Per Artursson
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Per Arturssonbiology Degrees
Biology
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Biotechnology
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Computational Biology
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Molecular Biology
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Biology
Per Artursson's Degrees
- Masters Biotechnology Uppsala University
- Bachelors Molecular Biology Uppsala University
Why Is Per Artursson Influential?
(Suggest an Edit or Addition)Per Artursson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. (1991) (1686)
- Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers (2007) (1000)
- Caco-2 monolayers in experimental and theoretical predictions of drug transport. (2001) (940)
- Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. (1990) (831)
- Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1 (2001) (765)
- Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) (1994) (683)
- Caco-2 monolayers in experimental and theoretical predictions of drug transport (1996) (560)
- Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines (2007) (550)
- Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement (1997) (540)
- Coexistence of passive and carrier-mediated processes in drug transport (2010) (525)
- Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo (2001) (492)
- Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. (2001) (452)
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (2014) (405)
- Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers (2004) (371)
- Correlation of drug absorption with molecular surface properties. (1996) (351)
- Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. (2006) (346)
- Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) Cells (1996) (332)
- Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. (1998) (312)
- Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs (2009) (299)
- Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions (2012) (294)
- Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement. (1999) (294)
- Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues. (2016) (293)
- Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium. (2005) (281)
- Expression of specific markers and particle transport in a new human intestinal M-cell model. (2000) (258)
- Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond (1997) (257)
- Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo (1996) (251)
- Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. (2008) (248)
- Cell cultures as models for drug absorption across the intestinal mucosa. (1991) (245)
- Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments (1993) (238)
- Experimental and computational screening models for the prediction of intestinal drug absorption. (2001) (235)
- Absorption classification of oral drugs based on molecular surface properties. (2003) (233)
- Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier (1990) (227)
- Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. (1990) (226)
- Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs. (2014) (225)
- Epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. (1992) (216)
- Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells (2001) (209)
- pH-Dependent Bidirectional Transport of Weakly Basic Drugs Across Caco-2 Monolayers: Implications for Drug–Drug Interactions (2003) (195)
- Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo (2003) (195)
- Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. (1995) (187)
- Diffusion of drugs in native and purified gastrointestinal mucus. (1997) (186)
- Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein (1993) (184)
- Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors. (1998) (183)
- Mechanisms of absorption enhancement and tight junction regulation (1994) (182)
- Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. (2008) (177)
- Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. (2010) (176)
- Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs. (1999) (176)
- Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method (2005) (172)
- PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS (2006) (167)
- Accuracy of calculated pH-dependent aqueous drug solubility. (2004) (165)
- Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability (2003) (164)
- A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial caco 2 cells grown in permeable filter chambers (1991) (163)
- Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route (1993) (161)
- Economics of the Family (2014) (160)
- Experimental and Computational Screening Models for Prediction of Aqueous Drug Solubility (2002) (158)
- Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. (1993) (154)
- Rapid measurement of intracellular unbound drug concentrations. (2013) (144)
- Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models. (2010) (142)
- pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers. (2005) (141)
- Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11) (2013) (140)
- Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption (1995) (139)
- The Influence of Intestinal Mucus Components on the Diffusion of Drugs (2004) (134)
- Efflux transporters in ulcerative colitis: Decreased expression of BCRP (ABCG2) and Pgp (ABCB1) (2007) (132)
- Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). (2008) (130)
- Applications of epithelial cell culture in studies of drug transport. (2002) (130)
- In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes. (2016) (124)
- Exploring the role of different drug transport routes in permeability screening. (2005) (123)
- Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation (2018) (120)
- Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs (2009) (120)
- A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2) (2007) (120)
- Chitosan and the mucosal delivery of biotechnology drugs. (2005) (117)
- A new principle for tight junction modulation based on occludin peptides. (2003) (116)
- Characterization of polyacryl starch microparticles as carriers for proteins and drugs. (1984) (115)
- CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil (2016) (114)
- Structural and conformational determinants of macrocycle cell permeability. (2016) (113)
- Microparticles as potentially orally active immunological adjuvants. (1989) (113)
- Preparation of Biodegradable Microparticles Using Solution-Enhanced Dispersion by Supercritical Fluids (SEDS) (1999) (112)
- Virtual screening of intestinal drug permeability. (2000) (111)
- In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions (2011) (110)
- Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber. (1998) (109)
- Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions (2014) (109)
- Prediction of the Oral Absorption of Low-Permeability Drugs Using Small Intestine-Like 2/4/A1 Cell Monolayers (2003) (106)
- Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. (2012) (105)
- Validation and development of MTH1 inhibitors for treatment of cancer. (2016) (103)
- Contribution of solid-state properties to the aqueous solubility of drugs. (2006) (103)
- PEI – a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in mice (2003) (99)
- Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. (2006) (98)
- Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. (2014) (98)
- Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure. (2015) (95)
- Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes. (2017) (92)
- A conditionally immortalized epithelial cell line for studies of intestinal drug transport. (1999) (91)
- Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate (1997) (90)
- Genetic variation in the ATP-binding cassette transporter gene ABCG2 (BCRP) in a Swedish population. (2003) (90)
- A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids. (2000) (90)
- RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (2014) (89)
- Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. (1999) (89)
- Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics. (1999) (89)
- A Drug Absorption Model Based on the Mucus Layer Producing Human Intestinal Goblet Cell Line HT29-H (1993) (85)
- Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method. (2005) (84)
- Molecular characteristics for solid-state limited solubility. (2008) (83)
- Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs (2003) (82)
- CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies. (2001) (82)
- Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches (2006) (81)
- Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes. (1998) (80)
- Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions. (1995) (80)
- Global and Local Computational Models for Aqueous Solubility Prediction of Drug-Like Molecules (2004) (79)
- Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties. (2008) (79)
- Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity. (2004) (78)
- Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions (2011) (75)
- Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum (2006) (75)
- Preparation and characterisation of chitosans with oligosaccharide branches. (2002) (73)
- Preparation and evaluation of sterically stabilized liposomes: colloidal stability, serum stability, macrophage uptake, and toxicity. (1990) (70)
- Theoretical Calculation and Prediction of Caco-2 Cell Permeability Using MolSurf Parametrization and PLS Statistics (1997) (70)
- The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells (1993) (68)
- Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper (2019) (68)
- Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery (2017) (67)
- Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties (2014) (67)
- A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer. (1992) (66)
- Theoretical Predictions of Drug Absorption in Drug Discovery and Development (2002) (61)
- Gene Expression Profiles in Mouse Lung Tissue after Administration of Two Cationic Polymers Used for Nonviral Gene Delivery (2006) (60)
- The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition. (2016) (60)
- Prediction of Membrane Permeability to Peptides from Calculated Dynamic Molecular Surface Properties (1999) (60)
- Intracellular drug bioavailability: a new predictor of system dependent drug disposition (2017) (59)
- Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. (2021) (59)
- Impact of Extracellular Protein Binding on Passive and Active Drug Transport Across Caco-2 Cells (2005) (58)
- Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers (1999) (55)
- Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring (2004) (54)
- Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity (1999) (54)
- An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport: Characterization of Transport Routes (2003) (53)
- A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation (2017) (53)
- Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis (2008) (53)
- Biodegradable microspheres. V: Stimulation of macrophages with microparticles made of various polysaccharides. (1987) (53)
- Biodegradable microspheres. IV: Factors affecting the distribution and degradation of polyacryl starch microparticles. (1986) (51)
- Absorption of a vasopressin analogue, 1-deamino-8-d-arginine-vasopressin (dDAVP), in a human intestinal epithelial cell line, CaCO-2 (1990) (51)
- A modified physiological BCS for prediction of intestinal absorption in drug discovery. (2010) (50)
- Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs. (2004) (49)
- Lipidic conjugates of luteinizing hormone releasing hormone (LHRH)+ and thyrotropin releasing hormone (TRH)+ that release and protect the native hormones in homogenates of human intestinal epithelial (Caco-2) cells (1994) (49)
- Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres. (1999) (47)
- Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach (2016) (47)
- Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability (2016) (44)
- Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9. (2016) (43)
- Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice. (2013) (41)
- In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation. (2010) (39)
- The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox. (2013) (38)
- Novel lipoamino acid- and liposaccharide-based system for peptide delivery: application for oral administration of tumor-selective somatostatin analogues. (1999) (37)
- A miniaturized nebulization catheter for improved gene delivery to the mouse lung (2005) (36)
- Quantifying the impact of transporters on cellular drug permeability. (2015) (36)
- Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity. (2016) (36)
- Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. (2016) (33)
- Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties (2015) (32)
- Biodegradable microspheres. III: some immunological properties of polyacryl starch microparticles. (1986) (32)
- Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers (1996) (31)
- A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain (2014) (31)
- The Critical Role of Passive Permeability in Designing Successful Drugs (2020) (31)
- A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies. (2017) (31)
- Biodegradable microspheres. I. Duration of action of dextranase entrapped in polyacrylstarch microparticles in vivo. (1984) (31)
- Biopharmaceutics of Microparticulate Drug Carriers (1987) (31)
- The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers. (2018) (30)
- Comparison of CYP3A Activities in a Subclone of Caco-2 Cells (TC7) and Human Intestine (1997) (29)
- Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking. (2018) (27)
- Direct Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates (2018) (27)
- Characterization of surface-modified nanoparticles for in vivo biointeraction. A sedimentation field flow fractionation study. (2005) (26)
- Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids. (2018) (24)
- Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions. (2016) (24)
- A Novel Approach for Prediction of Intestinal Absorption of Drugs in Humans based on Hydrogen Bond Descriptors and Structural Similarity (2001) (24)
- Substrate and method dependent inhibition of three ABC‐transporters (MDR1, BCRP, and MRP2) (2017) (24)
- A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity (2019) (23)
- Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures. (2016) (23)
- CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box (2018) (22)
- Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers. (2003) (22)
- Macrophage Stimulation with Some Structurally Related Polysaccharides (1987) (22)
- Cell‐type‐resolved proteomic analysis of the human liver (2020) (21)
- Studies of membrane permeability and oral absorption 6: Caco-2 and emerging alternatives for prediction of intestinal drug transport: A general overview. (2004) (21)
- Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein (2005) (21)
- Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1) (1996) (21)
- Effects of a new lipid-based drug delivery system on the absorption of low molecular weight heparin (Fragmin) through monolayers of human intestinal epithelial Caco-2 cells and after rectal administration to rabbits (1994) (21)
- An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux. (2013) (20)
- Determination of the degree of derivatization of acryloylated polysaccharides by Fourier transform proton NMR spectroscopy. (1983) (20)
- Breaking the intestinal barrier to deliver drugs (2015) (20)
- Intestinal tissue distribution and epithelial transport of the oral immunogen LTB, the B subunit of E. coli heat-labile enterotoxin. (1993) (20)
- A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes (2019) (19)
- Global variability analysis of mRNA and protein concentrations across and within human tissues (2019) (19)
- Receptor-mediated uptake of starch and mannan microparticles by macrophages: relative contribution of receptors for complement, immunoglobulins and carbohydrates. (1988) (18)
- Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues. (2002) (18)
- Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs. (2003) (18)
- Biodegradable microspheres II: Immune response to a heterologous and an autologous protein entrapped in polyacryl starch microparticles. (1985) (18)
- Toxicological and absorption enhancing effects of glycofurol 75 and sodium glycocholate in monolayers of human intestinal epithelial (Caco-2) cells (1993) (18)
- Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket. (2014) (18)
- Effect of opsonins on the macrophage uptake of polyacrylstarch microparticles (1986) (18)
- Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (17)
- Oral absorption of lipidic amino acid conjugates (1994) (17)
- Tetanus antigen modulates the gene expression profile of aluminum phosphate adjuvant in spleen lymphocytes in vivo (2002) (16)
- Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy (2020) (16)
- Passive permeability and active transport models for the prediction of oral absorption (2007) (16)
- Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. (2013) (16)
- Gene expression after vaccination of mice with formulations of diphtheria toxoid or tetanus toxoid and different adjuvants: identification of shared and vaccine-specific genes in spleen lymphocytes. (2003) (15)
- Biodegradable microspheres. VIII: Killing of Leishmania donovani in cultured macrophages by microparticle-bound primaquine (1987) (15)
- Intestinal Absorption: The Role of Polar Surface Area (2004) (15)
- The Contribution of Intestinal Secretion to the Dose-Dependent Absorption of Celiprolol (1994) (14)
- Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor. (2013) (14)
- An Overview of Caco‐2 and Alternatives for Prediction of Intestinal Drug Transport and Absorption (2008) (14)
- Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1 (2013) (14)
- Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. (2017) (13)
- Magnetic starch microspheres: Interactions of a microsphere MR contrast medium with macrophages in vitro (1990) (13)
- Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations (2019) (13)
- Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2-P1' Region. (2014) (12)
- Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells. (1996) (12)
- Studying transport in absorptive epithelia (1996) (12)
- Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight (2020) (11)
- Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies (2019) (11)
- Preparation of sterically stabilized nanoparticles by desolvation from graft copolymers (1990) (11)
- Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. (2014) (11)
- Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells. (2009) (11)
- Expression of 36 drug transporter genes in human intestine, liver, kidney, and organotypic cell lines (2007) (10)
- Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat (2013) (10)
- Passive Absorption of Drugs in Caco-2 Cells (1991) (10)
- Immobilized L-asparaginase-L-glutaminase from Acinetobacter glutaminasificans in microspheres: some properties in vivo and in an extracorporeal system (1987) (9)
- Acrylic microspheres in vivo. X. Elimination of circulating cells by active targeting using specific monoclonal antibodies bound to microparticles. (1986) (9)
- Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound (2018) (9)
- Orally Active Antiviral Tripeptide Glycyl-Prolyl-Glycinamide Is Activated by CD26 (Dipeptidyl Peptidase IV) before Transport across the Intestinal Epithelium (2005) (9)
- Absorption of thyrotropin-releasing hormone (TRH) and a TRH prodrug in a human intestinal cell line (Caco-2) (1991) (9)
- Computational Prospecting for Drug–Transporter Interactions (2013) (8)
- Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (2017) (8)
- Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors (2011) (8)
- Inflammatory response to polyacryl starch microparticles, role of arachidonic acid metabolites (1988) (8)
- Quantification and Imaging of Mannitol Transport Through Caco-2 Cell Monolayers Using a Positron-Emitting Tracer (1998) (8)
- Chitosans of absorption enhancers of poorly absorbable drugs: Influence of molecular weight and degree of acetylation (1996) (8)
- Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. (2015) (7)
- Cellular and biochemical interactions of macromolecular drug delivery systems (1989) (7)
- Biochemical and cellular effects of degraded starch microspheres on macrophages (1989) (6)
- The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells. (2016) (6)
- High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 (2022) (6)
- Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions (2020) (6)
- Cell cultures as models for intestinal peptide transport (1993) (6)
- Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. (2021) (6)
- Expanding the efflux in vitro assay toolbox: A CRISPR-Cas9 edited MDCK cell line with human BCRP and completely lacking canine MDR1. (2020) (6)
- In Vitro Characterization of Interactions with Drug Transporting Proteins (2013) (6)
- Addendum to 'Quantifying the impact of transporters on cellular drug permeability'. (2015) (6)
- Relative contribution of phosphatidylcholine and monoglyceride to absorption enhancement of low molecular weight heparin (Fragmin) by a new lipid-based drug delivery system in monolayers of human intestinal epithelial Caco-2 cells and after rectal administration to rabbits (1994) (6)
- Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells (2018) (6)
- Image-Based Quantification of Cell Debris as a Measure of Apoptosis. (2019) (5)
- Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial (2021) (5)
- Proteomics-informed identification of luminal targets for in situ diagnosis of inflammatory bowel disease. (2020) (5)
- Conditionally Immortalized Intestinal Epithelial Cells: A New Model for Studying Intestinal Epithelial Cell Turnover (1998) (4)
- A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell) (2019) (4)
- Conditions for maintenance of hepatocyte differentiation and function in 3D cultures (2021) (4)
- Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity (2022) (4)
- A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man. (2016) (4)
- Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis (2021) (4)
- Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity (2022) (4)
- Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (2017) (4)
- Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase) (2016) (4)
- Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range (2022) (3)
- Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles. (2014) (3)
- Starch microspheres enhance insulin absorption across epithelial cells by affecting the integrity of tight junctions (1992) (3)
- A new approach to chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers (2003) (3)
- Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers (2007) (3)
- Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity (2022) (3)
- Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat (2022) (3)
- Regulation of immediate and long term effects of the absorption enhancer sodium caprate in human intestinal epithelial (Caco-2) cells (1996) (3)
- A new opening for orally taken peptide drugs (2020) (3)
- Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1. (2007) (3)
- Development of in vitro M-cell model for macromolecule transport (2004) (3)
- X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol (2005) (2)
- Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases (2016) (2)
- Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1) (2010) (2)
- Increased CD9 and β1-integrin expression in human follicle associated epithelium is linked with selective transport into human Peyer´s patches (2005) (2)
- Experimental and Theoretical Predictions of Intestinal Drug Absorption (2007) (2)
- The Need for Speed-Kinetic Limits of Drug Transporters. (2016) (2)
- Cell cultures to assess drug transport and metabolism - Preface (1996) (2)
- Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison (2016) (2)
- Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer (2021) (2)
- Microspheres as drug carriers : some consequences of the delivery of microparticles to the reticuloendothelial system (1985) (2)
- The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients. (2022) (1)
- To attach or not to attach : factors behind variable adhesion properties of cryopreserved human hepatocytes (2016) (1)
- Getting a grip with kirigami (2021) (1)
- Comparative proteomics of human liver tissue and hepatocytes reveal systematic differences in proteins determining hepatic drug exposure (2015) (1)
- Hepatocyte size fractionation allows dissection of human liver zonation (2021) (1)
- LogP-Independent Solubility of Drugs - Molecular Descriptors for Solid-State Limited Solubility (2006) (1)
- An alternative explanation for low membrane permeability of highly lipophilic drugs (1996) (1)
- Uptake mechanism of ochratoxin A and citrinin through human liver (2010) (1)
- Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation (2022) (1)
- Comparison and Prediction of Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 (2007) (1)
- Experimental and theoretical predictions of intestinal drug absorption, in Computer-assisted lead finding and optimization (1997) (1)
- Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ (2021) (1)
- Cell Culture Absorption Models – State of the Art (2006) (1)
- Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogs (2000) (1)
- Biliary Drug Excretion and Drug-drug Interactions in Sandwich Cultured Human Hepatocytes Predicted from Inverted Membrane Vesicles and Targeted Proteomics (2013) (0)
- A new approach to absorption enhancement based on the molecular structure of occludin (2000) (0)
- IL06 Cell cultures in experimental and theoretical predictions of oral drug absorption (1996) (0)
- P48 Prediction of intestinal drug absorption from molecular surface properties (1994) (0)
- Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies (2019) (0)
- Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines. (2017) (0)
- Mechanistic modeling of hepatic pitavastatin disposition : a proteomics-informed bottom-up approach (2016) (0)
- Influence of nanoparticle properties on their transport through an optimized Human intestine Follicle Associated Epithelium model (2004) (0)
- S-01-02 In vitro ADME assays to inform IVIVE-PBK modelling and simulation (2022) (0)
- A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell) (2019) (0)
- Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance (2016) (0)
- Effect of cell penetrating peptides on GLP-1R-mediated intracellular delivery of antisense oligonucleotides (2018) (0)
- Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1) (2010) (0)
- Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis (2021) (0)
- Chitosan oligomers as siRNA delivery systems in vitro (2006) (0)
- FC29 permeability of drugs with different physico-chemical properties in the human jejunum and Caco-2 monolayers (1994) (0)
- mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells (2012) (0)
- Polymere de chitosane a taux d'acetylation specifique (1995) (0)
- Differential expression of ABC transporters in colonic and rectal mucosa during active and inactive phases of ulcerative colitis (2005) (0)
- Proteomic analysis of major cell types in the human liver (2019) (0)
- Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations (2019) (0)
- A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes (2018) (0)
- The influence of gastrointestinal mucos and mucin on drug diffusion (1996) (0)
- In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions (2011) (0)
- P49 Paracellular absorption enhancement in intestinal CACO-2 monolayers by sodium caprate (1994) (0)
- Drug-induced gene regulation and function of ABC-transporters in human intestinal epithelial cell lines (2003) (0)
- Impact of intracellular bioavailability on metabolic drug-drug interactions (2018) (0)
- Erratum to “Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1)” [Int. J. Pharm. 138 (1996) 167]1 (1996) (0)
- Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration. (2021) (0)
- Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat (2013) (0)
- HT29-MTX細胞を基にした新規粘液-分泌細胞培養モデルでの親油性薬物分子の輸送 (2001) (0)
- Erratum: Structural and conformational determinants of macrocycle cell permeability. (2017) (0)
- Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver (2019) (0)
- Professor Margareta Hammarlund-Udenaes - A Humble Scientist Shaping Modern Neuropharmacokinetics (2022) (0)
- Determination of the transport across CACO-2 cell monolayers of compounds varying in lipophilicity using LC-MS (2000) (0)
- Impact of intracellular drug bioavailability on cellular drug response (2016) (0)
- Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol (2016) (0)
- Proteomics-informed prediction of rosuvastatin clearance in donors with and without obesity (2019) (0)
- Global expression variability of proteins across and within human tissues (2019) (0)
- A new opening for orally taken peptide drugs (2020) (0)
- Apoptosis Detection by Quantification of Cell Debris in Bright-Field Microscopy Images. (2022) (0)
- Structure-function relationship in chitosan-mediated gene delivery: controlling polyplex disassembly through chitosan design. (2009) (0)
- Impact of drug transporters on intracellular drug concentrations (2016) (0)
- Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist. (2017) (0)
- GLOBAL MEMBRANE PROTEIN ANALYSIS OF THE HUMAN LIVER: APPLICATION IN PREDICTIONS OF ATORVASTATIN UPTAKE CLEARANCE (2015) (0)
- Impact of extracellular protein binding on active drug transport across Caco-2 cells (2005) (0)
- A cell free approach for determination of cell specific drug binding based on phospholipid speciation (2018) (0)
- Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells (2018) (0)
- Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1 (2019) (0)
- Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (0)
- Experimental approaches to understand intracellular based drug bioavailability (2019) (0)
- 182. Branched Chitosan Oligomers Enhance Gene Delivery In Vitro and after Lung Administration In Vivo (2006) (0)
- New cell-based approaches for better predictions of drug transport and cellular drug exposure (2016) (0)
- TNF-α, TGF-β, and LTα1/β2 induces particle uptake and augments B-cell-induced particle transcytosis in intestinal epithelial cells (2005) (0)
- Development of MS- based immunoassays for Cytochrome P450 and transporter quantification (2016) (0)
- Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ (2019) (0)
- Meet Our Editorial Board Member (2020) (0)
- Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte (2010) (0)
- Epithelial and microbial determinants of colonic drug distribution. (2023) (0)
- Oligosaccharide branched chitosan oligomers as gene delivery systems in vitro and after lung administration in vivo (2003) (0)
- Impact of drug transporters on intracellular unbound drug concentrations (2016) (0)
- University of Southern Denmark Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties Implications for Renal Acamprosate Secretion and Drug-Drug Interactions (2020) (0)
- The enteropathogen Yersinia pseudotuberculosis induces transcytosis across the human intestinal epithelium (2005) (0)
- Correlations between intestinal permeability profiles of polyethylene glycols of different molecular weights in humans, rats and in a human intestinal epithelial cell line (1992) (0)
- Posters P 8 . 1 Label-free proteomic analysis reveals changes in redox and lipid homeostasis in the liver of cystathionine β-synthase deficient mice (2016) (0)
- Inter-laboratory variability in mass spectrometry-based proteomics workflows (2017) (0)
- Free Energy of Hydration of Drugs - Molecular Descriptors for Solvation Limited Solubility (2006) (0)
- Particle transcytosis across intestinal epithelial cells exposed for Yersinia pseudotuberculosis: gene expression analysis and functional studies (2005) (0)
- Lipoamino acid and glycolipid conjugated peptides enhanced intestinal absorption of an anti-tumour somatostatin analogue (2000) (0)
- Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane (2022) (0)
- Novel Peptidomimetic HCV NS3 Protease Inhibitors Spanning the P2–P1´ Region (2011) (0)
- Microsoft Word-19621610-file00.docx (2014) (0)
- Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance. (2023) (0)
- Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound (2018) (0)
- Liposaccharide based peptide delivery system for tumour selective somatostatin analogues (2000) (0)
- Variability in protein quantification using different mass spectrometry-based proteomics workflows (2017) (0)
- Transcellular delivery of peptide antigens across the intestinal epithelial barrier. In Peptide and protein drug research (1998) (0)
- Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy (2020) (0)
- Effects of obesity and weight loss on global protein expression in human liver and jejunum (2019) (0)
- Conditionally immortalized rat fetal epithelial cell line (2/4/A1): A new model for studying apoptosis in the gut? (1999) (0)
- Bridging differences in CYP activity between donor-matched human liver microsomes and hepatocytes (2019) (0)
- Yersinia Pseudotuberculosis induces apical β1-integrin expression and particle transcytosis in human intestinal epithelial (Caco-2) cells (2005) (0)
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What Schools Are Affiliated With Per Artursson?
Per Artursson is affiliated with the following schools: