Paulien Hogeweg
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Dutch theoretical biologist
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Biology
Paulien Hogeweg's Degrees
- PhD Theoretical Biology Utrecht University
- Masters Biology Utrecht University
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(Suggest an Edit or Addition)According to Wikipedia, Paulien Hogeweg is a Dutch theoretical biologist and complex systems researcher studying biological systems as dynamic information processing systems at many interconnected levels. In 1970, together with Ben Hesper, she defined the term bioinformatics as "the study of informatic processes in biotic systems".
Paulien Hogeweg's Published Works
Published Works
- Auxin transport is sufficient to generate a maximum and gradient guiding root growth (2007) (779)
- Root System Architecture from Coupling Cell Shape to Auxin Transport (2008) (392)
- Spiral wave structure in pre-biotic evolution: hypercycles stable against parasites (1991) (390)
- How amoeboids self-organize into a fruiting body: Multicellular coordination in Dictyostelium discoideum (2001) (275)
- Cellular automata as a paradigm for ecological modeling (1988) (270)
- The Roots of Bioinformatics in Theoretical Biology (2011) (261)
- Evolution of Evolvability in Gene Regulatory Networks (2008) (259)
- The alignment of sets of sequences and the construction of phyletic trees: An integrated method (2005) (229)
- Evolutionary Consequences of Coevolving Targets (1997) (154)
- Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model. (1985) (136)
- Modelling Morphogenesis: From Single Cells to Crawling Slugs. (1997) (133)
- The Cellular Potts Model and Biophysical Properties of Cells, Tissues and Morphogenesis (2007) (131)
- Multilevel Selection in Models of Prebiotic Evolution: Compartments and Spatial Self-organization (2003) (110)
- Energy directed folding of RNA sequences (1984) (109)
- Sympatric speciation and extinction driven by environment dependent sexual selection (1998) (101)
- Mirror Beyond Mirror: Puddles of Life (1987) (100)
- Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life. (2012) (98)
- Multilevel Selection in Models of Prebiotic Evolution II: A Direct Comparison of Compartmentalization and Spatial Self-Organization (2009) (95)
- Interactive instruction on population interactions. (1978) (92)
- The ontogeny of the interaction structure in bumble bee colonies: A MIRROR model (1983) (89)
- Feed-forward loop circuits as a side effect of genome evolution. (2006) (88)
- Shapes in the Shadow: Evolutionary Dynamics of Morphogenesis (1999) (84)
- Evolution of Networks for Body Plan Patterning; Interplay of Modularity, Robustness and Evolvability (2011) (82)
- Individual-oriented modelling in ecology (1990) (79)
- Chromosome rearrangements and the evolution of genome structuring and adaptability. (2007) (75)
- Evolution of complexity in RNA-like replicator systems (2008) (74)
- Error-threshold exists in fitness landscapes with lethal mutants (2007) (71)
- Metabolic adaptation after whole genome duplication. (2009) (71)
- Spatial pattern formation during aggregation of the slime mould Dictyostelium discoideum. (1996) (68)
- Colicin diversity: a result of eco-evolutionary dynamics. (1999) (67)
- Socioinformatic processes: MIRROR modelling methodology (1985) (66)
- A model study on biomorphological description (1974) (65)
- Computing an organism: on the interface between informatic and dynamic processes. (2002) (65)
- Phenotypic error threshold; additivity and epistasis in RNA evolution (2005) (63)
- On the Origin of DNA Genomes: Evolution of the Division of Labor between Template and Catalyst in Model Replicator Systems (2011) (61)
- Interactions between macrophages and T-lymphocytes: tumor sneaking through intrinsic to helper T cell dynamics. (1986) (59)
- Self-reinforcing spatial patterns enslave evolution in a host-parasitoid system. (1997) (59)
- The impact of long-distance horizontal gene transfer on prokaryotic genome size (2009) (56)
- The RNA Silencing Pathway: The Bits and Pieces That Matter (2005) (56)
- In silico evolved lac operons exhibit bistability for artificial inducers, but not for lactose. (2006) (55)
- Phototaxis during the slug stage of Dictyostelium discoideum: a model study (1999) (53)
- Modelling Dictyostelium discoideum morphogenesis: The culmination (2002) (52)
- Self-Structuring in Artificial "Chimps" Offers New Hypotheses for Male Grouping in Chimpanzees (1994) (52)
- Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome (2003) (50)
- The Effect of Stochasticity on the Lac Operon: An Evolutionary Perspective (2007) (48)
- Morphogengineering roots: comparing mechanisms of morphogen gradient formation (2012) (45)
- Virtual Genomes in Flux: An Interplay of Neutrality and Adaptability Explains Genome Expansion and Streamlining (2012) (43)
- Moving Forward Moving Backward: Directional Sorting of Chemotactic Cells due to Size and Adhesion Differences (2006) (42)
- Spatially induced speciation prevents extinction: the evolution of dispersal distance in oscillatory predator-prey models (1998) (41)
- The Role of Complex Formation and Deleterious Mutations for the Stability of RNA-Like Replicator Systems (2007) (39)
- Multilevel evolution: replicators and the evolution of diversity (1994) (39)
- Information integration and red queen dynamics in coevolutionary optimization (2000) (38)
- Immunological discrimination between self and non-self by precursor depletion and memory accumulation. (1987) (37)
- The origin of a primordial genome through spontaneous symmetry breaking (2017) (37)
- The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation (2009) (37)
- Two predators and one prey in a patchy environment: An application of MICMAC modelling (1981) (37)
- Diet traditions and cumulative cultural processes as side-effects of grouping (2008) (36)
- Space and the persistence of male–killing endosymbionts in insect populations (2002) (35)
- From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics. (2020) (34)
- Tumor escape from immune elimination: simplified precursor bound cytotoxicity models. (1985) (34)
- Evolution of resource cycling in ecosystems and individuals (2009) (30)
- Niche Packing and Number of Species (1980) (30)
- Pattern generation in molecular evolution: Exploitation of the variation in RNA landscapes (1994) (29)
- The role of mutational dynamics in genome shrinkage. (2007) (28)
- Segment-Specific Adhesion as a Driver of Convergent Extension (2015) (28)
- Redundant Coding of an NP-Complete Problem Allows Effective Genetic Algorithm Search (1990) (27)
- Evolution of evolvability and phenotypic plasticity in virtual cells (2017) (27)
- Coevolution of gene families in prokaryotes. (2008) (27)
- A Synergism between Adaptive Effects and Evolvability Drives Whole Genome Duplication to Fixation (2014) (27)
- Toward a theory of multilevel evolution: long-term information integration shapes the mutational landscape and enhances evolvability. (2012) (26)
- On searching generic properties of non generic phenomena: an approach to bioinformatic theory formation (1998) (26)
- From population dynamics to ecoinformatics: Ecosystems as multilevel information processing systems (2007) (25)
- Large changes in regulome size herald the main prokaryotic lineages. (2007) (25)
- Resource distributions and diet development by trial-and-error learning (2006) (24)
- Cultural inheritance and diversification of diet in variable environments (2009) (24)
- Evolution of Functional Diversification within Quasispecies (2014) (22)
- Evolutionary Dynamics and the Coding Structure of Sequences: Multiple Coding as a Consequence of Crossover and High Mutation Rates (1992) (22)
- In silico evo-devo: reconstructing stages in the evolution of animal segmentation (2016) (21)
- Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements (2020) (20)
- Growth and Recruitment in the Immune Network (1992) (20)
- Idiotypic networks incorporating T-B cell co-operation. The conditions for percolation. (1989) (19)
- Individual-and population-based diversity in restriction-modification systems (2000) (19)
- Selective advantages of syntactic language - a model study (2001) (18)
- Oligothetic characterisation of clusters (1981) (17)
- The evolution of strand preference in simulated RNA replicators with strand displacement: Implications for the origin of transcription (2008) (17)
- Sequential Predation: A Multi-model Study (1995) (17)
- Parasites Sustain and Enhance RNA-Like Replicators through Spatial Self-Organisation (2016) (16)
- The dynamics and efficacy of antiviral RNA silencing: A model study (2008) (16)
- Eco-evolutionary dynamics, coding structure and the information threshold (2010) (15)
- RNA silencing can explain chlorotic infection patterns on plant leaves (2008) (15)
- High cost enhances cooperation through the interplay between evolution and self-organisation (2016) (15)
- Evolutionarily stable disequilibrium: endless dynamics of evolution in a stationary population (2016) (14)
- Evolution as pattern processing: TODO as substrate for evolution (1991) (13)
- Self-nonself discrimination due to immunological nonlinearities: the analysis of a series of models by numerical methods. (1987) (13)
- In Silico Gene-Level Evolution Explains Microbial Population Diversity through Differential Gene Mobility (2015) (13)
- Co-evolution and ecosystem based problem solving (2012) (12)
- Randomness and pattern scale in the immune network (2018) (12)
- Multilevel processes in evolution and development: Computational models and biological insights (2002) (12)
- Contingent evolution of alternative metabolic network topologies determines whether cross-feeding evolves (2020) (12)
- Evolutionary Stagnation Due to Pattern-Pattern Interactions in a Coevolutionary Predator-Prey Model (1997) (12)
- Problem-solving environments for biological morphogenesis (2006) (11)
- Crowns Crowding: An Individual Oriented Model of the Acanthaster Phenomenon (1990) (11)
- Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age (2012) (10)
- Conceptualizing the origin of life in terms of evolution (2017) (10)
- Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives (2019) (10)
- Resource distributions affect social learning on multiple timescales (2009) (9)
- Modelling the dynamics of viral suppressors of RNA silencing (2012) (9)
- The role of speciation in spatial coevolutionary function approximation (2007) (8)
- Regulome size in Prokaryotes: universality and lineage-specific variations. (2009) (8)
- Around the clock: gradient shape and noise impact the evolution of oscillatory segmentation dynamics (2018) (8)
- Models of Dictyostelium discoideum Aggregation (1997) (7)
- Genetic Algorithms and Information Accumulation during the Evolution of Gene Regulation (1989) (7)
- Self-Organisation and Evolution of Social Systems: Interlocking of self-organisation and evolution (2005) (7)
- Mutation Rates and Evolution of Multiple Coding in RNA-based Protocells (2014) (6)
- Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure (2019) (6)
- Is RNA-dependent RNA polymerase essential for transposon control? (2011) (6)
- Less Can Be More: RNA-Adapters May Enhance Coding Capacity of Replicators (2012) (6)
- Evolution towards extinction in replicase models: inevitable unless... (2016) (6)
- Multilevel Cellular Automata as a Tool for Studying Bioinformatic Processes (2010) (5)
- Learning What to Eat: Studying Inter-relations Between Learning, Grouping, and Environmental Conditions in an Artificial World (2004) (5)
- Evolution of mutator populations in constant environments (2016) (4)
- 9 – Computing an organism: on the interface between informatic and dynamic processes (2003) (4)
- The consequences of base pair composition biases for regulatory network organization in prokaryotes. (2009) (4)
- Nothing in evolution makes sense except in the light of parasitism: evolution of complex replication strategies (2021) (4)
- The use of time-constrained minimal spanning subtrees in the reconstruction of the phylogeny of the European desmanine moles (Desmaninae, Talpidae, Insectivora) (1989) (4)
- Evolution to Complexity: Replication, Elongation and Assembly in an RNA World (1999) (3)
- Mutational load is ameliorated by increased transcriptional load-associated mutations, if these are biased towards duplications and deletions (2016) (3)
- Reply to the commentaries on “Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life” (2012) (3)
- Nothing in evolution makes sense except in the light of parasites (2021) (3)
- On the potential role of DNA in an RNA world: Pattern generation and information accumulation in replicator systems (1994) (3)
- Evolutionary Conflict Leads to Innovation: Symmetry Breaking in a Spatial Model of RNA-Like Replicators (2017) (3)
- Concomitant immunization by the fully antigenic counterparts prevents modulated tumor cells from escaping cellular immune elimination. (1986) (3)
- Transcriptional Mutagenesis Prevents Ribosomal DNA Deterioration: The Role of Duplications and Deletions (2019) (2)
- Multilevel Evolution: The Fate of Duplicated Genes (2002) (2)
- A social niche breadth score reveals niche range strategies of generalists and specialists. (2023) (2)
- Slightly beneficial genes are retained by evolving Horizontal Gene Transfer despite selfish elements (2020) (2)
- A Cellular Automata Approach to the Modelling of Cell-Cell Interactions (1997) (1)
- On the Degree of Freedom in Multilevel Evolutionary Models (2009) (1)
- Evolution of Complex Regulation for Cell-Cycle Control (2022) (1)
- From bioinformatic pattern analysis to evolutionary dynamics (2002) (1)
- Modelling the evolution of novelty: a review (2022) (1)
- Multilevel Modeling of Morphogenesis (2009) (1)
- Bacteria maintain Slightly Beneficial Genes and Selfish Genetic Elements through the evolution of Horizontal Gene Transfer (2020) (1)
- Modeling complex biological systems: Tackling the parameter curse through evolution (2021) (1)
- COMMENT ON P. LEGENDRE: “A POSTERIORI WEIGHTING OF DESCRIPTORS” (1976) (1)
- Bio-informatics: a working concept. A translation of"Bio-informatica: een werkconcept"by B. Hesper and P. Hogeweg (2021) (1)
- Evolution of evolvability and phenotypic plasticity in virtual cells (2017) (1)
- James A. Shapiro: Evolution: a view from the twenty-first century (2012) (1)
- Social patterns guide evolving grammars (2000) (0)
- Obligate Endosymbiosis Explains Genome Expansion During Eukaryogenesis (2022) (0)
- In silico evo-devo: reconstructing stages in the evolution of animal segmentation (2016) (0)
- Anticipation of a serial transfer protocol through the evolution of fine-tuned growth dynamics (2019) (0)
- Erratum: (Journal of Theoretical Biology (1997) 188 (11-20)) (1997) (0)
- Evolution of Regulatory Complexity for Cell-Cycle Control (2021) (0)
- Around the clock: gradient shape and noise impact the evolution of oscillatory segmentation dynamics (2018) (0)
- Overzichtsartikel From bioinformatic pattern analysis to evolutionary dynamics (2002) (0)
- Evolution of the antigen presentation system and pathogenic evasion (2001) (0)
- Decision letter: Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution (2020) (0)
- KEYNOTE: Biotic systems as multilevel dynamic information processing ssys (2013) (0)
- Evolving Living Technologies - Insights from the EvoEvo Project (2018) (0)
- Correction: Root System Architecture from Coupling Cell Shape to Auxin Transport (2014) (0)
- SUPERBLOCKS AND TESSELATIONS IN CONTINUOUS AND DISCRETE TIMESTEP SIMULATION MODELS (1984) (0)
- Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age (2012) (0)
- Theoretical Biology and Bioinformatics (2009) (0)
- High cost enhances cooperation through the interplay between evolution and self-organisation (2016) (0)
- Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives (2019) (0)
- Contingent evolution of alternative metabolic network topologies determines whether cross-feeding evolves (2020) (0)
- Genome size: neutrality and adaptation (2010) (0)
- On specialists and generalists: niche range strategies across the tree of life (2022) (0)
- Coevolution of gene families in prokaryotes Material Supplemental (2008) (0)
- Non-random random mutations: a signature of evolution of evolution (EVOEVO) (2015) (0)
- James A. Shapiro: Evolution: a view from the twenty-first century (2012) (0)
- The origin of a primordial genome through spontaneous symmetry breaking (2017) (0)
- EvoEvo Deliverable 3.4 (2016) (0)
- The long and winding road to understanding organismal construction: Reply to comments on "From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics". (2022) (0)
- Evolution of mutator populations in constant environments Evolution of mutator populations in constant environments (2022) (0)
- Optimization as Side-Effect of Evolving Allelopathic Diversity (2000) (0)
- 3. Insights from Cellular Automata (2007) (0)
- EvoEvo Deliverable 6.8 (2014) (0)
- Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure (2019) (0)
- Switching from individual-to-collective information processing under high mutation rates (2010) (0)
- Comparative fungal bioinformatics (2003) (0)
- Diet learning and the evolution of cultural inheritance (2008) (0)
- Virtual Microbes evolve multiple mechanisms to the same end: anticipating a serial transfer protocol (2019) (0)
- Mutation Rates and Evolution of Multiple Coding in RNA-based Protocells (2014) (0)
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