Paul I. W. De Bakker

Paul I. W. De Bakker's AcademicInfluence.com Rankings

Engineering

#7697

World Rank

#9104

Historical Rank

Biomedical Engineering

#777

World Rank

#789

Historical Rank

engineering Degrees

Paul I. W. De Bakker

Biology

#13996

World Rank

#17627

Historical Rank

Genetics

#1577

World Rank

#1683

Historical Rank

biology Degrees

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Engineering
Biology

Paul I. W. De Bakker's Degrees

PhD Biomedical Engineering University of Twente
Masters Applied Physics University of Twente

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Paul I. W. De Bakker's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PLINK: a tool set for whole-genome association and population-based linkage analyses. (2007) (25309)
A second generation human haplotype map of over 3.1 million SNPs (2007) (4567)
Integrating common and rare genetic variation in diverse human populations (2010) (2731)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (2011) (2511)
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study (2012) (2002)
Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
Risk alleles for multiple sclerosis identified by a genomewide study. (2007) (1380)
The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation (2010) (1129)
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. (2007) (1041)
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis (2011) (812)
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. (2011) (675)
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies (2012) (646)
High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis (2012) (595)
Mendelian randomization of blood lipids for coronary heart disease (2014) (580)
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2018) (578)
Pooled association tests for rare variants in exon-resequencing studies. (2010) (561)
Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens (2013) (554)
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. (2008) (551)
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data (2014) (547)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
Rare and low-frequency coding variants alter human adult height (2016) (511)
Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation (2010) (454)
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies (2012) (446)
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis (2016) (424)
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies (2008) (416)
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis (2012) (411)
Genome-wide patterns and properties of de novo mutations in humans (2015) (345)
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction (2010) (345)
Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci (2011) (327)
Evidence for an oligogenic basis of amyotrophic lateral sclerosis. (2012) (310)
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge (2014) (306)
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. (2012) (282)
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (2014) (260)
The Genome of the Netherlands: design, and project goals (2013) (260)
Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. (2004) (259)
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases (2009) (256)
Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects (2013) (252)
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (2012) (238)
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (2016) (234)
HLA-B*13:01 and the dapsone hypersensitivity syndrome. (2013) (232)
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 (2015) (214)
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci (2015) (199)
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk (2015) (199)
Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. (2014) (198)
Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes (2014) (190)
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. (2011) (190)
Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis (2011) (184)
Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis (2012) (174)
Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. (2014) (167)
Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms (2008) (159)
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases (2015) (156)
Genome-wide association analysis identifies multiple loci related to resting heart rate. (2010) (154)
Next-generation sequencing for HLA typing of class I loci (2011) (151)
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. (2014) (150)
Risk for myasthenia gravis maps to a 151Pro→Ala change in TNIP1 and to human leukocyte antigen‐B*08 (2012) (149)
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility (2015) (149)
Computational pan-genomics: status, promises and challenges (2016) (145)
Loci influencing blood pressure identified using a cardiovascular gene-centric array. (2013) (145)
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load (2015) (140)
Genome-wide association study identifies multiple susceptibility loci for diffuse large B-cell lymphoma (2014) (140)
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. (2014) (139)
Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all‐atom statistical potential and the AMBER force field with the Generalized Born solvation model (2003) (139)
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. (2013) (136)
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci (2017) (135)
A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility. (2015) (133)
Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls (2013) (133)
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. (2011) (133)
Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease (2015) (127)
HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis (2015) (125)
Characteristics of de novo structural changes in the human genome (2015) (113)
A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy. (2014) (112)
Behçet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity (2014) (112)
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. (2014) (101)
Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. (2007) (100)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (98)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018) (98)
Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands' (2014) (98)
52 Genetic Loci Influencing Myocardial Mass. (2016) (98)
A high-quality human reference panel reveals the complexity and distribution of genomic structural variants (2016) (96)
Molecular dynamics simulations of the hyperthermophilic protein sac7d from Sulfolobus acidocaldarius: contribution of salt bridges to thermostability. (1999) (94)
Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. (2013) (93)
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12 (2014) (90)
Interrogating the major histocompatibility complex with high-throughput genomics. (2012) (88)
Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study (2007) (86)
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia (2014) (85)
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. (2010) (83)
Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. (2014) (82)
Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017) (80)
Variation at HLA-DRB1 is associated with resistance to enteric fever (2014) (79)
Population-specific genotype imputations using minimac or IMPUTE2 (2015) (78)
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases (2016) (77)
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach (2014) (74)
Negative selection in humans and fruit flies involves synergistic epistasis (2016) (72)
Classical HLA-DRB1 and DPB1 Alleles Account for HLA Associations with Primary Biliary Cirrhosis (2012) (69)
Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck (2016) (68)
Cystatin C and Cardiovascular Disease (2016) (68)
Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies (2009) (67)
Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. (2012) (67)
PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION (2018) (67)
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data (2011) (66)
High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms (2014) (66)
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics (2014) (65)
Genetic variation at 16q24.2 is associated with small vessel stroke (2017) (61)
Multiethnic Genetic Association Studies Improve Power for Locus Discovery (2010) (61)
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity (2018) (61)
Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes (2013) (60)
Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency (2013) (58)
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis (2017) (58)
Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates. (2015) (58)
Agreement between TOAST and CCS ischemic stroke classification (2014) (58)
Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study (2017) (55)
A genome-wide association study of marginal zone lymphoma shows association to the HLA region (2015) (55)
Shared genetic contribution to ischemic stroke and Alzheimer's disease (2016) (55)
A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest (2017) (49)
Seventeen years of statin pharmacogenetics: a systematic review. (2016) (47)
Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies (2015) (46)
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. (2006) (46)
Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. (2010) (46)
Crystallographic refinement by knowledge-based exploration of complex energy landscapes. (2005) (46)
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits (2016) (45)
The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. (2009) (43)
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels (2015) (43)
Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. (2016) (42)
Advantages of fine-grained side chain conformer libraries. (2003) (39)
Sequence‐structure homology recognition by iterative alignment refinement and comparative modeling (2001) (38)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Amino Acid Position 11 of HLA-DRβ1 is a Major Determinant of Chromosome 6p Association with Ulcerative Colitis (2011) (36)
A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping. (2013) (35)
The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk. (2013) (34)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (33)
Knowledge-based real-space explorations for low-resolution structure determination. (2006) (31)
Impact of Inherited Genetic Variants Associated With Lipid Profile, Hypertension, and Coronary Artery Disease on the Risk of Intracranial and Abdominal Aortic Aneurysms (2013) (31)
Meta-analysis of genome-wide association studies. (2010) (30)
Accurate and fast multiple-testing correction in eQTL studies. (2015) (30)
Incremental value of a genetic risk score for the prediction of new vascular events in patients with clinically manifest vascular disease. (2015) (30)
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. (2013) (29)
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes (2018) (29)
Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN) (2014) (28)
Genetic risk load according to the site of intracranial aneurysms (2014) (28)
Conformer generation under restraints. (2006) (27)
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2018) (26)
Stroke genetics informs drug discovery and risk prediction across ancestries (2022) (26)
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. (2014) (26)
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits (2019) (26)
Discrete restraint‐based protein modeling and the Cα‐trace problem (2003) (25)
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting (2019) (24)
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study. (2015) (24)
Common variants at ten loci influence myocardial repolarization: the QTGEN consortium (2009) (23)
Evaluating the Impact of Functional Genetic Variation on HIV-1 Control (2017) (22)
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction (2015) (22)
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram (2016) (22)
IL28B Alleles Exert an Additive Dose Effect When Applied to HCV-HIV Coinfected Persons Undergoing Peginterferon and Ribavirin Therapy (2011) (22)
Towards a Molecular Systems Model of Coronary Artery Disease (2014) (21)
Serum Lipid Levels, Body Mass Index, and Their Role in Coronary Artery Calcification: A Polygenic Analysis (2015) (20)
A framework for the detection of de novo mutations in family-based sequencing data (2016) (20)
Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms (2016) (20)
Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques (2018) (19)
Rs964184 (APOA5-A4-C3-A1) Is Related to Elevated Plasma Triglyceride Levels, but Not to an Increased Risk for Vascular Events in Patients with Clinically Manifest Vascular Disease (2014) (18)
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols (2015) (15)
Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk (2016) (14)
Impact of carotid atherosclerosis loci on cardiovascular events. (2015) (13)
A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. (2016) (13)
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (2014) (13)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2020) (13)
Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms (2017) (13)
Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis (2013) (13)
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2019) (12)
Association Claims in the Sequencing Era (2014) (12)
Comparative modelling by restraint-based conformational sampling (2008) (11)
Selection and evaluation of Tag-SNPs using Tagger and HapMap. (2009) (10)
Genome‐wide association study of lymphoblast cell viability after clozapine exposure (2015) (9)
A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study (2017) (9)
Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study (2014) (9)
No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction. (2014) (8)
Discrete restraint-based protein modeling and the Calpha-trace problem. (2003) (7)
Discovering patterns of pleiotropy in genome-wide association studies (2018) (7)
Extensive Association of Common Disease Variants with Regulatory Sequence (2016) (7)
Common variants associated with blood lipid levels do not affect carotid plaque composition. (2015) (6)
Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017) (6)
No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after Cerebral Ischemia of Arterial Origin: The PROMISe Study (2015) (6)
Leveraging distant relatedness to quantify human mutation and gene conversion rates (2015) (4)
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene (2019) (4)
Towards a molecular systems model of coronary artery disease (2014) (3)
Exome-chip association analysis of intracranial aneurysms (2019) (3)
The multiple testing burden in sequencing-based disease studies of global populations (2016) (3)
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge (2014) (2)
Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity (2018) (1)
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution (2019) (1)
A statistical genetics guide to identifying HLA alleles driving complex disease (2022) (1)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries (2022) (1)
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity (2018) (1)
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits (2019) (1)
A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study (2017) (0)
PW03-010 - MHC complexity in Behçet's disease (2013) (0)
Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies (2015) (0)
OP0121 Analysis of the MHC Region in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies Independent Effects at HLA-DRB1 for the Most Common Subtypes of JIA (2015) (0)
Author Correction: A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study (2018) (0)
Rare loss of function variants in candidate genes and risk of colorectal cancer (2018) (0)
Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk (2016) (0)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018) (0)
A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
Correction: Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms (2009) (0)
Author Correction: A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study (2018) (0)
[Genome-wide association studies: methodology and interpretation for clinicians]. (2014) (0)
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2019) (0)
Reply: Poor Sensitivity and Specificity of Electrocardiographic Estimation of Myocardial Mass. (2017) (0)

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