Peter Carmeliet

Q: What Schools Are Affiliated With Peter Carmeliet

Peter Carmeliet is affiliated with the following schools: Vrije Universiteit Brussel, Heidelberg University, University of Amsterdam, University of Cincinnati, University of Tokyo, KU Leuven, University of Southern California, University of Toronto, Columbia University, Maastricht University, University of Vienna, University of Helsinki, Monash University, Aarhus University, McGill University, Sun Yat-sen University, University College London, Hebrew University of Jerusalem, Umeå University

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Peter Carmeliet

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#1252

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#2312

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#167

World Rank

#394

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Philosophy

Why Is Peter Carmeliet Influential?

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According to Wikipedia, Peter, Baron Carmeliet is a Belgian physician and professor at the Katholieke Universiteit Leuven . He is also Adjunct Director of the VIB Vesalius Research Center, KU Leuven. Among his research interests are vasculogenesis, angiogenesis, and vascular endothelial growth factor . In 2016, Carmeliet identified neuron-producing stem cells in the brain.

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Peter Carmeliet's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Angiogenesis in cancer and other diseases (2000) (8678)
Molecular mechanisms and clinical applications of angiogenesis (2011) (4433)
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele (1996) (4330)
Angiogenesis in health and disease (2003) (4188)
Mechanisms of angiogenesis and arteriogenesis (2000) (4175)
Angiogenesis in life, disease and medicine (2005) (3337)
Basic and Therapeutic Aspects of Angiogenesis (2011) (2265)
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (2183)
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001) (1669)
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011) (1385)
VEGF as a Key Mediator of Angiogenesis in Cancer (2005) (1383)
Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis (1999) (1346)
uPAR: a versatile signalling orchestrator (2002) (1234)
Physiological consequences of loss of plasminogen activator gene function in mice (1994) (1107)
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 (2002) (1099)
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration (2001) (1032)
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting (2013) (1013)
Molecular mechanisms of blood vessel growth. (2001) (1006)
Common mechanisms of nerve and blood vessel wiring (2005) (942)
Gene prioritization through genomic data fusion (2006) (924)
Hypoxia and inflammation. (2011) (903)
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death (2003) (881)
Phenotype molding of stromal cells in the lung tumor microenvironment (2018) (867)
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure (1999) (843)
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 (2003) (782)
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization (2009) (781)
Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels (2007) (778)
COVID-19: the vasculature unleashed (2020) (739)
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization (1998) (728)
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. (2004) (728)
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 (1999) (725)
Role of tissue factor in embryonic blood vessel development (1996) (721)
The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling (2001) (701)
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation (1997) (698)
Molecular mechanisms of lymphangiogenesis in health and disease. (2002) (675)
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase (2020) (674)
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (2011) (641)
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model (2004) (608)
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998) (1998) (579)
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. (2002) (556)
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? (2008) (551)
Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects (2001) (547)
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system (2004) (532)
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. (2013) (528)
Modification of kidney barrier function by the urokinase receptor (2008) (524)
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice (2002) (523)
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS (2005) (516)
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection (2004) (504)
Blood vessels and nerves: common signals, pathways and diseases (2003) (503)
Single-Cell Transcriptome Atlas of Murine Endothelial Cells (2020) (495)
Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling (2011) (491)
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (2008) (482)
Protective Role of Reactive Astrocytes in Brain Ischemia (2008) (471)
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice (2002) (466)
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis (2001) (452)
Tumor hypoxia causes DNA hypermethylation by reducing TET activity (2016) (445)
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 (2000) (441)
A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours (2011) (429)
Fatty acid carbon is essential for dNTP synthesis in endothelial cells (2015) (425)
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. (2005) (419)
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. (1993) (417)
Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. (2009) (411)
VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells (2006) (409)
Conditional switching of VEGF provides new insights into adult neovascularization and pro‐angiogenic therapy (2002) (400)
Endothelial cell metabolism in normal and diseased vasculature. (2015) (397)
Role and therapeutic potential of VEGF in the nervous system. (2009) (396)
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. (2014) (396)
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy (2001) (394)
FOXO1 couples metabolic activity and growth state in the vascular endothelium (2015) (393)
PR39, a peptide regulator of angiogenesis (2000) (390)
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. (2016) (379)
Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. (1995) (376)
VEGF gene therapy: stimulating angiogenesis or angioma-genesis? (2000) (375)
Regulation of angiogenesis by oxygen and metabolism. (2009) (370)
Consensus guidelines for the use and interpretation of angiogenesis assays (2018) (370)
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival (2008) (367)
Metabolism of stromal and immune cells in health and disease (2014) (367)
Mechanisms of Vessel Branching: Filopodia on Endothelial Tip Cells Lead the Way (2009) (360)
Placental growth factor and its receptor, vascular endothelial growth factor receptor‐1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders (2003) (357)
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. (1993) (351)
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling (2004) (350)
VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization (2006) (347)
Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3 (2000) (338)
VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic: Evidence for a Monocyte-Mediated Mechanism (2003) (338)
The Plasminogen Activator Inhibitor PAI-1 Controls In Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies (2001) (337)
Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. (1996) (337)
Tumor vessel normalization by chloroquine independent of autophagy. (2014) (336)
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. (2014) (330)
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. (2003) (324)
Neurovascular signalling defects in neurodegeneration (2008) (313)
Markers of response for the antiangiogenic agent bevacizumab. (2013) (312)
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis. (2016) (312)
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease (2009) (309)
Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth (2004) (308)
VEGF: A modifier of the del22q11 (DiGeorge) syndrome? (2003) (307)
Role of endothelial cell metabolism in vessel sprouting. (2013) (305)
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. (2003) (299)
Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer (2004) (292)
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. (2006) (288)
Endothelial Cell Metabolism. (2018) (282)
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy (2001) (282)
The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent (2002) (282)
Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. (1989) (281)
Increased Cardiac Expression of Tissue Inhibitor of Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-2 Is Related to Cardiac Fibrosis and Dysfunction in the Chronic Pressure-Overloaded Human Heart (2005) (279)
Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. (2013) (274)
The FGF system has a key role in regulating vascular integrity. (2008) (274)
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration (2008) (274)
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? (2011) (274)
Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. (1996) (274)
Molecular Basis of Angiogenesis: Role of VEGF and VE‐Cadherin (2000) (273)
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. (2000) (269)
Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. (1997) (269)
Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. (2004) (266)
Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease (2010) (265)
Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. (2010) (264)
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. (2005) (263)
Oxygen sensors at the crossroad of metabolism. (2009) (262)
Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats (2007) (261)
Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality (2006) (260)
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. (2008) (258)
Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. (1998) (252)
Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. (2002) (249)
A mouse model for Zellweger syndrome (1997) (248)
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome (2001) (247)
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. (2010) (244)
Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. (1997) (243)
VEGF: a critical player in neurodegeneration. (2004) (238)
A genetic Xenopus laevis tadpole model to study lymphangiogenesis (2005) (236)
Generation and characterization of urokinase receptor-deficient mice. (1996) (236)
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. (2001) (235)
TRPA1 underlies a sensing mechanism for O2. (2011) (235)
The Neurovascular Link in Health and Disease: Molecular Mechanisms and Therapeutic Implications (2011) (234)
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome. (2016) (233)
Mice lacking factor VII develop normally but suffer fatal perinatal bleeding (1997) (232)
Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. (1998) (229)
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. (2008) (229)
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice (2002) (227)
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. (2018) (223)
Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. (1998) (223)
Vascular wound healing and neointima formation induced by perivascular electric injury in mice. (1997) (221)
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. (2008) (219)
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. (2007) (217)
Vascular progenitors: from biology to treatment. (2002) (215)
Low levels of tissue factor are compatible with development and hemostasis in mice. (1998) (215)
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity (2007) (214)
Urokinase Receptor Is Necessary for Adequate Host Defense Against Pneumococcal Pneumonia1 (2002) (213)
Vascular endothelial growth factor: a neurovascular target in neurological diseases (2016) (213)
Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. (1999) (211)
Impaired arterial neointima formation in mice with disruption of the plasminogen gene. (1997) (211)
Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way (2009) (211)
Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma (2013) (209)
FGF-dependent metabolic control of vascular development (2017) (207)
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice (2008) (206)
Manipulating angiogenesis in medicine (2004) (205)
Intestinal Calcium Transporter Genes Are Upregulated by Estrogens and the Reproductive Cycle Through Vitamin D Receptor‐Independent Mechanisms (2003) (203)
The Link Between Angiogenesis and Endothelial Metabolism. (2017) (202)
Plasminogen and Plasminogen Activators Protect against Renal Injury in Crescentic Glomerulonephritis (1997) (202)
Inactivation of the Peroxisomal Multifunctional Protein-2 in Mice Impedes the Degradation of Not Only 2-Methyl-branched Fatty Acids and Bile Acid Intermediates but Also of Very Long Chain Fatty Acids* (2000) (202)
Overlap Syndrome of Cardiac Sodium Channel Disease in Mice Carrying the Equivalent Mutation of Human SCN5A-1795insD (2006) (198)
Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system. (1998) (197)
The role of fatty acid β-oxidation in lymphangiogenesis (2016) (197)
Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. (1999) (195)
Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development. (1999) (193)
Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. (1998) (193)
The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation (2008) (193)
Genetic evidence for a tumor suppressor role of HIF-2alpha. (2005) (192)
Guidance of vascular and neural network formation (2005) (191)
Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation (2005) (189)
Increased skeletal VEGF enhances β‐catenin activity and results in excessively ossified bones (2010) (188)
Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways. (2015) (188)
Hallmarks of Endothelial Cell Metabolism in Health and Disease. (2019) (188)
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. (2003) (188)
Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1) (2002) (188)
A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity (2017) (187)
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. (2010) (187)
A critical role of placental growth factor in the induction of inflammation and edema formation. (2003) (186)
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. (2012) (184)
Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction (2009) (182)
Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms (2009) (181)
Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications. (2011) (180)
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. (2011) (180)
Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. (1998) (180)
PlGF: a multitasking cytokine with disease-restricted activity. (2012) (179)
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. (2013) (176)
Loss of the Cholesterol-Binding Protein Prominin-1/CD133 Causes Disk Dysmorphogenesis and Photoreceptor Degeneration (2009) (175)
MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis (2012) (173)
Endothelial Cell Metabolism in Health and Disease. (2017) (170)
Role of glutamine and interlinked asparagine metabolism in vessel formation (2017) (169)
Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? (2003) (168)
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain (2006) (166)
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. (2020) (165)
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. (2010) (164)
Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth (2004) (161)
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. (2005) (160)
Blood Coagulation Factor X Deficiency Causes Partial Embryonic Lethality and Fatal Neonatal Bleeding in Mice (2000) (160)
Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. (2005) (159)
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. (2008) (157)
Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. (2003) (157)
Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. (2000) (156)
Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease (2014) (154)
Endothelial cell metabolism in health and disease: impact of hypoxia (2017) (152)
VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis (2003) (152)
Heterogeneous vascular dependence of tumor cell populations. (2001) (151)
Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. (2006) (151)
Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences (2004) (150)
Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and Macrophage Accumulation (2005) (149)
Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin II–Induced Abdominal Aortic Aneurysm (2003) (149)
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis (2016) (148)
Transgenic mouse models in angiogenesis and cardiovascular disease (2000) (147)
New perspectives in the function of pituitary folliculo-stellate cells (1990) (146)
The Emerging Role of the Bone Marrow-Derived Stem Cells in (Therapeutic) Angiogenesis (2001) (146)
Selective regulation of arterial branching morphogenesis by synectin. (2006) (146)
Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. (2007) (145)
Receptor-independent Role of Urokinase-Type Plasminogen Activator in Pericellular Plasmin and Matrix Metalloproteinase Proteolysis during Vascular Wound Healing in Mice (1998) (141)
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2 (2017) (141)
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. (2007) (141)
Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. (2002) (141)
Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation (2010) (141)
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 (2011) (139)
The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling. (2017) (138)
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis. (2018) (138)
Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. (2000) (136)
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration (2013) (135)
3D systems delivering VEGF to promote angiogenesis for tissue engineering. (2011) (135)
Molecular analysis of blood vessel formation and disease. (1997) (134)
Lack of Plasminogen Activator Inhibitor-1 Promotes Growth and Abnormal Matrix Remodeling of Advanced Atherosclerotic Plaques in Apolipoprotein E–Deficient Mice (2002) (134)
Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis. (1998) (131)
Basic and Therapeutic Aspects of Angiogenesis Updated. (2020) (131)
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. (2011) (130)
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. (2010) (130)
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. (2013) (130)
Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences (2009) (129)
Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis (2002) (129)
Insights in Vessel Development and Vascular Disorders Using Targeted Inactivation and Transfer of Vascular Endothelial Growth Factor, the Tissue Factor Receptor, and the Plasminogen System (1997) (129)
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization (2020) (128)
Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish (2010) (128)
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes (2019) (128)
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. (2013) (127)
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. (1999) (127)
Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo. (2001) (125)
SnapShot: Tumor Angiogenesis (2012) (124)
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. (2012) (122)
The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress (2008) (121)
Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR. (2004) (121)
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. (2018) (120)
The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses. (2014) (120)
Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators. (1995) (120)
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. (2020) (118)
Novel Role for Vascular Endothelial Growth Factor (VEGF) Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration (2008) (117)
INCREASED EXPRESSION OF SYNDECAN-1 PROTECTS AGAINST CARDIAC DILATATION AND DYSFUNCTION AFTER MYOCARDIAL INFARCTION.: PH.5 (2005) (117)
Modeling lymphangiogenesis in a three-dimensional culture system (2008) (117)
Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration (2004) (116)
Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models (2011) (114)
Vascular development and disorders: molecular analysis and pathogenic insights. (1998) (114)
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. (1999) (114)
Genetic Deletion of Placenta Growth Factor in Mice Alters Uterine NK Cells (2007) (113)
Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. (2003) (113)
Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium (2008) (112)
Glycolytic regulation of cell rearrangement in angiogenesis (2016) (112)
Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. (2002) (112)
Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. (2007) (111)
HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. (2016) (111)
Reduced transplant arteriosclerosis in plasminogen-deficient mice. (1998) (110)
Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-Induced Demyelination (2008) (110)
Tissue factor expression during human and mouse development. (1996) (109)
Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1α-independent translation-mediated mechanism. (2014) (108)
Lessons from the adjuvant bevacizumab trial on colon cancer: what next? (2011) (107)
A Novel Role for Vascular Endothelial Growth Factor as an Autocrine Survival Factor for Embryonic Stem Cells during Hypoxia* (2005) (107)
Inhibition of Urokinase-Type Plasminogen Activator or Matrix Metalloproteinases Prevents Cardiac Injury and Dysfunction During Viral Myocarditis (2006) (107)
Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. (2002) (105)
Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia* (2001) (105)
Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia. (2003) (104)
Replacement of the Muscle-Specific Sarcoplasmic Reticulum Ca2+-ATPase Isoform SERCA2a by the Nonmuscle SERCA2b Homologue Causes Mild Concentric Hypertrophy and Impairs Contraction-Relaxation of the Heart (2001) (104)
Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. (2003) (104)
The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment (2008) (103)
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction (2002) (103)
Vessels of death or life. (2001) (103)
VEGF at the neurovascular interface: therapeutic implications for motor neuron disease. (2006) (103)
De novo vasculogenesis in the heart. (2003) (103)
Interferon-gamma inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures. (1990) (102)
Cell Type‐Specific Expression of Neuropilins in an MCA‐Occlusion Model in Mice Suggests a Potential Role in Post‐Ischemic Brain Remodeling (2002) (101)
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. (2001) (99)
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis (2018) (99)
Engineering Vascularized Bone: Osteogenic and Proangiogenic Potential of Murine Periosteal Cells (2012) (99)
Blood-vessel formation: Bridges that guide and unite (2010) (99)
Endothelial cell metabolism: parallels and divergences with cancer cell metabolism (2014) (98)
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. (2013) (98)
Principles and therapeutic implications of angiogenesis, vasculogenesis and arteriogenesis. (2006) (98)
Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization (2010) (98)
PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity (2016) (98)
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. (2018) (97)
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis (2017) (97)
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. (2015) (97)
Role of neural guidance signals in blood vessel navigation. (2005) (96)
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. (2001) (96)
Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy (2009) (96)
Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds. (2015) (95)
Erratum: Corrigendum: The European dimension for the mouse genome mutagenesis program (2004) (95)
correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (94)
Implication of the hypoxia response element of the vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development (2006) (94)
Role of Gas6 in erythropoiesis and anemia in mice. (2008) (92)
Functional Reprogramming of Regulatory T cells in the absence of Foxp3 (2018) (92)
Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism (2011) (91)
Loss of placental growth factor protects mice against vascular permeability in pathological conditions. (2002) (90)
Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism. (2003) (90)
Angiogenesis Revisited: An Overlooked Role of Endothelial Cell Metabolism in Vessel Sprouting (2015) (90)
G Protein–Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway (2009) (89)
PAR1 contributes to influenza A virus pathogenicity in mice. (2013) (88)
Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism (2013) (88)
Lipid availability determines skeletal progenitor cell fate via SOX9 (2020) (88)
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. (2006) (87)
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. (2018) (87)
Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche. (2011) (86)
Cerebrovascular disorders: molecular insights and therapeutic opportunities (2011) (85)
Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. (2005) (85)
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (2013) (84)
Growing better blood vessels (2001) (84)
Polyoma Middle T-induced Vascular Tumor Formation: The Role of the Plasminogen Activator/Plasmin System (1997) (84)
Cell-to-cell communication in peptide target cells of anterior pituitary. (1989) (83)
Biological Effects of Disruption of the Tissue‐Type Plasminogen Activator, Urokinase‐Type Plasminogen Activator, and Plasminogen Activator Inhibitor‐1 Genes in Mice a (1994) (82)
Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. (2003) (82)
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the −2578AA genotype (2008) (82)
Clotting Factors Build Blood Vessels (2001) (82)
Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells (2017) (82)
Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis (2012) (81)
Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism (2017) (81)
The genesis of the third and fourth heart sounds. A pressure-flow study in dogs. (1984) (80)
Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase. (2012) (80)
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin (2014) (80)
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin (2018) (80)
Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice (2011) (80)
Pericytes: Blood-Brain Barrier Safeguards against Neurodegeneration? (2010) (79)
Matrix-Binding Vascular Endothelial Growth Factor (VEGF) Isoforms Guide Granule Cell Migration in the Cerebellum via VEGF Receptor Flk1 (2010) (79)
Smad3-Dependent Induction of Plasminogen Activator Inhibitor-1 in Astrocytes Mediates Neuroprotective Activity of Transforming Growth Factor-β1 against NMDA-Induced Necrosis (2002) (78)
Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake (2015) (78)
Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism (2014) (78)
Allosteric targeting of receptor tyrosine kinases (2014) (78)
How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors (2017) (78)
Angiogenesis: a target in solid tumors, also in leukemia? (2011) (77)
An SDF-1 Trap for Myeloid Cells Stimulates Angiogenesis (2006) (77)
Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium (2001) (77)
Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. (2003) (77)
Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System (1995) (77)
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation (2018) (77)
Oxygen-Induced Retinopathy in Mice: Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration (2009) (76)
Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets? (2004) (76)
Urokinase and Tissue-type Plasminogen Activator Are Required for the Mitogenic and Chemotactic Effects of Bovine Fibroblast Growth Factor and Platelet-derived Growth Factor-BB for Vascular Smooth Muscle Cells* (1997) (75)
Novel pore mutation in SCN5A manifests as a spectrum of phenotypes ranging from atrial flutter, conduction disease, and Brugada syndrome to sudden cardiac death. (2004) (75)
Protein kinase D2 is a crucial regulator of tumour cell–endothelial cell communication in gastrointestinal tumours (2010) (75)
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity (2017) (74)
Placental growth factor mediates aldosterone-dependent vascular injury in mice. (2010) (74)
MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells (2012) (74)
Developmental biology: One cell, two fates (2000) (73)
Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma? (2013) (73)
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models (2013) (72)
Macrophage-derived glutamine boosts satellite cells and muscle regeneration (2020) (72)
Plasminogen Controls Inflammation and Pathogenesis of Influenza Virus Infections via Fibrinolysis (2013) (72)
Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity. (2004) (72)
Tumor vessel disintegration by maximum tolerable PFKFB3 blockade (2017) (72)
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. (2010) (72)
CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions (2017) (71)
The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: Insights from genetic studies (2000) (71)
Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A. (2000) (70)
Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities. (2016) (70)
The neurovascular link in health and disease: an update. (2009) (70)
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. (2001) (70)
Similarities between angiogenesis and neural development: what small animal models can tell us. (2008) (70)
Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease. (2005) (69)
Hepatocyte Growth Factor Acts as a Motogen and Guidance Signal for Gonadotropin Hormone-Releasing Hormone-1 Neuronal Migration (2007) (69)
Regulation and cellular localization of the membrane-bound thyrotropin-releasing hormone-degrading enzyme in primary cultures of neuronal, glial and adenohypophyseal cells. (1990) (69)
Temporal and Topographic Matrix Metalloproteinase Expression after Vascular Injury in Mice (1999) (68)
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (2019) (68)
Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. (2003) (68)
Developmental biology: Controlling the cellular brakes (1999) (68)
Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study (2005) (68)
The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts. (2015) (68)
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation. (2019) (68)
Blockade of Myeloid-Derived Suppressor Cell Expansion with All-Trans Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy. (2018) (68)
Gene manipulation and transfer of the plasminogen and coagulation system in mice. (1996) (67)
Gene targeting and gene transfer studies of the plaeminogen/plasmin system: implications in thrombosis, hemostasis, neointima formation, and atherosclerosis (1995) (67)
Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. (2016) (67)
Impaired adipose tissue development in mice with inactivation of placental growth factor function. (2006) (67)
Plasmin is not protective in experimental renal interstitial fibrosis. (2004) (66)
Testosterone Suppresses Protective Responses of the Liver to Blood-Stage Malaria (2005) (66)
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity (2020) (66)
Development of targeted angiogenic medicine (2009) (65)
Prominin-1 Allows Prospective Isolation of Neural Stem Cells from the Adult Murine Hippocampus (2013) (65)
Metabolic pathway compartmentalization: an underappreciated opportunity? (2015) (65)
Plasminogen Activator Inhibitor 1 and Vitronectin Protect Against Stenosis in a Murine Carotid Artery Ligation Model (2002) (65)
Meta‐analysis of clinical metabolic profiling studies in cancer: challenges and opportunities (2016) (65)
Placental growth factor in cancer (2014) (65)
Deficiency of Urokinase-Type Plasminogen Activator–Mediated Plasmin Generation Impairs Vascular Remodeling During Hypoxia-Induced Pulmonary Hypertension in Mice (2001) (64)
Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis (2008) (64)
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (64)
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. (2009) (64)
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3 (2010) (64)
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. (2005) (64)
Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning. (2013) (64)
Tetralogy of Fallot and Alterations in Vascular Endothelial Growth Factor-A Signaling and Notch Signaling in Mouse Embryos Solely Expressing the VEGF120 Isoform (2007) (63)
Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin (2011) (63)
Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. (2016) (63)
NuSAP is essential for chromatin-induced spindle formation during early embryogenesis (2010) (63)
Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. (2003) (63)
Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. (2003) (63)
From Vessel Sprouting to Normalization: Role of the Prolyl Hydroxylase Domain Protein/Hypoxia-Inducible Factor Oxygen-Sensing Machinery (2010) (62)
The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis (2004) (62)
The diversity of endothelial cells: a challenge for therapeutic angiogenesis (2004) (62)
“Antimyeloangiogenic” Therapy for Cancer by Inhibiting PlGF (2009) (62)
Receptor‐independent role of the urokinase‐type plasminogen activator during arteriogenesis (2003) (62)
Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis. (2006) (62)
Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism (2019) (62)
Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension. (2009) (62)
Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: a goal for therapeutic angiogenesis? (2000) (62)
Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms (2007) (61)
PlGF Repairs Myocardial Ischemia through Mechanisms of Angiogenesis, Cardioprotection and Recruitment of Myo-Angiogenic Competent Marrow Progenitors (2011) (61)
Lymph makes you fat (2005) (61)
Targeting fatty acid metabolism in cancer and endothelial cells. (2016) (60)
Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation. (2015) (60)
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles. (2008) (60)
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets (2018) (59)
Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) -/- mice. (2003) (59)
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism (2017) (59)
Molecules in focus Tissue factor (1998) (59)
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. (2013) (59)
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. (2019) (59)
Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance (2013) (59)
Metabolic Pathways Fueling the Endothelial Cell Drive. (2019) (59)
Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis (2008) (58)
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. (2017) (58)
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines (2020) (58)
Metabolic control of the cell cycle (2015) (58)
Neuronal Migration Depends on Intact Peroxisomal Function in Brain and in Extraneuronal Tissues (2003) (58)
Endogenous Tissue-Type Plasminogen Activator Is Protective during Escherichia coli-Induced Abdominal Sepsis in Mice1 (2006) (58)
Object-based attention determines dominance in binocular rivalry (58)
Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. (2001) (57)
Altered Na+ Channels Promote Pause-Induced Spontaneous Diastolic Activity in Long QT Syndrome Type 3 Myocytes (2006) (56)
FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish. (2011) (56)
Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells. (2012) (56)
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways. (2015) (56)
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR (2014) (56)
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit. (1999) (56)
Neonatal hypoxic preconditioning involves vascular endothelial growth factor (2007) (55)
Central Role of Metabolism in Endothelial Cell Function and Vascular Disease. (2017) (55)
Lipid availability determines fate of skeletal progenitor cells via SOX9 (2020) (55)
Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization. (2003) (55)
Control of vessel sprouting by genetic and metabolic determinants (2013) (54)
The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury (2005) (54)
Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. (2012) (54)
Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. (2003) (54)
Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through overactivation of transforming growth factor β (2003) (54)
Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy. (2012) (52)
Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin. (1991) (52)
De novo design of a biologically active amyloid (2016) (51)
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. (2003) (51)
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. (2010) (51)
Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis (2002) (51)
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. (2006) (51)
Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties (2010) (51)
Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation. (2010) (50)
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations (2018) (50)
Proteinases in cardiovascular aneurysms and rupture: targets for therapy? (2000) (50)
EndoDB: a database of endothelial cell transcriptomics data (2018) (50)
uPA deficiency exacerbates muscular dystrophy in MDX mice (2007) (49)
Synthesis and release of acetylcholine by normal and tumoral pituitary corticotrophs. (1989) (49)
Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies (2013) (49)
The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. (2003) (49)
Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. (2010) (49)
The metabolic engine of endothelial cells (2019) (48)
Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner. (2005) (47)
Evolution of Oxygen and Glucose Concentration Profiles in a Tissue-Mimetic Culture System of Embryonic Stem Cells (2006) (47)
Role of plasminogen system components in focal cerebral ischemia (1999) (47)
Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development. (2018) (47)
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells (2013) (47)
VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS? (2004) (47)
Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation (2013) (47)
Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. (2011) (47)
Incomplete and transitory decrease of glycolysis (2014) (47)
Molecular analysis of blood vessel formation and disease. (1997) (47)
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis (2020) (46)
Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques (2006) (46)
Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice. (2004) (46)
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity (2021) (46)
Genetic analysis of blood vessel formation role of endothelial versus smooth muscle cells. (1997) (45)
Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials. (2003) (45)
Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction (2017) (45)
Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective? (2016) (45)
Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary. (1988) (45)
Metabolism and therapeutic angiogenesis. (2008) (45)
Immunomodulation by endothelial cells — partnering up with the immune system? (2022) (45)
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A (2016) (45)
Homeostasis and transitional activation of regulatory T cells require c-Myc (2020) (45)
Plasminogen and cell migration in vivo (1999) (44)
Neuronal FLT1 receptor and its selective ligand VEGF‐B protect against retrograde degeneration of sensory neurons (2011) (44)
Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system. (2003) (44)
VEGF‐D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis (2009) (44)
Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. (2008) (44)
Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy (2014) (44)
Placental growth factor deficiency is associated with impaired cerebral vascular development in mice. (2016) (44)
The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis (2015) (44)
Immaturity of microvessels in haemorrhagic plaques is associated with proteolytic degradation of angiogenic factors. (2010) (44)
Elevated levels of placental growth factor represent an adaptive host response in sepsis (2008) (43)
Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. (2011) (43)
The Zebrafish pob Gene Encodes a Novel Protein Required for Survival of Red Cone Photoreceptor Cells Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession no. AY745978. (2005) (43)
Beneficial effects of prolonged systemic administration of PlGF on late outcome of post‐ischaemic myocardial performance (2008) (42)
The NADPH oxidase Nox2 regulates VEGFR1/CSF‐1R‐mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex (2013) (42)
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. (2016) (41)
Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. (2011) (41)
Genetic analysis of the plasminogen and coagulation system in mice. (1996) (41)
Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function (2006) (41)
Role of synectin in lymphatic development in zebrafish and frogs. (2010) (41)
Tissue-Type Plasminogen Activator Deficiency Exacerbates Arthritis1 (2001) (41)
Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression* (2011) (41)
Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells (2009) (40)
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination (2007) (40)
Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin (2012) (40)
Vessel pruning or healing: endothelial metabolism as a novel target? (2017) (40)
Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective. (2017) (40)
HIF1 Activity in Granulosa Cells Is Required for FSH-Regulated Vegfa Expression and Follicle Survival in Mice1 (2014) (40)
804 ORAL Evaluation of Plasma VEGFA as a Potential Predictive Pan-tumour Biomarker for Bevacizumab (2011) (40)
PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7 (2013) (40)
Molecular genetics of the fibrinolytic and coagulation systems in haemostasis, thrombogenesis, restenosis and atherosclerosis. (1997) (40)
Bevacizumab and micrometastases: revisiting the preclinical and clinical rollercoaster. (2014) (40)
Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics (2018) (40)
How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development. (2017) (40)
Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord. (2014) (40)
Novel Mutation in the Per-Arnt-Sim Domain of KCNH2 Causes a Malignant Form of Long-QT Syndrome (2005) (39)
Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium. (2019) (39)
A surrogate marker to monitor angiogenesis at last. (2005) (39)
Metabolic adaptations in diabetic endothelial cells. (2015) (39)
Generation of Monoclonal Antibodies against Autologous Proteins in Gene-inactivated Mice (*) (1995) (39)
Ovulation in plasminogen-deficient mice. (1999) (39)
Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease (2007) (39)
Plasminogen mediates liver regeneration and angiogenesis after experimental partial hepatectomy (2003) (38)
PIGF Knockout Delays Brain Vessel Growth and Maturation upon Systemic Hypoxic Challenge (2012) (38)
Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis (2019) (38)
Evaluation of the plasminogen/plasmin system in transgenic mice (1994) (38)
A key role for transketolase-like 1 in tumor metabolic reprogramming (2016) (38)
Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator. (2005) (38)
Role of the plasminogen/plasmin system in thrombosis, hemostasis, restenosis and atherosclerosis evaluation in transgenic animals. (1995) (38)
Integrin indecision (2002) (38)
A Role of Plasminogen in Atherosclerosis and Restenosis Models in Mice (1999) (37)
Plasminogen Activator Inhibitor-1 Regulates Integrin αvβ3 Expression and Autocrine Transforming Growth Factor β Signaling* (2009) (37)
Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery (2010) (37)
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. (2020) (37)
Targeted gene manipulation and transfer of the plasminogen and coagulation systems in mice (1996) (36)
Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development. (1999) (36)
Plasminogen is not required for neointima formation in a mouse model of vein graft stenosis. (1999) (36)
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. (2010) (36)
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis (2010) (36)
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation (2011) (36)
Notch3 Arg170Cys Knock-In Mice Display Pathologic and Clinical Features of the Neurovascular Disorder Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (2011) (36)
Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration. (2016) (36)
Plasmin therapy enhances mobilization of HPCs after G-CSF. (2008) (36)
Involvement of placental growth factor in Wallerian degeneration (2011) (35)
Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF. (2004) (35)
The pathophysiology of pelvic floor disorders: evidence from a histomorphologic study of the perineum and a mouse model of rectal prolapse (2001) (35)
Tissue plasminogen activator arrests Alzheimer's disease pathogenesis (2014) (35)
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor–Sensitive and -Resistant Chronic Myeloid Leukemia (2016) (35)
BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization (2020) (35)
Life-Threatening Thrombosis in Mice With Targeted Arg48-to-Cys Mutation of the Heparin-Binding Domain of Antithrombin (2003) (34)
The Nuclear Scaffold Protein NIPP1 Is Essential for Early Embryonic Development and Cell Proliferation (2004) (34)
Phenotypic diversity and metabolic specialization of renal endothelial cells (2021) (34)
Paracrine control of vascular innervation in health and disease (2011) (34)
Neuroprotection by urokinase plasminogen activator in the hippocampus (2012) (34)
Successful double-lung transplantation from a donor previously infected with SARS-CoV-2 (2020) (34)
Improved metabolite identification with MIDAS and MAGMa through MS/MS spectral dataset-driven parameter optimization (2016) (33)
Another angiogenic gene linked to amyotrophic lateral sclerosis. (2006) (33)
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis (2012) (33)
Role of Gas-6 in Adipogenesis and Nutritionally Induced Adipose Tissue Development in Mice (2005) (33)
Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications (2005) (33)
Cardiovascular biology: Creating unique blood vessels (2001) (33)
uPA deficiency exacerbates muscular dystrophy in MDX mice (2007) (33)
Tumor vessel co-option probed by single-cell analysis. (2021) (32)
Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury (2010) (32)
Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling (2017) (32)
Sculpting Heart Valves with NFATc and VEGF (2004) (32)
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth (2019) (32)
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. (2015) (32)
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism (2019) (31)
Metabolic Signatures of Distinct Endothelial Phenotypes (2020) (31)
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance (2020) (31)
Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice (2018) (31)
Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity. (2014) (30)
Impact of placental growth factor deficiency on early mouse implant site angiogenesis. (2014) (30)
Glutamine Metabolism Controls Chondrocyte Identity and Function. (2020) (30)
Adenovirus-Mediated Transfer of Tissue-Type Plasminogen Activator Augments Thrombolysis in Tissue-Type Plasminogen Activator–Deficient and Plasminogen Activator Inhibitor-1–Overexpressing Mice (1997) (30)
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis (2022) (30)
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma (2016) (29)
VEGFR‐2‐mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes (2008) (29)
Haematopoietic prolyl hydroxylase‐1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis (2017) (29)
Generation of Pex5‐loxP mice allowing the conditional elimination of peroxisomes (2002) (29)
Modification of K channel inactivation by papain and N-bromoacetamide. (1988) (29)
Matrix deformations around angiogenic sprouts correlate to sprout dynamics and suggest pulling activity (2020) (29)
Prevention of elastase-induced emphysema in placenta growth factor knock-out mice (2009) (29)
Vascular Remodeling in Mice Lacking the Cytoplasmic Domain of Tissue Factor (2005) (28)
Involvement of u‐PA in the anti‐apoptotic activity of TGFβ for vascular smooth muscle cells (1997) (28)
Ovulation in Plasminogen-Deficient Mice1. (1999) (28)
Targeting angiogenic metabolism in disease (2018) (28)
A New Mouse Model to Study Acquired Lymphedema (2006) (28)
Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH‐Induced Bone Anabolism in Male Mice (2020) (28)
Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy (2005) (27)
Plasminogen Deficiency Differentially Affects Recruitment of Inflammatory Cell Populations in Mice (1998) (27)
Endothelial Metabolism Driving Angiogenesis: Emerging Concepts and Principles (2015) (27)
Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection (2012) (27)
Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow (2016) (27)
Oxygen sensing: a common crossroad in cancer and neurodegeneration. (2010) (27)
IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo (2019) (27)
Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature (2015) (27)
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF 23 production in osteoblasts (2006) (27)
Author Correction: COVID-19: the vasculature unleashed (2020) (26)
Endothelial cell plasticity at the single-cell level (2021) (26)
Genetic markers of bevacizumab-induced hypertension (2014) (26)
Stem cell marker prominin‐1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland (2011) (26)
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner. (2016) (26)
Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice. (2004) (25)
Stromal Gas6 promotes the progression of premalignant mammary cells (2018) (25)
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation (2008) (25)
PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. (2017) (25)
NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye1 (2007) (25)
Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency. (1997) (24)
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis (2020) (24)
Sex‐specific, reciprocal regulation of ERα and miR‐22 controls muscle lipid metabolism in male mice (2017) (23)
Characterization of a cDNA Encoding Murine Coagulation Factor VII (1996) (23)
PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production (2019) (23)
Renal cyst formation in Fh 1-deficient mice is independent of the Hif / Phd pathway (2011) (23)
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model. (2013) (23)
VEGF Receptor-2 (Flk-1) Overexpression in Mice Counteracts Focal Epileptic Seizures (2012) (23)
High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate (2013) (23)
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice. (2012) (22)
Alzheimer's disease: A breach in the blood–brain barrier (2012) (22)
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen (1996) (22)
Roles of urokinase type plasminogen activator in a brain stab wound (2000) (21)
Biological Effects of Combined Inactivation of Plasminogen Activator and Plasminogen Activator Inhibitor-1 Gene Function in Mice (1995) (21)
Nucleotide Structure and Characterization of the Murine Blood Coagulation Factor VII Gene (1996) (21)
Gas6 protein: its role in cardiovascular calcification (2016) (20)
Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (2015) (20)
Transgenic tissue‐type plasminogen activator expression improves host defense during Klebsiella pneumonia (2008) (20)
Angiogenesis and lymphangiogenesis: highlights of the past year (2004) (20)
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression. (2016) (20)
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen. (1996) (20)
Vascular Endothelial Growth Factor Up-regulation in Human Amniotic Fluid Stem Cell Enhances Nephroprotection After Ischemia-Reperfusion Injury in the Rat (2017) (20)
Hypoxia-inducible factor-1α-dependent induction of miR122 enhances hepatic ischemia tolerance. (2021) (19)
Fishing and frogging for anti-angiogenic drugs (2006) (19)
Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma. (2012) (19)
Analyzing cell-type-specific dynamics of metabolism in kidney repair (2022) (19)
Drug discovery: A lifeline for suffocating tissues (2008) (19)
Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19 (2021) (18)
Stimulation and inhibition of prolactin release from rat pituitary lactotrophs by the cholinomimetic carbachol in vitro. Influence of hormonal environment and intercellular contacts (1989) (18)
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension (2021) (18)
Interleukin-1β inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20 (1989) (18)
Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone. (2012) (18)
Bone marrow transplantation rescues infarct healing, whereas vascular endothelial growth factor fails to increase angiogenesis in urokinase deficient mice after acute myocardial infarction (2000) (18)
Physiological consequences of over- or under-expression of fibrinolytic system components in transgenic mice. (1995) (18)
Regulation of cancer invasion and vascularization by plasminogen activator inhibitor-1 (1999) (18)
Heterogeneity in motoneuron disease (2007) (18)
Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I. (2007) (17)
Generation of monoclonal antibodies against autologous proteins in gene-inactivated mice. (1995) (17)
Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice (2015) (17)
Transient reduction of placental angiogenesis in PAI-1-deficient mice. (2011) (17)
Hypoxia-Ischemia or Excitotoxin-Induced Tissue Plasminogen Activator- Dependent Gelatinase Activation in Mice Neonate Brain Microvessels (2013) (17)
Nogo-A regulates vascular network architecture in the postnatal brain (2017) (16)
The glucocorticoid hormone dexamethasone reverses the growth hormone-releasing properties of the cholinomimetic carbachol. (1989) (16)
CLINICAL AND FUNDAMENTAL ASPECTS OF ANGIOGENESIS AND ANTI-ANGIOGENESIS (2007) (16)
Growth Arrest Specific Protein 6 Participates in DOCA-Induced Target-Organ Damage (2009) (16)
Endothelial cells and cancer cells: metabolic partners in crime? (2015) (16)
VEGF inhibitors make blood (2006) (16)
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (2014) (16)
Antenatal fetal VEGF therapy to promote pulmonary maturation in a preterm rabbit model. (2010) (16)
A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice (2017) (16)
1414 POSTER Single Nucleotide Polymorphism Analysis and Outcome in Advanced-stage Cancer Patients Treated With Bevacizumab (2011) (15)
Food‐restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve (2009) (15)
Placental Growth Factor Influences Maternal Cardiovascular Adaptation to Pregnancy in Mice1 (2015) (15)
Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model (2012) (15)
Hungry for blood vessels: linking metabolism and angiogenesis. (2008) (15)
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (2019) (15)
Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers (2012) (14)
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis (2010) (14)
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis. (2021) (14)
Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice. (2018) (14)
Role of Tissue‐Derived Plasminogen Activator (t‐PA) in an Excitotoxic Mouse Model of Neonatal White Matter Lesions (2004) (14)
How to teach an old dog new tricks: Autophagy-independent action of chloroquine on the tumor vasculature (2014) (14)
Adenovirus-mediated transfer of tissue-type plasminogen activator augments thrombolysis in tissue-type plasminogen activator-deficient and plasminogen activator inhibitor-1-overexpressing mice. (1997) (14)
Metabolic Reprogramming during Microglia Activation (2019) (14)
Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. (2015) (14)
Arterial neointima formation after trauma in mice with inactivation of the t-PA, u-PA or PAI-1 genes (1994) (13)
Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling. (2016) (13)
Vascular Endothelial Growth Factor (VEGF)-C Differentially Affects Tumor Vascular Function and Leukocyte Recruitment: Role of VEGF-Receptor 2 and Host VEGF-A 1 (2001) (13)
Genetic Studies on the Role of Proteinases and Growth Factors in Atherosclerosis and Aneurysm Formation (2001) (13)
Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential (2014) (13)
16LBA VEGFR-1 polymorphisms as potential predictors of clinical outcome in bevacizumab-treated patients with metastatic pancreatic cancer (2009) (13)
Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation (2019) (13)
A transgenic Xenopus laevis reporter model to study lymphangiogenesis (2013) (13)
Adenovirus-mediated gene transfer of rt-PA restores thrombolysis in t-PA deficient mice (1994) (12)
Gas6 deficiency in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease. (2010) (12)
Transgenic animals as tools for the study of fibrinolysis in vivo (1994) (12)
The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin (2001) (12)
Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain (2020) (12)
VEGF-B Improves Metabolic Health through Vascular Pruning of Fat. (2016) (12)
Vascular endothelial growth factor receptor 1 expression in nasal polyp tissue (2014) (12)
The role of endothelial cells in cystic fibrosis. (2019) (12)
Endothelial cell differentiation by SOX17: promoting the tip cell or stalking its neighbor instead? (2014) (12)
Bone resorption and response to calcium‐regulating hormones in the absence of tissue or urokinase plasminogen activator or of their type 1 inhibitor (1996) (11)
Cloning and Characterization of a cDNA Encoding Murine Coagulation Factor X (1998) (11)
Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease (2018) (11)
Nucleotide Structure and Characterization of the Murine Gene Encoding Anticoagulant Protein C (1998) (11)
Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes (2017) (11)
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis (2020) (11)
Treating diabetes by blocking a vascular growth factor. (2012) (11)
Impaired liver regeneration after partial hepatectomy in plasminogen deficient mice (2001) (10)
Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice. (2014) (10)
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes (2021) (10)
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis (2021) (10)
Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: Interaction with plasmin inhibitors and anti-inflammatory drugs (2007) (10)
1. Generation by Homologous Recombination and Characterization (1993) (9)
Influences of placental growth factor on mouse retinal vascular development (2017) (9)
Chapte rr 5 Plasminogenn activator inhibitor 1 and vitronectin protect againstt stenosis in a murine carotid artery ligation model (2007) (9)
New developments in the molecular biology of coagulation and fibrinolysis (1999) (9)
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth (2022) (9)
Role of Dll4/Notch in the Formation and Wiring of the Lymphatic Network in Zebra Fish (2010) (9)
Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis (2021) (8)
Receptor-independent plasminogen activation by urokinase-type plasminogen activator promotes, and adenoviral pai-1 gene transfer inhibits arterial neointima formation in mice (1996) (8)
The plasminogen system and cell migration during an inflammatory response (1996) (8)
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype (2020) (8)
The Development of Blood Vessels: Cellular and Molecular Mechanisms (2002) (8)
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization (2001) (8)
Lowering the increased intracellular pH of human‐induced pluripotent stem cell‐derived endothelial cells induces formation of mature Weibel‐Palade bodies (2020) (8)
Cardiovascular biology: Signalling silenced (2003) (8)
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat (2001) (8)
Endogenous GAS 6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow (2016) (8)
Gas6 is dispensable for pubertal mammary gland development (2018) (8)
Interleukin-6 a putative mediator of anterior pituitary hormone secretion during the stress of infection? (1990) (8)
The inhibitory effect of heparin for vascular smooth muscle cell proliferation or migration is not mediated by u-PA and t-PA. (1997) (8)
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level (2022) (8)
Neuro-vascular link: from genetic insights to therapeutic perspectives. (2008) (8)
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis (2021) (7)
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages (2017) (7)
The PHD2 oxygen sensor paves the way to metastasis (2015) (7)
Angiogenesis in the Central Nervous System (2008) (7)
Medicine: Genetic spotlight on a blood defect (2004) (7)
Tissue factor is not involved in the mitogenic activity of factor VIIa. (2001) (7)
Inactivation of the mouse urokinase-receptor gene (1994) (7)
Plasminogen deficiency leads to stagnant wound healing following myocardial infarction in mice (1998) (7)
Insights from gene-inactivation studies of the coagulation and plasminogen (1997) (7)
Gene inactivation of U-PA or adenoviral gene transfer of tissue inhibitor of metalloproteinases-1 impedes cardiac hypertrophy and fibrosis, but improves cardiac function during hypertension in mice (2000) (7)
Adult Pgf−/− mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor (2019) (7)
Novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis. (2006) (7)
Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease. (2021) (7)
Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches. (2016) (6)
Molecular atlas of the human brain vasculature at the single-cell level (2021) (6)
Ontogenic study of the influence of tissue plasminogen activator (t-PA) in neonatal excitotoxic brain insult and the subsequent microglia/macrophage activation (2005) (6)
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis (2021) (6)
Correction: MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells (2013) (6)
Metabolic Reprogramming in Tumor Endothelial Cells (2022) (6)
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis (2013) (6)
The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution (2022) (6)
Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis (2021) (6)
VEGF-loaded injectable hydrogel enhances plasticity in the injured spinal cord (2013) (6)
Erratum: Gene prioritization through genomic data fusion (2006) (6)
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast (2022) (6)
Vasculogenesis in kidney organoids upon transplantation (2022) (5)
Deletion of the Oxygen-sensor PHD2 in Chondrocytes Results in Increased Cartilage and Bone Mineralization (2008) (5)
Sunday, 26 August 2012 (2012) (5)
Gene targeting and gene transfer to unravel the molecular basis of the formation and disorders of blood vessels. (2000) (5)
De novo serine synthesis regulates chondrocyte proliferation during bone development and repair (2022) (5)
Mitochondrial respiration supports autophagy to provide stress resistance during quiescence (2022) (5)
Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis (2016) (5)
Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives (2022) (5)
The effects of disruption of plasminogen gene on vascular neointima formation: Analysis by the external vascular cuff-induced neointima formation mouse model (2000) (5)
Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling (2021) (5)
RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients. (2018) (5)
Abstract P3-06-34: Plasma (p) VEGF-A and VEGFR-2 biomarker (BM) results from the BEATRICE phase III trial of bevacizumab (BEV) in triple-negative early breast cancer (BC) (2012) (5)
The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors (2021) (5)
Tumor vessel co-option: The past & the future (2022) (5)
Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver (2021) (5)
Tissue factor. (1998) (4)
A Role for the Vascular Endothelium in Post–Acute COVID-19? (2022) (4)
Role of growth arrest specific gene 6 in immune and non-immune aspects of vascular lesions occurring during delayed xenograft rejection (2005) (4)
Prominin–1 Deficiency Leads to Progressive Retinal Degeneration (2005) (4)
Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle (2021) (4)
Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain. (2005) (4)
Identification of vascular cues contributing to cancer cell stemness and function (2022) (4)
Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis (2021) (4)
Regulation of the fibrinolytic system during gonadotropin-induced ovulation in mice with inactivation of the genes encoding tPA, uPA or PAI-i (1994) (4)
Isolated hearts of Delta KPQ SCN5A mutated (Long-QT3) mice exhibit bradycardia, early afterdepolarizations, and torsade de pointes arrhythmias which are suppressed by pacing or mexiletine (2002) (4)
Nigral degeneration following striato-pallidal lesion in tissue type plasminogen activator deficient mice (1999) (4)
Glomerulonephritis in mice with genetic deficiencies of the plasminogen system (1996) (4)
Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility (2020) (4)
Building in resistance to endothelial cell death (2007) (4)
RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients. (2018) (3)
Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers (2022) (3)
II. Effects on Hemostasis, Thrombosis, and Thrombolysis (1993) (3)
Corrigendum: PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin (2015) (3)
DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance (2020) (3)
Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish. (2018) (3)
1412 POSTER Genetic Markers in Relation to Bevacizumab-induced Hypertension (2011) (3)
Placental Growth Factor: a Novel, Stromal-Derived Target in Human CML. (2009) (3)
Two Faces of Adult Blood Vessel Formation: Vasculogenesis and Angiogenesis (2014) (3)
Erratum: The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation [EMBO Mol Med, 5, (2013) 1523-1536, DOI: 10.1002/emmm.201302847] (2014) (3)
Placental growth factor plays a role in the mesenteric neo-angiogenesis of portal hypertensive mice (2006) (3)
Deletion of the hypoxia-response element in the VEGF promoter causes adult onset motor neuron degeneration (2002) (3)
VEGF, a modifier of motor neuron degeneration in SOD1 G93A mice, protects against motor neuron loss after spinal cord ischemia: evidence for a vascular hypothesis (2003) (3)
Urokinase mediates bFGF-induced vascular smooth muscle cell migration under the control of TGFβ (1998) (2)
Targeted Disruption of GAS6-Mertk Pathway Leads to Defects in Physiological Clearance of Expelled Nuclei from Erythroblasts by Bone Marrow Macrophages. (2007) (2)
S84 Identification of MIR-124a as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension (2016) (2)
Role of VEGF-Receptor 2 and Host VEGF-A Affects Tumor Vascular Function and Leukocyte Recruitment: Vascular Endothelial Growth Factor (VEGF)-C Differentially (2001) (2)
ABSTRACTS: 2 Mouse PAI‐1 promotes placentation by increasing foetal and maternal angiogenesis (2008) (2)
Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle (2022) (2)
Endothelial metabolism going single (2021) (2)
S1657 Absence of Placental Growth Factor Aggravates DSS-Induced Acute Colonic Injury (2009) (2)
Angiogenesis goes computational – The future way forward to discover new angiogenic targets? (2022) (2)
Deletion or Inhibition of th e Oxygen Sensor PHD 1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism Graphical (2016) (2)
Generation and characterization of factor X deficient mice (1998) (2)
Retinal Angiogenesis and Growth Factors (2007) (2)
Biological Effects of Inactivation of the Genes for Tissue-type Plasminogen Activator, Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Mice (1993) (2)
S138 Nanodiamond Delivery Of Vascular Endothelial Growth Factor Promotes Fetal Lung Development In A Rat Model Of Congenital Diaphragmatic Hernia (2014) (2)
Corrigendum The (2014) (2)
Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics. (2019) (2)
Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation (2011) (2)
Vascular Progenitors: From Biology (2002) (2)
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation (2018) (2)
Targeting endothelial cell metabolism: new therapeutic prospects? (2015) (2)
Differential development of hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in transgenic mice with various deficiencies in the plasminogen/plasmin system (1999) (2)
Absence of microRNA-155 protects against adverse cardiac inflammation and hypertrophy during pressure overload and prevents heart failure (2012) (2)
Gas 6 deficiency in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease (2010) (2)
Molecular Analysis of Vascular Development and Disorders (1999) (2)
Role of Plasmin and uPAR in Bone Marrow HSC/HPC Retention and Mobilization. (2005) (2)
Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling (2017) (2)
Dwarfism and Osteopenia in Mice with Inactivated Hypoxia-Response Element in the VEGF Gene Promoter (2008) (2)
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice (2021) (2)
Essentials of Angiogenesis (2014) (2)
Growth Arrest-Specific Gene 6 (Gas6) Deficiency in Mice Alleviates Graft-versus-Host Disease (GVHD) in the Liver. (2004) (2)
articleDownregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ / δ mouse model of amyotrophic lateral sclerosis (2010) (2)
Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis (2021) (2)
Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. (2009) (2)
Scientific Statement From the American Heart Association State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A (2015) (1)
Critical Amplification by Gas6 of the Epo-Dependent Erythropoietic Response to Anemia: Novel Opportunities for Anemia Treatment. (2004) (1)
Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation (1998) (1)
The Cancer Cell Oxygen S ensor PHD 2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts Graphical (1)
The role of the VEGF-isoforms in pathological choroidal/retinal angiogenesis. (2011) (1)
Pulmonary effects of antenatal intratracheal VEGF administration and tracheal occlusion in preterm fetal rabbits (2007) (1)
Erratum: Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism (Cancer Research (April 1, 2003)(1500-1507)) (2003) (1)
Endothelial cell metabolism: parallels and divergences with cancer cell metabolism (2014) (1)
Tribute to Werner Risau (1999) (1)
Author Correction: COVID-19: the vasculature unleashed (2020) (1)
77 Urokinase-generated plasmin induces athero-sclerotic aneurysm formation via activation of matrix metalloproteinases (1997) (1)
Partial Inhibition Of The Key Glycolytic Enzyme Pfkfb3 In Myeloid Cells Impacts Whole-Body Immune Cell And Liver Metabolism, But Not Atherogenesis. (2019) (1)
Heparin-Binding Domain of Antithrombin Life-Threatening Thrombosis in Mice With Targeted Arg 48-to-Cys Mutation of the Print (2003) (1)
Functional validation of a genetic locus in the VEGFR-1 tyrosine kinase (TK) domain as a predictive marker for bevacizumab (2012) (1)
Mimecan is an essential regulator of extracellular matrix integrity after myocardial infarction (2010) (1)
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma. (2022) (1)
Erratum to: VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration (2013) (1)
Abstract 319: Novel Therapeutic Mechanism of Placental Growth Factor in Myocardial Infarction: Tissue Repair through Enhancement of Proliferation, Mobilization and Recruitment of BM-Derived Stem Cells for Cardiac Myoangiogenesis (2006) (1)
A novel role for VEGF-B in motorneuron degeneration in ALS (2005) (1)
Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)) (1998) (1)
Endothelial Cells Control Muscle Regeneration Through Angiocrine Lactate (2019) (1)
Evidence for Regulatory Cell-to-Cell Communication with Gonadotrophs, Lactotrophs, and Folliculostellate Cells in Rat Pituitary Cell Aggregates (1987) (1)
Corrigendum: PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin (2014) (1)
Urokinase receptor-deficiency reduces spontaneous atherosclerosis in LDL-receptor-deficient mice (2006) (1)
Fas-associated factor-1, a protein involved in apoptosis, causes cleft lip and palate (2008) (1)
76 Reduced transplant arteriosclerosis in plasminogen deficient mice (1997) (1)
Abstract 330: Mobilization Of Bone Marrow Progenitors By Ischemic Tissues Requires An Interplay Between Hematopoietic Cytokines And Placental Growth Factor (plgf) (2007) (1)
Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of (2008) (1)
Ischemia Induces Blood-retinal Barrier (BRB) Breakdown through HIF-1 Dependent VEGF Upregulation and VEGF Mediates BRB Breakdown through ICAM-1 and Adenosine (2003) (1)
Advances in Brief Vascular Endothelial Growth Factor ( VEGF ) Modulation by Targeting Hypoxia-inducible Factor-1 a 3 Hypoxia Response Element 3 VEGF Cascade Differentially Regulates Vascular Response and Growth Rate in Tumors 1 (2000) (1)
Two Faces of Adult Blood Vessel Formation (2014) (1)
NANODIAMOND DELIVERY OF VASCULAR ENDOTHELIAL GROWTH FACTOR PROMOTES FETAL LUNG DEVELOPMENT IN A RAT MODEL OF CONGENITAL DIAPHRAGMATIC HERNIA (2014) (1)
De novo serine synthesis regulates chondrocyte proliferation during endochondral ossification (2021) (1)
The acute hypoxic ventilatory response is augmented in PHD2-deficient mice (2008) (1)
Advantages of the Vegf Inhibitor, Macugen: A More Favourable Toxicity Profile (2008) (1)
Abstract LB-363: Inhibition of placental growth factor (PlGF) leads to regression of medulloblastoma (2010) (1)
Gram-negative pneumonia Plasminogen activator inhibitor type 1 is protective during severe (2013) (1)
FAF1, the First Gene Associated with Cleft Palate (2011) (1)
Plasminogen activator inhibitor type I (PAI-1) controls bone marrow-dependent and independent vascularization (2006) (1)
CD8+ T-Cell Metabolic Rewiring Defined by Single-Cell RNA-Sequencing Identifies a Critical Role of ASNS Expression Dynamics in T-Cell Differentiation (2021) (1)
Axl Represents a Therapeutic Target In T315I-Mutated and WT Chronic Myeloid Leukemia (2013) (1)
49 – Cell-to-Cell Communication in Peptide Target Cells of Anterior Pituitary (1989) (1)
Potential role of the VEGF homologue placental growth factor (PlGF) in neurogenesis (2002) (1)
Oral abstract presentations & Young Investigators Competition (2012) (1)
Shaping the brain vasculature in development and disease in the single-cell era (2023) (1)
Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition. (2021) (1)
Role of urokinase-type plasminogen activator in ventricular wall rupture, scar formation, and cardiac function after myocardial infarction (1999) (1)
Abstract LB-447: Functional validation of a genetic locus in the VEGFR-1 tyrosine kinase (TK) domain as a predictive marker for bevacizumab (2012) (1)
42 – Formation of Blood and Lymphatic Vessels: Role of Progenitors (2004) (1)
Abstract CT015: A phase 1 dose escalation study of TB-403 in pediatric relapsed or refractory medulloblastoma, neuroblastoma, Ewing sarcoma, or alveolar rhabdomyosarcoma (2021) (1)
INCREASED CARDIAC EXPRESSION OF TIMP-1 AND TIMP-2 IS RELATED TO CARDIAC FIBROSIS AND DYSFUNCTION IN THE CHRONIC PRESSURE-OVERLOADED HUMAN HEART.: PD.7 (2005) (1)
13PHD1 deficiency promotes an atheroprotective metabolic phenotype (2014) (1)
BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant (2014) (1)
Molecular and Cellular Angiogenesis (2002) (1)
Evaluation of transmitral pressure gradients at different heart rates: divergent action of isoprenaline and atropine. (1990) (1)
MicroRNA-146a interferes with TCA cycle flux via DLST and rewires cardiomyocyte metabolism in hypertensive heart failure (2014) (1)
CPT1a-dependent long-chain fatty acid oxidation is essential for maintaining glucagon secretion from pancreatic islets (2018) (1)
State-ofthe-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization (2015) (1)
How to Cross the Lymphatic Fence: Lessons From Solute Transport. (2017) (1)
CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation. (2022) (1)
265 DEVELOPMENT OF CIRRHOSIS IS ASSOCIATED WITH INCREASED LEVELS OF PLACENTAL GROWTH FACTOR: A DESCRIPTIVE STUDY (2008) (1)
Impaired wound healing in mice lacking placental growth factor (1997) (1)
Primary-Tumor-mediated Dormancy of disseminated Breast Cancer Cells in the Bone Marrow due to Down-Regulation of Gas6 (2013) (1)
Gene prioritization by genomic data fusion (2007) (1)
Complete inhibition of cardiac wound healing after myocardial infarction in plasminogen deficient mice (1998) (1)
78 Receptor-independent role of urokinase-type plasminogen activator during vascular wound healing in mice (1997) (1)
NuSAP is essential for chromatin-induced spindle formation during early embryogenesis (2010) (1)
-Induced Abdominal Sepsis in Mice coli Escherichia Activator Is Protective during Endogenous Tissue-Type Plasminogen (2006) (1)
Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. (2020) (1)
Abstract (2003) (0)
Axl, a therapeutic target in AML mediates stroma-induced chemoresistance (2013) (0)
ID: 275 The plasminogen activation system and skeletal muscle regeneration (2006) (0)
Subjects Index, Vol. 26, Supplement 4, 1996 (1996) (0)
Cardias TIMP-1 and TIMP-2 expression: markers of interstitial fibrosis in patients with aortic stenosis (2004) (0)
Genetic markers of bevacizumab-induced hypertension (2014) (0)
Vascular biology and pathophysiological mechanisms (2000) (0)
Blocking primary tumor growth and metastasis by inhibiting PlGF (2006) (0)
Vascular smooth muscle cell apoptosis in atherosclerotic plaques is mediated by plasminogen activation (2004) (0)
[Cardiovascular stem cell research in interactions between the university and industry]. (2003) (0)
Physiological effects of inactivation of the genes encoding t-PA, u-PA and PAI-1 (1994) (0)
Myeloid PHD2 deficiency stimulates macrophage collagen production and atherosclerotic plaque stability in mice (2017) (0)
CHLOROQUINE MEDIATES ITS ANTICANCER EFFECTS IN AN AUTOPHAGY-INDEPENDENT MANNER BY ACTING ON THE TUMOUR VASCULATURE (2015) (0)
Urokinase but not tissue-type plasminogen activator is involved in collateral artery growth (2001) (0)
The Role of gas6 in Venous Thrombosis In Vivo. (2009) (0)
Altered VEGF-A isoform expression during embryogenesis affects arterial, venous and lymphatic differentiation (2006) (0)
Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia against (2007) (0)
Pathophysiology of fibrinolysis (1994) (0)
NuSAP inactivation during embryogenesis triggers mitotic defects leading to cell cycle arrest and cell death (2009) (0)
ThemechanismsofBMhematopoieticstem/progenitorcell(HSPC)adhesion,engraftment,andmobilization remainincompletelyidentified.Here,usingWTandtransgenicmice,wehaveshownthatmembrane-anchored plasminogenactivator,urokinasereceptor( M uPAR)marksasubsetofHSPCsandpromotesthepreserva- tionofthesizeofthispoolofc (2009) (0)
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis (2020) (0)
Novel roles of plasmin, uPAR and suPAR in mobilization and retention of HSC/HPCs (2005) (0)
Xenopus tadpoles: a novel model to study functionally the genetic basis of lymphangiogenesis (2004) (0)
Do we need other targets for treating angiogenic disorders: novel opportunities with PLGF (2003) (0)
Abstract 15497: Macrophage Polarization Induced by Phd2 Haplodeficiency Prevents Ischemic Damage by Inducing Collateral Vessel Activation (2010) (0)
Endothelial Phalanx cell for therapeutic angiogenesis (2010) (0)
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 (2023) (0)
Evidence for a role of placental growth factor inhibition in the treatment of AMD (2010) (0)
Inactivation of the PHD2 oxygen sensor improves periosteal cell survival during early phases of bone regeneration (2013) (0)
Metastatic melanoma are addicted to mitophagy to maintain redox and metabolic homeostasis (2012) (0)
Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia (2018) (0)
Disruption of the protein C inhibitor (PCI) gene does not result in hemostatic abnormalities but in impaired spermatogenesis and infertility in male PCI-/- mice (2000) (0)
Vascular and Neuronal Development: Intersecting Parallelisms and rossroads (2007) (0)
Using VEGF165 and counterparts to treat neuron disorders. (2001) (0)
Combined deficiency of prolyl hydroxylase (PHD) 1 and PHD3 increases mesenchymal stem cell number and regulates the hematopoietic stem cell niche (2013) (0)
The mechanism, efficacy and safety of anti-placental growth factor (PlGF) antibodies in CNV formation in a mouse model for ARMD (2007) (0)
Blockage of PLGF improves inflammation, fibrosis, and portal pressure in cirrhotic mice (2010) (0)
Aha Scientific Statement 1. in Vitro Assays State-of-the-art Methods for Evaluation of Angiogenesis and Tissue Vascularization a Scientific Statement from the American Heart Association on Behalf of the American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular (2015) (0)
Effects of disruption of genes encoding the plasminogen/plasmin system on vascular neointimal formation in mice (1997) (0)
Loss Of Endothelial Glycocalyx Hyaluronan Upon Glycolytic Activation Results In Reduced Angiopoietin-1 Signaling And Vascular Destabilization (2017) (0)
Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension (2021) (0)
Abstract 310: Thrombospondin 2 Protects Against Uncontrolled Cardiac Inflammation and Injury During Viral Myocarditis (2008) (0)
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis (2020) (0)
M eta-analysis of clinical metabolic profiling studies in cancer : challenges and opportunities (2016) (0)
Title Page / Table of Contents, Vol. 26, Supplement 4, 1996 (1996) (0)
Anti-PlGF (placental growth factor) as a safer alternative for anti-VEGF in the treatment of age-related macular degeneration (AMD)? (2008) (0)
Uncovering new roles of the endoplasmic reticulum stress kinase PERK beyond the unfolded protein response (2014) (0)
Effect of propranolol on heart rate and arrhythmias in telemetry ECGs of Δ/+KPQ SCN5A mice with long QT syndrome 3 (2005) (0)
Sepsisthe Innate Immune Response to Abdominal Loss of the Oxygen Sensor PHD3 Enhances (0)
VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration (2013) (0)
Abstract 1713: Urokinase Receptor-Deficiency Reduces Spontaneous Atherosclerosis in LDL-receptor-deficient Mice (2006) (0)
142 PLGF Expression By Tumor Stromal Cells Is Induced Via Tumor Cell-Tumor Stromal Crosstalk and Substantially Contributes to Tumor Growth (2008) (0)
Inhibition of proteinases prevents cardiac injury during viral myocarditis (2004) (0)
1P-0210 Effects of endogenous placental growth factor on vascular permeability in pathological conditions (2003) (0)
VEGF is a modifier gene of amyotrophic lateral sclerosis in humans (2003) (0)
Unconventional splice site mutation in SCN5A as cause (and modifier?) of overlapping phenotypes of Brugada syndrome and isolated cardiac conduction defect (2004) (0)
VEGF is a novel guidance cue for the initiation of granule cell radial migration (2007) (0)
The role of PHD2 in breast cancer metastasis (2012) (0)
Angiogenesis revisited: Endothelial cell metabolism as a target? (2015) (0)
The oxygen-sensor PHD2 in chondrocytes modifies bone mass by regulating cartilage collagen processing (2010) (0)
Erratum to: VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration (2013) (0)
Inactivation of the tissue factor gene results in embryonic lethality due to abnormal vasculogenesis (1996) (0)
DLis1 and neurodegeneration (2009) (0)
Angiogenic factors and fibrinolytic system plays different roles in adhesion formation following laparoscopy (2002) (0)
Myocardial and cerebral perfusion studies in animal models S 65 119 In-vivo phenotyping of genetically engineered mouse models for amyotrophic lateral sclerosis is established by combining BT-MRI and CASL (2004) (0)
Non-angiogenic functions of VEGF (2006) (0)
The autophagy blocker chloroquine normalizes the tumor vasculature (2015) (0)
PE-380 Therapeutic Myoangiogenesis by Direct Intramyocardial Gene Transfer of Naked DNA Encoding Placental Growth Factor 1 in Acute Myocardial Infarction(Genetics/Genetically engineered models/Gene therapy-2 (M) PE64,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japa (2006) (0)
GAS6 PROTEIN AND ITS ROLE IN VASCULAR CALCIFICATION (2013) (0)
P477Myeloid PHD-2 deficiency leads to enlarged and fibrotic atherosclerotic plaques in mice (2014) (0)
348 Effect of propranolol on heart rate and arrhythmias in freely moving mice and isolated hearts of deltaKPQ-SCN5A LQT3 mice (2005) (0)
[New non-metabolic role for glutamine synthetase in angiogenesis]. (2019) (0)
Inactivation of urokinase-type plasminogen activator receptor induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice closely mimicking human systemic sclerosis (2013) (0)
Phd 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (0)
Retinal And Choroidal Neovascularization, Blood-retinal Barrier Breakdown, And Apoptosis Are Inhibited In The Absence Of Prolyl Hydroxylase-1 (2011) (0)
Placental growth factor (PlGF) inhibition reduces choroidal neovascularization in a mouse model for age-related macular degeneration (2007) (0)
MRI of a distal MCAI ischemic stroke lesion model in mice (2015) (0)
erratum Perinuclear localizationof chromatin facilitates transcriptional silencing (0)
Generation and preliminary characterization of PTPA gene-trapped mice (2010) (0)
Rapid Publication Generation and Characterization of Urokinase Receptor-deficient Mice (1996) (0)
Pulmonary effects of antenatal intratracheal VEGF administration in preterm fetal rabbits (2006) (0)
Urokinase receptor deficiency reduces neutrophil recruitment in sepsis and ameliorates survival (2002) (0)
Bmx tyrosine kinase has a redundant function downstream of growth factor receptors in arterial endothelium (2001) (0)
Role of proteinases in atherosclerosis (1999) (0)
Animal models of cardiovascular disease (1999) (0)
Inhibition of PlGF as a potential therapy against hepatocellular carcinoma (2010) (0)
Glucose metabolism via the pentose phosphate pathway controls chondrocyte survival and proteostasis during bone development (2021) (0)
61. Functional consequences of genotypic differences studied by high-resolution respirometry in small samples of permeabilized skeletal muscle fibers (2009) (0)
Tail regeneration in Xenopus laevis: a novel model to study angio- and lymphangiogenesis (2006) (0)
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis (2018) (0)
Construction of a mouse model of factor IX deficiency. (1997) (0)
Evidence for the role of placental growth in the treatment of age-related macular degeneration (2010) (0)
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes (2019) (0)
The use of antibodies against the placental growth factor in the prophylactic and therapeutic setting in portal hypertensive mice (2008) (0)
Effects of VEGFR-2- and VEGFR-1-ligands on adult neural stem cell derived neurosphere cultures in physiological and pathological conditions (2003) (0)
Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis (2022) (0)
Macrophage Accumulation Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and (2005) (0)
Consensus guidelines for the use and interpretation of angiogenesis assays (2018) (0)
Cooperation between a tumor protease (MT4-MMP) and a host-derived protease inhibitor (PAI-1) in tumor growth and metastatic dissemination (2006) (0)
Genetic and chemico-genetic lymphangiogenesis study of VEGFR-3 and its ligands VEGF-D and VEGF-C in Xenopus laevis tadpoles (2006) (0)
HIF-1α stabilization in Phd1/3-/- mice results in increase in hematopoietic stem cell number and enhanced HSC maintenance in BM niche (2013) (0)
Network in Zebrafish Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic (2012) (0)
Regulation of Developmental and Pathological Angiogenesis by Tissue Factor Cytoplasmic Domain Signalling (2004) (0)
PARP inhibition promotes endothelial‐like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry (2022) (0)
NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease (2023) (0)
Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling (2021) (0)
Regulation of Protein kinase D2 by Hsp is crucial for tumour cell-endothelial cell communication in gastrointestinal tumours (2012) (0)
Blocking primary tumor growth and lymphatic metastases by targeting PlGF (2006) (0)
Matrix deformations around angiogenic sprouts correlate to sprout dynamics and suggest pulling activity (2020) (0)
The metabolic engine of endothelial cells (2019) (0)
Placental growth factor is a positive regulator of bone remodeling (2005) (0)
Use of VEGF and homologues to treat neurological disorders (2001) (0)
Myeloid Phd2 Knockdown Drives Macrophage Apoptosis And Paracrine Fibroblast/Smooth Muscle Cell Collagen Secretion Leading To Atherosclerotic Plaque Fibrosis (2019) (0)
Jeffrey Michael Isner 1947-2001 (2001) (0)
Growth Arrest-Specific Gene 6 product modulates innate immunity in sepsis (2008) (0)
165 JNJ-26483327, a second-generation spectrum-targeted protein tyrosine kinase inhibitor with superior characteristics in advanced cancer models (2010) (0)
The use of antibodies against the placental growth factor as a new therapeutic target in the pathophysiology of portal hypertensive mice (2008) (0)
Mice deficient in growth arrest specific gene 6 (Gas6) show increased hemorrhage in atherosclerosis, myocardial infarction and after LPS-footpad injection and exhibit increased VEGF induced capillary hyperpermeability (2003) (0)
Soluble VEGF isoforms are essential to establish vascularization of cartilage elements and regulate development and survival of growth plate chondrocytes (2003) (0)
Tumor vessel disintegration by maximum tolerable PFKFB3 blockade (2017) (0)
OC12. Specific inhibition of the VEGF homolog placental growth factor is protective against osteolytic bone metastasis in mice (2007) (0)
Ischemia- and cytokine-mediated, mobilization and proliferation of hematopoietic and endothelial stem/progenitor cells require placental growth factor (PlGF) (2003) (0)
Abstract SY15-04: Angiogenesis revisited: Endothelial cell metabolism as a target (2015) (0)
PHD1 and PHD3 are expressed in bone cells but are not essential for bone homeostasis (2007) (0)
PLACENTAL GROWTH FACTOR/NEUROPILIN 1 SIGNALING IS A THERAPEUTIC TARGET IN PEDIATRIC MEDULLOBLASTOMA (2013) (0)
Unraveling the in vivo mechanism of action of the autophagy inhibitor chloroquine in anti-cancer therapy (2013) (0)
Blood flow deficits due to perivascular nerve degeneration: a novel mechanism of ALS (2005) (0)
Use of VEGF and homologs for treating neurological disorders (2001) (0)
Revealing an autophagy-independent anticancer mechanism of chloroquine (2013) (0)
Evidence for the efficacy of PlGF inhibition in age‐related macular degeneration (2010) (0)
D005 Proteolysis of angiogenic factors associated with intraplaque hemorrhages in human atherothrombotic plaques (2009) (0)
Functional role of the oxygen sensors PHD1, PHD2 and PHD3: a gene-inactivation study in mice (2006) (0)
Hypoxia tolerance induced by deficiency of the oxygen sensor PHD1: study of the basel metabolism by MR Spectroscopy (2008) (0)
Pneumococcal Pneumonia Adequate Host Defense Against Urokinase Receptor Is Necessary for Speelman (2002) (0)
Angiogenesis and the neurovascular link (2012) (0)
VEGF protects sensory axons against a retrograde axonopathy: implications for anti-angiogenic therapies (2010) (0)
European Mathematical Genetics Meeting, Heidelberg, Germany, 12th–13th April 2007 (2007) (0)
Endothelial Growth Factor B Endothelial Fatty Acid Transport: Role of Vascular (2013) (0)
PO-405 Blockade of endothelial cell glycolysis to improve current immunotherapy (2018) (0)
Cell Metabolism Previews TreatingDiabetesbyBlockingaVascularGrowthFactor (2012) (0)
Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells (2022) (0)
Expression and role of Placental Growth Factor (PLGF) in the inflammatory context resulting from nerve injury, the Wallerian Degeneration. (2006) (0)
Generation of mice with inactivated or mutagenized urokinase receptor genes (1995) (0)
Reduction in autophagic flux cooperates with hypoxia to drive melanomagenesis (2011) (0)
Activation of the UNC5B receptor by Netrin‐1 inhibits neovascularization (2007) (0)
Preconditioning periosteal cells by inactivation of the Phd2 oxygen sensor improves their bone forming capacity in a large segmental bone defect (2013) (0)
The small molecule axl inhibitor BGB324 shows activity against T315I-mutated and BCR-ABL1 wt chronic myeloid leukemia (2014) (0)
Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential (2014) (0)
Abstract LB-362: PlGF inhibition phenocopies PlGF deficiency in cancer (2010) (0)
Improved metabolite identification with MIDAS and MAGMa through MS/MS spectral dataset-driven parameter optimization (2016) (0)
Mouse Models to Study Pro-and Antiangiogenic Potential: Novel Roles for PLGF and FLT1 (2004) (0)
Dilated cardiomyopathy caused by lamin A/C mutation : need for a prospective study to prevent sudden death in lamin A/C mutation carriers (2003) (0)
Reduced Cell Proliferation and Chondrodysplasia in Mice Lacking the Mitotic Protein NuSAP (2008) (0)
Gas6, a novel protein of hemostasis (2002) (0)
Bone marrow transplantation significantly rescues the skeletal muscle regeneration defect of uPA(-/-) mice after injury (2005) (0)
A monoclonal antibody against murine PlGF blocks primary tumor growth in syngeneic mouse tumor models (2005) (0)
Antibodies against placental growth factor prevent CO2 pneumoperitoneum-enhanced adhesion formation following laparoscopic surgery in mice (2003) (0)
A CLEVER molecule that regulates lymphoctye trafficking (2004) (0)
VEGF may induce axonal sprouting and preserve neuromuscular junction integrity in vivo (2006) (0)
Abstract 18804: Chronic Pressure Overload Impairs Cardiac Microvascular Endothelial Cell Metabolism and Angiogenic Potential in Aortic Stenosis Patients (2016) (0)
Preconditioning mouse periosteal cells to hypoxia by inactivation of the Phd2 oxygen sensor improves in vivo ectopic bone formation (2012) (0)
Use of VEGF and homologs for treatment of neuronal diseases (2001) (0)
Evidence for involvement of the plasminogen activator system in the aetiology of plaque destabilization and rupture (2002) (0)
Two cases of cyclic neutropenia with acquired CSF 3 R mutations , with 1 developing AML (2016) (0)
The effect of Vascular Endothelial Growth Factor (VEGF) on Motoneuron Degeneration (2003) (0)
Use of PLGF for the prevention or treatment of ischemia or stroke (2001) (0)
The vegf family: roles in angiogenesis and inflammatory disorders (2008) (0)
Corrigendum to “Impact of placental growth factor deficiency on early mouse implant site angiogenesis” [Placenta 35 (2014) 772–775] (2015) (0)
Genetic insights on the role of PIGF in ocular angiogenesis and inflammation (2010) (0)
NuSAP inactivation in vivo triggers mitotic defects leading to cell cycle arrest and cell death (2009) (0)
A Fatty Acid Oxidation-De pendent Metabolic Shift Regulates Adult Neural Stem Cell Activity Graphical Abstract Highlights (2017) (0)
Treatment of an aggressive form of motor neuron degeneration by VEGF protein and gene transfer in ALS animal models (2004) (0)
HIF–1 induced VEGF augments, but is not essential for normal retinal vascular development (2004) (0)
Slowing and prevention of vision loss in Retinitis Pigmentosa of the 'Protein Logistics Disease' type (2016) (0)
Abstract 1248: Effect of {beta}-adrenergic Stimulation or Parasympathetic Stimulation in deltaKPQ-SCN5A Mice with Long QT Syndrome 3 (2006) (0)
Genetic and chemico-genetic lymph/angiogenesis studies in tadpoles, zebrafish and mice (2006) (0)
Proteomic analysis to identify the pathophysiological role of placental growth factor (Plgf) in hepatic stellate cell function and cirrhosis (2008) (0)
Abstract (2003) (0)
Airway Hyper-Responsiveness Associated With Sickle Cell Disease Is Mediated By Placenta Growth Factor (2013) (0)
The Wnt/frizzled/dishevelled tissue polarity cascade as a key determinant of heart failure development after Ml (2001) (0)
Utilization growth factor for preventing or treating ischemic heart diseases or cardiovascular events. (2001) (0)
Molecular Biology of the Plasminogen System: the Delicate Balance between Tissue Healing and Tissue Destruction (2002) (0)
Placenta Growth Factor Links the IL-13 Response and the Leukotriene Pathway to Augment Airway Hyper-Responsiveness (2015) (0)
67 Physiological consequenses of plasminogen deficiency on fertility and ovulation efficiency (1997) (0)
endothelial cells, platelets and leukocytes GAS6 promotes inflammation by enhancing interactions between (2013) (0)
Sunday, 18 July 2010 (2010) (0)
Inhibition of tumor angiogenesis and growth by an oral extracellularly-acting small-molecule multi-FGF receptors blocker with allosteric properties (2013) (0)
Glutamine metabolism in osteoprogenitors governs bone mass accrual and PTH-induced bone anabolism (2020) (0)
HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury (2022) (0)
Heterozygous deficiency of the oxygen sensor PHD2 prevents metastasis by inducing vessel normalization (2008) (0)
Formation and Disorders of Blood and Lymph Vessels (2005) (0)
826: PlGF deficiency results in sFlt-1 elevation without the onset of preeclampsia in pregnant mice (2017) (0)
The autophagy-blocker chloroquine promotes tumor vessel normalization by increasing Notch-signaling (2012) (0)
in Mice Alters Uterine NK Cells Genetic Deletion of Placenta Growth Factor (2007) (0)
Cancer cell PHD2 promotes metastasis by activating cancer-associated fibroblasts (2014) (0)
Placental growth factor is essential for normal fracture healing in mice by affecting inflammation, angiogenesis and mesenchymal cell development (2004) (0)
Lack of aneurysm formation in atherosclerotic aorta from urokinase deficient mice (1997) (0)
CVR-2020-1310 Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension (2021) (0)
Animal models for the study of angiogenesis (2002) (0)
Tolerance Associated with Eye Plasminogen Activator Promotes Peripheral NKT Cell-Derived Urokinase-Type (2007) (0)
Targeting angiogenic metabolism in disease Targeting endothelial cell metabolism offers new therapeutic opportunities for various conditions (2018) (0)
Gas6: an orchestrator of platelet-endothelial-leukocyte cell interactions during hemostasis and inflammation (2006) (0)
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation (2023) (0)
The in vivo mechanism of action of the autophagy inhibitor chloroquine in anti-cancer therapy unraveled (2013) (0)
Use of Axl, a therapeutic target in AML, to mediate stroma-induced chemoresistance. (2013) (0)
Abstract IA06: Angiogenesis revisited: Role and (therapeutic) implications of endothelial metabolism (2016) (0)
BGB324 Inhibits BCR-ABL TKI-Resistant Chronic Myeloid Leukemia (2015) (0)
The cytoplasmic domain of tissue factor plays an important role in innate and adaptive immunity (2003) (0)
Generation of mice with mutagenized u-pa genes, via the cre/lox recombination strategy (1996) (0)
PTPA (PPP2R4) as a novel candidate tumor suppressor: evidence from PTPA-deficient mice and human tumors (2013) (0)
Deficiency Exacerbates Arthritis Tissue-Type Plasminogen Activator (2001) (0)
oss or Silencing of the PHD 1 Prolyl Hydroxylase Protects Livers of Mice gainst Ischemia / Reperfusion Injury (0)
and edema formation A critical role of placental growth factor in the induction of inflammation (2013) (0)
Use of inhibitors of the placental growth factors for the treatment of pathological angiogenesis, pathological arteriogenesis, inflammation, tumor formation and / or vascular permeability (edema) (2001) (0)
Role of plasminogen activators and matrix metalloproteinases in matrix degradation (1998) (0)
Tissue-Type Plasminogen Activator Deficiency Exacerbates Arthritis 1 (2001) (0)
THE ROLE OF VEGF-ISOFORMS IN CORONARY DEVELOPMENT (2004) (0)
Placental growth factor induces osteoclast differentiation by an autocrine and paracrine pathway (2006) (0)
Cytokine production following stimulation with low molecular weight urokinase plasminogen activator for 48 hours (2011) (0)
Use of VEGF 165 and homologs for treating neuronal diseases (2001) (0)
Abstract 3446: Therapeutic Neovascularization by Catheter-Based, Intramyocardial Gene Transfer of Naked DNA Encoding Human Placental Growth Factor in Swine Chronic Myocardial Ischemia (2008) (0)
461 Third generation anti-angiogenic strategies: novel players, novel principles (2010) (0)
The role of placental growth factor in the nervous system (2008) (0)
112 Thrombospondin‐2 guards against aging‐related cardiomyopathy by increasing beta 1‐integrin mediated signaling (2008) (0)
Photofeature: European cardiovascular researchers on holiday and outside of work (2010) (0)
VEGFC targeted therapy reduces the CD34+ AML expansion by enhanced differentiation and apoptosis; A role for simultaneous glycolysis inhibition (2018) (0)
Soluble VEGF isoforms are essential to establish epiphyseal vascularization and regulate cartilage development and survival (2003) (0)
VEGF inhibitors aggravate ALS, possibly by reducing neural perfusion (2006) (0)
Development of the Vasculature, Angiogenesis, Lymphangiogenesis (2012) (0)
In vivo analysis of vascular function (2003) (0)
Modeling lymphangiogenesis in a 3 D-culture system (2009) (0)
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis (2022) (0)
Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy (2014) (0)
Regulation de la formation des adherences tissulaires (2003) (0)
Placenta Growth Factor is not essential for spiral artery modification in pregnant mice (2005) (0)
Physiological consequences of loss of plasminogen gene function (1995) (0)
328 Role of the Fragile X Mental Retardation Protein in Tumor Progression and Metastasis Formation (2012) (0)
Abdominal Aortic Aneurysm Induced − Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin II (2003) (0)
VEGF is a guidance signal for granular cell during cerebellar development (2006) (0)
Vasculogenesis in kidney organoids upon transplantation (2022) (0)
Tumor vessel normalization by the autophagy blocker chloroquine: role of endothelial Notch signaling (2013) (0)
283 u‐PA‐inactivation or TIMP‐1‐overexpression prevents cardiac injury and dysfunction during acute viral myocarditis in mice (2004) (0)
Thrombospondin-2 acts as a soldier against age-related cardiomyopathy (2006) (0)
The role of hypoxia in the physiology and pathology of menstruation (2017) (0)
Biological Effects of Targeted Gene Inactivation and Gene Transfer of the Coagulation and Fibrinolytic Systems in Mice (1997) (0)
ROLE OF GLUTAMINE SYNTHETASE IN ANGIOGENESIS 1 BEYOND GLUTAMINE SYNTHESIS 2 3 (2018) (0)
Genetic Biomarkers for Anti-angiogenic Therapies – a Race to Report (2010) (0)
Gas6 and Its Receptors Are Implicated in Sepsis as Modulators of Innate Immunity. (2007) (0)
G ENETIC LOSS OF G AS 6 INDUCES P LAQUE S TABILITY IN EXPERIMENTAL A THEROSCLEROSIS (2014) (0)
Targeting PHD2 oxygen sensor: novel and promising avenue to treat cancer (2010) (0)
Paradoxical increase of plaque growth and collagen deposition in atherosclerotic mice lacking plasminogen activator inhibitor-1 (PAI-1) (2000) (0)
Abstract 15979: Endothelial Cell Metabolism is Controlled by the Flow-induced Long Non-coding Rna Lncflow2 (2017) (0)
Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level (2022) (0)
HIF-1α dependent metabolic reprogramming of periosteal cells improves bone repair (2014) (0)
Glucose metabolism prevents ferroptosis and secures proteostasis in the developing growth plate (2022) (0)
Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3 (2013) (0)
u-PA-Gene Inactivation or TIMP-1-Gene Transfer Impairs Cardiac Injury Caused by Viral Myocarditis in Mice (2002) (0)
Abstract 202: Thrombospondin-2 Protects Against Uncontrolled Cardiac Inflammation and Oxidative Stress During Doxorubicin-Induced Myocarditis (2006) (0)
University of Birmingham Tumour hypoxia causes DNA hypermethylation by reducing TET activity (2016) (0)
Effect of PlGF-inhibition on survival in mice with hepatocellular carcinoma (2010) (0)
Aberrant PFKFB3-induced glycolysis in neurons in vivo causes mouse behavioral impairment by mitochondrial redox stress (2021) (0)
The lymphatic ring assay: a 3D culture system for discovering novel genes and mechanisms that regulate lymphangiogenesis (2007) (0)
PP63 Predictive markers in patients with upper gastrointestinal (GI) cancers treated with erlotinib and bevacizumab in a multicenter phase II trial (2009) (0)
Abstracts: Basic Science in arrhythmias: mechanisms (2009) (0)
Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. (2016) (0)
Phenotype molding of stromal cells in the lung tumor microenvironment (2018) (0)
522 Increased expression of syndecan‐1 protects against cardiac dilatation and dysfunction after myocardial infarction (2006) (0)
The matricellular proteins thrombospondin‐2, osteonectin and osteoglycin modulate cardiac inflammation, injury and function during viral myocarditis. (2012) (0)
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance (2020) (0)
Retinal Vascular Permeability Is Regulated by VEGFR1 and VEGFR2 (2006) (0)
Replacement of SERCA2a with the non-muscle SERCA2b isoform in transgenic mice (2000) (0)
Abstract A75: Serine auxotrophy: A novel metabolic vulnerability of platinum-resistant ovarian cancer? (2020) (0)
Authors Index, Vol. 26, Supplement 4, 1996 (1996) (0)
Role of VEGF isoforms in the eye (2006) (0)
Characteristics of cardiac action potential in LQT3 transgenic mice (2001) (0)
Hypoxic pulmonary-hypertension in transgenic mice with loss of plasminogen-activator and plasminogen-activator inhibitor gene-function (1995) (0)
Absence of microRNA‐155 protects against pressure overload‐induced cardiac inflammation and failure (2012) (0)
Decreased bone resorption and increased trabecular bone mass in female mice lacking placental growth factor (2003) (0)
Micro-RNA 146a: a new kid on the block in the pathophysiology of cardiac hypertrophy and hypertensive heart failure, and a promising therapeutic target (2012) (0)
Placenta Growth Factor (PlGF) mediates mobilization of monocytes and myeloid progenitors during post-ischemic growth, and is a modulator of myeloid differentiation and activation (2002) (0)
Metabolic and innate immune cues merge into a specific inflammatory response via unfolded protein response (UPR) (2020) (0)
Loss of prolyl hydroxylase-1 protects in colitis through reduced epithelial cell apoptosis and enhanced barrier function Short Title: PHD1 loss is protective in colitis (0)
P0290 : Placental growth factor inhibition modulates the interplay between hypoxia and the unfolded protein response in hepatocellular carcinoma (2015) (0)
CHAPTER 19 – VEGF, an Angiogenic Factor with Neurotrophic Activity, Useful for Treatment of ALS? (2006) (0)
THU-03 Angiogenesis inhibition in cancer (2013) (0)
Adult Pgf−/− mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor (2019) (0)
PPP2R4 is a novel haploinsufficient human tumor suppressor gene (2014) (0)
Deficiency in Placental Growth Factor improves inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic mice (2009) (0)
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds (2022) (0)
The use of placenta growth factor in the prevention or treatment of ischemic diseases or stroke (2001) (0)
Abstract IA17: Targeting placental growth factor/ neuropilin-1 pathway inhibits growth and spread of medulloblastoma (2014) (0)
Autophagy inhibition affects melanoma cell survival, redox and metabolic homeostasis by altering mitochondrial function (2011) (0)
Heart valve tissue-engineered matrices attenuate monocyte binding and procoagulant responses in human endothelial cell cultures exposed to S. aureus, S. sanguis and S. epidermidis (2012) (0)
Inhibition of PlGF for the treatment of leukemia positive for the Philadelphia chromosome (2009) (0)
Plasminogen activator (PA) deficient mice reveal that plasmin is abundant in the ovary prior to ovulation and required for efficient physiological ovulation (1996) (0)
Response to the correspondence article: Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype. (2021) (0)
A monoclonal anti-PlGF antibody inhibits tumor growth and lymphatic metastasis without affecting healthy vessels (2007) (0)
0020: Role of HIF-1 in the cardiac remodeling and inotropic effects of chronic intermittent hypoxia (2014) (0)
Hypoxia Inducible Factor Activation Prevents Renal Mitochondria Dysfunction and Improves Cortical Oxygenation in Type 1 Diabetic Mice (2019) (0)
P021 CFTR loss of function leads to increased ROS and endothelial dysfunction (2019) (0)
Intervention studies utilizing an apolipoprotein E knockout mouse model of plaque rupture (2002) (0)
Anti-PlGF (Placental Growth Factor) Reduces Choroidal Neovascularization in a Mouse Model of Age-Related Macular Degeneration (ARMD) (2008) (0)
Flk1-GFP transgenic reproter Xenopus laevis tadpoles to study angiogenesis and lymphangiogenesis (2010) (0)
In memoriam. Tribute to Werner Risau: December 18, 1953-December 13, 1998. (1999) (0)
Therapeutic Potential of Allosteric Modulation of FGF Receptors (2017) (0)
The 9p21 locus interacts with obesity to increase atherosclerotic burden (2009) (0)
Abstract 2176: Prenatal Hypoxic Stress Causes Cardiomyopathy Involving Cardiomyocyte Specific Vascular Endothelial Growth Factor Signaling (2006) (0)
Plasminogen activator inhibitor type-1 deficient (PAI-/-) mice show an improved early host defence in E. coli peritonitits by a neutrophil-dependent mechanism (2003) (0)
VEGF IN FUNCTIONAL MATURATION AND SYMPATHETIC INNERVATION OF ARTERIES (2004) (0)
Novel Role of Plasmin in Mobilization and of uPAR in Retention of Hematopoietic Stem/Progenitor Cells in the Bone Marrow Niche: Therapeutic Implications. (2004) (0)
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin (2018) (0)
Extracellular lipid availability determines skeletal progenitor cell fate (2018) (0)
The use of antibodies against the placental growth factor in the prophylactic setting in the pathophysiology of portal hypertensive mice (2008) (0)
Epithelial migration in the mouse cornea: Effect of knockouts of genes in the plasminogen activator plasmin system (1996) (0)
439: Intra-amniotic VEGF administration in fetal rats with nitrofen induced lung hypoplasia – A placebo controlled study (2008) (0)
Neuropilin-1 (Nrp-1) as a prognostic biomarker and potential drug target for pediatric medulloblastoma. (2013) (0)
Hypoxia-inducible factors activation protects mitochondria function and prevents albuminuria in kidney-specific diabetic von Hippel-Lindau deficient mice (2019) (0)
The role of the PHDs in vascular development (2010) (0)
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines (2020) (0)
Urokinase plasminogen activator promotes keratinocyte proliferation in vivo (1998) (0)
485 Inhibition of urokinase and matrix metalloproteinases prevents left ventricular hypertrophy and cardiac failure during hypertension (2004) (0)
Cell Metabolism Hypothalamic Barriers in CNS Control of Feeding (2013) (0)
Inhibition of PLGF in the treatment of Philadelphia chromosome positive leukemia (2009) (0)
Reduced dissemination of Lewis lung carcinoma in mice genetically deficient for urokinase-type (u-PA) plasminogen activator (1997) (0)
The importance of enzyme cofactors: tissue factor in blood coagulation and beyond (2003) (0)
Oxygen sensors, metabolism and neuroprotection: unexpected liaisons with therapeutic opportunities for neurodegeneration? (2013) (0)
NOTCHing the angiogenic vasculature in cancer. CNIO seminars; 12th of February 2015; CNIO, Madrid, Spain (2015) (0)
Stabilin‐1 protects against adverse inflammation and injury during viral myocarditis (2012) (0)
A PLACEBO CONTROLLED STUDY ON LUNG MECHANICS AFTER INTRA-AMNIOTIC INJECTION OF VEGF IN PRETERM RABBITS (2008) (0)
The Anti-plgf Antibody (5d11d4) Specifically Reduces Choroidal Neovascularization in vivo on a Mouse Model (2010) (0)
The role of hypoxia-induced macroautophagy in melanomagenesis (2010) (0)
Macrophage-derived glutamine boosts satellite cells and muscle regeneration (2020) (0)
Role of Growth Arrest-Specific Gene 6 Product (Gas6) in Severe Sepsis. (2006) (0)
Evaluation of the Role of PlGF and the Therapeutic Potential of Anti-PlGF in BCR/ABL+ Leukemia. (2008) (0)
BELGIAN ASSOCIATION FOR THE STUDY OF CANCER (2006) (0)
Pleiotropic phenotypes in PTPA (PP2A Activator)-deficient mice (2011) (0)
The Glycolysis Regulatory Enzyme PFK‐FB3 Enhances Endothelial Barrier Restoration in Acute Lung Injury (2017) (0)
Role of the urokinase receptor uPAR and plasmin in the maintenance, engraftment and mobilization of hematopoietic progenitor cells (2007) (0)
Deficiency of myeloid prolyl hydroxylase domain proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling (2021) (0)
142 Lack of aneurysm formation in atherosclerotic aorta from plasminogen activator deficient mice due to reduced metalloproteinase activity (1997) (0)
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma (2016) (0)
ROLE OF THE FIBRINOLYTIC AND THE COAGULATION SYSTEM IN THE FORMATION AND DISORDERS OF BLOOD VESSELS (1998) (0)
Abstract IA23: Angiogenesis revisited: Principles and strategies (2015) (0)
Mimecan promotes wound healing after myocardial infarction (2012) (0)
An unexpected role for NuSAP in the developing growth plate (2007) (0)
Increased Expression of Syndecan-1 Protects Against Cardiac Dilatation and Dysfunction After Myocardial Infarction Heart Failure (2007) (0)
The role of angiogenic growth factors in intimal hyperplasia (2005) (0)

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