Paul Talalay | Academic Influence

Paul Talalay's AcademicInfluence.com Rankings

Paul Talalay

Biology

#2545

World Rank

#4018

Historical Rank

Biochemistry

#246

World Rank

#307

Historical Rank

biology Degrees

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Biology

Paul Talalay's Degrees

Doctorate Medicine University of Chicago
PhD Biochemistry University of Chicago

Why Is Paul Talalay Influential?

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According to Wikipedia, Paul Talalay was the John Jacob Abel Distinguished Service Professor of Pharmacology and director of the Laboratory for Molecular Sciences at the Johns Hopkins School of Medicine in Baltimore. He was the founder of the Brassica Chemoprotection Laboratory for the study of edible plants that induce protective enzyme activity in the body and may help prevent the development of cancer.

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Paul Talalay's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. (1984) (6727)
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. (2001) (2628)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants (2002) (1801)
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. (1992) (1593)
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. (1997) (1258)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice (2001) (1133)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers (2004) (939)
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors (2002) (772)
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. (1980) (764)
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. (1994) (703)
Enzymic analysis of steroid hormones. (1960) (612)
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. (2010) (604)
Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. (2001) (588)
Analysis of combined drug effects: a new look at a very old problem (1983) (573)
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups (2001) (570)
Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. (1988) (553)
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. (2005) (544)
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. (1994) (519)
Chromogenic substrates; phenolphthalein glucuronic acid as substrate for the assay of glucuronidase activity. (1946) (492)
Direct and indirect antioxidant properties of inducers of cytoprotective proteins. (2008) (482)
Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. (1999) (461)
Chemoprotection against cancer by phase 2 enzyme induction. (1995) (452)
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. (2001) (448)
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. (1998) (430)
Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. (2005) (423)
Chemical and molecular regulation of enzymes that detoxify carcinogens. (1993) (408)
Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. (1988) (407)
Chemoprotection against cancer by induction of phase 2 enzymes. (2000) (395)
Rapid detection of inducers of enzymes that protect against carcinogens. (1992) (369)
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. (2002) (353)
Sulforaphane treatment of autism spectrum disorder (ASD) (2014) (341)
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. (1995) (305)
Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study (2006) (303)
Parallel Induction of Heme Oxygenase-1 and Chemoprotective Phase 2 Enzymes by Electrophiles and Antioxidants: Regulation by Upstream Antioxidant-Responsive Elements (ARE) (1995) (294)
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. (2007) (293)
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. (2003) (290)
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. (2013) (284)
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People's Republic of China (2005) (283)
Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. (1979) (272)
The electrophile counterattack response: protection against neoplasia and toxicity. (1993) (263)
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. (1995) (258)
On the mechanisms of induction of cancer-protective enzymes: a unifying proposal. (1985) (255)
Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. (1995) (241)
Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. (1999) (240)
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. (2000) (235)
Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function. (1962) (223)
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. (1998) (219)
Mechanisms of induction of enzymes that protect against chemical carcinogenesis. (1989) (216)
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. (2006) (214)
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. (2004) (213)
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. (1995) (205)
Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane (2001) (203)
SODIUM PHENOLPHTHALEIN PHOSPHATE AS A SUBSTRATE FOR PHOSPHATASE TESTS (1945) (195)
The Importance of Using Scientific Principles in the Development of Medicinal Agents from Plants (2001) (192)
Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation (2007) (192)
Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol. (1996) (191)
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations (2003) (181)
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China (2011) (176)
Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. (2000) (173)
Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. (1998) (169)
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases. (1956) (164)
Electrophilic tuning of the chemoprotective natural product sulforaphane (2010) (158)
The Chemical Diversity and Distribution of Glucosinolates and Isothiocyanates Among Plants (2001) (158)
Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone. (1987) (158)
The "Prochaska" microtiter plate bioassay for inducers of NQO1. (2004) (157)
Induction of the Phase 2 Response in Mouse and Human Skin by Sulforaphane-containing Broccoli Sprout Extracts (2007) (155)
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens. (1986) (154)
Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs (1984) (151)
Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. (1994) (146)
Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. (1994) (145)
Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China (2014) (143)
Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora (2012) (141)
Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols. (1992) (140)
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. (2005) (138)
An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings. (1999) (137)
Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. (2004) (137)
Corrigendum to “The chemical diversity and distribution of glucosinolates and isothiocyanates among plants” [Phytochemistry 56 (2001) 5–51]☆ (2002) (135)
Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates. (1996) (127)
Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver. (1977) (123)
Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1). (2004) (120)
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles (2008) (115)
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. (2012) (114)
Studies on the Ehrlich ascites tumor. I. The enzymic and metabolic activities of the ascitic cells and the ascitic plasma. (1951) (113)
Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase (2015) (112)
Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. (1983) (111)
Formation, functions and regulatory importance of S-adenosyl-L-methionine. (1970) (110)
Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine. (1970) (107)
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. (2005) (107)
Enzymic isomerization of Δ5-3-ketosteroids (1955) (107)
Reversible cold inactivation of a 17β-hydroxysteroid dehydrogenase of human placenta: Protective effect of glycerol (1966) (106)
Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase. (1989) (105)
An Exceptionally Potent Inducer of Cytoprotective Enzymes (2010) (104)
Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) (1997) (104)
Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (1999) (103)
Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues. (1990) (99)
NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase. (1996) (90)
ENZYMATIC MECHANISMS IN STEROID BIOCHEMISTRY. (1965) (89)
Chemoprotection against cancer by isothiocyanates and glucosinolates. (1996) (89)
Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates. (2004) (89)
Oxidative Degradation of Testosterone by Adaptive Enzymes (1952) (89)
ACTIVATION OF HYDROGEN TRANSFER BETWEEN PYRIDINE NUCLEOTIDES BY STEROID HORMONES. (1958) (88)
Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial (2016) (87)
Mechanism of inhibition of growth of 3T3-L1 fibroblasts and their differentiation to adipocytes by dehydroepiandrosterone and related steroids: role of glucose-6-phosphate dehydrogenase. (1989) (86)
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans (2015) (83)
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex (2007) (81)
The mechanism of the delta5-3-ketosteroid isomerase reaction: absorption and fluorescence spectra of enzyme-steroid complexes. (1963) (79)
Specificity, kinetics, and inhibition of alpha- and beta-hydroxysteroid dehydrogenases. (1956) (79)
The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations. (1991) (78)
Principles of the enzymatic measurement of steroids. (1957) (78)
[69] Hydroxysteroid dehydrogenases: Hydroxysteroid + DPN + (TPN+) ⇄ Ketosteroid DPNH (TPNH) + H+ (1962) (75)
Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants. (1987) (74)
Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins. (1983) (73)
The preparation and properties of crystalline delta5-3-ketosteroid isomerase. (1962) (73)
Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates. (2013) (73)
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation. (1959) (72)
Elevation of quinone reductase activity by anticarcinogenic antioxidants. (1982) (72)
Tissue-specific induction patterns of cancer-protective enzymes in mice by tert-butyl-4-hydroxyanisole and related substituted phenols. (1985) (71)
Enzymatic mechanisms in steroid metabolism. (1957) (70)
Neuroprotective effects of sulforaphane after contusive spinal cord injury. (2012) (68)
Studies on the microbiological degradation of steroid ring A. (1968) (67)
Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver. (1986) (67)
Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids. (1986) (66)
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention (2013) (66)
Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity. (1978) (66)
Molecular Mechanisms in Protection Against Carcinogenesis (1987) (63)
Isolation and sequencing of the gene encoding delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni: overexpression of the protein. (1987) (62)
Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase. (1993) (62)
Enzymatic formation of testololactone. (1963) (61)
Purification and properties of a beta-hydroxysteroid dehydrogenase. (1953) (61)
Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency (2017) (59)
Inhibition of NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue and related anthraquinone dyes: a structure-activity study. (1992) (59)
Notes from the Field: “Green” Chemoprevention as Frugal Medicine (2012) (57)
Purification and Properties of a 3a-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni (1965) (57)
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities (2007) (57)
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways (2015) (57)
The Δ5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition (1976) (55)
Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants. (2007) (53)
Bacterial oxidation of steroids. I. Ring A dehydrogenations by intact cells. (1959) (53)
Chemoprotective Glucosinolates and Isothiocyanates of Broccoli Sprouts (2001) (53)
Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols. (2008) (51)
Direct protective effect of NAD(P)H:quinone reductase against menadione-induced chemiluminescence of postmitochondrial fractions of mouse liver. (1987) (51)
Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance. (2013) (51)
Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction. (1990) (47)
ON A COENZYMATIC FUNCTION OF ESTRADIOL-17β (1958) (47)
The mechanism of S-adenosyl-L-methionine synthesis by purified preparations of bakers' yeast. (1972) (46)
Studies of the mechanism of the delta 5-3-ketosteroid isomerase reaction by substrate, solvent, and combined kinetic deuterium isotope effects on wild-type and mutant enzymes. (1990) (46)
Structures of mammalian cytosolic quinone reductases. (2000) (45)
Determination of the absolute configuration at the sulfonium center of S-adenosylmethionine. Correlation with the absolute configuration of the diastereomeric S-carboxymethyl-(S)-methionine salts. (1977) (45)
Protection against reactive oxygen species by NAD(P)H:quinone reductase induced by the dietary antioxidant butylated hydroxyanisole (BHA) (1984) (44)
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases. (1960) (42)
3 alpha-Hydroxysteroids as coenzymes of hydrogen transfer between di- and triphosphopyridine nucleotides. (1958) (41)
Regulatory properties of adenosine triphosphate-L-methionine S-adenosyltransferase of rat liver. (1973) (40)
Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention (2011) (40)
Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study (2017) (39)
Positioning of a spin-labeled substrate analogue into the structure of delta 5-3-ketosteroid isomerase by combined kinetic, magnetic resonance, and X-ray diffraction methods. (1987) (39)
Studies on the Walker tumor. I. Standardization of the growth of a transplantable tumor. (1952) (39)
Is oestrogenic activity present in hops? (1973) (38)
Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. (2010) (38)
Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates. (1991) (37)
The amino acid sequence of 5 -3-ketosteroid isomerase of Pseudomonas testosteroni. (1971) (37)
Concentration-dependent association of delta5-3-ketosteroid isomerase of Pseudomonas testosteroni. (1975) (36)
Studies on the enzymic hydroxylation of 3,4-benzpyrene. (1967) (36)
Isolation of novel microbial 3 alpha-, 3 beta-, and 17 beta-hydroxysteroid dehydrogenases. Purification, characterization, and analytical applications of a 17 beta-hydroxysteroid dehydrogenase from an Alcaligenes sp. (1985) (36)
Role of reduced glutathione in the Δ5-3-ketosteroid isomerase reaction of liver☆ (1976) (35)
14 – Dietary Carotenoids and their Metabolites as Potentially Useful Chemoprotective Agents against Cancer (1999) (35)
Microsomal 3α- and 11β-hydroxysteroid dehydrogenases☆ (1959) (35)
Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD). (2016) (35)
Stimulation of phagocytosis by sulforaphane. (2011) (33)
Studies on the Walker tumor. II. Effects of adrenalectomy and hypophysectomy on tumor growth in tube-fed rats. (1952) (33)
Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital. (2004) (33)
Mouse liver NAD(P)H:quinone acceptor oxidoreductase: Protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis (1994) (33)
M.D.‐Ph.D. training at the Johns Hopkins University School of Medicine, 1962‐1991 (1992) (33)
Transcription factors NRF2 and HSF1 have opposing functions in autophagy (2017) (32)
Participation of steroid hormones in the enzymatic transfer of hydrogen. (1960) (31)
Specificity of induction of cancer protective enzymes by analogues of tert-butyl-4-hydroxyanisole (BHA). (1985) (31)
Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects. (1991) (31)
Enzymatic estimation of steroids in human urine. (1958) (28)
Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase. (1966) (27)
Effect of inhibitors of adenosine triphosphate: L-methionine S-adenosyltransferase on levels of S-adenosyl-L-methionine and L-methionine in normal and malignant mammalian tissues. (1973) (26)
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. 3. Carbocyclic and heterocyclic amino acids. (1974) (25)
On the molecular specificity of steroid-enzyme combinations. The kinetics of β-hydroxysteroid dehydrogenase (1955) (25)
The enzymatic transfer of hydrogen. IV. The reaction catalyzed by a beta-hydroxysteroid dehydrogenase. (1955) (25)
Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice (2019) (25)
ENZYMATIC INTRODUCTION OF DOUBLE BONDS INTO STEROID RING A (1957) (24)
Partial purification of a beef adrenal delta-5-3-ketosteroid isomerase and studies of its mechanism of action. (1971) (23)
[31] Δ 5-3-ketosteroid isomerase of pseudomonas testosteroni (1969) (22)
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acids. (1979) (22)
John Jacob Abel and the Crystallization of Insulin (2015) (21)
Biosynthesis of pregnenolone from cholesterol by mitochondrial enzymes of bovine adrenal cortex. The question of the participation of the 20(22)-olefins and 20, 22-epoxides of cholesterol. (1978) (20)
Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct. (1981) (20)
The steroid specificity of the 17beta-hydroxysteroid dehydrogenase of human placenta. (1962) (19)
Preparation of highly purified 3α- and 3β-hydroxysteroid dehydrogenases from Pseudomonas sp (1979) (19)
Affinity chromatography of 3-oxosteroid Δ4-Δ5-isomerase of Pseudomonas testosteroni (1974) (19)
Enzymatic Formation of 3α-Hydroxysteroids (1954) (18)
A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice. (2008) (18)
Chemoprotection by inducers of electrophile detoxication enzymes. (1993) (18)
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes. (1995) (17)
Nobel prize in medicine or physiology (1967) (17)
Enzymatic oxidation of steroids by cell-free extracts of Pseudomonas testosteroni: isolation of cleavage products of ring A. (1965) (17)
The War against Cancer: New Hope (1999) (16)
Glucosinolates, Myrosinase, and Isothiocyanates: Three Reasons for Eating Brassica Vegetables (1998) (16)
Characterization of the three tyrosine residues of delta 5-3-ketosteroid isomerase by time-resolved fluorescence and circular dichroism. (1994) (15)
Preparation of crystalline delta-5-3-ketosteroid isomerase from Pseudomonas testosteroni. (1965) (15)
A one-step enzymatic assay for the measurement of 17 beta-hydroxy- and 17-oxo-steroid profiles in biological samples. (1986) (15)
The amino acid composition of crystalline delta-5-3-ketosteroid isomerase and its tryptic peptides. (1966) (15)
Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index. (2010) (15)
Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase. (1995) (14)
Nrf 2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans (2015) (14)
Erratum: The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: Mechanism of the two-electron reduction (Proceedings of the National Academy of Sciences of the United States of America (September 12, 1995) 92:19 (8846- 8850)) (1995) (14)
Structure and mechanism of cytosolic quinone reductases. (1999) (14)
Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors (2009) (14)
An active-site-directed irreversible inhibitor of 5 -3-ketosteroid isomerase. (1971) (13)
Linkage of an acetylenic secosteroid suicide substrate to the active site of delta 5-3-ketosteroid isomerase. Isolation and characterization of a tetrapeptide. (1981) (13)
A Fascination with Enzymes: The Journey Not the Arrival Matters (2005) (12)
Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni. (1982) (12)
Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids. (1981) (12)
Preliminary crystallographic X-ray data for an NAD(P)H:quinone reductase from mouse liver. (1986) (12)
Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding. (1995) (12)
An enzymatic derivative double isotope assay for L -methionine. (1971) (11)
Phenolic antioxidants as inducers of anticarcinogenic enzymes. (1992) (11)
Regulation of enzymes that detoxify the electrophilic forms of chemical carcinogens. (1990) (11)
Ultraviolet resonance Raman spectroscopy of delta 5-3-ketosteroid isomerase revisited: substrate polarization by active-site residues. (1995) (11)
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. I. Saturated and unsaturated aliphatic amino acids. (1974) (11)
Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. (2008) (11)
[71] Steroid-transforming enzymes (1974) (10)
Inhibition of deoxyribonucleic acid-directed ribonucleic acid polymerase by extracts of steroid-induced and noninduced Pseudomonas testosteroni. (1967) (10)
Enzymatic Estimation of Urinary Steroids.∗ (1956) (10)
Rat liver microsomal 3 alpha-hydroxysteroid dehydrogenase and dihydrodiol dehydrogenase: solubilization, separation and partial purification. (1986) (9)
Physiological interaction of cortisone acetate and diethylstilbestrol; lack of androgenic or estrogenic effects of cortisone acetate. (1952) (9)
Characterization of a monoclinic crystal form of an enzyme of steroid metabolism, Δ5-3-ketosteroid isomerase☆ (1976) (9)
18 Δ5-3-Ketosteroid Isomerase (1972) (8)
Enzymatic estimation of steroids in subpicomole quantities by hydroxysteroid dehydrogenases and nicotinamide nucleotide cycling. (1982) (7)
Activation of delta5-3-ketosteroid isomerase of bovine adrenal microsomes by serum albumins. (1979) (7)
A Simplified Method of Preparing Active Extracts of B-Glucuronidase. (1947) (7)
Bacterial Oxidation of Steroids * (2003) (6)
Purification and properties of a 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs. (1984) (6)
THE SCIENTIFIC CONTRIBUTIONS OF CHARLES BRENTON HUGGINS. (1965) (6)
Inhibition of ATP: L-methionine S-adenosyltransferase of bakers' yeast by structural analogues of ATP. (1973) (6)
Effects of adrenal steroid activator protein on the conversion of various 20- and 22-hydroxycholesterols to pregnenolone by adrenal mitochondrial enzymes. (1978) (6)
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. II. Aromatic amino acids. (1974) (6)
Crystalline Δ5-3-Ketosteroid Isomerase (1960) (5)
Inducers of Enzymes That Protect Against Carcinogens and Oxidants (2004) (5)
Natural and Synthetic Rubber Fibers. Electron Microscope Studies (1944) (5)
Erratum to “Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans” [Clin. Chim. Acta 316 (2002) 43–53] (2002) (5)
Apparatus for tube-feeding rats. (1952) (5)
Albert Lester Lehninger (1986) (4)
H. H. Dale's account of the standardization of insulin. (1992) (4)
Reply to Scahill: Behavioral outcome measures in autism (2015) (4)
Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial (2017) (4)
Erratum: Unexpected genetic and structural relationships of a long- forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase (Proceedings of the National Academy of Sciences of the United States of America (March 18, 1997) 94 (1669-1674)) (1997) (4)
Quantitation of isothiocyanates by cyclocondensation with 1,2-benzenedithiol (1993) (4)
1966 Nobel Laureates in Medicine or Physiology (1966) (3)
Core drilling by electromechanical drill (1993) (3)
On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase. (1980) (3)
Enzymic isomerization of delta5-3-ketosteroids. (1955) (3)
Enzymatic formation of 3 alpha-hydroxysteroids. (1954) (2)
Role of reduced glutathione in the delta(5)-3-kitosteroid isomerase reaction of liver. (1976) (2)
The delta 5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition. (1976) (2)
ON A COENZYMATIC FUNCTION OF ESTRADIOL-17beta. (1958) (2)
Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial. (2004) (2)
NMR docking of a spin-labeled substrate analog into the X-ray structure. delta. /sup 5/-3-ketosteroid isomerase (KSI) (1987) (2)
Restoration Of Bronchoprotection And Bronchodilation In Asthma Through Stimulation Of The Nrf2 Pathway (2010) (2)
Preparation of highly purified 3 alpha- and 3 beta-hydroxysteroid dehydrogenases from Pseudomonas sp. (1979) (2)
Steroid hormones and enzymatic hydrogen transport. (1960) (2)
Protection against UV-light-induced skin carcinogenesis by topical or dietary administration of broccoli sprout extracts as a source of sulforaphane in SKH-1 high-risk mice (2006) (2)
Albert Lester Lehninger (1917–1986): a perspective (1986) (1)
Catalysis of hydrogen transfer between pyridine nucleotides by 3α-hydroxysteroid dehydrogenase (1958) (1)
Pilot evaluation of sulforaphane in melanoma patients with multiple atypical nevi: Tissue STAT1 and STAT3 as risk markers. (2012) (1)
[51] Irreversible inhibitors of Δ5-3-ketosteroid isomerase: Acetylenic and allenic 3-oxo-5,10-secosteroids (1977) (1)
Isolation and identification of the principal inducer of anticarcinogenic protective enzymes from broccoli (1993) (1)
Increased Synthesis of Glutathione S-Transferases in Response Anticarcinogenic Antioxidants (2001) (1)
Effects of the administration of androgenic and estrogenic steroids on 3 alpha-hydroxysteroid dehydrogenase levels of the intact and castrated dog prostate. (1982) (1)
Conservation of laboratory animals by improved experimental design, generalized equations and computer analysis (1984) (1)
Mechanism of inhibition of growth of 3 T 3L 1 fibroblasts and their differentiation to adipocytes by dehydroepiandrosterone and related steroids : Role of glucose-6-phosphate dehydrogenase ( pentose phosphate pathway / 6-phosphogluconate / liposomes / epiandrosterone / 16 a-bromoepiandrosterone ) (2003) (1)
Design and Synthesis of Bifunctional Isothiocyanate Analogues of Sulforaphane: Correlation Between Structure and Potency as Inducers of Anticarcinogenic Detoxication Enzymes. (1994) (1)
Crystalline Delta 5-3-ketosteroid isomerase. (1960) (1)
Affinity chromatography of 3-oxosteroid delta4--delta5-isomerase of Pseudomonas testosteroni. (1974) (1)
Abstract LB-405: Modulation of the metabolism of air-borne pollutants by broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, People's Republic of China (2011) (1)
Quantification of skin erythema response to topical alcohol in alcohol‐intolerant East Asians (2017) (1)
Instructions for authors (2004) (1)
Induction of glutathione transferases (GT) and nad(P)H: quinone reductase (QR) in mouse tissues by substituted phenols (1984) (1)
Isolation of Novel Dehydrogenases Microbial 3 a-, 3 & , and 17 P-Hydroxysteroid PURIFICATION , CHARACTERIZATION , AND ANALYTICAL APPLICATIONS OF A 178-HYDROXySTEROID DEHYDROGENASE FROM AN ALCALIGENES sp (2001) (1)
Drugs in our society : based on a conference sponsored by the Johns Hopkins University (1964) (1)
THE ESTROGENIC ACTIVITY AND ENZYMATIC OXIDATION OF 17-BETA-ESTRADIOL-17-ALPHA-D. (1965) (0)
DETERMINE INDUCER OF THE STRUCTURAL FEATURES Cytoprotective Enzymes : ELUCIDATION An Exceptionally Potent Inducer of Signal Transduction : (2010) (0)
Relationship between the soluble glutathione-dependent A 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver ( human and rat liver / ligandin / isoelectric focusing ) (0)
Enhanced resistance to oxidative lung injury by an Nrf2‐ARE inducer in mice (2008) (0)
HUMAN QUINONE REDUCTASE TYPE 2 (1999) (0)
Kinetics, mechanism and inhibition of human quinone reductase type-2 (HQR2) (1997) (0)
The specificity of steroid‐enzyme interactions (1957) (0)
University of Dundee Transcription factors NRF 2 and HSF 1 have opposing functions in autophagy (2017) (0)
Anticarcinogenic azo dyes and phenolic antioxidants induce NAD(P)H: Quinone reductase (QR) in Hepa lclc7 murine hepatoma cells (1985) (0)
The three-dimensional structure of mouse NAD(P)H: quinone reductase expressed inE. coli (1996) (0)
V (2011) (0)
Characterization of monoclinic crystal form of an enzyme of steroid metabolism, delta5-3-ketosteroid isomerase. (1976) (0)
Tissue levels of L methionine (MET) and S adenosyl L methionine (ADO MET) and the effects on these levels of conformational analogues of MET (1973) (0)
Presentation of Dr. George Herbert Hitchings for the Passano Award. (1969) (0)
Chemo protective foods against cancer (1996) (0)
The chemopreventive power of crucifers: Isothiocyanates and glucosinolates (2008) (0)
Sulforaphane Inhibits Redox Fluorometry Shifts in Retinal Pigment Epithelium Cells Following Oxidative Challenge (2006) (0)
The Preparation and Properties of Crystalline A 5-3 Xetosteroid Isomerase * (2003) (0)
Inhibition of the Conversion of 3 T 3 Fibroblast Clones to Adipocytes by Dehydroepiandrosterone and Related Anticarcinogenic Steroids 1 (2006) (0)
HUMAN QUINONE REDUCTASE TYPE 2, COMPLEX WITH MENADIONE (1999) (0)
Irreversible inhibitors of delta5-3-ketosteroid isomerase: acetylenic and allenic 3-oxo-5,10-secosteroids. (1977) (0)
Instructions for Authors (2004) (0)
Catalysis of hydrogen transfer between pyridine nucleotides by 3 alpha-hydroxysteroid dehydrogenase. (1958) (0)
DETERMINATION OF THE ABSOLUTE CONFIGURATION AT THE SULFONIUM CENTER OF S-ADENOSYLMETHIONINE. CORRELATION WITH THE ABSOLUTE CONFIGURATION OF THE DIASTEREOMERIC S-CARBOXYMETHYL-(S)-METHIONINE SALTS (1978) (0)
Enzymatic Transport of Hydrogen by Estrogenic Hormones (1960) (0)
Questioning public funding of M.D.-Ph.D. programs (1992) (0)
Androgens, Estrogens, and the Mosaic Mouse (1978) (0)
Harnessing the anticancer power of plants. (2002) (0)
Irreversible Inactivation of AS-3-Ketosteroid Isomerase of Pseudomonas testosteroni by Acetylenic Suicide Substrates (2001) (0)
S-adenosylmethionine synthetase and s-adenosylmethionine levels in normal and malignant tissues, conformation of methionine from inhibition studies. Abstr. (1970) (0)
AFFINITY LABELING OF Δ5 -3-KETOSTEROID ISOMERASE FROM PSEUDOMONAS TESTOSTERONI (1981) (0)
Tissuesby Fumaric Acid Derivatives in Rodent Cells and Induction of Glutathione Transferases and NAD(P)H:Quinone (2013) (0)
QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX (1996) (0)
Affinity chromatography of steroid-transforming enzymes. (1974) (0)
Formulations de traitement au glucosinolate (2011) (0)
Studies on the Degradation of Ring A of Steroids by Microbial Enzymes (1969) (0)
Biochemical Contributions to Endocrinology: Experiments in Hormonal Research by Sir Charles Dodds, M.V.O. (review) (2015) (0)
Translating molecular targets for chemoprevention into interventions for at-risk populations (2007) (0)
Transcription factors NRF2 and HSF1 have opposing functions in autophagy (2017) (0)
Prostaglandins. Proceedings of the Second Nobel Symposium, Stockholm, June 1966. Sune Bergström and Bengt Samuelsson, Eds. Interscience (Wiley), New York; Almqvist and Wiksell, Stockholm, 1967. 299 pp., illus. $18.50 (1968) (0)
RAPID DETECTION OF INDUCERS OF ENZYMES THAT PROTECT AGAINST CARCINOGENS (2005) (0)
Prevention and treatment of oxidative-stress disorders with compounds which increase the intracellular glutathione of mirror or phase-ii-detoxification enzymes (2002) (0)
Identification of 2-oxo-cis-4-hexenoic acid as a cleavage product in the microbiological degradation of steroids. (1967) (0)
The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage (2016) (0)
Elucidation of intracellular signaling pathways in shear-activated chondrocytes: A role in arthritis (2005) (0)

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