Paul Saftig

Q: What Schools Are Affiliated With Paul Saftig

Paul Saftig is affiliated with the following schools: University of California, Berkeley, University of Oxford, KU Leuven, Kiel University, Institute of Science Tokyo, Stanford University, Juntendo University

Paul Saftig's AcademicInfluence.com Rankings

Paul Saftig

Computer Science

#4763

World Rank

#5028

Historical Rank

Computational Linguistics

#523

World Rank

#531

Historical Rank

Machine Learning

#1040

World Rank

#1056

Historical Rank

Artificial Intelligence

#1269

World Rank

#1293

Historical Rank

computer-science Degrees

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Computer Science

Paul Saftig's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Paul Saftig's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy (2007) (2668)
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain (1999) (2078)
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (1998) (1815)
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009) (1304)
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands (2004) (992)
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. (1998) (903)
Role for Rab7 in maturation of late autophagic vacuoles (2004) (877)
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice (2000) (863)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. (2002) (710)
Control of Peripheral Nerve Myelination by the ß-Secretase BACE1 (2006) (708)
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. (2003) (674)
Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009) (673)
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. (2011) (661)
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. (2005) (618)
At the acidic edge: emerging functions for lysosomal membrane proteins. (2003) (614)
LAMP proteins are required for fusion of lysosomes with phagosomes (2007) (593)
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death (2005) (532)
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) (530)
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. (1999) (524)
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) (2008) (512)
Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance (2010) (488)
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling (2005) (484)
LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase (2007) (462)
μ1A‐adaptin‐deficient mice: lethality, loss of AP‐1 binding and rerouting of mannose 6‐phosphate receptors (2000) (428)
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. (1995) (427)
Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)* (2003) (420)
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. (2009) (417)
The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation (2002) (380)
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice* (2005) (355)
The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex (2010) (350)
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). (2005) (344)
The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-γ and TNF-α and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10 1 (2004) (336)
Role of LAMP-2 in lysosome biogenesis and autophagy. (2002) (320)
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling (2000) (314)
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. (2001) (313)
Correction for Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx (2006) (305)
Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation (2004) (305)
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential? (2011) (291)
ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin (2008) (291)
Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis (2008) (291)
The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1* (2003) (284)
Acid β‐glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α‐synuclein processing (2011) (282)
Cathepsin D deficiency is associated with a human neurodegenerative disorder. (2006) (277)
β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase* (2005) (275)
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. (2009) (275)
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice (2010) (269)
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. (1998) (268)
Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch* (1999) (254)
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP (2002) (249)
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo (2009) (246)
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. (2004) (244)
Proteases involved in MHC dass II antigen presentation (1999) (244)
Molecular Determinants of KCNQ (Kv7) K+ Channel Sensitivity to the Anticonvulsant Retigabine (2005) (241)
Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy (2013) (239)
Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity (1998) (237)
Ectodomain shedding and ADAMs in development (2012) (231)
Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. (2008) (227)
Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation (2005) (226)
L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth (2005) (226)
Lassa virus entry requires a trigger-induced receptor switch (2014) (222)
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 (2006) (222)
Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization (2012) (220)
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36 (2013) (216)
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy. (1996) (216)
Thyroid functions of mouse cathepsins B, K, and L. (2003) (214)
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. (2000) (207)
The proteome of lysosomes (2010) (201)
LAMP-2: A control step for phagosome and autophagosome maturation (2008) (200)
Metalloproteases regulate T‐cell proliferation and effector function via LAG‐3 (2007) (189)
Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons (2000) (188)
Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption* (2009) (188)
ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase* (2009) (185)
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site (2010) (184)
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death (2007) (183)
Klotho is a substrate for α‐, β‐ and γ‐secretase (2009) (182)
Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone (2006) (176)
Lysosomal Membrane Proteins and Their Central Role in Physiology (2013) (174)
Pivotal role of cathepsin K in lung fibrosis. (2004) (173)
Normal Lysosomal Morphology and Function in LAMP-1-deficient Mice* (1999) (172)
Activity-Dependent Proteolytic Cleavage of Neuroligin-1 (2012) (171)
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain (2015) (170)
Regulated Shedding of Transmembrane Chemokines by the Disintegrin and Metalloproteinase 10 Facilitates Detachment of Adherent Leukocytes1 (2007) (169)
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein (2001) (169)
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway (2004) (167)
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice (2014) (164)
Evidence for a Critical Role of the Tumor Necrosis Factor α Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75NTR)* (2004) (155)
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology (2002) (150)
Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle (2008) (150)
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice (2003) (149)
Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b* (2008) (148)
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. (2002) (146)
Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly (1999) (145)
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling (2011) (145)
Bone density, strength, and formation in adult cathepsin K (-/-) mice. (2009) (142)
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy (2017) (137)
Klotho is a substrate for alpha-, beta- and gamma-secretase. (2009) (135)
Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. (2006) (135)
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment (2012) (134)
Elevation of β-Amyloid Peptide 2–42 in Sporadic and Familial Alzheimer's Disease and Its Generation in PS1 Knockout Cells* (2001) (132)
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury (2015) (131)
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles (2013) (127)
Evaluation of the Contribution of Different ADAMs to Tumor Necrosis Factor α (TNFα) Shedding and of the Function of the TNFα Ectodomain in Ensuring Selective Stimulated Shedding by the TNFα Convertase (TACE/ADAM17)* (2004) (127)
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation (2004) (125)
Ceramide as an activator lipid of cathepsin D. (2000) (124)
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. (2003) (123)
Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice. (2000) (122)
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function (2016) (120)
Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases (2019) (120)
Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by Difference Gel Electrophoresis (2006) (115)
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. (2001) (114)
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway (2017) (114)
Involvement of Nitric Oxide Released from Microglia–Macrophages in Pathological Changes of Cathepsin D-Deficient Mice (2001) (111)
Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions (2013) (110)
Regulated ADAM10-dependent Ectodomain Shedding of γ-Protocadherin C3 Modulates Cell-Cell Adhesion* (2006) (110)
Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP‐2 (2005) (109)
Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation (2011) (108)
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. (2013) (107)
ADAM 10 mediates E-cadherin shedding and regulates epithelial cell – cell adhesion , migration , and-catenin translocation (2005) (107)
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain (2013) (107)
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. (2013) (106)
Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function (2008) (106)
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo (2011) (105)
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10 (2012) (104)
Furin-, ADAM 10-, and γ-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of β-Catenin's Transcriptional Activity (2006) (103)
Disease model: LAMP-2 enlightens Danon disease. (2001) (101)
Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. (2010) (99)
Dimerization of β-Site β-Amyloid Precursor Protein-cleaving Enzyme* (2004) (98)
Early Embryonic Death of Mice Deficient in γ-Adaptin* (1999) (98)
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo (2017) (96)
Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D* (1996) (96)
The metalloproteinase ADAM10: A useful therapeutic target? (2017) (94)
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance (2014) (94)
Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis (2007) (93)
Spermatogenesis proceeds normally in mice without linker histone H1t (2000) (92)
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. (1999) (92)
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI. (1996) (91)
Synaptic Changes in the Thalamocortical System of Cathepsin D-Deficient Mice: A Model of Human Congenital Neuronal Ceroid-Lipofuscinosis (2008) (90)
Lysosomal membrane proteins: life between acid and neutral conditions. (2010) (90)
Cathepsin K Deficiency in Pycnodysostosis Results in Accumulation of Non-Digested Phagocytosed Collagen in Fibroblasts (2003) (89)
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. (2011) (88)
Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation (2011) (88)
Involvement of Cathepsin E in Exogenous Antigen Processing in Primary Cultured Murine Microglia* (2002) (87)
Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities. (2009) (87)
Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum (2005) (87)
Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10 (2009) (87)
Autophagic Vacuoles with Sarcolemmal Features Delineate Danon Disease and Related Myopathies (2005) (85)
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis. (2008) (85)
Structural Determinants of M-Type KCNQ (Kv7) K+ Channel Assembly (2006) (85)
Targeted disruption of the M(r) 46,000 mannose 6‐phosphate receptor gene in mice results in misrouting of lysosomal proteins. (1993) (84)
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. (2004) (83)
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. (2016) (82)
Autophagy in neuronal cells: general principles and physiological and pathological functions (2015) (80)
Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content (2012) (80)
Efficacy of enzyme replacement therapy in α-mannosidosis mice: a preclinical animal study (2004) (80)
Arrested maturation of Neisseria‐containing phagosomes in the absence of the lysosome‐associated membrane proteins, LAMP‐1 and LAMP‐2 (2007) (79)
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells (2004) (79)
Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins (2014) (78)
Impaired Phagosomal Maturation in Neutrophils Leads to Periodontitis in Lysosomal-Associated Membrane Protein-2 Knockout Mice1 (2008) (77)
Role for LAMP-2 in endosomal cholesterol transport (2009) (75)
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. (2011) (74)
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). (2004) (72)
The sheddase ADAM10 is a potent modulator of prion disease (2015) (72)
Cancer: Killing from the inside (2013) (71)
Mice Deficient in Lysosomal Acid Phosphatase Develop Lysosomal Storage in the Kidney and Central Nervous System* (1997) (70)
Cathepsin B-mediated Autophagy Flux Facilitates the Anthrax Toxin Receptor 2-mediated Delivery of Anthrax Lethal Factor into the Cytoplasm* (2009) (68)
Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice. (2008) (68)
Vacuolar ATPase in Phagosome-Lysosome Fusion (2015) (66)
Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice. (2008) (66)
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export (2019) (65)
Implication of APP secretases in notch signaling (2001) (64)
Reduced Sperm Count and Normal Fertility in Male Mice with Targeted Disruption of the ADP-Ribosylation Factor-Like 4 (Arl4) Gene (2002) (64)
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro. (2007) (64)
Natural Soluble Interleukin-15Rα Is Generated by Cleavage That Involves the Tumor Necrosis Factor-α-converting Enzyme (TACE/ADAM17)* (2004) (63)
Spermatogenesis in mice is not affected by histone H1.1 deficiency. (2000) (63)
Cholesterol Handling in Lysosomes and Beyond. (2020) (63)
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis (2020) (62)
How Lysosomes Sense, Integrate, and Cope with Stress. (2020) (62)
Cathepsin K Null Mice Show Reduced Adiposity during the Rapid Accumulation of Fat Stores (2007) (61)
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis (2008) (61)
Turn up the lysosome (2016) (60)
Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis (2005) (60)
Calvarial Osteoclasts Express a Higher Level of Tartrate-Resistant Acid Phosphatase than Long Bone Osteoclasts and Activation Does not Depend on Cathepsin K or L Activity (2006) (60)
Deafness in LIMP2‐deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis (2006) (60)
Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D Controls Listeria monocytogenes Intracellular Growth1 (2006) (58)
Parkinson's disease: acid‐glucocerebrosidase activity and alpha‐synuclein clearance (2016) (58)
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease (2015) (57)
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling (2006) (57)
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin (2012) (57)
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study. (2004) (56)
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. (2014) (55)
Cathepsin D is up‐regulated in inflammatory bowel disease macrophages (2004) (55)
Targeted Disruption of the Lysosomal α-Mannosidase Gene Results in Mice Resembling a Mild form of Human α-Mannosidosis (1999) (54)
Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways* (2010) (54)
ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses (2016) (53)
Diverse functions of the prion protein - Does proteolytic processing hold the key? (2017) (52)
The Tetraspanin CD63 Is Required for Efficient IgE-Mediated Mast Cell Degranulation and Anaphylaxis (2013) (51)
A Critical Histidine Residue Within LIMP‐2 Mediates pH Sensitive Binding to Its Ligand β‐Glucocerebrosidase (2012) (50)
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits (2011) (48)
The effect of cathepsin K deficiency on airway development and TGF-β1 degradation (2011) (47)
Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)* (2010) (47)
Natural history of alpha mannosidosis a longitudinal study (2013) (46)
Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction* (2009) (46)
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. (2004) (45)
Erratum: ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and β-catenin nuclear signalling (The EMBO Journal (2005) 24 (742-752)) (2005) (44)
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2 (2012) (44)
A role for cathepsin E in the processing of mast-cell carboxypeptidase A (2005) (44)
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). (2004) (44)
Mannose 6 Dephosphorylation of Lysosomal Proteins Mediated by Acid Phosphatases Acp2 and Acp5 (2011) (44)
Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes (2019) (43)
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina (2019) (43)
Signal‐peptide‐peptidase‐like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C‐terminal tail (2011) (43)
Molecular characterisation of ‘transmembrane protein 192’ (TMEM192), a novel protein of the lysosomal membrane (2010) (43)
The endolysosomal cysteine cathepsins L and K are involved in macrophage‐mediated clearance of Staphylococcus aureus and the concomitant cytokine induction (2014) (42)
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy (2007) (42)
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. (2015) (41)
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2 (2016) (41)
TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice (2015) (40)
Cathepsin K: a cysteine protease with unique kinin-degrading properties. (2004) (40)
Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function (2009) (39)
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A (2014) (38)
Decreased intracellular degradation of insulin‐like growth factor binding protein‐3 in cathepsin L‐deficient fibroblasts (2002) (38)
Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL (2011) (38)
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice. (2008) (38)
The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein (2016) (38)
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis. (2010) (37)
Altered Regulation of Phosphatidylinositol 3-kinase Signaling in Cathepsin D-Deficient Brain (2007) (35)
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15 (2018) (35)
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation Published, JLR Papers in Press, September 21, 2005. DOI 10.1194/jlr.M500131-JLR200 (2005) (35)
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice (2007) (34)
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice (2012) (34)
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study (2013) (34)
LAMP proteins account for the maturation delay during the establishment of the Coxiella burnetii‐containing vacuole (2016) (33)
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies (2017) (33)
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression (2019) (33)
Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development (2017) (33)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein (2018) (33)
Vacuolar ATPase in phago(lyso)some biology. (2017) (32)
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis. (1999) (32)
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
The Intramembrane Proteases Signal Peptide Peptidase-Like 2a and 2b Have Distinct Functions In Vivo (2014) (30)
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. (2020) (29)
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice. (1995) (29)
β-Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a β-Subunit-Like Fashion (2015) (29)
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks (2019) (29)
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules. (2009) (28)
Cathepsin K gene disruption does not affect murine aneurysm formation. (2010) (28)
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action. (2016) (28)
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. (2019) (27)
Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic (2006) (27)
Physiology of the lysosome (2006) (27)
Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease (2020) (27)
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D‐deficient mice (2005) (26)
Epidermal ADAM17 is dispensable for Notch activation (2013) (26)
LIMP-2 Links Late Phagosomal Trafficking with the Onset of the Innate Immune Response to Listeria monocytogenes (2010) (26)
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes. (2018) (25)
Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system (2013) (25)
SCARB2/LIMP2 deficiency in action myoclonus-renal failure syndrome. (2016) (25)
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban (2019) (25)
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. (2011) (24)
β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current (2011) (24)
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. (2016) (24)
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis (2006) (24)
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2. (2011) (24)
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex (2019) (23)
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. (2017) (23)
Cerebellar Alterations and Gait Defects as Therapeutic Outcome Measures for Enzyme Replacement Therapy in &agr;-Mannosidosis (2011) (23)
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells (2015) (23)
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing (2011) (23)
The NH2‐Terminal Transmembrane and Lumenal Domains of LGP85 are Needed for the Formation of Enlarged Endosomes/Lysosomes (2005) (22)
Presenilin Function in APP Processing (2000) (22)
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization. (1994) (22)
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice* (2016) (22)
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood–brain barrier (2015) (21)
ADAM 10 is a principal ‘ sheddase ’ of the low-affinity immunoglobulin E receptor CD 23 (2006) (21)
Mannose 6‐phosphate‐independent Lysosomal Sorting of LIMP‐2 (2015) (21)
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes (2017) (20)
Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. (2011) (20)
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon (2012) (20)
Altered morphological and electrophysiological properties of Cajal–Retzius cells in cerebral cortex of embryonic Presenilin‐1 knockout mice (2004) (20)
The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover (2018) (20)
A Cell‐Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases (2015) (20)
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. (2019) (18)
Live longer with LAMP-2 (2008) (18)
Alcadein cleavages by APP α - and γ -secretases generate small peptides p3-Alcs indicating Alzheimer disease-related γ -secretase dysfunction (2009) (18)
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II* (2017) (17)
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. (2014) (17)
The Intramembrane Protease SPPL2A Is Critical for Tooth Enamel Formation (2013) (17)
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40 (2020) (16)
Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules (2017) (16)
Haematopoietic development and immunological function in the absence of cathepsin D (2007) (16)
Natural soluble interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM17). (2011) (15)
Proteases at work: cues for understanding neural development and degeneration (2015) (15)
The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP (2019) (15)
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage (2019) (15)
Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). (2013) (15)
Biosynthesis of Phosphatidylcholine from a Phosphocholine Precursor Pool Derived from the Late Endosomal/Lysosomal Degradation of Sphingomyelin* (2001) (15)
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis (2016) (14)
Regulated Intramembrane Proteolysis of Bri 2 ( Itm 2 b ) by ADAM 10 and SPPL 2 a / SPPL 2 b * (2008) (13)
The function of presenilin-1 in amyloid β-peptide generation and brain development (1999) (13)
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles (2013) (13)
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease. (2015) (13)
No endogenous Aβ production in presenilin-deficient fibroblasts (2002) (13)
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis (2021) (13)
Intramembrane proteolysis within lysosomes (2016) (13)
Self‐assembly of the isolated KCNQ2 subunit interaction domain (2007) (12)
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice (2022) (12)
Adam10 haploinsufficiency causes freckle‐like macules in Hairless mice (2012) (11)
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment (2006) (11)
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments (2017) (11)
No endogenous A beta production in presenilin-deficient fibroblasts. (2002) (10)
Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice (2017) (10)
Cathepsin K Deficiency Suppresses Disuse‐Induced Bone Loss (2016) (10)
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies (2021) (9)
PLD3 and spinocerebellar ataxia. (2018) (9)
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice—An Animal Model of CLN10 Disease † (2021) (9)
Redundancy and Specificity of the Metalloprotease System Mediating Oncogenic NOTCH1 Activation in T-ALL. (2009) (9)
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models (2022) (9)
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis (2022) (9)
Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP). (2010) (8)
Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C (2000) (8)
Chronic enzyme replacement therapy ameliorates neuropathology in alpha‐mannosidosis mice (2015) (8)
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice (2017) (7)
LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development (2022) (7)
Deficiency of mannose 6‐phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice (2003) (7)
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes (1998) (7)
GPR37 is processed in the N‐terminal ectodomain by ADAM10 and furin (2021) (7)
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. (2021) (6)
ADAM10membrane protein ectodomain sheddase involved in regulated intramembrane proteolysis (2005) (6)
Functional characterization of the lysosomal membrane protein TMEM192 in mice (2017) (6)
LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro (2020) (6)
Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice (2022) (5)
Functional analysis of the angio-follicular unit of the mouse thyroid gland (2015) (5)
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis. (2021) (5)
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage (2021) (4)
Lysosomal Membrane Proteins (2005) (4)
Regulated intramembrane proteolysis--a story about sheddases and I-CliPs. (2009) (4)
Disintegrin-Like Metalloproteinase ADAM 10 and Shed by the Activity of the α and TNF-γ Ligand 16 Is Induced by IFN-The Transmembrane CXC-Chemokine Saftig (2004) (4)
for cell migration and for inflammatory leukocyte recruitment into the alveolar space (2014) (4)
Serum Starvation Induces BACE1 Processing and Secretion. (2016) (3)
Lysosome-targeted lipid probes reveal sterol transporters NPC1 and LIMP-2 as sphingosine transporters (2021) (3)
Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone (2021) (3)
Non-conventional role of lysosomal acid phosphatase in olfactory receptor axons: co-localization with growth-associated phosphoprotein-43 (1997) (3)
P4-172 Shedding of the ADAM10 ectodomain is mediated by ADAM9 and is followed by a processing of the ADAM10 CTF by presenilin/gamma-secretase (2004) (2)
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes (2023) (2)
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals (2022) (2)
Molecular Structural Determinants of M-Type KCNQ ( Kv 7 ) K Channel Assembly (2006) (2)
Inhibition of β-secretase Results in a Retinal Phenotype Involving Both the Vasculature and the RPE (2012) (2)
Corrigendum: The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein (2017) (2)
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin (2011) (2)
Adult Rat CA1 Pyramidal Cells Differentially Regulate the Intrinsic Excitability of Axo-Somatic and Apical Dendritic Kv7/M Channels (2015) (2)
Aβ 34 is a BACE 1-derived degradation intermediate associated with amyloid clearance and Alzheimer ’ s disease progression (2019) (2)
Degradation of Bone and the Role of Osteoclasts, Bone Lining Cells and Osteocytes (2011) (2)
Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation (2022) (2)
LAMP3 deficiency affects surfactant homeostasis in mice (2021) (2)
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15 (2018) (1)
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages (2022) (1)
g-secretase-like protease mediates release of Notch intracellulardomain (1999) (1)
15. Role of LAMP2 in neuronal autophagy (2009) (1)
The processing of the Amyloid-Precursor-Protein in presenilin-1 deficient neurons (1998) (1)
Acid phosphatase deficiency leads to accumulation of osteopontin in the subosteoclastic resorption area (2001) (1)
S-Palmitoylation determines TMEM55B-dependent positioning of lysosomes. (2021) (1)
Cathepsin D contributes to mucosal damage in inflammatory bowel disease (2003) (1)
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling the phenotype of human alpha-mannosidosis (1999) (1)
Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease. (2021) (1)
Intracellular compartments of pathogens: Highways to hell or stairways to heaven? (2017) (1)
P3-257: BACE1 cleavage and release of neuregulin-1 determines the ensheathment fate of axons (2006) (1)
Disrupted in renal carcinoma 2 ” ( DIRC 2 )-a novel transporter of the lysosomal membrane-is proteolytically processed by cathepsin L Short title : DIRC 2-a new lysosomal transporter (2017) (1)
LAMP-2step for phagosome and autophagosome maturation (2008) (1)
Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor. (2023) (1)
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling (2013) (0)
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles (2012) (0)
Phenotyping the mouse thyroid gland by semi-quantitative cell biology (2014) (0)
P4-226: LRP1 shedding in human brain: Roles of ADAM 10 and 17 (2008) (0)
Abstract 902: Lysosomal Integral Membrane Protein-2 is a Novel Component of the Intercalated Disc and Essential for a Compensatory Hypertrophic Response to Pressure-Overload (2006) (0)
CX3CL1-mediated cell-cell adhesion constitutive cleavage of CX3CL1 (fractalkine) and regulates The disintegrin-like metalloproteinase ADAM10 is involved in (2013) (0)
P2-084 BACE1 and BACE2 deficient mice (2004) (0)
organ-specific vascular structures Deletion of Adam 10 in endothelial cells leads to defects in (2011) (0)
Neuronal accumulation of lysobisphosphatidic acid in mice deficient for the lysosomal protease cathepsin D (2007) (0)
Linking thyroid and central nervous system functions of cathepsin K: Implications for non-classical thyroid regulation (2012) (0)
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice (2022) (0)
The Development of Urinary Biomarkers for Kidney Disease Is the Search for Our Renal Troponin (2009) (0)
ADAM10: α-secretase in Alzheimer’s disease and regulator of neurobiology (2014) (0)
Lysosomal biogenesis, animal models and autophagy (2009) (0)
Cathepsin K deficient mice have impaired bone resorption (1998) (0)
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of liver tissue homeostasis (2015) (0)
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40 (2020) (0)
Calvarial Osteoclasts Express a Higher Level of Tartrate-Resistant Acid Phosphatase Than Long Bone Osteoclasts and Activation Does not Depend on Cathepsin K or L Activity (2006) (0)
Molecular Genetics and Pathogenesis of Metachromatic Leukodystrophy (1997) (0)
NOD-like receptors-phagolysosomal compartments and PAMP recognition (2009) (0)
The two major familial Alzheimer's Disease gene products, presenilin 1 and amyloid precursor protein interact functionally (1998) (0)
The absence of Lamp2 triggers autophagy and mitochondrial biogenesis in skeletal muscle (2020) (0)
P2.22 Lamp-1 overexpression rescues cardiomyopathy in Lamp-2 deficient cells by correcting cellular lysosomal function (2010) (0)
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction (2022) (0)
Lysosomal Associated Membrane Protein-2 (LAMP-2) is Involved in Osteoblastic RANKL Signalling (2015) (0)
Apresenilin-1-dependent g-secretase-likeprotease mediates releaseofNotch intracellulardomain (1999) (0)
Modulation of the proteolytic processing of amyloid precursor protein (1999) (0)
Intracellular Growth Listeria monocytogenes Cathepsin-D Controls Phagosomal Mechanism Exerted by Cutting Edge : A Novel Nonoxidative (2006) (0)
Measuring learning and memory defects in lysosomal α-mannosidase deficient mice (2005) (0)
Behavioral defects in lysosomal alpha-mannosidase deficient mice (2005) (0)
Psychotiform behavioral alterations in a mouse model of human alpha-mannosidosis (2005) (0)
Receptor Signaling in Transitional B Cells Protease SPPL2a Is Critical for B Cell Processing of CD74 by the Intramembrane (2015) (0)
P2-121 In vivo consequences of BACE1 and BACE2 deficiency (2004) (0)
230: Unraveling the role of Adam17 in IL-6 trans-signaling (2013) (0)
Abstract 5490: Cathepsin K Deficiency does not Affect Murine Aneurysm Formation However it Reduces Macrophage-Rich Neointima Formation in Apoe-/-Mice (2008) (0)
P3-264 A soluble ADAM10 ectodomain is released by ADAM9 and acts as an active membrane protein sheddase and Abeta degrading enzyme (2006) (0)
Ultra-deep genome mutagenesis in haploid human cells (2016) (0)
A09 ADAM10 activity at the huntington’s disease presynapse (2021) (0)
Murine Microglia Antigen Processing in Primary Cultured Involvement of Cathepsin E in Exogenous REGULATION : ENZYME CATALYSIS (2002) (0)
CHAPTER 4 Lysosomal Membrane Proteins (0)
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies (2017) (0)
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression (2019) (0)
Myeloid A Disintegrin And Metalloprotease ADAM10 deficiency promotes atherosclerotic plaque stability by increasing fibrosis (2013) (0)
Misprocessing of Multiple Transmembrane Substrates Reveals Gamma-Secretase Dysfunction in Both Familial and Sporadic Alzheimer's Diseases (2009) (0)
P4-025 Characterization of primary secretase-like cleavages of alcadein (2006) (0)
Poster session: Multivariate behavioral alterations and hippocampal long-term potentiation in a mannosidosis murine model (2006) (0)
Functions of the protease bace1 in the maturation of the nervous system (2006) (0)
Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease (2022) (0)
Lysosomal-associated membrane protein-2 (LAMP-2) is involved in osteoblast-induced osteoclastogenesis (2015) (0)
The role of LAMP-2 in AβPP processing and Aβ degradation; implications for Alzheimer’s Disease (2015) (0)
Induktion von Cathepsin D in intestinalen Makrophagen bei Colitis (2015) (0)
T.P.5.11 Lamp1 overexpression may rescue cardiomyopathy in Lamp2 deficient mice (2009) (0)
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein (2018) (0)
Deﬁciency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function (cid:1) (2009) (0)
Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum (2011) (0)
P4-313 Presenilin-1 induces NF-κB activation via a RIP-P62-APKC signaling cascade (2004) (0)
Pathogenesis and Genetics of Metachromatic Leukodystrophy (1996) (0)
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis (2023) (0)
WO4-OR-4 ROLE OF CATHEPSIN K IN THE AORTIC WALL REMODELING DURING PROGRESSION OF ATHEROSCLEROSIS IN APOE-DEFICIENT MICE (2007) (0)
Cell biology of the beta-secretase BACE1 (2002) (0)
Lysosomal Membrane Defects (2012) (0)
45 Key role of the protease ADAM17 in the biology of interleukin-6, TNFα and the EGF-receptor (2008) (0)
Behavioral defects in lysosomal α-mannosidase deficient mice relate to the clinical profile of mannosidosis patients (2007) (0)
Author response: The sheddase ADAM10 is a potent modulator of prion disease (2015) (0)
of Adherent Leukocytes Metalloproteinase 10 Facilitates Detachment Chemokines by the Disintegrin and Regulated Shedding of Transmembrane (2007) (0)
Tissue and cell-type dependent impact of secondary glucocerebrosidase abnormalities due to LIMP-2 deficiency (2017) (0)
Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies (2021) (0)
Knockout Mice Lysosomal-Associated Membrane Protein-2 Neutrophils Leads to Periodontitis in Impaired Phagosomal Maturation in Eeva-Liisa Eskelinen and Paul Saftig (2007) (0)
LAMP3 is critical for surfactant homeostasis in mice (2021) (0)
Tu1858 Extracellular Cathepsin K is Protective Against Chronic Intestinal Inflammation in Mice and Involved in Host-Microbe Homeostasis (2012) (0)
Inhibition of lipopolysacharide induced osteoclast formation and bone resorption in vitro and in vivo in mice by cystatin C (2013) (0)
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10 (2012) (0)
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease (2015) (0)
Characterising the role of the lysosomal membrane proteins MFSD1 and TMEM106b in osteoclasts (2016) (0)
Rab GTPase-regulated phagosome-lysosome fusion is bypassed by micromolar calcium. (2023) (0)
Author response: The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP (2019) (0)
Role of Endothelial Cell Adam-10 In Murine Developmental Angiogenesis and Proliferative Retinopathies (2011) (0)

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