Per Ottar Seglen
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Norwegian physician and professor
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Why Is Per Ottar Seglen Influential?
(Suggest an Edit or Addition)Per Ottar Seglen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Preparation of isolated rat liver cells. (1976) (5192)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
- Why the impact factor of journals should not be used for evaluating research (1997) (1923)
- 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. (1982) (1370)
- Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. (1973) (1059)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- The Skewness of Science (1992) (721)
- Methods for Monitoring Autophagy from Yeast to Human (2007) (668)
- Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion. (1973) (605)
- Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. (2004) (476)
- Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver. (1972) (473)
- Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? (2008) (439)
- Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. (1979) (415)
- Inhibitors of lysosomal function. (1983) (325)
- Prelysosomal convergence of autophagic and endocytic pathways. (1988) (277)
- Autophagy and other vacuolar protein degradation mechanisms (1992) (259)
- Seeing is believing: The impact of electron microscopy on autophagy research (2011) (242)
- Citations and journal impact factors: questionable indicators of research quality (1997) (236)
- Causal relationship between article citedness and journal impact (1994) (231)
- Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes (1990) (215)
- Citation rates and journal impact factors are not suitable for evaluation of research. (1998) (214)
- Autophagy proteins control goblet cell function by potentiating reactive oxygen species production (2013) (213)
- Mass isolation and culture of rat kupffer cells (1975) (202)
- Purification and characterization of autophagosomes from rat hepatocytes. (1998) (178)
- Dependence of hepatocytic autophagy on intracellularly sequestered calcium. (1993) (175)
- Regional Selective Neuronal Degeneration after Protein Phosphatase Inhibition in Hippocampal Slice Cultures: Evidence for a MAP Kinase-Dependent Mechanism (1998) (175)
- Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes. (1980) (162)
- Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. (1982) (156)
- Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system. (1976) (147)
- Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. (1998) (143)
- How Shall I Eat Thee? (2007) (142)
- Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes (1984) (140)
- Autoregulation of glycolysis, respiration, gluconeogenesis and glycogen synthesis in isolated parenchymal rat liver cells under aerobic and anaerobic conditions (1974) (138)
- Proteomic Analysis of Membrane-Associated Proteins from Rat Liver Autophagosomes (2007) (136)
- Proteases and proteolysis in the lysosome (1992) (133)
- Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. (1993) (127)
- Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions. (1995) (125)
- Incorporation of radioactive amino acids into protein in isolated rat hepatocytes. (1976) (124)
- Hepatocyte suspensions and cultures as tools in experimental carcinogenesis. (1979) (122)
- Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy. (2000) (117)
- Non-selective autophagy. (1990) (116)
- Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. (1995) (109)
- Scientific Productivity and Group Size: A Bibliometric Analysis of Norwegian Microbiological Research (2004) (102)
- Binucleation and polyploidization patterns in developmental and regenerative rat liver growth (1993) (102)
- Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats. (1985) (99)
- Energy dependence of autophagic protein degradation in isolated rat hepatocytes. (1987) (99)
- Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity. (1992) (96)
- Induction of tryptophan oxygenase in primary rat liver cell suspensions by glucocorticoid hormone. (1972) (95)
- Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes. (1981) (93)
- Structural aspects of autophagy. (1996) (93)
- Energy dependence of different steps in the autophagic-lysosomal pathway. (1989) (92)
- Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine (1991) (88)
- Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes. (1980) (87)
- Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes. (1980) (87)
- Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors. (1993) (86)
- Modulation of intracellular calcium homeostasis blocks autophagosome formation (2013) (86)
- Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis. (1984) (84)
- DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival (1997) (81)
- Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes. (1978) (80)
- The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas. (1988) (79)
- Protein degradation in isolated rat hepatocytes is inhibited by ammonia. (1975) (79)
- Prelysosomal and lysosomal connections between autophagy and endocytosis. (1992) (79)
- The use of metrizamide as a gradient medium for isopycnic separation of rat liver cells (1974) (76)
- Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization. (1982) (73)
- Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. (2005) (65)
- Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. (2001) (65)
- Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. (2015) (64)
- Ploidy-dependent growth and binucleation in cultured rat hepatocytes. (1994) (64)
- Increase in cis-dichlorodiammineplatinum (II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells. (1986) (64)
- Vanadate inhibits protein degradation in isolated rat hepatocytes. (1981) (61)
- Isolation of Hepatocytes by Collagenase Perfusion (1993) (58)
- Protein-catabolic state of isolated rat hepatocytes (1977) (58)
- From bad to worse: evaluation by Journal Impact. (1989) (58)
- Valine uptake and incorporation into protein in isolated rat hepatocytes. Nature of the precursor pool for protein synthesis. (1978) (56)
- Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. (2001) (56)
- Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis. (1981) (54)
- Attachment of rat hepatocytes in vitro to substrata of serum protein, collagen, or concanavalin A. (1978) (54)
- How representative is the journal impact factor (1992) (54)
- Protein synthesis and protein degradation through the cell cycle of human NHIK 3025 cells in vitro. (1979) (53)
- Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin (2000) (53)
- Effects of aminooxyacetate, alanine and other amino acids on protein synthesis in isolated rat hepatocytes. (1978) (52)
- Role of cAMP in the regulation of hepatocytic autophagy. (1996) (50)
- Inhibition of Autophagy and Multiple Steps in Asialoglycoprotein Endocytosis by Inhibitors of Tyrosine Protein Kinases (Tyrphostins) (*) (1995) (50)
- Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway. (1986) (50)
- Adsorption, simple binding and complex binding of rat hepatocytes to various in vitro substrata. (1980) (50)
- Citation frequency and journal impact: valid indicators of scientific quality? (1991) (49)
- A simple perfusion technique applied to glucocorticoid regulation of tryptophan oxygenase turnover and bile production in the isolated rat liver. (1969) (48)
- The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free medium. (1972) (47)
- Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes. (1997) (46)
- Glycogen synthesis in isolated parenchymal rat liver cells (1973) (44)
- Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes). (1993) (44)
- Changes in ploidy distributions in human liver carcinogenesis. (1988) (44)
- The role of protein accumulation in the cell cycle control of human NHIK 3025 cells (1981) (44)
- Naringin-sensitive Phosphorylation of Plectin, a Cytoskeletal Cross-linking Protein, in Isolated Rat Hepatocytes* (2002) (41)
- Use of [3H]raffinose as a specific probe of autophagic sequestration. (1986) (40)
- Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport. (1981) (37)
- Purification of autophagosomes from rat hepatocytes (2010) (37)
- Autophagy of cytoplasmic bulk cargo does not require LC3 (2016) (36)
- Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium. Its identification as ammonia. (1977) (35)
- Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine. (1990) (35)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Ammonia inhibits protein secretion in isolated rat hepatocytes. (1977) (32)
- Tryptophan oxygenase activation and ascorbate oxidation in whole homogenates from rat liver. (1969) (32)
- Effect of serum step‐down on protein metabolism and proliferation kinetics of NHIK 3025 cells (1981) (32)
- Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes. (1987) (32)
- Autophagosome-associated variant isoforms of cytosolic enzymes. (2000) (31)
- Leucine inhibition of autophagic vacuole formation in isolated rat hepatocytes. (1981) (31)
- Inhibition of Hepatocytic Autophagy by Adenosine, Adenosine Analogs and AMP (1998) (31)
- Pancreatic trypsin activates human promatrix metalloproteinase-2. (2005) (30)
- Analytical methods for the study of liver cell proliferation. (1992) (30)
- Validation of Bibliometric Indicators in the Field of Microbiology: A Norwegian Case Study (2004) (30)
- Isolation of carcinogen-induced diploid rat hepatocytes by centrifugal elutriation. (1986) (29)
- Effects of anaerobiosis, glucose, insulin and glucagon on glycogen metabolism in isolated parenchymal rat liver cells (1973) (29)
- Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. (1992) (28)
- Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments. (1991) (27)
- Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy. (1985) (27)
- Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells. (1989) (26)
- The relation between protein accumulation and cell cycle traverse of human NHIK 3025 cells in unbalanced growth (1982) (26)
- Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate. (1994) (26)
- Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver. (1994) (26)
- Inhibition of hepatocytic protein degradation by inducers of autophagosome accumulation. (1982) (26)
- Structural and physical changes in lysosomes from isolated rat hepatocytes treated with methylamine. (1983) (26)
- 6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes. (1982) (25)
- Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes. (1985) (25)
- Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes. (1983) (25)
- Changes in Cellular Ploidy and Autophagic Responsiveness During Rat Liver Carcinogenesis (1986) (25)
- Macroautophagic cargo sequestration assays. (2015) (23)
- Effect of temperature and divalent cations on the substratum attachment of rat hepatocytes in vitro. (1978) (23)
- Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods. (1985) (23)
- Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes. (1989) (23)
- Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes. (1981) (22)
- Inhibitors and pathways of hepatocytic protein degradation. (1981) (22)
- Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation. (1994) (22)
- Characterization of hepatocytes from carcinogen-treated rats by two-parametric flow cytometry. (1986) (21)
- Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain (2011) (21)
- Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors. (1995) (21)
- Insulin and amino-acid regulation of polysomes in perfused, diabetic rat liver. (1971) (21)
- Protein metabolism and survival of rat hepatocytes in early culture. (1980) (21)
- Effects of amino acid analogues on protein degradation in isolated rat hepatocytes. (1981) (20)
- Enrichment of glucagon sensitive adenyl cyclase upon preparation of parenchymal cells from rat liver. (1972) (20)
- Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. (1989) (20)
- Sequestration assays for mammalian autophagy. (2009) (20)
- Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues. (2009) (19)
- [Ammonia inhibition of protein degradation in isolated rat hepatocytes: quantitative alterations in the lysosomal system (author's transl)]. (1976) (19)
- Inhibition of autophagic sequestration and endogenous protein degradation in isolated rat hepatocytes by methylated adenosine derivatives (1981) (19)
- Cell biology of hepatocarcinogenesis. (1990) (18)
- Hepatocytic autophagy. (1991) (18)
- 2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism. (1988) (17)
- Regulation of tyrosine transaminase degradation in the isolated perfused rat liver by cycloheximide and insulin. (1971) (17)
- Trapping of electro-injected [14C]sucrose by hepatocyte mitochondria: a mechanism for cellular autofiltration? (1984) (16)
- Vanadate inhibition of hepatocytic autophagy. Calcium-modulated and osmolality-modulated antagonism by asparagine. (1995) (16)
- Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes. (1987) (16)
- Tyrosine transaminase degradation in perfused liver after inhibition of protein synthesis by cycloheximide. (1969) (16)
- An effect of ethanol administration on tryptophan oxygenase in the perfused rat liver. Decreased enzyme synthesis dependent on low perfusate pH. (1972) (15)
- Novel steps in the autophagic‐lysosomal pathway (2015) (15)
- Emergence of a population of small diploid hepatocytes during hepatocarcinogenesis (1985) (15)
- Amino acid control of protein degradation in normal and leukemic human lymphocytes. (1984) (15)
- Comigration of Two Autophagosome-Associated Dehydrogenases on Two-Dimensional Polyacrylamide Gels (2005) (15)
- Subcellular distribution of proteolytically generated valine in isolated rat hepatocytes. (2005) (14)
- Convergence of autophagic and endocytic pathways at the level of the lysosome (1987) (14)
- Studies on the mitoinhibitory efect of orotic acid on heptocytes in primary culture (1990) (14)
- Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. (2004) (14)
- A Simple Cargo Sequestration Assay for Quantitative Measurement of Nonselective Autophagy in Cultured Cells. (2017) (13)
- A novel method for the study of autophagy: destruction of hepatocytic lysosomes, but not autophagosomes, by the photosensitizing porphyrin tetra(4-sulphonatophenyl)porphine. (1997) (13)
- Autophagic-lysosomal and mitochondrial sequestration of [14C]sucrose. Density gradient distribution of sequestered radioactivity. (1985) (13)
- Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, andN 6-Mercaptopurine Riboside (1998) (13)
- Role of cyclic nucleotides in the control of hepatic autophagy. (1991) (12)
- Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. (2003) (12)
- Autophagy and protein degradation in isolated rat hepatocytes. (1985) (12)
- Inverkanstal som fördelningsinstrument. Ej accepterat av tidskrifter i Norden. (1994) (12)
- Radiolabelled sugars as probes of hepatocytic autophagy. (1986) (12)
- Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas (1990) (10)
- [Use of citation analysis and other bibliometric methods in evaluation of the quality of research]. (1989) (10)
- Use of electrical methods in the study of hepatocytic autophagy. (1986) (9)
- Cell cycle traverse and protein metabolism in human NHIK 3025 cells: The role of anchorage (1985) (9)
- Growth-related alterations during liver carcinogenesis: effect of promoters. (1990) (9)
- Casual Relationship between Article Citedness and Journal Impact (1994) (8)
- Amino acid and energy requirements for rat hepatocytes in primary culture (2007) (8)
- Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture. (1990) (8)
- Quantification of scientific article contents (2005) (8)
- Kinetics of entry into S-phase and into the G1-phase of the subsequent cell cycle for synchronized NHIK 3025 cells (1981) (7)
- The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle (1994) (7)
- Effects of antibiotics on protein synthesis and degradation in primary cultures of rat hepatocytes (2007) (7)
- Protein degradation in isolated rat hepatocytes. (1977) (7)
- Nuclear Alterations in Liver Carcinogenesis: The Role of Non-Polyploidizing Growth (1988) (7)
- Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes. (1983) (6)
- PROTEIN TURNOVER IN ISOLATED RAT HEPATOCYTES (1978) (6)
- [Evaluation of scientific quality using citation analysis and other bibliometric methods]. (1989) (6)
- Morphometric electron microscopic and biochemical study of isolated and enucleated rat liver cells (LC) (1975) (6)
- Control of glycogen metabolism in isolated rat liver cells by glucose, insulin and glucagon. (1974) (6)
- Amino acid and energy requirements for rat hepatocytes in primary culture (2007) (6)
- Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells. (1991) (5)
- Sequestration and hydrolysis of electroinjected [14C]lactose as a means of investigating autophagosome-lysosome fusion in isolated rat hepatocytes. (1985) (5)
- Insulin inhibition of tyrosine transaminase degradation in the isolated, perfused rat liver. (1968) (4)
- Autophagic-Endocytic Interactions in Hepatocytes (1992) (4)
- The Norse god of autophagy (2010) (4)
- Proliferation of diploid hepatocytes and nonparenchymal (oval) cells during rat-liver regeneration in the presence of 2-acetylaminofluorene. (1994) (4)
- Effects of amino acids and amino acid analogues on lysosomal protein degradation in isolated rat hepatocytes. (1981) (4)
- Transplantation of Preneoplastic Rat Hepatoeytes by Intraportal Injection (1987) (4)
- [The pelican]. (1974) (3)
- Pathways of intracellular sequestration and protein degradation in isolated rat hepatocytes. (1985) (3)
- Nuclear Alterations During Hepatocarcinogenesis: Promotion by 2-Acetylaminofluorene (1988) (3)
- Evaluating Biology: A Scientometric Study of a University Biology Department (2001) (2)
- Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth. (1990) (2)
- [The impact factor as an instrument of allocation. Not accepted by the journals in Scandinavia]. (1994) (2)
- Protein-catabolic stage of isolated rat hepatocytes. (1977) (2)
- In vitro ischemia and phosphatase 1/2a inhibition cause selective neuronal death in hippocampal slice cultures (1996) (1)
- Proceedings: Carbohydrate metabolism of isolated parenchymal rat liver cells. (1974) (1)
- [Toothpicks and toothbrushes]. (1966) (1)
- An effect of glucocorticoid hormone on the nuclear ribonucleoprotein of rat liver. (1970) (1)
- Role of Calcium, Protein Phosphorylation and the Cytoskeleton in Hepatocytic Autophagy (1993) (1)
- PROTEIN DEGRADATION IN HEPATOCYTES (1981) (1)
- Measurement of Bulk Autophagy by a Cargo Sequestration Assay. (2019) (1)
- [Drug effects on enzyme synthesis]. (1970) (0)
- [On the early history of dental drills]. (1965) (0)
- Endocytosis of Asialo-glycoproteins and Attachment to Asialo-glycoproteins of Hepatocytes from Carcinogen-Treated Rats (1987) (0)
- Autophagic sequestration of radiolabelled sugars introduced into isolated rat hepatocytes by reversible electropermeabilisation (1986) (0)
- [TOOTH KEYS]. (1965) (0)
- [Dental extraction forceps]. (1971) (0)
- [Extraction forceps]. (1967) (0)
- [How should the research be directed?]. (1994) (0)
- Av bormaskinens forhistorie. (1965) (0)
- [The university's odontological collection]. (1975) (0)
- [Extraction devices]. (1971) (0)
- Novel steps in the autophagic-lysosomal fluxes of phagophores and cytosolic cargo (2015) (0)
- [The history of instruments for cleaning the teeth]. (1968) (0)
- The inhibition of polyploidization of carcinogen-treated hepatocytes persists in primary carcinogenesis and after transplantation (1987) (0)
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What Schools Are Affiliated With Per Ottar Seglen?
Per Ottar Seglen is affiliated with the following schools:
