Paul Schimmel
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American chemist
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Paul Schimmelchemistry Degrees
Chemistry
#711
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#1203
Historical Rank
#310
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Organic Chemistry
#121
World Rank
#157
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#47
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Chemistry
Why Is Paul Schimmel Influential?
(Suggest an Edit or Addition)According to Wikipedia, Paul Reinhard Schimmel is an American biophysical chemist and translational medicine pioneer. Career Paul Schimmel is a Professor of Molecular Medicine at The Scripps Research Institute. Prior to joining The Scripps Research Institute, he was a John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics at MIT . Author or coauthor of many scientific research publications, he is also coauthor of a widely used 3-volume textbook on biophysical chemistry. His research interests have focused on aminoacyl tRNA synthetases as fundamental interpreters of the genetic information. Through career-long investigations of this ancient and universal set of essential enzymes, his laboratory has worked on a universal mechanism for correcting errors in the interpretation of genetic information, and went on to show how this mechanism is essential for maintaining cellular homeostasis and for preventing serious pathologies and disease. He has also been listed as one of the leading translational researchers in the world, having one of the top five most cited patents for the period 2012-2016.
Paul Schimmel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biophysical Chemistry: Part II: Techniques for the Study of Biological Structure and Function (1980) (988)
- Biophysical chemistry. Part III, The behavior of biologicalmacromolecules (1980) (678)
- Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration (2006) (537)
- A simple structural feature is a major determinant of the identity of a transfer RNA (1988) (521)
- Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs. (1979) (498)
- Two distinct cytokines released from a human aminoacyl-tRNA synthetase. (1999) (485)
- Aminoacyl tRNA synthetases: general scheme of structure-function relationships in the polypeptides and recognition of transfer RNAs. (1987) (448)
- An operational RNA code for amino acids and possible relationship to genetic code. (1993) (369)
- Bone marrow–derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis (2002) (336)
- Aminoacyl tRNA synthetases and their connections to disease (2008) (329)
- Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration (2014) (322)
- Enzyme structure with two catalytic sites for double-sieve selection of substrate. (1998) (317)
- Essential nontranslational functions of tRNA synthetases. (2013) (307)
- New functions of aminoacyl-tRNA synthetases beyond translation (2010) (281)
- The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis (2017) (277)
- Aminoacylation of RNA minihelices with alanine (1989) (265)
- A human aminoacyl-tRNA synthetase as a regulator of angiogenesis (2002) (258)
- Incorporation of nonnatural amino acids into proteins. (2004) (240)
- Conformational energies and configurational statistics of copolypeptides containing L-proline. (1968) (216)
- Specific sequence homology and three-dimensional structure of an aminoacyl transfer RNA synthetase. (1984) (210)
- Techniques for the study of biological structure and function (1980) (193)
- An Active Dominant Mutation of Glycyl-tRNA Synthetase Causes Neuropathy in a Charcot-Marie-Tooth 2D Mouse Model (2006) (186)
- Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine. (1972) (179)
- Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway (2001) (171)
- Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering. (2004) (167)
- Two Classes of tRNA Synthetases Suggested by Sterically Compatible Dockings on tRNA Acceptor Stem (2001) (164)
- Transfer RNA: From minihelix to genetic code (1995) (159)
- Aminoacyl tRNA synthetases as targets for new anti‐infectives (1998) (158)
- Elucidation of tRNA‐dependent editing by a class II tRNA synthetase and significance for cell viability (2003) (156)
- A fragment of human TrpRS as a potent antagonist of ocular angiogenesis (2002) (156)
- Nucleotide sequence of yeast LEU2 shows 5′-noncoding region has sequences cognate to leucine (1982) (155)
- Aminoacyl-tRNA synthetases: potential markers of genetic code development. (2001) (154)
- A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo. (1981) (151)
- Structural relationships and the classification of aminoacyl-tRNA synthetases. (1991) (149)
- Aminoacylation error correction (1996) (147)
- The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA (2009) (146)
- Deletion of an essential gene in Escherichia coli by site-specific recombination with linear DNA fragments (1984) (144)
- Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase (1983) (140)
- Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate. (1972) (140)
- Highly Differentiated Motifs Responsible for Two Cytokine Activities of a Split Human tRNA Synthetase* (1999) (138)
- Evidence for dispensable sequences inserted into a nucleotide fold. (1987) (138)
- Mutational isolation of a sieve for editing in a transfer RNA synthetase. (1994) (136)
- Identification of Four Genes Necessary for Biosynthesis of the Modified Nucleoside Queuosine* (2004) (135)
- Charcot–Marie–Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect (2007) (131)
- ATP-Directed Capture of Bioactive Herbal-Based Medicine on Human tRNA Synthetase (2012) (127)
- An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription (1981) (125)
- Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. (1991) (124)
- Structural switch of lysyl-tRNA synthetase between translation and transcription. (2013) (121)
- Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product. (1984) (121)
- Induction of Angiogenesis by a Fragment of Human Tyrosyl-tRNA Synthetase* (2002) (118)
- Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis (2012) (117)
- A new troponin T and cDNA clones for 13 different muscle proteins, found by shotgun sequencing (1983) (116)
- Photo-induced joining of a transfer RNA with its cognate aminoacyl-transfer RNA synthetase. (1974) (116)
- Global effects of mistranslation from an editing defect in mammalian cells. (2006) (113)
- Footprints of aminoacyl-tRNA synthetases are everywhere. (2000) (112)
- An Investigation of Water-Urea and Water-Urea-Polyethylene Glycol Interactions (1967) (111)
- The behavior of biological macromolecules (1980) (109)
- Conformational energy and configurational statistics of poly-L-proline. (1967) (108)
- Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation. (1994) (105)
- Human tRNA synthetase catalytic nulls with diverse functions (2014) (103)
- Enzymatic aminoacylation of an eight-base-pair microhelix with histidine. (1990) (103)
- Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid. (1972) (103)
- Functional expansion of human tRNA synthetases achieved by structural inventions (2010) (101)
- Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove (1992) (100)
- Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices. (1992) (99)
- 2 Rapid Reactions and Transient States (1970) (99)
- Transfer RNA in solution: selected topics. (1980) (98)
- Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution. (1989) (97)
- LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence (1988) (95)
- Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot–Marie–Tooth neuropathy (2009) (93)
- Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma (2009) (93)
- Primary structure of a large aminoacyl-tRNA synthetase. (1981) (93)
- Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases. (1977) (92)
- Translation of a Yeast Mitochondrial tRNA Synthetase Initiated at Redundant non-AUG Codons* (2004) (92)
- Human Tyr-tRNA synthetase is a potent PARP-1 activating effector target for resveratrol (2014) (91)
- Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe. (1974) (88)
- Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains (2003) (88)
- Major Biocontrol of Plant Tumors Targets tRNA Synthetase (2005) (88)
- 15. Aminoacyl-tRNA Synthetases (1974) (88)
- Parameters for the molecular recognition of transfer RNAs. (1989) (87)
- Identification of the tRNA-Dihydrouridine Synthase Family* (2002) (86)
- Crystal structure of a human aminoacyl-tRNA synthetase cytokine (2002) (86)
- Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA. (1974) (86)
- Discrete determinants in transfer RNA for editing and aminoacylation. (1997) (85)
- Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation (2008) (85)
- Development of tRNA synthetases and connection to genetic code and disease (2008) (84)
- VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function* (2005) (84)
- Chiral-Selective Aminoacylation of an RNA Minihelix (2004) (83)
- Genetic code in evolution: switching species‐specific aminoacylation with a peptide transplant (1998) (83)
- Long-range structural effects of a Charcot–Marie–Tooth disease-causing mutation in human glycyl-tRNA synthetase (2007) (82)
- Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase. (1991) (82)
- Functional assembly of a randomly cleaved protein. (1992) (81)
- Understanding structural relationships proteins of unsolved three‐dimensional structure (1990) (81)
- On the rate law and mechanism of the adenosine triphosphate--pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases. (1970) (79)
- Distinct domains of tRNA synthetase recognize the same base pair (2008) (79)
- Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase. (2005) (79)
- Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. (2012) (79)
- Purification and properties of alanine tRNA synthetase from Escherichia coli A tetramer of identical subunits. (1981) (79)
- Role of a tRNA Base Modification and Its Precursors in Frameshifting in Eukaryotes* (2007) (79)
- Retrovirus-Specific Packaging of Aminoacyl-tRNA Synthetases with Cognate Primer tRNAs (2002) (79)
- Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis. (1999) (78)
- LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes (1987) (78)
- Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA. (1995) (77)
- Crystal structures of two novel dye‐decolorizing peroxidases reveal a β‐barrel fold with a conserved heme‐binding motif (2007) (76)
- Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality (2010) (74)
- The C-Ala Domain Brings Together Editing and Aminoacylation Functions on One tRNA (2009) (72)
- Human Lysyl-tRNA Synthetase Accepts Nucleotide 73 Variants and Rescues Escherichia coli Double-defective Mutant* (1997) (72)
- Genetic code origins: tRNAs older than their synthetases? (1998) (72)
- Structure‐specific tRNA‐binding protein from the extreme thermophile Aquifex aeolicus (1999) (71)
- Genetic Code Ambiguity (2002) (71)
- Mutational separation of two pathways for editing by a class I tRNA synthetase. (2002) (71)
- Identification and structural characterization of heme binding in a novel dye‐decolorizing peroxidase, TyrA (2007) (70)
- The selective tRNA aminoacylation mechanism based on a single G•U pair (2014) (70)
- A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA. (1989) (69)
- Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo. (1989) (69)
- Evidence for interaction of an aminoacyl transfer RNA synthetase with a region important for the identity of its cognate transfer RNA. (1988) (69)
- Biophysical chemistry. Part I, The conformation of biologicalmacromolecules (1999) (69)
- Artificially ambiguous genetic code confers growth yield advantage. (2004) (69)
- PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications (2021) (69)
- Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases. (1987) (67)
- The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs (2015) (65)
- Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives (2000) (65)
- Possible role of aminoacyl-RNA complexes in noncoded peptide synthesis and origin of coded synthesis. (1994) (65)
- Classes of aminoacyl-tRNA synthetases and the establishment of the genetic code. (1991) (64)
- Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA. (1975) (64)
- The novel fragment of tyrosyl tRNA synthetase, mini‐ TyrRS, is secreted to induce an angiogenic response in endothelial cells (2008) (63)
- Laser cross-linking of protein-nucleic acid complexes (1991) (63)
- One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions. (2000) (63)
- Major Anticodon-binding Region Missing from an Archaebacterial tRNA Synthetase* (1999) (62)
- Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy (2014) (62)
- Two nuclear factors compete for the skeletal muscle actin promoter. (1987) (62)
- Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase. (1977) (62)
- Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB (2009) (61)
- Drug target validation: lethal infection blocked by inducible peptide. (2000) (61)
- Enzymatic aminoacylation of sequence-specific RNA minihelices and hybrid duplexes with methionine. (1992) (60)
- Crystal Structure of a Human Peptidyl-tRNA Hydrolase Reveals a New Fold and Suggests Basis for a Bifunctional Activity* (2004) (60)
- A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase (1990) (60)
- Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility (2000) (60)
- Reversal of creatine kinase translational repression by 3' untranslated sequences. (1990) (60)
- Natural Homolog of tRNA Synthetase Editing Domain Rescues Conditional Lethality Caused by Mistranslation* (2008) (59)
- Plasticity of Recognition of the 3′-End of Mischarged tRNA by Class I Aminoacyl-tRNA Synthetases* (2002) (58)
- Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases. (1975) (58)
- Chiral-selective aminoacylation of an RNA minihelix: Mechanistic features and chiral suppression (2006) (58)
- A domain for editing by an archaebacterial tRNA synthetase. (2004) (58)
- Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases. (1975) (57)
- Oligonucleotide-directed peptide synthesis in a ribosome- and ribozyme-free system. (2001) (56)
- A nucleotide that enhances the charging of RNA minihelix sequence variants with alanine. (1990) (55)
- A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase (1982) (54)
- An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response (2007) (54)
- DNA-binding site for two skeletal actin promoter factors is important for expression in muscle cells (1988) (54)
- RNA pseudoknots that interact with components of the translation apparatus (1989) (54)
- Nanosecond relaxation processes in aqueous mononucleoside solutions. (1971) (54)
- Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase (2002) (54)
- Getting tRNA synthetases into the nucleus. (1999) (53)
- Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. (1984) (53)
- Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor. (1991) (53)
- Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase. (1983) (53)
- Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells (2003) (53)
- Species Barrier to RNA Recognition Overcome with Nonspecific RNA Binding Domains* (1999) (52)
- Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (1994) (52)
- Relationship of two human tRNA synthetases used in cell signaling. (2004) (52)
- Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis (2006) (51)
- Maintaining genetic code through adaptations of tRNA synthetases to taxonomic domains. (1997) (51)
- Polypeptide sequences essential for RNA recognition by an enzyme. (1987) (50)
- Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase. (1989) (50)
- Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation. (1970) (50)
- Species-specific microhelix aminoacylation by a eukaryotic pathogen tRNA synthetase dependent on a single base pair. (1995) (50)
- Evidence for a unique first position codon-anticodon mismatch in vivo. (1988) (50)
- A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase. (2004) (50)
- Rescuing an essential enzyme–RNA complex with a non‐essential appended domain (1997) (49)
- A view into the origin of life: aminoacyl-tRNA synthetases (2000) (49)
- A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug. (1996) (49)
- RNA tetraloops as minimalist substrates for aminoacylation. (1992) (49)
- Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site (1984) (48)
- Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition. (2004) (47)
- Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. (1996) (47)
- Atomic Determinants for Aminoacylation of RNA Minihelices and Relationship to Genetic Code (1999) (47)
- Protein synthesis editing by a DNA aptamer. (1996) (47)
- Assembly of a class I tRNA synthetase from products of an artificially split gene. (1991) (46)
- An aminoacyl tRNA synthetase whose sequence fits into neither of the two known classes (2001) (45)
- Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid. (1972) (44)
- Crystal structure of Trbp111: a structure‐specific tRNA‐binding protein (2000) (44)
- Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase. (2007) (44)
- Discovery of a Gene Family Critical to Wyosine Base Formation in a Subset of Phenylalanine-specific Transfer RNAs* (2005) (44)
- Primary structure of histidine-tRNA synthetase and characterization of hisS transcripts. (1985) (43)
- Aminoacylation of alanine minihelices. "Discriminator" base modulates transition state of single turnover reaction. (1991) (43)
- Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS* (2008) (43)
- Operational RNA Code for Amino Acids in Relation to Genetic Code in Evolution* (2001) (43)
- Operational RNA code for amino acids: species-specific aminoacylation of minihelices switched by a single nucleotide. (1995) (43)
- Formation of two classes of tRNA synthetases in relation to editing functions and genetic code. (2001) (42)
- Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a (1990) (42)
- Antisense RNA complementary to 3' coding and noncoding sequences of creatine kinase is a potent inhibitor of translation in vivo. (1989) (42)
- Fragile T-stem in Disease-associated Human Mitochondrial tRNA Sensitizes Structure to Local and Distant Mutations* (2001) (42)
- Translocation within the acceptor helix of a major tRNA identity determinant (2001) (42)
- Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen. (1995) (41)
- Domain-domain communication in aminoacyl-tRNA synthetases. (2001) (41)
- Isolation, characterization and structural implications of a nuclease-digested complex of aminoacyl transfer RNA and Escherichia coli elongation factor Tu. (1977) (41)
- Specific atomic groups and RNA helix geometry in acceptor stem recognition by a tRNA synthetase. (1997) (40)
- Structural analyses clarify the complex control of mistranslation by tRNA synthetases. (2012) (40)
- Small RNA Oligonucleotide Substrates for Specific Aminoacylations (1995) (40)
- Secreted Histidyl-tRNA Synthetase Splice Variants Elaborate Major Epitopes for Autoantibodies in Inflammatory Myositis* (2014) (40)
- Hazards of deducing enzyme structure-activity relationships on the basis of chemical applications of molecular biology (1989) (39)
- Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo (1995) (38)
- Switching recognition of two tRNA synthetases with an amino acid swap in a designed peptide. (1995) (38)
- Errors from selective disruption of the editing center in a tRNA synthetase. (2000) (38)
- Genetic Code Ambiguity Confers a Selective Advantage on Acinetobacter baylyi (2007) (38)
- Activation of angiogenic signaling pathways by two human tRNA synthetases. (2002) (37)
- Mutational analysis suggests the same design for editing activities of two tRNA synthetases. (1996) (37)
- Peptide synthesis with a template-like RNA guide and aminoacyl phosphate adaptors (2003) (37)
- Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs. (1992) (37)
- Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase. (2000) (37)
- Species-specific tRNA recognition in relation to tRNA synthetase contact residues. (1997) (36)
- Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate. (1994) (36)
- A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities. (2007) (36)
- Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex (2011) (36)
- Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. (2006) (36)
- Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase. (1999) (35)
- Simultaneous binding of two proteins to opposite sides of a single transfer RNA (2001) (35)
- Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine. (2008) (35)
- Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity. (1985) (35)
- Two tissue-specific isozymes of creatine kinase have closely matched amino acid sequences. (1985) (34)
- Gain-of-function mutational activation of human tRNA synthetase procytokine. (2007) (34)
- Dipole moments in relation to configuration of polypeptide chains. (1967) (34)
- Evidence for a "cysteine-histidine box" metal-binding site in an Escherichia coli aminoacyl-tRNA synthetase. (1991) (34)
- Interaction of human hemoglobin with adenine nucleotides. (1969) (34)
- A large internal deletion converts yeast LEU3 to a constitutive transcriptional activator (1989) (34)
- Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA. (1975) (33)
- Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid (2017) (33)
- Mistranslation and its control by tRNA synthetases (2011) (33)
- Crystal Structure of an EMAP-II-Like Cytokine Released from a Human tRNA Synthetase (2003) (33)
- Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase. (2005) (33)
- Equilibrium measurements of the binding of cytidine 3'-phosphate to ribonuclease. (1965) (33)
- Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia (2018) (33)
- A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria. (2000) (33)
- Approaches to understanding the mechanism of specific protein-transfer RNA interactions (1977) (33)
- Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy (2017) (33)
- RNA binding determinant in some class I tRNA synthetases identified by alignment-guided mutagenesis. (1992) (32)
- Genetic Code Ambiguity CELL VIABILITY RELATED TO SEVERITY OF EDITING DEFECTS IN MUTANT tRNA SYNTHETASES* (2002) (32)
- An Escherichia coli tyrosine transfer RNA is a leucine-specific transfer RNA in the yeast Saccharomyces cerevisiae. (1991) (32)
- Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. (2012) (32)
- Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions. (1986) (32)
- Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. (2016) (32)
- Subtle atomic group discrimination in the RNA minor groove. (1997) (32)
- Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold. (1993) (32)
- Triple aminoacylation specificity of a chimerized transfer RNA. (1993) (32)
- Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs. (1977) (31)
- Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function (2018) (31)
- Cloning, partial sequencing, and in vitro transcription of the gene for alanine tRNA synthetase. (1981) (31)
- Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition. (1995) (30)
- Making connections: RNA-dependent amino acid recognition. (1995) (30)
- Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure. (1988) (30)
- Amino acid replacements that compensate for a large polypeptide deletion in an enzyme. (1985) (30)
- Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation. (1993) (30)
- Exiting an RNA world (2000) (30)
- Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases. (2003) (29)
- Chemical Relaxation Spectra: Calculation of Relaxation Times for Complex Mechanisms1 (1966) (29)
- An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo (1987) (29)
- Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. (1965) (29)
- Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase (2003) (28)
- Functional Redundancy in the Nonspecific RNA Binding Domain of a Class I tRNA Synthetase* (2000) (28)
- Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (1997) (28)
- Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution. (1993) (28)
- A Sephadex dialysis method of determining small molecule-macromolecule binding constants. (1965) (28)
- Dissociating Quaternary Structure Regulates Cell-signaling Functions of a Secreted Human tRNA Synthetase* (2011) (27)
- Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide. (2003) (27)
- GTP hydrolysis in protein synthesis: two for Tu? (1993) (26)
- Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA. (1976) (26)
- Insertion of new sequences into the catalytic domain of an enzyme. (1989) (26)
- Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure. (1994) (26)
- Mass spectra of partial protein hydrolysates as a multiple phase check for long polypeptides deduced from DNA sequences: NH2-terminal segment of alanine tRNA synthetase. (1980) (25)
- Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine. (1998) (25)
- Modular design of components of the operational RNA code for alanine in evolution. (1995) (25)
- Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response (2005) (25)
- A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters. (1990) (25)
- Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae. (1987) (24)
- ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase (2018) (24)
- Aminoacylation of RNA oligonucleotides: minimalist structures and origin of specificity (1993) (24)
- Structure-Based Phylogeny of Class IIa tRNA Synthetases in Relation to an Unusual Biochemistry (2001) (24)
- Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure (1993) (23)
- Hazards and their exploitation in the applications of molecular biology to structure-function relationships. (1990) (23)
- Dynamics of lysozyme-saccharide interactions. (1968) (23)
- Aminoacyl-tRNA synthetase-catalyzed cleavage of the glycosidic bond of 5-halogenated uridines. (1979) (23)
- Evidence that tRNA synthetase-directed proton transfer stops mistranslation. (2007) (23)
- Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. (2005) (22)
- A single base pair dominates over the novel identity of an Escherichia coli tyrosine tRNA in Saccharomyces cerevisiae. (1991) (22)
- Structure-specific tRNA Determinants for Editing a Mischarged Amino Acid* (2003) (22)
- Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex. (1999) (22)
- CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells (2019) (22)
- Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis. (1996) (22)
- Relaxation spectra of enzymatic reactions. (1967) (22)
- Microhelix aminoacylation by a class I tRNA synthetase. Non-conserved base pairs required for specificity. (1993) (22)
- Novel transfer RNAs that are active in Escherichia coli. (1992) (22)
- Purification of glutamine tRNA synthetase from Saccharomyces cerevisiae. A monomeric aminoacyl-tRNA synthetase with a large and dispensable NH2-terminal domain. (1993) (21)
- Effects of abnormal base ionizations on Mg2 plus binding to transfer ribonucleic acid as studied by a fluorescent probe. (1974) (21)
- Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine. (2002) (21)
- Origin of genetic code: A needle in the haystack of tRNA sequences. (1996) (21)
- Rabbit muscle creatine kinase: genomic cloning, sequencing, and analysis of upstream sequences important for expression in myocytes. (1991) (21)
- Transfer RNA conformation in solution investigated by isotope labeling. (1974) (21)
- Molecular dissection of a transfer RNA and the basis for its identity. (1989) (21)
- Activation of microhelix charging by localized helix destabilization. (1998) (21)
- RNA minihelices and the decoding of genetic information (1991) (21)
- Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame. (1982) (20)
- Isolated RNA binding domain of a class I tRNA synthetase. (1995) (20)
- Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution. (1992) (20)
- Genetic code origins: experiments confirm phylogenetic predictions and may explain a puzzle. (1999) (20)
- Base-analog-induced aminoacylation of an RNA helix by a tRNA synthetase (1995) (20)
- C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation. (1993) (20)
- Structure of transfer RNA-AMINOACYL TRANSFER RNA synthetase complexes investigated by nuclease digestion. (1975) (20)
- Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix. (1999) (20)
- Isolation of a functional human gene for brain creatine kinase. (1988) (20)
- Side Chain Independent Recognition of Aminoacyl Adenylates by the Hint1 Transcription Suppressor (2012) (19)
- Reconstruction of Quaternary Structures of Class II tRNA Synthetases by Rational Mutagenensis of a Conserved Domain (1997) (19)
- A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each. (1986) (19)
- Regulated Capture by Exosomes of mRNAs for Cytoplasmic tRNA Synthetases* (2013) (19)
- Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA. (1991) (18)
- Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS (2016) (18)
- An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution (1995) (18)
- C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase. (1996) (18)
- Analysis of the skeletal configuration of crystalline hen egg-white lysozyme. (1967) (18)
- RNA Determinants for Translational Editing (1999) (17)
- Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex (2020) (17)
- Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase. (2000) (17)
- Distinct ways of G:U recognition by conserved tRNA binding motifs (2018) (17)
- When protein engineering confronts the tRNA world. (1997) (17)
- Structure of a tryptophanyl-tRNA synthetase containing an iron–sulfur cluster (2010) (17)
- Nanosecond relaxation processes of phospholipid bilayers in the transition zone. (1978) (17)
- Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase. (1992) (17)
- Deletions in the large (beta) subunit of a hetero-oligomeric aminoacyl-tRNA synthetase. (1990) (17)
- Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase. (2010) (17)
- Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses (2019) (16)
- Region of a conserved sequence motif in a class II tRNA synthetase needed for transfer of an activated amino acid to an RNA substrate. (1994) (16)
- Dominant negative inhibition by fragments of a monomeric enzyme. (1996) (16)
- Acceptor stem and anticodon RNA hairpin helix interactions with glutamine tRNA synthetase. (1993) (16)
- Diverse RNA substrates for aminoacylation: clues to origins? (1998) (16)
- A mechanism for reducing entropic cost of induced fit in protein--RNA recognition. (1996) (16)
- RNA-RNA interactions between oligonucleotide substrates for aminoacylation. (1997) (16)
- Multiple new genes that determine activity for the first step of leucine biosynthesis in Saccharomyces cerevisiae. (1988) (15)
- Intron locations and functional deletions in relation to the design and evolution of a subgroup of class I tRNA synthetases (1992) (15)
- Dominant lethality by expression of a catalytically inactive class I tRNA synthetase. (1993) (15)
- A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition. (1992) (15)
- Introduction to transfer RNA (1977) (15)
- p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis (2011) (15)
- Relaxation spectra of the iron spin transition in methemoglobin. (1974) (15)
- Zinc-dependent cell growth conferred by mutant tRNA synthetase. (1994) (15)
- Mechanism of an aminoacyl transfer ribonucleic acid synthetase (1973) (15)
- Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA‐binding domains (1998) (15)
- Amino acid binding by the Class I aminoacyl‐tRNA synthetases: Role for a conserved proline in the signature sequence (1992) (15)
- Domain-domain communication in a miniature archaebacterial tRNA synthetase. (1999) (15)
- Tripartite functional assembly of a large class I aminoacyl tRNA synthetase. (1992) (14)
- A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase. (1986) (13)
- DNA APTAMER TARGETS TRANSLATIONAL EDITING MOTIF IN A TRNA SYNTHETASE (1997) (13)
- Molecular biology: Genetic code seizes pyrrolysine (2004) (13)
- Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability. (2008) (13)
- Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization. (1994) (13)
- Crystallization of a small fragment of an aminoacyl tRNA synthetase. (1988) (13)
- On the Calculation of Chemical Relaxation Amplitudes (1971) (12)
- Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases. (1999) (12)
- Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs (2020) (12)
- Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase. (1995) (12)
- An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function (2017) (12)
- Trbp111 selectively binds a noncovalently assembled tRNA-like structure (2002) (12)
- Assembly of a catalytic unit for RNA microhelix aminoacylation using nonspecific RNA binding domains. (1999) (12)
- Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease. (2006) (11)
- Synthetic RNA molecules as substrates for enzymes that act on tRNAs and tRNA-like molecules (1990) (11)
- Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion. (1988) (11)
- All You Need Is RNA (1998) (11)
- In vitro transcription of the histidine operon. Identification of the his promoter and leader and readthrough transcripts. (1981) (11)
- Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase. (1997) (11)
- Five specific protein-transfer RNA interactions. (1980) (11)
- Biological macromolecules and assemblies. Volume 3: Active sites of enzymes Edited by F. A. Jurnak and A. McPherson. New York: John Wiley & Sons. (1987). 564 pp. $84.95 (1987) (11)
- Functional expansion of the tRNA world under stress. (2011) (11)
- Synthesis and purification of oligoribonucleotides using T4 RNA ligase and reverse-phase chromatography. (1985) (10)
- Diversified sequences of peptide epitope for same-RNA recognition. (1993) (10)
- Complementary use of chemical modification and site-directed mutagenesis to probe structure-activity relationships in enzymes. (1988) (10)
- Who will watch the watchdogs? (1988) (10)
- RNA and DNA sequence recognition and structure-function of aminoacyl tRNA synthetases (1982) (10)
- Inhibition of an aminoacyl transfer RNA synthetase by a specific trinucleotide derived from the sequence of its cognate transfer RNA. (1977) (10)
- RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase (2003) (10)
- Cell growth inhibition by sequence‐specific RNA minihelices. (1995) (10)
- An Editing Activity That Prevents Mistranslation and Connection to Disease (2008) (10)
- Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA. (1990) (9)
- Erratum: VE-cadherin links tRNA synthetase cytokine to antiangiogenic function (Journal of Biological Chemistry (2005) 280 (2405-2408)) (2007) (9)
- CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS (2021) (9)
- Uncovering of a Short Internal Peptide Activates a tRNA Synthetase Procytokine* (2012) (9)
- A tipping point for mistranslation and disease (2009) (9)
- Release of aminoacyl transfer ribonucleic acid from transfer ribonucleic acid synthetase studied by rapid molecular sieve chromatography. (1973) (9)
- Microarrays of cells expressing de ® ned cDNAs (2001) (9)
- Positional recognition of a tRNA determinant dependent on a peptide insertion. (2004) (9)
- In Vitro Studies of Photochemically Cross-Linked Protein-Nucleic Acid Complexes. Determination of Cross-Linked Regions and Structural Relationships in Specific Complexes (1976) (8)
- 8 Aminoacyl tRNA Synthetases: From the RNA World to the Theater of Proteins (2006) (8)
- Two classes give lessons about CCA (2004) (8)
- Covalent enzyme-RNA complex: a tRNA modification that prevents a covalent enzyme interaction also prevents aminoacylation. (1985) (8)
- Interaction of Lysozyme with α-N-Acetyl-d-glucosamine (1969) (8)
- Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae (1985) (8)
- A metal‐binding motif implicated in RNA recognition by an aminoacyl‐tRNA synthetase and by a retroviral gene product (1992) (7)
- Variant of human enzyme sequesters reactive intermediate. (2005) (7)
- Similarities in the Structural Organization of Complexes of tRNAs with Aminoacyl-tRNA Synthetases and the Mechanism of Recognition (1979) (7)
- X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications (2021) (7)
- Effect of transfer ribonucleic acid on the rate law and mechanism of the adenosine triphosphate--pyrophosphate isotope exchange reaction of an aminoacyl transfer ribonucleic acid synthetase. (1972) (7)
- Reflections on the 20^ Taniguchi International Symposium - Tracing Biological Evolution in Protein and Gene Structures (2001) (7)
- An RNA binding site in a tRNA synthetase with a reduced set of amino acids. (1994) (7)
- Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases. (1979) (7)
- Proofreading by Isoleucyl-Transfer RNA Synthetase: Response (1999) (6)
- Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases. (1993) (6)
- Aminoacyl tRNA Synthetases (2002) (6)
- Incorporation of Non-natural Amino Acids (2003) (6)
- Ribozyme programming extends the protein code (2002) (6)
- Reconstruction of quaternary structures of class II tRNA synthetases by rational mutagenensis of a conserved domain. (1997) (6)
- Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase. (2010) (6)
- tRNA Structure Goes from L to λ (2003) (6)
- The RNP bridge between two worlds (2011) (6)
- Homeostatic mechanisms by alternative forms of tRNA synthetases. (2012) (6)
- DYNAMICS OF TAUTOMERIZATION OF FORMYCIN (1978) (6)
- Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase (2016) (5)
- p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish (2016) (5)
- The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target for Drug Development (2015) (5)
- Construction of intra-domain chimeras of aminoacyl-tRNA synthetases. (1989) (4)
- NONCOVALENT ASSEMBLY OF MICROHELIX RECOGNITION BY A CLASS II TRNA SYNTHETASE (1998) (4)
- Mutant enzymes and dissected tRNAs that elucidate motifs for protein-RNA recognition (1991) (4)
- Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid. (2001) (4)
- 'Distorted' RNA helix recognition (1996) (4)
- Communications to The Editor: Dipole Moments of Nonzwitterionic Polypeptide Chains (1970) (4)
- Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase. (1990) (4)
- tRNA structure goes from L to lambda. (2003) (4)
- Interpretation of Experiments that Delineate Transfer RNA Recognition in Vivo and in Vitro (1990) (3)
- Mapping the structure of specific protein-transfer RNA complexes by a tritium labeling method. (1979) (3)
- In biology, neither smaller nor larger is necessarily better (1985) (3)
- AB INITIO CALCULATIONS ON HYDROAROMATICS : HYDROGEN ABSTRACTION AND DISSOCIATION REACTION PATHWAYS (1999) (3)
- Non-covalent protein assembly (1993) (3)
- Genetic engineering: blessing or curse? (1978) (3)
- Active site of an aminoacyl-tRNA synthetase dissected by energy-transfer-dependent fluorescence. (2001) (3)
- Non-enzymatic aminoacylation of an RNA minihelix with an aminoacyl phosphate oligonucleotide. (2004) (3)
- Intermolecular proton transfer reaction between base and phosphate moieties of mononucleotides in solution. (1974) (3)
- Molecular Biology and the Transformation of Protein Science (1992) (3)
- Tracing Biological Evolution in Protein and Gene Structures: Proceedings of the 20th Taniguchi International Symposium, Division of Biophysics, Held in Nagoya, Japan, 31 October-4 November 1994 (1996) (3)
- Charging of RNA Microhelices and Decoding Genetic Information: Evaluation of Functional Coupling Between Distal Parts of a tRNA Structure (1993) (3)
- Subtle Functional Interactions in the RNA Minor Groove at a Nonessential Base Pair (1998) (3)
- Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA (2022) (3)
- SYNTHET ASES: GENERAL FEATURES AND RECOGNITION OF TRANSFER RNAS (1979) (2)
- ISOLEUCYL-TRNA SYNTHETASE (1999) (2)
- The endless frontier of tRNA synthetases (2020) (2)
- Aminoacyl-tRNA Synthetases as Clues to Establishment of the Genetic Code (2004) (2)
- Synthetic RNA Molecules as Substrates for Enzymes that Act on tRNAs and tRNA‐Like Molecules (1991) (2)
- Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis (1986) (2)
- The Figurative Fifties: New York Figurative Expressionism (1988) (2)
- Crystal Structure of Aquifex aeolicus Trbp111: a Structure-Specific tRNA Binding Protein (2003) (2)
- Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation (2020) (2)
- Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA. (2000) (2)
- Recent results on how aminoacyl transfer RNA synthetases recognize specific transfer RNAs (1979) (2)
- Author Correction: PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications (2021) (2)
- Peptides for RNA discrimination and for assembly of enzymes that act on RNA. (1997) (2)
- A DNA fragment with an a-phosphorothioate nucleotide at one end (2)
- Effect of 2-3-diphosphoglycerate and ATP on ethyl isocyanide binding to human hemoglobin. (1972) (2)
- Anticodon G recognition by tRNA synthetases mimics the tRNA core. (2013) (2)
- Perspectives: protein synthesis. All you need is RNA. (1998) (1)
- Industry benefits from the public funding of intellectual curiosity (2000) (1)
- [14] Photo-cross-linking of protein-nucleic acid complexes (1977) (1)
- Preface/Front Matter (1979) (1)
- Translation Silenced by Fused Pair of tRNA Synthetases (2004) (1)
- Affinity coelectrophoresis for dissecting protein-RNA domain-domain interactions in a tRNA synthetase system. (1996) (1)
- 1 New biology from ancient enzymes (2013) (1)
- Introducing New Amino Acids into Proteins (2002) (1)
- A universal plate format for increased throughput of assays that monitor multiple aminoacyl-tRNA synthetase activities (2013) (1)
- Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice (2019) (1)
- Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 (2021) (1)
- tRNA and Synthetases (2006) (1)
- Helter Skelter : L.A. Art in the 1990s (1992) (1)
- Perfecting the genetic code with an RNP complex. (2006) (1)
- Public Funding of Intellectual Curiosity (2000) (1)
- Ancient tRNA synthetase meets modern structural biology. (2009) (1)
- Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target (2023) (1)
- High priority scores. (1985) (1)
- Size polymorphism and the structure of aminoacyl-tRNA synthetases. (1984) (1)
- Alexander Rich (1924–2015) (2015) (1)
- Publisher Correction: ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase (2018) (1)
- The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements (2023) (1)
- Crystal structure of tyrosine bound human tyrosyl tRNA synthetase (2014) (1)
- Abstracts, Division of Biological Chemistry, 190th National Meeting of the American Chemical Society, September 8-13, 1985 (1985) (1)
- RNA Scaffolds for Minihelix-Based Aminoacyl Transfer: Design of “Transpeptizymes” (2000) (1)
- Synthesis of two polypeptide subunits of an aminoacyl tRNA synthetase as a single polypeptide chain. (1983) (1)
- Photo-cross-linking of protein-nucleic acid complexes. (1977) (1)
- The protein synthesis world. (2002) (1)
- Crystal Structure of tetrameric form of human lysyl-tRNA synthetase (2008) (1)
- Roles of extra c-terminal domain of higher eukaryotic tyrosyl-tRNA synthetases (1998) (0)
- Perception of an academic welfare state (1993) (0)
- Abstracts of papers presented at the Meeting on tRNA, August 23-August 27, 1978 (1978) (0)
- From tryptophanyl- trna synthetase derived polypeptides for the regulation of angiogenesis (2002) (0)
- Anticorps cationises administres a travers la barriere sang-cerveau (1988) (0)
- Minor Groove Recognition of the Critical Acceptor Helix Base Pair by an Appended Module of a Class II tRNA Synthetase. [Erratum to document cited in CA122:285491] (1995) (0)
- Crystal Structure of catalytic fragment of E. coli AlaRS G237A in complex with AlaSA (2009) (0)
- Bringing RNA back to the future (1999) (0)
- Protein synthesis editing by a DNA aptamer (accuracy of protein synthesis/amino acid discrimination/aminoacyl-tRNA synthetase/genetic code) (2016) (0)
- A fragment of a human tRNA synthetase (2016) (0)
- Aminoacyl tRNA synthetases as targets for new antiâ•’infectives (1998) (0)
- Human Mitochondrial Alanyl-tRNA Synthetase C-terminal domain (2020) (0)
- OBJECTives: The New Sculpture (1990) (0)
- Action, precision: The new direction in New York, 1955-60 (1984) (0)
- A human aminoacyl-tRNA syl of angiogenesis (2016) (0)
- Endothelial Progenitor Cell-Based Delivery of TrpRS Fragments Inhibits Retinal Angiogenesis (2002) (0)
- APPLICATIONS OF RAMAN SPECTROSCOPY by ROSEMARY SANCHES (2006) (0)
- Cationized antibody for the unsubscribe through the blood-brain barrier. (1988) (0)
- Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with AP4A) (2009) (0)
- Book Review: Thinking in Cases (2017) (0)
- Third Thoughts on Second Code (1988) (0)
- Corrections - Investigation of the Transfer of Amino Acid from a Transfer Ribonucleic Acid Synthetase-Aminoacyl Adenylate Complex to Transfer Ribonucleic Acid (1975) (0)
- INTERMOLECULAR PROTON TRANSFER REACTION BETWEEN BASE AND PHOSPHATE MOIETIES OF MONONUCLEOTIDES IN SOLUTION (1974) (0)
- Molecular Dissection of an Enzyme that Recognizes Transfer RNA (1980) (0)
- 22 – Mapping the Structure of Specific Protein-Transfer RNA Complexes by a Tritium Labeling Method (1981) (0)
- Proteins and Nucleotides: Structure and Conformation of Nucleic Adds and Protein-Nucleic Acid Interactions . Proceedings of a symposium, Madison, Wis., June 1974. M. Sundaralingam and S. T. Rao, Eds. University Park Press, Baltimore, 1975. xxiv, 752 pp., illus. $44.50. (1977) (0)
- A Bacterial AmberSuppressor inSaccharomyces cerevisiae Is Selectively Recognized byaBacterial Aminoacyl-tRNA Synthetase (1990) (0)
- Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain (2020) (0)
- Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP (2009) (0)
- The crystal structure of alanyl-tRNA synthetase in complex with L-alanine (2005) (0)
- Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure (2005) (0)
- Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase (2006) (0)
- Chimeric peptide for the delivery of neuro-peptides through the blood-brain-barrier. (1989) (0)
- Crystal structure of resveratrol bound human tyrosyl tRNA synthetase (2014) (0)
- Genetic code origins: Experiments and may explain a puzzle (2016) (0)
- Cost of failure to project impact of protein science on human health and economy (1993) (0)
- Advisory Board and Contents (2020) (0)
- High Priority Scores (1985) (0)
- Book Review:Entropy-Driven Processes in Biology. Polymerization of Tobacco Mosaic Virus Protein and Similar Reactions. Max A. Lauffer (1977) (0)
- Evolution and future of biotechnology (1988) (0)
- Book Review:Origins of Life on the Earth and in the Cosmos. Geoffrey Zubay (1997) (0)
- Chinese scientists and US leadership in the life sciences (2019) (0)
- Interaction of lysozyme with alpha-N-acetyl-D-glucosamine. (1969) (0)
- Advisory Board and Contents (2021) (0)
- New Biology from Natural Metamorphosis of a Conventional Class of Enzymes (2011) (0)
- Crystal Structure of catalytic fragment of E. coli AlaRS in complex with AMPPCP, Ala-AMP and PCP (2009) (0)
- ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase (2018) (0)
- Unraveling disease mechanisms in a Drosophila model for DI-CMTC neuropathy (2007) (0)
- Roche Travelling Professorship: Call for proposals (2009) (0)
- DNA Aptamer Targets Translational Editing Motif in a tRNA Synthetase. (1997) (0)
- CS6-5 A new class of cell signaling molecules derived from aminoacyl-tRNA synthetases (2010) (0)
- Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid (2018) (0)
- The selective tRNA aminoacylation mechanism based on a single G•U pair. (2018) (0)
- Crystal structure of bit1 (2003) (0)
- Areas of specialization of graduate research training grants may miss the big picture (1994) (0)
- Crystal structure of human HisRS (2012) (0)
- Method for the enlargement of the chemical composition of proteins produced in vivo using the mutant aminoacyl-tRNA synthetases without correction function (2002) (0)
- Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog (2009) (0)
- Proteins and nucleotides. (1977) (0)
- PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications (2021) (0)
- Crystal Structure of the C-Ala domain from Aquifex aeolicus alanyl-tRNA synthetase (2009) (0)
- GENES FOR TWO E. COLI AMINOACYL tRNA SYNTHETASES (1982) (0)
- Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol (2004) (0)
- Transfer RNA with double identity for in vitro kinetic modeling of transfer RNA identity in vivo. (1991) (0)
- Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity (2004) (0)
- Transfer RNA Conformation in Solution . (tritium labeling/radioactive fingerprint analysis/tertiar; (2016) (0)
- Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue (2013) (0)
- Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid (2018) (0)
- crystal structure of alanyl-tRNA synthetase in complex with ATP and magnesium (2005) (0)
- Inhibition of the transformation of the cells with increased purin-metabolic enzyme activity (1990) (0)
- The crystal structure of the catalytic fragment of the alanyl-tRNA synthetase (2004) (0)
- NMR solution structure of human HisRS splice variant (2013) (0)
- The crystal structure of the catalytic fragment of alanyl-tRNA synthetase in complex wtih glycine (2005) (0)
- Crystal structure of catalytic fragment of human AlaRS in complex with Aze-SA (2018) (0)
- Crystal Structure of the catalytic fragment of alanyl-tRNA synthetase in complex with L-serine (2005) (0)
- Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA (2018) (0)
- Crystal Structure of the catalytic fragment of alanyl-tRNA synthetase in complex with L-serine: Re-refined (2009) (0)
- M411_3c 107..110 (2001) (0)
- Structural Relationships in Macromolecular Complexes Determined By Photochemical Crosslinking (1977) (0)
- Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid (2017) (0)
- The dissection and engineering of sites that affect the activity of an enzyme of unknown structure. (1990) (0)
- The selective tRNA aminoacylation mechanism based on a single G•U pair (2014) (0)
- crystal structure of human tryptophanyl-tRNA synthetase (2004) (0)
- Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP (2009) (0)
- Crystal Structure of catalytic fragment of E. coli AlaRS in complex with AMPPCP (2009) (0)
- Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection (2022) (0)
- Aminoacylation-independent and cell-autonomous neuronal dysfunction (2009) (0)
- Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase (2003) (0)
- Publisher Correction: ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase (2018) (0)
- Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain (2020) (0)
- Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs (2020) (0)
- LEU3ofSaccharomyces cerevisiae Activates Multiple Genesfor Branched-Chain AminoAcidBiosynthesis byBinding toa CommonDecanucleotide CoreSequence (1988) (0)
- Extracellular Tyrosyl-tRNA Synthetase Is a Potent Stimulator of Thrombocytopoiesis (2016) (0)
- Multi-System Morbid Disease Associated With Mutations Ostensibly Affecting Non-Protein Synthesis Activities Of A tRNA Synthetase (2018) (0)
- A single base pair dominates over the novel identity of an Escherichia coli tyrosine tRNA in Saccharomyces cerevisiae (1991) (0)
- 1.2 Cantor and Schimmel – 30 Years Later (2012) (0)
- Transfer RNA: From Minihelix to Genetic Code Minireview (1995) (0)
- MIKE KELLEY 1954-2012. (2012) (0)
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Other Resources About Paul Schimmel
What Schools Are Affiliated With Paul Schimmel?
Paul Schimmel is affiliated with the following schools:
- Ochanomizu University
- University of Minnesota
- University of Tokyo
- University of Florida
- Utrecht University
- Massachusetts Institute of Technology
- Hong Kong University of Science and Technology
- Johns Hopkins University
- University of Illinois Urbana-Champaign
- National Central University
- Duke University
- Seoul National University
