Perry A. Frey
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American biochemist
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Biology
Perry A. Frey's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry Stanford University
Why Is Perry A. Frey Influential?
(Suggest an Edit or Addition)According to Wikipedia, Perry A. Frey is professor emeritus of biochemistry at the University of Wisconsin–Madison. He was elected to the National Academy of Sciences in 1998. Research in his laboratory centered on the elucidation of enzymatic reaction mechanisms.
Perry A. Frey's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A low-barrier hydrogen bond in the catalytic triad of serine proteases. (1994) (571)
- The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose (1996) (440)
- The Low Barrier Hydrogen Bond in Enzymatic Catalysis* (1998) (417)
- The Radical SAM Superfamily (2008) (271)
- Understanding enzymic catalysis: the importance of short, strong hydrogen bonds. (1997) (221)
- The Radical SAM Superfamily. (2008) (209)
- Bond order and charge localization in nucleoside phosphorothioates. (1985) (206)
- S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin? (2003) (194)
- Radical mechanisms of enzymatic catalysis. (2001) (184)
- S-adenosylmethionine as an oxidant: the radical SAM superfamily. (2007) (154)
- Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli. (1997) (153)
- The stereochemistry of the conversion of D and L 1,2-propanediols to propionaldehyde. (1966) (152)
- The ubiquity of iron. (2012) (149)
- Enzymatic Reaction Mechanisms (2007) (148)
- Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism. (1996) (147)
- The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. (2005) (140)
- Climate change and the integrity of science. (2010) (137)
- A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond. (1997) (127)
- Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. (1996) (126)
- Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. (1997) (110)
- Free radical mechanisms in enzymology. (2006) (108)
- Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase. (2003) (105)
- The role of S-adenosylmethionine in the lysine 2,3-aminomutase reaction. (1987) (99)
- The molecular structure of UDP‐galactose 4‐epimerase from Escherichia coli determined at 2.5 Å resolution (1992) (96)
- A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. (2004) (93)
- Importance of organic radicals in enzymic cleavage of unactivated carbon-hydrogen bonds (1990) (93)
- S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance. (1998) (92)
- Studies on the mechanism of action of cobamide coenzymes. Chemical properties of the enzyme-coenzyme complex. (1966) (83)
- Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase. (1992) (82)
- Characterization of an allylic analogue of the 5'-deoxyadenosyl radical: an intermediate in the reaction of lysine 2,3-aminomutase. (2001) (80)
- High‐resolution X‐ray structure of UDP‐galactose 4‐epimerase complexed with UDP‐phenol (1996) (78)
- Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution. (1995) (76)
- Studies on the mechanism of hydrogen transfer in the cobamide coenzyme-dependent dioldehydrase reaction. (1967) (75)
- Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase. (2000) (75)
- Radical mechanisms of S-adenosylmethionine-dependent enzymes. (2001) (74)
- Review: Strong hydrogen bonding in molecules and enzymatic complexes (2001) (72)
- Studies on the mechanism of hydrogen transfer in the coenzyme B12 dependent dioldehydrase reaction II. (1971) (71)
- Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme. (2007) (71)
- Characterization of iron-sulfur clusters in lysine 2,3-aminomutase by electron paramagnetic resonance spectroscopy. (1992) (70)
- Lysine 2,3-aminomutase. Support for a mechanism of hydrogen transfer involving S-adenosylmethionine. (1989) (69)
- The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer. (1996) (67)
- The role of the B12 coenzyme in the conversion of 1,2-propanediol to propionaldehyde. (1966) (67)
- Spectroscopic Evidence for the Participation of an Allylic Analogue of the 5‘-Deoxyadenosyl Radical in the Reaction of Lysine 2,3-Aminomutase (1999) (67)
- Stereochemistry of enzymatic reactions of phosphates (1982) (66)
- Unambiguous determination of the stereochemistry of nucleotidyl transfer catalyzed by DNA polymerase I from Escherichia coli. (1981) (66)
- Cloning, Sequencing, Heterologous Expression, Purification, and Characterization of Adenosylcobalamin-dependentd-Lysine 5,6-Aminomutase from Clostridium sticklandii * (2000) (65)
- Methane monooxygenase catalyzed oxygenation of 1,1-dimethylcyclopropane. Evidence for radical and carbocationic intermediates. (1990) (65)
- Lysine 2,3‐aminomutase: is adenosylmethionine a poor man's adenosylcobalamin? (1993) (65)
- Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin. (1998) (64)
- A reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol. (1971) (63)
- Stereochemical courses of nucleotidyltransferase and phosphotransferase action. Uridine diphosphate glucose pyrophosphorylase, galactose-1-phosphate uridylyltransferase, adenylate kinase, and nucleoside diphosphate kinase. (1979) (61)
- Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. (2004) (59)
- Enzymatic and 32P nuclear magnetic resonance study of adenylate kinase-catalyzed stereospecific phosphorylation of adenosine 5'-phosphorothioate. (1977) (59)
- Low-barrier hydrogen bonding in molecular complexes analogous to histidine and aspartate in the catalytic triad of serine proteases. (1995) (59)
- An organic radical in the lysine 2,3-aminomutase reaction. (1992) (59)
- Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin. (1998) (57)
- Observation of a second substrate radical intermediate in the reaction of lysine 2,3-aminomutase: a radical centered on the beta-carbon of the alternative substrate, 4-thia-L-lysine. (1995) (55)
- Cofactor dependence of reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase. (2006) (55)
- Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism. (2000) (51)
- Activation of lysine 2,3-aminomutase by S-adenosylmethionine. (1990) (49)
- Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase. (2001) (49)
- Metal cofactors of lysine-2,3-aminomutase. (1991) (49)
- UDP-glucose pyrophosphorylase. Stereochemical course of the reaction of glucose 1-phosphate with uridine-5'[1-thiotriphosphate]. (1978) (48)
- Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin. (2001) (47)
- Stereochemical course of thiophosphoryl group transfer catalyzed by adenylate kinase (1978) (47)
- Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site. (1997) (46)
- Galactose-1-phosphate uridylyltransferase: identification of histidine-164 and histidine-166 as critical residues by site-directed mutagenesis. (1989) (44)
- Identification of lysine 153 as a functionally important residue in UDP-galactose 4-epimerase from Escherichia coli. (1993) (44)
- Characterization of enzymatic processes by rapid mix-quench mass spectrometry: the case of dTDP-glucose 4,6-dehydratase. (2000) (42)
- The strongly conserved lysine 256 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase is essential for phosphoryl transfer. (1998) (42)
- Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. (2007) (41)
- Lysine 2,3-aminomutase: rapid mix-freeze-quench electron paramagnetic resonance studies establishing the kinetic competence of a substrate-based radical intermediate. (1996) (40)
- Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: the case of lysine 2,3-aminomutases. (2006) (40)
- Haptenic Properties of Paralytic Shellfish Poison Conjugated to Proteins by Formaldehyde Treatment (1964) (39)
- Studies on Escherichia coli pyruvate dehydrogenase complex. I. Effect of bromopyruvate on the catalytic activities of the complex. (1972) (38)
- Travels with carbon-centered radicals. 5'-deoxyadenosine and 5'-deoxyadenosine-5'-yl in radical enzymology. (2014) (38)
- Strong Hydrogen Bonds in Aqueous and Aqueous−Acetone Solutions of Dicarboxylic Acids: Activation Energies for Exchange and Deuterium Fractionation Factors (2000) (38)
- Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate. (1989) (38)
- Synthesis of Rp and Sp [alpha-18O]ADP from Sp and Rp beta-cyanoethyl-adenosine 5'[1-thiodiphosphate]. (1982) (38)
- Chiral phosphorothioates: stereochemical analysis of enzymatic substitution at phosphorus. (1989) (38)
- Galactose 1-phosphate uridylyltransferase. Isolation of a uridylyl-enzyme intermediate. (1974) (37)
- Identification of cis-ethanesemidione as the organic radical derived from glycolaldehyde in the suicide inactivation of dioldehydrase and of ethanolamine ammonia-lyase. (2000) (37)
- Synthesis of UDP-4-deoxy-4-fluoroglucose and UDP-4-deoxy-4-fluorogalactose and their Interactions with Enzymes of Nucleotide Sugar Metabolism (1994) (37)
- Lysine 2,3-Aminomutase from Clostridium subterminale SB4: Mass Spectral Characterization of Cyanogen Bromide-Treated Peptides and Cloning, Sequencing, and Expression of the Gene kamA in Escherichia coli (2000) (37)
- HYDROGEN BONDING IN COMPLEXES OF CARBOXYLIC ACIDS WITH 1-ALKYLIMIDAZOLES :STERIC AND ISOTOPIC EFFECTS ON LOW BARRIER HYDROGEN BONDING (1999) (36)
- Synthesis of nucleoside [18O]pyrophosphorothioates with chiral [18O]phosphorothioate groups of known configuration. Stereochemical orientations of enzymic phosphorylations of chiral [18O]phosphorothioates (1978) (36)
- How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy. (2006) (35)
- Are There Strong Hydrogen Bonds in Aqueous Solutions (1998) (35)
- Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase. (2001) (35)
- Galactose-1-phosphate uridylyltransferase: rate studies confirming a uridylyl-enzyme intermediate on the catalytic pathway. (1974) (35)
- Synthesis of chiral [18O]phosphorothioate analogs of adenine nucleotides (1982) (34)
- Studies on the mechanism of action of uridine diphosphate galactose 4-epimerase. II. Substrate-dependent reduction by sodium borohydride. (1973) (34)
- Phenylalanine Hydroxylase from Chromobacterium violaceum (1998) (33)
- Radicals in enzymatic reactions. (1997) (33)
- Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase. (2002) (33)
- Cloning, expression, purification, cofactor requirements, and steady state kinetics of phosphoketolase-2 from Lactobacillus plantarum. (2008) (33)
- Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement. (1995) (32)
- Chemical model for the pyridoxal 5'-phosphate dependent lysine aminomutases (1990) (32)
- Molecular properties of lysine-2,3-aminomutase. (1991) (32)
- Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate. (2001) (32)
- Fluorescence and nucleotide binding properties of Escherichia coli uridine diphosphate galactose 4-epimerase: support for a model for nonstereospedific action. (1977) (32)
- 5'-Peroxyadenosine and 5'-peroxyadenosylcobalamin as intermediates in the aerobic photolysis of adenosylcobalamin. (2007) (31)
- Standard free energy change for the hydrolysis of the alpha, beta-phosphoanhydride bridge in ATP. (1995) (31)
- Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site. (2001) (31)
- Lysine 2,3-aminomutase and the mechanism of the interconversion of lysine and beta-lysine. (2006) (31)
- Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme. (1982) (31)
- Quaternary structure of pyruvate dehydrogenase complex from Escherichia coli. (1985) (30)
- Nucleophile in the active site of Escherichia coli galactose-1-phosphate uridylyltransferase: degradation of the uridylyl-enzyme intermediate to N3-phosphohistidine. (1979) (30)
- Galactose mutarotase: purification, characterization, and investigations of two important histidine residues. (1998) (30)
- Esherichia coli pyruvate dehydrogenase complex: improved purification and the flavin content. (1975) (30)
- Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. (1982) (30)
- Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases. (2011) (30)
- Galactose-1-phosphate uridylyltransferase: isolation and properties of a uridylyl-enzyme intermediate. (1977) (30)
- Synthesis and properties of 2-acetylthiamin pyrophosphate: an enzymatic reaction intermediate. (1987) (29)
- Intermediates in Reductive Transacetylation Catalyzed by Pyruvate Dehydrogenase Complex a (1989) (29)
- Chemical and stereochemical actions of UDP-galactose 4-epimerase. (2013) (29)
- Galactose-1-phosphate uridylyltransferase: detection, isolation, and characterization of the uridylyl enzyme. (1982) (29)
- [14] Stereochemistry of selected phosphotransferases and nucleotidyltransferases (1982) (29)
- Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. (2002) (28)
- Uridine diphosphate galactose-4-epimerase. Uridine monophosphate-dependent reduction by alpha- and beta-D-glucose. (1975) (28)
- Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana. (2006) (28)
- Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells. (1996) (28)
- Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase: revised amino acid sequence, site-directed mutagenesis, and microenvironment characteristics of cysteines 365 and 458. (1995) (28)
- Stereochemical course of a phosphokinase using a chiral [18O]phosphorothioate. Comparison with the transfer of a chiral [16O,17O,18O]phosphoryl group. (1980) (27)
- Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate. (1984) (27)
- Strong hydrogen bonding in chymotrypsin and other serine proteases (2004) (27)
- Remodeling hexose-1-phosphate uridylyltransferase: mechanism-inspired mutation into a new enzyme, UDP-hexose synthase. (1990) (27)
- Chiral [18O]phosphorothioates. The stereochemical course of thiophosphoryl group transfer catalyzed by nucleoside phosphotransferase. (1979) (27)
- Synthesis of undecagold cluster molecules as biochemical labeling reagents. 2. Bromoacetyl and maleimido undecagold clusters. (1984) (26)
- Stereochemical retention of the configuration in the action of Fhit on phosphorus-chiral substrates. (1999) (26)
- Radical mechanisms in adenosylmethionine- and adenosylcobalamin-dependent enzymatic reactions. (2000) (26)
- Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase. (2001) (26)
- The deuterium isotope effect on the NMR signal of the low-barrier hydrogen bond in a transition-state analog complex of chymotrypsin. (2000) (26)
- A Simplified Procedure for Synthesizing Nucleoside 1-Thiotriphosphates: dATPαS, dGTPαS, UTPαS, and dTTPαS (1994) (25)
- Effects of oxygen-17 and oxygen-18 on phosphorus-31 NMR: further investigation and applications (1983) (25)
- Cobalamin Coenzymes in Enzymology (2010) (25)
- Synthesis of undecagold cluster molecules as biochemical labeling reagents. 1. Monoacyl and mono[N-(succinimidooxy)succinyl] undecagold clusters. (1984) (25)
- Identification of lysine 346 as a functionally important residue for pyridoxal 5'-phosphate binding and catalysis in lysine 2, 3-aminomutase from Bacillus subtilis. (2001) (24)
- UDP-galactose 4-epimerase: NAD+ content and a charge-transfer band associated with the substrate-induced conformational transition. (1996) (24)
- Acetylation stoichiometry of Escherichia coli pyruvate dehydrogenase complex. (1977) (24)
- Galactose-1-phosphate uridylyltransferase. Purification of the enzyme and stereochemical course of each step of the double-displacement mechanism. (1986) (24)
- Kinetic and biochemical analysis of the mechanism of action of lysine 5,6-aminomutase. (2003) (23)
- S-adenosylmethionine: a 'poor man's coenzyme B12' in the reaction of lysine 2,3-aminomutase. (1998) (23)
- Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: insight into the molecular basis of galactosemia. (1998) (23)
- Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. (2009) (23)
- Low-barrier hydrogen bonds. (1995) (22)
- Dihydrolipoyl transacetylase of Escherichia coli. Formation of 8-S-acetyldihydrolipoamide. (1986) (22)
- Escherichia coli pyruvate dehydrogenase complex: particle masses of the complex and component enzymes measured by scanning transmission electron microscopy. (1985) (22)
- Gentamicin nucleotidyltransferase. Stereochemical inversion at phosphorus in enzymatic 2'-deoxyadenylyl transfer to tobramycin. (1986) (22)
- Pyruvate dehydrogenase complex of Escherichia coli. Thiamin pyrophosphate and NADH-dependent hydrolysis of acetyl-CoA. (1985) (22)
- Evidence for a strong hydrogen bond in the catalytic dyad of transition-state analogue inhibitor complexes of chymotrypsin from proton-triton NMR isotope shifts. (2002) (22)
- The importance of binding energy in catalysis of hydride transfer by UDP-galactose 4-epimerase: a 13C and 15N NMR and kinetic study. (1993) (22)
- Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase. (2009) (22)
- Fluoropyruvate: an unusal substrate for Escherichia coli pyruvate dehydrogenase. (1978) (22)
- Phosphorus-oxygen bond order in adenosine 5'-O-phosphorothioate dianion (1984) (22)
- 2-Acetylthiamin pyrophosphate (acetyl-TPP) pH-rate profile for hydrolysis of acetyl-TPP and isolation of acetyl-TPP as a transient species in pyruvate dehydrogenase catalyzed reactions. (1989) (21)
- The stereochemical course of thiophosphoryl group transfer catalyzed by adenosine kinase. (1980) (21)
- Importance of Organic Radicals in Enzymatic Cleavage of Unactivated C‐ H Bonds (1991) (21)
- Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron. (1999) (21)
- Mutation Arg336 to Lys in Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase originates an enzyme with increased oxaloacetate decarboxylase activity (2001) (20)
- Characterization of the transition-state structure of the reaction of kanamycin nucleotidyltransferase by heavy-atom kinetic isotope effects. (2001) (20)
- Stereochemical course of thiophosphoryl group transfer catalyzed by mitochondrial phosphoenolpyruvate carboxykinase. (1984) (20)
- Pyruvate dehydrogenase and 3-fluoropyruvate: chemical competence of 2-acetylthiamin pyrophosphate as an acetyl group donor to dihydrolipoamide. (1986) (20)
- Galactose-1-phosphate uridylyltransferase from Escherichia coli, a zinc and iron metalloenzyme. (1995) (20)
- Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer. (2002) (20)
- Acid-base catalysis by UDP-galactose 4-epimerase: correlations of kinetically measured acid dissociation constants with thermodynamic values for tyrosine 149. (2001) (20)
- The stereochemical configuration of Mn(II) . ADP at the active site of creatine kinase elucidated by electron paramagnetic resonance with Rp [alpha-17O]ADP and Sp [alpha-17O]ADP. (1982) (19)
- Radical intermediates in the reaction of lysine 2,3-aminomutase (1999) (19)
- Discrete monomeric metaphosphate anion as an intermediate in the hydrolysis of .mu.-monothiopyrophosphate (1992) (19)
- A novel lysine 2,3-aminomutase encoded by the yodO gene of bacillus subtilis: characterization and the observation of organic radical intermediates. (2000) (19)
- Stereochemical course of thiophosphoryl transfer catalyzed by cytosolic phosphoenolpyruvate carboxykinase. (1986) (18)
- Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin. (2007) (18)
- Mevalonate-5-diphosphate decarboxylase: stereochemical course of ATP-dependent phosphorylation of mevalonate 5-diphosphate. (1986) (18)
- 2-ketoacid dehydrogenase complexes of Escherichia coli: stereospecificities of the three components for (R)-lipoate. (1989) (18)
- The isolation, purification, and preliminary crystallographic characterization of udp‐galactose‐4‐epimerase from Escherichia coli (1991) (18)
- Mapping the lipoyl groups of the pyruvate dehydrogenase complex by use of gold cluster labels and scanning transmission electron microscopy. (1994) (18)
- The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit. (2004) (17)
- Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. (2003) (17)
- Evidence implicating cyclo-diphosphates as intermediates in reactions of nucleoside phosphorothioates with cyanogen bromide (1982) (17)
- Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. (2004) (17)
- Effect of ion pairing on bond order and charge localization in alkyl phosphorothioates (1988) (17)
- Analysis of the Cob(II)alamin-5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase. (2006) (16)
- Galactose mutarotase: pH dependence of enzymatic mutarotation. (2003) (16)
- Radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase: role of tyrosine-263α as revealed by electron paramagnetic resonance spectroscopy. (2011) (16)
- The participation of the two non-equivalent C-5' hydrogens of B 12-coenzyme in the catalytic process. (1967) (16)
- Escherichia coli pyruvate dehydrogenase complex. Site coupling in electron and acetyl group transfer pathways. (1978) (16)
- The stereochemistry of the conversion of propanediol to propionaldehyde (1965) (16)
- UDP-galactose 4-epimerase. Phosphorus-31 nuclear magnetic resonance analysis of NAD+ and NADH bound at the active site. (1989) (15)
- alpha-Ketoglutarate dehydrogenase complex of Escherichia coli. A hybrid complex containing pyruvate dehydrogenase subunits from pyruvate dehydrogenase complex. (1985) (15)
- Escherichia coli uridine diphosphate galactose 4-epimerase: circular dichroism of the protein and protein bound dihydronicotinamide adenine dinucleotide. (1978) (15)
- Studies on the Mechanism of Action of Uridine Diphosphate-galactose-4-epimerase I. AN AMBIGUITY IN THE CHEMICAL TRAPPING OF A PROPOSED KETO-INTERMEDIATE BY NaB3H4 (1972) (15)
- Uridine diphosphate galactose 4-epimerase: nucleotide and 8-anilino-1-naphthalenesulfonate binding properties of the substrate binding site. (1978) (15)
- Mechanism-based inhibition reveals transitions between two conformational states in the action of lysine 5,6-aminomutase: a combination of electron paramagnetic resonance spectroscopy, electron nuclear double resonance spectroscopy, and density functional theory study. (2013) (14)
- Comments on a proposed mechanism of action of B12 coenzyme. (1970) (14)
- Characterization and activation of naturally occurring abortive complexes of UDP-galactose 4-epimerase from Escherichia coli. (1994) (14)
- Synthesis and Characterization of 3‘,4‘-Anhydroadenosylcobalamin: A Coenzyme B12 Analogue with Unusual Properties (2000) (14)
- 4 Nucleotidyltransferases and Phosphotransferases: Stereochemistry and Covalent Intermediates (1992) (13)
- Kinetic and spectroscopic evidence of negative cooperativity in the action of lysine 2,3-aminomutase. (2010) (13)
- Synthesis of undecagold labeling compounds and their applications in electron microscopic analysis of multiprotein complexes. (1999) (13)
- UMP-dependent reduction of UDP-galactose 4-epimerase-NAD+ complex by sodium cyanoborohydride (1974) (13)
- Preparation and characterization of a bifunctional fusion enzyme composed of UDP-galactose 4-epimerase and galactose-1-P uridylyltransferase. (1994) (12)
- The stereochemical course of thiophosphoryl group transfer catalyzed by T4 polynucleotide kinase. (1981) (12)
- Electrostatic Acceleration of Enolization in Cationic Ketones (1996) (12)
- Pyruvate dehydrogenase complex of Escherichia coli: radial mass analysis of subcomplexes by scanning transmission electron microscopy. (1986) (12)
- Standard Free Energy for the Hydrolysis of Adenylylated T4 DNA Ligase and the Apparent pK a of Lysine 159* (1999) (12)
- Coenzymes and Radicals (2001) (12)
- Stereochemical course of phosphoanhydride synthesis (1983) (12)
- The mechanism of the hydrolysis of .mu.-monothiopyrophosphate (1991) (11)
- Combined Fmoc-Alloc strategy for a general SPPS of phosphoserine peptides; preparation of phosphorylation-dependent tau antisera. (1997) (11)
- Uridine diphosphate galactose 4-epimerase. pH dependence of the reduction of NAD+ by a substrate analog. (1988) (11)
- Correlation of Electronic Effects in N-Alkylnicotinamides with NMR Chemical Shifts and Hydride Transfer Reactivity. (1996) (11)
- Serine Protease Catalysis: A Computational Study of Tetrahedral Intermediates and Inhibitory Adducts. (2016) (11)
- Low-Barrier Hydrogen Bonding in Aqueous and Aprotic Solutions of Dicarboxylic Acids: Spectroscopic Characterization (1998) (11)
- Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida. (2004) (10)
- The nucleotide sequence of the gal T gene of Escherichia coli. (1987) (10)
- Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase. (2006) (10)
- An adaptable spectroelectrochemical titrator: the midpoint reduction potential of the iron-sulfur center in lysine 2,3-aminomutase. (2006) (10)
- The pH Dependence for the Hydrolysis of Uridine 5′-Phosphoimidazolates (1993) (10)
- Phosphorus-sulfur bond order in phosphorothioate anions (1986) (10)
- A new method for synthesizing phosphoanhydrides: synthesis of adenosine 5'-(2-thiodiphosphate) and adenosine 5'-(2-thiotriphosphate) (1984) (10)
- 2-Acetylthiamin pyrophosphate: an enzyme-bound intermediate in thiamin pyrophosphate-dependent reactions. (1989) (10)
- Characterization of a low barrier hydrogen bond in the active site of chymotrypsin (2002) (9)
- Re‐face stereospecificity at C4 of NAD(P) for alcohol dehydrogenase from Methanogenium organophilum and for (R)‐2‐hydroxyglutarate dehydrogenase from Acidaminococcus fermentans as determined by 1H‐NMR spectroscopy (1996) (9)
- Reaction of uridine diphosphate galactose 4-epimerase with a suicide inactivator. (1990) (9)
- Suicide Inactivation of Dioldehydrase by 2-Chloroacetaldehyde: Formation of the `cis-Ethanesemidione' Radical, and the Role of a Monovalent Cation (2003) (9)
- Basis for the equilibrium constant in the interconversion of l-lysine and l-beta-lysine by lysine 2,3-aminomutase. (2007) (8)
- Rapid hydrogen exchange at the acetyl (C2) methyl group of acetylthiamine pyrophosphate (1993) (8)
- Synthesis of undecagold cluster molecules as biochemical labeling reagents. 3. Dimeric cluster with a single reactive amino group. (1984) (8)
- Stereochemistry of metal ion coordination to the terminal thiophosphoryl group of adenosine 5'-O-(3-thiotriphosphate) at the active site of pyruvate kinase. (1993) (8)
- Kinetic characterization of transient free radical intermediates in reaction of lysine 2,3-aminomutase by EPR lineshape analysis. (2002) (7)
- 13C NMR analysis of electrostatic interactions between NAD+ and active site residues of UDP-galactose 4-epimerase: implications for the activation induced by uridine nucleotides. (2001) (7)
- Escherichia coli alpha-ketoglutarate dehydrogenase complex. (1984) (7)
- 1H, 13C, and 31P nuclear magnetic resonance spectral assignments for tobramycin, 2''-(adenosine-5'-phosphoryl)-tobramycin and 2''-(adenosine-5'-thiophosphoryl)-tobramycin. (1990) (7)
- The role of radicals in enzymatic processes. (2001) (7)
- Chapter 5 Stereochemistry of enzymatic substitution at phosphorus (1982) (7)
- Rapid mix-quench MALDI-TOF mass spectrometry for analysis of enzymatic systems. (2002) (7)
- Adenosyl coenzyme and pH dependence of the [4Fe-4S]2+/1+ transition in lysine 2,3-aminomutase. (2003) (6)
- Evidence for monomeric metaphosphate as an intermediate in the hydrolysis of .mu.-monothiopyrophosphate (1991) (6)
- Steric Enhancement of Imidazole Basicity incis-Urocanic Acid Derivatives: Models for the Action of Chymotrypsin (1998) (6)
- pH‐Dependence in the Hydrolytic Action of the Human Fragile Histidine Triad (2005) (6)
- 5.09 – Radical Reactions Featuring Lysine 2,3-Aminomutase (1999) (6)
- S-adenosylmethionine and the mechanism of hydrogen transfer in the lysine 2,3-aminomutase reaction. (1987) (6)
- Isotope Effects in the Characterization of Low Barrier Hydrogen Bonds (2005) (6)
- UDPgalactose 4-epimerase catalyzed oxygen dependent reduction of a free radical substrate analogue by two electron reducing agents. (1976) (6)
- Standard free energies for uridylyl group transfer by hexose-1-P uridylyltransferase and UDP-hexose synthase and for the hydrolysis of uridine 5'-phosphoimidazolate. (1996) (6)
- Induced reoxidation and reactivation of a reduced uridine diphosphate galactose-4-epimerase complex. (1974) (5)
- Synthesis and Rearrangements of Alkyl Phosphorothioates (1985) (5)
- Probing interactions from solvent‐exchangeable protons and monovalent cations with the 1,2‐propanediol‐1‐yl radical intermediate in the reaction of dioldehydrase (2007) (5)
- p-(Bromoacetamido)phenyl uridyl pyrophosphate: an active-site-directed irreversible inhibitor for uridine diphosphate galactose 4-epimerase. (1979) (5)
- Sulfur as a mechanistic probe in enzymatic and non-enzymatic substitution at phosphorus (2010) (5)
- Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: an essential serine and a nonessential cysteine. (2000) (5)
- The substrate reactivity of mu-monothiopyrophosphate with pyrophosphate-dependent phosphofructokinase: evidence for a dissociative transition state in enzymatic phosphoryl group transfer. (1991) (5)
- Uridine diphosphate galactose 4-epimerase. Alkylation of enzyme-bound diphosphopyridine nucleotide by p-(bromoacetamido)phenyl uridyl pyrophosphate, an active-site-directed irreversible inhibitor. (1979) (5)
- A simplified procedure for synthesizing nucleoside 1-thiotriphosphates: dATP alpha S, dGTP alpha S, UTP alpha S, and dTTP alpha S. (1994) (4)
- Kinetic mechanism of UDP-hexose synthase, a point variant of hexose-1-phosphate uridylyltransferase from Escherichia coli. (1998) (4)
- Fundamentals of enzymology (Third Edition) (2001) (4)
- Stereochemistry of selected phosphotransferases and nucleotidyltransferases. (1982) (4)
- MECHANISM OF COUPLED ELECTRON AND GROUP TRANSFER IN Escherichia coli PYRUVATE DEHYDROGENASE * (1982) (4)
- Rate Enhancements Brought About by Uridine Nucleotides in the Reduction of NAD+ at the Active Site of UDP-Galactose 4-Epimerase☆☆☆ (2000) (4)
- Uridine Diphosphate Galactose 4-Epimerase (2001) (3)
- Reaction of wild-type C365S, and C458S saccharomyces cerevisiae phosphoenolpyruvate carboxykinases with fluorescent iodoacetamide derivatives. (1996) (3)
- The Roles of S‐Adenosylmethionine and Pyridoxal Phosphate in the Lysine 2,3‐Aminomutase Reaction a (1990) (3)
- Epimerization in the synthesis of thiophosphoanhydrides (1988) (3)
- Crystallization and preliminary crystallographic analysis of galactose-1-phosphate uridylyltransferase from Escherichia coli. (1994) (3)
- Interactions of metal ions with mu-monothiopyrophosphate. (1991) (3)
- Chemical Intermediates in Catalysis by Thiamine Diphosphate (2003) (2)
- Guidelines for writing research papers (2003) (2)
- Forging ahead: new mechanistic insights into iron biochemistry. (2011) (2)
- PHOSPHORUS-OXYGEN BOND ORDER IN ADENOSINE 5′-O-PHOSPHOROTHIOATE DIANION (1985) (2)
- Galactose-1-phosphate uridylyltransferase: kinetics of formation and reaction of uridylyl-enzyme intermediate in wild-type and specifically mutated uridylyltransferases. (2002) (2)
- Chemical Model for the Pyridoxal 5′-Phosphate Dependent Lysine Aminomutases. (1991) (2)
- Transient Intermediates in Enzymology, 1964–2008 (2015) (2)
- Mechanisms of enzymatic reactions : stereochemistry : proceedings of the Fifteenth Steenbock Symposium held June 30th through July 3rd, 1985 at the University of Wisconsin-Madison, U.S.A. (1986) (2)
- mu-Monothiopyrophosphate as a substrate for inorganic pyrophosphatase and UDP-glucose pyrophosphorylase. (1996) (1)
- CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-PHENYLALANINE TRIFLUOROMETHYL KETONE BOUND AT THE ACTIVE SITE (2000) (1)
- Free Radical Mechanisms in Enzymology (2006) (1)
- Facile hydrogen-deuterium exchange at the 5'-position of an analogue of S-adenosyl-l-methionine. (2002) (1)
- Snapshots of three intermediates at the active site of pyruvate oxidase (2006) (1)
- Surprises and revelations in biochemistry: 1950–2000 (2002) (1)
- Enzymatic and chemical reactivities of sym-monothiopyrophosphate (1991) (1)
- Abstracts, division of biological chemistry, 199th national meeting of the American chemical society, April 22-27, 1990 (1989) (1)
- Obituary: Robert H. Abeles (1926–2000) (2000) (1)
- Enzymology. Coenzymes and radicals. (2001) (1)
- Electron Spin Echo Envelope Modulation Spectroscopy Reveals How Adenosylcobalamin-Dependent Lysine 5,6-Aminomutase Positions the Radical Pair Intermediates and Modulates Their Stabilities for Efficient Catalysis (2021) (1)
- Pathways of Enzymatic Phosphotransfer Reactions (1987) (1)
- Functional and morphological studies of mitochondria exposed to undecagold clusters: biologic surfaces labeling with gold clusters. (1992) (1)
- DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI (1998) (1)
- Chemical spectroscopic and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli. (1992) (1)
- The Birth and Demise of Hypotheses on Evolution of S-Adenosyl-Lmethionineand Adenosylcobalamin (2017) (1)
- Structure and a Proposed Mechanism for Ornithine Cyclodeaminase from Pseudomonas putida (2004) (0)
- Prospects for Improvements in Biocatalysts for Large Scale Applications (1988) (0)
- Effect of Ion Pairing on Bond Order and Charge Localization in Alkyl Phosphorothioates. (1988) (0)
- Corrigendum to: Mutation Arg336 to Lys in Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase originates an enzyme with increased oxaloacetate decarboxylase activity (FEBS 24607) (2001) (0)
- CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-LEUCIL-PHENYLALANINE ALDEHYDE BOUND AT THE ACTIVE SITE (2000) (0)
- Correlation of Electronic Effects in N‐Alkylnicotinamides with NMR Chemical Shifts and Hydride Transfer Reactivity. (1996) (0)
- HAPTENTIC PROPERTIES OF PARALYTIC SHELLFISH POISON (1961) (0)
- Crystal structure of Lysine 5,6-Aminomutase in complex with PLP, cobalamin, and 5'-deoxyadenosine (2004) (0)
- Role of B12 coenzymes in the dioldehydrase reaction. (1966) (0)
- The role of iron-sulfur clusters, S-adenosylmethionine, and radicals in the reaction of lysine 2,3-aminomutase (1995) (0)
- ATP-Dependent Synthetases and Ligases (2007) (0)
- Synthesis of chiral [18O]phosphorothioate analogues of adenine nucleotides (1982) (0)
- ORITHINE CYCLODEAMINASE: STRUCTURE, MECHANISM OF ACTION, AND IMPLICATIONS FOR THE U-CRYSTALLIN FAMILY (2004) (0)
- THE STEREOCHEMISTRY OF CONVERSION OF PROPANEDIOL TO PROPIONALDHYDE. (1965) (0)
- Crystal Structure Analysis of Ornithine Cyclodeaminase Complexed with NAD and ornithine to 1.6 Angstroms (2004) (0)
- Enzymology Fundamentals of Enzymology: Rate Enhancement, Specificity, Control, and Applications Garfield P. Royer (1983) (0)
- UDP-GALACTOSE 4-EPIMERASE FROM ESCHERICHIA COLI, OXIDIZED (1996) (0)
- Low Barrier Hydrogen Bonds (2004) (0)
- A confluence of radical chemistry: S-Adenosylmethionine and Adenosylcob(III)alamin (2018) (0)
- Hiroshi Takeda and Osamu (2003) (0)
- Response : On Low-Barrier Hydrogen Bonds and Enzyme Catalysis (1995) (0)
- Studies on Es & e & ? & coli Pyruvate Dehydrogenase Complex (2003) (0)
- STEREOCHEMISTRY OF ENZYMIC REACTIONS OF PHOSPHATES (1982) (0)
- How are Vitamin B12 and S-Adenosylmethionine Related? (2021) (0)
- Low-Barrier Hydrogen Bonds (2013) (0)
- Proton nmr carbon 13 nmr and phosphorus 31 nmr of tobramycin tobramycin amp and tobramycin amps (1985) (0)
- Structural Basis for Radical Reaction Mechanisms in the Actions of Lysine Aminomutases (2007) (0)
- A Novel Mechanistic Role for Pyridoxal-5′-Phosphate (1991) (0)
- The structure of tetramethyl μ‐monothiopyrophosphate (1991) (0)
- Studies on the mechanism of action of uridine diphosphate-galactose-4-epimerase. I. An ambiguity in the chemical trapping of a proposed keto-intermediate by NaB-3H4. (1972) (0)
- Advances in research on metalloproteins. (2014) (0)
- Solvent effects on the solvolysis of ADPβS (1990) (0)
- S-Adenosylmethionine: A Wolf in Sheep′s Clothing, or a Rich Man′s Adenosylcobalamin? (2003) (0)
- 2.1 Angstrom X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale SB4, with Michaelis analog (L-alpha-lysine external aldimine form of pyridoxal-5'-phosphate). (2005) (0)
- Book Review:Biological Macromolecules and Assemblies. Volume 3: Active Sites of Enzymes. Frances A. Jurnak, Alexander McPherson (1988) (0)
- Synthesis of nucleoside [18O]pyrophosphorothioates with chiral [18O]phosphorothioate groups of known configuration. Stereochemical orientations of enzymatic phosphorylations of chiral [18O]phosphorothioates [22] (1979) (0)
- The Role of S‐Adenosylmethionine as a Poor Man's Adenosylcobalamin in the Reaction of Lysine 2,3‐Aminomutase (2007) (0)
- THE STRUCTURE OF NUCLEOTIDYLATED GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FROM ESCHERICHIA COLI AT 1.86 ANGSTROMS RESOLUTION (1997) (0)
- GENERAL DISCUSSION OF THIAMIN PYROPHOSPHATE‐REQUIRING ENZYMES (1982) (0)
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