' infectious diseases surveillance in Tanzania: are we all on board the same flight? (2012) (19)
- Rifampicin resistance in Mycobacterium tuberculosis--rapid detection and implications in chemotherapy. (1996) (19)
- Esophageal cancer: vitamin and lipotrope deficiencies in an at-risk South African population. (1987) (19)
- High Frequency of Resistance, Lack of Clinical Benefit, and Poor Outcomes in Capreomycin Treated South African Patients with Extensively Drug-Resistant Tuberculosis (2015) (19)
- RNAseq reveals hypervirulence-specific host responses to M. tuberculosis infection (2016) (18)
- Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies (2017) (18)
- Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum): Susceptibility, clinical and anatomical pathology (2017) (18)
- The Risk of Tuberculosis Reinfection Soon after Cure of a First Disease Episode Is Extremely High in a Hyperendemic Community (2015) (18)
- Massive Posterior Fossa Tuberculous Abscess Developing in a Young Child Treated for Miliary Tuberculosis (1998) (18)
- The arms race between man and Mycobacterium tuberculosis: Time to regroup. (2017) (18)
- embB306 Mutations as Molecular Indicators to Predict Ethambutol Susceptibility in Mycobacterium tuberculosis (2012) (18)
- Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation (2009) (18)
- Investigating the Role of Gene-Gene Interactions in TB Susceptibility (2015) (18)
- A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array (2018) (18)
- Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer) (2011) (18)
- The cost of research in developing countries (2012) (17)
- TB epidemiology and human genetics. (2006) (17)
- DIAGNOSIS AND IMPLICATIONS OF MYCOBACTERIUM BOVIS INFECTION IN BANDED MONGOOSES (MUNGOS MUNGO) IN THE KRUGER NATIONAL PARK, SOUTH AFRICA (2017) (17)
- Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study (2017) (17)
- NAT2 slow acetylator function as a risk indicator for age-related cataract formation. (2003) (17)
- Rainfall-driven sex-ratio genes in African buffalo suggested by correlations between Y-chromosomal haplotype frequencies and foetal sex ratio (2010) (17)
- The role of human host genetics in tuberculosis resistance (2017) (17)
- Pulmonary Infection Due to Mycobacterium goodii in a Spotted Hyena (Crocuta crocuta) from South Africa (2008) (17)
- Detection of Mycobacterium kansasii infection in a rhesus macaque (Macaca mulatta) using a modified QuantiFERON-TB Gold assay. (2010) (17)
- Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis (2020) (17)
- Moxifloxacin Retains Antimycobacterial Activity in the Presence of gyrA Mutations (2014) (16)
- A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility (2017) (16)
- Oligonucleotide (GTG)5 as an epidemiological tool in the study of nontuberculous mycobacteria (1997) (16)
- Fine-scale human population structure in southern Africa reflects ecological boundaries (2016) (16)
- Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique (2018) (16)
- Mycobacterium bovis Infection in African Wild Dogs, Kruger National Park, South Africa (2019) (16)
- Functional effects of CRP binding to nuclei. (1986) (16)
- Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis. (2016) (16)
- Data‐driven hypotheses (2013) (15)
- The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum) (2017) (15)
- Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates. (2017) (15)
- IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus). (2018) (15)
- Development of a diagnostic gene expression assay for tuberculosis and its use under field conditions in African buffaloes (Syncerus caffer). (2012) (15)
- Effect of milk fermentation by kefir grains and selected single strains of lactic acid bacteria on the survival of Mycobacterium bovis BCG. (2016) (15)
- Differential Expression of Mycothiol Pathway Genes: Are they Affected by Antituberculosis Drugs? (2004) (15)
- A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens (2015) (15)
- Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer). (2019) (15)
- Drug susceptibility testing using molecular techniques can enhance tuberculosis diagnosis. (2008) (14)
- Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer). (2018) (14)
- Optimizing the use of cadavers by integrating pathology during anatomy dissection (2016) (14)
- Reverse zoonotic tuberculosis transmission from an emerging Uganda I strain between pastoralists and cattle in South-Eastern Nigeria (2019) (14)
- The detection of Mycobacterium tuberculosis in bone marrow aspirate using the polymerase chain reaction. (1994) (14)
- Measuring antigen-specific responses in Mycobacterium bovis-infected warthogs (Phacochoerus africanus) using the intradermal tuberculin test (2018) (14)
- Changes in the kinetics of intracellular IFN-gamma production in TB patients during treatment. (2007) (14)
- Criteria for Identification of Cross-Contamination of Cultures of Mycobacterium tuberculosis in Routine Microbiology Laboratories (2003) (14)
- Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis (2021) (13)
- The prevalence of antibodies to Toxoplasma gondii in sheep in the Western Cape, South Africa. (2015) (13)
- Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency (2017) (13)
- The role of molecular epidemiology in low-income, high-burden countries. (2009) (13)
- The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana) (2020) (13)
- The prevalence of antibodies to Toxoplasma gondii in sheep in the Western Cape, South Africa (2015) (13)
- On the nature of genetic changes required for the development of esophageal cancer (2003) (13)
- High yield of culture-based diagnosis in a TB-endemic setting (2012) (13)
- Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes. (2009) (13)
- Second episode of tuberculosis in an HIV-infected child: relapse or reinfection? (2000) (13)
- Combining fine‐needle aspiration biopsy (FNAB) and high‐resolution melt analysis to reduce diagnostic delay in mycobacterial lymphadenitis (2009) (12)
- TB Control in Humans and Animals in South Africa: A Perspective on Problems and Successes (2018) (12)
- An assay for O6-alkylguanine-DNA alkyltransferase based on restriction endonuclease inhibition and magnetic bead separation of products. (1994) (12)
- Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens (2014) (12)
- Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion (2016) (12)
- An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum). (2019) (12)
- The complete amino-acid sequence of histone H2B from erythrocytes of the adult domestic fowl Gallus domesticus. (1982) (12)
- Stability of Polymorphic GC-Rich Repeat Sequence-Containing Regions of Mycobacterium tuberculosis (2004) (12)
- Design, synthesis, and In vitro antituberculosis activity of 2(5H)‐Furanone derivatives (2016) (12)
- Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria (2019) (12)
- Paratuberculosis in a domestic dog in South Africa (2017) (12)
- Isoniazid Resistance and Dosage as Treatment for Patients with Tuberculosis. (2017) (11)
- NAT2 polymorphisms and their influence on the pharmacology and toxicity of isoniazid in TB patients. (2007) (11)
- Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1. (2017) (11)
- Application of Rapid Serologic Tests for Detection of Mycobacterium bovis Infection in Free-Ranging Warthogs (Phacochoerus africanus)—Implications for Antemortem Disease Screening (2016) (11)
- Strain-specific variation in the dnaJ gene of mycobacteria. (1996) (11)
- Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis (2018) (11)
- Proteomic analysis reveals that sulfamethoxazole induces oxidative stress in M. tuberculosis. (2018) (11)
- Molecular Epidemiological Interpretation of the Epidemic of Extensively Drug-Resistant Tuberculosis in South Africa (2015) (11)
- AN INTERFERON GAMMA RELEASE ASSAY FOR THE DETECTION OF IMMUNE SENSITIZATION TO MYCOBACTERIUM BOVIS IN AFRICAN WILD DOGS ( LYCAON PICTUS). (2019) (11)
- Insertion element IS6110-based restriction fragment length polymorphism genotyping of Mycobacterium tuberculosis. (2009) (11)
- Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa (2017) (11)
- Prediction of delayed treatment response in pulmonary tuberculosis: use of time to positivity values of Bactec cultures. (2008) (10)
- Novel Linear Diamine Disubstituted Polycyclic ‘Cage’ Derivatives as Potential Antimycobacterial Candidates (2011) (10)
- High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and in community controls. (2008) (10)
- 'Emerging' mycobacteria in South Africa. (2009) (10)
- Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping (2017) (10)
- Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer). (2019) (10)
- Rv2629 191A/C nucleotide change is not associated with rifampicin resistance in Mycobacterium tuberculosis (2009) (10)
- Characterization of Mycobacterium orygis (2012) (10)
- Context‐dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host (2018) (9)
- Detection of Mutations in Mycobacterium tuberculosis by a Dot Blot Hybridization Strategy. (2001) (9)
- Development and evaluation of a diagnostic cytokine-release assay for Mycobacterium suricattae infection in meerkats (Suricata suricatta) (2016) (9)
- The stability of plasma IP-10 enhances its utility for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer). (2016) (9)
- 1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis. (2021) (9)
- Performance of the Tuberculin Skin Test in Mycobacterium bovis-Exposed and -Unexposed African Lions ( Panthera leo). (2019) (9)
- Detection by DNA fingerprinting of somatic changes during the establishment of a new prostate cell line. (1994) (9)
- Correction: Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa (2013) (9)
- Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes (2017) (9)
- Evidence for transcriptional regulation of the myosin heavy chain gene during myogenesis. (1984) (8)
- Antigen-specific interferon-gamma release is decreased following the single intradermal comparative cervical skin test in African buffaloes (Syncerus caffer). (2018) (8)
- Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa (2017) (8)
- Generation and characterization of thiol-deficient Mycobacterium tuberculosis mutants (2018) (8)
- A commercial ELISA for detection of interferon gamma in white rhinoceros (2019) (8)
- A regulatory variant in the C1Q gene cluster is associated with tuberculosis susceptibility and C1qA plasma levels in a South African population (2020) (8)
- The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer) (2020) (8)
- The economic divide and tuberculosis. Tuberculosis is not just a medical problem, but also a problem of social inequality and poverty. (2003) (8)
- Mycobacterium bovis Infection in Free-Ranging African Elephants (2021) (8)
- Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion. (2016) (7)
- Mycobacterium africanum is not a major cause of human tuberculosis in Cape Town, South Africa. (2010) (7)
- Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus) (2018) (7)
- Potential Z-DNA-forming elements in serum DNA from human systemic lupus erythematosus. (1985) (7)
- High diversity, inbreeding and a dynamic Pleistocene demographic history revealed by African buffalo genomes (2021) (7)
- DNA fingerprint detection of somatic mutations in benign prostatic hyperplasia and prostatic adenocarcinoma (1996) (7)
- Predicting reinfection in tuberculosis. (2008) (7)
- Baseline Hematologic Results for Free-ranging White Rhinoceros (Ceratotherium simum) in Kruger National Park, South Africa (2015) (7)
- Optimisation of the tuberculin skin test for detection of Mycobacterium bovis in African buffaloes (Syncerus caffer). (2021) (6)
- High Seroprevalence of Toxoplasma gondii in an Urban Caracal ( Caracal caracal) Population in South Africa. (2019) (6)
- Molecular Epidemiology of TB: Challenging Dogmas and Asking New Questions (2002) (6)
- Complex evolutionary history of felid anelloviruses. (2021) (6)
- Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages (2016) (6)
- Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting. (2019) (6)
- The "Source" of Drug-Resistant TB Outbreaks (2006) (6)
- A new TB vaccine: fact or fiction? (2013) (6)
- A method to analyze allele-specific methylation. (1990) (6)
- O(6)-alkylguanine-DNA alkyltransferase DNA repair in mycobacteria: pathogenic and non-pathogenic species differ. (2002) (6)
- Cytokine gene expression assay as a diagnostic tool for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus) (2019) (6)
- Test Characteristics of Assays to Detect Mycobacterium bovis Infection in High-Prevalence African Buffalo (Syncerus caffer) Herds (2019) (6)
- Autoantibodies from patients with systemic lupus erythematosus can affect DNA and RNA synthesis in cultured cells. (1989) (6)
- Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci (2021) (6)
- Empirical Evaluation of Conditions Influencing the Polymerase Chain Reaction: Enterotoxigenic Escherichia coli as a Test Case (1993) (5)
- Novel molecular transport medium used in combination with Xpert MTB/RIF ultra provides rapid detection of Mycobacterium bovis in African buffaloes (2021) (5)
- Improved detection of Mycobacterium tuberculosis and M. bovis in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation (2021) (5)
- Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations. (2009) (5)
- A new assay for anti-DNA antibodies in serum which includes the measurement of anti-Z-DNA. (1987) (5)
- Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies. (2021) (5)
- Pathogens of Vertebrate Animals as Invasive Species: Insights from South Africa (2020) (5)
- Comparative Analysis of a Putative Tuberculosis-Susceptibility Gene, MC3R, and Pseudogene Sequences in Cattle, African Buffalo, Hyena, Rhinoceros and Other African Bovids and Ruminants (2012) (4)
- Identification of a novel WAS mutation in a South African patient presenting with atypical Wiskott-Aldrich syndrome: a case report (2020) (4)
- Diagnosis of Mycobacterium bovis Infection in Free-Ranging Common Hippopotamus (Hippopotamus amphibius). (2021) (4)
- Factors influencing peak expiratory flow in teenage boys. (2001) (4)
- Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis (2018) (4)
- Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing. (2013) (4)
- Positive Selection of Deleterious Alleles through Interaction with a Sex-Ratio Suppressor Gene in African Buffalo: A Plausible New Mechanism for a High Frequency Anomaly (2014) (4)
- Multilaboratory Evaluation of a Novel Lateral Flow Immunochromatographic Assay for Confirming Isolation of Mycobacterium bovis from Veterinary Diagnostic Specimens (2017) (4)
- Diagnostic accuracy of the FluoroType MTB and MTBDR VER 2.0 assays for the centralised high throughput detection of Mycobacterium tuberculosis complex DNA and isoniazid and rifampicin resistance. (2021) (4)
- Correction: Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area (2012) (3)
- Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host (2019) (3)
- A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort. (2021) (3)
- Adaptation, redundancy or resilience (2011) (3)
- Rapid genomic diversification of Helicobacter pylori (1999) (3)
- A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort (2020) (3)
- Selective breeding: the future of TB management in African buffalo? (2015) (3)
- Effects of adriamycin on heart and skeletal muscle chromatin. (1982) (3)
- Bacterial genetics and strain variation. (1998) (3)
- Use of the MILLIPLEX® bovine cytokine/chemokine multiplex assay to identify Mycobacterium bovis-infection biomarkers in African buffaloes (Syncerus caffer). (2020) (3)
- Naturally occurring anti-DNA antibodies from systemic lupus erythematosus patients may be used to study gene expression in vitro. (1988) (2)
- One Health approach in the prevention and control of mycobacterial infections in Tanzania: lessons learnt and future perspectives (2019) (2)
- Tuberculosis Infection: Occurrence and Risk Factors in Presumptive Tuberculosis Patients of the Serengeti Ecosystem in Tanzania (2017) (2)
- Toll-like receptor (TLR) diversity influences mycobacterial growth in African buffalo. (2017) (2)
- African wild dogs (Lycaon pictus) from the Kruger National Park, South Africa are currently not inbred but have low genomic diversity (2022) (2)
- Not too much and not too little (2012) (2)
- Molecular answers to tuberculous questions. (2000) (2)
- The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems (2016) (2)
- The economic divide and tuberculosis (2003) (2)
- Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Mycobacterium bovis Infection in African Lions (Panthera leo) (2022) (2)
- Adequacy of 6-month follow-up in chemotherapy trials. (2010) (1)
- Correction: The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks (2015) (1)
- Analysis of allele-specific methylation. (1990) (1)
- Cytokine biomarker discovery in the white rhinoceros (Ceratotherium simum). (2020) (1)
- Shedding of Mycobacterium bovis in respiratory secretions of free-ranging wild dogs (Lycaon pictus): Implications for intraspecies transmission. (2021) (1)
- A theoretical consideration of the lysine-rich histones: H1 from a mammal and an echinoderm, H5 from erythrocytes. (1982) (1)
- The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots. (2003) (1)
- Reconsidering global targets for tuberculosis control. (2009) (1)
- CYTOKINE-RELEASE ASSAY FOR THE DETECTION OF MYCOBACTERIUM BOVIS INFECTION IN CHEETAH (ACINONYX JUBATUS) (2021) (1)
- Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient (2018) (1)
- A pilot study evaluating the utility of commercially available antibodies for flow cytometric analysis of Panthera species lymphocytes (2018) (1)
- Use of (35)s nucleotides for DNA sequencing. (1988) (1)
- Papanicolaou induced fluorescence, Ziehl‐Neelsen and Auramine O stains on lymph node fine needle aspiration biopsy specimens from children: A comparative study (2018) (1)
- Mycobacterial Interspersed Repetitive-Unit–Variable-Number Tandem-Repeat Analysis and Beijing/W Family of Mycobacterium tuberculosis (2011) (1)
- The subunit structure of heart muscle chalones. (1982) (1)
- Towards Eliminating Bias in Cluster Analysis of TB Genotyped Data (2012) (1)
- The effect of adriamycin on Z-DNA formation and DNA synthesis. (1983) (0)
- Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis (2020) (0)
- The influence of primary structure changes on the higher order structure of histone H2B. (1980) (0)
- African wild dogs (Lycaon pictus) from the Kruger National Park, South Africa are currently not inbred but have low genomic diversity (2022) (0)
- Population structure and infectious disease risk in southern Africa (2017) (0)
- Use of elutips to purify DNA. (1988) (0)
- Deciphering Genetic Susceptibility to Tuberculous Meningitis (2016) (0)
- Corrigendum to "Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA" [J. Vet. Immunol. Immunopathol. 196 (2018) 48-52]. (2018) (0)
- Science and ethics review: the thrill is gone (2012) (0)
- Plasmid preparation on sephacryl s1000. (1988) (0)
- Algorithms and surrogate markers in translational research (2011) (0)
- Managing academic research (2010) (0)
- Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping (2017) (0)
- Mycobacterium tuberculosis: concentrate resources on recent infections (2019) (0)
- African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa (2012) (0)
- Comparison of interferon gamma release assay and CXCL9 gene expression assay for the detection of Mycobacterium bovis infection in African lions (Panthera leo) (2022) (0)
- Simplicity (2012) (0)
- The complete genome sequence of the African buffalo (Syncerus caffer) (2016) (0)
- Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis (2018) (0)
- Preliminary investigation of a new serum marker for ovarian cancer (2012) (0)
- Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population (2014) (0)
- Histone H1(0): a maintainer of the differentiated cell state? (1985) (0)
- Treasure our rarities (2011) (0)
- Is bigger better? (2010) (0)
- Water (2011) (0)
- Development of a cytokine gene expression assay for the relative quantification of the African elephant (Loxodonta africana) cell-mediated immune responses. (2021) (0)
- Spoligotype Signatures in the Mycobacterium tuberculosis Complex (2007) (0)
- A highly divergent mitochondrial genome in extant Cape buffalo from Addo Elephant National Park, South Africa (2023) (0)
- Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens (2014) (0)
- Mannose-binding lectin and meningococcal disease. (1999) (0)
- Incidence of heat-labile enterotoxin-producing Escherichia coli detected by means of polymerase chain reaction amplification. (1994) (0)
- Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus) (2018) (0)
- Zoonotic Mycobacterium bovis–induced Tuberculosis in Humans (2013) (0)
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