Per Artursson

Q: What Schools Are Affiliated With Per Artursson

Per Artursson is affiliated with the following schools: University of Queensland, Uppsala University, Stanford University, University of California, San Francisco, Harvard University

Per Artursson's AcademicInfluence.com Rankings

Per Artursson

Biology

#6848

World Rank

#9651

Historical Rank

Biotechnology

#69

World Rank

#70

Historical Rank

Computational Biology

#122

World Rank

#122

Historical Rank

Molecular Biology

#734

World Rank

#751

Historical Rank

biology Degrees

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Biology

Per Artursson's Degrees

Masters Biotechnology Uppsala University
Bachelors Molecular Biology Uppsala University

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Per Artursson's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. (1991) (1686)
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers (2007) (1000)
Caco-2 monolayers in experimental and theoretical predictions of drug transport. (2001) (940)
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. (1990) (831)
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1 (2001) (765)
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) (1994) (683)
Caco-2 monolayers in experimental and theoretical predictions of drug transport (1996) (560)
Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines (2007) (550)
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement (1997) (540)
Coexistence of passive and carrier-mediated processes in drug transport (2010) (525)
Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo (2001) (492)
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. (2001) (452)
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (2014) (405)
Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers (2004) (371)
Correlation of drug absorption with molecular surface properties. (1996) (351)
Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. (2006) (346)
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) Cells (1996) (332)
Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. (1998) (312)
Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs (2009) (299)
Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions (2012) (294)
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement. (1999) (294)
Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues. (2016) (293)
Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium. (2005) (281)
Expression of specific markers and particle transport in a new human intestinal M-cell model. (2000) (258)
Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond (1997) (257)
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo (1996) (251)
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. (2008) (248)
Cell cultures as models for drug absorption across the intestinal mucosa. (1991) (245)
Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments (1993) (238)
Experimental and computational screening models for the prediction of intestinal drug absorption. (2001) (235)
Absorption classification of oral drugs based on molecular surface properties. (2003) (233)
Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier (1990) (227)
Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. (1990) (226)
Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs. (2014) (225)
Epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. (1992) (216)
Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells (2001) (209)
pH-Dependent Bidirectional Transport of Weakly Basic Drugs Across Caco-2 Monolayers: Implications for Drug–Drug Interactions (2003) (195)
Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo (2003) (195)
Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. (1995) (187)
Diffusion of drugs in native and purified gastrointestinal mucus. (1997) (186)
Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein (1993) (184)
Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors. (1998) (183)
Mechanisms of absorption enhancement and tight junction regulation (1994) (182)
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. (2008) (177)
Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. (2010) (176)
Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs. (1999) (176)
Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method (2005) (172)
PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS (2006) (167)
Accuracy of calculated pH-dependent aqueous drug solubility. (2004) (165)
Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability (2003) (164)
A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial caco 2 cells grown in permeable filter chambers (1991) (163)
Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route (1993) (161)
Economics of the Family (2014) (160)
Experimental and Computational Screening Models for Prediction of Aqueous Drug Solubility (2002) (158)
Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. (1993) (154)
Rapid measurement of intracellular unbound drug concentrations. (2013) (144)
Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models. (2010) (142)
pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers. (2005) (141)
Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11) (2013) (140)
Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption (1995) (139)
The Influence of Intestinal Mucus Components on the Diffusion of Drugs (2004) (134)
Efflux transporters in ulcerative colitis: Decreased expression of BCRP (ABCG2) and Pgp (ABCB1) (2007) (132)
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). (2008) (130)
Applications of epithelial cell culture in studies of drug transport. (2002) (130)
In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes. (2016) (124)
Exploring the role of different drug transport routes in permeability screening. (2005) (123)
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation (2018) (120)
Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs (2009) (120)
A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2) (2007) (120)
Chitosan and the mucosal delivery of biotechnology drugs. (2005) (117)
A new principle for tight junction modulation based on occludin peptides. (2003) (116)
Characterization of polyacryl starch microparticles as carriers for proteins and drugs. (1984) (115)
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil (2016) (114)
Structural and conformational determinants of macrocycle cell permeability. (2016) (113)
Microparticles as potentially orally active immunological adjuvants. (1989) (113)
Preparation of Biodegradable Microparticles Using Solution-Enhanced Dispersion by Supercritical Fluids (SEDS) (1999) (112)
Virtual screening of intestinal drug permeability. (2000) (111)
In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions (2011) (110)
Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber. (1998) (109)
Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions (2014) (109)
Prediction of the Oral Absorption of Low-Permeability Drugs Using Small Intestine-Like 2/4/A1 Cell Monolayers (2003) (106)
Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. (2012) (105)
Validation and development of MTH1 inhibitors for treatment of cancer. (2016) (103)
Contribution of solid-state properties to the aqueous solubility of drugs. (2006) (103)
PEI – a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in mice (2003) (99)
Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. (2006) (98)
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. (2014) (98)
Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure. (2015) (95)
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes. (2017) (92)
A conditionally immortalized epithelial cell line for studies of intestinal drug transport. (1999) (91)
Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate (1997) (90)
Genetic variation in the ATP-binding cassette transporter gene ABCG2 (BCRP) in a Swedish population. (2003) (90)
A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids. (2000) (90)
RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (2014) (89)
Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. (1999) (89)
Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics. (1999) (89)
A Drug Absorption Model Based on the Mucus Layer Producing Human Intestinal Goblet Cell Line HT29-H (1993) (85)
Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method. (2005) (84)
Molecular characteristics for solid-state limited solubility. (2008) (83)
Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs (2003) (82)
CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies. (2001) (82)
Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches (2006) (81)
Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes. (1998) (80)
Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions. (1995) (80)
Global and Local Computational Models for Aqueous Solubility Prediction of Drug-Like Molecules (2004) (79)
Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties. (2008) (79)
Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity. (2004) (78)
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions (2011) (75)
Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum (2006) (75)
Preparation and characterisation of chitosans with oligosaccharide branches. (2002) (73)
Preparation and evaluation of sterically stabilized liposomes: colloidal stability, serum stability, macrophage uptake, and toxicity. (1990) (70)
Theoretical Calculation and Prediction of Caco-2 Cell Permeability Using MolSurf Parametrization and PLS Statistics (1997) (70)
The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells (1993) (68)
Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper (2019) (68)
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery (2017) (67)
Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties (2014) (67)
A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer. (1992) (66)
Theoretical Predictions of Drug Absorption in Drug Discovery and Development (2002) (61)
Gene Expression Profiles in Mouse Lung Tissue after Administration of Two Cationic Polymers Used for Nonviral Gene Delivery (2006) (60)
The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition. (2016) (60)
Prediction of Membrane Permeability to Peptides from Calculated Dynamic Molecular Surface Properties (1999) (60)
Intracellular drug bioavailability: a new predictor of system dependent drug disposition (2017) (59)
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. (2021) (59)
Impact of Extracellular Protein Binding on Passive and Active Drug Transport Across Caco-2 Cells (2005) (58)
Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers (1999) (55)
Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring (2004) (54)
Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity (1999) (54)
An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport: Characterization of Transport Routes (2003) (53)
A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation (2017) (53)
Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis (2008) (53)
Biodegradable microspheres. V: Stimulation of macrophages with microparticles made of various polysaccharides. (1987) (53)
Biodegradable microspheres. IV: Factors affecting the distribution and degradation of polyacryl starch microparticles. (1986) (51)
Absorption of a vasopressin analogue, 1-deamino-8-d-arginine-vasopressin (dDAVP), in a human intestinal epithelial cell line, CaCO-2 (1990) (51)
A modified physiological BCS for prediction of intestinal absorption in drug discovery. (2010) (50)
Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs. (2004) (49)
Lipidic conjugates of luteinizing hormone releasing hormone (LHRH)+ and thyrotropin releasing hormone (TRH)+ that release and protect the native hormones in homogenates of human intestinal epithelial (Caco-2) cells (1994) (49)
Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres. (1999) (47)
Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach (2016) (47)
Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability (2016) (44)
Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9. (2016) (43)
Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice. (2013) (41)
In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation. (2010) (39)
The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox. (2013) (38)
Novel lipoamino acid- and liposaccharide-based system for peptide delivery: application for oral administration of tumor-selective somatostatin analogues. (1999) (37)
A miniaturized nebulization catheter for improved gene delivery to the mouse lung (2005) (36)
Quantifying the impact of transporters on cellular drug permeability. (2015) (36)
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity. (2016) (36)
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. (2016) (33)
Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties (2015) (32)
Biodegradable microspheres. III: some immunological properties of polyacryl starch microparticles. (1986) (32)
Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers (1996) (31)
A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain (2014) (31)
The Critical Role of Passive Permeability in Designing Successful Drugs (2020) (31)
A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies. (2017) (31)
Biodegradable microspheres. I. Duration of action of dextranase entrapped in polyacrylstarch microparticles in vivo. (1984) (31)
Biopharmaceutics of Microparticulate Drug Carriers (1987) (31)
The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers. (2018) (30)
Comparison of CYP3A Activities in a Subclone of Caco-2 Cells (TC7) and Human Intestine (1997) (29)
Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking. (2018) (27)
Direct Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates (2018) (27)
Characterization of surface-modified nanoparticles for in vivo biointeraction. A sedimentation field flow fractionation study. (2005) (26)
Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids. (2018) (24)
Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions. (2016) (24)
A Novel Approach for Prediction of Intestinal Absorption of Drugs in Humans based on Hydrogen Bond Descriptors and Structural Similarity (2001) (24)
Substrate and method dependent inhibition of three ABC‐transporters (MDR1, BCRP, and MRP2) (2017) (24)
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity (2019) (23)
Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures. (2016) (23)
CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box (2018) (22)
Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers. (2003) (22)
Macrophage Stimulation with Some Structurally Related Polysaccharides (1987) (22)
Cell‐type‐resolved proteomic analysis of the human liver (2020) (21)
Studies of membrane permeability and oral absorption 6: Caco-2 and emerging alternatives for prediction of intestinal drug transport: A general overview. (2004) (21)
Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein (2005) (21)
Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1) (1996) (21)
Effects of a new lipid-based drug delivery system on the absorption of low molecular weight heparin (Fragmin) through monolayers of human intestinal epithelial Caco-2 cells and after rectal administration to rabbits (1994) (21)
An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux. (2013) (20)
Determination of the degree of derivatization of acryloylated polysaccharides by Fourier transform proton NMR spectroscopy. (1983) (20)
Breaking the intestinal barrier to deliver drugs (2015) (20)
Intestinal tissue distribution and epithelial transport of the oral immunogen LTB, the B subunit of E. coli heat-labile enterotoxin. (1993) (20)
A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes (2019) (19)
Global variability analysis of mRNA and protein concentrations across and within human tissues (2019) (19)
Receptor-mediated uptake of starch and mannan microparticles by macrophages: relative contribution of receptors for complement, immunoglobulins and carbohydrates. (1988) (18)
Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues. (2002) (18)
Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs. (2003) (18)
Biodegradable microspheres II: Immune response to a heterologous and an autologous protein entrapped in polyacryl starch microparticles. (1985) (18)
Toxicological and absorption enhancing effects of glycofurol 75 and sodium glycocholate in monolayers of human intestinal epithelial (Caco-2) cells (1993) (18)
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket. (2014) (18)
Effect of opsonins on the macrophage uptake of polyacrylstarch microparticles (1986) (18)
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (17)
Oral absorption of lipidic amino acid conjugates (1994) (17)
Tetanus antigen modulates the gene expression profile of aluminum phosphate adjuvant in spleen lymphocytes in vivo (2002) (16)
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy (2020) (16)
Passive permeability and active transport models for the prediction of oral absorption (2007) (16)
Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. (2013) (16)
Gene expression after vaccination of mice with formulations of diphtheria toxoid or tetanus toxoid and different adjuvants: identification of shared and vaccine-specific genes in spleen lymphocytes. (2003) (15)
Biodegradable microspheres. VIII: Killing of Leishmania donovani in cultured macrophages by microparticle-bound primaquine (1987) (15)
Intestinal Absorption: The Role of Polar Surface Area (2004) (15)
The Contribution of Intestinal Secretion to the Dose-Dependent Absorption of Celiprolol (1994) (14)
Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor. (2013) (14)
An Overview of Caco‐2 and Alternatives for Prediction of Intestinal Drug Transport and Absorption (2008) (14)
Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1 (2013) (14)
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. (2017) (13)
Magnetic starch microspheres: Interactions of a microsphere MR contrast medium with macrophages in vitro (1990) (13)
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations (2019) (13)
Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2-P1' Region. (2014) (12)
Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells. (1996) (12)
Studying transport in absorptive epithelia (1996) (12)
Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight (2020) (11)
Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies (2019) (11)
Preparation of sterically stabilized nanoparticles by desolvation from graft copolymers (1990) (11)
Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. (2014) (11)
Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells. (2009) (11)
Expression of 36 drug transporter genes in human intestine, liver, kidney, and organotypic cell lines (2007) (10)
Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat (2013) (10)
Passive Absorption of Drugs in Caco-2 Cells (1991) (10)
Immobilized L-asparaginase-L-glutaminase from Acinetobacter glutaminasificans in microspheres: some properties in vivo and in an extracorporeal system (1987) (9)
Acrylic microspheres in vivo. X. Elimination of circulating cells by active targeting using specific monoclonal antibodies bound to microparticles. (1986) (9)
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound (2018) (9)
Orally Active Antiviral Tripeptide Glycyl-Prolyl-Glycinamide Is Activated by CD26 (Dipeptidyl Peptidase IV) before Transport across the Intestinal Epithelium (2005) (9)
Absorption of thyrotropin-releasing hormone (TRH) and a TRH prodrug in a human intestinal cell line (Caco-2) (1991) (9)
Computational Prospecting for Drug–Transporter Interactions (2013) (8)
Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (2017) (8)
Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors (2011) (8)
Inflammatory response to polyacryl starch microparticles, role of arachidonic acid metabolites (1988) (8)
Quantification and Imaging of Mannitol Transport Through Caco-2 Cell Monolayers Using a Positron-Emitting Tracer (1998) (8)
Chitosans of absorption enhancers of poorly absorbable drugs: Influence of molecular weight and degree of acetylation (1996) (8)
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. (2015) (7)
Cellular and biochemical interactions of macromolecular drug delivery systems (1989) (7)
Biochemical and cellular effects of degraded starch microspheres on macrophages (1989) (6)
The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells. (2016) (6)
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 (2022) (6)
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions (2020) (6)
Cell cultures as models for intestinal peptide transport (1993) (6)
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. (2021) (6)
Expanding the efflux in vitro assay toolbox: A CRISPR-Cas9 edited MDCK cell line with human BCRP and completely lacking canine MDR1. (2020) (6)
In Vitro Characterization of Interactions with Drug Transporting Proteins (2013) (6)
Addendum to 'Quantifying the impact of transporters on cellular drug permeability'. (2015) (6)
Relative contribution of phosphatidylcholine and monoglyceride to absorption enhancement of low molecular weight heparin (Fragmin) by a new lipid-based drug delivery system in monolayers of human intestinal epithelial Caco-2 cells and after rectal administration to rabbits (1994) (6)
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells (2018) (6)
Image-Based Quantification of Cell Debris as a Measure of Apoptosis. (2019) (5)
Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial (2021) (5)
Proteomics-informed identification of luminal targets for in situ diagnosis of inflammatory bowel disease. (2020) (5)
Conditionally Immortalized Intestinal Epithelial Cells: A New Model for Studying Intestinal Epithelial Cell Turnover (1998) (4)
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell) (2019) (4)
Conditions for maintenance of hepatocyte differentiation and function in 3D cultures (2021) (4)
Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity (2022) (4)
A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man. (2016) (4)
Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis (2021) (4)
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity (2022) (4)
Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (2017) (4)
Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase) (2016) (4)
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range (2022) (3)
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles. (2014) (3)
Starch microspheres enhance insulin absorption across epithelial cells by affecting the integrity of tight junctions (1992) (3)
A new approach to chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers (2003) (3)
Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers (2007) (3)
Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity (2022) (3)
Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat (2022) (3)
Regulation of immediate and long term effects of the absorption enhancer sodium caprate in human intestinal epithelial (Caco-2) cells (1996) (3)
A new opening for orally taken peptide drugs (2020) (3)
Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1. (2007) (3)
Development of in vitro M-cell model for macromolecule transport (2004) (3)
X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol (2005) (2)
Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases (2016) (2)
Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1) (2010) (2)
Increased CD9 and β1-integrin expression in human follicle associated epithelium is linked with selective transport into human Peyer´s patches (2005) (2)
Experimental and Theoretical Predictions of Intestinal Drug Absorption (2007) (2)
The Need for Speed-Kinetic Limits of Drug Transporters. (2016) (2)
Cell cultures to assess drug transport and metabolism - Preface (1996) (2)
Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison (2016) (2)
Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer (2021) (2)
Microspheres as drug carriers : some consequences of the delivery of microparticles to the reticuloendothelial system (1985) (2)
The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients. (2022) (1)
To attach or not to attach : factors behind variable adhesion properties of cryopreserved human hepatocytes (2016) (1)
Getting a grip with kirigami (2021) (1)
Comparative proteomics of human liver tissue and hepatocytes reveal systematic differences in proteins determining hepatic drug exposure (2015) (1)
Hepatocyte size fractionation allows dissection of human liver zonation (2021) (1)
LogP-Independent Solubility of Drugs - Molecular Descriptors for Solid-State Limited Solubility (2006) (1)
An alternative explanation for low membrane permeability of highly lipophilic drugs (1996) (1)
Uptake mechanism of ochratoxin A and citrinin through human liver (2010) (1)
Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation (2022) (1)
Comparison and Prediction of Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 (2007) (1)
Experimental and theoretical predictions of intestinal drug absorption, in Computer-assisted lead finding and optimization (1997) (1)
Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ (2021) (1)
Cell Culture Absorption Models – State of the Art (2006) (1)
Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogs (2000) (1)
Biliary Drug Excretion and Drug-drug Interactions in Sandwich Cultured Human Hepatocytes Predicted from Inverted Membrane Vesicles and Targeted Proteomics (2013) (0)
A new approach to absorption enhancement based on the molecular structure of occludin (2000) (0)
IL06 Cell cultures in experimental and theoretical predictions of oral drug absorption (1996) (0)
P48 Prediction of intestinal drug absorption from molecular surface properties (1994) (0)
Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies (2019) (0)
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines. (2017) (0)
Mechanistic modeling of hepatic pitavastatin disposition : a proteomics-informed bottom-up approach (2016) (0)
Influence of nanoparticle properties on their transport through an optimized Human intestine Follicle Associated Epithelium model (2004) (0)
S-01-02 In vitro ADME assays to inform IVIVE-PBK modelling and simulation (2022) (0)
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell) (2019) (0)
Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance (2016) (0)
Effect of cell penetrating peptides on GLP-1R-mediated intracellular delivery of antisense oligonucleotides (2018) (0)
Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1) (2010) (0)
Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis (2021) (0)
Chitosan oligomers as siRNA delivery systems in vitro (2006) (0)
FC29 permeability of drugs with different physico-chemical properties in the human jejunum and Caco-2 monolayers (1994) (0)
mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells (2012) (0)
Polymere de chitosane a taux d'acetylation specifique (1995) (0)
Differential expression of ABC transporters in colonic and rectal mucosa during active and inactive phases of ulcerative colitis (2005) (0)
Proteomic analysis of major cell types in the human liver (2019) (0)
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations (2019) (0)
A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes (2018) (0)
The influence of gastrointestinal mucos and mucin on drug diffusion (1996) (0)
In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions (2011) (0)
P49 Paracellular absorption enhancement in intestinal CACO-2 monolayers by sodium caprate (1994) (0)
Drug-induced gene regulation and function of ABC-transporters in human intestinal epithelial cell lines (2003) (0)
Impact of intracellular bioavailability on metabolic drug-drug interactions (2018) (0)
Erratum to “Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1)” [Int. J. Pharm. 138 (1996) 167]1 (1996) (0)
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration. (2021) (0)
Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat (2013) (0)
HT29-MTX細胞を基にした新規粘液-分泌細胞培養モデルでの親油性薬物分子の輸送 (2001) (0)
Erratum: Structural and conformational determinants of macrocycle cell permeability. (2017) (0)
Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver (2019) (0)
Professor Margareta Hammarlund-Udenaes - A Humble Scientist Shaping Modern Neuropharmacokinetics (2022) (0)
Determination of the transport across CACO-2 cell monolayers of compounds varying in lipophilicity using LC-MS (2000) (0)
Impact of intracellular drug bioavailability on cellular drug response (2016) (0)
Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol (2016) (0)
Proteomics-informed prediction of rosuvastatin clearance in donors with and without obesity (2019) (0)
Global expression variability of proteins across and within human tissues (2019) (0)
A new opening for orally taken peptide drugs (2020) (0)
Apoptosis Detection by Quantification of Cell Debris in Bright-Field Microscopy Images. (2022) (0)
Structure-function relationship in chitosan-mediated gene delivery: controlling polyplex disassembly through chitosan design. (2009) (0)
Impact of drug transporters on intracellular drug concentrations (2016) (0)
Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist. (2017) (0)
GLOBAL MEMBRANE PROTEIN ANALYSIS OF THE HUMAN LIVER: APPLICATION IN PREDICTIONS OF ATORVASTATIN UPTAKE CLEARANCE (2015) (0)
Impact of extracellular protein binding on active drug transport across Caco-2 cells (2005) (0)
A cell free approach for determination of cell specific drug binding based on phospholipid speciation (2018) (0)
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells (2018) (0)
Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1 (2019) (0)
Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (0)
Experimental approaches to understand intracellular based drug bioavailability (2019) (0)
182. Branched Chitosan Oligomers Enhance Gene Delivery In Vitro and after Lung Administration In Vivo (2006) (0)
New cell-based approaches for better predictions of drug transport and cellular drug exposure (2016) (0)
TNF-α, TGF-β, and LTα1/β2 induces particle uptake and augments B-cell-induced particle transcytosis in intestinal epithelial cells (2005) (0)
Development of MS- based immunoassays for Cytochrome P450 and transporter quantification (2016) (0)
Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ (2019) (0)
Meet Our Editorial Board Member (2020) (0)
Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte (2010) (0)
Epithelial and microbial determinants of colonic drug distribution. (2023) (0)
Oligosaccharide branched chitosan oligomers as gene delivery systems in vitro and after lung administration in vivo (2003) (0)
Impact of drug transporters on intracellular unbound drug concentrations (2016) (0)
University of Southern Denmark Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties Implications for Renal Acamprosate Secretion and Drug-Drug Interactions (2020) (0)
The enteropathogen Yersinia pseudotuberculosis induces transcytosis across the human intestinal epithelium (2005) (0)
Correlations between intestinal permeability profiles of polyethylene glycols of different molecular weights in humans, rats and in a human intestinal epithelial cell line (1992) (0)
Posters P 8 . 1 Label-free proteomic analysis reveals changes in redox and lipid homeostasis in the liver of cystathionine β-synthase deficient mice (2016) (0)
Inter-laboratory variability in mass spectrometry-based proteomics workflows (2017) (0)
Free Energy of Hydration of Drugs - Molecular Descriptors for Solvation Limited Solubility (2006) (0)
Particle transcytosis across intestinal epithelial cells exposed for Yersinia pseudotuberculosis: gene expression analysis and functional studies (2005) (0)
Lipoamino acid and glycolipid conjugated peptides enhanced intestinal absorption of an anti-tumour somatostatin analogue (2000) (0)
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane (2022) (0)
Novel Peptidomimetic HCV NS3 Protease Inhibitors Spanning the P2–P1´ Region (2011) (0)
Microsoft Word-19621610-file00.docx (2014) (0)
Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance. (2023) (0)
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound (2018) (0)
Liposaccharide based peptide delivery system for tumour selective somatostatin analogues (2000) (0)
Variability in protein quantification using different mass spectrometry-based proteomics workflows (2017) (0)
Transcellular delivery of peptide antigens across the intestinal epithelial barrier. In Peptide and protein drug research (1998) (0)
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy (2020) (0)
Effects of obesity and weight loss on global protein expression in human liver and jejunum (2019) (0)
Conditionally immortalized rat fetal epithelial cell line (2/4/A1): A new model for studying apoptosis in the gut? (1999) (0)
Bridging differences in CYP activity between donor-matched human liver microsomes and hepatocytes (2019) (0)
Yersinia Pseudotuberculosis induces apical β1-integrin expression and particle transcytosis in human intestinal epithelial (Caco-2) cells (2005) (0)

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