Pauline Harrison
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British protein crystallographer
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Pauline Harrisonbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Chemistry Biology
Pauline Harrison's Degrees
- Bachelors Biochemistry University of Oxford
Why Is Pauline Harrison Influential?
(Suggest an Edit or Addition)According to Wikipedia, Pauline May Harrison is a British protein crystallographer and professor emeritus at the University of Sheffield. She gained her chemistry degree from Somerville College, Oxford in 1948, followed by a DPhil in X-ray crystallography in 1952 supervised by Dorothy Hodgkin. After 3 years at King's College London she moved to the University of Sheffield in 1955 as a demonstrator in the Biochemistry department , obtaining an MRC grant to study the iron storage protein Ferritin, publishing preliminary X-ray diffraction data in the 1st volume of the Journal of Molecular Biology in 1959. The molecule which became her life's work. In 1978, she was awarded a personal chair and retired in 1991. In 2001 she was appointed a CBE for services to higher education.
Pauline Harrison's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The ferritins: molecular properties, iron storage function and cellular regulation. (1996) (2449)
- Mineralization in ferritin: an efficient means of iron storage. (1999) (682)
- Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts (1991) (638)
- Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. (1999) (536)
- Ferritin: design and formation of an iron-storage molecule. (1984) (453)
- Structure, function, and evolution of ferritins. (1992) (289)
- Identification of the ferroxidase centre in ferritin (1989) (265)
- Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution. (1997) (265)
- Crystal structure of manganese catalase from Lactobacillus plantarum. (2001) (255)
- Evidence of H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin. (1992) (243)
- Ferritin Mutants of Escherichia coli Are Iron Deficient and Growth Impaired, and fur Mutants are Iron Deficient (1999) (234)
- Electron density map of apoferritin at 2.8-Å resolution (1978) (212)
- The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake. (1972) (195)
- Iron storage in bacteria (1979) (186)
- The prion folding problem. (1997) (146)
- Influence of site-directed modifications on the formation of iron cores in ferritin. (1991) (141)
- The structure of apoferritin: molecular size, shape and symmetry from x-ray data. (1963) (136)
- The high-resolution X-ray crystallographic structure of the ferritin (EcFtnA) of Escherichia coli; comparison with human H ferritin (HuHF) and the structures of the Fe(3+) and Zn(2+) derivatives. (2001) (130)
- Incorporation and release of inorganic phosphate in horse spleen ferritin. (1978) (124)
- On the structure of hemosiderin and its relationship to ferritin. (1971) (121)
- Mössbauer spectroscopic investigation of structure-function relations in ferritins. (1991) (118)
- Evidence that a salt bridge in the light chain contributes to the physical stability difference between heavy and light human ferritins. (1992) (116)
- Reconstituted and native iron-cores of bacterioferritin and ferritin. (1987) (115)
- Three-dimensional structure of the enzyme dimanganese catalase from Thermus Thermophilus at 1 Å resolution (2000) (114)
- Defining the roles of the threefold channels in iron uptake, iron oxidation and iron-core formation in ferritin: a study aided by site-directed mutagenesis. (1993) (112)
- Effect of ferritin-containing fractions with different iron loading on lipid peroxidation. (1983) (104)
- The disulphide beta-cross: from cystine geometry and clustering to classification of small disulphide-rich protein folds. (1996) (101)
- Ferritin iron uptake and release. Structure-function relationships. (1974) (99)
- Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of Escherichia coli K-12 (1989) (99)
- The structures of ferritin and apoferritin: Some preliminary X-ray data* (1959) (97)
- Probing Structure-Function Relations In Ferritin And Bacterioferritin (1991) (97)
- Structure and composition of ferritin cores from pea seed (Pisum sativum). (1993) (92)
- Thermodynamics of model prions and its implications for the problem of prion protein folding. (1999) (87)
- Ferritin: molecular structure and iron-storage mechanisms. (1980) (87)
- Conformational propagation with prion‐like characteristics in a simple model of protein folding (2001) (86)
- Amino-acid sequence and predicted three-dimensional structure of pea seed (Pisum sativum) ferritin. (1992) (86)
- Site-directed Replacement of the Coaxial Heme Ligands of Bacterioferritin Generates Heme-free Variants (*) (1995) (83)
- The structure of apoferritin: degradation into and molecular weight of subunits. (1963) (80)
- Overproduction, purification and characterization of the Escherichia coli ferritin. (1993) (79)
- How the presence of three iron binding sites affects the iron storage function of the ferritin (EcFtnA) of Escherichia coli (1998) (77)
- The three-dimensional structure of the di-Mn catalase and the environment of the di-Mn sites in different redox states (1997) (74)
- The formation of ferritin from apoferritin. Inhibition and metal ion-binding studies. (1973) (72)
- Identification of the ferroxidase centre of Escherichia coli bacterioferritin. (1995) (72)
- cDNA cloning and deduced amino acid sequence of two ferritins: soma ferritin and yolk ferritin, from the snail Lymnaea stagnalis L. (1994) (70)
- Analysis and classification of disulphide connectivity in proteins. The entropic effect of cross-linkage. (1994) (70)
- Overproduction, purification and characterization of the bacterioferritin of Escherichia coli and a C-terminally extended variant. (1993) (69)
- Iron (II) oxidation and early intermediates of iron-core formation in recombinant human H-chain ferritin. (1993) (68)
- Iron(II) oxidation by H chain ferritin: evidence from site-directed mutagenesis that a transient blue species is formed at the dinuclear iron center. (1995) (68)
- Mössbauer spectroscopic study of the initial stages of iron-core formation in horse spleen apoferritin: evidence for both isolated Fe(III) atoms and oxo-bridged Fe(III) dimers as early intermediates. (1989) (65)
- Metals in Biochemistry (1980) (64)
- Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites. (1997) (63)
- The formation of ferritin from apoferritin. Catalytic action of apoferritin. (1973) (59)
- A note on the composition and properties of ferritin iron cores. (1987) (58)
- Electron-microscopic and chemical studies of oligomers in horse ferritin. (1968) (58)
- Structure of horse-spleen apoferritin at 6 Å resolution (1975) (56)
- Self-assembly of apoferritin from horse spleen after reversible chemical modification with 2,3-dimethylmaleic anhydride. (1988) (56)
- Bacterioferritins and ferritins are distantly related in evolution Conservation of ferroxidase‐centre residues (1991) (55)
- Spectroscopic studies on the binding of iron, terbium, and zinc by apoferritin. (1984) (52)
- Recombinant H‐chain ferritins: Effects of changes in the 3‐fold channels (1989) (52)
- Structure-function relationships in the ferritins. (1998) (51)
- The structure and function of ferritin. (1976) (50)
- Ferritin Structure and Function (1984) (50)
- Ferritin as an iron-storage protein: mechanisms of iron uptake. (1986) (49)
- Ferritin: an iron-storage molecule. (1977) (49)
- The structural relationship between ferritin protein and its mineral core. (1969) (48)
- Effects of modifications near the 2-, 3- and 4-fold symmetry axes on human ferritin renaturation. (1997) (46)
- Helix packing and subunit conformation in horse spleen apoferritin (1980) (46)
- Siderosomal ferritin. The missing link between ferritin and haemosiderin? (1987) (41)
- Evidence for the existence of stable "aggregates" in horse ferritin and apoferritin. (1965) (40)
- The structure of apoferritin: amino acid composition and end-groups. (1962) (39)
- Proteins of iron metabolism (1979) (39)
- Release of iron from ferritin molecules and their iron-cores by 3-hydroxypyridinone chelators in vitro. (1989) (37)
- Haem and non-haem iron sites in Escherichia coli bacterioferritin: spectroscopic and model building studies. (1993) (37)
- Heterogeneity in horse ferritins. A comparative study of surface charge, iron content and kinetics of iron uptake. (1978) (37)
- A computer-assisted method for determining the nearest integer ratios of amino acid residues in purified proteins. (2009) (37)
- The binding of ferric iron by ferritin. (1979) (34)
- Amino acid sequence of the bacterioferritin (gytochrome b1) of Escherichia coli-K12 (1989) (34)
- An X-ray scattering study of the bacterial virus R17 (1965) (33)
- Ferritin and haemosiderin (1964) (32)
- The structure of apoferritin: evidence for chemical subunits from "fingerprints" of tryptic digests. (1962) (32)
- Molecular size and symmetry of the bacterioferritin of Escherichia coli. X-ray crystallographic characterization of four crystal forms. (1989) (31)
- Tyrosyl radical formation during the oxidative deposition of iron in human apoferritin. (1995) (31)
- Structural and functional studies on ferritins. (1987) (30)
- Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto. (1997) (30)
- Uptake and release of ferritin iron. Surface effects and exchange within the crystalline core. (1974) (29)
- A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map. (1991) (29)
- Insights into the Effects on Metal Binding of the Systematic Substitution of Five Key Glutamate Ligands in the Ferritin of Escherichia coli* (2003) (29)
- The identity of Escherichia coli bacterioferritin and cytochrome b1. (1988) (27)
- Studies on haemosiderin and ferritin from iron-loaded rat liver (2005) (26)
- Physical, chemical and immunological properties of the bacterioferritins of Escherichia coli, Pseudomonas aeruginosa and Azotobacter vinelandii. (1991) (25)
- Catalytic iron(II) oxidation in the non-haem ferritin of Escherichia coli: the early intermediate is not an iron tyrosinate* (1997) (25)
- The amino acid sequence of human liver apoferritin (1983) (25)
- Stages in iron storage in the ferritin of Escherichia coli (EcFtnA): analysis of Mössbauer spectra reveals a new intermediate. (1999) (24)
- The release of iron from horse spleen ferritin to 1,10-phenanthroline. (1974) (24)
- The relationship between ferritin and haemosiderin (1986) (23)
- The classification of helium-rich hot subdwarfs (1997) (23)
- The spatial structure of horse spleen apoferritin (1983) (20)
- A new form of ferritin heterogeneity explained. Isolation and identification of a nineteen-amino-acid-residue fragment from siderosomal ferritin of rat liver. (1987) (20)
- The use of zinc(II) to probe iron binding and oxidation by the ferritin (EcFtnA) of Escherichia coli (1998) (18)
- Metal proteins with non-redox roles (1985) (18)
- Iron-induced changes in rat liver isoferritins. (1984) (17)
- Artifacts in ferritin isoelectric focussing profiles (1979) (17)
- Metal binding at the active centre of the ferritin of Escherichia coli (EcFtnA). A Mössbauer spectroscopic study (2000) (17)
- Interaction of aluminium citrate with horse spleen ferritin. (1992) (16)
- Evidence for post-translational changes in rat liver ferritin. (1980) (14)
- Ferritin, the path of iron into the core, as seen by Mössbauer spectroscopy (2003) (12)
- Genetic and structural characterization of the bacterioferritin of Escherichia coli. (1990) (12)
- Biochemistry of iron. (1971) (12)
- Proximity effects in pyridines. Proton chemical shifts in substituted methyl pyridinecarboxylates (1975) (12)
- Expression and purification of the rat liver ferritin light chain after cloning in Escherichia coli (1988) (12)
- A molecular model for the quaternary structure of ferritin (1988) (12)
- Lability of iron at the dinuclear centres of ferritin studied by competition with four chelators (1996) (12)
- Very-low-resolution structure of a bacterioferritin (1988) (11)
- The location of exon boundaries in the multimeric iron-storage protein ferritin (2005) (11)
- Ferritin does not accumulate iron oxidized by caeruloplasmin. (1995) (10)
- Composition and dynamics of iron in iron-poor ferritin (1988) (10)
- Inhibition by Zinc Ions of Ferritin Formation in vitro (1973) (9)
- Infrared spectroscopy as a measure of proximity effects—ortho-substituted benzonitriles and alpha-substituted ortho toluonitriles (1975) (9)
- Structural homology between mouse liver and horse spleen ferritins (1985) (8)
- Quaternary structure of apoferritin: the rotation function at 9 A resolution. (1974) (8)
- Expression in Escherichia coli of a secreted invertebrate ferritin. (1994) (8)
- Mechanism of Fe(II) oxidation and core formation in ferritin. (1994) (8)
- Spectroscopic identification of the haem axial ligands of haemoferritin and location of possible haem-binding sites in ferritin by molecular modelling. (1992) (8)
- Frequency and intensity measurements of the carbonyl stretching vibration in substituted methyl benzoates and pyridine carboxylates (1975) (8)
- Optically active co-ordination compounds. Part IX. Complexes of dipeptides with cobalt(III) (1967) (7)
- Non-random distribution of iron entering rat liver ferritin in vivo. (1984) (6)
- Structural studies on recombinant human ferritins. (1990) (6)
- Optically active co-ordination compounds. Part XII. Some mixed complexes of L-amino-acids and ethylenediamine with cobalt(III) (1967) (6)
- Lysosomal and cytosolic ferritins A biochemical and electron-spectroscopic study (2005) (6)
- Immunochemistry of extracts from Leptospira interrogans serotype hardjo. (1977) (6)
- A tetragonal crystal form of horse spleen apoferritin and its relationship to the cubic modification. (1974) (5)
- First-order phase transition in protein dynamics of ferritin (1987) (5)
- Preparation, characterization and storage of human ferritin for use as a standard for the assay of serum ferritin (2008) (5)
- Structure of horse-spleen apoferritin at 6 angstom resolution. (1975) (5)
- Amino acid sequence of the bacterioferritin (cytochrome b1) of Escherichia coli-K12. (1989) (5)
- Ferritin: A Model System for Iron Biomineralization (1991) (5)
- Metal-ion-binding sites and the role of the iron-core in iron(II) uptake by ferritin. (1980) (5)
- The structure and heavy-metal-ion-binding sites of horse spleen apoferritin. (1980) (4)
- The functional role of isoferritins. (1980) (4)
- Serological and chemical interrelationship of antigens from Leptospira interrogans serovar canicola. (1980) (3)
- Studies on the subcellular processing of iron dextran by rat liver (1988) (3)
- THE FERRITIN MOLECULE: A SIMK AND A SOURCE FOR IRON (1978) (2)
- CRYSTAL STRUCTURE OF THE E.COLI FERRITIN ECFTNA (2001) (2)
- A spectral analysis of the hydrogen-deficient star HD144941 (1997) (2)
- Iron transfer between ferritin molecules (1992) (2)
- Dramatic increase in ferritin crystal lifetime with monochromatic synchrotron X-radiation tuned to a wavelength above the iron K absorption edge (1989) (2)
- Iron(III) species formed during iron(II) oxidation and iron-core formation in the bacterioferritin of Escherichia coli (1996) (2)
- The prion folding problem . Review article (1998) (2)
- Functional studies on rat-liver isoferrints (1984) (2)
- The function of H and L chains in iron sequestration in ferritin (1993) (2)
- Bacterioferritin: A Microbial Iron-Storage Protein? (1991) (1)
- Storage and transport of transition-metal ions (1979) (1)
- Metal proteins with redox roles (1985) (1)
- Electron transfer and redox reactions (1980) (1)
- The preparative separation of horse and human ferritins by chromatofocusing. (1984) (1)
- The role of the dinuclear centers in iron storage in the ferritins (2008) (1)
- Ferritin subunits in livers of siderotic mice (2005) (1)
- Analysis and prediction of protein structure : disulphide bridges. (1996) (1)
- Spectral analysis of the low-gravity extreme helium stars LSS 4357, LS II+33.5 deg and LSS 99 (1998) (1)
- Computational Chemistry Methods in Structural Biology (2001) (1)
- Solid model representations of a multimeric protein. (1989) (1)
- Dealing with oxygen (1980) (1)
- simple model of protein folding Conformational propagation with prion-like characteristics in a (2000) (0)
- THE IRON ABUNDANCE IN HELIUM STAR HD 144941 (1997) (0)
- Non-haem iron centres of bacterioferritin by EPR spectroscopy (1991) (0)
- X-ray crystallographic analysis of horse spleen apoferritin (1981) (0)
- Crystal Structure of Manganese Catalase from Lactobacillus plantarum complexed with azide (2002) (0)
- Erratum to: Bacterioferritin: A Microbial Iron-Storage Protein? (1991) (0)
- Functional studies on rat-liver isoferritins. (1984) (0)
- Inter-subunit interactions and metal binding sites in horse spleen apoferritin (1981) (0)
- Understanding ferritin function with the help of Escherichia.coli: Mossbauer spectroscopic and structural studies of recombinant ferritins (1991) (0)
- An EPR investigation of E. Coli bacterioferritin (1993) (0)
- Metals and metabolism: By D. A. Phipps. Pp. 134. Oxford Chemistry Series, No. 26. Clarendon Press: Oxford University Press, 1976. Paper £2.50, boards £5.00 (1977) (0)
- The essential metals and their evolution (1980) (0)
- HUMAN H CHAIN FERRITIN (1997) (0)
- ImprovedAssay for Bismuthin BiologicalSamples by AtomicAbsorptionSpectrophotometry with HydrideGeneration (2004) (0)
- The haem binding site in the bacterioferritin of Escherichia coli (1991) (0)
- A&a Manuscript No (2007) (0)
- Book Review:Inorganic Biochemistry of Iron Metabolism. Robert R. Crichton (1993) (0)
- The non-redox roles of metals ions (1980) (0)
- Crystal structure of Mn catalase from Thermus Thermophilus complexed with chloride (2007) (0)
- of changes in the 3-fold (1989) (0)
- Dynamics of Iron in Ferritin (1987) (0)
- Structure of the iron storage protein ferritin using synchrotron data (1984) (0)
- THE RELATIONSHIP BETWEEN FERRITIN A N D (0)
- Atomic resolution structure of Mn catalase from Thermus Thermophilus (2007) (0)
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