Peter Dervan
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American chemist
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Chemistry
Peter Dervan's Degrees
- Bachelors Chemistry Haverford College
Why Is Peter Dervan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Peter B. Dervan is the Bren Professor of Chemistry at the California Institute of Technology. The primary focus of his research is the development and study of small organic molecules that can sequence-specifically recognize DNA, a field in which he is an internationally recognized authority. The most important of these small molecules are pyrrole–imidazole polyamides. Dervan is credited with influencing "the course of research in organic chemistry through his studies at the interface of chemistry and biology" as a result of his work on "the chemical principles involved in sequence-specific recognition of double helical DNA". He is the recipient of many awards, including the National Medal of Science .
Peter Dervan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes (1993) (7826)
- Sequence-specific cleavage of double helical DNA by triple helix formation. (1987) (977)
- Molecular recognition of DNA by small molecules. (2001) (757)
- Design of sequence-specific DNA-binding molecules. (1986) (689)
- Recognition of the DNA minor groove by pyrrole-imidazole polyamides. (2003) (552)
- Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands (1998) (423)
- Regulation of gene expression by small molecules (1997) (398)
- Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation. (1991) (396)
- Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II) (1982) (366)
- Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses. (1984) (357)
- Recognition of DNA by designed ligands at subnanomolar concentrations (1996) (326)
- Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation. (1989) (313)
- Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids (1996) (281)
- A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. (1998) (257)
- Sequence-specific DNA recognition by polyamides. (1999) (234)
- Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II). (1982) (232)
- Triple helix formation by oligonucleotides on DNA extended to the physiological pH range (1989) (210)
- Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. (2004) (203)
- Defining the sequence-recognition profile of DNA-binding molecules. (2006) (194)
- Molecular recognition of B-DNA by Hoechst 33258 (1985) (185)
- Structural basis for G•C recognition in the DNA minor groove (1998) (183)
- Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide (2007) (183)
- Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with (methidiumpropyl-EDTA)iron(II). (1983) (181)
- Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study. (1990) (180)
- Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. (1998) (174)
- Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif (1992) (169)
- Echinomycin binding sites on DNA. (1984) (167)
- Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). (1985) (165)
- Site-specific cleavage of a yeast chromosome by oligonucleotide-directed triple-helix formation. (1990) (162)
- Recognition of thymine adenine.base pairs by guanine in a pyrimidine triple helix motif. (1989) (159)
- Design of a G.C-specific DNA minor groove-binding peptide. (1994) (155)
- Hairpin Peptide Motif. A New Class of Oligopeptides for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA (1994) (152)
- Activation of gene expression by small molecule transcription factors. (2000) (152)
- Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. (2003) (150)
- Targeting the minor groove of DNA. (1997) (145)
- Site-specific cleavage of human chromosome 4 mediated by triple-helix formation. (1991) (139)
- Allosteric modulation of DNA by small molecules (2009) (139)
- DNA affinity cleaving : Sequence specific cleavage of DNA by Distamycin-EDTA - Fe(II) and EDTA-distamycin Fe(II) (1984) (135)
- Recognition of mixed-sequence duplex DNA by alternate-strand triple-helix formation (1990) (135)
- Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture (2003) (134)
- On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. (1997) (132)
- Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA. (1990) (132)
- Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. (1992) (129)
- Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids. (2001) (129)
- Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders (2011) (126)
- DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. (2006) (125)
- Aliphatic/aromatic amino acid pairings for polyamide recognition in the minor groove of DNA (1998) (124)
- Programmable DNA binding oligomers for control of transcription. (2005) (123)
- Models for photochemical electron transfer at fixed distances. Porphyrin-bicyclo[2.2.2]octane-quinone and porphyrin-bisbicyclo[2.2.2]octane-quinone (1984) (122)
- Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system. (1992) (117)
- Effect of exothermicity on electron transfer rates in photosynthetic molecular models (1987) (117)
- Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. (2002) (116)
- Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. (2007) (115)
- Methidiumpropyl-EDTA.Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA. (1983) (113)
- Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites. (1992) (113)
- Antitumor activity of a pyrrole-imidazole polyamide (2013) (113)
- Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation. (1993) (111)
- Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression (2009) (106)
- Design synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron(II) (1982) (106)
- Site-specific enzymic incorporation of an unnatural base, N^6-(6-aminohexyl)isoguanosine, into RNA (1993) (106)
- Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation (1991) (105)
- Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells* (2012) (102)
- Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. (2001) (100)
- Recognition of all four base pairs of double-helical DNA by triple-helix formation: design of nonnatural deoxyribonucleosides for pyrimidine•purine base pair binding (1992) (96)
- Synthesis of a sequence-specific DNA-cleaving peptide. (1987) (95)
- Design of a nonnatural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation (1992) (95)
- Sequence specific fluorescence detection of double strand DNA. (2003) (93)
- Structural basis for the initiation of eukaryotic transcription-coupled DNA repair (2017) (93)
- Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. (2004) (92)
- Design of artificial transcriptional activators with rigid poly-L-proline linkers. (2002) (91)
- Picosecond fluorescence studies on intramolecular photochemical electron transfer in porphyrins linked to quinones at two different fixed distances (1985) (90)
- Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes. (2001) (89)
- Improved nuclear localization of DNA-binding polyamides (2006) (87)
- Double strand cleavage of genomic DNA at a single site by triple helix formation (1988) (86)
- Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding (2010) (82)
- Molecular recognition of the nucleosomal "supergroove". (2004) (80)
- Nickel-mediated sequence-specific oxidative cleavage of DNA by a designed metalloprotein (1990) (80)
- Enhanced Sequence Specific Recognition in the Minor Groove of DNA by Covalent Peptide Dimers: Bis(pyridine-2-carboxamidonetropsin)(CH2)3–6 (1993) (80)
- RECOGNITION OF 16 BASE PAIRS IN THE MINOR GROOVE OF DNA BY A PYRROLE-IMIDAZOLE POLYAMIDE DIMER (1998) (79)
- NMR Characterization of Hairpin Polyamide Complexes with the Minor Groove of DNA (1997) (78)
- Sequence-specific alkylation of double-helical DNA by oligonucleotide-directed triple-helix formation (1990) (77)
- Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination. (1996) (77)
- Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving. (1990) (75)
- Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates. (2000) (74)
- Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. (2005) (74)
- Arresting cancer proliferation by small-molecule gene regulation. (2004) (74)
- Blocking transcription through a nucleosome with synthetic DNA ligands. (2002) (74)
- Design and chemical synthesis of a sequence-specific DNA-cleaving protein (1988) (73)
- Small molecule transcription factor mimic. (2004) (73)
- Chemical approaches to control gene expression. (2000) (73)
- Flanking sequence effects within the pyrimidine triple-helix motif characterized by affinity cleaving. (1992) (70)
- Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s. (1985) (70)
- Extension of sequence-specific recognition in the minor groove of DNA by pyrrole-imidazole polyamides to 9-13 base pairs (1996) (70)
- Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by a distamycin/1-methylimidazole-2-carboxamide-netropsin pair (1993) (68)
- OPTIMIZATION OF THE HAIRPIN POLYAMIDE DESIGN FOR RECOGNITION OF THE MINOR GROOVE OF DNA (1996) (68)
- Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp (1995) (68)
- Towards a minimal motif for artificial transcriptional activators. (2001) (68)
- Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-κB, and DNA by a Designed DNA-binding Ligand* (1999) (68)
- Recognition of double helical DNA by alternate strand triple helix formation (1992) (67)
- Quantitative microarray profiling of DNA-binding molecules. (2007) (66)
- Programming multiple protein patterns on a single DNA nanostructure. (2008) (66)
- Cleavage of chromatin with methidiumpropyl-EDTA . iron(II). (1983) (66)
- Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing (2012) (65)
- Solid-phase synthesis of DNA binding polyamides on oxime resin. (2002) (65)
- Toward an Understanding of the Chemical Etiology for DNA Minor‐Groove Recognition by Polyamides (2002) (65)
- Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition (2014) (65)
- The influence of single base triplet changes on the stability of a pur.pur.pyr triple helix determined by affinity cleaving. (1992) (64)
- Sequence-specific oxidative cleavage of DNA by a designed metalloprotein, Ni(II).GGH(Hin139-190). (1992) (64)
- Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides (2002) (64)
- DISCRIMINATION OF 5'-GGGG-3', 5'-GCGC-3', AND 5'-GGCC-3' SEQUENCES IN THE MINOR GROOVE OF DNA BY EIGHT-RING HAIRPIN POLYAMIDES (1997) (63)
- Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. (2009) (63)
- DNA-templated dimerization of hairpin polyamides. (2003) (63)
- Energetics of Formation of Sixteen Triple Helical Complexes Which Vary at a Single Position Within a Purine Motif (1995) (62)
- Reagents for the site-specific cleavage of megabase DNA (1992) (62)
- Effects of the A.T/T.A degeneracy of pyrrole--imidazole polyamide recognition in the minor groove of DNA. (1996) (62)
- Addressing single molecules on DNA nanostructures. (2007) (61)
- Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. (2003) (61)
- Trimethylsilylpotassium. Deoxygenation of epoxides with inversion of stereochemistry (1976) (60)
- Completion of a Programmable DNA-Binding Small Molecule Library. (2007) (60)
- Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. (2004) (60)
- Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA. (1993) (59)
- Cycle Polyamide Motif for Recognition of the Minor Groove of DNA (1999) (58)
- Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA (1987) (58)
- Adenine-specific DNA chemical sequencing reaction. (1987) (58)
- Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase. (1990) (58)
- Targeting the Ets Binding Site of the HER2/neuPromoter with Pyrrole-Imidazole Polyamides* (2000) (58)
- Accessibility of nuclear chromatin by DNA binding polyamides. (2003) (57)
- Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. (2008) (56)
- Orientation Preferences of Pyrrole−Imidazole Polyamides in the Minor Groove of DNA (1997) (56)
- Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif. (1996) (55)
- Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule (1978) (54)
- Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: linkage to cation valence and concentration. (1993) (53)
- Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. (2003) (53)
- Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. (2000) (53)
- Toward rules for 1:1 polyamide:DNA recognition (2001) (53)
- Specific recognition of CG base pairs by 2-deoxynebularine within the purine.purine.pyrimidine triple-helix motif. (1993) (53)
- DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. (2003) (52)
- Structural Basis for Eukaryotic Transcription-Coupled DNA Repair Initiation (2017) (52)
- Sequence-specific cleavage of DNA by N-bromoacetyldistamycin. Product and kinetic analyses (1989) (51)
- RecA.oligonucleotide filaments bind in the minor groove of double-stranded DNA. (1995) (51)
- The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA. (1999) (51)
- Single-strand DNA triple-helix formation. (1990) (51)
- Nucleosomes in solution exist as a mixture of twist-defect states. (2005) (51)
- Effects of γ-Turn and β-Tail Amino Acids on Sequence-Specific Recognition of DNA by Hairpin Polyamides (1999) (50)
- Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving. (1984) (50)
- Nonenzymatic ligation of oligodeoxyribonucleotides on a duplex DNA template by triple-helix formation (1989) (49)
- Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrolecarboxamide with pyridine-2-carboxamide (1987) (49)
- Sequence-specific double-strand alkylation and cleavage of DNA mediated by triple-helix formation (1992) (49)
- Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element (2013) (49)
- Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. (1999) (49)
- Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells. (2016) (48)
- Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II). (1983) (48)
- Thermodynamics of oligodeoxyribonucleotide-directed triple helix formation: an analysis using quantitative affinity cleavage titration (1992) (47)
- Cyclic polyamides for recognition in the minor groove of DNA. (1995) (47)
- Design of a sequence-specific DNA bisintercalator. (2004) (47)
- Programmable oligomers for minor groove DNA recognition. (2006) (47)
- Sequence specific recognition of b dna by bis edta distamycin fumaramide (1985) (47)
- Recognition in the Minor Groove of DNA at 5'-(A,T)GCGC(A,T)-3' by a Four Ring Tripeptide Dimer. Reversal of the Specificity of the Natural Product Distamycin (1995) (47)
- Recognition of seven base pair sequences in the minor groove of DNA by ten-ring pyrrole-imidazole polyamide hairpins (1997) (47)
- Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin•Fe^(II)) and EDTA-bis(distamycin)•Fe^(II) (1983) (45)
- Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA. (1994) (45)
- Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. (2008) (45)
- Formation and thermal rearrangements of some dimers of butadiene and piperylene. Tests of the validity of thermochemical-kinetic arguments for identification of common biradical intermediates (1976) (45)
- Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus (2013) (45)
- A synthetic peptide binds 16 base pairs of A,T double helical DNA (1987) (45)
- The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro. (1999) (45)
- Phosphorothioate oligonucleotide-directed triple helix formation. (1994) (44)
- Design of a Covalent Peptide Heterodimer for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA (1994) (44)
- Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA. (1996) (43)
- Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole–Imidazole Polyamides (1999) (43)
- A Pyrrole‐Imidazole Polyamide Motif for Recognition of Eleven Base Pair Sequences in the Minor Groove of DNA (1997) (43)
- Comparison of Synthetic Psoralen Derivatives and 8‐MOP in the Inhibition of Lymphocyte Proliferation a (1985) (42)
- Expanding the recognition of the minor groove of DNA by incorporation of beta-alanine in hairpin polyamides. (2001) (41)
- Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. (2005) (41)
- Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. (2001) (41)
- Visualization of RNA tertiary structure by RNA-EDTA.Fe(II) autocleavage: analysis of tRNA(Phe) with uridine-EDTA.Fe(II) at position 47. (1994) (41)
- Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch. (1998) (41)
- Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA. (1987) (41)
- Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide (2012) (41)
- Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. (2009) (40)
- A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer. (2017) (40)
- Molecular recognition of nucleic acid by small molecules. Binding affinity and structural specificity of bis(methidium)spermine (1979) (40)
- Recognition of a 5'-(A,T)GGG(A,T)2-3' Sequence in the Minor Groove of DNA by an Eight-Ring Hairpin Polyamide (1996) (40)
- Sequence‐Specific Recognition of DNA by a Major and Minor Groove Binding Ligand (1996) (40)
- Strand Selective Cleavage of DNA by Diastereomers of Hairpin Polyamide-seco-CBI Conjugates (2000) (39)
- In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography (2008) (38)
- Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns (2012) (38)
- Structural analysis of covalent peptide dimers, bis(pyridine-2-carboxamidonetropsin)(CH_2)_(3-6), in complex with 5'-TGACT-3' sites by two-dimensional NMR (1993) (38)
- Synthesis and thermal decomposition of cis-3,4,5,6-tetrahydropyridazine-3,4-d2. Relative rates of rotation, cleavage, and closure for tetramethylene (1980) (38)
- The Nonnatural Deoxyribonucleoside D3 Incorporated in an Intramolecular DNA Triplex Binds Sequence Specifically by Intercalation (1993) (37)
- Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates (2012) (36)
- Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition. (2004) (36)
- Fluorescent sequence-specific dsDNA binding oligomers. (2007) (36)
- Recognition of 5'-(A,T)GG(A,T)2-3' Sequences in the Minor Groove of DNA by Hairpin Polyamides (1996) (35)
- Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia (2008) (35)
- Stereochemical Control of the DNA Binding Affinity , Sequence Specificity , and Orientation Preference of Chiral Hairpin Polyamides in the Minor Groove (1998) (35)
- Toward artificial developmental regulators. (2003) (34)
- Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. (2013) (34)
- Kinetic consequences of covalent linkage of DNA binding polyamides. (2001) (34)
- Inhibition of DNA Binding by NF-κB with Pyrrole-Imidazole Polyamides (2002) (34)
- Recognition of the Minor Groove of DNA by Hairpin Polyamides Containing α-Substituted-β-Amino Acids (2000) (34)
- Synthesis of Cyclic Py-Im Polyamide Libraries (2012) (34)
- Recognition of ten base pairs of DNA by head-to-head hairpin dimers. (2002) (33)
- Structure of a stereoregular phosphorothioate DNA/RNA duplex (1998) (33)
- Triple-Helix Formation by Pyrimidine Oligonucleotides Containing Nonnatural Nucleosides with Extended Aromatic Nucleobases: Intercalation from the major groove as a method for recognizing C·G and T·A base pairs (1997) (33)
- Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. (2008) (33)
- Characterization of protein-DNA complexes by affinity cleaving. (1991) (33)
- Synthesis and direct spectroscopic observation of a 1,1-dialkyldiazene. Infrared and electronic spectrum of N-(2,2,6,6-tetramethylpiperidyl)nitrene (1978) (33)
- Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. (2011) (33)
- Direct studies of 1,1-diazenes. Syntheses, infrared and electronic spectra, and kinetics of the thermal decomposition of N-(2,2,6,6-tetramethylpiperidyl)nitrene and N-(2,2,5,5-tetramethylpyrrolidyl)nitrene (1982) (33)
- Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides (2002) (32)
- Microwave Assisted Synthesis of Py-Im Polyamides (2012) (32)
- NMR structure of a cyclic polyamide-DNA complex. (2004) (32)
- Low-temperature matrix isolation of the 1,1-diazene H2NN. Electronic and infrared characterization (1984) (32)
- Design of an N7-Glycosylated Purine Nucleoside for Recognition of GC Base Pairs by Triple Helix Formation (1995) (32)
- Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common site on DNA. (1992) (31)
- Footprinting with MPE.Fe(II). Complementary-strand analyses of distamycin- and actinomycin-binding sites on heterogeneous DNA. (1983) (30)
- Controlling binding orientation in hairpin polyamide DNA complexes (2000) (30)
- Search for the optimal linker in tandem hairpin polyamides. (2002) (30)
- Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. (2012) (30)
- Regulation of gene expression by synthetic DNA-binding ligands (2005) (30)
- Cooperative site specific binding of oligonucleotides to duplex DNA (1989) (29)
- Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice (2012) (29)
- Weak temperature dependence of electron transfer rates in fixed-distance porphyrin-quinone model systems (1994) (29)
- Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. (2003) (29)
- Cooperative binding of oligonucleotides to DNA by triple helix formation: dimerization via Watson-Crick hydrogen bonds (1991) (29)
- Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation. (1994) (28)
- Solution-phase synthesis of pyrrole-imidazole polyamides. (2009) (28)
- Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. (1990) (28)
- Sequence Selectivity of 3-Hydroxypyrrole/Pyrrole Ring Pairings in the DNA Minor Groove (1999) (27)
- Nitrogen-15 NMR spectrum of a 1,1-diazene. N-(2,2,6,6-tetramethylpiperidyl)nitrene (1981) (27)
- Nonenzymic sequence-specific ligation of double-helical DNA (1991) (27)
- Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. (2004) (27)
- Triple helix-mediated single-site enzymatic cleavage of megabase genomic DNA. (1992) (27)
- Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole. (2000) (26)
- Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex. (1997) (26)
- Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit (2013) (26)
- Extending the recognition site of designed minor groove binding molecules (1996) (26)
- Specific sequence-specific recognition of right-handed double-helical DNA by (2S,3S)- and (2R,3R)-dihydroxybis(netropsin)succinamide (1986) (26)
- Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation. (1996) (25)
- Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response (2014) (25)
- Nonenzymatic sequence-specific cleavage of single-stranded DNA to nucleotide resolution. DNA methyl thioether probes (1987) (25)
- Mapping RNA regions in eukaryotic ribosomes that are accessible to methidiumpropyl-EDTA.Fe(II) and EDTA.Fe(II). (1994) (25)
- Rearrangement of trans-1,2-divinylcyclobutane and the energy surface of the dimers of butadiene (1973) (25)
- Affinity and specificity of multiple hydroxypyrrole/pyrrole ring pairings for coded recognition of DNA (1999) (25)
- Solution structure of an intramolecular DNA triplex containing an N7-glycosylated guanine which mimics a protonated cytosine. (1997) (25)
- Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. (2003) (25)
- Trimethylsilyl anions. Direct synthesis of trimethylsilylbenzenes (1977) (25)
- Sequence Specific Cleavage of Double Helical DNA N-Bromoacetyldistamycin (1985) (24)
- Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. (2002) (24)
- Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. (2006) (24)
- Cell-free and Cellular Activities of a DNA Sequence Selective Hairpin Polyamide-CBI Conjugate* (2002) (24)
- Preparation of thioesters for the ligation of peptides with non-native substrates☆ (2000) (23)
- Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates (2006) (23)
- Recognition of "mirror-image" DNA by small molecules. (2007) (23)
- RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif (2016) (23)
- Effects of an abasic site on triple helix formation characterized by affinity cleaving. (1991) (23)
- Sequence composition effects on the stabilities of triple helix formation by oligonucleotides containing N7-deoxyguanosine. (1996) (23)
- A Two-Hit Mechanism for Pre-Mitotic Arrest of Cancer Cell Proliferation by a Polyamide-Alkylator Conjugate (2006) (23)
- Cooperative Hairpin Dimers for Recognition of DNA by Pyrrole-Imidazole Polyamides. (1998) (22)
- Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide (2015) (22)
- Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand. (1999) (22)
- Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray. (2009) (22)
- Photochemistry of 1,1-diazenes. Direct and sensitized photolyses of N-(2,2,5,5-tetramethylpyrrolidyl)nitrene, dl-N-(2,5-diethyl-2,5-dimethylpyrrolidyl)nitrene, and N-(2,2,6,6-tetramethylpiperidyl)nitrene (1982) (22)
- Design of artificial sequence-specific DNA bending ligands. (1996) (22)
- Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3. (1996) (22)
- Asymmetric DNA binding by a homodimeric bHLH protein. (2000) (21)
- Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. (2012) (21)
- Incremental substituent effects leading to steric blockade of the boat-like six-center Cope rearrangement of cis-1,2-dialkenylcyclobutanes (1972) (21)
- Sequence Composition Effects on the Energetics of Triple Helix Formation by Oligonucleotides Containing a Designed Mimic of Protonated Cytosine (1995) (20)
- Minimization of a protein-DNA dimerizer. (2007) (20)
- Tumor Xenograft Uptake of a Pyrrole–Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted (2014) (20)
- Temperature Dependence of the Energetics of Oligonucleotide-Directed Triple-Helix Formation at a Single DNA Site (1994) (20)
- Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA (2011) (20)
- Cooperative Binding of 8-mer Oligonucleotides Containing 5-(1-Propynyl)-2'-deoxyuridine to Adjacent DNA Sites by Triple-Helix Formation (1994) (20)
- Mechanism of sequence-specific fluorescent detection of DNA by N-methyl-imidazole, N-methyl-pyrrole, and β-alanine linked polyamides (2004) (20)
- A Comparison of H‐Pin and Hairpin Polyamide Motifs for the Recognition of the Minor Groove of DNA (1998) (19)
- Nonenymatic ligation of double-helical DNA by alternate-strand triple helix formation. (1992) (19)
- Experimental determination of the relative rates of rotation, cleavage, closure, and 1,5-hydrogen shift for 3-methyl-1,4-pentanediyl. Evidence for 1,4 biradicals as common intermediates from different precursors, 3,4-(and 3,6-)dimethyl-3,4,5,6-tetrahydropyridazines and 1,2-dimethylcyclobutanes (1979) (19)
- Mechanistic analysis of the four pathways in the 1,3-sigmatropic rearrangements of trans-1,2-trans, trans- and trans-1,2-cis,trans-dipropenylcyclobutane (1973) (19)
- Synthesis and direct spectroscopic observation of N-(2,2,5,5-tetramethylpyrrolidinyl)nitrene. Comparison of five- and six-membered cyclic 1,1-dialkyldiazenes (1980) (19)
- NMR Characterization of the Aliphatic β/β Pairing for Recognition of A·T/T·A Base Pairs in the Minor Groove of DNA (1999) (19)
- Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides. (2001) (19)
- Influence of β‐Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove (2003) (18)
- Reagents and methods for the solid-phase synthesis of protein-EDTA for use in affinity cleaving (1990) (18)
- Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. (2007) (17)
- Hydroxybenzamide/pyrrole pair distinguishes T·A from A·T base pairs in the minor groove of DNA (2000) (17)
- Adenine specific DNA chemical sequencing reaction. (1987) (17)
- DNA sequence selectivity of hairpin polyamide turn units. (2009) (17)
- Cooperative triple-helix formation via a minor groove dimerization domain (1996) (17)
- U-pin polyamide motif for recognition of the DNA minor groove. (2003) (17)
- Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif. (2000) (16)
- Cooperative oligonucleotide-directed triple helix formation at adjacent DNA sites (1993) (16)
- Kinetics of the thermal decomposition of a 1,1-dialkyldiazene, N-(2,2,6,6-tetramethylpiperidyl)nitrene (1979) (16)
- Temperature-sensitive protein-DNA dimerizers. (2005) (16)
- Molecular Recognition of DNA by Hoechst Benzimidazoles: Exploring Beyond the Pyrrole-Imidazole-Hydroxypyrrole Polyamide-Pairing Code (2000) (16)
- NMR structural studies on a nonnatural deoxyribonucleoside which mediates recognition of GC base pairs in pyrimidine-purine-pyrimidine DNA triplexes. (1993) (16)
- Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences. (2003) (16)
- Oligonucleotide-directed DNA triple-helix formation: an approach to artificial repressors? (1991) (15)
- Different conformational families of pyrimidine.purine.pyrimidine triple helices depending on backbone composition. (1994) (15)
- Thermal decomposition of cis- and trans-3,4- and -3,6-dimethyl-3,4,5,6-tetrahydropyridazines. Evidence against the hot diradical postulate for azo decompositions (1976) (15)
- Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase. (2003) (14)
- α-Diaminobutyric Acid-Linked Hairpin Polyamides (2007) (14)
- Photochemistry of a 1,1-diazene, N-(2,2,5,5-tetramethylpyrrolidinyl)nitrene (1981) (14)
- Stereochemical tests of cyclic 1,1-dialkyldiazene fragmentation reactions. Thermal decomposition of N-(cis-(and trans-)2,3-(and 2,5-)dimethylpyrrolidine)nitrenes (1979) (13)
- An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors (2015) (13)
- Stereospecific double rearrangement of trans-3,4-dimethyl-cis,trans-cycloocta-1,5-diene to cis-3,4-dimethyl-cis,cis-cycloocta-1,5-diene (1972) (13)
- Ligand-Promoted Dimerization of Oligonucleotides Binding Cooperatively to DNA (1992) (13)
- Energetics of cooperative binding of oligonucleotides with discrete dimerization domains to DNA by triple helix formation. (1993) (13)
- A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor. (2014) (13)
- A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity (2016) (13)
- Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide (2019) (12)
- Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation. (1997) (12)
- Design of a Nonnatural Deoxyribonucleoside for Recognition of GC Base Pairs by Oligonucleotide‐Directed Triple Helix Formation. (1992) (12)
- DNA Damage Effects of a Polyamide-CBI Conjugate in SV40 Virions (2005) (12)
- A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma (2015) (12)
- Alternative heterocycles for DNA recognition: a 3-pyrazole/pyrrole pair specifies for G.C base pairs. (2000) (12)
- Sequence specificity of the non-natural pyrido[2, 3-d]pyrimidine nucleoside in triple helix formation (1994) (12)
- Structural motif of the DNA binding domain of gamma delta-resolvase characterized by affinity cleaving. (1990) (11)
- Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid (1982) (11)
- Cooperative Triple-Helix Formation at Adjacent DNA Sites: Sequence Composition Dependence at the Junction (1995) (11)
- Thermal decomposition of cis-tetrahydropyridazine-3,4-d2. Relative rates of rotation, cleavage, and closure for tetramethylene (1979) (11)
- Syntheses and Decomposition of meso- and dl-2,3-Dimethylsuccinyl and cis- and trans-1,2-Hexahydrophthaloyl Peroxides (1979) (11)
- Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation (1989) (11)
- Sequence Specific Recognition of Double Helical DNA. A Synthetic Approach (1988) (10)
- Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. (2002) (10)
- Selective inhibition of DNA gyrase in vitro by a GC specific eight‐ring hairpin polyamide at nanomolar concentration (2000) (10)
- Nonenzymatic sequence-specific methyl transfer to single-stranded DNA. (1988) (9)
- 1,1-Di-tert-butyldiazene (1982) (9)
- Oligomerization route to Py-Im polyamide macrocycles. (2009) (8)
- Stereodistal Cope rearrangement of trans-1,2-dialkenylcyclobutanes (1972) (8)
- Interactions between a symmetrical minor groove binding compound and DNA oligonucleotides: 1H and 19F NMR studies. (1989) (8)
- Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving. (1991) (8)
- Alternative heterocycles for DNA recognition: an N-methylpyrazole/N-methylpyrrole pair specifies for A.T/T.A base pairs. (2001) (8)
- Analysis of hairpin polyamide complexes having DNA binding sites in close proximity. (2002) (8)
- Sequence-selective inhibition of restriction endonucleases by the polyintercalator bis(methidium)spermine (1982) (8)
- The reach of linear protein-DNA dimerizers. (2007) (8)
- Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous DNA. Footprinting with methidiumpropyl-EDTA•iron(II) (1983) (7)
- Synthesis of a hybrid protein containing the iron-binding ligand of bleomycin and the DNA-binding domain of Hin. (1994) (7)
- Molecular Recognition of DNA by Py–Im Polyamides: From Discovery to Oncology (2018) (7)
- DNA Minor‐Groove Recognition by 3‐Methylthiophene/Pyrrole Pair (2004) (7)
- Specific activation of open complex formation at an Escherichia coli promoter by oligo(N-methylpyrrolecarboxamide)s: effects of peptide length and identification of DNA target sites. (1989) (6)
- The Origins of the DNA Binding Affinity and Specificity of Minor Groove Directed Ligands: Correlations of Thermodynamic and Structural Data (1990) (6)
- Alpha-diaminobutyric acid-linked hairpin polyamides. (2007) (5)
- Paradoxical effects of DNA binding polyamides on HTLV-1 transcription. (2004) (5)
- The Importance of β‐Alanine for Recognition of the Minor Groove of DNA (2007) (5)
- Design of a Sequence-Specific DNA (2004) (5)
- Simultaneous binding of a polyamide dimer and an oligonucleotide in the minor and major grooves of DNA. (1996) (4)
- Design of Sequence‐specific DNA Cleaving Molecules (1986) (4)
- Sequence-Specific Chiral Recognition of Right-Handed Double-Helical DNA by (2S,3S)- (Ia) and (2R,3R)-Dihydroxybis(netropsin)succinamide (Ib). (1986) (4)
- A stereochemical test of similarly substituted tetramethylenediazene and cyclic azo decompositions in the gas phase at the same temperature (1976) (4)
- Design and Chemical Synthesis of a Sequence-Specific DNA-Cleaving Protein. (1989) (3)
- Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin.iron(II)) and EDTA-bis(distamycin).iron(II) (1983) (3)
- Design of sequence specific DNA binding molecules: bis(distamycin)phenoxazone (1986) (3)
- Crystallization and preliminary X-ray analysis of the DNA binding domain of the Hin recombinase with its DNA binding site. (1993) (3)
- Sequence Specific Fluorescence Detection of Double Strand DNA [J. Am. Chem. Soc. 2003, 125, 1195−1202]. (2003) (3)
- Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide (2018) (3)
- Six-membered cyclic diacyl peroxide fragmentations. Thermal decomposition of meso- and dl-2,3-dimethylsuccinoyl peroxides (1977) (3)
- Thermal decomposition of cis-tetrahydropyridazine-3,4-d_2. Relative rates of rotation, cleavage, and closure for tetramethylene (1979) (2)
- Sequence specific recognition and cleavage of double helical DNA (1988) (2)
- A Personal Perspective on Chemical Biology: Before the Beginning (2019) (2)
- MODELS FOR PHOTOCHEMICAL ELECTRON TRANSFER AT FIXED DISTANCES. PORPHYRIN-BICYCLO(2.2.2)OCTANE-QUINONE AND PORPHYRIN-BISBICYCLO(2.2.2)OCTANE-QUINONE (1985) (2)
- Alteration of the Sequence Specificity of Distamycin on DNA by Replacement of an N-Methylpyrrolecarboxamide with Pyridine-2-carboxamide. (1987) (2)
- A Synthetic Peptide Binds 16 Base Pairs of A,T Double Helical DNA. (1988) (2)
- LOW‐TEMPERATURE MATRIX ISOLATION OF THE 1,1‐DIAZENE H2NN. ELECTRONIC AND INFRARED CHARACTERIZATION (1984) (2)
- Evidence for a stereospecific 1,2-elimination reaction in a 1,1-diazene. Synthesis and decomposition of [N-phenyl(threo- and erythro)-2-deuterio-1-methylpropyl)amino]nitrene (1983) (2)
- Arresting Cancer Proliferation by Small-Molecule Gene Regulation (DOI:10.1016/j.chembiol.2004.09.004) (2006) (2)
- RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder (2022) (2)
- Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides (2020) (2)
- Transition-metal mediated oxidative cleavage of DNA by designed metalloproteins (1990) (1)
- Design of synthetic sequence specific DNA binding molecules (1987) (1)
- 7-Azabicyclo[2.2.1]heptane N-Imide as an Intermediate in the Thermal Decomposition of N-Amino-7-Azabicyclo[2.2.1]heptane and the Corresponding Benzenesulphonamide (1976) (1)
- Py-Im Polyamides Distinguish Double Helical DNA and RNA * * (2013) (1)
- Molecular Recognition of DNA by Hoechst Benzimidazoles: Exploring Beyond the Pyrrole‐Imidazole‐Hydroxypyrrole Polyamide‐Pairing Code. (2000) (1)
- Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome (2020) (1)
- T.P.2 09 Overcoming the transcription defect in Friedreich ataxia with designed DNA ligands (2006) (1)
- Cover Picture: U-Pin Polyamide Motif for Recognition of the DNA Minor Groove (Chem. Eur. J. 14/2003) (2003) (1)
- Designing Molecular Machines to Read the Genetic Blueprint (1991) (0)
- Bipolymers: Proteins and Nucleic Acids. (1995) (0)
- Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates (2004) (0)
- Operation and performance of the ATLAS Tile Calorimeter in Run 1 ATLAS Collaboration (2018) (0)
- 16 Chapter 2 Programming Protein Patterns on DNA Nanostructures (2008) (0)
- Design of sequence specific DNA-cleaving metalloproteins (1989) (0)
- HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE (1998) (0)
- Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models (2013) (0)
- Recognition of All Four Base Pairs of Duplex DNA by Triple Helix Formation. Design of Pyrimidine Specific Bases (1991) (0)
- Analysis of Nearest Neighbor Interactions in the Pyrimidine Triple Helix Motif by Affinity Cleaving (1991) (0)
- Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA. (1988) (0)
- Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models. (2013) (0)
- Abstract 5132: Targeting hypoxia-mediated gene transcription with a novel polyamide drug designed to disrupt the HIF1α/β heterodimer binding overcomes resistance to hypoxia in myeloma cell lines (2014) (0)
- ^(15)N NMR Spectrum of a 1,1-Diazene. N-(2,2,6,6-Tetramethylpiperidyl)nitrene (1981) (0)
- Chapter 3 Sequence Specific Detection of DNA Using Self-Quenched Fluorophore-Polyamide Conjugates (2003) (0)
- Next-Generation Programmable Oligomers for DNA Minor Groove Recognition (2005) (0)
- Synthetic Tools for Molecular Biology (1988) (0)
- Molecular recognition of DNA by small molecules: Fundamentals to applications (2014) (0)
- Characterization of myc amplicon size and orientation by triple helix mediated single site enzymatic cleavage (1993) (0)
- DNA Repair Interference with Sequence Specific DNA Binding Pyrrole Imidazole Polyamides; a Novel Radiation Sensitizer (2015) (0)
- Ronald Breslow Award for Achievement in Biomimetic Chemistry: David A. Tirrell (2019) (0)
- Spring 2007 Seminars (2007) (0)
- NMR Structure of a 1:1 Complex of Polyamide (Im-Py-Beta-Im-Beta-Im-Py-Beta-Dp) with the Tridecamer DNA Duplex 5'-CCAAAGAGAAGCG-3' (2002) (0)
- KINETICS OF THE THERMAL DECOMPOSITION OF A 1,1‐DIALKYLDIAZENE, N‐(2,2,6,6‐TETRAMETHYLPIPERIDYL)NITRENE (1980) (0)
- Radiosensitization by High Affinity Programmable Minor Groove Binders (2013) (0)
- J. D. Roberts Special Issue (2018) (0)
- CRYSTAL STRUCTURE OF POLYAMIDE DIMER (IMPYPYPYBETADP)2 BOUND TO CCAGATCTGG (2000) (0)
- HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE (1998) (0)
- A second-generation DNA-binding pyrrole-imidazole polyamide with antitumor activity. (2013) (0)
- Nonenzymatic Sequence-Specific Cleavage of Single-Stranded DNA to Nucleotide Resolution. DNA Methyl Thioether Probes. (1987) (0)
- UvA-DARE ( Digital Academic Repository ) The ATLAS simulation infrastructure (2018) (0)
- Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair (2018) (0)
- DNA DTA TRIPLEX, NMR, 7 STRUCTURES (1996) (0)
- Herbert C. Brown Award for Creative Research in Synthetic Methods: Gregory C. Fu (2018) (0)
- EVIDENCE FOR A STEREOSPECIFIC 1,2-ELIMINATION REACTION IN A 1,1-DIAZENE. SYNTHESIS AND DECOMPOSITION OF (N-PHENYL(THREO- AND ERYTHRO)-2-DEUTERIO-1-METHYLPROPYL)AMINO)NITRENE (1983) (0)
- Radiosensitization by DNA, Binding Pyrrole, Imidazole Polyamides (2015) (0)
- Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA * Fe ( II ) ( minor groove binding / netropsin / distamycin / restriction enzymes ) (1999) (0)
- Molecular recognition of DNA: From discovery to oncology (2018) (0)
- Gene expression changes in tumor xenografts by Py-Impolyamides (2013) (0)
- SEQUENCE-SPECIFIC RECOGNITION OF B DNA BY BIS(EDTA-DISTAMYCIN)FUMARAMIDE (1985) (0)
- Quantitating the Concentration of Polyamide-Fluorescein Conjugates in Live Cells (2008) (0)
- CHEMICAL REGULATION OF GENE EXPRESSION (2003) (0)
- Minor Groove Recognition of T , A Base Pairs by Benzothiophene / Pyrrole Pairs (2005) (0)
- Chemical methods for the site-specific cleavage of genomic DNA (1990) (0)
- NMR Structural Studies on a Nonnatural Deoxyribonucleoside Mediated Recognition of GC Base Pairs in Pyrimidine-Purine-Pyrimidine Triplexes (1993) (0)
- Sequence-Specific Cleavage of Double-Helical DNA. N-Bromoacetyldistamycin. (1986) (0)
- Inhibition of Vascular Endothelial Growth Factor with a Sequence-Specific HRE Antagonist (2007) (0)
- John D. Roberts (1988) (0)
- Structural basis for site-specific recognition of nucleosomal DNA (2002) (0)
- In ̄ uence of structural variation on nuclear localization of DNA-binding polyamide ̄ polyamide ̄ polyamide ̄ uorophore conjugates (2004) (0)
- SIX‐MEMBERED CYCLIC DIACYL PEROXIDE FRAGMENTATIONS. THERMAL DECOMPOSITION OF MESO‐ AND DL‐2,3‐DIMETHYLSUCCINOYL PEROXIDES (1977) (0)
- Regulation of gene expression by DNA binding Py-Im polyamides: Targeting transcription factor-DNA interfaces (2010) (0)
- Biopolymers: Proteins and Nucleic Acids. (1990) (0)
- EXPERIMENTAL DETERMINATION OF THE RELAT (1979) (0)
- Recognition of DNA by Hairpin Polyamides Containing N- Terminal Thiophene Residues (2005) (0)
- CRYSTAL STRUCTURE OF POLYAMIDE DIMER (IMPYHPPYBETADP)2 BOUND TO B-DNA DECAMER CCAGATCTGG (2000) (0)
- Biopolymers: protein and nucleic acids. Annual report, 15 September 1987-14 September 1988 (1988) (0)
- Title : Consequences of changes in mitochondrial metabolism in mouse models of altered frataxin expression (2007) (0)
- Ahmed H. Zewail (1946–2016) (2016) (0)
- Stalled DNA Replication Fo rks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich ’ s Ataxia Cells Graphical (2016) (0)
- LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA (2003) (0)
- Synthetic sequence specific DNA binding molecules (1987) (0)
- Towards the Regulation of Cyclin D1 using DNA binding Polyamides (2002) (0)
- TRIMETHYLSILYL ANIONS- DIRECT SYNTHESIS OF TRIMETHYLSILYLBENZENES (1977) (0)
- 7-AZABICYCLO(2.2.1)HEPTANE N-IMIDE AS AN INTERMEDIATE IN THE THERMAL DECOMPOSITION OF N-AMINO-7-AZABICYCLO(2.2.1)HEPTANE AND THE CORRESPONDING BENZENESULFONAMIDE (1976) (0)
- Molecular Recognition of DNA. Synthesis of Novel Bases for Triple Helix Formation (1991) (0)
- Sequence Specific Recognition of Double Helical DNA (1993) (0)
- A sequence-speci fi c DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma (2015) (0)
- Chapter 10 Targeting G-Tetrads in the DNA Minor Groove (2005) (0)
- Development of a novel polyamide-based agent to inhibit EVI1 function (2008) (0)
- Draft Readiness of the ATLAS Tile Calorimeter for LHC collisions Version : 3 . 0 To be submitted to : European Physics (2010) (0)
- AnHRE-BindingPy-ImPolyamide ImpairsHypoxic Signaling in Tumors (2016) (0)
- DNA Minor Groove Recognition by Multiple Thiophene / Pyrrole Pairs (2005) (0)
- Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides (2020) (0)
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