Paul Greengard
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American neuroscientist
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Biology
#107
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#195
Historical Rank
#61
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#25
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Biology
Paul Greengard's Degrees
- PhD Biophysics Johns Hopkins University
Why Is Paul Greengard Influential?
(Suggest an Edit or Addition)According to Wikipedia, Paul Greengard was an American neuroscientist best known for his work on the molecular and cellular function of neurons. In 2000, Greengard, Arvid Carlsson and Eric Kandel were awarded the Nobel Prize for Physiology or Medicine for their discoveries concerning signal transduction in the nervous system. He was Vincent Astor Professor at Rockefeller University, and served on the Scientific Advisory Board of the Cure Alzheimer's Fund, as well as the Scientific Council of the Brain & Behavior Research Foundation. He was married to artist Ursula von Rydingsvard.
Paul Greengard's Published Works
Published Works
- Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004) (2174)
- Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. (2000) (1308)
- Synaptic vesicle phosphoproteins and regulation of synaptic function. (1993) (1271)
- Advances in Cyclic Nucleotide Research (1973) (1255)
- Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation (1983) (1134)
- Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity (2008) (1067)
- A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types (2008) (1029)
- Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor". (1972) (965)
- Regulation of NMDA receptor trafficking by amyloid-β (2005) (925)
- Intraneuronal Aβ42 Accumulation in Human Brain (2000) (860)
- Phosphorylated proteins as physiological effectors. (1978) (854)
- The neurobiology of slow synaptic transmission. (2001) (851)
- Regulation of NMDA receptor trafficking by amyloid-beta. (2005) (827)
- A 38,000-dalton membrane protein (p38) present in synaptic vesicles. (1985) (788)
- Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1 (1995) (775)
- GSK-3-selective inhibitors derived from Tyrian purple indirubins. (2003) (773)
- Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia (2003) (773)
- Beyond the Dopamine Receptor the DARPP-32/Protein Phosphatase-1 Cascade (1999) (763)
- Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. (2002) (722)
- IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. (2012) (680)
- DARPP-32: an integrator of neurotransmission. (2004) (672)
- Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells (1986) (658)
- Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters† (1976) (649)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization (1984) (614)
- Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity (2010) (610)
- Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. (2005) (608)
- Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? (2001) (606)
- Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. (1969) (606)
- Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types (2009) (594)
- Pharmacological inhibitors of glycogen synthase kinase 3. (2004) (592)
- Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. (1985) (591)
- DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1 (1984) (585)
- Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. (1992) (562)
- Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons (1999) (562)
- Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons (1995) (555)
- Synapsins as mediators of BDNF-enhanced neurotransmitter release (2000) (554)
- Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States (2006) (539)
- Synapsins as regulators of neurotransmitter release. (1999) (532)
- Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections (1983) (526)
- Protein Phosphorylation and Neuronal Function (1985) (508)
- Pharmacological inhibitors of cyclin-dependent kinases. (2002) (508)
- Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes (1983) (501)
- Protein kinases in the brain. (1985) (500)
- Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types (2008) (496)
- The Neurobiology of Dopamine Signaling (2001) (489)
- DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission (1998) (487)
- Distinct pools of synaptic vesicles in neurotransmitter release (1995) (487)
- Cerebellar neurodegeneration in the absence of microRNAs (2007) (483)
- Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons (1991) (479)
- Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5 (2001) (477)
- Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein. (1975) (467)
- Intraneuronal Abeta42 accumulation in human brain. (2000) (464)
- Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C (1985) (460)
- Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. (1990) (442)
- Chaperones increase association of tau protein with microtubules (2003) (440)
- Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. (1997) (440)
- Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling (2001) (433)
- Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons (2000) (424)
- Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. (1994) (422)
- Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs. (1974) (417)
- Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. (1969) (414)
- Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in l-DOPA-Induced Dyskinesia (2007) (414)
- Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides (1998) (411)
- Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine (1997) (408)
- Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. (1996) (402)
- Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium (1988) (398)
- Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. (1999) (396)
- Protein phosphorylation in the brain (1980) (394)
- Protein phosphorylation in the nervous system (1984) (393)
- Spinophilin regulates the formation and function of dendritic spines. (2000) (386)
- Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses (2005) (380)
- Synapsin I bundles F-actin in a phosphorylation-dependent manner (1987) (375)
- Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission (1971) (375)
- Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization (1986) (374)
- Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity (2000) (373)
- Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices (1990) (367)
- Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. (1994) (366)
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. (2004) (349)
- A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr 32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor (1998) (345)
- Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice (2004) (344)
- The route of absorption of intraperitoneally administered compounds. (1971) (344)
- Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP) (2014) (343)
- Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. (1992) (343)
- Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase. (1984) (341)
- Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. (2000) (338)
- Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. (2006) (335)
- cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. (1986) (335)
- Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation (1987) (334)
- Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. (1995) (331)
- Synapsin dispersion and reclustering during synaptic activity (2001) (331)
- A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions (1983) (325)
- Different Presynaptic Roles of Synapsins at Excitatory and Inhibitory Synapses (2004) (325)
- Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. (1972) (325)
- Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors (2010) (323)
- Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. (1980) (316)
- Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. (1977) (315)
- Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and Psychostimulants In Vivo (2000) (313)
- Regulation by synapsin I and Ca(2+)‐calmodulin‐dependent protein kinase II of the transmitter release in squid giant synapse. (1991) (311)
- Diverse Psychotomimetics Act Through a Common Signaling Pathway (2003) (310)
- Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology (2006) (310)
- Synaptic Vesicle Mobilization Is Regulated by Distinct Synapsin I Phosphorylation Pathways at Different Frequencies (2003) (309)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain (1984) (306)
- Phosphorylation of the catalytic subunit of Na+,K(+)-ATPase inhibits the activity of the enzyme. (1991) (305)
- Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix (2007) (305)
- Does insulin dysfunction play a role in Alzheimer's disease? (2002) (304)
- Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein. (1977) (302)
- Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex (2009) (300)
- Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. (2000) (298)
- Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. (2000) (297)
- Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin (1999) (297)
- Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. (1993) (295)
- Inhibition by dopamine of (Na+ + K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism (1990) (295)
- Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation (2007) (292)
- Phosphorylation of the cystic fibrosis transmembrane conductance regulator. (1992) (291)
- Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein (1978) (288)
- Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. (1972) (288)
- A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. (1987) (286)
- Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. (2002) (285)
- Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. (1997) (285)
- Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. (1981) (284)
- Characterization of synapsin I binding to small synaptic vesicles. (1986) (279)
- Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator". (1978) (275)
- Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. (1970) (275)
- Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes (1989) (271)
- Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity (2008) (266)
- Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3':5'-monophosphate. (1973) (266)
- Type 1 Phosphatase, a Negative Regulator of Cardiac Function (2002) (265)
- Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies (2007) (264)
- Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I (1992) (263)
- Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain. (1984) (263)
- Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans (2011) (262)
- Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease (2010) (261)
- Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. (1994) (260)
- The Alzheimer Amyloid Precursor Protein (APP) and Fe65, an APP-Binding Protein, Regulate Cell Movement (2001) (258)
- Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l-DOPA–Induced Dyskinesia (2009) (255)
- Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit (2007) (253)
- Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites. (1981) (252)
- Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes (1990) (251)
- Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. (1980) (250)
- Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. (1972) (249)
- Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5 (2003) (248)
- IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity (2011) (245)
- Activation/deactivation of renal Na+,K+‐ATPase: a final common pathway for regulation of natriuresis (1994) (243)
- Phorbol Ester Enhancement of Neurotransmitter Release from Rat Brain Synaptosomes (1987) (242)
- Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum (2008) (242)
- Amplification of dopaminergic signaling by a positive feedback loop. (2000) (241)
- Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation (1988) (241)
- MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice (2013) (240)
- Regulation of β-Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein* (1999) (240)
- Brain histamine receptors as targets for antidepressant drugs (1978) (240)
- Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. (1985) (238)
- Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton (2002) (238)
- Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. (1989) (238)
- Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. (1995) (238)
- Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5 (2000) (236)
- The hypothalamic arcuate nucleus-median eminence complex: Immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons (1986) (235)
- Adenosine 3',5'-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission (1972) (233)
- Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker (1984) (231)
- Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. (1994) (230)
- Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II. (1986) (229)
- Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac) (2002) (229)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution (1986) (229)
- Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2 (1990) (228)
- Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs (2008) (228)
- Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. (1980) (228)
- Synapsins in the vertebrate retina: Absence from ribbon synapses and heterogeneous distribution among conventional synapses (1990) (226)
- Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. (1979) (226)
- D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. (1999) (224)
- Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes. (1982) (223)
- Cocaine Increases Dopamine Release by Mobilization of a Synapsin-Dependent Reserve Pool (2006) (223)
- A phosphatase cascade by which rewarding stimuli control nucleosomal response (2008) (222)
- Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. (2004) (221)
- Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia (2014) (219)
- A third member of the synapsin gene family. (1998) (217)
- A quantitative dot-immunobinding assay for proteins using nitrocellulose membrane filters. (1984) (215)
- Colocalization of synapsin and actin during synaptic vesicle recycling (2003) (214)
- Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. (1984) (211)
- Octopamine-Sensitive Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous Tissue (1973) (211)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus (1984) (211)
- A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization (1983) (209)
- Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. (1993) (208)
- A small‐molecule enhancer of autophagy decreases levels of Aβ and APP‐CTF via Atg5‐dependent autophagy pathway (2011) (207)
- Histamine-sensitive adenylate cyclase in mammalian brain (1976) (205)
- Neuronal phosphoproteins: physiological and clinical implications. (1984) (203)
- Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. (1997) (202)
- Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. (1988) (201)
- Advances in Cyclic Nucleotide and Protein Phosphorylation Research (1975) (201)
- Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites (2003) (200)
- Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. (1989) (200)
- Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. (2000) (198)
- Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. (1992) (197)
- Cyclic Nucleotides, Phosphorylated Proteins, And Neuronal Function (1978) (196)
- Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. (1994) (196)
- The Amyloid Precursor Protein and Its Regulatory Protein, FE65, in Growth Cones and Synapses In Vitro and In Vivo (2003) (196)
- Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. (1984) (195)
- Estrogen increases the number of spinophilin‐immunoreactive spines in the hippocampus of young and aged female rhesus monkeys (2003) (194)
- Adenosine 3',5'-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission (1971) (193)
- Role of cyclic AMP in synaptic transmission in the mammalian peripheral nervous system. (1974) (192)
- Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems (2013) (191)
- Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. (1990) (191)
- Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys. (2004) (191)
- Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen (1998) (191)
- Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity. (1996) (190)
- Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy (2013) (189)
- CHARACTERIZATION OF A DOPAMINE‐SENSITIVE ADENYLATE CYCLASE IN THE RAT CAUDATE NUCLEUS (1975) (189)
- Synapsin I in nerve terminals: selective association with small synaptic vesicles. (1984) (188)
- Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. (1990) (187)
- An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli. (1969) (186)
- Opposing Changes in Phosphorylation of Specific Sites in Synapsin I During Ca2+-Dependent Glutamate Release in Isolated Nerve Terminals (2001) (186)
- Regional distribution of calcium- and cyclic adenosine 3':5'- monophosphate-regulated protein phosphorylation systems in mammalian brain. II. Soluble systems (1983) (186)
- On the mode of action of local anesthetics. (1966) (185)
- Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells. (1992) (185)
- Mammalian brain phosphoproteins as substrates for calcineurin. (1984) (184)
- Mechanisms of Locomotor Sensitization to Drugs of Abuse in a Two-Injection Protocol (2010) (184)
- Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases. (1981) (182)
- Stimulus-dependent myristoylation of a major substrate for protein kinase C (1988) (179)
- Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. (1998) (179)
- Role of protein phosphorylation in neuronal signal transduction 1 (1989) (179)
- l‐DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice (2009) (177)
- Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein (1994) (176)
- Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update (2014) (176)
- Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61 (2010) (175)
- Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia (1982) (175)
- FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity (2008) (175)
- Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase (1979) (174)
- Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb (1991) (173)
- Purification and characterization of Ca2+/calmodulin-dependent protein kinase I from bovine brain. (1987) (171)
- Gleevec inhibits β-amyloid production but not Notch cleavage (2003) (171)
- Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease (2014) (171)
- Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model (2010) (171)
- DARPP-32 mediates the actions of multiple drugs of abuse (2005) (171)
- Regulated Formation of Golgi Secretory Vesicles Containing Alzheimer β-Amyloid Precursor Protein (*) (1995) (170)
- Interactions of synapsin I with small synaptic vesicles: distinct sites in synapsin I bind to vesicle phospholipids and vesicle proteins (1989) (169)
- Synaptic vesicle recycling in synapsin I knock-out mice (1996) (168)
- Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine (2002) (168)
- Inhibition of Mitochondrial Complex II Induces a Long-Term Potentiation of NMDA-Mediated Synaptic Excitation in the Striatum Requiring Endogenous Dopamine (2001) (165)
- Structure and function of the synapsins. (1992) (165)
- Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation (2007) (164)
- Differential expression of protein phosphatase 1 isoforms in mammalian brain (1995) (164)
- Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins. (2001) (164)
- Hormone-Sensitive Adenyl Cyclase: Cytochemical Localization in Rat Liver (1970) (162)
- Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation (2002) (162)
- D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. (2000) (161)
- 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase. (1997) (158)
- The DARPP-32/protein phosphatase-1 cascade: a model for signal integration 1 Published on the World Wide Web on 22 January 1998. 1 (1998) (157)
- Cyclic nucleotide-dependent protein kinases. V. Preparation and properties of adenosine 3',5'-monophosphate-dependent protein kinase from various bovine tissues. (1970) (157)
- The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate* (2001) (156)
- Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. (2002) (155)
- Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. (2004) (155)
- Uptake of tyrosine by rat brain in vivo. (1960) (154)
- Isolation and Characterization of PNUTS, a Putative Protein Phosphatase 1 Nuclear Targeting Subunit* (1998) (154)
- Evidence for phosphorylation and oligomeric assembly of presenilin 1. (1997) (153)
- Evidence for involvement of protein kinase in the activation by adenosine 3':5'-monophosphate of brain tyrosine 3-monooxygenase. (1975) (153)
- Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. (1993) (152)
- Role of cyclic AMP in cell function (1970) (152)
- On the active structure of local anesthetics. (1965) (152)
- Subcellular distribution of adenosine 3',5'-monophosphate-dependent protein kinase in rat brain. (1971) (152)
- Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition (2010) (151)
- Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. (1989) (151)
- Phosphorylation of endogenous protein of rat brain by cyclic adenosine 3',5'-monophosphate-dependent protein kinase. (1971) (151)
- Cyclic 3',5'-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral Cortex (1971) (150)
- Synapsin I: a synaptic vesicle-associated neuronal phosphoprotein. (1986) (150)
- cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor. (1983) (149)
- Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy (1995) (149)
- M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia (2015) (149)
- Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors (2005) (149)
- The Rho-Specific GEF Lfc Interacts with Neurabin and Spinophilin to Regulate Dendritic Spine Morphology (2005) (149)
- Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell (1978) (148)
- Regulation of Alzheimer's disease amyloid-β formation by casein kinase I (2007) (148)
- The synapsins. (1990) (148)
- Regulation of DARPP‐32 dephosphorylation at PKA‐ and Cdk5‐sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase‐2A (2002) (147)
- The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses. (1997) (146)
- Mechanism of action of benzodiazepines (1975) (146)
- A protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth (2002) (146)
- Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method. (2016) (145)
- Protein tyrosine phosphorylation in synaptic vesicles. (1988) (145)
- Two sites of action for synapsin domain E in regulating neurotransmitter release (1998) (145)
- cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones (1986) (145)
- Role of p11 in Cellular and Behavioral Effects of 5-HT4 Receptor Stimulation (2009) (145)
- Dissociation and activation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases by cyclic nucleotides and by substrate proteins. (1973) (144)
- Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals. (1989) (144)
- Primate sperm contain protein phosphatase 1, a biochemical mediator of motility. (1996) (144)
- Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors (2004) (143)
- Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. (1978) (143)
- Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. (1994) (143)
- Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses (1992) (142)
- Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. (1987) (142)
- Regulation of Neurotransmitter Release by Synapsin III (2002) (142)
- Interaction of free and synaptic vesicle-bound synapsin I with F-actin (1992) (141)
- Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling (2003) (140)
- Adenosine 3',5-monophosphate-dependent phosphorylation of a specific protein in synaptic membrane fractions from rat cerebrum. (1972) (140)
- Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation (1999) (139)
- Opposite regulation by typical and atypical anti‐psychotics of ERK1/2, CREB and Elk‐1 phosphorylation in mouse dorsal striatum (2003) (139)
- Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior (2012) (138)
- HORMONE‐SENSITIVE ION TRANSPORT SYSTEMS IN ERYTHROCYTES AS MODELS FOR EPITHELIAL ION PATHWAYS (1981) (137)
- Climate change and the integrity of science. (2010) (137)
- Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein* (2003) (136)
- p11 and its role in depression and therapeutic responses to antidepressants (2013) (135)
- Cyclic nucleotide-dependent protein kinases. IX. Partial purification and some properties of guanosine 3',5'-monophosphate-dependent and adenosine 3',5'-monophosphate-dependent protein kinases from various tissues and species of Arthropoda. (1971) (135)
- Cellular and molecular basis for stress-induced depression (2016) (135)
- Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors (2006) (134)
- Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine (2007) (134)
- cAMP-stimulated cation cotransport in avian erythrocytes: inhibition by "loop" diuretics. (1980) (134)
- Regulation by steroid hormones of phosphorylation of specific protein common to several target organs. (1976) (134)
- Identification, characterization, and quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a photoaffinity ligand. (1977) (133)
- Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin. (1992) (132)
- Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity. (1988) (131)
- Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum (2004) (131)
- Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine (1992) (131)
- Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity inAplysia (2001) (130)
- Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction (2010) (130)
- Photoaffinity labeling of a protein kinase from bovine brain with 8-azidoadenosine 3',5'-monophosphate. (1975) (129)
- Structural Domains Involved in the Regulation of Transmitter Release by Synapsins (2005) (129)
- Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. (2005) (129)
- The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. (1995) (128)
- Estrogen Lowers Alzheimer β-Amyloid Generation by Stimulatingtrans-Golgi Network Vesicle Biogenesis* (2002) (128)
- Characterization of the Inhibition of Protein Phosphatase-1 by DARPP-32 and Inhibitor-2* (1999) (128)
- Identification of the Cortical Neurons that Mediate Antidepressant Responses (2012) (128)
- Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons (1998) (127)
- Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers (1989) (127)
- Molecular Determinants of Synapsin Targeting to Presynaptic Terminals (2004) (127)
- Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease (2020) (127)
- Development of a dopamine- and cyclic adenosine 3':5'-monophosphate- regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation (1987) (127)
- Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling (2009) (127)
- Distribution of DARPP-32 in the basal ganglia: an electron microscopic study (1990) (126)
- The role of DARPP-32 in the actions of drugs of abuse (2004) (126)
- Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. (2008) (126)
- Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors (2001) (126)
- cGMP-Dependent Protein Kinase in Dorsal Root Ganglion: Relationship with Nitric Oxide Synthase and Nociceptive Neurons (1996) (126)
- Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation. (1984) (126)
- Production of phosphorylation state-specific antibodies. (1991) (126)
- An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum (1978) (126)
- Synaptophysin (p38) at the frog neuromuscular junction: its incorporation into the axolemma and recycling after intense quantal secretion (1988) (126)
- Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes (1989) (125)
- Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane. (1998) (124)
- DARPP-32 mediates serotonergic neurotransmission in the forebrain (2002) (123)
- Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens (2009) (123)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1. (1984) (123)
- Generation and Regulation of β‐Amyloid Peptide Variants by Neurons (1998) (122)
- Synapsin III: Developmental Expression, Subcellular Localization, and Role in Axon Formation (2000) (122)
- Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines (2006) (122)
- Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens (2010) (122)
- Phosphodiesterase 1B Knock-Out Mice Exhibit Exaggerated Locomotor Hyperactivity and DARPP-32 Phosphorylation in Response to Dopamine Agonists and Display Impaired Spatial Learning (2002) (122)
- Phosphoprotein phosphatases from rat cerebral cortex. Subcellular distribution and characterization. (1972) (121)
- Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in l-DOPA treatment of an animal model of Parkinsonism (2008) (120)
- Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. (1999) (120)
- The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells (1997) (120)
- Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase. (1980) (120)
- Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain (1990) (119)
- Distinct Roles of Synapsin I and Synapsin II during Neuronal Development (1998) (119)
- Cdk5 is essential for adult hippocampal neurogenesis (2008) (119)
- Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. (2000) (119)
- Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses (1995) (118)
- Widespread occurrence of "87 kDa," a major specific substrate for protein kinase C. (1986) (118)
- Localization of cyclic GMP-dependent protein kinase and substrate in mammalian cerebellum. (1980) (118)
- Redistribution of synaptophysin and synapsin I during alpha-latrotoxin- induced release of neurotransmitter at the neuromuscular junction (1990) (118)
- Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse. (1990) (118)
- Adenosine 3',5'-Monophosphate-Dependent Protein Kinase from Brain (1969) (117)
- Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease (2014) (117)
- Role of Calcineurin and Protein Phosphatase‐2A in the Regulation of DARPP‐32 Dephosphorylation in Neostriatal Neurons (1999) (117)
- Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration (1975) (117)
- Molecular evolution of the synapsin gene family. (1999) (117)
- Cannabinoid Action Depends on Phosphorylation of Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa at the Protein Kinase A Site in Striatal Projection Neurons (2005) (116)
- Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate-dependent protein kinase (1984) (115)
- Cyclic nucleotide-dependent protein kinases. 8. An assay method for the measurement of adenosine 3',5'-monophosphate in various tissues and a study of agents influencing its level in adipose cells. (1970) (115)
- Antibodies to synaptophysin interfere with transmitter secretion at neuromuscular synapses (1992) (115)
- Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra. (1993) (114)
- Protein phosphorylation in nerve terminals: comparison of calcium/calmodulin-dependent and calcium/diacylglycerol-dependent systems (1988) (114)
- Effects of colchicine on cyclic AMP levels in human leukocytes. (1977) (114)
- Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain. (1979) (112)
- Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. (1991) (111)
- A multifunctional calmodulin‐dependent protein kinase (1983) (111)
- Adenosine 3',5'-Monophosphate Content in Rat Caudate Nucleus: Demonstration of Dopaminergic and Adrenergic and Receptors (1974) (110)
- Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction (1993) (109)
- Muscarinic cholinergic regulation of cyclic guanosine 3,5-monophosphate in autonomic ganglia: possible role in synaptic transmission. (1975) (109)
- Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade (1998) (108)
- Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease (2001) (108)
- p11 (S100A10)--an inducible adaptor protein that modulates neuronal functions. (2007) (108)
- Roscovitine: a novel regulator of P/Q‐type calcium channels and transmitter release in central neurons (2002) (107)
- Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. (2006) (107)
- A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling (2004) (106)
- Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. (1997) (106)
- WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines (2008) (106)
- The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization. (1987) (106)
- Phosphorylation of DARPP-32 at Threonine-34 is Required for Cocaine Action (2006) (106)
- The B″/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A (2007) (106)
- Synapsin IIa Controls the Reserve Pool of Glutamatergic Synaptic Vesicles (2008) (105)
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine. (1984) (105)
- Cyclic nucleotides, phosphorylated proteins, and the nervous system. (1979) (105)
- Guanosine 3':5'-cyclic monophosphate-dependent phosphorylation of endogenous substrate proteins in membranes of mammalian smooth muscle. (1974) (104)
- Microvesicles of the neurohypophysis are biochemically related to small synaptic vesicles of presynaptic nerve terminals (1989) (103)
- Phosphorylation of VAMP/Synaptobrevin in Synaptic Vesicles by Endogenous Protein Kinases (1995) (102)
- Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. (2006) (102)
- Ontogeny of synaptic phosphoproteins in brain. (1978) (101)
- Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins (2004) (100)
- Protein Phosphatase-1 Regulation in the Induction of Long-Term Potentiation: Heterogeneous Molecular Mechanisms (2000) (99)
- Regulation of Synaptotagmin I Phosphorylation by Multiple Protein Kinases (1999) (99)
- Characterization of synapsin I fragments produced by cysteine-specific cleavage: a study of their interactions with F-actin (1989) (98)
- Identification of Neurodegenerative Factors Using Translatome-Regulatory Network Analysis (2015) (98)
- Stimulation by dopamine of adenosine cyclic 3',5'-monophosphate formation in rat caudate nucleus: effect of lesions of the nigro-neostriatal pathway. (1976) (98)
- Protein Tyrosine Kinase Activity and Its Endogenous Substrates in Rat Brain: A Subcellular and Regional Survey (1988) (98)
- Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C (1987) (97)
- Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. (1995) (97)
- Adenosine 3':5'-monophosphate receptor proteins in mammalian brain. (1978) (96)
- Motivational Effects of Ethanol in DARPP-32 Knock-Out Mice (2001) (96)
- Gleevec inhibits beta-amyloid production but not Notch cleavage. (2003) (96)
- Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. (1999) (95)
- Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. (1994) (95)
- A role for LYNX2 in anxiety-related behavior (2009) (95)
- Histone H3 Phosphorylation is Under the Opposite Tonic Control of Dopamine D2 and Adenosine A2A Receptors in Striatopallidal Neurons (2009) (95)
- Phosphorylation of Protein Phosphatase Inhibitor-1 by Cdk5* (2001) (95)
- Regulation of phosphorylation of a specific protein in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes. (1973) (95)
- Guanosine 3',5'-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission (1974) (94)
- Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells. (1991) (94)
- Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia (2014) (94)
- Dopaminergic regulation of protein phosphorylation in the striatum: DARPP-32 (1987) (94)
- Widespread distribution of protein I in the central and peripheral nervous systems. (1979) (93)
- Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases. (1980) (93)
- The effect of the nerve sheath on the action of local anesthetics. (1965) (93)
- Regulation of protein phosphorylation and membrane permeability by beta-adrenergic agents and cyclic adenosine 3':5'-monophosphate in the avian erythrocyte. (1974) (93)
- DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1. (1986) (92)
- Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity (2006) (92)
- Amyloid‐β oligomers are inefficiently measured by enzyme‐linked immunosorbent assay (2005) (92)
- Differential expression of synapsins I and II among rat retinal synapses (1992) (91)
- Serotonin-sensitive adenylate cyclase in neural tissue and its similarity to the serotonin receptor: a possible site of action of lysergic acid diethylamide. (1974) (91)
- Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP. (1987) (90)
- Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. (1995) (90)
- Aldosterone synthesis by adrenal mitochondria. 3. Participation of cytochrome P-450. (1967) (90)
- Intracellular signals in the brain. (1979) (90)
- Quantitation of nerve terminal populations: Synaptic vesicle‐associated proteins as markers for synaptic density in the rat neostriatum (1988) (90)
- Regulation of receptor function by protein phosphorylation (1987) (90)
- Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments* (2003) (90)
- The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. (2001) (89)
- Synapsin I partially dissociates from synaptic vesicles during exocytosis induced by electrical stimulation (1992) (89)
- Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress (2017) (88)
- Translocation of synapsin I in response to depolarization of isolated nerve terminals. (1989) (88)
- Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells. (1989) (88)
- Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity. (1990) (87)
- Receptor recruitment: a mechanism for interactions between G protein-coupled receptors. (1999) (87)
- The synapsins and the regulation of synaptic function (1990) (85)
- Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex (2001) (85)
- Neurogenic Effects of Fluoxetine Are Attenuated in p11 (S100A10) Knockout Mice (2010) (84)
- Distribution of protein I in mammalian brain as determined by a detergent-based radioimmunoassay. (1981) (84)
- Protein kinase modulator from lobster tail muscle. I. Stimulatory and inhibitory effects of the modulator on the phosphorylation of substrate proteins by guanosine 3',5'-monophosphate-dependent and adenosine 3',5'-monophosphate-dependent protein kinases. (1973) (84)
- A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor (2010) (84)
- Mechanism of Regulation of Casein Kinase I Activity by Group I Metabotropic Glutamate Receptors* (2002) (84)
- PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone. (1997) (83)
- Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway* (1996) (83)
- Na+,K+-ATPase in the Choroid Plexus (1995) (83)
- DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein in tanycytes of the mediobasal hypothalamus: Distribution and relation to dopamine and luteinizing hormone-releasing hormone neurons and other glial elements (1988) (83)
- Immunocytochemical localization of DARPP‐32, a dopamine and cyclic‐ AMP‐regulated phosphoprotein, in the primate brain (1992) (83)
- Characterization of tissue-specific transcription by the human synapsin I gene promoter. (1991) (82)
- Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. (2005) (81)
- Neuronal and behavioural abnormalities in striatal function in DARPP‐32‐mutant mice (1999) (81)
- Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. (1996) (81)
- SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action (2013) (81)
- Dissociation and concomitant activation of adenosine 3',5'-monophosphate-dependent protein kinase by histone. (1971) (81)
- Phosphorylation of DARPP-32, a Dopamine- and cAMP-regulated Phosphoprotein, by Casein Kinase I in Vitro and in Vivo(*) (1995) (80)
- Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. (1999) (80)
- Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures (1993) (80)
- Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes. (2013) (79)
- Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin (2006) (79)
- Immunocytochemical localization of the neuron-specific form of the c- src gene product, pp60c-src(+), in rat brain (1990) (79)
- Calcium‐dependent serine phosphorylation of synaptophysin (1993) (78)
- Phosphorylation of alzheimer amyloid precursor protein by protein kinase C (1992) (78)
- Regulation of Na+, K+ ‐ATPase Isoforms in Rat Neostriatum by Dopamine and Protein Kinase C (1999) (78)
- Protein phosphatase 1 regulation by inhibitors and targeting subunits (2001) (77)
- PNUTS, a Protein Phosphatase 1 (PP1) Nuclear Targeting Subunit (2003) (77)
- Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1 (2002) (77)
- Nerve impulses increase the phosphorylation state of protein I in rabbit superior cervical ganglion (1982) (77)
- DARPP-32, a dopamine-regulated phosphoprotein. (1986) (77)
- Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism* (2012) (77)
- Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons (2004) (77)
- Synapsin I, an actin-binding protein regulating synaptic vesicle traffic in the nerve terminal. (1994) (76)
- Effects of the neuronal phosphoprotein synapsin I on actin polymerization. I. Evidence for a phosphorylation-dependent nucleating effect. (1992) (75)
- Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. (1997) (75)
- Phosphorylation-dependent inhibition by synapsin I of organelle movement in squid axoplasm (1989) (75)
- Ischemic Stroke Injury Is Mediated by Aberrant Cdk5 (2014) (75)
- Pharmacological analysis of synaptically mediated increase in cyclic adenosine monophosphate in rabbit superior cervical ganglion. (1974) (75)
- Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. (1993) (74)
- Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity. (1997) (74)
- Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium. (1996) (74)
- DARPP‐32, a phosphoprotein enriched in dopaminoceptive neurons bearing dopamine D1 receptors: DIstribution in the cerebral cortex of the newborn and adult rhesus monkey (1990) (74)
- Accelerated Structural Maturation Induced by Synapsin I at Developing Neuromuscular Synapses of Xenopus laevis (1995) (73)
- Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E (1996) (73)
- [Ca2+]i determines the effects of protein kinases A and C on activity of rat renal Na+,K+‐ATPase (1999) (73)
- Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. (2015) (73)
- Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis (2018) (73)
- Synapsin I Regulates Glutamate Release from Rat Brain Synaptosomes (1992) (73)
- Serotonin stimulates phosphorylation of Protein I in the facial motor nucleus of rat brain (1981) (72)
- The DARPP-32 knockout mouse (2000) (72)
- Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function (2008) (72)
- Corticosterone increases the amount of protein 1, a neuron-specific phosphoprotein, in rat hippocampus. (1981) (72)
- Ca2+/calmodulin-dependent protein kinase II: identification of autophosphorylation sites responsible for generation of Ca2+/calmodulin-independence. (1987) (71)
- Dopamine and depolarizing agents regulate the state of phosphorylation of protein I in the mammalian superior cervical sympathetic ganglion. (1980) (71)
- Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. (1989) (71)
- ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine- innervated brain regions. II. Immunocytochemical localization in rat brain (1989) (71)
- On the mechanism of action of cyclic AMP and its role in synaptic transmission. (1972) (71)
- Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice (2012) (70)
- Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases (2011) (70)
- Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms (1999) (70)
- Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner* (2009) (70)
- Identification of two protein kinases that phosphorylate the neural cell-adhesion molecule, N-CAM (1989) (69)
- Autophosphorylation and activation of Ca2+/calmodulin-dependent protein kinase II in intact nerve terminals. (1988) (69)
- Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor. (1983) (69)
- Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2019) (69)
- Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail (1993) (69)
- Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain (1997) (69)
- Calcium/calmodulin-dependent protein phosphorylation in the nervous system of Aplysia (1984) (69)
- The role of ventral striatal cAMP signaling in stress-induced behaviors (2015) (69)
- Expression of APP in brains of transgenic mice containing the entire human APP gene. (1993) (68)
- Characterization in Mammalian Brain of a DARPP‐32 Serine Kinase Identical to Casein Kinase II (1990) (68)
- A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. I. Purification and characterization. (1981) (67)
- Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia (2017) (67)
- Ca2+ and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue. (1979) (67)
- Kinetic analysis of the phosphorylation‐dependent interactions of synapsin I with rat brain synaptic vesicles (1997) (67)
- Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: Localization to and within dendritic spines (2004) (67)
- Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3 (2003) (67)
- The Arctic Alzheimer mutation favors intracellular amyloid‐β production by making amyloid precursor protein less available to α‐secretase (2007) (67)
- Protein phosphorylation and neuronal function. (1991) (67)
- Differential expression of ARPP-16 and ARPP-19, two highly related cAMP- regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions (1990) (67)
- Determination of Intermediary Metabolites by Enzymic Fluorimetry (1956) (66)
- Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides. (1995) (66)
- Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists (2003) (66)
- Identification of endogenous substrate proteins for cAMP-dependent protein kinase in bovine brain. (1980) (66)
- Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology (2009) (66)
- Synapsin Is a Novel Rab3 Effector Protein on Small Synaptic Vesicles (2004) (66)
- Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities. (1992) (65)
- Monoamine Oxidases - New Vistas (1972) (65)
- Kinetics of G-protein–coupled receptor endosomal trafficking pathways revealed by single quantum dots (2010) (65)
- Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons (1989) (65)
- Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model (2010) (65)
- DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task (2000) (65)
- Regional distribution of calcium- and cyclic adenosine 3':5'- monophosphate-regulated protein phosphorylation systems in mammalian brain. I. Particulate systems (1983) (63)
- Regulation of protein phosphorylation and sodium transport in toad bladder (1975) (63)
- Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex. (1985) (63)
- Mutation of the Protein Kinase C Phosphorylation Site on Rat α1 Na+,K+-ATPase Alters Regulation of Intracellular Na+ and pH and Influences Cell Shape and Adhesiveness* (1997) (63)
- Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. II. Solubilization, purification, and some properties of an endogenous adenosine 3':5'-monophosphate-dependent protein kinase. (1977) (63)
- AGAP1/AP‐3‐dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release (2010) (63)
- Activation by adenosine 3':5'-monophosphate of a membrane-bound phosphoprotein phosphatase from toad bladder. (1973) (62)
- Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. (1997) (62)
- Discovery of protein phosphatase 2C inhibitors by virtual screening. (2006) (61)
- Spinophilin is phosphorylated by Ca2+/calmodulin‐dependent protein kinase II resulting in regulation of its binding to F‐actin (2004) (61)
- Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2a receptor signaling in the neostriatum (2006) (61)
- Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay. (2005) (60)
- Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system (1985) (60)
- Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue (1994) (60)
- Role of adrenoceptors in the regulation of dopamine/DARPP‐32 signaling in neostriatal neurons (2010) (60)
- Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice (2003) (60)
- A specific substrate from rabbit cerebellum for guanosine-3':5'-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites. (1981) (59)
- Synapsin IIa accelerates functional development of neuromuscular synapses. (1994) (59)
- Distribution and cellular localization of DARPP-32 mRNA in rat brain. (1990) (59)
- Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. (2019) (59)
- Localization of synapsin I at the frog neuromuscular junction (1988) (59)
- Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). (2005) (59)
- Distribution of Protein Phosphatase Inhibitor‐1 in Brain and Peripheral Tissues of Various Species: Comparison with DARPP‐32 (1992) (59)
- Hormonal control of protein phosphorylation in turkey erythrocytes. Phosphorylation by cAMP-dependent and Ca2+-dependent protein kinases of distinct sites in goblin, a high molecular weight protein of the plasma membrane. (1980) (59)
- Membrane depolarization and carbamoylcholine stimulate phosphatidylinositol turnover in intact nerve terminals. (1988) (59)
- Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for regulation of neurotransmitter release. (1991) (59)
- Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy. (1989) (59)
- Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells. (1978) (59)
- Spinophilin/neurabin reciprocally regulate signaling intensity by G protein‐coupled receptors (2007) (59)
- Spinophilin Stabilizes Cell Surface Expression of α2B-Adrenergic Receptors* (2003) (58)
- HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors (2019) (58)
- Widespread occurrence of a specific protein in vertebrate tissues and regulation by cyclic AMP of its endogenous phosphorylation and dephosphorylation. (1975) (57)
- Physiological Role for Casein Kinase 1 in Glutamatergic Synaptic Transmission (2005) (57)
- PCPP-260, a Purkinje cell-specific cyclic AMP-regulated membrane phosphoprotein of Mr 260,000 (1986) (57)
- Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. (1994) (56)
- Autophosphorylation of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. (1974) (56)
- Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1. (2006) (56)
- Expression of synapsin i correlates with maturation of the neuromuscular synapse (1996) (56)
- On the mechanism of action of cyclic AMP. (1970) (55)
- Characterization of Transcripts from the Synapsin III Gene Locus (1999) (55)
- Alzheimer β/A4‐Amyloid Precursor Protein: Evidence for Putative Amyloidogenic Fragment (1992) (55)
- Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex (2012) (55)
- Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19 (2002) (55)
- I kappa B Kinase Regulates Social Defeat Stress- Induced Synaptic and Behavioral Plasticity (2010) (55)
- Cyclic GMP-dependent protein phosphorylation in intact medial tissue and isolated cells from vascular smooth muscle. (1980) (55)
- Alteration by p11 of mGluR5 localization regulates depression-like behaviors (2015) (55)
- Cyclic Nucleotide‐Dependent Protein Kinases and Some Major Substrates in the Rat Cerebellum After Neonatal X‐Irradiation (1983) (54)
- Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain (2002) (54)
- Aldosterone-induced increase in protein phosphatase activity of toad bladder. (1974) (54)
- A major calmodulin-binding protein common to various vertebrate tissues. (1982) (54)
- Bacterial lipopolysaccharide regulates the phosphorylation of the 68K protein kinase C substrate in macrophages. (1989) (54)
- Purification and characterization of protein IIIb, a mammalian brain phosphoprotein. (1982) (54)
- Cocaine Self-Administration in Mice Is Inversely Related to Phosphorylation at Thr34 (Protein Kinase A Site) and Ser130 (Kinase CK1 Site) of DARPP-32 (2006) (53)
- Bidirectional changes in synapsin I phosphorylation at MAP kinase‐dependent sites by acute neuronal excitation in vivo (2002) (53)
- Material for Alterations in 5-HT 1 B Receptor Function by p 11 in Depression-Like States (2005) (53)
- After‐potentials in mam‐malian non‐myelinated nerve fibres (1958) (53)
- Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II. (1991) (53)
- Mating-Related Stimulation Induces Phosphorylation of Dopamine- and Cyclic AMP-Regulated Phosphoprotein-32 in Progestin Receptor-Containing Areas in the Female Rat Brain (1998) (53)
- GABA[A] receptors and anxiety : from neurobiology to treatment (1995) (53)
- On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide. (1966) (53)
- Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer Amyloid Precursor Protein (1995) (53)
- Presence of free cyclic AMP receptor protein and regulation of its level by cyclic AMP in neuroblastoma-glioma hybrid cells. (1979) (53)
- Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. (1990) (53)
- Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology (2008) (53)
- NICOTINAMIDE DEAMIDASE FROM MAMMALIAN LIVER. (1965) (53)
- Protein kinase modulator from lobster tail muscle. II. Effects of the modulator on holoenzyme and catalytic subunit of guanosine 3',5'-monophosphate-dependent and adenosine 3',5'-monophosphate-dependent protein kinases. (1973) (52)
- Serum antibodies that distinguish between the phospho- and dephospho-forms of a phosphoprotein (1982) (52)
- Specificity of the Binding of Synapsin I to Src Homology 3 Domains* (2000) (52)
- Co-localization of the D1 dopamine receptor in a subset of DARPP-32-containing neurons in rat caudate–putamen (1997) (52)
- Protein phosphorylation in cultured endothelial cells (1986) (52)
- Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome–lysosome fusion (2017) (52)
- Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration. (1993) (52)
- Similarities between protein IIIa and protein IIIb, two prominent synaptic vesicle-associated phosphoproteins (1987) (51)
- Elevation of p11 in lateral habenula mediates depression-like behavior (2017) (51)
- The cDNA and derived amino acid sequences for rat and human synaptophysin. (1987) (51)
- Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear (2010) (51)
- Excitatory amino acid antagonists and Parkinson's disease (1990) (51)
- Reduced levels of the tyrosine phosphatase STEP block beta amyloid‐mediated GluA1/GluA2 receptor internalization (2011) (51)
- Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons (2013) (51)
- Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents. (1982) (50)
- Cyclic nucleotides, protein phosphorylation and synaptic function. (1976) (50)
- A 127‐kDa Protein (UV‐DDB) Binds to the Cytoplasmic Domain of the Alzheimer's Amyloid Precursor Protein (1999) (50)
- Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I. (2007) (50)
- Regulation of rat Na+-K+-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA. (1997) (50)
- A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases. (1981) (50)
- Biochemical characterization of histamine-sensitive adenylate cyclase in mammalian brain. (1977) (50)
- Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. (1999) (49)
- Activation of the cAMP/PKA/DARPP-32 Signaling Pathway is Required for Morphine Psychomotor Stimulation but not for Morphine Reward (2007) (49)
- Cyclic nucleotides, protein phosphorylation, and neuronal function. (1975) (49)
- Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease. (1994) (49)
- An assay method for cyclic AMP and cyclic GMP based upon their abilities to activate cyclic AMP-dependent and cyclic GMP-dependent protein kinases. (1972) (49)
- Co-expression of serotonin 5-HT1B and 5-HT4 receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum (2011) (49)
- Comparison of the immunocytochemical localization of DARPP‐32 and I‐1 in the amygdala and hippocampus of the rhesus monkey (1993) (49)
- Forebrain overexpression of CK1δ leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD (2010) (48)
- Estradiol affects spinophilin protein differently in gonadectomized males and females (2004) (48)
- Subcellular localization of cyclic GMP-dependent protein kinase and its substrates in vascular smooth muscle. (1980) (48)
- Cell-specific localization of the alpha-subunit of calcium/calmodulin-dependent protein kinase II in Purkinje cells in rodent cerebellum. (1988) (48)
- Ontogeny of the dopamine and cyclic adenosine-3′: 5′ -monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system (1988) (48)
- DARPP‐32 and Phosphatase Inhibitor‐1, Two Structurally Related Inhibitors of Protein Phosphatase‐1, Are Both Present in Striatonigral Neurons (1988) (48)
- DARPP-32 development in the caudate nucleus is independent of afferent input from the substantia nigra. (1990) (48)
- Generation and regulation of beta-amyloid peptide variants by neurons. (1998) (48)
- Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion (1982) (48)
- Prostaglandin E2 Acts on EP1 Receptor and Amplifies Both Dopamine D1 and D2 Receptor Signaling in the Striatum (2007) (48)
- Effects of the neuronal phosphoprotein synapsin I on actin polymerization. II. Analytical interpretation of kinetic curves. (1992) (47)
- Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus (2017) (47)
- Cellular and subcellular distribution of spinophilin, a PP1 regulatory protein that bundles F‐actin in dendritic spines (2004) (47)
- Synapsin I in PC12 cells. I. Characterization of the phosphoprotein and effect of chronic NGF treatment (1987) (47)
- Spatial and Temporal Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Developing Neurons (2002) (47)
- Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. (1996) (47)
- Impaired conditioned taste aversion learning in spinophilin knockout mice. (2001) (46)
- Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus (2008) (46)
- Immunocytochemical localization of amyloid precursor protein in rat brain (1994) (46)
- Study of autophosphorylation of isoenzymes of cyclic AMP-dependent protein kinases. (1977) (46)
- Immunocytochemical localization of phosphatase inhibitor‐1 in rat brain (1991) (46)
- Cyclic GMP-dependent protein phosphorylation in mammalian brain. (1983) (46)
- Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse (2001) (45)
- Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice (2015) (45)
- Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice (2019) (45)
- Steroid hormones may regulate autophosphorylation of adenosine-3',5'-monophosphate-dependent protein kinase in target tissues. (1981) (45)
- μ‐ and δ‐opioid receptor agonists inhibit DARPP‐32 phosphorylation in distinct populations of striatal projection neurons (1999) (45)
- A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation (2009) (44)
- Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture. (1988) (44)
- Subcellular distribution of neurabin immunolabeling in primate prefrontal cortex: comparison with spinophilin. (2004) (44)
- Pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain. (1979) (44)
- Synapsin Ia, Synapsin Ib, Protein IIIa, and Protein IIIb, Four Related Synaptic Vesicle‐Associated Phosphoproteins, Share Regional and Cellular Localization in Rat Brain (1988) (43)
- Regulation by lipolytic and antillipolytic compounds of the phosphorylation of specific proteins in isolated intact fat cells. (1976) (43)
- Spinophilin regulates Ca 2 + signalling by binding the N-terminal domain of RGS 2 and the third intracellular loop of G-protein-coupled receptors (2005) (43)
- Effect of frequency of electrical stimulation on the concentration of intermediary metabolites in mammalian non‐myelinated fibres (1959) (43)
- Synapsins Contain O‐Linked N‐Acetylglucosamine (1991) (43)
- Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus (2002) (43)
- DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells. (1986) (43)
- Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine (2018) (43)
- Time-resolved fluorescence study of the neuron-specific phosphoprotein synapsin I. Evidence for phosphorylation-dependent conformational changes. (1990) (43)
- A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake (2019) (43)
- Calmodulin-dependent protein kinase and associated substrates in Torpedo electric organ. (1983) (43)
- Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells. (1988) (43)
- Aldosterone synthesis by adrenal mitochondria. (1966) (42)
- Regulation of myocardial cyclic AMP by isoproterenol, glucagon and acetylcholine. (1971) (42)
- Synapsin Is a Novel Rab3 Effector Protein on Small Synaptic Vesicles (2004) (42)
- Protein phosphatase-1 in the kidney: evidence for a role in the regulation of medullary Na(+)-K(+)-ATPase. (1995) (42)
- Nicotinamide deamidase in rat liver and the biosynthesis of NAD (1963) (41)
- Restoration by barium of action potentials in sodium‐deprived mammalian B and C fibres (1959) (41)
- Genetic variations of an oxidase in mammals. (1967) (41)
- Bidirectional regulation of Aβ levels by Presenilin 1 (2017) (41)
- Synapsin I, a neuron-specific phosphoprotein interacting with small synaptic vesicles and F-actin. (1989) (41)
- Dopamine D1 Receptor‐Induced Gene Transcription Is Modulated by DARPP‐32 (2000) (40)
- APP processing, Aβ-amyloidogenesis, and the pathogenesis of Alzheimer's disease (1994) (40)
- "Second messengers" in the brain. (1977) (40)
- Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32‐dependent pathways: evidence from PDE1B‐DARPP32 double‐knockout mice (2006) (40)
- A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons (2010) (40)
- Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling (2008) (40)
- Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11 (2012) (39)
- Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein (1988) (39)
- Hormonally regulated phosphoprotein of turkey erythrocytes: localization to plasma membrane (1979) (39)
- Effects of catecholamines and prostaglandin E1 on cyclic AMP, cation fluxes, and protein phosphorylation in the frog erythrocyte. (1980) (39)
- Hormonal control of Na+-K+ co-transport in turkey erythrocytes. Multiple site phosphorylation of goblin, a high molecular weight protein of the plasma membrane. (1980) (39)
- Phosphorylation‐dependent Effects of Synapsin IIa on Actin Polymerization and Network Formation (1997) (39)
- The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines (2007) (39)
- Differential Localization of Protein Phosphatase-1α, β and γ1 Isoforms in Primate Prefrontal Cortex (2005) (39)
- Enthalpy of hydrolysis of the 3' bond of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate. (1969) (39)
- Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia. (1978) (38)
- Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart. (1993) (38)
- Introduction of Impermeant Molecules into Synaptosomes Using Freeze/Thaw Permeabilization (1989) (38)
- Cellular and subcellular localization of protein I in the peripheral nervous system. (1982) (37)
- Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons (2005) (37)
- Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum. (1993) (37)
- GSAP modulates γ-secretase specificity by inducing conformational change in PS1 (2018) (37)
- Presenilins and γ-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the γ-Secretase Complex Components* (2004) (37)
- A mathematical tool for exploring the dynamics of biological networks (2007) (37)
- Increase in synapsin I phosphorylation implicates a presynaptic component in septal kindling (1995) (37)
- Synapsin I in PC12 cells. II. Evidence for regulation by NGF of phosphorylation at a novel site (1987) (36)
- Increased cyclic GMP levels associated with contraction in muscle fibres of the giant barnacle (1977) (36)
- Remodeling of cytoskeletal architecture of nonneuronal cells induced by synapsin. (1994) (35)
- Neurabin Scaffolding of Adenosine Receptor and RGS4 Regulates Anti-Seizure Effect of Endogenous Adenosine (2012) (35)
- Requirement for DARPP‐32 in mediating effect of dopamine D2 receptor activation (1999) (35)
- Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum (2016) (35)
- Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents. (1979) (35)
- Active catalytic fragment of Ca2+/calmodulin-dependent protein kinase II. Purification, characterization, and structural analysis. (1991) (35)
- Cell‐ and region‐specific expression of depression‐related protein p11 (S100a10) in the brain (2016) (35)
- Cyclic AMP-dependent and cyclic GMP-dependent protein kinases of nervous tissue. (1981) (35)
- Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons. (1998) (34)
- Adenosine 3',5'-monophosphate content in rat caudate nucleus: demonstration of dopaminergic and adrenergic receptors. (1974) (34)
- Solubilization of a phosphoprotein and its associated cyclic AMP-dependent protein kinase and phosphoprotein phosphatase from synaptic membrane fractions, and some kinetic evidence for their existence as a complex. (1975) (34)
- Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc 2 kinase (1997) (34)
- On the equilibrium of the adenylate cyclase reaction. (1971) (34)
- Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia (2000) (34)
- Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor (2003) (34)
- CK2 negatively regulates Gαs signaling (2009) (34)
- Phosphorylation of DARPP‐32 Is Regulated by GABA in Rat Striatum and Substantia Nigra (1994) (34)
- Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus (1981) (33)
- Neuron-specific phosphoproteins as models for neuronal gene expression. (1983) (33)
- The interaction of colchicine with hormone-sensitive adenylate cyclase in human leukocytes. (1979) (33)
- ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. (2001) (33)
- Effects of cholera enterotoxin on catecholamine-stimulated changes in cation fluxes, cell volume, and cyclic AMP levels in the turkey erythrocyte. (1977) (33)
- Emergence of cyclic guanosine 3':5'-monophosphate-dependent protein kinase immunoreactivity in developing rhesus monkey cerebellum: correlative immunocytochemical and electron microscopic analysis (1984) (33)
- Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia (2005) (33)
- The convergence of endosomal and autophagosomal pathways (2014) (33)
- Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis. (1994) (32)
- Regulation of synthesis of guanosine 3':5'-cyclic monophosphate in neuroblastoma cells. (1978) (32)
- Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Protein a (1993) (32)
- Nicotinic cholinergic stimulation increases cyclic GMP levels in vertebrate skeletal muscle (1978) (32)
- ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine- innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleus (1989) (32)
- Enhanced generation of Alzheimer’s amyloid‐β following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C (2009) (32)
- DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons (2015) (32)
- Stimulation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases by some analogs of adenosine 3',5'-monophosphate. (1970) (32)
- α2-Adrenergic Agonist Enrichment of Spinophilin at the Cell Surface Involves βγ Subunits of Gi Proteins and Is Preferentially Induced by the α2A-Subtype (2005) (32)
- Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior (2019) (32)
- Identification of the cyclic AMP-dependent protein kinase responsible for endogenous phosphorylation of substrate proteins in synaptic membrane fraction from rat brain. (1979) (31)
- Yield of oxidative phosphorylation associated with the oxidation of succinate to fumarate. (1959) (31)
- Dual involvement of G-substrate in motor learning revealed by gene deletion (2009) (31)
- Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry. (2005) (31)
- C99 selectively accumulates in vulnerable neurons in Alzheimer's disease (2020) (31)
- PITUITARY INFLUENCE OF PYRIDINE NUCLEOTIDE METABOLISM OF RAT LIVER. (1964) (31)
- Serine phosphorylation of the secreted extracellular domain of APP. (1993) (30)
- Effects of Chronic ‘Binge’ Cocaine Administration on Plasma ACTH and Corticosterone Levels in Mice Deficient in DARPP-32 (1999) (30)
- Preliminary evidence that early reduction in p11 levels in Natural Killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram (2014) (30)
- Selective Knockout of the Casein Kinase 2 in D1 Medium Spiny Neurons Controls Dopaminergic Function (2013) (30)
- THE DETERMINATION AND PHYSIOLOGICAL DISTRIBUTION OF DIPYRIDAMOLE AND ITS GLUCURONIDES IN BIOLOGICAL MATERIAL. (1963) (30)
- APP intracellular domain/WAVE1 pathway reduces amyloid β production (2015) (30)
- Some relationships between action potential, oxygen consumption and coenzyme content in degenerating peripheral axons. (1954) (30)
- ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase) (2017) (29)
- Synapsin I, a phosphoprotein associated with synaptic vesicles: possible role in regulation of neurotransmitter release. (1987) (29)
- Developmental regulation of phosphoprotein gene expression in the caudate-putamen of rat: An in situ hybridization study (1992) (29)
- Metabolic studies on the hyperpolarization following activity in mammalian non‐myelinated nerve fibres (1962) (29)
- Cholinergic regulation of protein III phosphorylation in bovine adrenal chromaffin cells (1988) (29)
- Synapsin I is a highly surface-active molecule. (1991) (29)
- Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action (2019) (29)
- Cell-Type Specific Expression of p11 Controls Cocaine Reward (2014) (29)
- Localization of DARPP-32 immunoreactive neurons in the bed nucleus of the stria terminalis and central nucleus of the amygdala: co-distribution with axons containing tyrosine hydroxylase, vasoactive intestinal polypeptide, and calcitonin gene-related peptide (2004) (29)
- Neuronal localization of specific brain phosphoproteins (1978) (29)
- Chemistry of dopamine receptors. (1975) (29)
- D-l and D-2 dopaminergic receptors regulate protein phosphorylation in the rat neurohypophysis (1985) (29)
- Phosphorylation of a single mast cell protein in response to drugs that inhibit secretion. (1981) (28)
- Serine and Threonine Phosphorylation (1999) (28)
- Postsynaptic Element Contributes to the Delay in Synaptogenesis in Synapsin I-Deficient Neurons (1996) (28)
- Anti-synapsin monoclonal antibodies: epitope mapping and inhibitory effects on phosphorylation and Grb2 binding. (1997) (28)
- Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. (2003) (28)
- After-potentials in mammalian non-myelinated nerve fibres. (1958) (28)
- Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons (1994) (28)
- Regulation of DARPP-32 phosphorylation by Δ9-tetrahydrocannabinol (2008) (28)
- ARPP-21, A cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: Tissue distribution and regulation of phosphorylation in rat brain (1990) (28)
- Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles. (1990) (27)
- Morphometrical evidence for a complex organization of tyrosine hydroxylase-,enkephalin- and darpp-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum (1988) (27)
- DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus. (1988) (27)
- Chronic Treatment of Rats with SCH‐23390 or Raclopride Does Not Affect the Concentrations of DARPP‐32 or Its mRNA in Dopamine‐Innervated Brain Regions (1990) (27)
- Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex. (2005) (27)
- The renal dopamine system. (1998) (27)
- An analysis of synapsin II, a neuronal phosphoprotein, in postmortem brain tissue from alcoholic and neuropsychiatrically ill adults and medically ill children and young adults. (1990) (26)
- Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment (2019) (26)
- The enthalpy of hydrolysis of various 3',5'-and 2',3'-cyclic nucleotides. (1971) (26)
- Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease (2017) (26)
- THE ISOLATION OF SYNAPTOSOMES FROM THE BRAIN OF A TELEOST FISH, CENTRIOPRISTES STRIATUS (1971) (25)
- Identification of synapsin I peptides that insert into lipid membranes. (2001) (25)
- Distribution of protein phosphatases‐1α and ‐1γ1 and the D1 dopamine receptor in primate prefrontal cortex: Evidence for discrete populations of spines (2001) (25)
- Recruitment of renal dopamine 1 receptors requires an intact microtubulin network (2003) (25)
- Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements (2017) (25)
- ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. (1989) (25)
- Adenosine 3':5'-cyclic monophosphate as a mediator in the action of neurohumoral agents. (1972) (24)
- Synapsin I: a review of its distribution and biological regulation. (1986) (24)
- Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 ‘Knockout’ (2003) (24)
- Protein phosphorylation and the regulation of cation cotransport. (1980) (24)
- Regulator of calmodulin signaling knockout mice display anxiety‐like behavior and motivational deficits (2012) (24)
- A 38 , 000-dalton membrane protein ( p 38 ) present in synaptic vesicles ( synapsin I / subcellular fractionation / integral membrane protein ) (24)
- Improving the quality of immunoblots by chromatography of polyclonal antisera on keratin affinity columns. (1989) (24)
- Phylogenetic Survey of Proteins Related to Synapsin I and Biochemical Analysis of Four Such Proteins from Fish Brain (1985) (24)
- Photoaffinity labeling of the regulatory subunit of cAMP-dependent protein kinase. (1983) (24)
- Na+,K+-ATPase Phosphorylation in the Choroid Plexus: Synergistic Regulation by Serotonin/Protein Kinase C and Isoproterenol/cAMP-PK/PP-1 Pathways (1998) (24)
- Stimulation of b-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal b-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling (2001) (23)
- Autoregulation of phosphorylation of the nicotinic acetylcholine receptor (1994) (23)
- Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization (2010) (23)
- Relevance of the COPI complex for Alzheimer’s disease progression in vivo (2016) (23)
- Adenosine 3': 5' monophosphate dependent protein phosphatase activity in synaptic membrane fractions (1975) (23)
- Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland. (1990) (23)
- Protein Kinase C-Dependent Dephosphorylation of Tyrosine Hydroxylase Requires the B56δ Heterotrimeric Form of Protein Phosphatase 2A (2011) (23)
- Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs. (1988) (23)
- On the metabolic basis of nervous activity (1969) (23)
- Synapsin IIa Bundles Actin Filaments (1994) (23)
- ARPP‐16/ARPP‐19: a highly conserved family of cAMP‐regulated phosphoproteins (2001) (23)
- Activation of the cAMP/PKA/DARPP-32 Signaling Pathway is Required for Morphine Psychomotor Stimulation but not for Morphine Reward (2007) (22)
- The active structure of local anesthetics. (1965) (22)
- Nitric oxide regulates synaptic transmission between spiny projection neurons (2014) (22)
- Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage (2017) (22)
- Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition (2017) (22)
- Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function (2015) (22)
- Protein kinases in developing rat brain. (1978) (22)
- Regulation of APP Processing by Intra‐ and Intercellular Signals a (1996) (22)
- Cyclic nucleotide-dependent protein kinases. VII. Comparison of various histones as substrates for adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases. (1970) (22)
- Identification of synapsin I peptides that insert into lipid membranes (2001) (22)
- Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression (2019) (22)
- Synaptophysin and synapsin I as tools for the study of the exo-endocytotic cycle. (1989) (22)
- Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain. (1988) (22)
- A solid-phase assay for the phosphorylation of proteins blotted on nitrocellulose membrane filters. (1986) (22)
- Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution* (2016) (22)
- The cyclic nucleotide-dependent phosphorylation of aortic smooth muscle membrane proteins. (1987) (22)
- Neuronal phosphoproteins (2008) (21)
- Neuronal Localization of Ca2+‐dependent Protein Phosphorylation in Brain (1980) (21)
- A Noncanonical Postsynaptic Transport Route for a GPCR Belonging to the Serotonin Receptor Family (2012) (21)
- Chapter 13 DARPP-32, a dopamine-regulated phosphoprotein (1986) (21)
- Dopamine D1 Agonist SKF 38393 Increases the State of Phosphorylation of ARPP‐21 in Substantia Nigra (1993) (21)
- Adenosine 3',5'-monophosphate-dependent protein kinase from brain. (1968) (21)
- SPECIFIC INHIBITION BY “LOOP” DIURETICS OF AN ANION‐DEPENDENT NA++K+ COTRANSPORT SYSTEM IN AVIAN ERYTHROCYTES * (1980) (21)
- Photoaffinity labeling of a guanosine 3':5'-monophosphate-dependent protein kinase from vascular smooth muscle. (1978) (20)
- δ-COP modulates Aβ peptide formation via retrograde trafficking of APP (2016) (20)
- Protein Phosphotyrosine in Mouse Brain: Developmental Changes and Regulation by Epidermal Growth Factor, Type I Insulin‐Like Growth Factor, and Insulin (1992) (20)
- DARPP-32 Involvement in the Photic Pathway of the Circadian System (2006) (20)
- AP-1 controls the p11-dependent antidepressant response (2020) (20)
- Release of inhibition of rat liver nicotinamide deamidase by hypophysectomy (1963) (20)
- Serotonin receptor 4 in the hippocampus modulates mood and anxiety (2021) (20)
- Localization of cyclic GMP-dependent protein kinase in rat basal ganglia neurons. (1989) (20)
- CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior (2018) (20)
- M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia (2016) (19)
- Identification of a dopamine- and 3′ 5′-cyclic adenosine monophosphate- regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland (1991) (19)
- Use of phosphosynapsin I-specific antibodies for image analysis of signal transduction in single nerve terminals. (2000) (19)
- Inhibitor-1 Is Not Required for the Activation of Glycogen Synthase by Insulin in Skeletal Muscle* (1999) (19)
- Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical. (1989) (19)
- Preparation and characterization of recombinant protein phosphatase 1. (2003) (19)
- Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. (2016) (19)
- INCREASED BLOOD PRESSURE AND LOSS OF ANP-INDUCED NATRIURESIS IN MICE LACKING DARPP-32 GENE (2001) (18)
- Coupling calcium to SNARE–mediated synaptic vesicle fusion (1999) (18)
- Physiology and pharmacology of cyclic AMP (1972) (18)
- The dentate gyrus in depression (2019) (18)
- Synapsins as major neuronal Ca2+/S100A1-interacting proteins. (1999) (18)
- Some chemical aspects of neurotransmitter action (1979) (18)
- Protein kinases and phosphoproteins in the nervous system. (1986) (18)
- Dopamine-regulated phosphorylation of synaptic vesicle-associated proteins in rat neostriatum and substantia nigra (1989) (18)
- Norbin: A promising central nervous system regulator. (2010) (18)
- Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons (2019) (17)
- Fetal Death from Nicotinamide-Deficient Diet and Its Prevention by Chlorpromazine and Imipramine (1964) (17)
- Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinol. (2008) (17)
- Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice (2016) (17)
- Correlated light and electron microscopic study of dopaminergic neurons and their synaptic junctions with DARPP‐32‐containing cells in three‐dimensional reaggregate tissue culture (1989) (17)
- Nucleotide sequence of a cDNA for the bovine myristoylated alanine-rich C kinase substrate (MARCKS). (1989) (16)
- The pathway for the biosynthesis of N 1-methyl-4-pyridone-3-carboxamide. (1966) (16)
- Ca 2 + / calmodulin-dependent protein kinase II : Identification of autophosphorylation sites responsible for generation of Ca 2 + / calmodulin-independence ( protein phosphorylation / phosphoproteins / phosphopeptide mapping ) (16)
- Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. (1995) (16)
- A diurnal rhythm in pineal protein 1 content mediated by beta-adrenergic neurotransmission. (1982) (16)
- Effect of hypophysectomy on pyridine nucleotide metabolism. The role of nicotinamide. (1967) (16)
- Dopamine-sensitive adenylate cyclase within laminae of the olfactory tubercle (1977) (16)
- Somatostatin-induced phosphorylation of mast cell proteins. (1981) (16)
- Pharmacological properties of histamine-sensitive adenylate cyclase from guinea pig cardiac ventricular muscle. (1979) (16)
- Protein Phosphorylation is of Fundamental Importance in Biological Regulation (1999) (16)
- A Novel Synaptic Vesicle‐Associated Phosphoprotein: SVAPP‐120 (1991) (15)
- Maintenance of pregnancy in protein-deficient rats by adrenocortical steroid or ACTH administration. (1967) (15)
- Dopamine-sensitive adenylate cyclase and protein phosphorylation in the rat caudate nucleus. (1975) (15)
- Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6. (1999) (15)
- Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopy. (1993) (15)
- Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. (1999) (15)
- Small‐molecule inducers of Aβ‐42 peptide production share a common mechanism of action (2012) (15)
- Ependymal cells-CSF flow regulates stress-induced depression (2021) (15)
- Glutamate regulates adenylate cyclase and guanylate cyclase activities in an isolated membrane preparation from insect muscle (1982) (15)
- p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli (2018) (15)
- Enzyme systems involved in phosphorylation and dephosphorylation of two endogenous phosphoproteins in neuronal membranes. (1977) (15)
- Spatial relationship of the striatonigral and mesostriatal pathways: double-label immunocytochemistry for DARPP-32 and tyrosine hydroxylase (1989) (15)
- Rapid binding of synapsin I to F‐ and G‐actin (1993) (15)
- Coupling calcium to SNARE–mediated synaptic vesicle fusion (1999) (14)
- Determination of relative levels of cyclic AMP in tissues or cells prelabeled with radioactive adenine. (1972) (14)
- Presence of calcium/calmodulin‐dependent protein Kinase II in Nerve terminals of rat brain (1989) (14)
- Prevention and remission by adrenocortical steriods of nicotinamide deficiency disease. II. A study of the mechanism. (1968) (14)
- Biochemical and Immunocytochemical Characterization of p38, an Integral Membrane Glycoprotein of Small Synaptic Vesicles (1987) (14)
- Presence of Protein I, a Phosphoprotein Associated with Synaptic Vesicles, in Cerebellar Granule Cells (1981) (14)
- Hormonal effects on DPN concentration in rat liver. (1961) (14)
- Distribution of protein phosphatases-1 alpha and -1 gamma 1 and the D(1) dopamine receptor in primate prefrontal cortex: Evidence for discrete populations of spines. (2001) (14)
- Synapsin IIa: expression in insect cells, purification, and characterization. (1992) (14)
- ON THE REACTIVITY AND MECHANISM OF ACTION OF CYCLIC NUCLEOTIDES (1971) (13)
- Muscarinic Stimulation and cGMP Synthesis in the Nervous System (1978) (13)
- The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease (2020) (13)
- Metabolism and Function in Nerve Fibers (1971) (13)
- Cholinergic Neurons of the Medial Septum Are Crucial for Sensorimotor Gating (2019) (13)
- 261. DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission (1998) (13)
- Neurotensin regulates DARPP‐32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1‐type receptors (2002) (13)
- Ethologically Based Resolution of D2-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background (2004) (13)
- IDENTIFICATION OF HORMONES AFFECTING PYRIDINE NUCLEOTIDE METABOLISM OF RAT LIVER. (1965) (13)
- Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia (2020) (13)
- Chapter 11 – Calcium-Dependent Protein Phosphorylation in Mammalian Brain and Other Tissues (1980) (13)
- Epigenetic mechanisms of mental retardation. (2011) (13)
- DOPAMINE-, OCTOPAMINE-, AND SEROTONIN-SENSITIVE ADENYLATE CYCLASES: POSSIBLE RECEPTORS IN AMINERGIC NEUROTRANSMISSION (1973) (13)
- The effect of formulation on phenmetrazine plasma levels in man studied by a sensitive analytic method (1967) (13)
- APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease. (1994) (13)
- Aldosterone synthesis by adrenal mitochondria. II. The effect of citric acid cycle intermediates; identification of the soluble stimulatory factor as fumarase. (1967) (12)
- Quantitative labeling of the regulatory subunit of type II cAMP-dependent protein kinase from bovine heart by a photoaffinity analog. (1978) (12)
- Calcium/Calmodulin-Dependent Protein Phosphorylation in the Nervous System (1985) (12)
- Tryptophan pyrrolase activity during pregnancy. (1968) (12)
- Subcellular distribution of the Rho‐GEF Lfc in primate prefrontal cortex: Effect of neuronal activation (2008) (12)
- Studies of the physiological role of specific neuronal phosphoproteins. (1988) (12)
- WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine (2017) (12)
- Studies on the mechanism of action of cyclic AMP in nervous and other tissues. (1970) (12)
- Is myosin phosphatase regulated in vivo by inhibitor‐1? Evidence from inhibitor‐1 knockout mice (2001) (12)
- ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine- innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus (1989) (12)
- ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine- innervated brain regions. II. Molecular cloning and nucleotide sequence (1989) (12)
- Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein (1992) (12)
- Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons (2016) (11)
- p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism (2016) (11)
- The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer βA4-amyloid precursor protein: Some technical notes (1992) (11)
- Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex (2010) (11)
- Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP‐32‐dependent and independent pathways (2005) (11)
- The Amyloid Precursor Protein and Its Regulatory Protein , FE 65 , in Growth Cones and Synapses In Vitro and In Vivo (2003) (11)
- METABOLIC EFFECTS OF TRANQUILIZERS AND HYPOPHYSECTOMY (1962) (11)
- Metabolic Turnover in the Nervous System (1971) (11)
- Laminin and Neuropeptide Y Are Increased by Synapsin Transfection in Cultured NG108‐15 Neuroblastoma/Glioma Hybrid Cells (1995) (11)
- DARPP-32: A Dopamine-regulated Phosphoprotein in the Basal Ganglia (1986) (11)
- Purification and characterization of PCPP‐260: A Purkinje cell‐enriched cyclic amp‐regulated membrane phosphoprotein of Mr 260,000 (1988) (11)
- A Novel Cyclin Provides a Link between Dopamine and RNA Processing (2001) (11)
- Protein III, a neuron-specific phosphoprotein: variant forms found in human brain. (1984) (11)
- Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype. (2005) (10)
- Nicotinamide deamidase in Ehrlich ascites tumor cells. (1966) (10)
- Synapsins as major neuronal Ca 2 + / S 100 A 1-interacting proteins (1999) (10)
- Characterization of Rat ARPP‐21 mRNA: Sequence Analysis, Tissue Distribution, and Regulation (1991) (10)
- Localization of ARPP-90, a major 90 kiloDalton basal ganglion-enriched substrate for cyclic AMP-dependent protein kinase, in striatonigral neurons in the rat brain. (1989) (10)
- Backbone 1H, 15N, and 13C resonance assignments of inhibitor-2 -- a protein inhibitor of protein phosphatase-1. (2000) (10)
- Neuron-specific phosphoproteins in mammalian brain. (1984) (10)
- Identification of hormonally controlled endogenous inhibitor of livernicotinamide deamidase. (1969) (10)
- GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease (2021) (10)
- Demonstration of DARPP-32 in pituicytes of the neurohypophysis-decreased expression after administration of hyperosmotic stimuli. (1989) (10)
- Prevention and remission by adrenocortical steroids of nicotinamide deficiency disorders and of 6-aminonicotinamide toxicity in rats and dogs. (1966) (9)
- Cloning of cDNAs encoding human synapsins IIa and IIb. (1999) (9)
- Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. (1991) (9)
- Positively active: how local anesthetics work. (2010) (9)
- [47] Purification and characterization of cyclic GMP-dependent protein kinases (1974) (9)
- Letter to the Editor: Backbone 1H, 15N, and 13C resonance assignments of inhibitor-2 – a protein inhibitor of protein phosphatase-1 (2000) (9)
- Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol–Mediated Induction of ΔFosB in the Mouse Forebrain (2015) (9)
- Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects (2022) (8)
- New assay methods for cyclic nucleotides (1972) (8)
- Phosphoprotein Phosphatases from Rat Cerebral Cortex I~ISTRIBIJTION ANI> CHARACTERIZATION* (8)
- DARPP-32/Protein Phosphatase-1/Na+/K+ ATPase System: A Mechanism for Bidirectional Control of Cell Function (1994) (8)
- Apolipoprotein E, Aβ‐Amyloid, and the Molecular Pathology of Alzheimer's Disease Therapeutic Implications a (1996) (8)
- Localization of dopamine-sensitive adenylate cyclase activity within laminae of the rat prefrontal cortex (1979) (8)
- Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development (2020) (8)
- Rat DARPP-32: Cloning, sequencing, and characterization of the cDNA (2008) (8)
- Expression of cell-type-specific neuronal phosphoproteins. (1983) (7)
- Dopamine- and adenosine-3′:5′-monophosphate (cAMP)-regulated phosphoprotein of M r 32,000 (DARPP-32) in the retina of cat, monkey and human (1991) (7)
- Synapsin I interacts with cSrc and stimulates its tyrosine kinase activity ( synaptic vesicles y SH 3 domains y synapses ) (1997) (7)
- Bidirectional regulation of Na + , K +-ATPase activity by dopamine and an a-adrenergic agonist ( a-adrenergic receptors / natriuresis / proximal tubules / phosphatase inhibitors ) (7)
- Ovarian function and morphology after deletion of the DARPP-32 gene in mice. (2004) (7)
- Autophosphorylation reversibly regulates the Ca 2 + / calmnodulin-dependence of Ca 2 + / calmodulin-dependent protein kinase II ( phosphorylation / dephosphorylation / thermal stability ) (7)
- Calcium/Diacylglycerol‐Dependent Protein Kinase and Its Major 87‐Kilodalton Protein Substrate Are Differentially Distributed in Rat Basal Ganglia (1989) (7)
- Neurochemistry and neuropharmacology. (1988) (7)
- Identification of Neurensin-2 as a novel modulator of emotional behavior (2021) (7)
- Distinguishing among protein kinases by substrate specificities. (1987) (6)
- Photoaffinity Labeling of Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases (1982) (6)
- Effect of hypophysectomy on liver diphosphopyridine nucleotide: the role of nicotinamide. (1961) (6)
- Reactive Dopamine Leads to Triple Trouble in Nigral Neurons. (2017) (6)
- Response to Comment on "Diverse Psychotomimetics Act Through a Common Signaling Pathway" (2004) (6)
- EFFECT OF STEROID HORMONES ON THE LEVEL OF PROTEIN I IN RAT BRAIN (1981) (6)
- Control of protein phosphatase I in the dendrite. (1999) (6)
- Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. (1992) (6)
- Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice (2016) (6)
- Antidepressant effects of SSRIs are attenuated by anti-inflammatory drugs in mice and humans (2011) (5)
- CK1δ over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes (2018) (5)
- Amyloid β Peptide Formation in Cell-free Preparations (1996) (5)
- Regulation of Striatal Signaling by Protein Phosphatases (2017) (5)
- 9 Phosphorylation of Brain Proteins (1987) (5)
- Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage. (2020) (5)
- Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants (2021) (5)
- Effects of Electromagnetic Radiation on Calcium in the Brain. (1982) (5)
- BIOCHEMICAL CHARACTERIZATION OF THE DOPAMINE RECEPTOR IN THE MAMMALIAN CAUDATE NUCLEUS (1974) (5)
- Letter to the Editor: 1H, 15N, and 13C resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr. 32,000) – a protein inhibitor of protein phosphatase-1 (2004) (5)
- Receptor-Receptor Interactions Mediated by Protein Phosphorylation (1987) (5)
- PROTEIN PHOSPHORYLATION AND SYNAPTIC TRANSMISSION (1981) (5)
- A master regulator in the Brain (2006) (5)
- Differential Localization of Protein Phosphatase-1 a , b and g 1 Isoforms in Primate Prefrontal Cortex (2005) (5)
- Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications. (1996) (5)
- Letter to the Editor: Backbone 1H, 15N, and 13C resonance assignments of ARPP-19 (2001) (5)
- Synapsins as mediators of BDNF-regulated neurotransmitter release (1999) (5)
- Dopamine-regulated protein phosphorylation in the basal ganglia. (1988) (5)
- Modulation of gap junctional conductance in hepatocyte by cyclic amp is protein phosphorylation involved (1985) (4)
- in the forebrain (2016) (4)
- Experience-dependent translational state defined by cell type-specific ribosome profiling (2017) (4)
- Cyclic Nucleotide and Protein Phosphorylation Mechanisms in the Central Nervous System (1979) (4)
- Neuronal protein phosphorylation: Recent studies concerning protein I, A synapse-specific phosphoprotein (1980) (4)
- Binding of Synapsin I to Synaptic Vesicles: Clues from the Study of its Interactions with Liposomes (1993) (4)
- Two sites of action for synapsin domain E in regulating neurotransmitter release (1998) (4)
- Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons (2018) (4)
- Corrigendum to “cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5” [Neuroscience 116 (1) 19–22]* (2003) (4)
- Decrease in phorbol ester‐induced potentiation of noradrenaline release in synapsin I‐deficient mice (2000) (4)
- Turkey must end violent response to protests. (2013) (4)
- Phosphorylation of VAMP/synaptobrevin in synaptic vesicles (1995) (4)
- An analysis of postmortem brain samples from 32 alcoholic and nonalcoholic individuals for protein III, a neuronal phosphoprotein. (1989) (3)
- Protein Phosphorylation: An Overview (1982) (3)
- Norbin (2010) (3)
- CYCLIC NUCLEOTIDES, PROTEIN PHOSPHORYLATION AND THE REGULATION OF FUNCTION IN NERVOUS TISSUE (1973) (3)
- Calmodulin-dependent protein kinase from avian erythrocytes. (1984) (3)
- Protein Dephosphorylation as a Mediator of NMDA Receptor Signal Transduction (1991) (3)
- Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum (2020) (3)
- Nobel laureates' letter to President Bush. (2001) (3)
- A conversation with Paul Greengard. Interview by Eric J Nestler. (2013) (3)
- S.04.02 Biochemical modulation of AMPA receptor function by antidepressants (2003) (3)
- p11 regulates the surface localization of mGluR5 (2015) (3)
- Elevated amyloid β-peptides in brain: Correlation with cognitive decline (2000) (3)
- Building Bridges through Science (2017) (3)
- ARPP-39, a membrane-associated substrate for cyclic AMP-dependent protein kinase present in neostriatal neurons (2007) (3)
- 1H, 15N, and 13C resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr. 32,000)--a protein inhibitor of protein phosphatase-1. (2004) (3)
- Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (55er3)) (2010) (3)
- Molecular definition of CNS cell types and their physiologic responses in health and disease. (2007) (2)
- C99, not beta-amyloid, is associated with selective death of vulnerable neurons in Alzheimer's disease. (2019) (2)
- S.04.01 Diverse psychotomimetics act through a common signaling pathway (2004) (2)
- A pentacyclic triterpene from Ligustrum lucidum targets γ-secretase. (2020) (2)
- Principles of Signal Transduction (2011) (2)
- IRE 1 α induces thioredoxin-interacting protein to activate the NLRP 3 inflammasome and promote programmed cell death during endoplasmic reticulum stress (2014) (2)
- EXPRESSION OF mRNAs ENCODING THE PHOSPHOPROTEINS ARPP‐16/19, ARPP‐21 AND DARPP‐32 IN THE HUMAN BRAIN (1992) (2)
- Aminergic receptors in neural tissue: Dopamine-, octopamine- and serotonin-sensitive adenylate cyclases (1973) (2)
- Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2020) (2)
- Correction: Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice (2019) (2)
- Protein phosphorylation systems in postmortem human brain (2008) (2)
- Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism. (1966) (2)
- IRE1 α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress (2014) (2)
- LIGAND SELECTION FOR PET STUDIES OF D1 DOPAMINE RECEPTORS. RELATIONSHIP BETWEEN DISTRIBUTION OF BINDING SITES AND mRNA FOR DAARPP32 IN THE HUMAN BRAIN (1992) (2)
- C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease (2019) (2)
- Dopamine receptor response to NMDA stimulation. (2006) (2)
- Effect of electrical stimulation on the concentration of phosphorylated intermediary metabolites in mammalian non-myelinated fibres. (1958) (2)
- Ca 2 + and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue ( protein kinase / protein phosphorylation / synaptic membranes / synaptosomes ) (2)
- 801 – CYCLIC NUCLEOTIDES, PHOSPHORYLATED PROTEINS AND DRUG ACTIONS IN THE CENTRAL NERVOUS SYSTEM (1978) (2)
- GSAP Regulates Amyloid Beta Production through Modulation of Amyloid Precursor Protein Trafficking (2020) (2)
- A mathematical tool for exploring the dynamics of biological networks (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 49, (19169-19174) DOI: 10.1073/pnas.0709955104) (2008) (2)
- The role ofDARPP-32 in the actions ofdrugs ofabuse (2004) (2)
- Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex (2011) (2)
- Localization of g-substrate, a specific substrate for cyclic gmp-dependent protein kinase, in purkinje cells of mammalian cerebellum. Abstr. (1982) (1)
- Intraneuronal β-amyloid with aging and alzheimer's disease (2000) (1)
- Erratum for Ouimet et al., ARPP-21, a Cyclic AMP-Regulated Phosphoprotein Enriched in Dopamine-Innervated Brain Regions. II. Immunocytochemical Localization in Rat Brain (1989) (1)
- Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation (2022) (1)
- Neuropeptide Y Inhibits Phosphorylation of 87‐kDa Protein in Rat Vas Deferens a (1990) (1)
- Regulation of MAP kinase activity and phosphorylation of synapsin I in nerve terminals (1997) (1)
- Hormonal control of cerebral amyloidogenesis in Alzheimer's diseases (2008) (1)
- 801 – CYCLIC NUCLEOTIDES, PHOSPHORYLATED PROTEINS AND DRUG ACTIONS IN THE CENTRAL NERVOUS SYSTEM (1978) (1)
- Regulation of APP Metabolism by Protein Phosphorylation (1998) (1)
- A promising central nervous system regulator (2010) (1)
- Axon Regeneration Requires a Conserved MAP Kinase Pathway (2009) (1)
- General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration (1990) (1)
- P.1.05 Involvement of DARPP-32, FosB, and dynorphin in voluntary wheel running (2008) (1)
- Hormonal regulation of Na+,K+-ATPase activity (1994) (1)
- Correction: Cellular and molecular basis for stress-induced depression (2019) (1)
- Erratum: Nitric oxide regulates synaptic transmission between spiny projection neurons (Proc Natl Acad Sci USA (2014) 111 49 (17636-17641) DOI: 10.1073/pnas.1420162111) (2015) (1)
- Role of Protein Phosphorylation in Regulation of Bioreactivity. (1985) (1)
- Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production (1997) (1)
- S.04.03 Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines (2006) (1)
- App Localization and Trafficking in the Central Nervous System (1998) (1)
- Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA. (1997) (1)
- GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease (2020) (1)
- RECEPTOR PHOSPHORYLATION: A ROLE FOR SECOND MESSENGERS? (1984) (1)
- Versatile selective kinase inhibitors: Chemistry and biology of indirubins (2012) (1)
- 1 DOPAMINE-AND cAMP-REGULATED PHOSPHOPROTEIN OF 32 kDa ( DARPP-32 )-DEPENDENT ACTIVATION OF ERK AND MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1 ( TORC 1 ) SIGNALING IN EXPERIMENTAL PARKINSONISM (2012) (1)
- Purification and characterization of cyclic GMP-dependent protein kinases. (1974) (1)
- Activation of the p11 Pathway by Antidepressants Induce AMPA Signaling (2021) (0)
- P.1.006 Neurogenic and chronic behavioural effects of fluoxetine are attenuated in p11 KO mice (2010) (0)
- Control of protein phosphate 1 in the dendrite (1999) (0)
- From a Nobel Perspective (2003) (0)
- Microsoft Word-1197974-file00.docx (2015) (0)
- METABOLISM, ACTIVITY AND SOME EFFECTS OF DRUGS IN MAMMALIAN NON-MYELINATED NERVE FIBERS: DISCUSSION TO PAPER BY H. McILWAIN (1965) (0)
- : Signals underlying moods , addictions , and brain disorders (2011) (0)
- Amino acid sequences surrounding the cAMP-dependent and calcium / calmodulin-dependent phosphorylation sites in rat and bovine synapsin I ( protein kinases / phosphoprotein / nervous system ) (0)
- Author response: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition (2017) (0)
- Foreword Paul Greengard, neurochemist with a vision (2004) (0)
- Protein Phosphorylation Regulates Processing of the Alzheimer β/A4-Amyloid Precursor Protein (1992) (0)
- P.1.10 Diverse psychotomimetics act through a common signaling pathway (2004) (0)
- Foreword Paul Greengard, neurochemist with a vision (2004) (0)
- Regulatory Agent: Cyclic AMP . G. Alan Robison, Reginald W. Butcher, and Earl W. Sutherland. With contributions by Th. Posternak and Joel G. Hardman. Academic Press, New York, 1971. xii, 532 pp., illus. $17.50. (1972) (0)
- Correction: Elevation of p11 in lateral habenula mediates depression-like behavior (2019) (0)
- Antipsychotic drugs: roles of cyclic AMP. (1975) (0)
- DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons (2022) (0)
- Alterations during aging of a striatal phosphatase cascade involved in reward systems (2010) (0)
- The neurobiology of dopamine signaling (2002) (0)
- Special issue dedicated to Dr. Paul Greengard. (1993) (0)
- Research Progress and Forecast Report (1984) (0)
- Intracellular Injection of Protein Kinase C Causes Changes Similar to Long-Term Potentiation (1988) (0)
- Rational development of a small-molecule activator of CK1γ2 that decreases C99 and beta-amyloid levels (2023) (0)
- Fifth International Conference on Cyclic Nucleotides and Protein Phosphorylation, Milan, June 27-July 1, 1983. (1984) (0)
- Assay of cyclic GMP by activation of cyclic GMP-dependent protein kinase. (1974) (0)
- DIFFERENTIAL LOCALIZATION OF PROTEIN PHOSPHATASE-1 (PP1) ISOFORMS AT AXOSPINOUS SYNAPSES: RESPONSE TO HALOPERIDOL AND COCAINE TREATMENT (2008) (0)
- Amyloid- Oligomers Are Inefficiently Measured by Enzyme-Linked Assay (2005) (0)
- Protein phosphorylation systems in postmortem human brain (2008) (0)
- Editorial Board (2011) (0)
- Regulatory Agent. (Book Reviews: Cyclic AMP) (1972) (0)
- Letter from Paul Greengard to Marshall W. Nirenberg (1979) (0)
- Biochemical characterization of the dopamine receptor in the mammalian caudate nucleus. (1974) (0)
- Protein Phosphorylation Regulates the Cellular Trafficking and Processing of the Alzheimer Beta/A4 Amyloid Precursor Protein (1993) (0)
- Phosphorylation of Endogenous Protein of Rat Brain by Cyclic Adenosine 3 ’ , S-Monophosphate-dependent Protein (1998) (0)
- THE SITES OF PHOSPHORYLATION ON C-SUBSTRATE FROM RABBIT CEREBELLUM AND THE MOLECULAR SPECIFICITIES OF CYCLIC CMP- AND CYCLIC AMP-DEPENDENT PROTEIN KINASES (1981) (0)
- Neuron-Glia Signaling Regulates the Onset of the Antidepressant Response (2021) (0)
- A Developmental Role for Microglial Presenilin 1 in Memory (2021) (0)
- Protein Kinase Substrate Proteins in Human Cerebrospinal Fluid (1987) (0)
- 798 PKC regulated amyloid precursor protein processing in Saccharomyces cerevisiae (1996) (0)
- Laterally diffusing dopamine 1 receptors are recruited to dendrtic spines by interaction with allosterically changed NMDA receptors (2005) (0)
- Fourth International Conference on Cyclic Nucleotides. Brussels, Belgium, July 22-26, 1980. (1981) (0)
- PROTEIN KINASES IN TIlE BRAIN (1985) (0)
- Insulin-regulated β-amyloid protein trafficking: Stimulated secretion and reduced intracellular accumulation of Aβ in neuronal cell cultures (2000) (0)
- and-DOPA Induced Dyskinesia LInhibition of mTOR Signaling in Parkinson ’ s Disease Prevents (2009) (0)
- Active Catalytic Fragment of Ca 2 + / Calmodulin-dependent Protein Kinase I 1 PURIFICATION (2001) (0)
- Proteolytic Processing of Human Amyloid /3 Protein Precursor in Insect Cells (2009) (0)
- Dopamine Receptor Response to NMDA Stimulation (2006) (0)
- P4-041 The Arctic Alzheimer mutation favors Aβ production by making APP less available to α-secretase at the cell surface (2006) (0)
- Phosphorylation of DARPP-32 by forskolin is potentiated by GABA in striatal slices (1992) (0)
- O4-02-04 The arctic APP mutation affects Aβ production and its site of cellular aggregation in Alzheimer's disease (2004) (0)
- [mGluR5: a receptor at the therapeutic crossroad?]. (2010) (0)
- Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements (2017) (0)
- P.2.b.019 Ablated neurogenic response to fluoxetine in female p11 knockout mice (2011) (0)
- Regulation of phosphorylation of proteins I , lila , and " ' b in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents ( calcium / cAMP / dopamine / fluphenazine ) (0)
- COCAINE-INDUCED EFFECTS ON MALE RAT SEXUAL BEHAVIOUR AND STRETCHING-YAWNING (1996) (0)
- Septal kindling increases the in situ phosphorylation state of synapsin I (1992) (0)
- Temporal characterisation of pro- and anti-apoptotic mechanisms following diffuse traumatic brain injury in rats (2002) (0)
- Second International Conference on Cyclic AMP, Vancouver, British Columbia, Canada, July 8-11, 1974 (1975) (0)
- Immunohistochemical localization 4 protein kinase in mammalian brain (Purkinje cell/protein phosphorylation/blood vessels/smooth muscle 4 (2016) (0)
- Encoding of an engram for food location by satiety-promoting Drd2 hippocampal neurons (2018) (0)
- RESPONSE ON "Diverse Psychotomimetics Act Through a CommonSignaling Pathway" (2004) (0)
- cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor (membrane channel/calmodulin/calcium) (2016) (0)
- Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin (2023) (0)
- Adenyl cyclase ; Cyclic nucleotide phosphodiesterases ; Protein kinase substrares ; Cyclic GMP ; The chemistry and biological properties of nucleotides related to nucleoside 3' 5' -cyclic phosphates ; Clinical studies and applications of cyclic nucleotides (1973) (0)
- Ca 2 +-dependent protein phosphorylation system in membranes from various tissues , and its activation by " calcium-dependent regulator " ( calcium / protein kinase ) (2004) (0)
- Drug interactions with cyclic nucleotide and protein phosphorylation systems. (1979) (0)
- REGULATION OF APPMETABOLISM BY PROTEIN PHOSPHORYLATION (1998) (0)
- Cellular Signals Converge at the Level of Protein Phosphorylation Pathways (1999) (0)
- Protein Phosphorylation Mechanisms in Disease (1999) (0)
- Dopamine-Sensitive Adenylate Cyclase inCaudate Nucleus ofRatBrain, andItsSimilarity tothe"DopamineReceptor" (extrapyramidal disease/ganglia/neurotransmitter/dihydroxyphenylalanine/Parkinson's (1972) (0)
- Bidirectional control of phospholipase A 2 activity by Ca 2 / calmodulin-dependent protein kinase II , cAMP-dependent protein kinase , and casein kinase II ( Eicosanolds / nerve terminals / neurotrasmltter release ) (0)
- 444 Expression of Alzheimer's disease associated genes in vitro and in vivo using viral vectors (1996) (0)
- Serotonin-Sensitive Adenylate Cyclase in r to the Serotonin Receptor: A Possible Sit( Acid Diethylamide (2016) (0)
- 89 – CYCLIC GMP LEVELS IN NEUROBLASTOMA CELLS ARE INCREASED BY DEPOLARIZATION AND BY MUSCARINIC RECEPTOR ACTIVATION (1978) (0)
- 389 Phosphorylation of APLP2 in cell cycle-dependent manner (1996) (0)
- Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2020) (0)
- Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression (2022) (0)
- Signal Transduction by Dopamine D1 Receptors (2002) (0)
- Correction: Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development (2021) (0)
- 322. Synapsin isoforms from primitive vertebrates: Evolutionary and functional significance (1996) (0)
- Regulation of MAP kinase activity and phosphorylation of synapsin I in presynaptic nerve terminals. (1996) (0)
- Correction for Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rapl activity and dendritic spine morphology (2010) (0)
- D-1 and D-2 Dopaminergic Receptors Regulate Phosphorylation of Synaptic Vesicle Phosphoproteins in Rat Neurohypophysis (1986) (0)
- Cyclic AMP-Dependent Endogenous Phosl Microtubule-Associated Protein (protein phosphorylation/in vitro assembly) (2017) (0)
- Adenosine 3':5'-cyclic monophosphate as a mediator in the action of neurohumoral agents. (1972) (0)
- Advances in Second Messenger and Phosphoprotein Research Vol. 23 (1990) (0)
- 176 Non-protease approaches to modulating APP processing: is there therapeutic relevance? (1996) (0)
- P3-314 Aβ42 accumulation in endosomes is associated with synaptic alterations (2004) (0)
- A conversation with Paul Greengard. Interview by Ushma S. Neill. (2013) (0)
- Serotonin receptor 4 in mature excitatory hippocampal neurons modulates mood and anxiety (2019) (0)
- 387 Identification of a protein which interacts with the cytoplasmic domain of the Alzheimer amyloid protein Precursor (1996) (0)
- Abstract # 1792 Peripheral inflammatory mediators and p11 levels in peripheral blood mononuclear cells from patients with Parkinson’s disease (2016) (0)
- Protein Serine-Threonine Kinases (1999) (0)
- Protein tyrosine phosphorylation in synaptic vesicles ( tyosine kinases / phosphotyrosine proteins / synaptophysin / nerve terminals ) (2003) (0)
- Synaptic vesicle-specific phosphoproteins: their possible role in the regulation of neurotransmitter release (1990) (0)
- THE TURKEY ERYTHROCYTE: A CATECHOLAMINE-RESPONSIVE CELL IN WHICH TO STUDY THE POSSIBLE ROLE OF PROTEIN PHOSPHORYLATION IN THE CONTROL OF CATION TRANSPORT (1979) (0)
- Short Communication Intraneuronal A b 42 Accumulation in Human Brain (1999) (0)
- Application of translating ribosome affinity purification to the comparative analysis of CNS cell types (2008) (0)
- Physiological apolipoprotein E epsilon-3 and epsilon-4 isoforms promote fibrillogenesis of A-beta in a thioflavine T assay (1995) (0)
- Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (62er4)) (2010) (0)
- Protein Serine-Threonine Phosphatases (1999) (0)
- Regulated phosphorylation of APP in vivo (1994) (0)
- Intrinsic heterogeneity of mossy cells mediates the differential crosstalk between the dorsal and ventral hippocampus (2020) (0)
- Molecular and cellular basis for the anti-amyloidogenic effects of estrogen (2000) (0)
- Cyclic Nucleotides, Phosphorylated Proteins and Drug Actions in the Central Nervous System (1979) (0)
- Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2019) (0)
- Premature Ovarian Failure: Detection of Ovarian Antibodies in the Sera of POF Patients by Dot Blot Immunoassay and ELISA (2008) (0)
- Molecular and Cellular Aspects of Major Depressive Disorder (2019) (0)
- Conversations with six leading neuroscientists on timely topics in brain research (2007) (0)
- [12] Assay of cyclic GMP by activation of cyclic GMP-dependent protein kinase (1974) (0)
- Dopamine-Sensitive Adenylate Cyclase in Site of Action of Antipsychotic Drugs (2016) (0)
- Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility (2022) (0)
- Protein phosphatase inhibitor-1 ablation results in depressed cardiac contractility in response to β-adrenergic stimulation and decreased phosphorylation of phospholamban (1999) (0)
- Neurochemical characterization of the autumnal neurogenesis in adult European starlings (2000) (0)
- Methods for treating amyloid related disorders and beta compositions thereof (2007) (0)
- Role of Casein Kinase 1 and DARPP-32 in Parkinson's Disease (2003) (0)
- Molecular cloning of the complementary dna for arpp 21 a cyclic amp regulated phosphoprotein enriched in the basal ganglia (1987) (0)
- 21 Regulated cleavage of amyloid-β precursor: Basic and clinical aspects (1996) (0)
- Investigation of the enantiomers of SK&F83959 in orofacial movements and effects of DARPP-32 'knockout' (2002) (0)
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Other Resources About Paul Greengard
What Schools Are Affiliated With Paul Greengard?
Paul Greengard is affiliated with the following schools:
- Johns Hopkins University
- Karolinska Institute
- Yeshiva University
- University of Cambridge
- National Chung Cheng University
- University of Amsterdam
- Institute of Cancer Research
- Florida State University
- University of Tokyo
- Riken
- Kurume University
- Cornell University
- Osaka University
- Paris Diderot University
- Duke University
- Yale University
- University of Milan
- Vanderbilt University
- Stanford University
- Rockefeller University
- Hamilton College